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2024

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Articles 19231 - 19260 of 27225

Full-Text Articles in Medicine and Health Sciences

Social Needs Risk And Patient Outcomes With Supportive Oncology Care, Rebecca Cammy, Lcsw, Joshua Banks, Ma Feb 2024

Social Needs Risk And Patient Outcomes With Supportive Oncology Care, Rebecca Cammy, Lcsw, Joshua Banks, Ma

Department of Medical Oncology Posters

Objective

This study utilized social risk data in the electronic heath record collected in routine clinical practice and examined relationships with supportive oncology care contacts and patient outcomes.


Repurposing Of Us-Fda-Approved Drugs As Negative Modulators Of Ubiquitin Specific Protease-7 (Usp7), Seema Zadi, Sumaira Javaid, Atia-Tul-Wahab, Humaira Zafar, Muhammad Awais, Innokentiy Maslennikov, M. Iqbal Choudhary Feb 2024

Repurposing Of Us-Fda-Approved Drugs As Negative Modulators Of Ubiquitin Specific Protease-7 (Usp7), Seema Zadi, Sumaira Javaid, Atia-Tul-Wahab, Humaira Zafar, Muhammad Awais, Innokentiy Maslennikov, M. Iqbal Choudhary

Pharmacy Faculty Articles and Research

Ubiquitin-specific protease7 (USP7) regulates the stability of the p53 tumor suppressor protein and several other proteins critical for tumor cell survival. Aberrant expression of USP7 facilitates human malignancies by altering the activity of proto-oncogenes/proteins, and tumor suppressor genes. Therefore, USP7 is a validated anti-cancer drug target. In this study, a drug repurposing approach was used to identify new hits against the USP7 enzyme. It is one of the most strategic approaches to find new uses for drugs in a cost- and time-effective way. Nuclear Magnetic Resonance-based screening of 172 drugs identified 11 compounds that bind to the catalytic domain of …


Empowering Faculty To Incorporate Large Language Models In Nursing Education Using A Delegation Framework, Jason Blomquist, Sarah Llewellyn, Jenny Alderden, Kelley Connor Feb 2024

Empowering Faculty To Incorporate Large Language Models In Nursing Education Using A Delegation Framework, Jason Blomquist, Sarah Llewellyn, Jenny Alderden, Kelley Connor

Nursing Faculty Publications and Presentations

Large language models (LLMs) can support nursing education but pose questions of validity, reliability, and ethical use. This article proposes using the five rights of nursing delegation framework by the National Council of State Boards of Nursing to teach nursing students about the appropriate use of LLMs in health care and nursing education. Nursing faculty can teach students how to assess the validity and reliability of the information provided by LLMs, document its use, and reference and cite information appropriately.


Combination Radiofrequency Ablation And Vertebral Cement Augmentation For Spinal Metastatic Tumors: A Systematic Review And Meta-Analysis Of Safety And Treatment Outcomes, Andrew Chen, Navraj Sagoo, Christopher Vannabouathong, Yashas Reddy, Sathvik Deme, Sahiti Patibandla, Peter Passias, Shaleen Vira Feb 2024

Combination Radiofrequency Ablation And Vertebral Cement Augmentation For Spinal Metastatic Tumors: A Systematic Review And Meta-Analysis Of Safety And Treatment Outcomes, Andrew Chen, Navraj Sagoo, Christopher Vannabouathong, Yashas Reddy, Sathvik Deme, Sahiti Patibandla, Peter Passias, Shaleen Vira

SKMC Student Presentations and Publications

BACKGROUND: The treatment of spine metastases continues to pose a significant clinical challenge, requiring the integration of multiple therapeutic modalities to address the multifactorial aspects of this disease process. Radiofrequency ablation (RFA) and vertebral cement augmentation (VCA) are 2 less invasive modalities compared to open surgery that have emerged as promising strategies, offering the potential for both pain relief and preservation of vertebral stability. The utility of these approaches, however, remains uncertain and subject to ongoing investigation.This systematic review and meta-analysis evaluates the available evidence and synthesize the results of studies that have investigated the combination of RFA and VCA …


The Hip Spine Relationship—What We Know And What We Don’T: A Narrative Review, Michael Mccurdy, Yunsoo Lee, Gino Dinicola, Albert Ku, Alex R. Vaccaro, Alan S. Hilibrand, Gregory D. Schroeder, Christopher K. Kepler, Mark J. Lambrechts Feb 2024

