Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences Commons™

Open Access. Powered by Scholars. Published by Universities.®

2024

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 1201 - 1230 of 27154

Full-Text Articles in Medicine and Health Sciences

Determining An Optimal Case Definition Using Mid-Upper Arm Circumference With Or Without Weight For Age To Identify Childhood Wasting In The Philippines, Lyle Daryll Dimaano Casas, Jhanna Uy, Eldridge Ferrer, Charmaine Duante, Paluku Bahwere, Rene Gerard Galera, Alice Nkoroi, Behzad Noubary, Mueni Mutunga, Sanele Nkomani, Roland Kupka, Valerie Gilbert Ulep Dec 2024

Determining An Optimal Case Definition Using Mid-Upper Arm Circumference With Or Without Weight For Age To Identify Childhood Wasting In The Philippines, Lyle Daryll Dimaano Casas, Jhanna Uy, Eldridge Ferrer, Charmaine Duante, Paluku Bahwere, Rene Gerard Galera, Alice Nkoroi, Behzad Noubary, Mueni Mutunga, Sanele Nkomani, Roland Kupka, Valerie Gilbert Ulep

Health Sciences Faculty Publications

In resource-limited areas, where accurate weight-for-height Z-scores are hard to obtain, Mid-Upper Arm Circumference (MUAC) is a simple tool to identify wasted children. MUAC alone, however, may miss identification of many wasted children, leading to untimely intervention and potentially death. Our study aimed to identify the best-performing case definition to detect wasting by Weight-for-Height z-scores (WHZ) in Filipino children aged 6-59 months. We analyzed the 2018-2019 Expanded National Nutrition Survey to assess the diagnostic performance of MUAC cutoffs and a case definition combining MUAC and weight-for-age z-score (WAZ) in identifying moderate and severe wasting compared to the WHZ criterion. The …


Population-Based Cross-Sectional Analysis Of Cannabis Use Among Kentucky Adults, 2020– 21, Sydney Shafer, Gunnar Kennedy, W. Jay Christian Dec 2024

Population-Based Cross-Sectional Analysis Of Cannabis Use Among Kentucky Adults, 2020– 21, Sydney Shafer, Gunnar Kennedy, W. Jay Christian

UK CARES Faculty Publications

Purpose We conducted this study to assess cannabis use rates in the state of Kentucky relative to socioeconomic, demographic, and geographic factors, as well as reasons for use and modes of use, before the legal medical marijuana market commences in 2025.

Methods We pooled Kentucky Behavioral Risk Factor Surveillance System (BRFSS) data for 2020–2021 and used weighted responses for all analyses. We estimated current cannabis use (at least once in the past 30 days), and heavy use (at least 20 of the past 30 days) prevalence rates for Appalachian, Delta, and Central geographic regions of Ken- tucky. We tabulated descriptive …


The Contributions Of Motor Skill Proficiency To Cognitive And Social Development In Early Childhood, Catherine M. Capio, Norman B. Mendoza, Rachel A. Jones, Rich S.W. Masters, Kerry Lee Dec 2024

The Contributions Of Motor Skill Proficiency To Cognitive And Social Development In Early Childhood, Catherine M. Capio, Norman B. Mendoza, Rachel A. Jones, Rich S.W. Masters, Kerry Lee

Health Sciences Faculty Publications

With limited evidence from intervention studies, causal relationships between motor competence and cognitive and social development have yet to be clearly established. In this research, we investigated whether a targeted training programme to improve fundamental movement skills (i.e., object control, locomotor) in young children would also lead to improvements in the cognitive (i.e., executive function) and social (i.e., socioemotional competence) domains. Using a two-arm group randomised intervention design, 185 children aged 36 to 60 months (mean 47.51, SD 8.11 months) were allocated to a motor skill intervention group or an active control group. The intervention was implemented over one school …


Perceived Patient-Centered Care In Marching Band Artists, A L. Merrill, Z K. Winkelmann, N A. Uriegas Dec 2024

Perceived Patient-Centered Care In Marching Band Artists, A L. Merrill, Z K. Winkelmann, N A. Uriegas

