Medicine and Health Sciences Commons^™

Risk Of Chronic Health Conditions In Lesbian, Gay, And Bisexual Survivors Of Adolescent And Young Adult Cancers, Amy M Berkman, Eunju Choi, Christabel K Cheung, John M Salsman, Susan K Peterson, Clark R Andersen, Qian Lu, J Andrew Livingston, Michelle A T Hildebrandt, Susan K Parsons, Michael E Roth

Faculty, Staff and Student Publications

BACKGROUND: In the general population, individuals with minoritized sexual orientation and gender identity have a higher burden of chronic health conditions than heterosexual individuals. However, the extent to which sexual orientation is associated with excess burden of chronic conditions in adolescent and young adult cancer survivors (AYACS) is unknown.

METHODS: Lesbian, gay, and bisexual (LGB) AYACSs, LGB individuals without a history of cancer, and heterosexual AYACSs were identified by self-reported data from the cross-sectional National Health Interview Survey (2013-2020). Socioeconomic factors and the prevalence of chronic health conditions were compared between groups using χ

RESULTS: One hundred seventy LGB cancer …

Can Mirna Be The Missing Link Between Parkinson’S Disease And Pesticides?, Fatma Gobba

Theses and Dissertations

Parkinson’s disease (PD) is a common neurodegenerative condition that leads to significant morbidity and a decline in the quality of life. It develops as a consequence of the loss of dopaminergic neurons in the substantia nigra pars compacta. Nevertheless, the development of PD is influenced by environmental factors, and the intricate nature of these relationships is further complicated by a multitude of factors, including the genetic backgrounds that are specific to populations and variations in environmental exposures, such as pesticides. Pesticides, consisting of a diverse family of chemicals commonly used in both agricultural and household settings to protect crops against …

Acute Neutrophilic Vasculitis (Leukocytoclasia) In 36 Covid-19 Autopsy Brains, Roy H. Rhodes, Gordon L. Love, Fernanda Da Silva Lameira, Maryam Sadough Shahmirzadi, Sharon E. Fox, Richard S. Vander Heide

School of Medicine Faculty Publications

Background: Hypercytokinemia, the renin-angiotensin system, hypoxia, immune dysregulation, and vasculopathy with evidence of immune-related damage are implicated in brain morbidity in COVID-19 along with a wide variety of genomic and environmental influences. There is relatively little evidence of direct SARS-CoV-2 brain infection in COVID-19 patients. Methods: Brain histopathology of 36 consecutive autopsies of patients who were RT-PCR positive for SARS-CoV-2 was studied along with findings from contemporary and pre-pandemic historical control groups. Immunostaining for serum and blood cell proteins and for complement components was employed. Microcirculatory wall complement deposition in the COVID-19 cohort was compared to historical control cases. Comparisons …

Phenolic Acids Prevent Sex-Steroid Deficiency-Induced Bone Loss And Bone Marrow Adipogenesis In Mice, Perry C. Caviness, Oxana P. Lazarenko, Michael L. Blackburn, Jennifer F. Chen, Christopher E. Randolph, Jovanny Zabaleta, Fenghuang Zhan, Jin Ran Chen

School of Medicine Faculty Publications

Phenolic acids, such as hippuric acid (HA) and 3-(3-hydroxyphenyl) propionic acid (3-3-PPA), can be produced from microbiome digestion of polyphenols. Previously it was found that HA and 3-3-PPA facilitate bone formation and suppress bone resorption. However, the mechanism of action by which HA and 3-3-PPA protect bone from degeneration is currently unknown. In this report, we present that HA and 3-3-PPA suppression of bone resorption is able to ameliorate bone loss in an ovariectomy (OVX) osteopenic mouse model though not to the extent of Zoledronic acid (ZA). HA and 3-3-PPA treatments were shown to significantly decrease bone marrow adipocyte-like cell …

