Medicine and Health Sciences Commons^™

Implicit Bias Mask 2023: Self-Awareness Of Actions Fosters Growth Mindset, Ankita Sai Satyavarapu, Ihunanya D. Agomuoh, Kaab Husain, Rachel Elizabeth Lycans, Rene Raul Andino-Galva, William Branden Burstein

Patient Education Projects

No abstract provided.

Implicit Bias Mask 2023: Dire Consequences Of Implicit Biases, Simran Salman Qureshi, Genevieve Murray, Jeswin David, Matthew Michael George, Raghav Rajesh, Ward D. Hedges

Patient Education Projects

No abstract provided.

Implicit Bias Mask 2023: Consider Past Experiences To Guide In Addressing Growth Mindset, Neha A. Iska, Amy Catherine Herrera, Eli Jarjous, Fatima Rizvi, Krishnan Shyamkumar, Preston Fong

Patient Education Projects

No abstract provided.

Implicit Bias Mask 2023: Promote Openness And Inclusiveness To Address Biases, Aneesh Sai Cherukuri, Ashlee V. Perry, Ethan Dewayne Dunn, Grace Victoria Chen, Philip O. Riendeau, Sarah Jabeen Qureshi

Patient Education Projects

No abstract provided.

Implicit Bias Mask 2023: Navigating Biases, Alexander Aly Restum, Alexandra M. Stone, Anna E. Lundh, Bradley David Libs, Caitlin Torrenueva Alindogan, Jaylin Marx Jones

Patient Education Projects

No abstract provided.

Implicit Bias Mask 2023: What The Eyes Do See: Learning To Grow And Respond, Aminah Juma Bharadia, Beverly Fu, Emma Ho Harris, Gabriel Khazal Boudagh, Michael David Mello, Sriraj Atluri

Patient Education Projects

No abstract provided.

Implicit Bias Mask 2023: Fears Of The Unknown Impacts Growth Mindset, Ananya L. Yanamandra, Christopher F. Ross, Danny Dean Salka, Hamza Khan, Julie Marie Waineo, Karen Elizabeth Zapien-Guerra

Patient Education Projects

No abstract provided.

Implicit Bias Mask 2023: Perception Of Patients Effects Implicit Biases, Chase Francis Moscovic, Abed Al-Kader Najjar, Deanna Nicole Brown, Natalie Anne Erickson, Rebecca M. Weber, Tyler Stephen Zweng

Patient Education Projects

No abstract provided.

Implicit Bias Mask 2023: Look Inwards And Acknowledge Biases, Alexandra Marie Crawford, Heather Jingxin Sun, Hyeok Jun Lee, Kenneth Tyrone Jackson, Mannat Kaur Bedi, Kyle James Mastalerz

Patient Education Projects

No abstract provided.

Implicit Bias Mask 2023: Skills Set And Values Influence Growth Mindset, Abigail Ruby Bojanowski, Benjamin Erik Frimodig, Mark D. Sprague, Michael D. Mason, Minie Zhang, Sruti Ramamoorthy

Patient Education Projects

No abstract provided.

Implicit Bias Mask 2023: Uncovering And Addressing Implicit Bias In A Healthcare Setting, Alexandra Lily Thompson, Andrew Yuhua Wu, Lauren Mi-Yun Kim, Meghana Rao Jalagam, Rahul Bodapati, Tyler M. White

Patient Education Projects

No abstract provided.

Implicit Bias Mask 2023: Addressing Biases With A Multifaceted Approach, Ariana Noor Afrakhteh, Christian Versin, Joseph Edward Kananen, Meghna Duvoor, Mitchell Leon Rits, Natalie R. Aulicino

Patient Education Projects

No abstract provided.

Implicit Bias Mask 2023: Consciously Work On Biases, Camden Watson Gardner, Dina Saban, Hasan Ali Sawan, Kaitlyn Ann Zablock, Nikesh Vijay Thadani, Nishith Sagubadi

Patient Education Projects

No abstract provided.

Implicit Bias Mask 2023: Acknowledge And Minimize Biases, Arianna Reyes Arcenas, Colton Clymer, Henry W. Li, Jonathan T. Albrecht, Kathleen Elise Girdler, Saleh Ahmed

Patient Education Projects

No abstract provided.

Implicit Bias Mask 2023: Predicting Implicit Biases Fosters Growth Mindset, Alexander Patrick Hayes, Dominic Jude Sacca, Indrea L. Joplin, Kendyll Jill Gartrelle, Owen G. Stratton, Whitney Lynn Bowyer

Patient Education Projects

No abstract provided.

Implicit Bias Mask 2023: Use Unique Lens Of Empathy And Employ Strategies For Growth Mindset, Douglas T. Nefcy, Arianna I. Afonso, Kelly Yue Chen, Ken Huynh, Louie Elias Mekani, Megan Clare Z. Carulla

Patient Education Projects

No abstract provided.