Bakerman Student Research Awards

Objective: Approximately 27,000 college marching band (MB) artists in the United States could benefit from access to healthcare services and patient-centered clinicians. The purpose of this study was to explore HCPs MB artists have access to and their perceptions of patient-centered care (PCC). Methods: We used a cross-sectional web-based survey of MB artists (n=751, age=20±8 years). MB directors from 242 colleges were emailed a survey link to forward to MB artists. Participants indicated which HCPs they could access. Those who reported no access or unsure were prompted to describe what they would do if an injury or illness occurred. Participants …


Caregiver Involvement In Pediatric Speech-Language Pathology, Kathryn Ticknor Dec 2024

Caregiver Involvement In Pediatric Speech-Language Pathology, Kathryn Ticknor

Theses & Honors Papers

This study explores how caregivers and speech-language pathologists (SLPs) perceive caregiver involvement in pediatric speech therapy services. The research addresses how and when caregiver input is solicited, and to what extent the services children receive reflect caregivers’ expressed concerns and priorities. Using a two-phase survey design, caregivers and speech-language pathologists from private practices in Virginia provided quantitative responses on the importance, frequency, and effectiveness of collaboration. Overall, caregivers reported moderate levels of involvement (mean score: 3.88/5). Contrary to conventional wisdom, caregivers’ level of involvement was not directly correlated with their level of satisfaction, suggesting other factors, such as communication quality …


Academic Nurse Leaders’ Application Of Bolman And Deal’S Leadership Orientation Framework, Jasmine Bratton Dec 2024

Academic Nurse Leaders’ Application Of Bolman And Deal’S Leadership Orientation Framework, Jasmine Bratton

Dissertations

While Academic Nurse Leaders (ANLs) are vital to the functioning and quality of nursing programs in academic settings, many enter their roles with limited or no prior academic leadership and management experience. The inadequate preparation and development of ANLs remains a critical concern. For this reason, ANLs positions can be challenging and hard to fill. Although ANLs can hold various titles and positions across different academic institutions, this study specifically focuses on Deans, Directors, and Department Chairs working in the New York State area. Bolman and Deal’s (2021) four-frame model of leadership offers a framework that can be used to …


Evaluation Of Pain Control In Lobectomies: Before And After The Removal Of Liposomal Bupivacaine From Formulary At An Academic Health System, Kelly Cheng Pharmd, Michael Guerra Pharmd, Rebecca Pulk Pharmd, Ms, Bsp, Amber Zaniewski Pharmd, Mba, Bcps, Ryan Brown Pharmd, Bcps Dec 2024

Evaluation Of Pain Control In Lobectomies: Before And After The Removal Of Liposomal Bupivacaine From Formulary At An Academic Health System, Kelly Cheng Pharmd, Michael Guerra Pharmd, Rebecca Pulk Pharmd, Ms, Bsp, Amber Zaniewski Pharmd, Mba, Bcps, Ryan Brown Pharmd, Bcps

Posters

  • Liposomal bupivacaine is an extended-release formulation of the long-acting traditional local anesthetic, bupivacaine.
  • Yale New Haven Health system (YNHHS) removed liposomal bupivacaine from formulary in March 2024.
  • This decision was based on primary research and meta-analyses showing little to no clinical or statistical benefit of liposomal bupivacaine over traditional bupivacaine in morphine milligram equivalent use (MME) and median pain score in all surgeries including lobectomies.


Identifying Current Barriers And Optimization Opportunities Of Rapid Access Pathway To Outpatient Care For High-Cost Biologics In An Academic Health System, Avani Topiwala Pharmd, Vincent Do Pharmd, Bcps, Bctxp, Joseph Rosano Bs, Pharmd Dec 2024

Identifying Current Barriers And Optimization Opportunities Of Rapid Access Pathway To Outpatient Care For High-Cost Biologics In An Academic Health System, Avani Topiwala Pharmd, Vincent Do Pharmd, Bcps, Bctxp, Joseph Rosano Bs, Pharmd

Posters

  • Inpatient administration of specialty biologic agents can have significant financial impacts on a healthcare system.
  • The “Never Administer Inpatient List” (NAIL) is an established reference which contains biologic infusions that should be administered in an outpatient setting when clinically appropriate.
  • While outpatient administration may be clinically appropriate, there are many barriers to coordinating outpatient infusions that result in unnecessary inpatient administration. This can result in a prolonged length of stay and increased medication cost.


