Medicine and Health Sciences Commons^™

Conflict With Peer: Poor Peer Participation, Alexa Bernard, Elli Johnson, Jackson Ferris, Jose Lopez, Susan Hartzell, Theodore Schiff, Amanah Fatima

Patient Education Projects

No abstract provided.

Conflict With Peer: Struggling Colleague, Andrew Lemmen, Daniel Saxon, Devun Birk, Shrila Rajendran, Timothy Li, Ayman Salem

Patient Education Projects

No abstract provided.

Conflict With Peer: Peer’S Lack Of Preparedness, Jacob Waitzman, Isabella Anton, Parnia Behinaein, Patrick Kollman, Samy Shelbaya, Yage Pi, Mariam Raheem

Patient Education Projects

No abstract provided.

Conflict With Peer: Treatment Plan Disagreement, Dhiraj Tadikamalla, Lara Rostomian, Meet Patel, Neil Garg, Sara Naessig, Sohini Pandit, Mariam Raheem

Patient Education Projects

No abstract provided.

Group Reflection: White Coat And Physician-Patient Relationship, Emily Smith, Joseph Mccormick, Lukas Biel, Melissa Elmali, Mura Abdul-Nabi, Nitya Deshpande, Sahalia Rashid

Patient Education Projects

No abstract provided.

Group Reflection: Confidence And Functioning In A Medical Team, Anisha Patel, Annelise Gordon, Jonathan Toma, Maximilian Wehner, Rohit Goru, Amanah Fatima

Patient Education Projects

No abstract provided.

Group Reflection: White Coat As A Symbol Of Trust, Ahmed Jafri, Brianna Regan, Maya Kohavi, Tareq Hanna, Zarin Kothari, Amanah Fatima, Fadi Kathawa

Patient Education Projects

No abstract provided.

Group Reflection: Different Interpretations The White Coat Has On Patients, Arainya Durham, Jacob Hall, James Soetedjo, Khush Hussain, Samantha Markowitz, Shruthi Ilango, Amanah Fatima, Fadi Kathawa

Patient Education Projects

No abstract provided.

Group Reflection: White Coat As A Symbol Of Healing, Constance Cleveland, Deepa Raghavan, Dipra Debnath, Jay Maixner, Ranya Krayem, Vikash Mehan, Zane Mustafa, Ayman Salem

Patient Education Projects

No abstract provided.

Group Reflection: Being Cognizant Of The Dichotomy The White Coat Holds, Demetrius Moncrease, Parshva Salvi, Basel Mhaimeed, Fadumo Yusuf, Marissa Yaldo, Sneha Bhargava, Kenan Abou Chaer, Astha Saini

Patient Education Projects

No abstract provided.

Group Reflection: White Coat As A Sense Of Belonging, Era Cobani, Angelica Cabatu, Carly Abrahams, Curtis Mack, Michal Ruprecht, Nicholas Apostolakis, Mariam Raheem

Patient Education Projects

No abstract provided.

Conflict With Peer: Late Group Mate, Constance Cleveland, Deepa Raghavan, Dipra Debnath, Jay Maixner, Ranya Krayem, Vikash Mehan, Zane Mustafa, Ayman Salem

Patient Education Projects

No abstract provided.

Meta-Narrative Synthesis: The Effectiveness Of Diagnosing And Treating Melanoma With Micrographically Oriented Histograph Surgery Mohs Technique, Gabriella Casas Ms, Nida Mubeen Ms, Nicole Rivera Ms, Tan Thien Tang Mr., Mark A. Bailey Mr, Mary Coolbaugh-Murphy, Denise M. Juroske Short Mrs

Research Methods Poster Session 2024

This meta-narrative synthesis highlights the effectiveness of diagnosing and treating melanoma with Micrographically Oriented Histography Surgery (MOHS) technique. Initiating the questions: What techniques does MOHS surgery involve when diagnosing and treating non-metastasized Melanoma? How will it provide positive outcomes for the patient? The significance of using MOHS excision technique and diagnosis of localized facial melanoma compared to traditional cancer excision techniques is designed to remove affected tissue while preserving anatomical facial structure in an aesthetic fashion. Providing an overview of the technique’s diagnostic professional capabilities as well as its strengths, limitations, improvement for upcoming studies, and potential prognosis. Melanoma, a …