The Hip Spine Relationship—What We Know And What We Don’T: A Narrative Review, Michael Mccurdy, Yunsoo Lee, Gino Dinicola, Albert Ku, Alex R. Vaccaro, Alan S. Hilibrand, Gregory D. Schroeder, Christopher K. Kepler, Mark J. Lambrechts

Rothman Institute Papers

Background and Objective: The hip-spine syndrome was first described in 1983. The premise of the report was that the hip and spine are closely related and patients can easily have overlapping conditions and misdiagnoses. Since that time, there has been considerable advancement in our understanding of spinopelvic parameters and how degenerative disc disease can affect the pelvis and subsequently the acetabulum. Our objective is to provide an updated review on the relationship between hip and spine degeneration, how we define the relationship, and what steps should be taken when planning surgical intervention for these patients.

Methods: A literature review was …


Mirizzi Syndrome: The Trojan Horse Of Gallbladder Disease, Mary Froehlich, Elizabeth M. Sodomin, Taylor Fontenot, Noama Iftekhar, Christian N. Chan Feb 2024

Mirizzi Syndrome: The Trojan Horse Of Gallbladder Disease, Mary Froehlich, Elizabeth M. Sodomin, Taylor Fontenot, Noama Iftekhar, Christian N. Chan

Department of Surgery Faculty Research

Background: The incidence of Mirizzi Syndrome ranges from 0.05 to 5.7 % of patients who undergo cholecystectomy. The purpose of this study is to examine the preoperative workup and postoperative outcomes for patients diagnosed with Mirizzi Syndrome. Methods: Retrospective chart review was conducted between January 2018 and January 2022 at a single institution. All adult patients who underwent cholecystectomy were included. Results: 1628 patients underwent cholecystectomy of which 47 were diagnosed with Mirizzi Syndrome. The majority of patients had type 1 Mirizzi Syndrome. Preoperative studies were often nondiagnostic and 81 % of cases were diagnosed intraoperatively. 66 % of cases …


Analisis Kelengkapan Resume Medis Dan Ketepatan Koding Layanan Operasi Kanker Payudara Di Rumah Sakit Kanker Dharmais Tahun 2022, Yudi Febriadi, Atik Nurwahyuni Feb 2024

Analisis Kelengkapan Resume Medis Dan Ketepatan Koding Layanan Operasi Kanker Payudara Di Rumah Sakit Kanker Dharmais Tahun 2022, Yudi Febriadi, Atik Nurwahyuni

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

The background to this research is that there are still National Health Insurance (JKN) claim files being returned to the Dharmais Cancer Hospital (RSKD) with the most common causes being cases of coding confirmation and medical resumes. RSKD started using electronic medical records (eMR) in 2020. In 2018 research with a sample of 45 medical records, it was found that 2.2% of patients were incomplete in filling out the patient identity column, 91.1% of indications for admission, 44.4% of physical examinations and supporting examinations. 8.9%. In addition, it was found that 17.8% of the main diagnosis coding was inappropriate. In …


The Influence Of Motivation And Knowledge On The Completeness Of Medical Records With Attitude As An Intervening Factor, Junaedi Junaedi, Supriyantoro Supriyantoro, Intan Silviana Mustikawati, Ericko Ongko Joyo Feb 2024

The Influence Of Motivation And Knowledge On The Completeness Of Medical Records With Attitude As An Intervening Factor, Junaedi Junaedi, Supriyantoro Supriyantoro, Intan Silviana Mustikawati, Ericko Ongko Joyo

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

Incomplete medical record filling by doctors is still a widespread problem encountered in various hospitals. Incomplete medical record documentation is very detrimental to the hospital. This research aims to determine the correlation between motivation and workload on doctors' completeness of medical record filling through attitude mediation. This study was conducted with a cross-sectional design, which included 40 doctors who worked at the inpatient ward of Annisa Citeureup Hospital as the respondents. Motivation, knowledge, and attitudes were assessed using a questionnaire with a Likert scale, while the medical records completeness data was obtained by directly evaluating the medical records. Partial least …


Analisis Produk Layanan Rs Apung Nusa Waluya 2 Menurut Cara Bauran Pemasaran, Ivan Reynaldo Lubis, Hilda Melissa, Indah Pratiwi Suwandi, Irfan Rohot Uli Manik, Wahyu Sulistiadi Feb 2024