Host Response To Implantation Of A Poly N-Isopropylarylamide Injectable Cell Therapy Vehicle, Cole Matthew Burk Dec 2024

Host Response To Implantation Of A Poly N-Isopropylarylamide Injectable Cell Therapy Vehicle, Cole Matthew Burk

Master's Theses

There is a need to develop novel and effective therapies targeting end-stage peripheral arterial occlusive disease (PAOD). Inducing collateral arteriogenesis is a possible novel treatment that produces a natural bypass for blood flow, a promising solution to the long-term issues seen with current treatments. Regenerative therapies, and progenitor cells specifically, have demonstrated great promise in repair after injury and disease. While most progenitor or stem cells have poor efficacy in this context, muscle progenitor cells, or myoblasts, have encouraging results. Myoblasts enhance arteriogenesis and secrete cytokines or chemokines that recruit monocytes to injury sites. Implanting these adherent cells in a …


Safeguarding Virtual Healthcare: A Novel Attacker-Centric Model For Data Security And Privacy, Suvineetha Herath, Haywood Gelman, John Hastings, Yong Wang Dec 2024

Safeguarding Virtual Healthcare: A Novel Attacker-Centric Model For Data Security And Privacy, Suvineetha Herath, Haywood Gelman, John Hastings, Yong Wang

Research & Publications

The rapid growth of remote healthcare delivery has introduced significant security and privacy risks to protected health information (PHI). Analysis of a comprehensive healthcare security breach dataset covering 2009-2023 reveals their significant prevalence and impact. This study investigates the root causes of such security incidents and introduces the Attacker-Centric Approach (ACA), a novel threat model tailored to protect PHI. ACA addresses limitations in existing threat models and regulatory frameworks by adopting a holistic attacker-focused perspective, examining threats from the viewpoint of cyber adversaries, their motivations, tactics, and potential attack vectors. Leveraging established risk management frameworks, ACA provides a multi-layered approach …


December 2024: Region 10 Emerging Special Pathogen Treatment Center (Resptc) At Providence Sacred Heart Medical Center & Children’S Hospital, Providence - Special Pathogens Program Dec 2024

December 2024: Region 10 Emerging Special Pathogen Treatment Center (Resptc) At Providence Sacred Heart Medical Center & Children’S Hospital, Providence - Special Pathogens Program

Special Pathogens Newsletters

REGION 10 SPECIAL PATHOGENS NEWSLETTER


Early Referral For Eye Movement Desensitization And Reprocessing Therapy For Treatment Of Trauma-Induced Anxiety And Emotional Distress, Christa Jones Dec 2024

Early Referral For Eye Movement Desensitization And Reprocessing Therapy For Treatment Of Trauma-Induced Anxiety And Emotional Distress, Christa Jones

Doctoral Projects

Trauma, anxiety, and emotional distress are significant health concerns affecting millions globally and resulting in significant healthcare burdens. Despite the considerable efforts in addressing problems, most high-risk cases often go unidentified or unaddressed promptly. Besides standard trauma diagnosis, treatment, and management protocols, some patients often require specialized support. Recently, Eye Movement Desensitization and Reprocessing (EMDR) has emerged as a promising alternative for treating anxiety, trauma, and emotional distress conditions, yet many patients who are at high risk are often not identified early for referral. Additionally, many healthcare facilities, especially those in rural settings, fail to include appropriate screening tools.