Efficacy And Safety Of Once-Weekly Insulin Regimes On Glycemic Control For Type 2 Diabetes: A Systematic Review And Network Meta-Analysis, Peng Wang, Yu Zhang, Wenhao Xu, Liyuan Peng, Ping Xu, Weelic Chong, Yang Hai, Lu Jia, Fang Fang

Student Papers, Posters & Projects

Background

Randomized controlled trials have found that once-weekly insulin resulted in greater glycemic control compared to once-daily insulin in patients with type 2 diabetes. However, no direct comparisons have been made between different types of once-weekly insulin thus far. This systematic review and network meta-analysis aimed to evaluate the effect of the two most advanced once-weekly insulin analogues, namely insulin icodec and insulin Fc, in patients with type 2 diabetes.

Methods

We conducted a thorough search in the databases PubMed, Embase, and the Cochrane Central Register of Controlled Trials. The search included articles published from the beginning to October 10, …

20240103_A Warm Welcome, Laura J. Hall

HSLIC Blog Post

No abstract provided.

Targeting Dna Repair And Survival Signaling In Diffuse Intrinsic Pontine Gliomas To Prevent Tumor Recurrence, Monika Sharma, Ivana Barravecchia, Robert Teis, Jeanette Cruz, Rachel Mumby, Elizabeth K Ziemke, Carlos E Espinoza, Varunkumar Krishnamoorthy, Brian Magnuson, Mats Ljungman, Carl Koschmann, Joya Chandra, Christopher E Whitehead, Judith S Sebolt-Leopold, Stefanie Galban

Faculty, Staff and Student Publications

Therapeutic resistance remains a major obstacle to successful clinical management of diffuse intrinsic pontine glioma (DIPG), a high-grade pediatric tumor of the brain stem. In nearly all patients, available therapies fail to prevent progression. Innovative combinatorial therapies that penetrate the blood-brain barrier and lead to long-term control of tumor growth are desperately needed. We identified mechanisms of resistance to radiotherapy, the standard of care for DIPG. On the basis of these findings, we rationally designed a brain-penetrant small molecule, MTX-241F, that is a highly selective inhibitor of EGFR and PI3 kinase family members, including the DNA repair protein DNA-PK. Preliminary …

Enrichment Of Polycyclic Aromatic Hydrocarbon Metabolizing Microorganisms On The Oral Mucosa Of Tobacco Users, James V. Defrancesco, Lin Tao, M Paul Chiarelli, Sylvia Pavlova, Antonia Kolokythas, Joel Schwartz, Benjamin Salameh, Stefan J. Green, Guy Adami

Chemistry: Faculty Publications and Other Works

Certain soil microbes resist and metabolize polycyclic aromatic hydrocarbons (PAHs). The same is true for a subset of skin microbes. In the human mouth, oral microbes have the potential to oxidize tobacco PAHs, thereby increasing these chemicals' ability to cause cancer of adjacent epithelium. We hypothesized that we could identify, in smokers, the oral mucosal microbes that can metabolize PAH. We isolated bacteria and fungi that survived long-term in minimal media with PAHs as the sole carbon source, under aerobic conditions, from the oral mucosa in 17 of 26 smokers and two of 14 nonsmokers. Of bacteria genera that survived …

An Evolutionary Perspective On Complex Neuropsychiatric Disease, Jon M Mcclellan, Anthony W Zoghbi, Joseph D Buxbaum, Carolina Cappi, James J Crowley, Jonathan Flint, Dorothy E Grice, Suleyman Gulsuner, Conrad Iyegbe, Sanjeev Jain, Po-Hsiu Kuo, Maria Claudia Lattig, Maria Rita Passos-Bueno, Meera Purushottam, Dan J Stein, Anna B Sunshine, Ezra S Susser, Christopher A Walsh, Olivia Wootton, Mary-Claire King

Faculty, Staff and Students Publications

The forces of evolution-mutation, selection, migration, and genetic drift-shape the genetic architecture of human traits, including the genetic architecture of complex neuropsychiatric illnesses. Studying these illnesses in populations that are diverse in genetic ancestry, historical demography, and cultural history can reveal how evolutionary forces have guided adaptation over time and place. A fundamental truth of shared human biology is that an allele responsible for a disease in anyone, anywhere, reveals a gene critical to the normal biology underlying that condition in everyone, everywhere. Understanding the genetic causes of neuropsychiatric disease in the widest possible range of human populations thus yields …

Age- And Sex-Specific Normative Values For Muscle Mass Parameters In 18,625 Brazilian Adults., Hélio José Coelho-Júnior, Fillipi Lopes Marques, Caio Victor Sousa, Emanuele Marzetti, Samuel Da Silva Aguiar

Health and Human Sciences Faculty Works

Background: The present study aimed to provide age- and sex-specific normative values for muscle mass parameters in Brazilian adults.