Aloe Vera Assisted Green Synthesis Of Ag And Cu Co-Doped Zno Nanoparticles And A Comprehensive Analysis Of Their Structural, Morphological, Optical, Electrical And Antibacterial Properties, Md Hasnat Rashid, Saiful Islam Sujoy, Md Saifur Rahman, Md Jahidul Haque

Faculty, Staff and Student Publications

This study investigates the potential of utilizing Aloe vera-assisted green synthesis with transition metal dopants of Ag and Cu for greater efficiency and sustainability in advanced scientific applications utilizing ZnO nanoparticles. Samples were prepared using the co-precipitation method, maintaining a basic pH media of 10. Aloe vera gel extract was chosen for its acclaimed role as a stabilizing and reducing agent and its proven antioxidant, antibacterial, and anticancer properties. The XRD report revealed the hexagonal Wurtzite crystal structure of nanoparticles, exhibiting a crystallite size range of 17-23 nm with substantial alterations in lattice parameters, dislocation density, and bond lengths when …

The Lived Experiences Of Urhobo Women From The Niger Delta Region Of Nigeria During The Menopausal Transition, Omemiyere Sheila Uwayzor

Walden Dissertations and Doctoral Studies

This qualitative phenomenological study offered an in-depth exploration of the menopausal experiences of seven Urhobo women, ages 45–65 years old, representing diverse occupational backgrounds and communities from the Niger Delta region of Nigeria, who shed light on the multifaceted dimensions of menopausal experiences. Grounded in the Meleis transitions theory, the research presented thematic insights from semi-structured interviews, capturing the participants’ physiological, emotional, cultural, and healthcare-related experiences. Interviews were conducted with seven Urhobo women aged between 45 and 65 years old. These menopausal women responded to the research question regarding their lived experiences of Urhobo women during the menopausal transition. Using …

Small Airways In Non-Cystic Fibrosis Bronchiectasis, John D Dickinson, Christopher M Evans, Burton F Dickey

Faculty, Staff and Student Publications

No abstract provided.

A Mutation In F-Actin Polymerization Factor Suppresses The Distal Arthrogryposis Type 5 Piezo2 Pathogenic Variant In Caenorhabditis Elegans, Xiaofei Bai, Harold E Smith, Luis O Romero, Briar Bell, Valeria Vásquez, Andy Golden

Faculty, Staff and Student Publications

The mechanosensitive PIEZO channel family has been linked to over 26 disorders and diseases. Although progress has been made in understanding these channels at the structural and functional levels, the underlying mechanisms of PIEZO-associated diseases remain elusive. In this study, we engineered four PIEZO-based disease models using CRISPR/Cas9 gene editing. We performed an unbiased chemical mutagen-based genetic suppressor screen to identify putative suppressors of a conserved gain-of-function variant pezo-1[R2405P] that in human PIEZO2 causes distal arthrogryposis type 5 (DA5; p. R2718P). Electrophysiological analyses indicate that pezo-1(R2405P) is a gain-of-function allele. Using genomic mapping and whole-genome sequencing approaches, we identified a …

Effect Of Multiple Quantum Well Periods On Structural Properties And Performance Of Extended Short-Wavelength Infrared Leds, Phuc Dinh Nguyen, Minkyeong Kim, Yeongho Kim, Jiyeon Jeon, Suho Park, Chang Soo Kim, Quang Liem Nguyen, Byong Sun Chun, Sang Jun Lee

Faculty, Staff and Student Publications

We present research on the role of multiple quantum well periods in extended short-wavelength infrared InGaAs/InAsPSb type-I LEDs. The fabricated LEDs consisted of 6, 15, and 30 quantum well periods, and we evaluated the structural properties and device performance through a combination of theoretical simulations and experimental characterization. The strain and energy band offset was precisely controlled by carefully adjusting the composition of the InAsPSb quaternary material, achieving high valence and conduction band offsets of 350 meV and 94 meV, respectively. Our LEDs demonstrated a high degree of relaxation of 94-96 %. Additionally, we discovered that the temperature-dependent dark current …

Slc25a39 Links Mitochondrial Gsh Sensing With Iron Metabolism, Xiong Chen, Boyi Gan

Faculty, Staff and Student Publications

Two recent studies by Liu et al.1 in Science and Shi et al.2 in this issue of Molecular Cell identify a mitochondrial GSH-sensing mechanism that couples SLC25A39-mediated GSH import to iron metabolism, advancing our understanding of nutrient sensing within organelles.

