Medicine and Health Sciences Commons^™

Relative Uptake Of Tomato Carotenoids By In Vitro Intestinal And Prostate Cancer Cells, Nancy E Moran, Brianna Alexander, Shivi Garg, Nathan Marchant, Noor A Hason

Children’s Nutrition Research Center Staff Publications

Background: Consumption of tomatoes and tomato carotenoids is associated with a reduced risk of prostate cancer. Prostate tissue accumulates tomato carotenoids, including lycopene, β-carotene, and phytoene. Phytoene accumulation is relatively greater in the prostate than that of lycopene, but the metabolic determinants of tissue carotenoid profiles are poorly understood.

Objectives: The purpose of this study was to determine if differences in stability, cellular uptake, and clearance of phytoene compared with lycopene or β-carotene by prostate and intestinal cells may explain differences in observed tissue carotenoid profiles.

Methods: Gene and protein expression for carotenoid metabolism in prostate cell lines were analyzed …

Random C-Peptide And Islet Antibodies At Onset Predict Β Cell Function Trajectory And Insulin Dependence In Pediatric Diabetes, Mustafa Tosur, Saima Deen, Xiaofan Huang, Serife Uysal, Marcela Astudillo, Richard A Oram, Maria J Redondo, Farook Jahoor, Ashok Balasubramanyam

Children’s Nutrition Research Center Staff Publications

Objective: Identification of prognostic biomarkers in pediatric diabetes is important for precision medicine. We assessed whether C-peptide and islet autoantibodies are useful to predict the natural history of children with new-onset diabetes.

Methods: We prospectively studied 72 children with new-onset diabetes (median follow-up: 8 months) by applying the Aβ classification system ("A+": islet autoantibody positive, "β+": random serum C-peptide ≥1.3 ng/mL at diagnosis). Beta-cell function was assessed longitudinally with 2 hours postprandial/stimulated urinary C-peptide-to-creatinine ratio (UCPCR) 3-12 weeks (V1) and 6 to 12 months after diagnosis (V2). We obtained a type 1 diabetes genetic risk score for each participant, and …

Are Prediction Models Moving Closer To Clinical Application In The Diagnosis Of Type Of Diabetes In Youth?, Fida Bacha

Children’s Nutrition Research Center Staff Publications

No abstract provided.

Are Leaders Born, Or Made?, William R. Chase D.D.S.

The Journal of the Michigan Dental Association

The debate over whether leaders are born or made persists, but effective leadership often results from a combination of innate traits and learned skills. Transformational leaders inspire and motivate others, while transactional leaders focus on tasks without fostering personal connections. Servant leadership, particularly valued in the dental profession, emphasizes service to others, aligning naturally with patient care. Leadership styles, such as coercive, authoritative, and affiliative, demonstrate the complexity of leadership dynamics. Renowned authors like John C. Maxwell and Daniel Goleman emphasize adaptability and the importance of being a leader whom people want to follow. Effective leadership transcends settings, offering focus, …

Genomic Analysis Of The Sars-Cov-2 Variants Circulated In The Philippines, 2020–2024, Arnie Dimaano, Kiana Dominique Carreon, Giselle Sophia Camaya, Irvin Rondolo, Jarel Elgin Tolentino

Biology Faculty Publications

Purpose

Genomic sequencing has been an invaluable tool to determine the evolution of SARS-CoV-2. In the present study, we provided a comprehensive description of the SARS-CoV-2 variants circulated in the Philippines.

Methods

The dataset from the human COVID-19 infections was acquired by downloading the sequences and their associated metadata spanning from March 2020 to April 2024. Then, we executed several filtering criteria to acquire the final dataset for the Philippine samples and performed spatial distribution analysis and phylogenetic tree construction of the reported SARS-CoV-2 sequences.

