Medicine and Health Sciences Commons^™

Ofatumumab Associated Legionella Pneumonia In A Young Multiple Sclerosis Patient, Jobe Ashby, Md, Omar Pandhair

Articles, Abstracts, and Reports

2024-2025 PGY2

Bridging Care And Cost: Enhancing Communication In Hospital Settings By Incentivizing Electronic Medical Tools To Promote Value, Christinia Patel, Md, Shelley Schoepflin Sanders

Articles, Abstracts, and Reports

2024-2025 PGY3

Impact Of Injectable Calcitonin Non-Formulary Status On Treatment Of Hypercalcemia Of Malignancy In Hospitalized Patients, Ngoc Nguyen, Pamela Levine, Patricia Leo, Andrew Jarrell

Books, Presentations, Posters, Etc.

Purpose: Evidence suggests there is limited benefit in using injectable calcitonin for the treatment of hypercalcemia of malignancy. Based on this evidence and in the setting of increased drug costs, many institutions have opted to either restrict or remove calcitonin from their formulary. The purpose of this study was to describe the patient populations receiving treatment for hypercalcemia of malignancy and to evaluate the clinical and financial impact of injectable calcitonin being removed from formulary in an acute care setting. Methods: This retrospective cohort study was reviewed by the Providence Institutional Review Board. Patients were identified through EPIC electronic medical …

Assessment Of Appropriate Anticoagulation And Rates Of Bte In Ambulatory Oncology Patients Using A Validated Risk Assessment Model (Khorana Scote), David Page, Alan Su, Nikki Moxon, Staci Mellinger, Tracy L. Kelly, Katherine Lyon, Pharmd, Ian Ingram, Stephanie Matta, Pharmd, Bcop

Books, Presentations, Posters, Etc.

Abstract: Cancer associated venous thromboembolisms (VTE) are associated with higher health care resource utilization (number of hospitalizations, hospital length of stay, inpatient/outpatient medical services) and can complicate treatment of cancer. The Khorana Predictive Model for Chemotherapy-Associated VTE is a validated risk assessment model that determines a patient’s risk of developing VTEs and provides recommendations for starting prophylactic anticoagulation in ambulatory oncology patients. The Khorana Score is composed of various patient characteristics including site of primary cancer, prechemotherapy platelet count, hemoglobin level, prechemotherapy leukocyte count, and BMI. National Comprehensive Cancer Network (NCCN) supportive care guidelines recommend prophylactically starting an anticoagulant if …

Titratable, Weight-Based Cisatracurium Infusions For Ventilation Synchrony In Ards, Nanako Miimi, Pharmd, Celine Munoz

Books, Presentations, Posters, Etc.

Abstract: Cisatracurium is a non-depolarizing neuromuscular blocking agent used for paralysis in paitents with acute respiratory distress syndrome on mechanical ventilation. Paralysis prevents ventilator dyssynchrony and reduces patient’s work of breathing, which decreases the risk of pneumothorax. On November 1, 2023, PSVMC critical care units transitioned from fixed dosing of cisatracurium for ARDS to a weight-based, titratable dosing protocol. A single-center retrospective cohort study demonstrated cisatracurium titrated using train-of-four was associated with similar ventilatory and clinical outcomes with three folds reduction in cisatracrurium dose in comparison to fixed dose strategy. The purpose of this project is to evaluate the drug …

Extracorporeal Membrane Oxygenation (Ecmo) In Acute Chest Syndrome, Natalie Bolton, Md, Omar Pandhair

Articles, Abstracts, and Reports

2024-2025 PGY1

Diel Vertical Migration Rates Of The Dinoflagellate Species Margalefidinium Polykrikoides In A Lower Chesapeake Bay Tributary, S. Clayton, Jacqueline B. Chrabot, Michael Echevarria, Leah Gibala-Smith, Kathryn Mogatas, Peter Bernhardt, Margaret R. Mulholland

