Medicine and Health Sciences Commons^™

Pregnancy Outcomes After Covid-19 Infection, Angela M. Blanco Guertin, Arvinder Singh, Arianna Tapia, Emily Dickinson

Nursing & Health Sciences Research Journal

Background: Since the onset of the Coronavirus 19 (COVID-19) pandemic in 2020, the medical community has raced to keep up with the continued healthcare sequelae of the virus. During this time, pregnant women and newborns have been of particular concern. A higher incidence of pregnancy-related complications was seen among women during the pandemic. This study aimed to assess the relationship between COVID-19 and pregnancy complications among women. Methods: This retrospective study analyzed records of pregnant women with active COVID-19 or a history of COVID-19 during pregnancy, admitted to a South Florida hospital between March 2020 and December 2021. Patients’ charts …

Impact Of Human Immunoglobulin Genetic Variants On The Expressed Antibody Repertoire., Eric Engelbrecht

Electronic Theses and Dissertations

B cells produce immunoglobulins (IGs; antibodies), which are critical protein components of the immune system. Human IGs are composed of two pairs of identical ‘heavy’ chains and ‘light’ kappa or lambda chains, encoded by genes located at three loci in the genome: the IG heavy chain locus (IGH, chromosome 14), and the IG lambda (IGL, chromosome 22) and kappa (IGK, chromosome 2) loci. Each locus spans ~920-100 kilobase pairs (Kbp) of DNA and harbors families of gene segments that are somatically rearranged during B cell development. The IG loci collectively harbor >180 functional genes, many of which are part of …

Pharmacist-Led Care In Collaboration With A Cardiovascular Team To Improve The Management Of Atherosclerotic Cardiovascular Disease Risk In Hospitalized Patients, Dayana Martinez, Radhan B. Gopalani, Kristen De Almeida, Maura Falli, Lisa K. Davis, Jody Murray, Adedapo Iluyomade, Tarak S. Rambhatla, Jonathan Fialkow

Nursing & Health Sciences Research Journal

Background: Cardiovascular disease (CVD) is the leading cause of death worldwide, affecting approximately 17.5 million people yearly. In high-risk patients, reducing lipids, decreasing blood pressure, and ceasing smoking have been shown to lower primary and secondary CVD risk. This project aims to evaluate the impact of pharmacist-led care by identifying and managing atherosclerotic cardiovascular disease risk and further optimizing guideline-directed medical treatment (GDMT) in hospitalized patients with coronary artery disease (CAD). Methods: This biphasic quality improvement project was conducted at a community hospital. Patients aged 18 or older with acute coronary syndrome or undergoing elective cardiac catheterization were included. Patients …

Examining Anxiety And Coping Strategies With Persons With Parkinson's Disease (Pwpd) Who Routinely Exercise, Ashlynn Milburn, Angela Labrie Blackwell, Karen Aranha, Maggie Abbott

Fall 2024 OTD Capstone Symposium

Forty to 50% of the PwPD are reported to experience anxiety (Kwok et al., 2019). Anxiety is psychological distress characterized by excessive worry, and apprehension about future events (Khatri et al., 2020). Psychological distress with this population is secondary to care dependency, poor work and social function, increased physical and cognitive decline, increased dementia risk, and high mortality rate (Kwok et al., 2019).Exercise and meditation have been found to be useful coping strategies to manage one’s physical condition as well as psychosocial factors such as anxiety, with PD (Mantri et al., 2021).Although these coping strategies have the potential to reduce …

Benefits Of Occupational Therapy In Concussion Treatment For Professional Athletes, Alexandria Brown, Zeida Gutierrez Ph.D., Mhs, Otr/L, James Wersal Otd, Msot, Otr/L, Cbis, Drs, Dcs