Analisis Produk Layanan Rs Apung Nusa Waluya 2 Menurut Cara Bauran Pemasaran, Ivan Reynaldo Lubis, Hilda Melissa, Indah Pratiwi Suwandi, Irfan Rohot Uli Manik, Wahyu Sulistiadi

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

Hospitals as health service institutions are essential for society. However, in Indonesia, hospitals are not always available in areas far from regional or city government centers. Floating hospitals are an alternative that plays a significant role in island countries such as Indonesia. Even though the number of floating hospitals is very limited, marketing strategies through a marketing mix are still needed for their development, whether assessed from a business or non-business perspective. This study used a descriptive-analytical approach by collecting data from observations and collecting literature as the discussion material. As a result of simple observations and analysis, this study …


Real-World Effectiveness Of Add-Onfremanezumab In Patients Receiving Onabotulinumtoxina For The Prevention Of Chronic Migraine In A Us Tertiary Headache Center: A Retrospective Chart Review Study, Hsiangkuo Yuan, Fred Cohen, Maurice T. Driessen, Lynda J. Krasenbaum, Mario Ortega, Mary Hopkins, Michael J. Marmura Feb 2024

Real-World Effectiveness Of Add-Onfremanezumab In Patients Receiving Onabotulinumtoxina For The Prevention Of Chronic Migraine In A Us Tertiary Headache Center: A Retrospective Chart Review Study, Hsiangkuo Yuan, Fred Cohen, Maurice T. Driessen, Lynda J. Krasenbaum, Mario Ortega, Mary Hopkins, Michael J. Marmura

Department of Jefferson Headache Center Papers and Presentations

Background: Concomitant fremanezumab, a calcitonin gene-related peptide (CGRP) pathway monoclonal antibody (mAb), and onabotulinumtoxinA (onabotA) improve treatment response compared with onabotA alone in patients with chronic migraine (CM). Methods: This was a single-center, retrospective, observational study that assessed treatment response (change over time in monthly headache days [MHD] and pain intensity [PI]) in adult patients with CM receiving fremanezumab as add-on therapy to onabotA for CM prevention. Results: In the study population (N = 116, age 50.0 ± 13.1, female 85.3%, pre-index onabotA use 46.5 ± 34.2 months) receiving concurrent onabotA and fremanezumab for 17.5 ± 11.6 months, MHD decreased …


Endoscopic Hyperspectral Imaging System To Discriminate Tissue Characteristics In Tissue Phantom And Orthotopic Mouse Pancreatic Tumor Model, Na Eun Mun, Thi Kim Chi Tran, Dong Hui Park, Jin Hee Im, Jae Il Park, Thanh Dat Le, Young Jin Moon, Seong-Young Kwon, Su Woong Yoo Feb 2024

Endoscopic Hyperspectral Imaging System To Discriminate Tissue Characteristics In Tissue Phantom And Orthotopic Mouse Pancreatic Tumor Model, Na Eun Mun, Thi Kim Chi Tran, Dong Hui Park, Jin Hee Im, Jae Il Park, Thanh Dat Le, Young Jin Moon, Seong-Young Kwon, Su Woong Yoo

Faculty, Staff and Student Publications

In this study, we developed an endoscopic hyperspectral imaging (eHSI) system and evaluated its performance in analyzing tissues within tissue phantoms and orthotopic mouse pancreatic tumor models. Our custom-built eHSI system incorporated a liquid crystal tunable filter. To assess its tissue discrimination capabilities, we acquired images of tissue phantoms, distinguishing between fat and muscle regions. The system underwent supervised training using labeled samples, and this classification model was then applied to other tissue phantom images for evaluation. In the tissue phantom experiment, the eHSI effectively differentiated muscle from fat and background tissues. The precision scores regarding fat tissue classification were …


Evaluation Of Enamel Volume Loss After Exposure To Energy Drinks, Karen A. Schulze, Noëlle M. Santucci, Bina Surti, Stefan Habelitz, Mouchumi Bhattacharyya, Warden Noble Feb 2024

Evaluation Of Enamel Volume Loss After Exposure To Energy Drinks, Karen A. Schulze, Noëlle M. Santucci, Bina Surti, Stefan Habelitz, Mouchumi Bhattacharyya, Warden Noble