Results

A total of 16,679,203 SARS-CoV sequences were obtained, of which 17,393 (0.10 %) were …

Proteolytic Manipulation Of Neutrophil Responses And The Efferocytic Synapse By Porphyromonas Gingivalis., Kelley N. Cooper

Electronic Theses and Dissertations

Porphyromonas gingivalis (Pg) is etiologically associated with chronic periodontitis, a highly prevalent chronic inflammatory disease characterized by the destruction of hard and soft tissues of the periodontium. Pg is adapted to live in the human oral subgingival niche, a hostile environment dominated by excessive numbers of activated neutrophils and antimicrobial mediators. Its survival is contingent upon prompt and effective inactivation of neutrophil effector functions. In this dissertation, I uncover a novel pathogenic mechanism employed by Pg that disarms the antimicrobial capacity of live neutrophils and simultaneously sequesters them within macrophages. Mechanistically, RgpB, a cysteine protease produced by Pg …

Defining The Peripheral Plasticity Of Nociceptive Afferents Following Spinal Cord Injury And Physical Therapy Intervention., Morgan Julianna Forston

Electronic Theses and Dissertations

The focus of this dissertation is to explore the peripheral plasticity of nociceptive afferents following spinal cord injury (SCI) and whether it is exacerbated or induced when physical therapy-based muscle stretching, a therapy we have shown to be detrimental to locomotor recovery in rodents, is implemented post-SCI. Chapter I provides a brief introduction on sensory afferents with particular emphasis on nociceptive afferents and their multifaceted role within the peripheral and central nervous systems. Chapter II describes SCI epidemiology and common sensory related complications that occur in patients as well and pharmaco- and physical therapies that are employed post-SCI. Chapter III …

Patient, Provider, And Health System Characteristics Leading To The Delivery Of Low Value Health Care Services And Outcomes Of An Intervention For Mitigating Low Value Care., Philip Ray Rohrer

Electronic Theses and Dissertations

The United States spends more on health care than any other country, and Medicare accounted for nearly one-quarter of total personal health care spending in 2019. Waste within the health care system in the United States is estimated to represent approximately 25% of total U.S. health care expenditures. Low value care includes health care services that provide little or no benefit to patients, have potential to cause harm, incur unnecessary costs to patients, or waste limited healthcare resources. Low value care is estimated to represent roughly 10% of total health care waste, or between $75.7 billion and $101.2 billion dollars …

Understanding Carceral Pathways And Outcomes Of Marginalized Adults Who Use Drugs., Carmen Renee Mitchell

Electronic Theses and Dissertations

This dissertation is an examination of outcomes among substance users at various stages of the incarceration process divided among five chapters. Chapter One provides an overview of substance use disorder (SUD), incarceration, and wider justice system-involvement, and explores how the political economy of health theoretical framework can be applied to examine how the criminal justice system creates and perpetuates inequality among marginalized people who use substances. Chapter Two examines post-release health outcomes among the population of incarcerated people who use substances using a scoping review and finds that people in reentry with SUD have poorer overall outcomes that without transitional …

Plasma Resuscitation Attenuates Hemorrhage-Induced Glomerular Barrier Damage And Dysfunction., William Byron Risinger

Electronic Theses and Dissertations

Introduction: Acute renal dysfunction following traumatic injury and hemorrhagic shock carries significant morbidity and mortality. Despite an extensive understanding of renal tubule damage after injury, less is known regarding early alterations to the glomerular filtration barrier following hemorrhagic shock and resuscitation. Previously, our lab and others have demonstrated improved hepatic and intestinal microcirculatory parameters when resuscitation strategies incorporate fresh frozen plasma. In addition to improving end-organ perfusion, plasma reconstitutes the endothelial glycocalyx, an essential regulator of vascular permeability and microcirculatory function. However, the impact of plasma resuscitation on the glomerular glycocalyx and barrier following hemorrhage remains unknown. We hypothesized …

Cystic Fibrosis: The Past, Present, And Future Of An Ancient Disease, Abigail Pendell

Senior Honors Theses

Cystic fibrosis (CF) has been documented since 1595, but our understanding of the disease has evolved significantly only in recent decades. The purpose of this thesis is to trace the historical progression of CF from early observations of "salty" infants in medieval folklore up to modern observations of the disease, as well as describe the mechanisms and symptoms of CF and discuss current treatments and therapies. The multisystem nature of CF will be discussed, with a heavy focus on manifestations in the respiratory, digestive, and endocrine systems. Finally, advancements in treatments will be highlighted, such as CFTR modulators and multidisciplinary …