This …


Point Of Care Ultrasound For Gastric Residual: An Objective Structured Clinical Examination, Brandon Quinn, Kaitlyn Gray Dec 2024

Point Of Care Ultrasound For Gastric Residual: An Objective Structured Clinical Examination, Brandon Quinn, Kaitlyn Gray

Doctoral Projects

Point of care ultrasound (POCUS) has become an invaluable tool in modern medical practice offering real-time diagnostic and procedural guidance for anesthesia providers. POCUS is a non-invasive assessment tool that gives anesthesia insight into a quantitative assessment of gastric residuals. Furthermore, POCUS assessments are useful in preventing anesthetic complications that can cause major morbidity and mortality such as aspiration pneumonia. Despite the growing relevance, formalized training on POCUS for assessing gastric residuals remains limited in many nurse anesthesia programs. The University of Southern Mississippi currently lacks a standardized curriculum for teaching student registered nurse anesthetists how to utilize gastric ultrasound …


Twitchview(C) Monitor Use For Quantitative Neuromuscular Monitoring: An Objective Structured Clinical Evaluation, Brady Brian, Lovel Bruney Dec 2024

Twitchview(C) Monitor Use For Quantitative Neuromuscular Monitoring: An Objective Structured Clinical Evaluation, Brady Brian, Lovel Bruney

Doctoral Projects

Neuromuscular paralysis is an integral aspect of anesthesia. Muscle relaxation is implemented to provide a suitable surgical environment, aid in intubation, and enhance respiratory compliance (Cook & Simons, 2022). Neuromuscular monitoring is often used for patients undergoing general anesthesia. Proper neuromuscular monitoring is essential when managing a surgical patient undergoing general anesthesia. Anesthesia providers are responsible for knowing the theory behind neuromuscular monitoring and the appropriate execution of placement, monitoring, and interpretation of monitoring devices. Quantitative neuromuscular monitoring is a newer technology that can provide definitive numerical data regarding neuromuscular blockade. Implementing the quantitative neuromuscular monitor can potentially reduce the …


Reducing Congestive Heart Failure Readmissions Through Discharge Planning And Education, Coewonda Burse Dec 2024

Reducing Congestive Heart Failure Readmissions Through Discharge Planning And Education, Coewonda Burse

Doctoral Projects

Chronic heart failure (CHF) is a widespread problem among individuals, which, at the same time, consumes a considerable share of global healthcare demand. CHF management poses a persistent issue mainly due to the short interval of hospital readmissions four weeks after discharge, which indicates deficiencies in care transitions and patient education. This doctoral project addresses this topic and evaluates whether implementing patient-specific education and discharge planning programs can decrease CHF-associated hospital readmissions. To investigate the phenomenon, the DNP student completed a retrospective chart review, found an intervention, implemented said intervention, and then evaluated the intervention's effectiveness versus interventions already in …


Investigation Of Healthcare Providers' Receptiveness To Aromatherapy As An Adjunctive Intervention For The Postoperative Nausea And Vomiting In Gynecological Procedures, Hannah May, Lauren Sherrill Dec 2024

Investigation Of Healthcare Providers' Receptiveness To Aromatherapy As An Adjunctive Intervention For The Postoperative Nausea And Vomiting In Gynecological Procedures, Hannah May, Lauren Sherrill

Doctoral Projects

There is a knowledge deficit concerning healthcare providers' understanding of the use of aromatherapy as an intervention for postoperative nausea and vomiting (PONV) in clinical settings. Postoperative nausea and vomiting continues to exist despite using common pharmacological treatments to block receptors that stimulate the vomiting center (DiLustro, 2017). Postoperative nausea and vomiting leads to adverse effects that decrease patient satisfaction and prolong hospital stays. Healthcare providers need an adjunct therapy that minimizes risks and improves outcomes (Weibel et al., 2017). Through this project, provider understanding, and preferences were obtained and educational content delivered to potentially improve patient PONV outcomes. Using …


Prescription For Change: Tackling Inappropriate Antibiotic Use In Urgent Care Settings, Lachundra Mosley Dec 2024

Prescription For Change: Tackling Inappropriate Antibiotic Use In Urgent Care Settings, Lachundra Mosley

Doctoral Projects

A pressing global health issue that significantly contributes to antibiotic resistance is the inappropriate antibiotic prescribing for Upper Respiratory Infections (URI’s) in urgent care settings (World Health Organization [WHO], 2022). The purpose of this doctoral project was to reduce inappropriate antibiotic prescriptions for URI at an urgent care in D’Iberville, Mississippi through the implementation of an educational pamphlet.

