Medicine and Health Sciences Commons^™

The Role Of Family Support In The Relationship Between Childhood Obesity And The Number Of Days Bullied In Trinidad, Sharon Antoine-Mills

Walden Dissertations and Doctoral Studies

There is limited data on childhood obesity and the number of days bullied in Trinidad and Tobago. This study examined the association between childhood obesity and the number of days an obese child has been bullied in Trinidad in the past 30 days, with family support as a moderator. The theoretical framework for this study was Bronfenbrenner’s social-ecological model, which posits that a child’s microsystems are instrumental in influencing their behaviors. A self-administered low-cost 2017 Global School-based Student Health Survey (GSHS) was used for this cross-sectional study. The sample comprised 2,229 school adolescents 13 to 17 years of age. Childhood …

Experience Of Established Mental Health Counselors Working With Adults Who Have Intellectual Disabilities, Margarete Denk

Walden Dissertations and Doctoral Studies

Individuals with disabilities make up the largest minority population in the United States. Individuals with intellectual and developmental disabilities (I/DD) make up a significant portion of this population, yet there are limited studies addressing counseling with the I/DD population. The Council for Accreditation of Counseling and Related Educational Programs has addressed the need for disability competence in their upcoming 2024 standards. The purpose of the phenomenological study was to describe lived experiences of established counselors working with adult clients diagnosed with an I/DD. A descriptive phenomenological approach was used along with the social model of disability. The study involved six …

Disparate Access To Medical Coverage Associated With Type 2 Diabetes Care In Low-Income And Rural Communities In Georgia, Crystal Alexis Symone Edwards

Walden Dissertations and Doctoral Studies

Disparate access to diabetes care in rural and low-income communities among older adults has been an ongoing issue among Americans. Type 2 diabetes in low-income and rural communities has continuously burdened many residents due to age, costs of care, income, geographic location, and education levels. Researchers have demonstrated that providing resources and tools to rural and low-income communities would assist in decreasing type 2 diabetes and increase education and awareness. The purpose of this quantitative cross-sectional study using secondary data was to examine the relationship between health insurance status and lack of access to health care resources and delay of …

Fall Risk Among Older Adults: Major Risk Factors, Primary Assessment Tools, And The Influence Of Medications, Marie Roseann Jensen

University of the Pacific Theses and Dissertations

Fall risk among older adult is a worldwide public health problem. As the older adult population is continuing to increase, addressing this issue is critical. Several fall risk assessment tools have been designed to help predict various risk factors. Among these assessment tools is the Hendrich II Fall Risk Model (HIIFRM). This tool uses evidence-based risk factors including mental status, sex, functional status, and whether the patient is taking antileptics and/or benzodiazepines. The purpose of this paper is to validate the HFRM, explore additional variables that increase the likelihood of falling including both past falls and the number of prescription …

Role Of Cysteine Redox State In Altering The Epithelial-Mesenchymal Transition In Lung Cancer, Md Anisur Rahman

University of the Pacific Theses and Dissertations

Epithelial-mesenchymal transition is a process by which cancer cells increase their capability for metastasis. EMT involves conversion of epithelial cells into a mesenchymal phenotype which makes cancer cells more invasive and motile. Lung cancer has the highest mortality rate among different types of cancers globally. Lung cancer exists in various types, the most prevalent of which is non-small cell lung cancer (NSCLC). Several factors, including oxidative stress, can induce EMT in cancer cells. However, the mechanism of how reactive oxygen species (ROS)-induced changes in cysteine redox state affect EMT remains elusive. Our studies aim to understand this mechanism by inducing …

Investigating Bzip Recognition Of Dna Sequences Through A Knob-Socket Perspective, Aaron Tran

University of the Pacific Theses and Dissertations

To investigate whether higher order packing interactions confer protein-DNA specificity, a modified Knob-Socket (KS) model was used to analyze the interface of bZIP-DNA crystal structures. The KS analysis identified a nine-residue quadripartite recognition core consisting of four contiguous KS pockets P1, P2, N3, and N4 that each pack one of the four DNA half-site bases in the target sequence. Only one base per base pair packs, and these interactions are split across the DNA strands: the first two positive strand positions 1p and 2p pack into P1 and P2 while the last two negative strand positions 3n and 4n pack …

Exercise Behavior And Recreational Sports Participation Predicts Academic Success In University Students, Natalie Matian