Fall 2024 OTD Capstone Symposium

Concussions are a significant concern in sports, with an estimated 1.6 to 3.8 million cases in the U.S. annually, many of which go unreported. These traumatic brain injuries result from various impacts, causing symptoms like headaches, dizziness, and memory loss, which can disrupt an athlete's daily life. Recovery typically follows a staged protocol, with professional organizations implementing concussion management guidelines. Despite these measures, athletes often hesitate to report symptoms due to concerns about playing time or team expectations. There is a gap in treatment for concussions as activities of daily living and occupations are not addressed. Occupational therapy can help …

Preventing Depression In Grandparents Raising Grandchildren: An Educational Video Series, Sabrina Casares, Steven Gerardi, Meghan Skidmore

Fall 2024 OTD Capstone Symposium

Grandparent caregivers often face increased risk for depression, yet access to mental health resources—particularly self-help approaches—is limited. Texas Grandparents Raising Grandchildren (TXGRG), a non-profit organization supporting grandparent caregivers, lacked a specific mental health resource to address this need. This capstone project developed and implemented a self-help, occupation-based educational video series to provide practical strategies for preventing and managing depression. Designed for accessibility and ease of use, the video series offers tools grounded in daily occupations to promote mental well-being. This project fills a critical gap by equipping TXGRG and its caregivers with a proactive, occupation-focused mental health resource to support …

Life Review And Reminiscence In Occupational Therapy Practice: An Educational Video Series, Andrea Garza, Steven M. Gerardi Phd, Otd, Mss, Otr

Fall 2024 OTD Capstone Symposium

Dementia is a progressive neurological disorder that impacts millions of people, leading to cognitive decline and functional impairment. Life review therapy and reminiscence therapy are effective treatment approaches that have been used with people with dementia to stimulate cognitive processes and provide emotional support by reflecting on past experiences. Although therapeutic occupations based on reminiscence and life review have been used in occupational therapy (OT) practice, there is limited literature on the topic to guide clinical practice. Problem: There is a lack of guidance on the integration of occupation-based life review and reminiscence into OT practice for people with dementia. …

Cuisine As A Compass: Exploring The Therapeutic Benefits Of Community, Cooking, And More Within The Lgbtqia+ Population, Sera Shevchenko, Karen Park Otd, Otr/L, Bcp, Susan Macdermott Otd, Otr/L

Fall 2024 OTD Capstone Symposium

Background: The LGBTQIA+ population experiences unique barriers to occupation and well being. Anti-LGBTQ legislation encroaches on inclusive and affirming care affecting occupational access. Limited occupational participation and additional exhaustive adaptive strategies to engage in occupations safely have an emotional cost. This research study explores how food or mealtime occupations such as cooking, eating, and hosting can support LGBTQIA+ well-being. This research was made possible by LGBTQIA+ participants that are experts of their lived experience.

Methods: This mixed methods research used both qualitative and quantitative methods to gather data on the significance of food-based occupations, culture, mental health, and identity in …

Increasing Teacher-Ot Collaboration In A School-Based Setting, Shayla Ransome, L. Brook Sawyer, Angela Labrie Blackwell

Fall 2024 OTD Capstone Symposium

Pre-service PreK-4 teachers receive little to no education about SBOT practice, which hinders not only collaboration opportunities but also potentially impacts student performance and participation outcomes negatively. This capstone seeks to develop an interprofessional educational unit to increase collaboration between pre-service PreK-4 teachers and pre-OT practitioners, which will promote positive student performance and participation outcomes.

Neurodivergent Adults: Cultivating Intimate Partner Relationships Through Diverse Dating Platforms To Improve Well-Being And Life Satisfaction, Victoria R. Wolf, Mary Jan Greer

Fall 2024 OTD Capstone Symposium

This capstone project focuses on program development to increase the social participation of neurodivergent adults in establishing intimate partner relationships (AOTA, 2020). Creating an opportunity for neurodivergent individuals to meet each other with the intent of forming intimate partner relationships can increase their social participation and overall life satisfaction (Mitran, 2022). According to AOTA (2020), intimate partner relationships are essential to many individuals' lives. Altering the modern-day approach and building online and in-person platforms that support the individuality of the neurodivergent population will enable them to form connections without prejudice or judgment (Mitran, 2022).