A pre-post intervention project was conducted, collecting data on antibiotic prescribing practices via retrospective chart reviews before and after the educational intervention. Data was collected using a researcher developed screening tool based on Evidence based guidelines to distinguish viral vs bacterial infections. …


Investigating The Effects Of Workload Management Strategies On Nurse Practitioner Burnout And Job Satisfaction, Erica G. Smith Dec 2024

Investigating The Effects Of Workload Management Strategies On Nurse Practitioner Burnout And Job Satisfaction, Erica G. Smith

Doctoral Projects

Burnout is a critical issue among psychiatric mental health nurse practitioners (PMHNPs), worsened by excessive workloads, productivity demands, and the emotional intensity of patient care (Chi et al., 2024). The negative effects of burnout included diminished job satisfaction, reduced quality of care, and increased turnover (Chi et al., 2024). As the demand for Psychiatric Mental Health Nurse Practitioners (PMHNPs) grew, addressing these challenges was essential for maintaining a sustainable workforce and ensuring quality patient care.

This doctoral project aimed to assess the impact of a workload management strategy on reducing burnout and improving job satisfaction among PMHNPs in a hospital …


Improving Hypertension Outcomes Through Biweekly Text Message Interventions, Patricia Thompson Dec 2024

Improving Hypertension Outcomes Through Biweekly Text Message Interventions, Patricia Thompson

Doctoral Projects

Improving medication adherence and blood pressure control is challenging in the management of hypertension. Hypertension is a risk factor for severe health complications such as kidney failure, premature death, stroke, and heart disease. Even though effective hypertensive medications are available, patients have a challenging time adhering to taking the medication as instructed.

There are several reasons patients do not adhere to taking their medication such as lack of understanding, forgetfulness, negative beliefs, inadequate communication, complex dosing regimen, cost, and access to healthcare. Ensuring patients take their blood pressure medication decreases the risk of uncontrolled hypertension complications. The plan to improve …


Everyone Brings Something To The Table: A Culturally Sustaining Analysis Of Teacher Candidates’ Mixed Reality Teaching Simulations, Erin Scott Dec 2024

Everyone Brings Something To The Table: A Culturally Sustaining Analysis Of Teacher Candidates’ Mixed Reality Teaching Simulations, Erin Scott

Faculty Publications

Discussions of HBCU students’ content knowledge have centered around developing high impact, asset-based approaches to learning (Williams et al, 2022). So, HBCU teacher preparation providers (TPPs) can also focus efforts on culturally sustaining approaches to developing candidates’ content knowledge and researching how high impact practices, like teaching simulations, can help prepare candidates for classrooms. This exploratory case study uses critical cases (n=2); findings suggest candidates have a developing understanding of content, which forms a solid basis for increasing their knowledge. MRTSs are addressed as a potential high impact, culturally sustaining practice for building candidates’ content knowledge. Further, HBCU TPPs can …


The Impact Of Physical Exercise On Stress Reduction Among College Students, Natalie Luna Dec 2024

The Impact Of Physical Exercise On Stress Reduction Among College Students, Natalie Luna

Honors College Theses

Stress is a prevalent issue among college students, often contributing to mental healthchallenges such as anxiety and depression. While physical exercise is recognized as a beneficial strategyfor stress reduction, there is limited understanding of the specific exercise factors that influence stresslevels, including type, duration, and intensity. This study aimed to explore these factors, identify barriersand facilitators to regular exercise, and evaluate students' perceptions of physical exercise as a stressmanagement tool. Insights from this research aim to inform strategies for promoting physical activity toenhance student well-being.

