Medicine and Health Sciences Commons^™

Program Evaluation Of A Community-Based Model For Driver Off-Road Assessment In Post-Acute Abi, Eugenia R. Herbst

Occupational Therapy Doctorate Capstone Projects

Background: Social conditions from the pandemic forced changes to outpatient rehabilitation programs, necessitating pre-driving assessment be administered via telehealth, an alternative model of OT service-delivery. As a result, Shepherd Pathways adapted the clinical pre-driving program for telehealth service delivery. Program outcomes had not been formally assessed.

Purpose:

The purpose of this Capstone project was to conduct a formal program evaluation to collect, analyze, and use data to evaluate effectiveness and efficiency of a clinical return to drive program delivered via telehealth (CDC, n.d.; The university of Kansas toolbox, n.d.). The program evaluation examined the OT process and scope of services …

Skilled Nuring Facilities Therapists' Experiences With Acquiring Wheelchairs For Their Clients, Vincent Campbell

Occupational Therapy Doctorate Capstone Projects

The United States (U.S.) population is aging resulting in an increase in Skilled Nursing Home (SNF) residents. A larger proportion of SNF residents rely on wheelchairs for mobility. Currently there are no studies that determine the processes, which therapists utilize to correctly fit their clients for wheelchairs. Poor fitting wheelchairs can have a negative impact on the residents’ ability to participate in occupational activities. Residents may also suffer physical or psychological consequences from an ill-fitting wheelchair. Therapists in SNFs often have no established criteria in providing wheelchairs for their clients. There can be institutional barriers to providing appropriate wheelchairs for …

National Children's Dental Health Month Activity Book (2023), American Dental Association Foundation

National Children's Dental Health Month

No abstract provided.

A Case Of Spontaneous Adrenal Hemorrhage In Pregnancy, Benjamin Mallicoat, Kelly Nagy, Christopher Croom

Obstetrics and Gynecology Faculty Publications

A case study looking at a 25 year old patient at 31 weeks gestation with spontaneous adrenal hemorrhage.

Ontario Adults’ Mental Health And Wellbeing During The First 16 Months Of The Covid-19 Pandemicno Title, Katie Shillington, Leigh Vanderloo, Shauna Burke, Victor Ng, Patricia Tucker, Jennifer Irwin

Health Studies Publications

This study quantitatively assessed adults’ mental health and overall wellbeing over time during the first 16 months of the pandemic in Ontario, Canada. A total of 2,188 participants participated in the study and completed online questionnaires at three time points (baseline—April–July 2020; time 2—July–August 2020; and time 3—July–August 2021), which included demographic questions, the Mental Health Inventory (MHI), and the Personal Wellbeing Index-Adult (PWI-A). One-way repeated-measures ANOVAs revealed a statistically significant increase over time in participants’ mental health (MHI), as well as a significant decrease in their satisfaction with their standard of living, physical health, mental health, personal relationships, safety, …

The Opportunity Cost Of Covid For Public Health Practice: Covid-19 Pandemic Response Work And Lost Foundational Areas Of Public Health Work, J. Mac Mccullough, Moriah Robins

Public and Population Health Faculty Publications and Presentations

Context: There is little empirical evidence regarding the magnitude of the COVID-19 response across the public health workforce and the extent to which other public health programs were called upon to contribute to the response, potentially leading to less work being done in other public health programs during the COVID-19 pandemic.

Objectives: To assess the composition of the workforce that contributed to the COVID-19 pandemic response during 2020-2022.

Design: A large, cross-sectional, nationally representative survey of the state and local public health agency workforce through the Public Health Workforce Interest and Needs Survey (PH WINS).

Setting: Nearly all state health …

Concept Of Health-Related Quality Of Life Among People With Heart Failure In Karachi, Pakistan, Anny Ashiq Ali

MBE 2023

Background: Non-communicable diseases (NCDs), including cardiovascular diseases, are a leading cause of global mortality. The mortality rate for cardiovascular diseases is on the rise, with 80 % to 86 % of fatalities, particularly in low- and middle-income countries, including Pakistan. Among NCDs, heart failure (HF) is a condition for which there is no cure, and patients rely on supportive treatments to maintain their quality of life. HF not only affects physical well-being but also has far-reaching consequences on the emotional, social, and cognitive aspects of life. In the context of Pakistan, where unique healthcare, sociocultural, and economic factors prevail, the …