Child Health Nurses’ Perceptions Of The Family Community-Based Assistance Resourcing And Education Program In Contemporary Practice: A Qualitative Study, Nicole Latham, Jeanine Young, Josephine Wilson, Michelle Gray, Kendall George

Research outputs 2022 to 2026

Background. The Family Community-based Assistance Resourcing and Education Program (FCP) is a nurse home visiting program that was introduced in Queensland two decades ago to redress health inequalities for infants from families experiencing specific social stressors. Locally adapted versions of this home visiting program are still in use, but have not been evaluated. This study examined child health nurse perceptions of the adapted FCP in one regional Queensland health service. Methods. A qualitative descriptive exploratory study using two focus groups (conducted May 2019) with Child Health Nurses who delivered the FCP was conducted. Transcripts of digital recordings were analysed using …

International Consensus Statement On The Radiological Evaluation Of Dysraphic Malformations Of The Spine And Spinal Cord, Ankit Balani, Jai Sidpra, Sniya Sudhakar, Asthik Biswas, Özgür Öztekin, Valeria Capra, Martin Catala, Andrew J Copp, Neetu Kumar, Navroop Johal, M Zubair Tahir, Dominic Thompson, Dachling Pang, David M Mirsky, Mai-Lan Ho, Thierry A G M Huisman, Andrea Rossi, Kshitij Mankad

Children’s Nutrition Research Center Staff Publications

Dysraphic malformations of the spine and spinal cord (DMSSC) represent a spectrum of common congenital anomalies typically (though not exclusively) affecting the lower spinal segments. These may be responsible for varying degrees of neurologic, orthopedic, and urologic morbidity. With advances in neuroimaging, it is now possible to better diagnose and evaluate these disorders both prenatally and postnatally. Neuroimaging, performed at the right time and with technique optimization, is integral in guiding clinical management. However, the terminology used to describe these lesions has become increasingly confusing, and there is a lack of consensus regarding the essential radiologic features and their clinical …

Pulmonary Fibrosis Stakeholder Summit: A Joint Nhlbi, Three Lakes Foundation, And Pulmonary Fibrosis Foundation Workshop Report, Sydney B Montesi, Christian R Gomez, Michael Beers, Robert Brown, Ishanu Chattopadhyay, Kevin R Flaherty, Christine Kim Garcia, Brigitte Gomperts, Lida P Hariri, Cory M Hogaboam, R Gisli Jenkins, Naftali Kaminski, Grace Hyun J Kim, Melanie Königshoff, Martin Kolb, Darrell N Kotton, Jonathan A Kropski, Joseph Lasky, Chelsea M Magin, Toby M Maher, Mark Mccormick, Bethany B Moore, Cheryl Nickerson-Nutter, Justin Oldham, Anna J Podolanczuk, Ganesh Raghu, Ivan Rosas, Steven M Rowe, William T Schmidt, David Schwartz, Jessica E Shore, Cathie Spino, J Matthew Craig, Fernando J Martinez

Faculty, Staff and Students Publications

Despite progress in elucidation of disease mechanisms, identification of risk factors, biomarker discovery, and the approval of two medications to slow lung function decline in idiopathic pulmonary fibrosis and one medication to slow lung function decline in progressive pulmonary fibrosis, pulmonary fibrosis remains a disease with a high morbidity and mortality. In recognition of the need to catalyze ongoing advances and collaboration in the field of pulmonary fibrosis, the NHLBI, the Three Lakes Foundation, and the Pulmonary Fibrosis Foundation hosted the Pulmonary Fibrosis Stakeholder Summit on November 8–9, 2022. This workshop was held virtually and was organized into three topic …