University of the Pacific Theses and Dissertations

Most universities offer fitness and recreational opportunities. Few prospective studies have measured the effect of those services on academic outcomes. The purpose of this study is to evaluate the effect of exercise behavior and recreational sport participation on student success. We tracked 1,507 students at a private D1 university for 4 years. Upon completion of the 2017-2018 academic year, we exported a registry of every undergraduate student who accessed the university fitness center. We documented how often students swiped into the recreation facility and participated in group exercise classes, personal training sessions, and rock tower usage; these served as independent …

Evaluation Of Human Stem Cell-Derived Neurons In 2d And 3d Cultures For Neurodevelopmental Studies, Epilepsy Disease Modeling And Drug Discovery, Hamed Salmanzadeh-Dozdabi

University of the Pacific Theses and Dissertations

Human stem cells have revolutionized the study of early neural development, offering a powerful tool to investigate the complex processes involved in the formation of the nervous system. In this study, the human pluripotent stem cell line, TERA2.cl.SP12, was utilized to derive neuroglial cells and to determine their differentiation and functional maturation up to one year in culture; this model was then investigated as a new tool for the study of neurodevelopmental toxicity, for seizure modeling and as a screening method for the investigation of new anticonvulsants. Immunocytochemistry experiments determined that non-differentiated cells expressed the stem cell marker Oct-3/4 and, …

Targeting Ribonucleotide Reductase For Breast Cancer Treatment, Nahid Sultana

University of the Pacific Theses and Dissertations

Breast cancer is the second most common type of cancer in the world. Hormone receptor (HR) positive breast cancer (BC) is a prevalent disease accounting for approximately 2 million new cases globally. Almost 70-80% of breast cancer patients are women with a positive score for the estrogen receptor (ER). Triple-negative breast cancer (TNBC) which have a negative score for estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor type 2 (HER2) is considered an aggressive histological breast cancer subtype with limited treatment options.Frequently, doxorubicin (DOXO)-based chemotherapy is utilized in this patient population due to the lack of …

Enhancing The Half-Life Of Interleukin 2 By Conjugation To The Transthyretin Ligand, Tlhe And Enhancing The Efficacy Of Peptides That Inhibit Covid 19 Viral Entry, Arjun D. Patel

University of the Pacific Theses and Dissertations

The central dogma of biology states that genetic information describes the flow ofinformation from DNA to RNA and then finally resting in proteins. The fundamental aspect that underlies all aspects of life is the expression and modification of proteins. One can even argue that there is no life without proteins. As such, many human diseases are either directly or indirectly related to dysfunction of proteins and can potentially be solved through protein therapeutics. Consequently, scientists have begun to harness the diversity of proteins to treat the diseases which plague man in the form of protein therapeutics such as clotting factors, …

Influence Of Female Sex Hormones On Ghb Toxicokinetics And Regulation Of Mcts And Smcts, Hao Wei

University of the Pacific Theses and Dissertations

Gamma-hydroxybutyric acid (GHB) is an endogenous shorty chain fatty acid that is used clinically as Xyrem to treat narcolepsy. GHB is best known for its illicit use and abuse due to its sedative/hypnotic and euphoric effects. It is used in body building, for recreational use and sexual assault. Nonlinear toxicokinetics of GHB has been described in humans and rats with decreased total clearance at higher doses due to capacity-limited metabolism resulting in a higher plasma exposure. Renal clearance increases with increasing dose and becomes the major route of GHB elimination in overdose cases due to saturation of GHB metabolism. Proton- …

The Degradation Mechanisms Of Aryl Hydrocarbon Receptor In Human Lung Epithelial Carcinoma A549 Cells, Rui Xiong

University of the Pacific Theses and Dissertations

The aryl hydrocarbon receptor (AHR), a cytosolic ligand-activated transcription factor, has been acknowledged as a critical regulator of xenobiotic-induced toxicity and carcinogenesis. In the absence of ligand, the AHR is cytoplasmic in a complex with Hsp90, p23, XAP2, and Src. The AHR complex translocates to the nucleus upon ligand binding. After releasing its chaperones, it forms a heterodimer with ARNT, which subsequently binds to a dioxin-responsive element (DRE) for target genes transcription. Multiple aspects of cells are altered by the substantial expression of AHR target genes. Even without the AHR ligand, the cytoplasmic AHR plays a critical role in tumor …

Advocacy Spotlight: Mda’S Legislative Priorities For 2023, Neema Katibai Jd

The Journal of the Michigan Dental Association

This article outlines the Michigan Dental Association's (MDA) legislative priorities for the year 2023. The MDA focuses on various key issues, including dental loss ratio, network leasing transparency, teledentistry policy, the state budget's impact on dental services, increasing the dental workforce, and addressing student debt relief. These priorities aim to advocate for the dental profession, enhance patient care, and ensure the dental community's well-being.