Implicit Bias Mask 2023: Ways To Suppress Biases, Blake W. Bergeson, Oase Muhammad Sbei, Chidinma Ozioma Iheanyi-Okeahialam, Emily Bao-Tram Vu, John E. Romanowski, Julia Austin Rinck

Patient Education Projects

No abstract provided.

Implicit Bias Mask 2023: Acknowledge Biases, Constantine Theodore Tangalos, Fabiola S. Cuellar, Farheen Rahmat Vali, Hana Hongying Jiang, Kevin Leung Chau, Rahul Babu

Patient Education Projects

No abstract provided.

Implicit Bias Mask 2023: Health Biases Effects Professional Identity, Julia C. Tenbusch, Kaelan Sudhanshu Patel, Maxim Alexander Jani, Nand Kumar Ganesh, Nicole Brianna Flores, Venkata Patchigolla

Patient Education Projects

No abstract provided.

Implicit Bias Mask 2023: Behind The Mask, Ameen Haroon Khan, Aria Christine Hutchinson, Caitlin Ann Tan Benitez, Daniel L. Poe, Dawson D. Sloan, Shivani Bongu

Patient Education Projects

No abstract provided.

Traumatic Stress-Induced Increases In Anxiety-Like Behavior And Alcohol Self-Administration Are Mediated By Central Amygdala Crf1 Neurons That Project To The Lateral Hypothalamus, Marcus M. Weera, Daniel A. Webster, Rosetta S. Shackett, Federica Benvenuti, Jason W. Middleton, Nicholas W. Gilpin

School of Graduate Studies Faculty Publications

Avoidance stress coping, defined as persistent internal and/or external avoidance of stress-related stimuli, is a key feature of anxiety- and stress-related disorders, and contributes to increases in alcohol misuse after stress exposure. Previous work using a rat model of predator odor stress avoidance identified corticotropin-releasing factor (CRF) signaling via CRF type-1 receptors (CRF1) in the central amygdala (CeA), as well as CeA projections to the lateral hypothalamus (LH) as key mediators of conditioned avoidance of stress-paired contexts and/or increased alcohol drinking after stress. Here, we report that CRF1-expressing CeA cells that project to the LH are preferentially activated in male …

Pimavanserin 34 Mg At Bedtime For The Treatment Of Insomnia In 6 Veterans With Posttraumatic Stress Disorder, Melissa B Jones, Ritwick Agrawal, Amir Sharafkhaneh, Gursimrat Bhatti, Ruosha Li, Laura Marsh, Ricardo E Jorge

Faculty, Staff and Student Publications

No abstract provided.

Nk Cell Expansion Requires Hur And Mediates Control Of Solid Tumors And Long-Term Virus Infection, Sytse J Piersma, Sushant Bangru, Jeesang Yoon, Tom W Liu, Liping Yang, Chyi-Song Hsieh, Beatrice Plougastel-Douglas, Auinash Kalsotra, Wayne M Yokoyama

2020-Current year OA Pubs

Natural killer (NK) cells are lymphocytes capable of controlling tumors and virus infections through direct lysis and cytokine production. While both T and NK cells expand and accumulate in affected tissues, the role of NK cell expansion in tumor and viral control is not well understood. Here, we show that posttranscriptional regulation by the RNA-binding protein HuR is essential for NK cell expansion without negatively affecting effector functions. HuR-deficient NK cells displayed defects in the metaphase of the cell cycle, including decreased expression and alternative splicing of Ska2, a component of the spindle and kinetochore complex. HuR-dependent NK cell expansion …

Mechanistic Toxicology In Light Of Genetic Compensation, Mary Jane Elizalde, Daniel A Gorelick

Faculty, Staff and Students Publications

Mechanistic toxicology seeks to identify the molecular and cellular mechanisms by which toxicants exert their deleterious effects. One powerful approach is to generate mutations in genes that respond to a particular toxicant, and then test how such mutations change the effects of the toxicant. CRISPR is a rapid and versatile approach to generate mutations in cultured cells and in animal models. Many studies use CRISPR to generate short insertions or deletions in a target gene and then assume that the resulting mutation, such as a premature termination codon, causes a loss of functional protein. However, recent studies demonstrate that this …

Late-Gadolinium Enhancement Is Common In Older Pediatric Heart Transplant Recipients And Is Associated With Lower Ejection Fraction, Andrew A Lawson, Kae Watanabe, Lindsay Griffin, Christina Laternser, Michael Markl, Cynthia K Rigsby, Melanie Sojka, Joshua D Robinson, Nazia Husain

Faculty, Staff and Students Publications

BACKGROUND: Chronic graft failure and cumulative rejection history in pediatric heart transplant recipients (PHTR) are associated with myocardial fibrosis on endomyocardial biopsy (EMB). Cardiovascular magnetic resonance imaging (CMR) is a validated, non-invasive method to detect myocardial fibrosis via the presence of late gadolinium enhancement (LGE). In adult heart transplant recipients, LGE is associated with increased risk of future adverse clinical events including hospitalization and death. We describe the prevalence, pattern, and extent of LGE on CMR in a cohort of PHTR and its associations with recipient and graft characteristics.