Pacific Faculty Work

Objectives: This study was conducted to determine the erosive potential of various commercial energy drinks (EDs), sports drinks (SDs), and sugar sweetened beverages (SSBs) and to correlate quantitative changes in tooth enamel volume loss based on the pH and titratable acidity of the drinks. Methods: A flat plane on the facial surface of 36 human incisor teeth was created and embedded in sample holders using resin. After pre-scanning with a profilometer (Proscan 2000, Scantron, Ind Products Ltd., Taunton, UK), the six samples per group were immersed for 4 h into either Monster Energy™ (ED), Rockstar™ (ED), Red Bull™ (ED), or …


Clonal Gene Signatures Predict Prognosis In Mesothelioma And Lung Adenocarcinoma, Yupei Lin, Bryan M Burt, Hyun-Sung Lee, Thinh T Nguyen, Hee-Jin Jang, Claire Lee, Wei Hong, Robert Taylor Ripley, Christopher I Amos, Chao Cheng Feb 2024

Clonal Gene Signatures Predict Prognosis In Mesothelioma And Lung Adenocarcinoma, Yupei Lin, Bryan M Burt, Hyun-Sung Lee, Thinh T Nguyen, Hee-Jin Jang, Claire Lee, Wei Hong, Robert Taylor Ripley, Christopher I Amos, Chao Cheng

Faculty, Staff and Students Publications

Malignant pleural mesothelioma (MPM) is a rare but lethal pleural cancer with high intratumor heterogeneity (ITH). A recent study in lung adenocarcinoma has developed a clonal gene signature (ORACLE) from multiregional transcriptomic data and demonstrated high prognostic values and reproducibility. However, such a strategy has not been tested in other types of cancer with high ITH. We aimed to identify biomarkers from multi-regional data to prognostically stratify MPM patients. We generated a multiregional RNA-seq dataset for 78 tumor samples obtained from 26 MPM patients, each with one sample collected from a superior, lateral, and inferior region of the tumor. By …


In-Hospital Mortality Trends After Surgery For Traumatic Thoracolumbar Injury: A National Inpatient Sample Database Study, Michael Mccurdy, Rajkishen Narayanan, Omar Tarawneh, Yunsoo Lee, Matthew Sherman, Teeto Ezeonu, Michael Carter, Jose A. Canseco, Alan S. Hilibrand, Alex R. Vaccaro, Christopher K. Kepler, Gregory D. Schroeder Feb 2024

In-Hospital Mortality Trends After Surgery For Traumatic Thoracolumbar Injury: A National Inpatient Sample Database Study, Michael Mccurdy, Rajkishen Narayanan, Omar Tarawneh, Yunsoo Lee, Matthew Sherman, Teeto Ezeonu, Michael Carter, Jose A. Canseco, Alan S. Hilibrand, Alex R. Vaccaro, Christopher K. Kepler, Gregory D. Schroeder

Department of Orthopaedic Surgery Faculty Papers

INTRODUCTION: Given the increasing incidence of traumatic thoracolumbar injuries in recent years, studies have sought to investigate potential risk factors for outcomes in these patients.

RESEARCH QUESTION: The aim of this study was to investigate trends and risk factors for in-hospital mortality after fusion for traumatic thoracolumbar injury.

MATERIALS AND METHODS: Patients undergoing thoracolumbar fusion after traumatic injury were queried from the National Inpatient Sample (NIS) from 2012 to 2017. Analysis was performed to identify risk factors for inpatient mortality after surgery.

RESULTS: Patients in 2017 were on average older (51.0 vs. 48.5, P = 0.004), had more admitting diagnoses …


Sociodemographic And Clinical Characteristics Of People With Oldest Older Age Bipolar Disorder In A Global Sample: Results From The Global Aging And Geriatric Experiments In Bipolar Disorder Project, Peijun Chen, Martha Sajatovic, Joy Yala, Kaylee Sarna Feb 2024

Sociodemographic And Clinical Characteristics Of People With Oldest Older Age Bipolar Disorder In A Global Sample: Results From The Global Aging And Geriatric Experiments In Bipolar Disorder Project, Peijun Chen, Martha Sajatovic, Joy Yala, Kaylee Sarna

