Medicine and Health Sciences Commons^™

Dean's Update, April 2024, Neil W. Schluger

SOM Dean's Research Newsletter

No abstract provided.

Loma Linda Nurse - Vol. 31, Loma Linda University School Of Nursing

Loma Linda Nurse

FEATURES

4 | The Next Chapter for LLUSN

8 | 50 Years of West Hall

10 | Dr. Shawn Collins Named New Dean

12 | Dr. Gloria Huerta Named New Associate Dean

14 | Adventist Nursing Theory with Dr. Patricia Jones

LLUSN HIGHLIGHTS

16-23 | ALUMNI NEWS

24-27 | ACADEMICS

28-32 | HOMECOMING

33-35 | FACULTY UPDATES

Adaptation Of The Dangerous Decibels Program To Youth In Farming, Whitney Paige Hodges

Doctoral Scholarly Projects & Capstones

The prevalence of noise-induced hearing loss (NIHL) among youth in farming communities is a pressing issue, primarily due to prolonged exposure to loud farm environments. Effective health communication techniques that focus on education and NIHL prevention are essential to convey critical health messages to young individuals in agricultural communities. The Dangerous Decibels program employs these techniques, emphasizing the identification of hazardous noises, understanding the consequences of noise overexposure, and promoting hearing protection measures. It is crucial to acknowledge that the effectiveness of health communication messages can vary among different social groups, necessitating a tailored program to effectively inform young individuals …

A Word From The Writing Team (April 2024), Pam Walter, Mfa, Liz Declan, Ma, Mfa

A Word From the Writing Team (Newsletter)

This issue includes:

• Join Us for Our Virtual Writing Retreat on April 5th
• Attend a Packback Workshop
• Check Out the Spring 2024 Research Support Newsletter
• Learn about the Ethics of AI at Jefferson's Research Compliance Symposium
• Attend a Reception for the Drs. Theresa and Charles Yeo Writing Prize Winners on April 25th
• Publication Spotlight
• Jefferson's AI Library Guide is Available on the Library Website
• The OPWPC Canvas Page Offers Helpful Tools
• Scott Memorial Library Archive Renovations are Almost Done!
• Wiley Open Access Fees Waived for Jefferson Authors

Use Of Translational Science, Continuous Glucose Monitoring In The Primary Care Setting For Management Of Nesidioblastosis: A Case Report And Literature Review, Karuna Manandhar, Othman Farahneh, Ahmad Damlakhy, Ali Lattouf, Gerardo Munoz-Monaco

School of Medicine Publications

Nesidioblastosis is a term used to describe histologic changes in the pancreatic cell, which are defined by beta cell hypertrophy and the formation of ductoinsular complexes. It is a disease previously most extensively identified in neonates and is a rare cause of endogenous hypoglycemia in the adult population. However, with increasing numbers of gastric bypass surgeries for the management of obesity in recent years, there has been a growing number of populations with post-gastric bypass surgery-related nesidioblastosis. Here, we will present a case of a 60-year-old female with a history of Roux-en-Y gastric bypass (RYGB) surgery who initially presented with …

Barriers To Escape: How Homelessness And Drug Addiction Prevent Women From Escaping Sex Trafficking And Commercial Sex, Laura J. Lederer, Mckamie J. Chandler, Stanley Stinson

Dignity: A Journal of Analysis of Exploitation and Violence

Victims of sex trafficking and women purportedly involved in prostitution voluntarily face a complex web of interconnected challenges when attempting to escape their current circumstances. By analyzing the shared and distinct challenges faced by these women, the paper aims to inform policymakers and service providers, offering recommendations to empower women seeking to escape exploitation through multidisciplinary and interconnected networks of providers. This study surveyed 74 women in Detroit, Michigan, using nonprobability convenience sampling over a 10-month period in 2020. It compared three groups of women who self-reported as victims of sex trafficking, women who voluntarily engaged in some form of …

Brain Artery Diameters And Risk Of Dementia And Stroke, Jesus D. Melgarejo, Kursat Gurel, Cassidy Rose Compton, Minghua Liu, Vanessa Guzman, Stephanie Assuras, Bonnie E. Levin, Mitchell S. V. Elkind, M. Kamran Ikram, Maryam Kavousi

School of Medicine Publications

Introduction: We tested the association of brain artery diameters with dementia and stroke risk in three distinct population-based studies using conventional T2-weighted brain magnetic resonance imaging (MRI) images.

