Medicine and Health Sciences Commons^™

Doxycycline For Transgene Control Disrupts Gut Microbiome Diversity Without Compromising Acute Neuroinflammatory Response, Emily J Koller, Caleb A Wood, Zoe Lai, Ella Borgenheimer, Kristi L Hoffman, Joanna L Jankowsky

Faculty, Staff and Students Publications

The tetracycline transactivator (tTA) system provides controllable transgene expression through oral administration of the broad-spectrum antibiotic doxycycline. Antibiotic treatment for transgene control in mouse models of disease might have undesirable systemic effects resulting from changes in the gut microbiome. Here we assessed the impact of doxycycline on gut microbiome diversity in a tTA-controlled model of Alzheimer's disease and then examined neuroimmune effects of these microbiome alterations following acute LPS challenge. We show that doxycycline decreased microbiome diversity in both transgenic and wild-type mice and that these changes persisted long after drug withdrawal. Despite the change in microbiome composition, doxycycline treatment …

Low Rna Disruption During Neoadjuvant Chemotherapy Predicts Pathologic Complete Response Absence In Patients With Breast Cancer, Marina Elena Cazzaniga, Foluso Ademuyiwa, Et Al.

2020-Current year OA Pubs

In previously reported retrospective studies, high tumor RNA disruption during neoadjuvant chemotherapy predicted for post-treatment pathologic complete response (pCR) and improved disease-free survival at definitive surgery for primary early breast cancer. The BREVITY (Breast Cancer Response Evaluation for Individualized Therapy) prospective clinical trial (NCT03524430) seeks to validate these prior findings. Here we report training set (Phase I) findings, including determination of RNA disruption index (RDI) cut points for outcome prediction in the subsequent validation set (Phase II; 454 patients). In 80 patients of the training set, maximum tumor RDI values for biopsies obtained during neoadjuvant chemotherapy were significantly higher in …

Liquefied Petroleum Gas Or Biomass Cooking And Severe Infant Pneumonia, Eric D. Mccollum, Victor G. Davila-Roman, Lindsay J. Underhill, Et Al.

2020-Current year OA Pubs

No abstract provided.

Sensory Neurons Promote Immune Homeostasis In The Lung, Masato Tamari, Aaron M Ver Heul, Masato Hoshi, Anna M Trier, Ting-Lin Yang, Sanjay Jain, Steven Van Dyken, Et Al.

2020-Current year OA Pubs

Cytokines employ downstream Janus kinases (JAKs) to promote chronic inflammatory diseases. JAK1-dependent type 2 cytokines drive allergic inflammation, and patients with JAK1 gain-of-function (GoF) variants develop atopic dermatitis (AD) and asthma. To explore tissue-specific functions, we inserted a human JAK1 GoF variant (JAK1

Thinking Outside The Box For Experiential Student Learning: Development Of Remote Experiential Learning And Volunteering During The Pandemic, Amy Christopher

Learning Teaching Forum

In response to the COVID-19 pandemic, experiential learning for health care professional programs struggled to find clinical rotation sites and provide students in the didactic curricular phase opportunities to apply health education outside of the classroom. Many healthcare sites and community health screening events were prohibited during an extended period of time due to pandemic isolation. As a health educator, exploration of remote experiential learning took creative planning to ensure students were able to apply their medical knowledge in real-life situations, give back to their community according to Marianist charisms, and fulfill healthcare-related volunteer service hour requirements.

More information in …

Medical School Watercooler Newsletter - January 3, 2024, Lindsey Lyle

Watercooler Newsletter

This is the January 3, 2024 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Meet a Med Student: Avery Silar
• Pediatric ear, nose and throat specialist joins faculty
• Brewer returns to Whiddon COM as interim chair of orthopaedic surgery
• Group to focus on climate and health in Alabama

Conflict With Peer: Workload Sharing, Alyssa Fabrizio, Elnaz Guivatchian, Joshua Rayham, Nico-Luis Ayala, Nikolas Minanov, Sidney Caudell, Sahalia Rashid, Rahul Vyas

Patient Education Projects

No abstract provided.

The Sensory Accommodation Framework For Technology: Bridging Sensory Processing To Social Cognition, Louanne Boyd

Engineering Faculty Books and Book Chapters

This book provides a thorough introduction to the many facets of designing technologies for autism, with a particular focus on optimizing visual attention frameworks. This book is designed to provide a detailed overview of several aspects of technology for autism. Each Chapter illustrates different parts of the Sensory Accommodation Framework and provides examples of relevant available technologies. The books first discusses a variety of skills that make up human development as well as a history of autism as a diagnosis and the birth of the neurodiversity movement. It goes on to detail individual types of therapy and how they interact …

Conflict With Patient: Late Physician And Patient Wait Time, Anisha Patel, Annelise Gordon, Jonathan Toma, Maximilian Wehner, Rohit Goru, Amanah Fatima

Patient Education Projects

No abstract provided.

Conflict With Patient: Disrespectful Patient, Breanna Ramsey, Michelle Chung, Nevil Khurana, Olivia Decker, Riley Wistrom, Sinyu Yang, Wassim Mohamad-Said

Patient Education Projects

No abstract provided.

