Medicine and Health Sciences Commons^™

The Prognostic Value Of Androgen Receptor And Cyclin D1 In Infiltrating Duct Carcinoma Of The Breast, Dina A Abd El-Ghaffar, Amal Af Halim, Eman A Abdallah, Doaa A Sharaf, Shaimaa M Yussif

Mansoura Medical Journal

Objective: Breast cancer (BC) tissue is heterogeneous with a number of cellular pathways involved in cell growth and proliferation. Activation of androgen receptors (AR) signaling pathways plays a role in BC. On the other hand, cyclin is a regulatory subunit of cyclin dependent kinases that affect cell cycle G1/S transition. This study aimed at investigating the relationship between the expression of AR and cyclin D1 and the clinicopathological details of BC patients registered in the archive of our department within a specified period and determining the prognostic impact of such expression.

Methods: The study included 182 IDC patients aged from …

The Effect Of Hepatitis C Virus Infection On Ovarian Reserve, Khaled Mahmoud Ahmed Amin Abdo, Mahmoud Mohamed Abdelrazik, Eman Salah Eldin Mohamed Fadel, Ashraf Ahmed Foda, Mohamed Abd Ellatif Elnegeri

Mansoura Medical Journal

Background: Hepatitis C has the highest frequency in Egypt, with 14.7 percent of the population affected between the ages of 15 and 49, according to the World Health Organization. Hepatitis C virus antibodies have been detected in 12.2% of women and 17.4% of men. Patients and Methods: This research was carried out in Mansoura University Hospital, Mansoura, Egypt. All participants (90 cases) in this study provided written informed consent to participate and were separated into 2 groups, the first group (group A) & the second group (group B). Women in group A (45 cases) were hepatitis C virus antibodies tested …

Outcome Of Covid-19 In Patients With Rheumatic Diseases Treated With Immunosuppressive Drugs, Ali Sobh, Noha Hazem Elnagdy, Mohamed Elegezy, Mohamed Mofreh, Mohamed Tohlob, Ahmad M. Eita, Ragheed Rizk, Ola Eliwa, Marwa H. Elnagdy, Ahmed Elsaeed Abdulgalil

Mansoura Medical Journal

Background: Rheumatologic disorders have been significantly impacted by the coronavirus disease 2019 (COVID-19) pandemic. The potential role of immunosuppressive drugs in the presentation, severity and even management of COVID-19 is still questionable. The aim of this work was to study the effect of immunosuppressive drugs on outcome of COVID-19 infection in patients with rheumatic diseases. 109 rheumatic patients (37 pediatrics and 72 adults) taking immunosuppressive treatment with confirmed COVID-19 infection were included in this study. Clinical, laboratory, radiological findings and outcome of these patients were retrospectively retrieved from hospital medical records. Results: The majority of adult cases were rheumatoid arthritis …

Total Serum Immunoglobulin E In Patients With Psoriasis Vulgaris, Sara A. Gooda

Mansoura Medical Journal

Introduction Psoriasis vulgaris (PV) is a multifactorial disease in which some environmental factors acting on people who have a particular genetic predisposition trigger immune dysregulation and irregular keratinization, inducing typical cutaneous lesions. Serum IgE levels are low in normal subjects, on the other hand they increase in atopy, parasitic infestation, and particular forms of malignant tumours. The aim of this study was to assess serum levels of total IgE in cases with PV. Methods This research was a case-control study and comprised 40 psoriasis cases and matched age and sex 40 healthy subjects. Complete general and dermatological examination comprised a …

Unusual Late Presentation Of Kartagener Syndrome: A Case Report, Abdulhadi H. Al-Mazroea

Mansoura Medical Journal

Kartagener's syndrome (KS) is a rare inherited autosomal recessive condition. It comprises of the triad chronic sinusitis, bronchiectasis, and situs inversus. The symptoms are more prevalent in children in the early years of life. We describe a case of a 15-year-old child showing severe respiratory distress with a history of intermittent wet cough and rhinitis for the past six months. The patient was diagnosed with dextrocardia at birth and had no significant medical history since then. Based on his clinical presentation and imaging findings, he was diagnosed with KS that was confirmed by whole-exome sequencing. The patient was managed with …