Management Of Possible Serious Bacterial Infections In Young Infants Where Referral Is Not Possible In The Context Of Existing Health System Structure In Mbeya, Tanzania: Experience And Lessons From The End Line Assessment, Esther Ngadaya, Alexander Manu, Mary Mmweteni, Dorica Burengelo, Doreen Philbert, Gibson Kagaruki, Kahabi Isangula, Mbazi Senkoro, Godfather Kimaro, Amos Kahwa

School of Nursing & Midwifery, East Africa

Severe bacterial infections (SBIs) are a leading cause of neonatal deaths in low- and middle-income countries. World Health Organization’s (WHO’s) guideline for outpatient management of danger signs indicating possible serious bacterial infections (PSBI) when referral is not possible was adopted by three pilot district councils in Mbeya Region, in Tanzania (Busekelo, Kyela and Mbarali Districts) in 2018 (the PSBI project). This study documented changes in practice during the PSBI project, and lessons learned. A cross-sectional study was conducted using both qualitative and quantitative data collection methods between July 2021 and January 2022, post-implementation. The study participants comprised stakeholders, health workers, …

An Evaluation Of The Effectiveness Of An Updated Pre-Service Midwifery Curriculum Integrated With Emergency Obstetric And Newborn Care In Kenya: A Cluster Randomised Controlled Trial, Duncan N. Shikuku, Catherine Mwaura, Peter Nandikove, Alphonce Uyara, Helen Allott, Lucy Waweru, Lucy Nyaga, Edna Tallam, Issak Bashir, Eunice Ndirangu

School of Nursing & Midwifery, East Africa

Introduction Quality midwifery education is central to improving midwifery service delivery and maternal and newborn health outcomes. In many settings, midwifery educators insufciently prepared for their teaching role and defcient curriculum compared to international standards afect the quality of healthcare provided by the midwifery graduates. This study assessed the efectiveness of an EmONC enhanced midwifery curriculum delivered by trained and mentored midwifery educators on the quality of education and student performance in Kenya.

Methods A cluster randomised controlled trial in 20 midwifery colleges (12 intervention, 8 control colleges). Educators in both arms received training in teaching/EmONC skills to deliver the …

Effectiveness Of Clinical Training In Influencing The Outcome Of Visual Inspection With Acetic Acid In Selected Facilities At A County In Kenya, Evah Maina, Abednego Ongeso, Nancy Maingi

School of Nursing & Midwifery, East Africa

Background: Cervical cancer remains a major health concern in developing countries, primarily due to the presence of human papillomavirus (HPV) types 16 and 18. Visual Inspection with Acetic Acid (VIA) is a common and affordable screening method, yet its effectiveness is closely tied to the skills and competency of healthcare providers. This study aimed to assess the impact of clinical training on improving VIA screening outcomes for cervical cancer in a county in Kenya.

Methods: Seven government health facilities equipped with cryotherapy machines were selected, with two healthcare providers sampled from each. A six-day VIA training intervention was conducted, combining …

The Relationship Between Early Dysphagia Screening And Incidence Of Pneumonia Among Acute Stroke Patients, Sabreen Elsedeek Ahmed Assistant Lecturer

Nursing

Background: Post-stroke dysphagia is a common complication of acute stroke, which could increase the risk of mortality and aspiration pneumonia. Aim: This study aimed to assess the relationship between early dysphagia screening and the incidence of pneumonia among acute stroke patients. Research design: A correlational descriptive design was utilized in this study. Setting: The study was conducted at the stroke and neurology intensive care units at As-Salam International Hospital. Subject: a purposive sample of (87) adult patients newly admitted with a diagnosis of acute stroke was included in the study. Tools: Three tools were used in this …

Impact Of Educational Sessions On Compassion Fatigue Among Home Healthcare Nurses: An Evidence-Based Practice Project, Adebimpe Blessing Ogunsefunmi