Screening The “Invisible Population” Of Older Adult Patients For Prescription Pain Reliever Non-Medical Use And Use Disorders, Alyssa M. Falise, Vinita Sharma, Carolin C. Hoeflich, Catalina Lopez-Quintero, Catherine W. Striley

Public and Population Health Faculty Publications and Presentations

Background: In the United States, the number of older adults reporting non-medical use of prescription pain relievers (NMUPPR) between 2015 and 2019 has remained constant, while those meeting criteria for opioid use disorders (OUDs) between 2013 and 2018 increased three-fold. These rates are expected to increase due to increased life expectancy among this population coupled with higher rates of substance use. However, they have consistently lower screening rates for problematic prescription pain reliever use, compared to younger cohorts. Objectives: This commentary reviewed trends in older adult NMUPPR and OUDs and reviewed several available screening tools. We then considered …

Synergistic Detrimental Effects Of Cigarette Smoke, Alcohol, And Sars-Cov-2 In Copd Bronchial Epithelial Cells, Abenaya Muralidharan, Christopher Bauer, Dawn M. Katafiasz, Heather M. Strah, Aleem Siddique, St. Patrick Reid, Kristina L. Bailey, Todd A. Wyatt

Journal Articles: Environmental, Agricultural & Occupational Health

Lung conditions such as COPD, as well as risk factors such as alcohol misuse and cigarette smoking, can exacerbate COVID-19 disease severity. Synergistically, these risk factors can have a significant impact on immunity against pathogens. Here, we studied the effect of a short exposure to alcohol and/or cigarette smoke extract (CSE) in vitro on acute SARS-CoV-2 infection of ciliated human bronchial epithelial cells (HBECs) collected from healthy and COPD donors. We observed an increase in viral titer in CSE- or alcohol-treated COPD HBECs compared to untreated COPD HBECs. Furthermore, we treated healthy HBECs accompanied by enhanced lactate dehydrogenase activity, indicating …

Self-Reported Respiratory Health Symptoms And Respiratory Protection Behaviors Of Young Adult Hog Producers In The United States, Jenna L. Gibbs, Carolyn Sheridan, David Sullivan, Risto Rautiainen, Matthew W. Nonnenmann, Todd A. Wyatt

Journal Articles: Environmental, Agricultural & Occupational Health

INTRODUCTION AND METHODS: In this study, we evaluated self-reported respiratory symptoms during agricultural work, respiratory protection use and experience, and perceived value of receiving respirators using Gear Up for Ag Health and Safety Program™ pre- and post-surveys from 703 to 212 young adult hog producers in the United States. To our knowledge, this is one of the most extensive survey data sets on self-reported respiratory symptoms and respiratory protection behaviors of collegiate-aged young adults working in US livestock production.

RESULTS: About one-third (37%) of young adult hog producers stated that they have experienced cough, shortness of breath, fever, and chills …

Human Alcohol-Microbiota Mice Have Increased Susceptibility To Bacterial Pneumonia, Kelly C. Cunningham, Deandra R. Smith, Daniel Villageliu, Christi M. Ellis, Amanda E. Ramer-Tait, Jeffrey D. Price, Todd A. Wyatt, Daren L. Knoell, Mystera M. Samuelson, Patricia E Molina, David A. Welsh, Derrick R. Samuelson

Journal Articles: Environmental, Agricultural & Occupational Health

Preclinical studies have shown that chronic alcohol abuse leads to alterations in the gastrointestinal microbiota that are associated with behavior changes, physiological alterations, and immunological effects. However, such studies have been limited in their ability to evaluate the direct effects of alcohol-associated dysbiosis. To address this, we developed a humanized alcohol-microbiota mouse model to systematically evaluate the immunological effects of chronic alcohol abuse mediated by intestinal dysbiosis. Germ-free mice were colonized with human fecal microbiota from individuals with high and low Alcohol Use Disorders Identification Test (AUDIT) scores and bred to produce human alcohol-associated microbiota or human control-microbiota F1 progenies. …

Novel Analysis Of The Sars-Cov-2 Genome To Identify Positive Evolutionary Selection In The Spike Protein Of Emerging Variants, Ulysses Ison

Browse all Theses and Dissertations

This thesis tests the hypothesis that the spike protein of SARV-CoV-2 is under positive evolutionary selection. A consensus nucleotide sequence was generated for the most current SARS-CoV-2 variant, XBB1.5, by performing sequence alignments of recent isolates. The consensus nucleotide sequence was translated to obtain the amino acid sequence. The amino acid and nucleotide sequences were compared to the original Wuhan-hu-1 strain to identify mutations. Forty-three mutations were identified in the spike protein, and all but two changed the amino acid. The majority of mutations were found in the receptor binding domain of the spike protein, which is the region of …

Addressing Disparity: A Waiting Room Intervention For Preeclampsia Prevention In African Americans, Morgan Semana

Nursing | Student Research Posters

No abstract provided.