Ultrasound Of Fetal Long Bone Ossification Centers As A Predictor Of Fetal Lung Maturity In Pregnant Ladies Scheduled For Elective Cesarean Section, Hala Mohammed Abu Zeid, Mohammed Tawfik Sayed, Abdelhady Zayed, Alhussein Ahmed Mohamed

Mansoura Medical Journal

ABSTRACT Background: In handling of pregnancy with elevated risk, fetal lung maturity (FLM) prediction is crucial. Long bone epiphyseal ossification centers (OCs) are considered to be a helpful predictor of (FLM), moreover, they can precisely identified and assessed easily. Aim: This research is trying to find out whether there is an association between OCs identification and FLM. Methods: This prospective study was carried out at the Mansoura University Hospital outpatient obstetric clinic. The Obstetrics and Gynaecology division at Mansoura University Hospitals recruited 100 full-term pregnant women. The major OCs were detected via ultrasound (US) as egg-shaped echo-rich zones. They were …

Assessment Of Serum Lipoprotein Phospholipase A2 As An Atherosclerotic Risk Factor In Ischemic Stroke Elderly Patients, Amr Ragab Yousef Ismael, Ahmed Saied, Ahmed Mohamed Elewa, Mohamed Said Gomaa

Mansoura Medical Journal

Background Significant evidence does exist regarding the significant role of inflammation in the development of atherosclerosis. Lipoprotein phospholipase A2 is a phospholipase A2 enzyme (Lp-PLA2) which is predominantly produced by macrophages and lymphocytes in atherosclerotic plaque. Increased Lp-PLA2 concentrations are significantly linked to atherosclerosis-related diseases which include cardiovascular diseases and ischaemic strokes. Aim This study was conducted to assess the role of serum level of Lp-PLA2 in cerebral atherosclerosis. Methods This prospective cross-sectional case-control study enrolled 100 patients aged 60 years old or more with acute ischaemic stroke (AIS). Using the TOAST classification, patients were divided into case group "atherosclerotic” …

Evaluation Of Platelet Indices And Low-Density Lipoprotein (Ldl) As Predictors Of Acute Ischemic Stroke Severity And Outcome, Ahmed E. Al-Sharabi, Ashraf A. El-Mitwalli, Yousra M. Tera, Hossam M. Egila

Mansoura Medical Journal

Background: Platelets play a role in atherosclerosis, inflammation, and thrombosis. Prothrombotic events, activation, aggregation, and adhesion are all increased by elevated mean platelet volume (MPV) and platelet distribution width (PDW) levels; high low-density lipoprotein (LDL) raises the risk of cardiovascular disease. Aims: Investigate the association between platelet indices, lipid profile, stroke severity, and outcome in patients with acute ischemic stroke. ‎ Subjects and methods: A prospective case-control study involved 100 acute ischemic stroke patients and 100 controls from Mansoura University Hospitals. Patients underwent neurological assessments, including the National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS), and Alberta …

Assessment Of Monocyte To High Density Lipoprotein Ratio And Ischemia-Modified Albumin In Acne Vulgaris Patients, Nermin Mamdouh Salem, Soheir Abdelgaber Eltoukhy, Mohammed Mohammed El Sayed El Arman, Sherief Refaat Ismail

Mansoura Medical Journal

Background: Acne vulgaris (AV) is a common, chronic, inflammatory lesion of the pilosebaceous unit. Oxidative stress played an essential role with regard to pathogenesis of many dermatological conditions. Aim: The aim of the present study is to assess Complete blood count (CBC) parameters and monocyte to high -density lipoprotein ratio (MHR) as indicator of inflammation, assess Ischaemia-modified albumin (IMA) as indicator of oxidative stress in acne vulgaris patients and to examine their relation to acne vulgaris severity. Methods: This was a case-control study included 48 acne vulgaris patients and 40 healthy individuals age and sex-matched controls. Global acne grading scale …

Effectiveness Of Allergen Immunotherapy In Cigarette Smokers With Allergic Airway Disorders, Heba Wagih Abdelwahab, Mostafa Bakeer, Ahmed Mohamed Fouda