Methods: We included 8420 adults > 40 years old from three longitudinal population-based studies with brain MRI scans. We estimated and meta-analyzed the hazard ratios (HRs) of the brain and carotids and basilar diameters associated with dementia and stroke.

Result: Overall and carotid artery diameters > 95th percentile increased the risk for dementia by 1.74 (95% confidence interval [CI], 1.13-2.68) and 1.48 (95% CI, 1.12-1.96) fold, respectively. For stroke, meta-analyses yielded HRs of 1.59 …

The Internist's Post V.1 N.2, The University Of Texas Rio Grande Valley. School Of Medicine, Edgar Dorsey Trevino, Diana Othon Martinez, Jian Garcia Cruz, Eunbee Cho, Roque Mifuji Lira, Martha Solis

School of Medicine Publications

Newsletter of the University of Texas Rio Grande Valley School of Medicine - Internal Medicine Residency Program.

Linking Type And Extent Of Head Trauma To Cavum Septum Pellucidum In Older Adults With And Without Alzheimer Disease And Related Dementias, Breton M. Asken, Jeremy A. Tanner, Lawren Vandevrede, Alexandra Apple, Marianne Chapleau, Leslie S. Gaynor, Courtney Lane-Donovan, Steven Lenio, Golnaz Yadollahikhales, Shannon Lee

School of Medicine Publications

Background and objectives: Cavum septum pellucidum (CSP) is a common but nonspecific MRI finding in individuals with prior head trauma. The type and extent of head trauma related to CSP, CSP features specific to head trauma, and the impact of brain atrophy on CSP are unknown. We evaluated CSP cross-sectionally and longitudinally in healthy and clinically impaired older adults who underwent detailed lifetime head trauma characterization.

Methods: This is an observational cohort study of University of California, San Francisco Memory and Aging Center participants (healthy controls [HCs], those with Alzheimer disease or related dementias [ADRDs], subset with traumatic encephalopathy syndrome …

Vascular Complications And Outcomes Following Transcatheter Aortic Valve Replacement In Patients On Chronic Steroid Therapy: A Meta-Analysis, Song Peng Ang, Jia Ee Chia, Vikash Jaiswal, Muhammad Hanif, Ananya Vadhera, Sudarshan Gautam, Anuradha Raut, Saira Rafaqat, Vamsikalayan Borra, Harshwardhan Khandait

School of Medicine Publications

Background: Chronic steroid (CS) therapy was reportedly linked to increased vascular complications following percutaneous coronary intervention. However, its association with vascular complications after transcatheter aortic valve replacement (TAVR) remained uncertain, with conflicting results being reported.

Objective: The authors aimed to compare the rate of vascular complications and outcomes between patients with and without CS use after TAVR.

Methods: The authors conducted a comprehensive literature search in PubMed, Embase, and Cochrane databases from their inception until 18th April 2022 for relevant studies. Endpoints were described according to Valve Academic Research Consortium-2 definitions. Effect sizes were pooled using DerSimonian and Laird random-effects …

Psychometric Evaluation Of The “Providing Validation” Measure In Vascular Anomalies, Bryan A. Sisk, Anna M. Kerr, Amy R. Newman, Dandan Chen, Jennifer W. Mack, Bryce B. Reeve

College of Nursing Faculty Research and Publications

We assessed the psychometric properties of the “providing validation” subscale of PedCOM measures for parents of children with vascular anomalies and adult patients. A total of 139 adult patients and 78 parents completed surveys. The mean score for patients was 3.7 (standard deviation 1.0), and for parents was 4.0 (standard deviation 0.9). “Providing validation” measures demonstrated high internal consistency and good model fit to a unidimensional model for both patients and parents using confirmatory factor analysis. The measures also demonstrated convergent validity with co-administered measures. This study demonstrated the validity of “providing validation” measures for parents and adult patients with …

Effect Of Layer Thickness, Inner Structure, And Implant Angulation On The Accuracy Of 3d Printed Models With Implant Analogs, Omar Elsergany

Dentistry

Objective: This study evaluated the effect of layer thickness, model inner structure, and im- plant angulation on the accuracy of 3D printed models with repositional analogs.