Adapting Classroom Activities To Increase Social Engagement, Ivie Hacker, Mary Jan Greer Ph.D., Otr

Fall 2024 OTD Capstone Symposium

This capstone program focuses on enhancing the development of children with disabilities through adaptive play strategies. It aims to create a supportive, engaging environment that accommodates the unique needs of children on the autism spectrum. By incorporating individualized play techniques, the program promotes social, emotional, and cognitive skills, fostering greater communication, creativity, and physical coordination. The project explores the role of adaptive play in improving social interactions, reducing sensory sensitivities, and building self-confidence, ultimately contributing to the overall well-being and development of children with autism.

Sex Education Program For Individuals With Disabilities, Kalynne Coates, Keisa Boykin

Fall 2024 OTD Capstone Symposium

The purpose of this project is to develop and implement a program to discuss the ADL of sex education with individuals with intellectual and developmental disabilities (IDD).

Tocilizumab In The Management Of Neuromyelitis Optica Spectrum Disorder: A Narrative Review Of Literature And Critical Appraisal, Salman Mansoor, Samar Iltaf Mairajuddin, Saqib Gul

Pakistan Journal of Neurological Sciences (PJNS)

Background and objective

Neuromyelitis Optica Spectrum disorder (NMOSD) mostly affects the spinal cord and optic nerves. This manuscript aims to explore the treatment potential of tocilizumab, a monoclonal antibody that targets the interleukin-6 (IL-6) receptor and regulates inflammatory cytokines implicated in the pathophysiology of NMOSD. Methods

A thorough search of the pertinent literature was done for this research utilising electronic databases, specifically PubMed, Cochrane Library, and Embase, which contained studies published from 2016 to 2024.

Results Clinical studies show that tocilizumab improves clinical outcomes and lowers recurrence rates in people with NMOSD, especially those who don't respond to traditional treatments. …

Chorea As A Rare Manifestation Of Neuropsychiatric Systemic Lupus Erythematosus: A Case Report, Qurat Ul Ain, Ashfeen Ishfaq, Farzana Kouser, Rabia Rasool

Pakistan Journal of Neurological Sciences (PJNS)

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multisystemic involvement. It has variable clinical presentations and a relapsing and remitting course. Clinical manifestations are broad, ranging from mild mucocutaneous involvement to major organ involvement. We present a case of a 32-year-old female with repeated movements of the right arm, and confusion with a background of pains in multiple joints. She was diagnosed as a case of Neuropsychiatric Systemic Lupus Erythematosus (NPSLE). She was managed with pulse therapy of cyclophosphamide (CYC) along with other supportive medications. After six months of intensive immunosuppressive therapy, she remained well and continued maintenance …

A Sticky Mess—Are Moisturizers Overused In Dermatitis Care?, Susan Nedorost

Faculty Scholarship

Microbial dysbiosis is increasingly understood to influence allergic sensitization and skin barrier defects in dermatitis. Occlusion, such as from moisturizers, fosters microbial dysbiosis, and increases itch in many patients with dermatitis. Nevertheless, use of moisturizers in dermatitis remains part of dermatologic guidelines. This is a review of the evidence of benefits and adverse effects of moisturizers in dermatitis and a proposal for moderation in their clinical use.

Volunteering For Medically Underserved Children: Clinic With A Heart–Back-To-School Clinics, Isabella Marie Kerby Kessinger

Honors Program: Senior Projects (Public)

Medically underserved children, often from low-income families or areas with limited healthcare resources, face significant barriers in accessing essential medical services and represent a fundamental challenge to equity and social justice. School physicals and back-to-school clinics play a crucial role in addressing these healthcare needs, serving as a gateway to educational and extracurricular opportunities.