Faculty Scholarship

Objects: Studies of older age bipolar disorder (OABD) have mostly focused on “younger old” individuals. Little is known about the oldest OABD (OOABD) individuals aged ≥70 years old. The Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE-BD) project provides an opportunity to evaluate the OOABD group to understand their characteristics compared to younger groups. Methods: We conducted cross-sectional analyses of the GAGE-BD database, an integrated, harmonized dataset from 19 international studies. We compared the sociodemographic and clinical characteristics of those aged <50 (YABD, n = 184), 50–69 (OABD, n = 881), and ≥70 (OOABD, n = 304). To standardize the comparisons between age categories and all characteristics, we used multinomial logistic regression models with age category as the dependent variable, with each characteristic as the independent variable, and clustering of standard errors to account for the correlation between observations from each of the studies. Results: OOABD and OABD had lower severity of manic symptoms (Mean YMRS = 3.3, 3.8 respectively) than YABD (YMRS = 7.6), and lower depressive symptoms (% of absent = 65.4%, and 59.5% respectively) than YABD (18.3%). OOABD and OABD had higher physical burden than YABD, especially in the cardiovascular domain (prevalence = 65% in OOABD, 41% in OABD and 17% in YABD); OOABD had the highest prevalence (56%) in the musculoskeletal domain (significantly differed from 39% in OABD and 31% in YABD which didn't differ from each other). Overall, OOABD had significant cumulative physical burden in numbers of domains (mean = 4) compared to both OABD (mean = 2) and YABD (mean = 1). OOABD had the lowest rates of suicidal thoughts (10%), which significantly differed from YABD (26%) though didn't differ from OABD (21%). Functional status was higher in both OOABD (GAF = 63) and OABD (GAF = 64), though only OABD had significantly higher function than YABD (GAF = 59). Conclusions: OOABD have unique features, suggesting that (1) OOABD individuals may be easier to manage psychiatrically, but require more attention to comorbid physical conditions; (2) OOABD is a survivor cohort associated with resilience despite high medical burden, warranting both qualitative and quantitative methods to better understand how to advance clinical care and ways to age successfully with BD.


Tau And Aβ42 In Lavage Fluid Of Pneumonia Patients Are Associated With End-Organ Dysfunction: A Prospective Exploratory Study, Phoibe Renema, Jean-Francois Pittet, Angela P. Brandon, Sixto M. Leal Jr, Steven Gu, Grace Promer, Andrew Hackney, Phillip Braswell, Andrew Pickering, Grace Rafield, Sarah Voth, Ron Balczon, Mike T. Lin, K. Adam Morrow, Jessica Bell, Jonathon P. Audia, Diego Alvarez, Troy Stevens, Brant M. Wagener Feb 2024

Tau And Aβ42 In Lavage Fluid Of Pneumonia Patients Are Associated With End-Organ Dysfunction: A Prospective Exploratory Study, Phoibe Renema, Jean-Francois Pittet, Angela P. Brandon, Sixto M. Leal Jr, Steven Gu, Grace Promer, Andrew Hackney, Phillip Braswell, Andrew Pickering, Grace Rafield, Sarah Voth, Ron Balczon, Mike T. Lin, K. Adam Morrow, Jessica Bell, Jonathon P. Audia, Diego Alvarez, Troy Stevens, Brant M. Wagener

University Faculty and Staff Publications

Bacterial pneumonia and sepsis are both common causes of end-organ dysfunction, especially in immunocompromised and critically ill patients. Pre-clinical data demonstrate that bacterial pneumonia and sepsis elicit the production of cytotoxic tau and amyloids from pulmonary endothelial cells, which cause lung and brain injury in naïve animal subjects, independent of the primary infection. The contribution of infection-elicited cytotoxic tau and amyloids to end-organ dysfunction has not been examined in the clinical setting. We hypothesized that cytotoxic tau and amyloids are present in the bronchoalveolar lavage fluid of critically ill patients with bacterial pneumonia and that these tau/amyloids are associated with …


Isothiocyanates Potentiate Tazemetostat-Induced Apoptosis By Modulating The Expression Of Apoptotic Genes, Members Of Polycomb Repressive Complex 2, And Levels Of Tri-Methylating Lysine 27 At Histone 3 In Human Malignant Melanoma Cells, Ioannis Anestopoulos, Ioannis Paraskevaidis, Sotiris Kyriakou, Lambrini E. Giova, Dimitrios T. Trafalis, Sotiris Botaitis, Rodrigo Franco, Aglaia Pappa, Mihalis L. Panayiotidis Feb 2024