Lived Experiences Of People With Substance Use Disorder As Healthcare Education To Develop Empathy For This Population, Whitney Bynum

Nursing | Student Research Posters

Stigmas that develop among healthcare workers regarding patients with substance use disorder include: "drug-seeking", "violent", and "unmotivated". These beliefs can decrease the quality of care provided and results in less people seeking out needed treatment. Healthy People's 2030 goals include reducing drug and alcohol addiction. In order to do this, healthcare workers need to show empathy and form trusting relationships with this patient population. Building a trusting relationship allows the patient to be more receptive to help and suggestions. Learning the life story of a patient can help healthcare workers develop empathy and reduce negative attitudes.

Perspective Of Patients And Stakeholders As Members Of A Research Team, Janet L Poole, Sharon L Newbill

Pediatrics Research and Scholarship

Systemic sclerosis (SSc) is a rare orphan disease, characterized by skin thickening, vascular insufficiency, and fibrosis of internal organs. SSc affects about 100,000 people in the United States. This study explored perceived benefits and challenges of patient partners and stakeholders, who were team members on a project to revise and test a self-management program (Taking Charge of Systemic Sclerosis). Five patient partners, 1 stakeholder from the Scleroderma Foundation and 1 stakeholder from a state chapter of the Scleroderma Foundation were interviewed. Conversations were audio recorded and transcribed verbatim and analyzed. Four themes emerged from the analysis with corresponding subthemes: contributions …

A Systematic Literature Review Of Research From 2010 To 2020 Addressing User-Generated Online Comments Related To Health Issues And Recommendations For Future Research, Muhammad Ittefaq, Mauryne Abwao, Ioana A. Coman, Waqas Ejaz

School of Communication Studies - Faculty Scholarship

This systematic literature review was conducted to provide insights into how online readers’ comments have been studied in the context of health over a 10-year span. About 593 studies published between 2010 and 2020; of these, 34 met the research criteria for inclusion. Our findings reveal that 60% of the studies focused on the United States, and a qualitative method was used in 74.3% of these studies. About 23.5% of the studies explored vaccine-related issues. Our results reveal that among the selected studies, 76.5% and 20.6% had female and male first authors, respectively. Textual analysis of abstracts shows that the …

4 - Special Pathogens Lab, Providence - Special Pathogens Program

Special Pathogens Posters

No abstract provided.

Prevention Research Center For Healthy Neighborhoods, Madeline Panus

Celebration of Scholarship 2023

No abstract provided.

Imi—Management And Investigation Of High Myopia In Infants And Young Children, Daniel Ian Flitcroft, John Ainsworth, Audrey Chia, Susan Cotter, Elise Harb, Zi-Bing Jin, Caroline C. W. Klaver, Anthony T. Moore, Ken K. Nischal, Kyoko Ohno-Matsui, Evelyn A. Paysse, Michael X. Repka, Irina Y. Smirnova, Martin Snead, Virginie J. M. Verhoeven, Pavan K. Verkicharla

Articles

The purpose of this study was to evaluate the epidemiology, etiology, clinical assessment, investigation, management, and visual consequences of high myopia (≤−6 diopters [D]) in infants and young children.