OES Faculty Publications

Margalefidinium polykrikoides is a mixotrophic dinoflagellate harmful algal bloom (HAB) species that blooms annually in the lower Chesapeake Bay. M. polykrikoides undertakes a diel vertical migration (DVM) which may give it a competitive advantage over purely phototrophic organisms who cannot access deeper nutrient pools and allow it to form large toxic blooms. Laboratory-based estimates of M. polykrikoides’ DVM rates suggest that it is one of the fastest known dinoflagellate swimmers and understanding this behavior is likely important for modeling and predicting M. polykrikoides blooms. However, to date, no field-derived estimates of M. polykrikoides’ DVM rates have been made in the …

Development Of Pesticide Labeling Literacy Scale In Thai Rice Farmer, Phiranut Saeneewong Na Ayuttaya

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research was designed as a mixed methods study that aimed to 1) develop and validate a pesticide labeling literacy scale for Thai rice farmers. and 2) evaluate the pesticide labeling literacy level by using the scale development among 400 Thai rice farmers in the central region of Pathum Thani, Chachoengsao, Suphan Buri, Nakhon Sawan, Chi Nat, Sing Buri, Uthai Thani, and Phra Nakhon Si Ayutthaya. The population was selected using a simple random sampling method. Descriptive statistics were used to analyze the general information of rice farmers. The factor analysis of the pesticide labeling literacy scale components (all 5 …

การศึกษาบทบาทพยาบาลผู้เชี่ยวชาญไตเทียม, อัมรินทร์ อรัญญกานนท์

Chulalongkorn University Theses and Dissertations (Chula ETD)

การศึกษานี้เป็นการศึกษาเชิงบรรยาย เพื่อศึกษาบทบาทพยาบาลผู้เชี่ยวชาญไตเทียม โดยใช้เทคนิคเดลฟาย ผู้ให้ข้อมูลคือผู้เชี่ยวชาญจำนวน 18 คน วิธีดำเนินการวิจัยประกอบด้วย 3 ขั้นตอน คือ ขั้นตอนที่ 1 สัมภาษณ์ผู้เชี่ยวชาญเกี่ยวกับบทบาทพยาบาลผู้เชี่ยวชาญไตเทียม ขั้นตอนที่ 2 นำข้อมูลที่ได้จากการสัมภาษณ์มาวิเคราะห์เนื้อหาแล้วสร้างเป็นแบบสอบถามให้ผู้เชี่ยวชาญประมาณค่าแนวโน้มความสำคัญของบทบาทพยาบาลผู้เชี่ยวชาญไตเทียม และขั้นที่ 3 นำข้อมูลที่ได้จากรอบที่ 2 มาคำนวณหาค่ามัธยฐาน ค่าพิสัยระหว่างควอไทล์ และส่งแบบสอบถามให้ผู้เชี่ยวชาญกลุ่มเดิมยืนยันคำตอบ จากนั้นจึงนำข้อมูลที่ได้มาคำนวณค่ามัธยฐาน และค่าพิสัยควอไทล์อีกครั้ง เพื่อสรุปเป็นบทบาทพยาบาลผู้เชี่ยวชาญไตเทียม ผลการวิจัยพบว่า บทบาทพยาบาลผู้เชี่ยวชาญไตเทียม ประกอบด้วย 6 บทบาท จำนวน 87 ข้อรายการ ดังนี้ 1) ด้านผู้ปฏิบัติการพยาบาลผู้เชี่ยวชาญไตเทียม จำนวน 40 ข้อ 2) ด้านผู้สอนและให้คำปรึกษา จำนวน 11 ข้อ 3) ด้านผู้ประสานงานและสื่อสาร จำนวน 7 ข้อ 4) ด้านผู้จัดการความปลอดภัยและบริหารความเสี่ยง จำนวน 10 ข้อ 5) ด้านผู้พัฒนาคุณภาพการพยาบาลการดูแลผู้ป่วยไตเทียม จำนวน 12 ข้อ และ6) ด้านผู้สร้างและใช้นวัตกรรมและเทคโนโลยี จำนวน 7 ข้อ

Distribution Pattern And Risk Factors Of Foot And Mouth Disease Outbreaks In Java Island, Indonesia, Virgilius Martin Kelake Kedang

Chulalongkorn University Theses and Dissertations (Chula ETD)