Materials and methods: 126 models designed to receive all-on-4 implant retained fixed den- tal prosthesis were 3D printed. Models were divided into 2 groups (n=63) according to posterior implant angulation (Group 1; 30 ̊ and group 2;45 ̊). The models were then divided into three sub- groups (n=21) according to the printing layer thickness (Group a; 50 μm, group b; 100 μm, and group c; 150 μm). Each subgroup was later subdivided into 3 …

Color Stability And Marginal Adaptation Of Ceramic Veneers Cemented Using Different Composite Resins, Basma Refaat Fayad, Maged Zohdy, Engy Adel Farag, Ghada Hussein

Dentistry

BACKGROUND: The purpose of this study was to compare the color stability and marginal adaption of lithium disilicate veneers before and after thermocycling using various resin composite materials employed as cement. METHODS: Laminate veneer preparation was done on an acrylic tooth according to standardized procedures. The veneer preparations were duplicated into twenty-one dies. The veneers were fabricated from lithium disilicate using the CEREC in Lab system. According to the cement type, the twenty-one die specimens were randomly divided into three equal groups: group I, with light cured adhesive resin cement (N.=7), group II, with owable light cured composite, and group …

Analytical Challenges In Omics Research On Asthma And Allergy: A National Institute Of Allergy And Infectious Diseases Workshop, Supinda Bunyavanich, Patrice M Becker, Matthew C Altman, Jessica Lasky-Su, Carole Ober, Karsten Zengler, Evgeny Berdyshev, Richard Bonneau, Talal Chatila, Nilanjan Chatterjee, Kian Fan Chung, Colleen Cutcliffe, Wendy Davidson, Gang Dong, Gang Fang, Patricia Fulkerson, Blanca E Himes, Liming Liang, Rasika A Mathias, Shuji Ogino, Joseph Petrosino, Nathan D Price, Eric Schadt, James Schofield, Max A Seibold, Hanno Steen, Lisa Wheatley, Hongmei Zhang, Alkis Togias, Kohei Hasegawa

Center for Medical Ethics and Health Policy Staff Publications

Studies of asthma and allergy are generating increasing volumes of omics data for analysis and interpretation. The National Institute of Allergy and Infectious Diseases (NIAID) assembled a workshop comprising investigators studying asthma and allergic diseases using omics approaches, omics investigators from outside the field, and NIAID medical and scientific officers to discuss the following areas in asthma and allergy research: genomics, epigenomics, transcriptomics, microbiomics, metabolomics, proteomics, lipidomics, integrative omics, systems biology, and causal inference. Current states of the art, present challenges, novel and emerging strategies, and priorities for progress were presented and discussed for each area. This workshop report summarizes …

A Targeted Proteomics Method For Quantifying Plasma Apolipoprotein Kinetics In Individual Mice Using Stable Isotope Labeling, Baohai Shao, Masami Shimizu-Albergine, Farah Kramer, Jenny E Kanter, Jay W Heinecke, Tomas Vaisar, Bettina Mittendorfer, Bruce W Patterson, Karin E Bornfeldt

2020-Current year OA Pubs

Altered apolipoprotein kinetics play a critical role in promoting dyslipidemia and atherogenesis. Human apolipoprotein kinetics have been extensively evaluated, but similar studies in mice are hampered by the lack of robust methods suitable for the small amounts of blood that can be collected at sequential time points from individual mice. We describe a targeted liquid chromatography tandem mass spectrometry method for simultaneously quantifying the stable isotope enrichment of several apolipoproteins represented by multiple peptides in serial blood samples (15 μl each) obtained after retro-orbital injection of

Early Treatment With Fluvoxamine, Bromhexine, Cyproheptadine, And Niclosamide To Prevent Clinical Deterioration In Patients With Symptomatic Covid-19: A Randomized Clinical Trial, Dhammika Leshan Wannigama, Angela M Reiersen, Et Al.

2020-Current year OA Pubs

BACKGROUND: Repurposed drugs with host-directed antiviral and immunomodulatory properties have shown promise in the treatment of COVID-19, but few trials have studied combinations of these agents. The aim of this trial was to assess the effectiveness of affordable, widely available, repurposed drugs used in combination for treatment of COVID-19, which may be particularly relevant to low-resource countries.

METHODS: We conducted an open-label, randomized, outpatient, controlled trial in Thailand from October 1, 2021, to June 21, 2022, to assess whether early treatment within 48-h of symptoms onset with combinations of fluvoxamine, bromhexine, cyproheptadine, and niclosamide, given to adults with confirmed mild …

The Performance Of 11 Fingertip Pulse Oximeters During Hypoxemia In Healthy Human Participants With Varied, Quantified Skin Pigment, Gregory Leeb, Leonid Shmuylovich, Et Al.

2020-Current year OA Pubs

BACKGROUND: Fingertip pulse oximeters are widely available, inexpensive, and commonly used to make clinical decisions in many settings. Device performance is largely unregulated and poorly characterised, especially in people with dark skin pigmentation.