Isothiocyanates Potentiate Tazemetostat-Induced Apoptosis By Modulating The Expression Of Apoptotic Genes, Members Of Polycomb Repressive Complex 2, And Levels Of Tri-Methylating Lysine 27 At Histone 3 In Human Malignant Melanoma Cells, Ioannis Anestopoulos, Ioannis Paraskevaidis, Sotiris Kyriakou, Lambrini E. Giova, Dimitrios T. Trafalis, Sotiris Botaitis, Rodrigo Franco, Aglaia Pappa, Mihalis L. Panayiotidis

School of Veterinary and Biomedical Sciences: Faculty Publications

In this study, we utilized an in vitro model consisting of human malignant melanoma as well as non-tumorigenic immortalized keratinocyte cells with the aim of characterizing the therapeutic effectiveness of the clinical epigenetic drug Tazemetostat alone or in combination with various isothiocyanates. In doing so, we assessed markers of cell viability, apoptotic induction, and expression levels of key proteins capable of mediating the therapeutic response. Our data indicated, for the first time, that Tazemetostat caused a significant decrease in viability levels of malignant melanoma cells in a dose- and time-dependent manner via the induction of apoptosis, while non-malignant keratinocytes were …


A Model-Agnostic Computational Method For Discovering Gene–Phenotype Relationships And Inferring Gene Networks Via In Silico Gene Perturbation, Rastko Stojšin, Xiangning Chen, Zhongming Zhao Feb 2024

A Model-Agnostic Computational Method For Discovering Gene–Phenotype Relationships And Inferring Gene Networks Via In Silico Gene Perturbation, Rastko Stojšin, Xiangning Chen, Zhongming Zhao

Faculty, Staff and Student Publications

Background Deep learning architectures have advanced genotype‒phenotype mappings with precision but often obscure the roles of specific genes and their interactions. Our research introduces a model-agnostic computational methodology, capitalizing on the analytical strengths of deep learning models to serve as biological proxies, enabling interpretation of key gene interactions and their impact on phenotypic outcomes. The objective of this research is to refine the understanding of genetic networks in complex traits by leveraging the nuanced decision-making of advanced models.

Results Testing was conducted across several computational models representing varying levels of complexity trained on gene expression datasets for the prediction of …


Efficiency In Hr: Lean Management With E-Sep And Auto Closing System In Pasar Minggu Hospital, Melanie Husna, Prima Syahputra Feb 2024

Efficiency In Hr: Lean Management With E-Sep And Auto Closing System In Pasar Minggu Hospital, Melanie Husna, Prima Syahputra

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

The study focuses on enhancing efficiency in outpatient transactions at Pasar Minggu Hospital, which, in 2019, experienced a high volume of visits primarily covered by national health insurance. With 299,041 outpatient visits using national health insurance that year, the hospital's transition to a COVID-19 referral facility in 2020 underscored the urgency of streamlining operations. Presently, outpatient transactions are manually closed by three staff members, led by the financial administrator, who handles Participant Eligibility Letter files, resolves transaction issues, and finalizes services. Given the imperative for digitization accelerated by the pandemic, the study adopts lean thinking, employing a value stream map …


Pleomorphic Adenoma With A Novel Gene Rearrangement-Linc01606::Plag1, Udit Naik, Sara E Amin, Mahmoud Elsayad, Karan Saluja Feb 2024

Pleomorphic Adenoma With A Novel Gene Rearrangement-Linc01606::Plag1, Udit Naik, Sara E Amin, Mahmoud Elsayad, Karan Saluja

Faculty, Staff and Student Publications

Background: Pleomorphic adenoma is a well-known benign salivary gland neoplasm characterized by the presence of varying proportions of three different components, including bi-layered ducts, myoepithelial cells, and admixed within a chondromyxoid/fibrous stroma.

Method: We report an interesting case of an adult male who presented with bleeding from an extensively degenerated parotid gland mass, concerning for a vascular neoplasm versus primary malignant tumor. Microscopically, majority of the viable tumor exhibited diffuse proliferation of spindle to epithelioid cells, with focal areas depicting cribriform glands, ducts, and scant chondromyxoid stroma.