Doctor of Nursing Practice Projects

Background: Nurses are compassionate professionals who provide critical care, often at the expense of their own well-being. As the healthcare system faces rapid changes due to an aging population, nursing shortages, and the impact of COVID-19, compassion fatigue has become increasingly common. Despite its prevalence, few healthcare institutions address this issue. Objective: The objective of this DNP project was to evaluate whether weekly educational sessions enhanced perceptions of a positive quality of life, which typically declines with increased compassion fatigue, as measured by the Professional Quality of Life (ProQOL) scale. PICOT Question: Do weekly educational sessions on compassion fatigue …

Exploring Psychotic Symptoms Among Substance-Naïve Individuals And Recent Abstainers Without A Psychosis Diagnosis: A Cross-Country Study Across Kenya, Uganda, Ethiopia, And South Africa, Isaac Babu Kisiang'ani, Mohammed Aden, Henry R. Mwangi, Dickens Akena, Melkam Alemayehu, Julius Barasa, Bizu Gelaye, Stella Gichuru, Lukoye Atwoli, Symon M. Kariuki

Internal Medicine, East Africa

Psychotic symptoms are of increasing interest in mental health due to their predictive value for future psychotic disorders. While these symptoms are prevalent in the general population, their occurrence varies globally. This study aimed to explore the prevalence and factors associated with psychotic symptoms among individuals identified as substance-naïve and recent abstainers without a history of psychosis. A cross-sectional analysis was conducted on 11,686 participants who reported no lifetime substance use, no substance use in the previous three months, and did not have a diagnosis of psychosis. The study utilized the Psychosis Screening Questionnaire to estimate the one-year prevalence of …

Ten-Year Review Of St-Segment Elevation Myocardial Infarction (Stemi) In Tanzania: A Single Center Retrospective Review, Nadeem Kassam, Mohamed Varwani, Mzee Ngunga, Jeilan Mohamed, Mangaro Mabusi, James Orwa, Salim Surani, Robert Mvungi, Nasiruddin Jamal

Internal Medicine, East Africa

Introduction: Ischemic Heart Disease (IHD) is an emerging epidemic in sub-Saharan Africa (SSA). Although the true burden may be underreported in the African continent, it still remains one of the leading causes of death among adults aged above 60 years. ST-Segment Elevation Myocardial Infarction (STEMI) is a clinically time-sensitive fatal sequela of IHD with timely reperfusion by primary Percutaneous Coronary Intervention (PCI) being the gold standard of care. There has been steady progress in coronary care services in Tanzania, alongside a rise in IHD-related risk factors. However, data on this is limited. This study aimed to examine trends in …

The Reverse Lunge: A Descriptive Electromyographic Study, Barbara J. Hoogenboom, Madison Ferguson, Zac Krauss, Stephanie Tran

Open Access Publishing Support Funded Articles

Limited studies exist examining the reverse lunge. The purpose of this study was to describe the activation of the rectus femoris (RF), biceps femoris (BF), gluteus medius (GMed), and gluteus maximus (GMax) of both limbs during a bodyweight reverse lunge movement. A secondary purpose was to describe the phases of the stationary (non-moving) and lead (moving) limbs during the reverse lunge. Surface electromyography (EMG) was used to record the activity of the target muscles in 20 healthy adults (10 male, 10 female; aged 22–25). Root mean squared values for mean maximum and average percent activation normalized to maximum voluntary isometric …

Building A Meditation Room To Improve Critical Care Nurse’S Work Environment: An Evidence-Based Practice Project, Jennifer Alonso, Daphne Pierre, Stephanie Wald, Stephen Breazeale

Nursing & Health Sciences Research Journal

Background: Burnout, stress, and compassion fatigue are common among nurses, especially for those working in intensive care and during night shifts, and may contribute to the global nursing shortage. Thus, nursing organizations have issued recommendations to improve workplace health. Aligned with these initiatives, we sought to improve nurses' stress by creating a meditation room in the intensive care unit at a hospital in Miami. Methods: This evidence-based practice project took place from March to August 2023. The meditation room opened in May 2023 with a variety of therapeutic modalities, including meditation, music, and aromatherapy. We conducted two custom-designed surveys to …