Indonesia experienced new outbreaks of foot and mouth disease (FMD) in 2022 after being officially free from the disease for several decades. The outbreak started in April 2022 in East Java and rapidly spread to many regions in Indonesia. This study aimed to investigate the distribution pattern and risk factors associated with the FMD outbreaks in Java Island, Indonesia, from 2022 to 2023. Descriptive, spatial, spatiotemporal, and risk factor analyses were employed to examine the outbreak dynamics and contributing factors. The results indicated that the outbreaks were distributed across the island, with East Java being the most affected region. The …

Epidemiological And Molecular Studies On Lumpy Skin Disease Outbreaks In Beef Cattle In Thailand During 2021-2022, Phurida Sripipattanakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Lumpy skin disease (LSD) is a vector-borne viral disease of cattle caused by the Lumpy skin disease virus (LSDV). LSD is considered as an emerging infectious disease in cattle in Asia and poses a significant threat to cattle production across Africa, Europe, and Asia. This study aimed to describe the epidemiological characteristics of LSD outbreaks in beef cattle in Thailand and to conduct a molecular survey of LSDV infection in beef cattle from May 2021 to December 2022. The study included 594 beef cattle from 257 farms affected by the LSD outbreaks in 28 provinces. We collected hair samples (n=492) …

Protein Expression Of Bone Marrow Mesenchymal Stem Cells Transfected On Green Fluorescent Protein Mrna And Collagen-Coated Titanium Disk, Wasamon Swangvong

Chulalongkorn University Theses and Dissertations (Chula ETD)

New strategies for surface modification have been explored to promote osseointegration and osteogenesis, which are crucial factors for the success of titanium dental implants. Coating the titanium surface with mRNA encoding therapeutic growth factors may achieve these objectives. In our pilot study, we employed green fluorescent protein (GFP) mRNA as a model. Our investigation focused on determining whether titanium disks coated with GFP mRNA encapsulated with lipid nanoparticles and collagen Type I (GFP mRNA-Col) could enhance transfection in human bone marrow mesenchymal stem cells (hBMSCs), in comparison to titanium disks coated with GFP mRNA alone, without collagen. We tested various …

Fusion Et Validation De Modèles Musculosquelettiques De La Colonne Lombaire Pour La Prévention Et La Réadaptation Des Travailleurs, Christian Larivière, Farshid Ghezelbash, Amir Eskandari, Denis Gagnon, Hakim Mecheri, Navid Arjmand, Aboulfazl Shirazi-Adl

Rapports de recherche scientifique

Les charges imposées sur la colonne vertébrale lombaire constituent un facteur de risque important pour les maux de dos. Connaître la distribution de ces forces internes lors d’activités de travail est nécessaire autant en prévention qu’en réadaptation des travailleurs. La modélisation musculosquelettique (MS) de la colonne vertébrale est la seule approche non invasive permettant d’estimer les charges sur les structures internes de la colonne.

Deux modèles ont été développés au Québec, soient un modèle par éléments finis (MEF) guidé par le mouvement et un autre guidé par des mesures électromyographiques (EMG) d’activation musculaire (modèle MEMG). Ces modèles sont donc sensibles …

Adaptation D’Outils Pour Soutenir Le Retour Progressif Au Travail, Marie-José Durand, Marie-France Coutu, Chantal Sylvain, Daniel Côté, Marie-Andrée Paquette

Rapports de recherche scientifique

L’incapacité au travail en raison de troubles musculosquelettiques (TMS) ou mentaux courants (TMC) affecte une portion importante de travailleurs et génère des coûts substantiels. La mise en œuvre de modalités de retour progressif au travail (RPAT) constitue un moyen efficace pour favoriser le retour et le maintien au travail des travailleurs concernés. Le Guide d’évaluation de la marge de manœuvre (GEMM) et l’Outil de retour progressif au travail (ORPAT) constituent des outils pertinents pour soutenir la pratique des professionnels de la santé et des milieux de travail à cet égard. Toutefois, leur utilisation dans la pratique demeure peu répandue et …

Étude De La Gestion De La Crise Sanitaire Liée À La Covid-19 Pour Soutenir La Transition Vers De Nouvelles Organisations Du Travail Dans Le Secteur De L’Administration Publique, Bénédicte Calvet, Martin Chadoin, Maud Gonella, Élise Ledoux, Denys Denis, Isabelle Berger