Mansoura Medical Journal

Background: Exposure to environmental tobacco smoke (ETS) is associated with several medical diseases especially allergy, but little is known about the effects of cigarette smoking on allergen immunotherapy response. Aim: This study aims to explore any association between cigarette smoking and response to allergen immunotherapy in patients with allergic airway disorders. Patients and methods: The study was conducted on patients with allergic airway disorders who received subcutaneous immunotherapy. All patients were assessed as regard smoking history including pack-year index and dependence, symptoms and medication scores. Patients’ demographic and clinical data were collected. A statistical analysis was then performed. Results: A …

Evaluation Of Congenital Coronary Arteries Anomalies On Cardiac Computed Tomography Angiography (Cta) For Congenital Heart Diseases, Zainab A. Ramadan

Mansoura Medical Journal

Background and purpose: Coronary arteries anomalies (CAA) are generally rare but more common to co-exist with congenital cardiac anomalies. These include several congenital conditions either origin, course, or termination. This study aims to emphasize that the accurate evaluation of CAA on cardiac computed tomography angiography (CTA) is a must prior to proper surgical intervention in congenital heart diseases (CHD) to prevent unnecessary procedures or vascular injury of these vital arteries. Methods: Cardiac CTA scans for patients with suspected cardiac anomalies or diseases were retrospectively reviewed by radiologist for the presence of CAA between February 2020 and March 2023. CAA were …

Don’T Miss What Is Hidden On Cardiac Ct Angiography: Extra-Cardiac Findings Count, Zainab Ahmad Ramadan, Aya Ahmed Elboghdady, Aya Mohammed Abdel Aziz, Farah Ahmed Shokeir

Mansoura Medical Journal

Background: Multi-detector computed tomography (MDCT)is the main imaging modality in cardiovascular diseases. Another important role of MDCT is assessment of extra-cardiac structures outside the pericardium. These extra-cardiac findings may be of great relevance. Methods: Cardiac MDCT scan results were retrospectively reviewed by radiologist for the presence of extra-cardiac findings between February 2020 and December 2022. They were categorized according to anatomical location into systems as pulmonary, pleural, mediastinal, bronchial, vascular, bony, abdominal and miscellaneous. Results: A total of 955 patients had a cardiac multidetector CT angiography scan during the study period. Extra-cardiac findings were reported in 320 (33.5%) of these …

Developing A Computer-Based Program For Language Rehabilitation Of Arabic-Speaking Aphasic Patients, Sara Elsherbeny, Ayman Amer, Hemmat Baz, Tamer Abou-Elsaad

Mansoura Medical Journal

Background: Aphasia is acquired selective impairment of language. Computerized aphasia therapy is useful in language therapy and offers chances for independent practice at home to maximize intensity and improve outcomes. The aim of this study was to develop a computer-based language rehabilitation program for Arabic-speaking Egyptian aphasic patients to be culturally, linguistically and socially suitable for them and to determine its effectiveness. Methods: We conducted a prospective interventional study on 20 aphasic patients in the age range 40-65 years who received rehabilitation for 3 months using a newly designed Arabic software program named “Takalam”. The program was pilot-studied on 10 …

Assessing The Activity Of Inflammatory Bowel Disease Using The Serum Marker: Neutrophil Gelatinase Associated Lipocalin (Ngal), Fatma Abozeid, Karim Ali, Mounir Bahgat, Maha Maher, Asmaa M. Borg

Mansoura Medical Journal

Background: IBD, or inflammatory bowel disease, is an active and remitting illness. One of the most overexpressed genes in the colonic mucosa of patients with ulcerative colitis (UC) and Crohn's disease (CD) is lipocalin 2, the coding gene of neutrophil gelatinase associated lipocalin (NGAL). We investigated NGAL's applicability in assessing IBD activity. Methods: This study was a single center case control type. Thirty of the sixty IBD patients who participated in the study were in remission, and thirty were in active disease. Twenty-eight healthy controls were included. Enrolled were patients with CD or UC. The control group and all patients …

Role Of Serum Ferritin And D-Dimer On Short Term Outcome In Acute Ischemic Stroke, Nourhan Ahmed Galal Sadek, Mohammed Mahmoud Abbas Ali, Yousra Mahmoud Amin Tera, Mohamed Abd-El-Salam Mohamed Ali