Imi—Nonpathological Human Ocular Tissue Changes With Axial Myopia, Jost B. Jonus, Richard F. Spaide, Lisa A. Ostrin, Nicola S. Logan, Daniel Ian Flitcroft, Songhomitra Panda-Jonas

Articles

In axial myopia, the eye changes from a spherical shape to a prolate ellipsoid, photoreceptor, and retinal pigment epithelium cell density and total retinal thickness decrease, most marked in the retroequatorial region, followed by the equator. The choroid and sclera are thin, most markedly at the posterior pole and least markedly at the ora serrata. The sclera undergoes alterations in fibroblast activity, changes in extracellular matrix content, and remodeling. Bruch’s membrane (BM) thickness is unrelated to axial length, although the BM volume increases. In moderate myopia, the BM opening shifts, usually toward the fovea, leading to the BM overhanging into …

Imi 2023 Digest, Padmaja Sankaridurg, David A. Berntsen, Mark A. Bullimore, Pauline Cho, Daniel Ian Flitcroft, Timothy J. Gawne, Kate Gifford, Monica Jong, Lisa A. Ostrin Lisa A. Ostrin, Jacinto Santodomingo-Rubido, Christine Wildsoet, James S. Wolffsohn

Articles

Myopia is a dynamic and rapidly moving field, with ongoing research providing a better understanding of the etiology leading to novel myopia control strategies. In 2019, the International Myopia Institute (IMI) assembled and published a series of white papers across relevant topics and updated the evidence with a digest in 2021. Here, we summarize findings across key topics from the previous 2 years. Studies in animal models have continued to explore how wavelength and intensity of light influence eye growth and have examined new pharmacologic agents and scleral cross-linking as potential strategies for slowing myopia. In children, the term premyopia …

Modification Of Hyaluronic Acid To Enable Click Chemistry Photo-Crosslinking Of Hydrogels With Tailorable Degradation Profiles, Ciara Buckley

Articles

Hyaluronic acid (HA) is a naturally occurring mucopolysaccharide that, due to its inherent bioactivity and extracellular matrix-like structure, has the potential to be utilised extensively in tissue engineering. However, this glycosaminoglycan lacks the properties required for cellular adhesion and photo-crosslinking by UV light, which significantly hinders this polymers applicability. This research presents a method for modifying hyaluronic acid via thiolation and methacrylation to generate a novel photo-crosslinkable polymer with improved physicochemical properties, biocompatibility and the potential to customize biodegradability according to the ratio of monomers used. A decrease in stiffness proportional to increasing thiol concentration was observed when testing the …

Reliability, Usefulness, And Validity Of Field-Based Vertical Jump Measuring Devices, Thomas M. Comyns, Jennifer Murphy, Dylan O'Leary

Articles

Comyns, TM,Murphy, J, and O’Leary, D. Reliability, usefulness, and validity of field-based vertical jump measuring devices. J Strength Cond Res 37(8): 1594–1599, 2023—The purpose of this study was to examine the test-retest reliability, usefulness, and validity of field based devices, in determining jump height (JH) during a countermovement jump (CMJ). Twenty-one male (22.8 6 2.4 years; 1.82 6 0.07m; 86.0610.4 kg) and 7 female field sport athletes (20.561.5 years; 1.6560.06 m; 65.467.2 kg) performed 3CMJs with data simultaneously recorded using a force plate (criterion measure), Opto jump, Output Capture, and Push-Band 2.0. Reliability was determined by intraclass correlation (ICC) and …

“They'll Take A Gun To Me Before I Get That Shot”:Rationalization, Emotions, And Misinformation In Covid-19 Vaccine Hesitancy, Michaela George, Benjamin Rosenberg, Savannah N. Dale, Lauren H. Kirkland, Patti L. Culross, Rong Chen

Psychology | Faculty Scholarship

Vaccine hesitancy—the reluctance, delay, or refusal tovaccinate regardless of availability—is not a new concept inpsychology, medicine, or public health. However, given theemotions surrounding the COVID-19 vaccine, hesitancy hasproven difficult to overcome. To date, the bulk of availabledata on vaccine hesitancy are quantitative, leaving room forexploratory investigations into the reasons adults remainunvaccinated. This qualitative study assessed the moti-vations, beliefs, and perceptions of individuals who havedecided to remain unvaccinated against COVID-19. We hadone exploratory research question: What social psychological justifications emerge from vaccine hesitant people'sexplanations of their decisions to remain unvaccinated?To assess this question, we conducted 18 interviews withunvaccinated adults throughout 2021–2022. …

Well-Being In Graduate Health Professions Education: Exploration Of Programmatic Interventions, The Student Experience, And Students’ Support Preferences, Katherine Schultz

Graduate Research Theses & Dissertations

Healthcare provider well-being is a growing area of professional concern. Beyond the negative impacts on the clinicians’ health, stress, burnout, and other manifestations of decreased clinician well-being can directly affect the quality of patient care. Research suggests that well-being concerns begin in graduate health professions education programs, during which students undergo rigorous academic and clinical training for future careers as clinicians. The aim of this study was to explore programmatic interventions to promote well-being in graduate health professions education and the students’ experiences of well-being while enrolled in graduate health professions programs.