Factors Associated With Patient Portal Utilization, Preventive Services Utilization, And Health Promoting Behaviors Among Adults In The United States, Elizabeth Ayangunna

College of Graduate Studies: Theses & Dissertations

Background: Nearly 60% of adults in the United States are estimated to have one or more chronic conditions, necessitating strategies to improve the health status of persons with chronic disease. Given that health information technology (HIT) is considered highly valuable for superior disease management, it is imperative to examine how HIT use can improve health behaviors, which can in turn improve health status. This study aimed to examine if there was an association between patient portal utilization and the use of preventive services & health-promoting behaviors. Also, this study examined the influence of self-efficacy on preventive health behaviors among adults …

Training Specificity And Functional Performance In Collegiate Cheerleaders, Carly Routman

College of Graduate Studies: Theses & Dissertations

INTRODUCTION: Competitive collegiate cheerleading requires participants to be conditioned for explosive powerful movements. Studies have shown cheerleading is associated with a high incidence of catastrophic injury (Mueller, 2009; Boden, 2005; Xu et al., 2021). In response to high injury rates, studies have recommended strength and conditioning requirements to decrease the likelihood of injury due to the lack of cheer-specific training (Jacobson et al., 2004). Although it has been recommended for cheerleaders to receive formal strength training, many schools do not provide these resources to their cheerleading teams. PURPOSE: The purpose of this study was to determine if there are differences …

Evaluation Of The Loving Support Peer Counseling Program On Breastfeeding Duration Rates Among African American Women Enrolled In The Program (2017-2018), Nancy S. Jeffery

College of Graduate Studies: Theses & Dissertations

Mothers and babies form an inseparable biological and social unit; the health and nutrition of one group cannot be divorced from the health and nutrition of the other.”-World Health Organization. The aim of this study was to evaluate the effectiveness of the Loving Support Peer Counseling (LSPC) program, under the WIC program in the state of Georgia, on breastfeeding duration rates among African American postpartum primiparas women. This observational study analyzed state-level data from January 2017 through December 2018. A cross-sectional design was used to evaluate the effectiveness of the Loving Support Peer Counseling Program (LSPC) in six of the …

Staffing Up For A Pandemic And Beyond: Utilizing A Prn Nursing Pool, Leyna Mashburn, James Watkins

Georgia Public Health Association Annual Meeting & Conference

The COVID-19 pandemic’s early vaccination stage required health department staff to work long, odd hours to accommodate the needs of Georgia residents. This presented a challenge since some health departments only have 2-3 full-time nurses. District 2 hired a pool of PRN nurses to cover significant gaps in workforce throughout multiple vaccination phases of the pandemic response. This additional workforce allowed District 2 to maximize number of vaccine doses given.

During later COVID vaccination phases (summer 2021 – present), PRNs allowed health departments to resume regular services alongside high vaccination capacity. With various funding sources, District 2 used the PRNs …

Knowledge Of Pregnancy And Postpartum Complications Up To One Year Postpartum Compared By Rurality, Evelyn Frances Fagan, Alisha Riggins, Ariel A. Alston, Mario Keko, Ana M. Palacios, Helen Bland, Joanne Chopak-Foss

Georgia Public Health Association Annual Meeting & Conference

Introduction: Georgia has one of the highest maternal mortality rate in the U.S. at 46.2 maternal deaths per 100,000 live births, disproportionately affecting Black and rural populations. This study sought to 1) assess knowledge of Georgian adults about complications and urgent warning signs both during pregnancy and up to 1-year postpartum, and 2) characterize knowledge within rural and urban population.

Methods: As part of a larger study, an online survey with previously validated questions was distributed to Georgia residents through social media and email. Data was grouped into 2 different categories: 1) pregnancy warning signs and 2) post-partum warning signs. …

The Effect Of Metalation On Antimicrobial Piscidins Imbedded In Normal And Oxidized Lipid Bilayers, Ana Dreab, Craig A. Bayse