Result: Next-generation sequencing (NGS) RNA-based fusion panel analysis identified a gene rearrangement involving …


Further Recommendations Of The International Paediatric Brain Injury Society (Ipbis) For The Post-Acute Rehabilitation Of Children With Acquired Brain Injury, Mark A Linden, Audrey Mckinlay, Carol Hawley, Catherine Aaro-Jonsson, Ingela Kristiansen, Andreas Meyer-Heim, Linda Ewing-Cobbs, Beth Wicks, Miriam H Beauchamp, Rajendra Prasad, Board Of Directors Of The Ipbis Affiliations Feb 2024

Further Recommendations Of The International Paediatric Brain Injury Society (Ipbis) For The Post-Acute Rehabilitation Of Children With Acquired Brain Injury, Mark A Linden, Audrey Mckinlay, Carol Hawley, Catherine Aaro-Jonsson, Ingela Kristiansen, Andreas Meyer-Heim, Linda Ewing-Cobbs, Beth Wicks, Miriam H Beauchamp, Rajendra Prasad, Board Of Directors Of The Ipbis Affiliations

Faculty, Staff and Student Publications

Background: Paediatric acquired brain injury is a life-long condition which impacts on all facets of the individual's lived experience. The existing evidence base continues to expand and new fields of enquiry are established as clinicians and researchers uncover the extent of these impacts.

Primary objective: To add to recommendations described in the International Paediatric Brain Injury Society's 2016 paper on post-acute care for children with acquired brain injury and highlight new areas of enquiry.

Review of information: Recommendations were made based on the opinions of a group of experienced international clinicians and researchers who are current or past members of …


“You Are Not The Same Person You Were:” On Diagnosis Seeking During A Liminal Period And Systemic Lupus Erythematosus, Kaylee A. Appleton Feb 2024

“You Are Not The Same Person You Were:” On Diagnosis Seeking During A Liminal Period And Systemic Lupus Erythematosus, Kaylee A. Appleton

USF Tampa Graduate Theses and Dissertations

“You are the healthiest looking sick person I’ve ever met”

(Daphne, 62)

Systemic Lupus Erythematosus (SLE) is one of many chronic illnesses considered to be “invisible.” Once the onset of symptoms occurs, the illness can drastically change the dynamic of an individual's life in ways that may not be noticeable to others, even before a chronic illness diagnosis. I discuss how these individuals experience the liminal period of developing symptoms and seeking a diagnosis. Furthermore, I discuss vignettes that exemplifies the occurrence of a liminal state while looking at the current for-profit set-up of healthcare in the United States. Utilizing …


Cros Or Hearing Aid? Selecting The Ideal Solution For Unilateral Ci Patients With Limited Aidable Hearing In The Contralateral Ear, Sarah Lively, Smita Agrawal, Matthew Stewart, Robert Dwyer, Laura Strobel, Paula Marcinkevich, Chris Hetlinger, Julia Croce Feb 2024

Cros Or Hearing Aid? Selecting The Ideal Solution For Unilateral Ci Patients With Limited Aidable Hearing In The Contralateral Ear, Sarah Lively, Smita Agrawal, Matthew Stewart, Robert Dwyer, Laura Strobel, Paula Marcinkevich, Chris Hetlinger, Julia Croce

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

A hearing aid or a contralateral routing of signal device are options for unilateral cochlear implant listeners with limited hearing in the unimplanted ear; however, it is uncertain which device provides greater benefit beyond unilateral listening alone. Eighteen unilateral cochlear implant listeners participated in this prospective, within-participants, repeated measures study. Participants were tested with the cochlear implant alone, cochlear implant + hearing aid, and cochlear implant + contralateral routing of signal device configurations with a one-month take-home period between each in-person visit. Audiograms, speech perception in noise, and lateralization were evaluated. Subjective feedback was obtained via questionnaires. Marked improvement in …


Fast And Slow: Recording Neuromodulator Dynamics Across Both Transient And Chronic Time Scales, Pingchuan Ma, Peter Chen, Elizabeth I Tilden, Samarth Aggarwal, Anna Oldenborg, Yao Chen Feb 2024

Fast And Slow: Recording Neuromodulator Dynamics Across Both Transient And Chronic Time Scales, Pingchuan Ma, Peter Chen, Elizabeth I Tilden, Samarth Aggarwal, Anna Oldenborg, Yao Chen

2020-Current year OA Pubs

Neuromodulators transform animal behaviors. Recent research has demonstrated the importance of both sustained and transient change in neuromodulators, likely due to tonic and phasic neuromodulator release. However, no method could simultaneously record both types of dynamics. Fluorescence lifetime of optical reporters could offer a solution because it allows high temporal resolution and is impervious to sensor expression differences across chronic periods. Nevertheless, no fluorescence lifetime change across the entire classes of neuromodulator sensors was previously known. Unexpectedly, we find that several intensity-based neuromodulator sensors also exhibit fluorescence lifetime responses. Furthermore, we show that lifetime measures in vivo neuromodulator dynamics both …