Mansoura Medical Journal

Background: Acute ischemic stroke (AIS) has been considered as a main reason of death globally. Currently, intervention could significantly enhance outcomes and reduce disability. Studies have been conducted to determine the factors that may have a role in the context of AIS prognosis formulation. Prognostic indicators, that has gained great clinical interest recently, are serum ferritin and D-dimer (DD). Aim: The aim of the current study was to assess the relation between serum levels of both ferritin and DD and severity of AIS at time of presentation and its relationship with the short-term outcome of patients. Methods: The present study …

Myocardial And Renal Protective Effects Of Dexmedetomidine Vs Magnesium Sulphate In Patients Undergoing Elective Open Abdominal Aortic Surgery, Mohamed Younes Yousef Abd Allah, Maha Younes Youssef Abd-Allah, Abdelrahman Mohammed Elnagar

Mansoura Medical Journal

Background: After abdominal aortic aneurysm surgery, the likelihood of postoperative myocardial infarction is seven percent, but likelihood of postoperative cardiac problems without signs of ischemic damage is thirty-six percent. Aim: goal of research had been to assess perioperative myocardial protective impact of dexmedetomidine and magnesium sulphate in high‑risk studied cases undergoing aortic vascular surgery. Methods: This randomized double blinded research had been being done in cardiothoracic & vascular surgery center, Mansoura university from May 2023 to October 2023 after approval from institutional review board of faculty of Medicine Mansoura University with obtaining a written informed consent from all studied cases. …

Prevalence Of Colorectal Polyps And Associated Risk Factors In Egyptian Population: A Single Center Study, Hossam El Refaey, Hazem Hakim, Ahmed Saed

Mansoura Medical Journal

Background: Intestinal polyps are noticeable mucosal outgrowths that extend into lumen of gastrointestinal tract. In adults, the most frequently detected polyps are adenomatous polyps which are thought to be precursors of large bowel cancer. Colonoscopy is the most widely accepted method for colon cancer screening. Early detection and removal of adenomas can significantly reduce risk of colorectal cancer hence; it is of great importance to evaluate the prevalence of colorectal polyps in Egyptian population by diagnostic colonoscopy and associated risk factors. Objective: detect the prevalence of colorectal polyps in Egyptian population and associated risk factors. Patients and Methods: A cross …

Ephedrine Versus Norepinephrine Infusion For Prevention Of Haemodynamic Instability After Declamping Of The Aorta In Abdominal Aortic Aneurysm Repair, Mohamed Younes Yousef Abd Allah, Maha Younes Youssef Abd-Allah, Mohamed E. Elshehawi, Ka Awad

Mansoura Medical Journal

Background: During general anesthesia, hypotension is often experienced and is linked to both postoperative morbidity and death. Anesthesiologists have long had a hurdle while performing abdominal aortic aneurysm (AAA) repair, a high-risk treatment that increases vulnerability to hemodynamic disturbances during open surgery. A common vasopressor that is a combined α- and β-agonist, ephedrine is used to treat hypotension in general anesthesia. Conversely, norepinephrine has a favorable chronotropic impact on the heart in addition to acting as an agonist for both α and ß receptors. Aim of the work: Examine the differences in the effects of intravenous ephedrine hydrochloride and noradrenaline …

Serum Trefoil Factor 3 As A Diagnostic Marker Of Hepatocellular Carcinoma Related To Chronic Hepatitis C Cirrhosis, Mohammed El Hagrasy, Ashraf Omar, Hosam Abdel Twab, Ahmed Saed

Mansoura Medical Journal

Background: Liver cancer, specifically Hepatocellular Carcinoma (HCC), is a main cause of cancer-related deaths globally. Early detection of HCC is also a significant challenge. Our research aimed to examine serum trefoil factor 3 (TFF3) level compared to alpha-fetoprotein (AFP) in diagnosis and prognosis of HCC and other hepatitis C virus (HCV)-related liver diseases. Methods: This single-center prospective study was performed at a Specialized Medical Hospital, Faculty of Medicine, Mansoura University, over a duration of 6 months from May to October 2021. The study consisted of 35 cases with HCC on top of cirrhosis, 35 with HCV-induced cirrhosis, and 20 healthy …

Secondary Traumatic Stress Is An Occupational Hazard For Pet Hospice Support Staff: Psychoeducational Support Groups Provide The Cure, Kari Hayden

DSW Capstone Projects

There are three separate yet interrelated products presented in this final capstone product. The completed product is focused on pet hospice veterinary support staff and the need for an evidence-based social work intervention to combat secondary traumatic stress. This capstone uses the andragogical approach to adult learning theory as the foundation to construct a psychoeducational peer support group specific to this population. Implications for clinical social work in veterinary medicine are presented within this project.