A non-experimental, cross-sectional survey design was used to investigate the relationshipbetween exercise habits and stress …


Influences Of Social Media On Nutrition Perceptions And Body Image Among Female College Students: A Study Of Health Impacts And Behavioral Responses, Kerri Mcclanahan Dec 2024

Influences Of Social Media On Nutrition Perceptions And Body Image Among Female College Students: A Study Of Health Impacts And Behavioral Responses, Kerri Mcclanahan

Human Nutrition and Hospitality Management Undergraduate Honors Theses

Social media use is increasing among young adults with an average use of over four hours per day. The validity of dietary content on social media is questionable and can cause impacts on several factors. This research focused on exploring how female college students' social media use impacts their nutrition knowledge, diet choices, and body image. Through the use of a survey, 332 participants completed this research. It was found that social media can cause changes in body image, both positive and negative. Additionally, the results showed that social media impacted the participants’ dietary decisions. It was also found that …


Predictors Of Mystical Experiences In The Electronic Dance Music Scene, Cody Edward Lesniak Dec 2024

Predictors Of Mystical Experiences In The Electronic Dance Music Scene, Cody Edward Lesniak

All-Inclusive List of Electronic Theses and Dissertations

The present study examined the nature and frequency of reported mystical experiences within the Electronic Dance Music (EDM) scene and the roles psychedelic and psychedelic-like substances, set, and setting play in facilitating these experiences. Participants were recruited using posts on a variety of EDM-related Facebook groups (EDM, EDM Universal, EDM Festivals and Raves, etc.) and Reddit threads (bonaroo, electricdaisycarnival, RavesAndRavers, etc.). Participants completed a self-report survey consisting of questions pertaining to their involvement in the EDM scene, motives for attendance at EDM events, motives for drug use, importance of the values of peace, love, unity, and respect (PLUR), the proportion …


Brushing Up On Antibiotic Stewardship: Pharmacy Students Survey And Educate Dentists On Antibiotic Prescribing Guidelines And Practices, Niyaz Pordel, Kamaladdin Saei, Feifei Jia, Kaitlin Meyer, Lisa M. Avery Dec 2024

Brushing Up On Antibiotic Stewardship: Pharmacy Students Survey And Educate Dentists On Antibiotic Prescribing Guidelines And Practices, Niyaz Pordel, Kamaladdin Saei, Feifei Jia, Kaitlin Meyer, Lisa M. Avery

Doctoral External Publications

To evaluate dentists’ knowledge of ABX stewardship tools and to determine the likelihood of incorporating various antibiotic stewardship principles into practice after receiving a pharmacy school generated newsletter.


An Occupational Therapy Educational Guidebook For Participating In African American Hair Care, Kyra Mann, Lakeisa Boykin Dec 2024

An Occupational Therapy Educational Guidebook For Participating In African American Hair Care, Kyra Mann, Lakeisa Boykin

Fall 2024 OTD Capstone Symposium

This educational guidebook offers resources for occupational therapy practitioners (OTPs) to support African American hair care during Activity of Daily Living (ADL) interventions. The materials aim to enhance OTPs' awareness, knowledge, and confidence, fostering inclusive and effective approaches to improve participation and success in these tasks.


Understanding Ai Literacy: Implications For Practice, Sara Westall, Janet Anderson, Devon Olson Dec 2024

Understanding Ai Literacy: Implications For Practice, Sara Westall, Janet Anderson, Devon Olson

Librarian Publications

A presentation developed for the fall 2024 University of North Dakota School of Medicine and Health Sciences Medical Curriculum Advance, exploring the connections between information literacy, artificial intelligence literacy, and algorithmic literacy and their relevance to health education from the perspective of research and instruction librarians.


Crushability Analysis Of Immediate-Release Oral Tablets And Capsules Among Novel Fda Approvals In 2023, Kamaladdin Saei, Anne Schweighardt, Fang Zhao Dec 2024

Crushability Analysis Of Immediate-Release Oral Tablets And Capsules Among Novel Fda Approvals In 2023, Kamaladdin Saei, Anne Schweighardt, Fang Zhao

Doctoral External Publications

Many newly approved immediate-release (IR) solid oral drugs are accompanied by broad "do-not-crush" warnings, often without specific explanations. Building on our recent publication of crushability analysis of novel drugs approved between 2020 and 2022, this research extends the assessment to the approvals of 2023. Our goal is to provide healthcare providers with timely recommendations for the safe manipulation of immediate-release tablets and capsules for patients who cannot swallow them whole.