Clinic With a Heart (CWH), a non-profit medical and dental clinic in Lincoln, Nebraska, serves as a model for addressing healthcare disparities. In 2023, CWH provided 3,109 visits to 1,846 unique patients, with 83% lacking health insurance and 63% having household incomes below $16,000 annually. The …

Examining Factors Of Variance In Energy Metabolism Of Dairy Cattle, Addison Lee Carroll

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Variation is thought to occur in the use of dietary energy for production in dairy cattle. First, variance can be observed when new methane mitigation strategies are fed resulting in increased H₂ output potentially resulting in downstream effects on estimates heat production via the Brouwer (1965) equation. Therefore, in chapter 3 a review was created to systematically describe the mathematics and theory behind the Brouwer equation, and rederive a heat production equation to integrate H₂ production. Results indicate heat production using the classical Brouwer equation (1965) relative to the rederived equation resulted in an overestimation of heat production …

Microbiome Variation In Production Phenotypes And The Role Of Colonization History In Microbiome Establishment, Seidu Adams

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Ruminant-based agriculture is expected to continue to be a major contributor to food security to feed the growing population. At the heart of nutrient degradation of complex organic matter within the rumen are its microbes. These microbes can convert otherwise unusable organic matter into usable protein and energy and can provide up to 50% of the animal’s protein needs and up to 70% of the energy needs. The microbial functional capacity within the rumen determines the nutrients utilized and the end products of fermentation. However, our understanding of microbial functional capacity within the rumen and factors that influence the rumen …

Investing In Limb Preservation: A Case Report In Avoiding Bilateral Amputation In A Vasculopathy Patient, Nikita Gambhir, Heather V. Tran, Craig J. Verdin, Stephanie N. Campbell, Cyaandi Dove

School of Podiatric Medicine Publications

Limb salvage and prosthetics play vital roles in restoring function and mobility for patients with severe injuries or metabolic conditions. Limb salvage involves surgical techniques aimed at preserving a limb rather than resorting to amputation, while prosthetics provide artificial devices to replace lost limbs. Key considerations for limb salvage include restoring a functional foot, maintaining patient independence, minimizing hospitalizations, and avoiding bilateral lower limb amputations. Aggressive measures in wound care and surgery are needed for patients already at single-limb status with PAD and coronary artery disease (CAD).

The Effects Of Mosaicism On Biological And Clinical Markers Of Alzheimer's Disease In Adults With Down Syndrome, Laura Xicota, Lam-Ha T. Dang, Alice Lee, Sharon Krinsky-Mchale, Deborah Pang, Lisa Melilli, Sid E. O’Bryant, Rachel L. Henson, Charles Laymon, Florence Lai, H. Diana Rosas, Beau Ances, Ira Lott, Christy Hom, Bradley Christian, Sigan Hartley, Shahid Zaman, Elizabeth Head, Mark Mapstone, Zhezhen Jin, Wayne Silverman, Nicole Schupf, Benjamin Handen, Joseph H. Lee, Alzheimer’S Biomarker Consortium – Down Syndrome (Abc-Ds)

Neurology Faculty Publications

Background Individuals with Down syndrome (DS) are at high risk of early-onset Alzheimer’s disease (AD); yet, some 20 percent do not develop any signs of dementia until after 65 years or in their lifetime. Mosaicism could contribute to this phenotypic variation, where some disomic cells could lead to lower levels of gene products from chromosome 21.

Methods We examined longitudinal neuropsychological and biomarker data from two large studies of DS: the Alzheimer Biomarker Consortium–Down syndrome study (ABC-DS) (n = 357); and a legacy study (n = 468). We assessed mosaicism using karyotyping or GWAS data. Participants had data on plasma …

Targeted Long-Read Sequencing To Quantify Methylation Of The C9orf72 Repeat Expansion, Evan Udine, Nicole Finch, Mariely Dejesus-Hernandez, Jazmyne L. Jackson, Matthew C. Baker, Siva Arumugam Saravanaperumal, Eric Wieben, Mark T. W. Ebbert, Jaimin Shah, Leonard Petrucelli, Rosa Rademakers, Björn Oskarsson, Marka Van Blitterswijk

Neurology Faculty Publications

Background The gene C9orf72 harbors a non-coding hexanucleotide repeat expansion known to cause amyotrophic lateral sclerosis and frontotemporal dementia. While previous studies have estimated the length of this repeat expansion in multiple tissues, technological limitations have impeded researchers from exploring additional features, such as methylation levels.