Guideline Concordance For Timely Chest Imaging After New Presentations Of Dyspnoea Or Haemoptysis In Primary Care: A Retrospective Cohort Study, Minjoung Monica Koo, Luke T A Mounce, Meena Rafiq, Matthew E J Callister, Hardeep Singh, Gary A Abel, Georgios Lyratzopoulos

Faculty, Staff and Students Publications

Background: Guidelines recommend urgent chest X-ray for newly presenting dyspnoea or haemoptysis but there is little evidence about their implementation.

Methods: We analysed linked primary care and hospital imaging data for patients aged 30+ years newly presenting with dyspnoea or haemoptysis in primary care during April 2012 to March 2017. We examined guideline-concordant management, defined as General Practitioner-ordered chest X-ray/CT carried out within 2 weeks of symptomatic presentation, and variation by sociodemographic characteristic and relevant medical history using logistic regression. Additionally, among patients diagnosed with cancer we described time to diagnosis, diagnostic route and stage at diagnosis by guideline-concordant status. …

Developing And Piloting An Online Course On Osteoporosis Using A Multidisciplinary Multi-Institute Approach- A Cross-Sectional Qualitative Study, Lena Jafri, Hafsa Majid, Arsala Jameel Farooqui, Sibtain Ahmed, Muhammad Umer Naeem Effendi, Maseeh Uz Zaman, Qamar` Riaz, Noreen Nasir, Syeda Sadia Fatima, Sarah Nadeem, Rizwan Haroon Rashid, Aysha Habib

Department of Pathology and Laboratory Medicine

Introduction: Postgraduate medical trainees (PGs) in developing nations face various educational hurdles due to limited access to quality resources and training facilities. This study aimed to assess the effectiveness of e-learning, particularly Massive Open Online Courses (MOOCs), within postgraduate medical education. It involved the development of a customized online course focused on osteoporosis for PGs and an examination of their perspectives and preferences concerning online learning methods like Virtual Learning Environment (VLE) platforms.
Methods: The study was conducted from January 2018 to December 2020. A multi-institutional, multidisciplinary team was assembled to design an osteoporosis course on the VLE platform. PGs …

Virtual, Augmented, And Mixed Reality Applications For Surgical Rehearsal, Operative Execution, And Patient Education In Spine Surgery: A Scoping Review, Tim Bui, Miguel A Ruiz-Cardozo, Harsh S Dave, Karma Barot, Michael Ryan Kann, Karan Joseph, Sofia Lopez-Alviar, Gabriel Trevino, Samuel Brehm, Alexander T Yahanda, Camilo A Molina

2020-Current year OA Pubs

No abstract provided.

High Resolution Spatial Profiling Of Kidney Injury And Repair Using Rna Hybridization-Based In Situ Sequencing, Haojia Wu, Eryn E Dixon, Qiao Xuanyuan, Juanru Guo, Yasuhiro Yoshimura, Chitnis Debashish, Anezka Niesnerova, Hao Xu, Morgane Rouault, Benjamin D Humphreys

2020-Current year OA Pubs

Emerging spatially resolved transcriptomics technologies allow for the measurement of gene expression in situ at cellular resolution. We apply direct RNA hybridization-based in situ sequencing (dRNA HybISS, Cartana part of 10xGenomics) to compare male and female healthy mouse kidneys and the male kidney injury and repair timecourse. A pre-selected panel of 200 genes is used to identify cell state dynamics patterns during injury and repair. We develop a new computational pipeline, CellScopes, for the rapid analysis, multi-omic integration and visualization of spatially resolved transcriptomic datasets. The resulting dataset allows us to resolve 13 kidney cell types within distinct kidney niches, …

Influence Of Intraradicular Restoration Technique On The Biomechanical Behavior Of Upper Canines, Ana Paula Gomes

Annual Research Symposium

This study assessed the stress distribution in endodontically treated upper canines subjected to the cementation of two types of intraradicular retainers.