Exploring Intensive Care Registered Nurses’ Perceptions Of The Family Support Person During Family-Witnessed Resuscitation, Carmen Petersen, Martha O. Morales, Natalie Bermudez

Nursing & Health Sciences Research Journal

Background: In-hospital cardiac arrests are common occurrences that family members may be present for. Family-witnessed resuscitation (FWR) is a well-studied, evidence-based practice with positive outcomes for family members. However, some nurses disagree with FWR because of the potential for family member disruptions. The presence of a hospital-employed family support person (FSP) dedicated to providing care to family members during FWR may be beneficial in improving nurses’ perspectives on FWR. While evidence shows the benefits of the FSP for family members during FWR, there is little evidence related to nurses’ perceptions of the FSP. Therefore, the purpose of this qualitative descriptive …

Addressing End-Of-Life Care Education Gaps For Registered Nurses: A Quality Improvement Project, Mayra Villalba, Alejandra Angel, Arvinder Singh

Nursing & Health Sciences Research Journal

Background: As the global elderly population grows rapidly, end-of-life care (EOLC) needs have expanded, warranting comprehensive nursing education. There is a significant gap in exposure to EOLC during nursing undergraduate education, clinical experiences, and training opportunities in the professional setting. The purpose of this quality improvement project was to educate nurses about end-of-life care. Methods: In an established medical-surgical unit, hospice patients with comfort-only measures were placed into a cohort labeled Transitional Care Unit (TCU). Between October 2023 and May 2024, nurses working in the TCU were surveyed on their knowledge regarding EOLC. Staff attended mandatory education sessions after the …

Impact Of An Interdisciplinary Team On Patients Seen At A Heart Failure Clinic, Nilda Pelegrino, Faaria Quadri, Elaina Rosario, Jacqualine Igwe, Sandra Chaparro, Lourdes Labrada, Sara Panella, Maria Pulido, Stephen Breazeale, Zhenwei Zhang

Nursing & Health Sciences Research Journal

Background: Heart failure is a complex clinical syndrome that requires the involvement of interdisciplinary teams to address patient needs and optimize therapy. Interdisciplinary teams, including physicians, advanced practice practitioners, and pharmacists, play a crucial role in implementing guideline-directed medical therapy and addressing barriers to self-care that ultimately improve patients’ overall survival. This study assessed the impact of an interdisciplinary team on patients’ heart failure outcomes compared to patients solely managed by clinical cardiologists. Methods: This was a single-center retrospective chart review study of Baptist Health patients seen at the heart failure clinic. The study compared patients seen by an interdisciplinary …

Beyond “C”: A Nurse Navigator-Led Education Project To Increase Survivorship Referrals And Cancer Survivorship Attendance, Carem Irma Costa Castro, Morgan Nestingen, Tania Silva Santos, Pamela Delongchamp, Luz Morales, Barbara Quintana, Marguerite Rowell, Merly Alonso, Natalie Bermudez

Nursing & Health Sciences Research Journal

Introduction: Recent advancements in cancer care have improved the prognosis of many cancer survivors who are living longer due to early detection and improvements in treatment. These survivors remain at risk for long-term physical treatment side effects. Survivors may also experience depression and anxiety related to fear of recurrence. Studies show many benefits for patients who participate in survivorship programs; however, participation remains low due to various barriers. The purpose of this evidence-based practice project was to implement an oncology nurse navigator (ONN)-led survivorship patient education initiative and evaluate its effectiveness on survivorship program referrals and participation. Methods: Baptist Health’s …

Letter From The Editor: Nurse Scientists At Baptist Health, Nohemi Sadule Rios

Nursing & Health Sciences Research Journal

No abstract provided.

