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Articles 2491 - 2520 of 27166
Full-Text Articles in Medicine and Health Sciences
Disordered Proteins Interact With The Chemical Environment To Tune Their Protective Function During Drying, Shraddha Kc, Kenny H Nguyen, Vincent Nicholson, Annie Walgren, Tony Trent, Edith Gollub, Paulette Sofia Romero-Perez, Alex S Holehouse, Shahar Sukenik, Thomas C Boothby
Disordered Proteins Interact With The Chemical Environment To Tune Their Protective Function During Drying, Shraddha Kc, Kenny H Nguyen, Vincent Nicholson, Annie Walgren, Tony Trent, Edith Gollub, Paulette Sofia Romero-Perez, Alex S Holehouse, Shahar Sukenik, Thomas C Boothby
2020-Current year OA Pubs
The conformational ensemble and function of intrinsically disordered proteins (IDPs) are sensitive to their solution environment. The inherent malleability of disordered proteins, combined with the exposure of their residues, accounts for this sensitivity. One context in which IDPs play important roles that are concomitant with massive changes to the intracellular environment is during desiccation (extreme drying). The ability of organisms to survive desiccation has long been linked to the accumulation of high levels of cosolutes such as trehalose or sucrose as well as the enrichment of IDPs, such as late embryogenesis abundant (LEA) proteins or cytoplasmic abundant heat-soluble (CAHS) proteins. …
Discovery Of Highly Potent And Alk2/Alk1 Selective Kinase Inhibitors Using Dna-Encoded Chemistry Technology, Ravikumar Jimmidi, Diana Monsivais, Hai Minh Ta, Kiran L Sharma, Kurt M Bohren, Srinivas Chamakuri, Zian Liao, Feng Li, John M Hakenjos, Jian-Yuan Li, Yuji Mishina, Haichun Pan, Xuan Qin, Matthew B Robers, Banumathi Sankaran, Zhi Tan, Suni Tang, Yasmin M Vasquez, Jennifer Wilkinson, Damian W Young, Stephen S Palmer, Kevin R Mackenzie, Choel Kim, Martin M Matzuk
Discovery Of Highly Potent And Alk2/Alk1 Selective Kinase Inhibitors Using Dna-Encoded Chemistry Technology, Ravikumar Jimmidi, Diana Monsivais, Hai Minh Ta, Kiran L Sharma, Kurt M Bohren, Srinivas Chamakuri, Zian Liao, Feng Li, John M Hakenjos, Jian-Yuan Li, Yuji Mishina, Haichun Pan, Xuan Qin, Matthew B Robers, Banumathi Sankaran, Zhi Tan, Suni Tang, Yasmin M Vasquez, Jennifer Wilkinson, Damian W Young, Stephen S Palmer, Kevin R Mackenzie, Choel Kim, Martin M Matzuk
Faculty, Staff and Students Publications
Activin receptor type 1 (ACVR1; ALK2) and activin receptor like type 1 (ACVRL1; ALK1) are transforming growth factor beta family receptors that integrate extracellular signals of bone morphogenic proteins (BMPs) and activins into Mothers Against Decapentaplegic homolog 1/5 (SMAD1/SMAD5) signaling complexes. Several activating mutations in ALK2 are implicated in fibrodysplasia ossificans progressiva (FOP), diffuse intrinsic pontine gliomas, and ependymomas. The ALK2 R206H mutation is also present in a subset of endometrial tumors, melanomas, non–small lung cancers, and colorectal cancers, and ALK2 expression is elevated in pancreatic cancer. Using DNA-encoded chemistry technology, we screened 3.94 billion unique compounds from our diverse …
Discovery Of Highly Potent And Alk2/Alk1 Selective Kinase Inhibitors Using Dna-Encoded Chemistry Technology, Ravikumar Jimmidi, Diana Monsivais, Hai Minh Ta, Kiran L Sharma, Kurt M Bohren, Srinivas Chamakuri, Zian Liao, Feng Li, John M Hakenjos, Jian-Yuan Li, Yuji Mishina, Haichun Pan, Xuan Qin, Matthew B Robers, Banumathi Sankaran, Zhi Tan, Suni Tang, Yasmin M Vasquez, Jennifer Wilkinson, Damian W Young, Stephen S Palmer, Kevin R Mackenzie, Choel Kim, Martin M Matzuk
Discovery Of Highly Potent And Alk2/Alk1 Selective Kinase Inhibitors Using Dna-Encoded Chemistry Technology, Ravikumar Jimmidi, Diana Monsivais, Hai Minh Ta, Kiran L Sharma, Kurt M Bohren, Srinivas Chamakuri, Zian Liao, Feng Li, John M Hakenjos, Jian-Yuan Li, Yuji Mishina, Haichun Pan, Xuan Qin, Matthew B Robers, Banumathi Sankaran, Zhi Tan, Suni Tang, Yasmin M Vasquez, Jennifer Wilkinson, Damian W Young, Stephen S Palmer, Kevin R Mackenzie, Choel Kim, Martin M Matzuk