The first scholarly product presented is the Systematic Literature Review (SLR). The SLR utilizes a scoping review process in an attempt to locate prior research …

Pandemic Driven Mobility In Higher Education: The Good, The Bad And The Useful, Orly Calderon, Susan Penque, David Luhr, Caryn Nahum, Lauren Scardigno

Nursing Faculty Publications

The purpose of this mixed method research study is to describe the experiences of faculty and students in post-secondary education institutions as they shifted to remote education at the start of the COVID-19 pandemic, and to understand these experiences in the context of previous research about pre-pandemic remote or mobile education. One hundred and two participants in the study include full-time and adjunct faculty, undergraduate and graduate students. A convergent mixed method survey queried about participants’ demographics, mobility experiences in terms of frequency of access to technology and a suitable learning/teaching environment and usefulness of various web and video conferencing …

Evidence-Based Practice Confidence And Behavior Throughout The Curriculum Of Four Physical Therapy Education Programs: A Longitudinal Study, Wendy Romney, Nancy M. Salbach, Susan B. Perry, Judith E. Deutsch

Physical Therapy Faculty Publications

Background

Evidence-based practice (EBP) is a foundational process taught in health professional education, yet it is unclear when EBP confidence and skills are obtained. Increases in EBP confidence and behaviors from the start of physical therapy programs to post graduation have been reported in studies that evaluated a single program or used non-valid questionnaires. This study aimed to describe changes in EBP confidence and behavior using validated questionnaires of students from four physical therapy education programs throughout their curriculum and one year post graduation.

Methods

One hundred and eighty-one students from a potential pool of 269 (67.3%) consented to participate. …

Long Duration Sonophoresis Of Diclofenac To Augment Rehabilitation Of Common Musculoskeletal Injuries, Paddy Jarit, Dominic Klyve, Rod Walters

Physical Therapy Faculty Publications

Background: The use of long duration sonophoresis (LDS) for musculoskeletal injuries is a new and emerging treatment option for patients undergoing rehabilitation. The treatment is non-invasive, provides multi-hour mechanical stimulus expediating tissue regeneration and deep tissue heat along with local application of therapeutic compound for improved pain relief. The objective of this prospective case study was to evaluate real-world application of diclofenac LDS as an add-on intervention for patients non-responsive to physical therapy alone. Methods: Patient who failed to respond to at least 4 weeks of physical therapy were treated with the addition of 2.5% diclofenac LDS daily for 4 …

Integrative Big Transcriptomics Data Analysis Implicates Crucial Role Of Muc13 In Pancreatic Cancer, Anupam Dhasmana, Swati Dhasmana, Shivangi Agarwal, Sheema Khan, Shafiul Haque, Meena Jaggi, Murali M. Yallapu, Subhash C. Chauhan

School of Medicine Publications

Big data analysis holds a considerable influence on several aspects of biomedical health science. It permits healthcare providers to gain insights from large and complex datasets, leading to improvements in the understanding, diagnosis, medication, and restraint of pathological conditions including cancer. The incidences of pancreatic cancer (PanCa) are sharply rising, and it will become the second leading cause of cancer related deaths by 2030. Various traditional biomarkers are currently in use but are not optimal in sensitivity and specificity. Herein, we determine the role of a new transmembrane glycoprotein, MUC13, as a potential biomarker of pancreatic ductal adenocarcinoma (PDAC) …

Neuro-Ophthalmology Diseases In Elderly, Aishwarya Gatiganti

School of Medicine Publications

It is well understood that as the body begins to age, its ability to adapt and sustain itself decreases. The eyes are not immune to this effect, and the complex interplay between the eyes and the brain deteriorates insidiously over time. There has been a notable increase in the elderly population, and diseases such as the ones described above need to be at the forefront of an ophthalmologist's mind when treating this population. Neuro-ophthalmology diseases in the elderly are not well known to general practitioners but should be included in the differential due to the potential of rapid deterioration and …

Opioid Use Disorder Prediction Using Machine Learning Of Fmri Data, A. Temtam, Liangsuo Ma, F. Gerard Moeller, M. S. Sadique, K. M. Iftekharuddin, Khan M. Iftekharuddin (Ed.), Weijie Chen (Ed.)