Nurse-Led Advocacy In Reducing 30-Day Readmission Rates For Heart Failure Patients With Reduced Ejection Fraction, Lourdes M. Talavera, Madeleine Turco, Hector Gonzalez, Catherina Chang Martinez, Daniela Wintersteen, Stephanie Villadamigo, Alexandra Palau, Maria L. Perez, Cindy Delgado, Stephani Cardona, Christina Davis, Gustavo Ramirez, Marta Larranaga, Betty Muniz, Jessica G. Bundy

Nursing & Health Sciences Research Journal

Background: Heart failure with reduced ejection fraction (HFrEF) is associated with increased mortality, morbidity, and readmission rates. Evidence-based practice outlines that HFrEF patients should be on guideline-directed medical therapy (GDMT), including medication from four categories: renin-angiotensin system inhibitors, β-blockers approved for the treatment of heart failure, aldosterone antagonists, and sodium-glucose cotransporter 2 inhibitors. Nurse-led patient advocacy for patients to be discharged on GDMT can help reduce 30-day readmission rates in patients with HFrEF in an inpatient heart failure unit. The purpose of this project was to implement a new practice involving the utilization of a discharge form and empowering nurses …

Implementing And Assessing Climate Change Education In A Pediatrics Residency Curriculum, Mark Mcshane, Shelley Kumar, Linessa Zuniga

Center for Medical Ethics and Health Policy Staff Publications

Background For physicians to effectively combat the growing health crisis that is climate change, they should begin learning during medical training about its health implications. However, there is little data on residents' knowledge of the climate crisis, and even less data regarding the effectiveness and acceptability of climate change education in graduate medical training programs. Objective To incorporate a new educational session on the health implications of climate change into a residency curriculum and evaluate the acceptability of the session and its effects on residents' knowledge, attitudes, and perceptions of the topic.

Methods In July 2021, a 90-minute, interactive, small-group …

Challenging A Sacred Cow: Implementing Clear Liquids During Labor, Paloma Casemeiro, Carey B. Acosta, Judith E. Bowling

Nursing & Health Sciences Research Journal

Background: Traditionally, patients in labor could not have anything to eat or drink (nothing by mouth [NPO]) due to long-standing beliefs, often labeled "sacred cows." However, recent research indicated that clear liquids during labor can be safe and beneficial. Methods: Prior to implementing this project, the team collected information from 20 low-risk laboring mothers regarding their satisfaction level and their perception of the overall childbirth experience. Clear liquids were permitted for low-risk mothers and data were collected from the same population to evaluate the impact on their labor experience. The primary goal of this project was to challenge the “sacred …

Improving Mobility In Acute Care Patients With A Mobility Technician: A Quality Improvement Pilot Project, Oscar A. Acosta, Erin Shea, Madelyn Lliteras, Mary B. Gomes, Tiffany D. Baker, Catherina Chang Martinez

Nursing & Health Sciences Research Journal

Background: Early mobilization during hospitalization remains an important element in the patient’s recovery and is associated with good clinical outcomes. Despite these benefits, nurses and physical therapists experience challenges from time constraints and competing responsibilities. Mobility technicians present an alternative for safe and early patient mobilization during hospitalization. Methods: The purpose of this quality improvement project was to implement a mobility technician program to improve patients’ mobility during their hospital stay. The setting was a medical-surgical nursing unit of a hospital in South Florida. A protocol was implemented in December 2023. Patients who met the criteria for ambulation using the …

Exploring Relationships And Predictors Of Job Embeddedness And Intent To Stay In Acute Care Registered Nurses, Nada Wakim, Myriam Bigaud-Ambroise, Laurie Cogar, Natalie Bermudez

Nursing & Health Sciences Research Journal

Background: Registered nurse turnover is an enduring, ubiquitous global concern exacerbated by the COVID-19 pandemic. An estimated 13 million worldwide nursing shortage is projected with increased domestic U.S. 2021 turnover and vacancy rates. Examining phenomena, such as job embeddedness (JE), may provide further insight into nurses’ multifaceted reasons for remaining in a position. Evidence shows that nurse-leader influence and nurses’ financial situations are also factors associated with JE and intent to stay (ITS). Therefore, the purpose of this study was to explore the relationships and predictors between nurse participants’ characteristics (including direct nurse leader [DNL] influence, familial financial contribution [FFC], …