Faculty, Staff and Students Publications
Activin receptor type 1 (ACVR1; ALK2) and activin receptor like type 1 (ACVRL1; ALK1) are transforming growth factor beta family receptors that integrate extracellular signals of bone morphogenic proteins (BMPs) and activins into Mothers Against Decapentaplegic homolog 1/5 (SMAD1/SMAD5) signaling complexes. Several activating mutations in ALK2 are implicated in fibrodysplasia ossificans progressiva (FOP), diffuse intrinsic pontine gliomas, and ependymomas. The ALK2 R206H mutation is also present in a subset of endometrial tumors, melanomas, non-small lung cancers, and colorectal cancers, and ALK2 expression is elevated in pancreatic cancer. Using DNA-encoded chemistry technology, we screened 3.94 billion unique compounds from our diverse …
Samd7 Represses Short-Wavelength Cone Genes To Preserve Long-Wavelength Cone And Rod Photoreceptor Identity, Leo I Volkov, Yohey Ogawa, Ramiz Somjee, Hannah E Vedder, Hannah E Powell, Deepak Poria, Sam Meiselman, Vladimir J Kefalov, Joseph C Corbo
Samd7 Represses Short-Wavelength Cone Genes To Preserve Long-Wavelength Cone And Rod Photoreceptor Identity, Leo I Volkov, Yohey Ogawa, Ramiz Somjee, Hannah E Vedder, Hannah E Powell, Deepak Poria, Sam Meiselman, Vladimir J Kefalov, Joseph C Corbo
2020-Current year OA Pubs
The role of transcription factors in photoreceptor gene regulation is fairly well understood, but knowledge of the cell-type-specific function of transcriptional cofactors remains incomplete. Here, we show that the transcriptional corepressor
Ethical Issues In Implementation Science: Perspectives From A National Heart, Lung, And Blood Institute Workshop, Neal W Dickert, Donna Spiegelman, Jennifer S Blumenthal-Barby, Garth Graham, Steven Joffe, Jeremy M Kahn, Nancy E Kass, Scott Y H Kim, Meeta P Kerlin, Aisha T Langford, James V Lavery, Daniel D Matlock, Kathleen N Fenton, George A Mensah
Ethical Issues In Implementation Science: Perspectives From A National Heart, Lung, And Blood Institute Workshop, Neal W Dickert, Donna Spiegelman, Jennifer S Blumenthal-Barby, Garth Graham, Steven Joffe, Jeremy M Kahn, Nancy E Kass, Scott Y H Kim, Meeta P Kerlin, Aisha T Langford, James V Lavery, Daniel D Matlock, Kathleen N Fenton, George A Mensah
Center for Medical Ethics and Health Policy Staff Publications
Ethical issues arise in the context of implementation science that may differ from those encountered in other research settings. This report, developed out of a workshop convened by the Center for Translation Research and Implementation Science within the United States National Heart, Lung, and Blood Institute, identifies six key themes that are important to the assessment of ethical dimensions of implementation science. First, addressing ethical challenges in implementation science does not require new ethical principles, commitments, or regulations. However, it does require understanding of the specific contexts arising in implementation research related to both study design and the intervention being …
Sims Rn Role In The Emergency Care Center - A New Approach To Delivering Quality Care, Jo Zarnegar
Sims Rn Role In The Emergency Care Center - A New Approach To Delivering Quality Care, Jo Zarnegar
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.
To Develop/Implement An Evidence Based Order Set For Maternity Patients With Potential Opioid Use Disorder (Oud), Katrina Munoz
To Develop/Implement An Evidence Based Order Set For Maternity Patients With Potential Opioid Use Disorder (Oud), Katrina Munoz
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.
Millennial Nurses Experience High Burnout And Turnover Risk During A Pandemic, Dana N Rutledge, Elizabeth Winokur, Sarah Douville
Millennial Nurses Experience High Burnout And Turnover Risk During A Pandemic, Dana N Rutledge, Elizabeth Winokur, Sarah Douville
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.
Road To Beacon Gold, Annika Daphne Bilog, Rhonda Tristan-Evans, Cecille Lamorena
Road To Beacon Gold, Annika Daphne Bilog, Rhonda Tristan-Evans, Cecille Lamorena
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.