Electrical & Computer Engineering Faculty Publications

According to the Centers for Disease Control and Prevention (CDC) more than 932,000 people in the US have died since 1999 from a drug overdose. Just about 75% of drug overdose deaths in 2020 involved Opioid, which suggests that the US is in an Opioid overdose epidemic. Identifying individuals likely to develop Opioid use disorder (OUD) can help public health in planning effective prevention, intervention, drug overdose and recovery policies. Further, a better understanding of prediction of overdose leading to the neurobiology of OUD may lead to new therapeutics. In recent years, very limited work has been done using statistical …

On The Chronological Understanding Of The Homogeneous Dielectric Barrier Discharge, Xinpei Lu, Zhi Fang, Dong Dai, Tao Shao, Feng Liu, Cheng Zhang, Dawei Liu, Chunqi Jiang

Electrical & Computer Engineering Faculty Publications

Dielectric barrier discharges (DBD) are widely utilised non-equilibrium atmospheric pressure plasmas with a diverse range of applications, such as material processing, surface treatment, light sources, pollution control, and medicine. Over the course of several decades, extensive research has been dedicated to the generation of homogeneous DBD (H-DBD), focussing on understanding the transition from H-DBD to filamentary DBD and exploring strategies to create and sustain H-DBD. This paper first discusses the influence of various parameters on DBD, including gas flow, dielectric material, surface conductivity, and mesh electrode. Secondly, a chronological literature review is presented, highlighting the development of H-DBD and the …

Development Of Novel Anticancer Agents Targeting Glioblastoma, Kate Byrne

Theses

Glioblastoma (GBM) is the most common and aggressive malignant grade IV brain tumour. It remains an incurable disease whereby the median survival rate is 15 months and 5.5 % of all patients survive five years post diagnosis. The current therapeutic strategies include the use of maximal safe surgical resection, radiotherapy, and the use of the gold standard chemotherapeutic, Temozolomide (TMZ), which is referred to as the “Stupp Protocol”. Earlier research identified two compounds, which are structurally different but exhibit a similar biological effect to Metformin, the first in-line treatment for type II diabetes. Combining drugs which target cell metabolism such …

An Exploration Of The Causes And Effects Of Interpersonal Conflict Related Stress Among A Self-Selected Cohort Of Second Level Teachers In Ireland, Patrick Bruce

Theses

Teaching has been classified by researchers as a high stress profession. Stress in teaching has been reported to have many negative health outcomes and also affects productivity. The literature also reports that stress in teaching is a difficult matter to resolve satisfactorily, with mixed outcomes from interventions. An emergent cause of work-related stress in education is IPC and this study sets out to investigate the prevalence of this underreported phenomena.

A sample of 25 teachers working in Irish second level schools were recruited. Semi structured interviews were conducted to report on the experiences of stress, it’s causes and effects both …

An Xai Approach For Covid-19 Detection Using Transfer Learning With X-Ray Images, Salih Sarp, Ferhat Ozgur Catak, Murat Kuzlu, Umit Cali, Huseyin Kusetogullari, Yanxiao Zhao, Gungor Ates, Ozgur Guler

Engineering Technology Faculty Publications

The coronavirus disease (COVID-19) has continued to cause severe challenges during this unprecedented time, affecting every part of daily life in terms of health, economics, and social development. There is an increasing demand for chest X-ray (CXR) scans, as pneumonia is the primary and vital complication of COVID-19. CXR is widely used as a screening tool for lung-related diseases due to its simple and relatively inexpensive application. However, these scans require expert radiologists to interpret the results for clinical decisions, i.e., diagnosis, treatment, and prognosis. The digitalization of various sectors, including healthcare, has accelerated during the pandemic, with the use …