Rapports de recherche scientifique

La pandémie de la COVID-19 a surpris la population générale et a largement touché les milieux de travail qui ont dû se réorganiser. De nombreuses personnes se sont retrouvées en situation de télétravail imposé alors que d’autres, les travailleurs et travailleuses dits « essentiels » ont dû se conformer à de nombreuses restrictions sanitaires sur leur lieu de travail. Face à l’urgence, plusieurs guides et outils ont été diffusés auprès des entreprises de plusieurs secteurs d’activité économique, afin de les soutenir dans la mise en place de mesures en santé et en sécurité du travail (SST) conformes au contexte pandémique, …

Exposition Professionnelle Des Femmes Aux Substances Chimiques : Amélioration D’Une Matrice Emploi Exposition Existante Pour Fournir Des Estimations Spécifiques Au Sexe : Rapport Abrégé, Vikki Ho, Chelsea Almadin, France Labrèche, Mark Goldberg, Marie-Élise Parent, Jack Siemiatycki, Jérôme Lavoué

Rapports de recherche scientifique

Il est reconnu que les femmes et les hommes ont des profils professionnels différents qui peuvent donc se traduire par des risques de maladie professionnelle différents. Pourtant, la plupart de nos connaissances actuelles sur les maladies professionnelles découlent d'études menées auprès des hommes. Or, les femmes représentent actuellement 48 % de la population active au Québec. La santé des femmes dans l’environnement de travail demeure un domaine sous-étudié et nous sommes particulièrement freinés par le manque de compréhension de l'impact du genre sur l'exposition en milieu de travail. Il a été démontré que l'attribution des tâches et les conditions de …

Occupational Exposures Of Women To Chemical Substances: Improvement Of An Existing Job Exposure Matrix To Provide Sex-Specific Estimations Of Exposure, Vikki Ho, Chelsea Almadin, France Labrèche, Mark Goldberg, Marie-Élise Parent, Jack Siemiatycki, Jérôme Lavoué

Rapports de recherche scientifique

Il est reconnu que les femmes et les hommes ont des profils professionnels différents qui peuvent donc se traduire par des risques de maladie professionnelle différents. Pourtant, la plupart de nos connaissances actuelles sur les maladies professionnelles découlent d'études menées auprès des hommes. Or, les femmes représentent actuellement 48 % de la population active au Québec. La santé des femmes dans l’environnement de travail demeure un domaine sous-étudié et nous sommes particulièrement freinés par le manque de compréhension de l'impact du genre sur l'exposition en milieu de travail. Il a été démontré que l'attribution des tâches et les conditions de …

Quantification Of Antiviral Drug Tenofovir (Tfv) By Surface-Enhanced Raman Spectroscopy (Sers) Using Cumulative Distribution Functions (Cdfs), Marguerite R. Butler, Jana Hrncirova, Meredith Clark, Sucharita Dutta, John B. Cooper

Chemistry & Biochemistry Faculty Publications

Surface-enhanced Raman spectroscopy (SERS) is an ultrasensitive spectroscopic technique that generates signal-enhanced fingerprint vibrational spectra of small molecules. However, without rigorous control of SERS substrate active sites, geometry, surface area, or surface functionality, SERS is notoriously irreproducible, complicating the consistent quantitative analysis of small molecules. While evaporatively prepared samples yield significant SERS enhancement resulting in lower detection limits, the distribution of these enhancements along the SERS surface is inherently stochastic. Acquiring spatially resolved SERS spectra of these dried surfaces, we have shown that this enhancement is governed by a power law as a function of analyte concentration. Consequently, by definition, …

Exploration Of Potential Broad-Spectrum Antiviral Targets In The Enterovirus Replication Element: Identification Of Six Distinct 5' Cloverleaves, Morgan G. Daniels, Meagan E. Werner, Rockwell T. Li, Steven M. Pascal

Chemistry & Biochemistry Faculty Publications

Enterovirus genomic replication initiates at a predicted RNA cloverleaf (5′CL) at the 5′ end of the RNA genome. The 5′CL contains one stem (SA) and three stem-loops (SLB, SLC, SLD). Here, we present an analysis of 5′CL conservation and divergence for 209 human health-related serotypes from the enterovirus genus, including enterovirus and rhinovirus species. Phylogenetic analysis indicates six distinct 5′CL serotypes that only partially correlate with the species definition. Additional findings include that 5′CL sequence conservation is higher between the EV species than between the RV species, the 5′CL of EVA and EVB are nearly identical, and RVC has the …