Methods: Data pertaining to Brazilian adults (18+ years) who attended a nutritional clinical between January 2018 and July 2022 were analyzed. Muscle mass parameters were assessed using a bioimpedance digital scale (InBody 230, GBC BioMed NZ). Assessments were conducted under standard conditions, with participants refraining from physical exercise for 96 h and from eating or drinking (including water) for 8 h before evaluations.

Results: A total of 18,625 Brazilian adults were analyzed. Normative values for absolute and relative (height, m^{2 …}

The Barriers To Adult Play In Graduate Students, Rosalind Nolde, Catherine Salomon, T. Monelli, Sabrina Solis

Occupational Therapy | Graduate Student Research Posters

The purpose of this study is to expand the knowledge of barriers to play for graduate students. The research question asked, what are the barriers to play experienced by graduate students? Play is a complex term that is unique to the individual. Although subjective, existing literature gives suggestions as to what play can mean or feel like to the individual participating. Brown (2009), notes that the definition of play should be experienced rather than defined as it is distinctive to each individual. Van Vleet and Feeney (2015) describe play as being the purpose of amusement, fun or to have energetic, …

Heat Shock Factor 1 Directly Regulates Transsulfuration Pathway To Promote Prostate Cancer Proliferation And Survival, J Spencer Hauck, David Moon, Xue Jiang, Mu-En Wang, Yue Zhao, Lingfan Xu, Holly Quang, William Butler, Ming Chen, Everardo Macias, Xia Gao, Yiping He, Jiaoti Huang

Faculty, Staff and Students Publications

There are limited therapeutic options for patients with advanced prostate cancer (PCa). We previously found that heat shock factor 1 (HSF1) expression is increased in PCa and is an actionable target. In this manuscript, we identify that HSF1 regulates the conversion of homocysteine to cystathionine in the transsulfuration pathway by altering levels of cystathionine-β-synthase (CBS). We find that HSF1 directly binds the CBS gene and upregulates CBS mRNA levels. Targeting CBS decreases PCa growth and induces tumor cell death while benign prostate cells are largely unaffected. Combined inhibition of HSF1 and CBS results in more pronounced inhibition of PCa cell …

The Use Of Cardiac Magnetic Resonance In Hypertrophic Cardiomyopathy Over The Past 10 Years [2013-2023]: A Citespace-Based Bibliometric Analysis, Mengyao Hu, Yu Shen, Yipei Song, Shuhao Li, Pei Yang, Ao Kan, Qiming Fang, Yun Peng, Haibo Ren, Yajing Zhang, Lianggeng Gong

Faculty, Staff and Student Publications

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a common genetic cardiac disorder characterized by the hypertrophy of a segment of the myocardium. Cardiac magnetic resonance (CMR) has been widely used in the assessment of HCM. However, no bibliometric assessment has been conducted on the progress of research in this field. This study thus aimed to examine the current state of research into the application of CMR in HCM and the hotspots and trends that have emerged in this field over the past decade.

METHODS: A systematic search was conducted on the Web of Science regarding CMR in the assessment of HCM. The …

Postoperative Systemic Inflammatory Response Syndrome Predicts Increased Mortality In Patients After Elective Craniotomy, Liyuan Peng, Qi Gan, Yangchun Xiao, Jialing He, Xin Cheng, Peng Wang, Lvlin Chen, Tiangui Li, Yan He, Weelic Chong, Yang Hai, Chao You, Fang Fang, Yu Zhang

Department of Medical Oncology Faculty Papers

Introduction: Patients undergoing craniotomy are at high risk of perioperative morbidity and mortality due to excessive inflammatory responses. The purpose of the present study is to evaluate the prognostic utility of postoperative systemic inflammatory response syndrome (SIRS) in patients undergoing craniotomy.