Single Cell-Transcriptomic Analysis Informs The Lncrna Landscape In Metastatic Castration Resistant Prostate Cancer, Debanjan Saha, Ha X Dang, Meng Zhang, David A Quigley, Felix Y Feng, Christopher A Maher Feb 2024

Single Cell-Transcriptomic Analysis Informs The Lncrna Landscape In Metastatic Castration Resistant Prostate Cancer, Debanjan Saha, Ha X Dang, Meng Zhang, David A Quigley, Felix Y Feng, Christopher A Maher

2020-Current year OA Pubs

Metastatic castration-resistant prostate cancer (mCRPC) is a lethal form of prostate cancer. Although long-noncoding RNAs (lncRNAs) have been implicated in mCRPC, past studies have relied on bulk sequencing methods with low depth and lack of single-cell resolution. Hence, we performed a lncRNA-focused analysis of single-cell RNA-sequencing data (n = 14) from mCRPC biopsies followed by integration with bulk multi-omic datasets. This yielded 389 cell-enriched lncRNAs in prostate cancer cells and the tumor microenvironment (TME). These lncRNAs demonstrated enrichment with regulatory elements and exhibited alterations during prostate cancer progression. Prostate-lncRNAs were correlated with AR mutational status and response to treatment with …


Efficacy Of Suture Versus Sutureless Technique After Periodontal Flap Surgery – A Split Mouth Study, Saranya M Feb 2024

Efficacy Of Suture Versus Sutureless Technique After Periodontal Flap Surgery – A Split Mouth Study, Saranya M

Annual Research Symposium

Suturing is an integral part of periodontal flap surgery, but it has disadvantages such as difficulty in maintaining oral hygiene, increased post-operative discomfort, and higher infection rate. To overcome these problems, a search for an alternative like tissue adhesives, possibly a sutureless technique has been experimented. The aim of the study was to compare the stability & healing properties after periodontal flap surgery using tissue adhesive and surgical sutures.


Lack Of Alternatives To Colonoscopy Limits Care Of Patients Unable To Complete Bowel Preparation, Tala Al-Saghir Feb 2024

Lack Of Alternatives To Colonoscopy Limits Care Of Patients Unable To Complete Bowel Preparation, Tala Al-Saghir

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report using:

Benech N, Vinet O, Gaudin JL, et al.: The ONECC Study Group. Colon capsule endoscopy in clinical practice: lessons from a national 5-year observational prospective cohort. Endosc Int Open. 2021;9(10):E1542-E1548. https://doi.org/10.1055/a-1526-09231

for a patient with incomplete bowel preparation and colonoscopy.


Multiple Daily Injection Insulin Regimen Is An Effective, And More Economical, Alternative To Continuous Insulin Infusion For Type 1 Diabetics, Julia Yee Feb 2024

Multiple Daily Injection Insulin Regimen Is An Effective, And More Economical, Alternative To Continuous Insulin Infusion For Type 1 Diabetics, Julia Yee

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report using:

Heller S, White D, Lee E, et al. A cluster randomised trial, cost-effectiveness analysis and psychosocial evaluation of insulin pump therapy compared with multiple injections during flexible intensive insulin therapy for type 1 diabetes: the REPOSE Trial. Health Technol Assess. 2017 Apr;21(20):1-278. https://doi.org/10.3310/hta21200

for a patient with type 1 diabetes.


Kinship, Gift Exchange, And The Management Of Diabetes, Bryen Turco, Vito Agrusa, Laila Abdallah, James Peter Meza Feb 2024

Kinship, Gift Exchange, And The Management Of Diabetes, Bryen Turco, Vito Agrusa, Laila Abdallah, James Peter Meza

Clinical Research in Practice: The Journal of Team Hippocrates

The authors examine the impact of kinship structures on the management poorly controlled type 2 diabetes


Medical School Watercooler Newsletter - February 22, 2024, Lindsey Lyle Feb 2024

Medical School Watercooler Newsletter - February 22, 2024, Lindsey Lyle

Watercooler Newsletter

This is the February 22, 2024 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

  • Meet a Med Student: Mary Katherine Moore
  • Student interest group receives Sparking Interest in Pathology Award
  • GHHS hosts Solidarity Week for Compassionate Care
  • Developmental-behavioral pediatrician joins pediatrics faculty