Methods We aimed to characterize C9orf72 repeat expansions using a targeted, amplification-free long-read sequencing method. Our primary goal was to determine the presence and subsequent quantification of observed methylation in the C9orf72 repeat expansion. In addition, we measured the repeat length and purity of the expansion. To do this, we sequenced DNA extracted from …

Ex-Vivo Evaluation Of Clinically-Set Hydraulic Sealers Used With Di!Erent Canal Dryness Protocols And Obturation Techniques: A Randomized Clinical Trial, Shehabeldin Mohamed Saber Prof.Dr.

Dentistry

Objectives This 2-part randomized parallel triple-blind clinical trial adopts a unique model assessing clinically-set hydraulic

calcium silicate-based sealers (HCSBS) after different root canal dryness protocols and obturation techniques.

Methods For the first phase of the study, 24 teeth scheduled for orthodontic extractions were allocated into four groups

according to the canal dryness protocol and the obturation technique. G1 (CLC-AHP): cold lateral compaction (CLC) with

AH Plus sealer, G2 (CLC-ES-SD): CLC with Endosequence (ES) after standard canal(s) dryness (SD); G3 (SC-ES-SD):

matching single-cone (SC) with ES after SD; G4 (SC-ES-PD): as G3 but after partial canal(s) dryness (PD). Teeth were

extracted …

An Innovative Community‐Led Education And Recruitment Program To Increase Clinical Research Participation Among Black Americans, Bahar Niknejad, Ethlyn Mcqueen Gibson, Travonia Brown-Hughes, Katie Mcdonough, Ebony Andrews, Deborah Hudson, Hamid Okhravi

Glennan Center for Geriatrics and Gerontology Faculty Publications

Background: Previous studies attest to a lack of awareness about Alzheimer’s Disease (AD) and limited participation of Black Americans in AD clinical trials. The AHEAD Study is a multicenter trial focused on preventing AD by evaluating the effectiveness and safety of Lecanemab in individuals with preclinical AD. The study aims to recruit at least 15% from underrepresented populations, including Black Americans. To achieve this goal, our study site utilizes a community-based participatory research (CBPR) approach and developed a Community Education and Recruitment Program (CERP) designed to increase the participation of Black individuals in the AHEAD Study.

Method: In a collaborative …

Understanding And Intervening In Children's Tick Risk Perceptions And Protective Behaviors: A Grounded Theory, Ariel Dawdy

Department of Entomology: Dissertations, Theses, and Student Research

Children, ages 8 years and younger, are at a particularly high risk of contracting a tick-borne disease. This is partially due to the misconceptions spread about tick protective behavior and a poor understanding of how antibiotic treatment can help. Because most communities and families believe that tick control is the individual’s responsibility, looking at the interaction between ticks and human children is essential to understanding the individual’s motivations to protect themselves. To help alleviate the number of individuals contracting tick-borne diseases, misconceptions must be addressed, intervention programs implemented, and a behavioral change must occur. This study used a qualitative research …

Analysis Of Impulsive Differential Equation Models Of Cell Populations Undergoing Radiation Therapy, Abigail D'Ovidio Long

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Radiation therapy is a mode of treatment which is implemented for approximately 50% of cancer patients. Treatment needs to be able to kill cancer cells, but also do minimal damage to surrounding healthy tissue. We propose two main impulsive differential equation models of radiation therapy to capture the periodic nature of the treatment. These models build off of previous studies using clinical data to ensure biological relevance. The first model incorporates only cancer cell populations, and we provide parameter relationships which theoretically ensure treatment outcomes of cancer eradication, cancer approaching a carrying capacity, and cancer approaching a periodic solution. We …