Reiq-Mediated Alarmone Signalling Regulates Growth, Stress-Induced Biofilm Formation And Spore Accumulation In Clostridioides Difficile, Areej Malik, Adenrele Oludiran, Asia Poudel, Orlando Berumen Alvarez, Charles Woodward, Erin B. Purcell

Chemistry & Biochemistry Faculty Publications

The bacterial stringent response (SR) is a conserved transcriptional reprogramming pathway mediated by the nucleotide signalling alarmones, (pp)pGpp. The SR has been implicated in antibiotic survival in Clostridioides difficile, a biofilm- and spore-forming pathogen that causes resilient, highly recurrent C. difficile infections. The role of the SR in other processes and the effectors by which it regulates C. difficile physiology are unknown. C. difficile RelQ is a clostridial alarmone synthetase. Deletion of relQ dysregulates C. difficile growth in unstressed conditions, affects susceptibility to antibiotic and oxidative stressors and drastically reduces biofilm formation. While wild-type C. difficile displays increased biofilm …

Measured Air Quality Impacts After Teaching Parents About Cooking Ventilation With A Video: A Pilot Study, Stephanie M. Holm, Brett C. Singer, Mi-Suk Kang Dufour, Woody Delp, James E. S. Nolan, P. Jacob Bueno De Mesquita, Et Al.

Arts & Sciences Faculty Publications

Background

Cooking-related emissions contribute to air pollutants in the home and may influence children’s health outcomes.

Objective

In this pilot study, we investigate the effects of a cooking ventilation intervention in homes with gas stoves, including a video-based educational intervention and range hood replacement (when needed) in children’s homes.

Methods

This was a pilot (n = 14), before-after trial (clinicaltrials.gov #NCT04464720) in homes in the San Francisco Bay Area that had a school-aged child, a gas stove, and either a venting range hood or over-the-range microwave/hood. Cooking events, ventilation use, and indoor air pollution were measured in homes for …

Germicidal Ultraviolet (Guv): A Powerful Tool For Improving Indoor Air Quality And Reducing Disease Transmission, P. Jacob Bueno De Mesquita

Arts & Sciences Faculty Publications

No abstract provided.

High Prevalence Of Trypanosoma Cruzi Infection In Raccoons (Procyon Lotor) And Associated Risk To Humans In Central Illinois, Esther Onuselogu

Masters Theses

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, remains a neglected tropical disease and a growing health threat in the United States. Raccoons (Procyon lotor) often coexist with humans in urban and suburban areas and serve as reservoir hosts for T. cruzi. While T. cruzi is rare in humans and domestic animals in the U.S., it is common in wildlife species, particularly raccoons and Virginia opossums (Didelphis virginiana). This study aimed to assess the prevalence of T. cruzi infection in the raccoon population of Central Illinois and evaluate the risk of transmission to humans. …

The Role Of Liver-Specific Transcription Factor Hnf4 In Reprogramming Of Fibroblasts, Mary Odubote

Masters Theses

The mammalian liver, a vital organ with complex functions, relies on a network of transcription factors to regulate gene expression. Fusion of hepatoma cells with fibroblasts often leads to gene extinction, silencing approximately 400 liver-enriched genes, including critical transcription factors such as HNF4. Previous studies revealed that ectopic expression of HNF4 in fibroblasts failed to prevent the extinction of SERPINA1, a liver-specific gene, upon subsequent fusion with hepatoma cells. Here, we sought to investigate the extent to which ectopic expression of HNF4 can reprogram fibroblast cells and prevent gene extinction in hybrid cells.