This study was conducted across three phases. Phase …

Investigating Novel Ispe Inhibitors Of The Mep Pathway In Mycobacterium, Seoung Ryoung Choi, Prabagaran Narayanasamy

Journal Articles: Pathology and Microbiology

In a recent effort to mitigate harm from human pathogens, many biosynthetic pathways have been extensively evaluated for their ability to inhibit pathogen growth and to determine drug targets. One of the important products/targets of such pathways is isopentenyl diphosphate. Isopentenyl diphosphate is the universal precursor of isoprenoids, which are essential for the normal functioning of microorganisms. In general, two biosynthetic pathways lead to the formation of isopentenyl diphosphate: (1) the mevalonate pathway in animals; and (2) the non-mevalonate or methylerythritol phosphate (MEP) in many bacteria, and some protozoa and plants. Because the MEP pathway is not found in mammalian …

Accelerated Sars-Cov-2 Intrahost Evolution Leading To Distinct Genotypes During Chronic Infection, Chrispin Chaguza, Anne M. Hahn, Mary E. Petrone, Shuntai Zhou, David Ferguson, Mallery I. Breban, Kien Pham, Mario A. Peña-Hernández, Christopher Castaldi, Verity Hill, Yale Sars-Cov-2 Genomic Surveillance Initiative, Wade Schulz, Ronald I. Swanstrom, Scott C. Roberts, Nathan D. Grubaugh, Kendall Billig, Rebecca Earnest, Joseph R. Fauver, Chaney C. Kalinch, Nicholas Kerantzas, Tobias R. Koch, Bony De Kumar, Marie L. Landry, Isabel M. Ott, David Peaper, Irina R. Tikhonova, Chantal B. F. Vogels

Journal Articles: Epidemiology

The chronic infection hypothesis for novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant emergence is increasingly gaining credence following the appearance of Omicron. Here, we investigate intrahost evolution and genetic diversity of lineage B.1.517 during a SARS-CoV-2 chronic infection lasting for 471 days (and still ongoing) with consistently recovered infectious virus and high viral genome copies. During the infection, we find an accelerated virus evolutionary rate translating to 35 nucleotide substitutions per year, approximately 2-fold higher than the global SARS-CoV-2 evolutionary rate. This intrahost evolution results in the emergence and persistence of at least three genetically distinct genotypes, suggesting …

January 2023, New England Osteopathic Heritage Center

New England Osteopathic Heritage Center Newsletter

New England Osteopathic Heritage Center's annual newsletter for January 2023

Severity And Operative Age In Metopic Synostosis: The Association With Neurocognitive Outcomes, Aaron Samuel Long

Yale Medicine Thesis Digital Library

The cranial morphology of single-suture metopic craniosynostosis is defined by trigonocephaly, hypotelorism, and bitemporal narrowing. The severity of deformity may be defined radiographically based on computed tomography imaging. The radiographic severity of metopic synostosis has been suggested as a possible predictor of long-term neurocognitive outcomes, making it a potentially useful variable in determining which patients will benefit from surgery. Artificial intelligence (AI) has recently been used to quantify severity of metopic synostosis. Furthermore, age at surgery has been shown predict long-term neurocognition in sagittal synostosis but has not been adequately explored in metopic synostosis. In sagittal synostosis, age at surgery …

Adherence To Tumor Board Recommendations In Patients With Hepatocellular Carcinoma, Yueming Cao

Yale Medicine Thesis Digital Library

Hepatocellular carcinoma (HCC) is a heterogeneous disease that typically arises in the setting of chronic liver disease, making treatment selection complex. Multidisciplinary liver tumor boards (MDLTB) have been shown to improve outcomes in patients with HCC. However, in many cases, patients evaluated by MDLTBs ultimately do not receive the board’s recommended treatment. In this paper, we performed a single-site, retrospective cohort study of patients with HCC who were evaluated by an MDLTB. We examined adherence to the MDLTB’s recommendations and in cases of discordant treatment, evaluated the underlying cause. We found that most patients’ therapies were adherent to the MDLTB’s …