Chemistry & Biochemistry Faculty Publications

Metalation of the N-terminal Amino Terminal Cu(II)- and Ni(II)-binding (ATCUN) motif may enhance the antimicrobial properties of piscidins. Molecular dynamics simulations of free and nickelated piscidins 1 and 3 (P1 and P3) were performed in 3 : 1 POPC/POPG and 2.6 : 1 : 0.4 POPC/POPG/aldo-PC bilayers (POPC, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine: POPG, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol; aldo-PC, 1-palmitoyl-2-(9′-oxo-nonanoyl)-sn-glycero-3-phosphocholine) bilayer models. Nickel(II) binding decreases the conformation dynamics of the ATCUN motif and lowers the charge of the N-terminus to allow it to embed deeper in the bilayer without significantly changing the overall depth due to interactions of the charged half-helix …

Longitudinal Oxygen Imaging In 3d (Bio)Printed Models, Ryan Curtis O'Connell

Graduate Theses, Dissertations, and Problem Reports (ETD)

Electron paramagnetic resonance (EPR), and its molecular imaging modality, is a powerful tool to noninvasively map various biological and chemical markers within objects of interest. Reliable data acquisition is a major impeding factor for longitudinal hands-off measurements. Measurements are especially challenging in biomedical applications, as live objects are not static. Frequent changes occur that require constant fine recalibration of the EPR detection system, called the resonator. To enable longitudinal imaging, a technology permitting automatic digital control of resonator coupling, tuning, and EPR data acquisition was developed. Automation was achieved through the utilization of a microcontroller and digital peripheral components such …

Acceleration Patterns During Standing And Running Tumbling Passes In Collegiate Cheerleading, Benjamin L. Paquette

College of Graduate Studies: Theses & Dissertations

Tumbling requirements and expectations of heightened difficulty of tumbling skills has grown to become a vital component in competitive collegiate cheerleading. Acceleration patterns during tumbling skills has been previously explored in gymnastics, with a floor routine being the most similar in nature, but not completely transferable considering differences in tumbling surface, execution strategy, and setting. Therefore, the purpose of this study was to investigate acceleration patterns during different tumbling passes in collegiate cheerleading athletes. Fifteen female collegiate cheerleaders (age = 19.6 + 1.50) participated in the study. Each participant completed a max of seven different tumbling passes (two standing, 5 …

Review Of Diagnostic Accuracy Of The Ottawa Knee Rules In Adult Acute Knee Injuries, Sean L. Glover, Amy M. Loveless, Sara A. Posson, Zachary K. Winkelmann

Clinical Practice in Athletic Training

Acute knee injuries are commonly found in athletic populations. The wide range of knee injuries can present a challenge deciding which injuries require imaging. Currently, radiography is considered the gold standard of imaging for knee fractures. However, imaging is often costly not only for the patient, but also for the healthcare system. Since imaging is expensive, it is critical that clinicians decipher which patients require such testing. The Ottawa Knee Rules (OKR) is a predictor tool created by Stiell et al in 1995 to help clinicians accurately distinguish potential knee fractures from non-fractures for imaging purposes. The OKR guidelines state …

The Impact Of Bracing On Kinesiophobia And Recovery In Acl Reconstruction Patients: A Case Study, N Valdecanas, K Neelon, K Braunreiter

Clinical Practice in Athletic Training

Introduction: With 100,000 to 200,000 cases reported in the U.S. yearly, the anterior cruciate ligament (ACL) is a commonly torn structure in the knee among contact and non-contact sports. As medical research on ACL injuries grows, ACL reconstruction (ACLR) continues to be the preferred surgical intervention. Due to extensive rehabilitation timeline requirements, ACLR patients may face physical and psychosocial circumstances affecting their overall recovery. At any point in rehabilitation the patient may experience kinesiophobia, or an irrational fear relating to further injury from participation in physical movement, especially with return to running, jumping, and sports-specific programs. Functional bracing has been …

Intersectionality Of Self-Reported Food Insecurity And Perceived Stress Of College Students At A Land-Grant Southeastern Higher Education Institution During The Covid-19 Pandemic, Kendra Oonorasak, Makenzie Barr, Michael Pennell, Dylan Hardesty, Kotomi Yokokura, Samantha Udarbe, Tammy Stephenson

Journal of Higher Education & Student Affairs

College food insecurity (FI) and poor psychosocial health are prevalent public health issues in the U.S., yet often overlooked. Since the COVID-19 pandemic, repercussions on these critical inequity issues remain unclear. During the summer months of 2020, this cross-sectional survey examined associations between students’ self-reported FI and perceived stress (PSS-10), one aspect of poor psychosocial health. An anonymous online survey was distributed to a convenience sample of college students at a land grant institution of higher education in the southeastern U.S., and $10 e-gift card was provided to survey respondents. The survey response rate was 26.2% (n=235) and participants were …