Detection Of Cervical Lymph Node Micrometastasis - A Machine Learning Based Approach, Dr. Sowmya Sv, Dominic Augustine, Kuntala Mondal

Annual Research Symposium

No abstract provided.

Influence Of Abutments Surface (Machined Vs. Laser-Microgrooved) In Soft-Tissue Response During One Year Of Function: Clinical And Biochemical Outcomes Of A Rct With Split-Mouth Design, Elisa Maccari

Annual Research Symposium

To evaluate peri-implant soft tissue behaviour around machined vs laser-microgrooved implants/healing/prosthetic abutments during 1 year of function by assessing IL-6, IL-1b and MMP-8 levels in peri-implant crevicular fluid (PICF).

Clinical Success Of Restorations With Bioactive And Non-Bioactive Materials: Systematic Review And Network Meta-Analysis, Juliana Benace Fernandes, Sheila Mondragón Contreras, Eduardo Bresciani, Taciana Marco Ferraz Caneppele

Annual Research Symposium

The oral cavity is a complex and dynamic environment with frequent pH and temperature changes that can affect the longevity of dental restorations. Consequently, bioactive restorative materials, capable of advantageous interactions with the oral environment and dental tissues, are promising alternatives. However, there is limited scientific evidence of their clinical performance. Therefore, we conducted this systematic review and network meta-analysis of clinical studies to address the research question: Does the clinical evaluation of restorations on permanent teeth with bioactive materials show greater success rates than those with non-bioactive materials?

Matlab Based Phenotypic Evaluation And Gene Expression Of Cd44 And Cd133 Biomarkers In The Prediction Of Oral Squamous Cell Carcinoma Metastasis, Dr. Sowmya Sv

Annual Research Symposium

Oral cancer accounts to 20–30% of all cancers in India. The major difficulty in managing carcinomas is due to failure in the control and detection of metastases (>90% deaths). Cancer stem cells (CSCs) are tumor-initiating cells that survive even after extensive radiotherapy and chemotherapy. Recently, the use of computer-assisted quantification methods employing image processing is drawing attention wherein information can be automatically extracted from the immunostained digitized images. The aim of the study was to assess the metastatic risk of Oral Squamous Cell Carcinoma (OSCC) by the phenotypic evaluation and gene expression of CD44 and CD133 biomarkers with clinical …

Determination Of The Correlation Between Age And Gender With Canine Index, Intermolar Width And Palatal Rugae Patterns, Dr. Sowmya Sv, Dominic Augustine

Annual Research Symposium

Dental records are of paramount importance in human identification considering the distinct traits of every individual. Although DNA and finger print analysis are techniques employed for faster and secure identification, in mass disasters, odontometric analysis can play a vital role in identification. Studies in the past have used parameters like arch perimeters, lip prints and palatal rugae pattern to determine age and gender of an individual. However, these studies correlated one parameter at a time and concluded that there was no significant correlation of the parameters to age and gender. The present study aimed to assess the canine index, intermolar …

Efficacy Of Bone Marrow Aspirates In Bone Regeneration Compared To Conventional Bone Grafts- A Systematic Review, Hannah Kadic, Shilpa Bhandi, Kamran H. Awan, Frank Licari, Shankargouda Patil

Annual Research Symposium

The search for a superior bone graft substitute compared to the gold standard of harvesting autogenous bone grafts has plagued dentists for decades. With the advent of tissue engineering, the search has been aimed at bone graft substitutes with osteogenic potential, in addition to the osteoinductive and osteoconductive properties. Bone Marrow Aspirates (BMAs) has evolved as a potential adjunct to conventional bone grafts that can substantially enhance the bone regeneration potential of these materials. The present systematic review aims to explore and assess the literature on the efficacy of bone marrow aspirates in new bone formation.