Nurse-Led Interprofessional Pressure Injury Prevention In The Medical Intensive Care Unit, Chelsea Lannoo
Nurse-Led Interprofessional Pressure Injury Prevention In The Medical Intensive Care Unit, Chelsea Lannoo
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.
S.T.O.P. Drop It At The Door: Reducing Caregiver Burnout In The Emergency Room, Alexandra Rowen
S.T.O.P. Drop It At The Door: Reducing Caregiver Burnout In The Emergency Room, Alexandra Rowen
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.
Nurse Education On Icu Liberation To Improve Sedation Practices For Mechanical Ventilated Patients In Icu, Renae Sybesma
Nurse Education On Icu Liberation To Improve Sedation Practices For Mechanical Ventilated Patients In Icu, Renae Sybesma
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.
An Evidence-Based Quality Improvement Project To Decrease Fall Rates On Oncology, Susan Hampton-Ash
An Evidence-Based Quality Improvement Project To Decrease Fall Rates On Oncology, Susan Hampton-Ash
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.
Nurse Education On 4ps To Prevent Falls, Merri Lynn M. Anderson
Nurse Education On 4ps To Prevent Falls, Merri Lynn M. Anderson
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.
The Healthy Work Environment Model And New Graduate Nurses, Annika Daphne Bilog
The Healthy Work Environment Model And New Graduate Nurses, Annika Daphne Bilog
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.
Battling Compassion Fatigue, Burnout, And Nurse Retention, Nicole Raab
Battling Compassion Fatigue, Burnout, And Nurse Retention, Nicole Raab
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.
Breastfeeding Education Knowledge, Danielle Sees
Breastfeeding Education Knowledge, Danielle Sees
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.
Improving Oas Cahps Scores In Cv Prepost With Patient Education And Scripting, Marijoyce Dimatulac, Tessa Cicchella
Improving Oas Cahps Scores In Cv Prepost With Patient Education And Scripting, Marijoyce Dimatulac, Tessa Cicchella
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.
An Evidence-Based Quality Improvement Project To Improve Mobility In Medical Telemetry, Jacqueline Kimani
An Evidence-Based Quality Improvement Project To Improve Mobility In Medical Telemetry, Jacqueline Kimani
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.
Prevention Of Post-Pci Impella Bleeds, Maureen Maloney-Poldek
Prevention Of Post-Pci Impella Bleeds, Maureen Maloney-Poldek
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.
Enhancing Prenatal Breastfeeding Education To Improve Breastfeeding Rates, Angela Maietta
Enhancing Prenatal Breastfeeding Education To Improve Breastfeeding Rates, Angela Maietta
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.
Reducing Overutilization Of Telemetry On A Medical-Surgical Unit, Melrose Melgar
Reducing Overutilization Of Telemetry On A Medical-Surgical Unit, Melrose Melgar
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.
An Order Set For Maternity Patients With Potential Opioid Use Disorder, Katrina Munoz
An Order Set For Maternity Patients With Potential Opioid Use Disorder, Katrina Munoz
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.
Improving Door To Ct Time For Triage Patients, Christiane Pepitone
Improving Door To Ct Time For Triage Patients, Christiane Pepitone
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.
Improving Confidence Level Of The New Graduate Level Nurse And Nurse Fellows With Managing The Cardiac Arrest Patient, Charles Pfeiffer, Belinda N. Leos
Improving Confidence Level Of The New Graduate Level Nurse And Nurse Fellows With Managing The Cardiac Arrest Patient, Charles Pfeiffer, Belinda N. Leos
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.
The Effect Of Sleep Meditation Applications On Insomnia In Registered Nurses And Certified Nurse Assistants, Jaiden Tanaleon, Amy Hughes
The Effect Of Sleep Meditation Applications On Insomnia In Registered Nurses And Certified Nurse Assistants, Jaiden Tanaleon, Amy Hughes
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.
Use Of Agitation Scale Decision Scoring Grid To Improve Care Of Agitated/Anxious Patients In Dsu, Carmyle Seville, Angelica Taneca
Use Of Agitation Scale Decision Scoring Grid To Improve Care Of Agitated/Anxious Patients In Dsu, Carmyle Seville, Angelica Taneca
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.
Early Recognition Of Sepsis-Induced Hypotension In Dsu, Rebeca Zamora
Early Recognition Of Sepsis-Induced Hypotension In Dsu, Rebeca Zamora
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.
Impact Of Emergency Care Center Specialized Immediate Management Nurse On Quality Metrics, Jo Zarnegar
Impact Of Emergency Care Center Specialized Immediate Management Nurse On Quality Metrics, Jo Zarnegar
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.
Bhs Ubc, Romina Bobadilla
Bhs Ubc, Romina Bobadilla
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.