A Study To Examine The Relationship Between Ceo Characteristics And Organizational Performance In The Us Pharmaceutical And Biopharmaceutical Industries, Wafick K. Mohamed

All ETDs from UAB

This study examined the relationship between CEO tenure, sex, level of education, and organizational performance across 229 U.S. publicly traded pharmaceutical and biopharmaceutical companies. The Upper Echelons Theory was used to guide this research on how CEO characteristics could impact organizational performance. Fifteen hypotheses were developed and tested to evaluate the statistically significant relationship between CEO tenure, sex, level of education, and the organizational performance demonstrated in the abnormal stock return valuation and the number of FDA-approved drug products in clinical trial phases (phases 1, 2, and 3) for each company. This quantitative, non-experimental, and cross-sectional study was completed by …

The Genetic Epidemiology Of Complex Lung Diseases, Ava Claire Wilson

All ETDs from UAB

This research utilizes precision medicine techniques to advance our understanding of Chronic Obstructive Pulmonary Disease (COPD) and Idiopathic Pulmonary Fibrosis (IPF) with the overall goal of improving the etiology of and identifying molecular targets and pathways in COPD and IPF to help improve patient outcomes. We aimed to 1) identify novel drug targets and uncover potential mechanisms by which pirfenidone and nintedanib attenuate fibrosis by performing an integrative ‘omics analysis of transcriptomics and proteomic responses to TGFb1-stimulated lung fibroblasts; 2) define a skeletal muscle fiber shift phenotype in both males and females with COPD and begin to disentangle underlying mechanisms …

Assessing Visual Function In Young And Medically Complex Children With Cerebral Visual Impairment, Kathleen Mary Weden

All ETDs from UAB

Cerebral Visual impairment (CVI) has become the leading cause of vision impairment in children worldwide. Early identification of CVI has been shown to improve visual function outcomes and improve developmental outcomes and quality of life. However, children with CVI are difficult to identify and assess because the medical conditions that cause CVI can also cause impairment across domains of function. A scoping review was first conducted on interventions and outcome measures used for children with CVI. The sources identified (n=20) were grouped into five types of interventions. The review confirmed the need for quantitative, standardized methods for measuring visual function …

Transcriptional Regulation In Early Stage Cd4+ T Cell Activation And Differentiation, Andrew Ray Schroeder

All ETDs from UAB

CD4+ T cells regulate the humoral and cellular immune responses by differentiating into T follicular helper (Tfh) cells or into non-Tfh effector cells. Non-Tfh effector cells leave the lymph node and migrate to the effector site whereas Tfh cells upregulate CXCR5 and migrate towards the B cell follicle. The mechanism of CXCR5 induction, however, is still incompletely understood. The transcription factor Bach2 was shown to inhibit the in vitro differentiation of Th1, Th2, and Th17 cells as well as the in vivo Tfh responses. Though, it is unknown how Bach2 arbitrates Tfh and non-Tfh differentiation in vivo. Here, we report …

The Effects Of Cannabidiol On Brain Temperature In Treatment-Resistant Epilepsy, Ayushe A. Sharma

All ETDs from UAB

Epilepsy affects over 70 million people worldwide with a global incidence of 2.4 million new cases per year. In many of these patients, neuroinflammation (NI) is a key pathological contributor to focal seizure generation and maintenance. Sustained NI degrades the blood–brain barrier, leads to neuronal death, and ultimately decreases seizure threshold. Finding ways to image and treat NI is especially important for the >30% of patients with treatment-resistant epilepsy (TRE) who cannot achieve seizure freedom with standard antiseizure medications. Cannabidiol (CBD) effectively reduces seizure frequency and severity in many TRE patients, although its antiepileptic effects remain poorly understood. Atypically high …

Perceptionf Of Multipurpose Prevention Technologies Aimed At Hiv/Sti/Unintended Pregnancy Among African American Women In The Deep South, Kristina Wilbekin Walker

All ETDs from UAB

Sexual and reproductive health (SRH) needs for women are not being met globally. In addition to efforts towards providing widespread access to currently available contraceptives and sexually transmitted infection (STI) treatment or prevention products, another focus is the development of multipurpose prevention technologies (MPTs). These MPTs are combination methods that prevent pregnancy, and protect against HIV and/or additional STIs. The objective of this dissertation research was to assess factors related to sexual and reproductive decision-making that may influence interest in MPTs and inform MPT implementation strategies for African and African American (AA) women. The first aim of this research, I …