METHODS: Eleven popular fingertip pulse oximeters were evaluated using the US Food and Drug Administration (FDA) Guidance (2013) and International Organization for Standardization Standards (ISO, 2017) in 34 healthy humans with diverse skin pigmentation utilising a controlled desaturation study with arterial oxygen saturation (SaO 2) plateaus between 70% and 100%. Skin pigmentation was assessed subjectively using a perceived Fitzpatrick Scale (pFP) and objectively using the individual typology …

Degenerative Meniscus Tears Treated Nonoperatively With Platelet-Rich Plasma Yield Variable Clinical And Imaging Outcomes: A Systematic Review, Varun Gopinatth, Anjay K Batra, Jorge Chahla, Matthew V Smith, Matthew J Matava, Robert H Brophy, Derrick M Knapik

2020-Current year OA Pubs

PURPOSE: To perform a systematic review on clinical and radiologic outcomes for meniscus tears treated nonoperatively with platelet-rich plasma (PRP).

METHODS: A literature search was performed according to the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines using keywords and Boolean operators in SCOPUS, PubMed, Medline, and the Cochrane Central Register for Controlled Trials in April 2023. Inclusion criteria were limited to Level I to IV human studies reporting on outcomes of meniscus tears treated nonoperatively with PRP.

RESULTS: A total of 6 studies, consisting of 184 patients, were identified. There was 1 Level I study and 5 …

Trapdoor Endarterectomy For Coral Reef Plaque Of The Paravisceral Aorta In The Modern Era, Jackson S Burton, Nathan M Droz, Vipul Khetarpaul, Luis A Sanchez, J Westley Ohman

2020-Current year OA Pubs

Coral reef atherosclerosis of the paravisceral aorta is a rare disease whose description is confined to before contemporary vascular surgical techniques. This study aims to describe the characteristics and outcomes of patients with coral reef aorta treated with trapdoor endarterectomy at a single high-volume quaternary referral center since 2010. From 2010 to 2022, 14 patients with coral reef aorta were treated with trapdoor endarterectomy. The patient data were obtained via a retrospective medical record review. The patients were predominantly women (79%) with a median age of 65 years (interquartile range [IQR], 60-70 years). The patients universally had a tobacco smoking …

Hspa9/Mortalin Inhibition Disrupts Erythroid Maturation Through A Tp53-Dependent Mechanism In Human Cd34+ Hematopoietic Progenitor Cells, Christopher Butler, Morgan Dunmire, Jaebok Choi, Gabor Szalai, Anissa Johnson, Wei Lei, Xin Chen, Liang Liu, Wei Li, Matthew J Walter, Tuoen Liu

2020-Current year OA Pubs

Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic stem cell malignancies characterized by abnormal hematopoietic cell maturation, increased apoptosis of bone marrow cells, and anemia. They are the most common myeloid blood cancers in American adults. The full complement of gene mutations that contribute to the phenotypes or clinical symptoms in MDS is not fully understood. Around 10%-25% of MDS patients harbor an interstitial heterozygous deletion on the long arm of chromosome 5 [del(5q)], creating haploinsufficiency for a large set of genes, including HSPA9. The HSPA9 gene encodes for the protein mortalin, a highly conserved heat shock protein …

Adipose Tissue Peroxisomal Lipid Synthesis Orchestrates Obesity And Insulin Resistance Through Lxr-Dependent Lipogenesis, Brian Kleiboeker, Anyuan He, Min Tan, Dongliang Lu, Donghua Hu, Xuejing Liu, Parniyan Goodarzi, Fong-Fu Hsu, Babak Razani, Clay F Semenkovich, Irfan J Lodhi

2020-Current year OA Pubs

OBJECTIVE: Adipose tissue mass is maintained by a balance between lipolysis and lipid storage. The contribution of adipose tissue lipogenesis to fat mass, especially in the setting of high-fat feeding, is considered minor. Here we investigated the effect of adipose-specific inactivation of the peroxisomal lipid synthetic protein PexRAP on fatty acid synthase (FASN)-mediated lipogenesis and its impact on adiposity and metabolic homeostasis.