Taking A Closer Look At Tpack: Examining Teacher Perspectives Of The Knowledge, Competencies, And Context Needed For Improved Remote Education In Grades 4-8, Jennifer Christine Buth Bell

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Though wrought with challenges, the COVID-19 Pandemic, which led to the closure of schools worldwide and forced educators into a rapid transition from traditional to Emergency Remote Teaching (ERT), held some promise for furthering the integration of digital technology in schools. But now, years following the crisis, policymakers, administrators, and teachers continue to grapple with how best to incorporate lessons learned and improve the future of teaching and learning in both traditional and remote settings. This mixed-methods study (n = 21; n = 6) followed an explanatory sequential design to collect and analyze data from a sample of 4th-8th …

Novel Mouse Models To Study The Role Of T Cells In Cardiac Autoimmunity, Meghna Sur

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Myocarditis patients can chronically develop dilated cardiomyopathy and autoreactive T cells could contribute to the disease pathogenesis, but defining their antigen specificity remains a major challenge. To fill this gap, we generated T cell receptor (TCR) transgenic (Tg) mice specific to cardiac myosin heavy chain (Myhc)-α 334–352 and made a few observations. First, we unexpectedly noted both CD4 and CD8 T cells expressing TCRs specific to Myhc-α 334–352. Second, while Tg T cells from myocarditis-resistant C57BL/6J mice did not respond to Myhc-α 334–352, those from immunized mice responded, indicating that in vivo priming is necessary to break tolerance. Third, upon …

Enhancement Of Zika Virus Infection By West Nile And Dengue Virus Antibody Positive Cord-Blood Samples From Mothers In El Paso-Texas, Jeanette Orbegozo

Open Access Theses & Dissertations

The recent Zika virus (ZIKV) outbreak and its association with microcephaly cases and other neurological syndromes are important public health concerns. A phenomenon known as antibody-dependent enhancement (ADE) involves preexisting flavivirus antibodies to a specific flavivirus that enhances the severity of a second infection with a different flavivirus. Since ZIKV is related to flaviviruses like West Nile virus (WNV) and dengue virus (DENV), prior exposure to these viruses could elicit cross-reactive antibodies that may enhance a subsequent ZIKV infection. Therefore, this study aimed to determine if WNV and DENV antibodies from cord blood enhanced ZIKV infection in vitro. Initially, a …

Novel Therapuetic Approaches For Chagas Disease, Juan Carlos Silva

Open Access Theses & Dissertations

Chagas disease (CD) is caused by the hemoflagellate protozoan Trypanosoma cruzi. This disease is considered one of the 20 neglected tropical diseases (NTD), and it is estimated that 6 to 8 million people worldwide are diagnosed with CD. In the United States, Chagas infection is not reported in all states; however, most reported CD cases are chronic infections. Chagas infection is characterized by two phases: an acute and a chronic phase. Until this present moment, no prophylactic or therapeutic human vaccine is available. However, in a recent study in a murine model, our group showed that the synthetic 20-merpeptide (DAENPGGEVFNDNKKGLSRV) …

Assessing Sedimentation Impact Through Dem, Point Cloud, And Discharge Analysis, Shandell Thomas

Open Access Theses & Dissertations

This study focused on five arroyos flowing into the Rio Grande, in the stretch between Caballo Dam and Las Cruces, New Mexico. Drone imagery was acquired from study areas in each arroyo. Photogrammetry was used to create high-resolution digital elevation models (DEMs), point clouds, drone imagery and potential discharges were acquired for each arroyo. Investigation of seven different methods resulted in the selection of the Terrain Ruggedness Map (TRM) as a predictor of surface roughness, along with high-resolution DEMâ??s to illustrate small and low-relief channel features. The five arroyos with varying sediment sizes and characteristics were studied to understand how …