Conflict With Peer: Handling Microaggressions, Desiree Duncan, Hazem Alata, Kyle O'Hollaren, Kyriacos Vlachos, Nicole Oska, Rebecca Cameron, Sahalia Rashid

Patient Education Projects

No abstract provided.

Conflict With Peer: Late Team Member, Alexander Minos, Carline Dugue, Ethan Mathew, Katherine Sommers, Lauren Fleckenstein, Peter Zakaria, Sahalia Rashid, Rahul Vyas

Patient Education Projects

No abstract provided.

Conflict With Peer: Scheduling Conflicts, Saleh Al-Juburi, Alexa Kalaj, Amrutha Kotlure, Hannah Lee, Juwan Taylor, Salvatore Serra, Mariam Raheem

Patient Education Projects

No abstract provided.

Conflict With Administrators: Administration Conflicts And Its Impact On Patient Care, Adam Chaban, Ajay Pradhan, Aminah Fayyaz, Cyrus Amirfazli, Karina Haleblian, Nina Brahmbhatt, Amanah Fatima

Patient Education Projects

No abstract provided.

Conflict With Administrators: Addressing Inappropriate Language, Alexander Buendia, Brizzy Brown, Emmanuel Meram, Hasti Nema, Madilyn Mason, Samaah Saifullah, Sahalia Rashid

Patient Education Projects

No abstract provided.

Conflict With Administrators: Administrator Makes An Insensitive Joke, Alexa Bernard, Elli Johnson, Jackson Ferris, Jose Lopez, Susan Hartzell, Theodore Schiff, Amanah Fatima

Patient Education Projects

No abstract provided.

Conflict With Administrators: Administration And Colleague Conflict, Aalia Siddiqui, Anna Zhao, Brian Hughes, Neeraj Ochaney, Amanah Fatima

Patient Education Projects

No abstract provided.

Conflict With Administrators: Documentation And Administrator Conflict, Arainya Durham, Jacob Hall, James Soetedjo, Khush Hussain, Samantha Markowitz, Shruthi Ilango, Amanah Fatima, Fadi Kathawa

Patient Education Projects

No abstract provided.

Conflict With Administrators: Addressing Inappropriate Dress Code, Eve Sherbin, Brock Bradley, Jeremy Taigman, Nathan Li, Pranally Desai, Tiffany Mckenney, Ayman Salem

Patient Education Projects

No abstract provided.

Conflict With Administrators: Communication Professionalism Conflict, Cyra Kharas, Mihika Sridhar, Paul Villa, Robert Leone, Sophia Gandarillas, Kenan Abou Chaer, Astha Saini

Patient Education Projects

No abstract provided.

Conflict With Administrators: Adjustment Of Patient Schedule, Breanna Ramsey, Michelle Chung, Nevil Khurana, Olivia Decker, Riley Wistrom, Sinyu Yang, Wassim Mohamad-Said

Patient Education Projects

No abstract provided.

Conflict With Patient: Medication Noncompliance: Openness And Empathy, Anastasia Goldbaum, Austin Kim, Cole Sabinash, Gabrielle Cowen, Kassim Salami, Simran Brar, Sahalia Rashid

Patient Education Projects

No abstract provided.

Conflict With Patient: Managing Different Expectations Between Physician And Patient, Adam Chaban, Ajay Pradhan, Aminah Fayyaz, Cyrus Amirfazli, Karina Haleblian, Nina Brahmbhatt, Amanah Fatima

Patient Education Projects

No abstract provided.

Conflict With Patient: Empathy And Patient Care, Anjani Raja, Armaan Naghdi, Blaise Deschamps, Jack Mao, Noor Sulieman, Stephanie Barna, Amanah Fatima

Patient Education Projects

No abstract provided.

Conflict With Patient: Long Wait Time At Doctor Office, Alexander Minos, Carline Dugue, Ethan Mathew, Katherine Sommers, Lauren Fleckenstein, Peter Zakaria, Sahalia Rashid, Rahul Vyas

Patient Education Projects

No abstract provided.

Conflict With Patient: Bias And Patient Care, James Burtka, Alyssa Rogers, Kaitlin Verkuilen, Maria Tjilos, Nelson Pinto, Siddharth Tirumala, Amanah Fatima, Fadi Kathawa

Patient Education Projects

No abstract provided.

Conflict With Patient: Patient Frustration With Wait Time, Saleh Al-Juburi, Alexa Kalaj, Amrutha Kotlure, Hannah Lee, Juwan Taylor, Salvatore Serra, Mariam Raheem

Patient Education Projects

No abstract provided.

Conflict With Peer: Multiple Late Arrivals, Anastasia Goldbaum, Austin Kim, Cole Sabinash, Gabrielle Cowen, Kassim Salami, Simran Brar, Sahalia Rashid

Patient Education Projects

No abstract provided.

Conflict With Peer: Unexcused Co-Absence Of Resident, Adam Chaban, Ajay Pradhan, Aminah Fayyaz, Cyrus Amirfazli, Karina Haleblian, Nina Brahmbhatt, Amanah Fatima

Patient Education Projects

No abstract provided.

Conflict With Peer: Team Workload, Anisha Patel, Annelise Gordon, Jonathan Toma, Maximilian Wehner, Rohit Goru, Amanah Fatima

Patient Education Projects

No abstract provided.