METHODS: To explore the role of PexRAP in adipose tissue, we metabolically phenotyped mice with adipose-specific knockout of PexRAP. Bulk RNA sequencing was used to determine transcriptomic responses to PexRAP deletion and

RESULTS: Adipose-specific PexRAP deletion promoted diet-induced …

Practical Considerations For Delandistrogene Moxeparvovec Gene Therapy In Patients With Duchenne Muscular Dystrophy, Jerry R Mendell, Crystal Proud, Craig M Zaidman, Stefanie Mason, Eddie Darton, Shufang Wang, Christoph Wandel, Alexander P Murphy, Eugenio Mercuri, Francesco Muntoni, Craig M Mcdonald

2020-Current year OA Pubs

BACKGROUND: Delandistrogene moxeparvovec is a gene transfer therapy approved in the United States, United Arab Emirates, and Qatar for the treatment of ambulatory patients aged four through five years with a confirmed Duchenne muscular dystrophy (DMD)-causing mutation in the DMD gene. This therapy was developed to address the underlying cause of DMD through targeted skeletal, respiratory, and cardiac muscle expression of delandistrogene moxeparvovec micro-dystrophin, an engineered, functional dystrophin protein.

METHODS: Drawing on clinical trial experience from Study 101 (NCT03375164), Study 102 (NCT03769116), and ENDEAVOR (Study 103; NCT04626674), we outline practical considerations for delandistrogene moxeparvovec treatment.

RESULTS: Before infusion, the following …

T-Cell Acute Lymphoblastic Leukemia/Lymphoma (T-All) With Negative Screening Immaturity Markers And Gamma-Delta Receptor Expression, Maria Faraz, Anita Parmigiani, Nina Monkash, Anne Chen

2020-Current year OA Pubs

T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) is characterized by the combination of T-cell lineage and the presence of immaturity marker(s). Sometimes, the most common immaturity markers for initial flow cytometry screening in T-ALL may be negative, which can be a diagnostic pitfall. When a lack of common first-line immaturity markers is encountered in combination with gamma/delta T-cell receptor expression, a misdiagnosis of mature gamma-delta T-cell leukemia/lymphoma could be rendered. Here, we discuss two T-ALL cases with the absence of common flow cytometry immaturity markers and positive gamma/delta receptor expression.

Changing Perceptions About The Dermatology Residency Application Process Among Applicants And Program Directors: 2020-2022, Fatuma-Ayaan B. Rinderknecht, Kandice C. Bailey, Danielle E. Novack, Adena E. Rosenblatt, Dana Dunleavy, Bobby D. Naemi, Ilana S. Rosman, Ammar Ahmed, Scott Worswick

2020-Current year OA Pubs

Importance Over the last two years, dermatology has undergone significant reforms in the residency application process in efforts to reduce applicant stress, increase equity, and due to the COVID-19 pandemic. Objective We aimed to determine applicant and program director (PD) perspectives in implementing these changes over the last two application cycles. Design, setting, and participants Anonymous online surveys were administered by the Association of American Medical Colleges (AAMC) to PDs and applicants from the 2021-2022 dermatology residency application cycle. These results were compared with similar online surveys distributed after the 2020-2021 cycle. Results Coordinated interview release was introduced in the …

Threat Experiences Moderate The Link Between Hippocampus Volume And Depression Symptoms Prospectively In Adolescence, Max P Herzberg, Meriah L Dejoseph, Joan Luby, Deanna M Barch

2020-Current year OA Pubs

Identifying neuroimaging risk markers for depression has been an elusive goal in psychopathology research. Despite this, smaller hippocampal volume has emerged as a potential risk marker for depression, with recent research suggesting this association is moderated by family income. The current pre-registered study aimed to replicate and extend these findings by examining the moderating role of family income and three dimensions of environmental experience on the link between hippocampus volume and later depression. Data were drawn from the Adolescent Brain Cognitive Development (ABCD) study and were comprised of 6693 youth aged 9-10 years at baseline. Results indicated that psychosocial threat …

Pyridoxine Challenge Reflects Pediatric Hypophosphatasia Severity And Thereby Examines Tissue-Nonspecific Alkaline Phosphatase's Role In Vitamin B6 Metabolism, Michael P Whyte, Fan Zhang, Karen E Mack, Deborah Wenkert, Gary S Gottesman, Karen L Ericson, Jeffrey T Cole, Stephen P Coburn

2020-Current year OA Pubs

Alkaline phosphatase (ALP) is detected in most human tissues. However, ALP activity is routinely assayed using high concentrations of artificial colorimetric substrates in phosphate-free laboratory buffers at lethal pH. Hypophosphatasia (HPP) is the inborn-error-of-metabolism caused by loss-of-function mutation(s) of the ALPL gene that encodes the ALP isoenzyme expressed in bone, liver, kidney, and elsewhere and is therefore designated "tissue-nonspecific" ALP (TNSALP). Consequently, HPP harbors clues concerning the biological function of this phosphohydrolase that is anchored onto the surface of cells. The biochemical signature of HPP features low serum ALP activity (hypophosphatasemia) together with elevated plasma levels of three natural substrates …