Silver Nano Particle Or Sodium Hypochlorite A Better Denture Cleanser, Dr.Tessa Kuriachan, Dr.Rahul Senan, Dr. Parvathy B, Dr. Keerthi Pt

Annual Research Symposium

Denture hygiene is compromised both due to the limitations of the denture base material as well as the lack of manual dexterity of denture wearers. Moreover, the rough tissue surface of the dentures affect the initial formation of candidal biofilms probably because it provides a greater surface area and protected sites for colonization. Among the various methods available to disinfect dentures, chemical method using Sodium hypochlorite seems to be the most effective one. Even though sodium hypochlorite is an effective denture cleanser,it has many disadvantages like the increased roughness of the denture surface and decreased colour stability. So a better …

Association Of Sleep Quality With Academic Performance Among Undergraduate Dental Students, Kamyar Bagheri, Shilpa Bhandi, Kamran Awan, Frank Licari, Shankargouda Patil

Annual Research Symposium

This systematic review aimed to assess the association between sleep quality and academic performance among undergraduate dental students.

Methods: Electronic databases of Scopus, Embase, Medline, and Web of Science were searched for relevant papers published in the English language in May 2023.Study selection, data extraction and quality assessment were performed in duplicate with JBI Institute’s Critical Appraisal Checklist used to quality assessment. GRADEwas used to assess certainty of evidence.

Mechanical Behavior Of Premolars With Incomplete Rhizogenesis After Apexification And Revascularization A Finite Element Study, Camila Barbosa, Fernando Faria-Júnior, Gustavo Guerrero, Ana Carolina Silva, Alexandre Borges, Marcia Valera

Annual Research Symposium

The aim of this study was to evaluate the mechanical resistance of premolars with incomplete rhizogenesis using the FEA methodology, comparing apexification methods and regenerative endodontic procedures.

Confidence Of Clark County Medical Students In Identifying Dermatologic Conditions On Different Fitzpatrick Skin Types, Ramaditya Srinivasmurthy

Annual Research Symposium

Racial health disparities are apparent in the field of dermatology across the United States. Certain dermatologic conditions are more likely to go undiagnosed in people with skin of color (SOC), leading to increased morbidity/mortality. Underrepresentation of darker skin tones in medical education may be a contributing factor. This study explores the ability and confidence of TUNCOM students to recognize dermatological conditions on various skin tones.

A 23 question survey was given to 173 second year students to examine their ability and confidence in identifying dermatologic conditions on non-SOC (Fitzpatrick I-III) and SOC (Fitzpatrick IV-VI). Images of common skin disorders on …

Convolutional Neural Network Based Analysis - An Aid To Diagnose Bacterial And Fungal Osteomyelitis, Saiprasad Alva, Dominic Augustine, Sowmya Sv, Mukul Saini, Sanjana Shetty

Annual Research Symposium

Osteomyelitis may be classified as Bacterial (Actinomycotic), Fungal (Mucormycotic), or combined based on the etiological agent. During histopathological examination, there is a high chance that bacterial colonies or fungal hyphae may be missed by the human eye, especially when there is a paucity of organisms. This may lead to a faulty diagnosis of the type of osteomyelitis which along with an improper treatment plan would cause further progression of the disease and various other complications. Therefore, the diagnosis of the exact etiological variant of osteomyelitis is of prime importance to design an appropriate treatment plan. In the present study, bone …

Influence Of Sleep Pattern And Oral Hydration On Academic Performance Among Undergraduate Dental Students-A Pilot Study, Bassam Alibrahim

Annual Research Symposium

Sound sleep is important for preserving good physical, mental, and emotional health. An association with learning skills, critical decision making and thinking is also observed [1]. Poor hydration is associated with several health outcomes including poor oral health and academic performance. Timely assessment of oral hydration of students holds a potential to improve their oral health and academic performance [1, 2]. This study is designed to investigate the influence of oral hydration status and sleep deprivation on academic achievements of dental college undergraduates