Using whole-genome expression analysis, we compared RAT1 …

Variability In Perceptions Of Complementary Health Approaches Among Graduate Student Trainees, Delaney C. Bilodeau

Theses and Dissertations

Complementary Health Approaches (CHAs) encompass a diverse range of practices which are often used both independently and alongside conventional medical treatments. Understanding how graduate students training in different fields perceive CHAs is important because these professional trainees will go on to occupy roles as healthcare practitioners, researchers, policy makers, and consumers. This study used sequential rank agreement methods (Ekstrøm, Gerds, & Jensen, 2019) to investigate variations in perceptions of CHAs in a sample of graduate students (N = 416) from 140 possible training programs. Ratings of CHA familiarity, perceptions of CHA legitimacy, and willingness to recommend CHAs were compared …

Investigation Of Brain Function And Structural Development As Risk Factors Of Suicidal Thoughts And Behaviors, Yi Zhou

Theses and Dissertations

Background: Identifying risk factors for suicidal thoughts and behaviors, especially causal ones, will be imperative to improving screening and treatment interventions. To identify replicable brain-based risk factors, there is increasing evidence indicating the need for large sample sizes, in the hundreds to thousands, in order to achieve a sufficient level of statistical power to detect them. Furthermore, longitudinal studies of brain and behavioral factors will be essential to understanding how suicide develops, especially the transition from suicide ideation to attempt. While experimental studies may not be feasible or ethical, genetically informed methods for testing evidence for causation are an alternative …

Prosthetic Attention In Upper Limb Loss: User Experiences, Clinical Perceptions, And Developing Candidate Items, Tanu Bhargava

Theses and Dissertations

The human hand is a powerful tool essential for performing a range of tasks from simple to complex, and it plays a crucial role in social interactions and environmental engagement. Upper limb (UL) loss disrupts these functions and significantly impacts daily life. Prosthetic devices can partially restore these abilities and improve quality of life, but they lack the intuitive control and sensory feedback of natural hands. Consequently, operating a UL prosthesis requires substantial attentional demands, a factor that potentially contributes to high rates of device dissatisfaction and disuse. For UL prosthesis users, managing attentional resources is critical to efficiently controlling …

The Role Of Hdac6 In Periodontal Inflammation, Hannah S. Lohner

Theses and Dissertations

Periodontal disease is a polymicrobial infection-induced chronic inflammatory disease and results in irreversible tissue damage and bone loss. While bacteria play a large role in the initiation of this disease, excessive and prolonged inflammatory immune responses are fundamental for its progression, making host directed therapy (HDT) a possible and potentially valuable treatment. Histone Deacetylase 6 (HDAC6) is an enzyme that removes acetyl groups from both histone and non-histone proteins, giving it a potential role in regulating inflammation initiated by pathogenic oral bacteria. Previous studies indicated that HDACs act as a bivalent regulator in inflammatory responses; however, the role that HDAC6 …

The Effect Of Local Anesthesia When Used In Dental Restorative Cases Under General Anesthesia On Control Of Postoperative Comfort, Elizabeth S. Kleefisch Dds

Theses and Dissertations

Purpose:

To determine the effect of local anesthesia on postoperative comfort in patients undergoing dental care under general anesthesia.

Methods:

This study was modeled as a double-blinded randomized control trial. Patients included healthy children under the age of 6 years scheduled for restorative dental treatment under general anesthesia (GA). Patient behavior was evaluated preoperatively and postoperatively using the Faces, Legs, Activity, Cry and Consolability (FLACC) or other pain score and postoperatively using the Parent’s Postoperative Pain Measure (PPPM). Intraoperatively, participants followed a standardized general anesthesia protocol and were given either local anesthetic (LA) infiltration using 2% Lidocaine 1:100,000 Epinephrine by …

An Examination Of Hiring Practices And Employee Retention Today Compared With Pre-Pandemic Characteristics In Orthodontics, Logan Passey

Theses and Dissertations

Purpose: Evaluate current hiring practices and employee retention characteristics in orthodontic private practices.

Methods: Orthodontists (n=1000) were surveyed regarding their hiring methods and outcomes. Responses were summarized with descriptive statistics. Chi-square tests were used to compare hiring practices and perceptions. Nonparametric Kruskal-Wallis tests were utilized in analysis of retention thresholds.

Results: Survey response rate was 7.2% (72 responses). When comparing thresholds previous to, and after the COVID-19 pandemic, there was an increase in open clinical positions compared with non-clinical and managerial positions (p=.0008). 68% of orthodontists reported a decrease in qualified applications for clinical positions compared with non-clinical and managerial …