Safety And Effectiveness Of Diazepam Nasal Spray In Male And Female Patients: Post Hoc Analysis Of Data From A Phase 3 Safety Study, James W Wheless, Robert Edward Hogan, Charles S Davis, Enrique Carrazana, Adrian L Rabinowicz

2020-Current year OA Pubs

Sex differences in drug pharmacokinetics include variations in the expression of the cytochrome P450 enzymes, which are involved in the metabolism of benzodiazepines. It is unclear whether sex influences outcomes associated with intranasally administered drugs. A post hoc analysis of sex differences was conducted to evaluate the effectiveness and safety of diazepam nasal spray, which included examining changes in the number of days between seizure clusters over time (SEIzure interVAL [SEIVAL]). Diazepam nasal spray is approved for acute treatment of seizure clusters in patients with epilepsy aged ≥6 years. Data from a phase 3 safety study were used to determine …

Anatomical Registration Of Intracranial Electrodes. Robust Model-Based Localization And Deformable Smooth Brain-Shift Compensation Methods, Alejandro Omar Blenkmann, Sabine Liliana Leske, Anaïs Llorens, Jack J Lin, Edward F Chang, Peter Brunner, Gerwin Schalk, Jugoslav Ivanovic, Pål Gunnar Larsson, Robert Thomas Knight, Tor Endestad, Anne-Kristin Solbakk

2020-Current year OA Pubs

BACKGROUND: Intracranial electrodes are typically localized from post-implantation CT artifacts. Automatic algorithms localizing low signal-to-noise ratio artifacts and high-density electrode arrays are missing. Additionally, implantation of grids/strips introduces brain deformations, resulting in registration errors when fusing post-implantation CT and pre-implantation MR images. Brain-shift compensation methods project electrode coordinates to cortex, but either fail to produce smooth solutions or do not account for brain deformations.

NEW METHODS: We first introduce GridFit, a model-based fitting approach that simultaneously localizes all electrodes' CT artifacts in grids, strips, or depth arrays. Second, we present CEPA, a brain-shift compensation algorithm combining orthogonal-based projections, spring-mesh models, …

Neutrophils Are Indispensable For Adverse Cardiac Remodeling In Heart Failure, Sergey Antipenko, Nicolas Mayfield, Miki Jinno, Matthias Gunzer, Mohamed Ameen Ismahil, Tariq Hamid, Sumanth D Prabhu, Gregg Rokosh

2020-Current year OA Pubs

Persistent immune activation contributes significantly to left ventricular (LV) dysfunction and adverse remodeling in heart failure (HF). In contrast to their well-known essential role in acute myocardial infarction (MI) as first responders that clear dead cells and facilitate subsequent reparative macrophage polarization, the role of neutrophils in the pathobiology of chronic ischemic HF is poorly defined. To determine the importance of neutrophils in the progression of ischemic cardiomyopathy, we measured their production, levels, and activation in a mouse model of chronic HF 8 weeks after permanent coronary artery ligation and large MI. In HF mice, neutrophils were more abundant both …

Feasibility Of Surface-Guidance Combined With Cbct For Intra-Fractional Breath-Hold Motion Management During Ethos Rt, Taeho Kim, Eric Laugeman, Kendall Kiser, Joshua Schiff, Shanti Marasini, Alex Price, H Michael Gach, Nels Knutson, Pamela Samson, Clifford Robinson, Casey Hatscher, Lauren Henke

2020-Current year OA Pubs

PURPOSE: High-quality CBCT and AI-enhanced adaptive planning techniques allow CBCT-guided stereotactic adaptive radiotherapy (CT-STAR) to account for inter-fractional anatomic changes. Studies of intra-fractional respiratory motion management with a surface imaging solution for CT-STAR have not been fully conducted. We investigated intra-fractional motion management in breath-hold Ethos-based CT-STAR and CT-SBRT (stereotactic body non-adaptive radiotherapy) using optical surface imaging combined with onboard CBCTs.

METHODS: Ten cancer patients with mobile lower lung or upper abdominal malignancies participated in an IRB-approved clinical trial (Phase I) of optical surface image-guided Ethos CT-STAR/SBRT. In the clinical trial, a pre-configured gating window (± 2 mm in AP …