Methods: We performed a retrospective cohort study of patients who underwent craniotomy between January 2011 and March 2021. SIRS was diagnosed based on two or more criteria (hypo-/hyperthermia, tachypnea, leukopenia/leukocytosis, tachycardia). We used univariate and multivariate analysis for the development of SIRS with postoperative 30-day mortality.

Results: Of 12,887 patients who underwent craniotomy, more than half of the patients …

Mir126-Targeted-Nanoparticles Combined With Pi3k/Akt Inhibitor As A New Strategy To Overcome Melanoma Resistance, Maria Beatrice Arasi, Gabriele De Luca, Laura Chronopoulou, Francesca Pedini, Eleonora Petrucci, Michela Flego, Annarita Stringaro, Marisa Colone, Luca Pasquini, Massimo Spada, Valentina Lulli, Maria Chiara Perrotta, George Adrian Calin, Cleofe Palocci, Mauro Biffoni, Federica Felicetti, Nadia Felli

Faculty, Staff and Student Publications

Metastatic melanoma poses significant challenges as a highly lethal disease. Despite the success of molecular targeting using BRAFV600E inhibitors (BRAFis) and immunotherapy, the emergence of early recurrence remains an issue and there is the need for novel therapeutic approaches. This study aimed at creating a targeted delivery system for the oncosuppressor microRNA 126 (miR126) and testing its effectiveness in combination with a phosphatidylinositol 3-kinase (PI3K)/ protein kinase B (AKT) inhibitor for treating metastatic melanoma resistant to BRAFis. To achieve this, we synthesized chitosan nanoparticles containing a chemically modified miR126 sequence. These nanoparticles were further functionalized with an antibody specific to …

Impact Of Opioid-Free Analgesia On Pain Severity And Patient Satisfaction After Discharge From Surgery: Multispecialty, Prospective Cohort Study In 25 Countries, Tasman Collaborative

Faculty, Staff and Student Publications

BACKGROUND: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.

METHODS: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview …

Class Ii Hla-Drb4 Is A Predictive Biomarker For Survival Following Immunotherapy In Metastatic Non-Small Cell Lung Cancer, Cindy Y Jiang, Lili Zhao, Michael D Green, Shashidhar Ravishankar, Andrea M H Towlerton, Anthony J Scott, Malini Raghavan, Matthew F Cusick, Edus H Warren, Nithya Ramnath

Faculty, Staff and Student Publications

Immune checkpoint inhibitors (ICI) are important treatment options for metastatic non-small cell lung cancer (mNSCLC). However, not all patients benefit from ICIs and can experience immune-related adverse events (irAEs). Limited understanding exists for germline determinants of ICI efficacy and toxicity, but Human Leukocyte Antigen (HLA) genes have emerged as a potential predictive biomarker. We performed HLA typing on 85 patients with mNSCLC, on ICI therapy and analyzed the impact of HLA Class II genotype on progression free survival (PFS), overall survival (OS), and irAEs. Most patients received pembrolizumab (83.5%). HLA-DRB4 genotype was seen in 34/85 (40%) and its presence correlated …

Group Reflection: Barrier Of The White Coat, Abrielle Fretz, Anusha Vavilikolanu, Cassandra Pecarski, Daphne Pate, Peter Nolan, Trisha Ray, Wassim Mohamad-Said

Patient Education Projects

No abstract provided.

Conflict With Administrators: Patient Scheduling, Anastasia Goldbaum, Austin Kim, Cole Sabinash, Gabrielle Cowen, Kassim Salami, Simran Brar, Sahalia Rashid

Patient Education Projects

No abstract provided.

Conflict With Administrators: Scheduling Conflicts With Administration, Constance Cleveland, Deepa Raghavan, Dipra Debnath, Jay Maixner, Ranya Krayem, Vikash Mehan, Zane Mustafa, Ayman Salem

Patient Education Projects

No abstract provided.

Conflict With Administrators: Administrator Makes An Offensive Or Inappropriate Comment, Emily Smith, Joseph Mccormick, Lukas Biel, Melissa Elmali, Mura Abdul-Nabi, Nitya Deshpande, Sahalia Rashid

Patient Education Projects

No abstract provided.