Investigating Impacts Of The Mycothiazole Chemotype As A Chemical Probe For The Study Of Mitochondrial Function And Aging., Naibedya Dutta, Joe A Gerke, Sofia F. Odron, Joseph D. Morris, Adam Hruby, Juri Kim, Toni Castro Torres, Sarah J. Shemtov, Jacqueline G. Clarke, Michelle C. Chang, Hooriya Shaghasi, Marissa N. Ray, Maxim Averbukh, Sally Hoang, Maria Oorloff, Athena Alcala, Matthew Vega, Hemal H Mehta, Max A Thorwald, Phillip Crews, Marc Vermulst, Gilberto Garcia, Tyler A. Johnson, Ryo Higuchi-Sanabria Dec 2024

Investigating Impacts Of The Mycothiazole Chemotype As A Chemical Probe For The Study Of Mitochondrial Function And Aging., Naibedya Dutta, Joe A Gerke, Sofia F. Odron, Joseph D. Morris, Adam Hruby, Juri Kim, Toni Castro Torres, Sarah J. Shemtov, Jacqueline G. Clarke, Michelle C. Chang, Hooriya Shaghasi, Marissa N. Ray, Maxim Averbukh, Sally Hoang, Maria Oorloff, Athena Alcala, Matthew Vega, Hemal H Mehta, Max A Thorwald, Phillip Crews, Marc Vermulst, Gilberto Garcia, Tyler A. Johnson, Ryo Higuchi-Sanabria

Natural Sciences and Mathematics | Faculty Scholarship

Small molecule inhibitors of the mitochondrial electron transport chain (ETC) hold significant promise to provide valuable insights to the field of mitochondrial research and aging biology. In this study, we investigated two molecules: mycothiazole (MTZ) - from the marine sponge C. mycofijiensis and its more stable semisynthetic analog 8-O-acetylmycothiazole (8-OAc) as potent and selective chemical probes based on their high efficiency to inhibit ETC complex I function. Similar to rotenone (Rote), MTZ, a newly employed ETC complex I inhibitor, exhibited higher cytotoxicity against cancer cell lines compared to certain non-cancer cell lines. Interestingly, 8-OAc demonstrated greater selectivity for cancer cells …


Improving Outcomes Of Patients Being Seen In The Emergency Room For Mental Health Crisis, Kimberly Hudson Dec 2024

Improving Outcomes Of Patients Being Seen In The Emergency Room For Mental Health Crisis, Kimberly Hudson

Doctoral Projects

Mental health is a significant problem, especially in males aged 20 to 50 years old (Omary, 2019). Lack of a primary mental health care provider, lack of proper treatment and follow up appointments for this population, and bottlenecking patients in the emergency room are all factors that contribute to the problem. As a result, these patients experience negative outcomes such as not receiving proper care and/or causing harm to themselves or others. In this doctoral project we will explore the option of patients having better outcomes if seen immediately by a psychiatric health care provider.

Having psychiatric healthcare providers in …


Elucidating The Mechanism Of Interleukin-17a Signaling In The Pathogenesis Of West Nile Virus, Farzana Nazneen Dec 2024

Elucidating The Mechanism Of Interleukin-17a Signaling In The Pathogenesis Of West Nile Virus, Farzana Nazneen

Dissertations

West Nile Virus (WNV), a neurotropic flavivirus transmitted by mosquitoes, is a leading cause of viral encephalitis in the United States and remains a significant public health concern. Unfortunately, no vaccine or therapeutic intervention is available against WNV infection. Previous studies, including ours, demonstrated that interleukin-17A (IL-17A) signaling increases the cytotoxic potential of CD8+ T cells to facilitate WNV and parasite clearance; however, the molecular mechanism is not understood. IL-17 receptor C (IL-17RC) is an obligatory co-receptor with IL-17 receptor A (IL-17RA) for signaling induced by IL-17A, IL-17A/F, and IL-17F. In this study, we found that IL-17RC deficient ( …