METHODS: This was a retrospective study of consecutive PHTR who underwent …

Randomized Clinical Trial Of Low Dose Suramin Intravenous Infusions For Treatment Of Autism Spectrum Disorder, David Hough, Alice R Mao, Michael Aman, Reymundo Lozano, Constance Smith-Hicks, Veronica Martinez-Cerdeno, Michael Derby, Zachary Rome, Niel Malan, Robert L Findling

Faculty, Staff and Students Publications

Background: There is a critical need for effective treatment of the core symptoms of autism spectrum disorder (ASD). The purinergic antagonist suramin may improve core symptoms through restoration of normal mitochondrial function and reduction of neuro-inflammation via its known antagonism of P2X and P2Y receptors. Nonclinical studies in fragile X knockout mice and the maternal immune activation model support these hypotheses.

Methods: We conducted a 14 week, randomized, double-blind, placebo-controlled proof -of-concept study (N = 52) to test the efficacy and safety of suramin intravenous infusions in boys aged 4-15 years with moderate to severe ASD. The study had 3 …

See Me, Hear Me, Know Me: Perspectives On Diet And Physical Activity Influences Among Teens Living In Rural Texas Communities, Debbe Thompson, Julie Miranda, Chishinga Callender, Jayna M Dave, Godlove Appiah, Salma M A Musaad

Faculty, Staff and Students Publications

Teens in rural communities are at greater risk of obesity than teens in urban areas. Diet and physical activity influence obesity risk. Understanding their perspectives is an important step in intervention design. This qualitative investigation explored teen perspectives on how living in a rural community influenced their diet and physical activity choices. Forty parent-teen pairs were recruited. Data collection included surveys and telephone interviews. This paper reports teen perspectives identified in the first interview. Thematic analysis was used to code and analyze the data. Findings revealed that the primary factor driving teens' diet and physical activity behaviors was the teens …

Molecular Mechanisms Of Twist1-Regulated Transcription In Emt And Cancer Metastasis, Xiaobin Yu, Tao He, Zhangwei Tong, Lan Liao, Shixia Huang, Walid D Fakhouri, Dean P Edwards, Jianming Xu

Faculty, Staff and Students Publications

TWIST1 induces epithelial-to-mesenchymal transition (EMT) to drive cancer metastasis. It is yet unclear what determines TWIST1 functions to activate or repress transcription. We found that the TWIST1 N-terminus antagonizes TWIST1-regulated gene expression, cancer growth and metastasis. TWIST1 interacts with both the NuRD complex and the NuA4/TIP60 complex (TIP60-Com) via its N-terminus. Non-acetylated TWIST1-K73/76 selectively interacts with and recruits NuRD to repress epithelial target gene transcription. Diacetylated TWIST1-acK73/76 binds BRD8, a component of TIP60-Com that also binds histone H4-acK5/8, to recruit TIP60-Com to activate mesenchymal target genes and MYC. Knockdown of BRD8 abolishes TWIST1 and TIP60-Com interaction and TIP60-Com recruitment to …

Perspectives On Research Needs In Healthcare Epidemiology And Antimicrobial Stewardship: What's On The Horizon - Part I, Jonas Marschall, Rachael E Snyders, Hugo Sax, Jason G Newland, Thais Guimarães, Jennie H Kwon

2020-Current year OA Pubs

In this overview, we articulate research needs and opportunities in the field of infection prevention that have been identified from insights gained during operative infection prevention work, our own research in healthcare epidemiology, and from reviewing the literature. The 10 areas of research need are: 1) transmissions and interruptions, 2) personal protective equipment and other safety issues in occupational health, 3) climate change and other crises, 4) device, diagnostic, and antimicrobial stewardship, 5) implementation and de-implementation, 6) health care outside the acute care hospital, 7) low- and middle-income countries, 8) networking with the "neighbors", 9) novel research methodologies, and 10) …

Association Between User Interaction And Treatment Response Of A Voice-Based Coach For Treating Depression And Anxiety: Secondary Analysis Of A Pilot Randomized Controlled Trial, Nan Lv, Thomas Kannampallil, Lan Xiao, Corina R Ronneberg, Vikas Kumar, Nancy E Wittels, Olusola A Ajilore, Joshua M Smyth, Jun Ma

2020-Current year OA Pubs

BACKGROUND: The quality of user interaction with therapeutic tools has been positively associated with treatment response; however, no studies have investigated these relationships for voice-based digital tools.

OBJECTIVE: This study evaluated the relationships between objective and subjective user interaction measures as well as treatment response on Lumen, a novel voice-based coach, delivering problem-solving treatment to patients with mild to moderate depression or anxiety or both.

METHODS: In a pilot trial, 42 adults with clinically significant depression (Patient Health Questionnaire-9 [PHQ-9]) or anxiety (7-item Generalized Anxiety Disorder Scale [GAD-7]) symptoms or both received Lumen, a voice-based coach delivering 8 problem-solving treatment …