Medicine and Health Sciences Commons^™

Investigation Of Dosing Interval Differences For Nepafenac Ophthalmic Suspensions: A Suspension-Specific Pbpk Model With Improved In Vitro Dissolution Data, Xu Sun

Selected Full-Text Dissertations 2020-

Nepafenac is a nonsteroidal anti-inflammatory drug (NSAID) for the treatment of inflammation associated with cataract surgery. It is marketed as two ophthalmic suspensions—NEVANAC® (0.1% administered three times a day) and ILEVRO® (0.3% administered once a day). The primary mediator of pain relief is amfenac, which is a metabolite of nepafenac. The primary goal of this project was to explain how was the dosing interval affected by changes in formulation properties. The approach incorporated three novel elements. 1) A physiologically based pharmacokinetic (PBPK) model that is specific to this application for nepafenac and amfenac was constructed, which allowed tracking the specific …

The Use Of Culturally Sustaining Practices In Play To Foster Resilience, Genevieve Lowry

Graduate School of Education

Children present in the hospital with an array of previous experiences. Play specialists must learn to help children use experiences as opportunities for growth and coping and be prepared when significant life events emerge as part of a child's play. Ecological models provide a framework for understanding children's lived experiences affecting development and offering insight into children and families responses to stress. Foundational theories of play provide knowledge of children's development, interests, and understanding of themselves and the world. This chapter examines two culturally sustaining models that build on play theories viewing children and families through a strengths-based lens that …

Play's Continuum Of Needs: Building Blocks For Deepening Play Opportunities In Medical Environments, Deborah Brewster Vilas

Graduate School of Education

Optimal healing for children in hospitals occurs when their developmental needs are considered as part of their overall treatment plan. One of the most pressing developmental needs for all children is the need to play, and this remains so even when they are confined to a hospital bed or face developmental delays or disabilities. This chapter examines the most basic components of implementing play programs in hospitals, such as the intentional creation of space for play, determining the best times for children to play, and exploring what types of play are therapeutic and possible in a hospital environment. The author …

Achilles Tendon Stiffness Of Division 1 Track And Field Athletes, Erin Luken Spt, Sydney Gustaf Spt, Jessica Thum, Drew Peters Spt, Jason Polzin

Physical Therapy Student Research Projects

Background: No previous research provides data on Achilles tendon (AT) stiffness of Division 1 (D1) track and field (TF) athletes. Limited information is known on what variables influence tendon stiffness in athletes. AT stiffness may have an impact on injury and performance in D1 TF athletes, warranting research. The purpose of this study is to identify if there are factors that correlate with AT stiffness among D1 TF athletes.

Methods: Fifty-one D1 TF athletes voluntarily participated in a cross-sectional study of AT biomechanical measurements at the beginning of the fall season. The MyotonPro was used for measurements at the midline …

Correlation Of Various Heart Rate Measures And Borg Cr10 Ratings Within The First Five Minutes Of Moderate- And Vigorous-Intensity Exercise, Maia Janae Gabrielson Spt, Maddison Elizabeth Hajek Spt, Kiana Lynn Hoff Spt, Rachel Marie Schmitz Spt, Jamie Lynn Schweiss Spt

Physical Therapy Student Research Projects

Aerobic exercise is a crucial component of an individual’s health regimen. Target heart rate (HR), using HR, percentage of maximum HR, or percentage of HR reserve offers an objective manner to gauge exercise intensity. Rate of perceived exertion (RPE) using either the traditional or modified scale (Borg CR10) offer a subjective option for measuring individual exercise intensity. The purpose of this research study was to investigate the relationship of various HR measures with subjective report of exercise intensity via the Borg CR10 scale during the first five minutes of exercise geared towards moderate and vigorous intensity. Thirty-four college-aged participants completed …

The Effects Of Balance Exercises On Lower Extremity Injury Prevention: A Systematic Review, Madason Gene Leif Spt, Bailey James Neises Spt, Zach Thomas Sebern Spt, Ryan John Hanks Spt

Physical Therapy Student Research Projects

Background: Previous systematic reviews have identified injury risk predictors of sport-related lower extremity (LE) injuries based on exercise programs. There are limited studies indicating the advantage of single-leg balance (SLB) training and its effectiveness in lowering injury rates. Research Question: Investigate which types of balance training were used in effective injury prevention programs. Methods: A systematic review utilizing the SPORTDiscus and PubMed databases. Inclusion criteria were randomized controlled trials from the last 10 years that included LE injury prevention, a balance training component and participants aged 10-30. Results: 5 studies were included in the qualitative synthesis, comprising 2,926 athletes. Three …

Knowledge, Awareness, And Intercultural Communication Effectiveness Among Us And Egyptian Student Physical Therapists Following An Educational Intervention, Jordyn Ann Bernstein Spt, Alysa Nichole Gregg Spt, Jessica Deanne Schmidt Spt

Physical Therapy Student Research Projects

Widespread technology has enhanced international collaboration opportunities. In healthcare professions, communication amongst different cultures is an essential skill to help professionals excel in diverse clinical settings. Physical Therapy programs in the US address the need for cultural competence with classroom activities, but direct interactions with student physical therapists (SPTs) from differing countries are rare. The goal of the study was to investigate changes in intercultural communication effectiveness among US and Egyptian SPTs following four educational sessions. Each session featured an educational video about aspects related to physical therapy in each country and was followed by small group discussions, during which …

A Cross-Sectional Cohort Of The Healthy Older Adult Population’S Ability With Left Right Judgment Task, Cody Jay Davis Spt, Aleesha Kristine Kreutzfeldt Spt, Ali A. Kuca Spt, Whitney Anne Smith Spt, Bailey Marie Volmer Spt

Physical Therapy Student Research Projects

Over 100 million US adults suffer from chronic pain, many older adults. In some cases, chronic pain has been shown to alter a person’s body schema and thus their motor imagery ability. Clinically, a measurement of left/right judgment (LRJ) has been used to measure motor imagery. Evidence suggests differences can be found in individuals’ LRJ reaction times and accuracy for those with pain compared to those without. Limited study has been done in the area of LRJ in an older population. The primary objective of this study is to explore LRJ norms for older adults. The secondary aim is to …

What’S All The Racket? Comparing Physical Health Outcomes Between Pickleball And Tennis In Older Athletes, Megan Doneen Wilson Spt, Ashley Nicole Meldrum Spt, Austin Jeffrey Buchholz Spt, Andrew David Taverna Spt, Michael John Olson Spt

Physical Therapy Student Research Projects

Background: Pickleball is rising in popularity, especially among older adults. Pickleball boasts psychological and physical benefits to aging athletes. Singles pickleball has been found to approximate brisk walking in metabolic equivalents (METs) at 4.1, while the METs level for singles tennis is 7.0-8.0. The physical health benefits of tennis are known to be positive while those of pickleball are still being explored. With objective differences in MET level it may be surmised that health outcomes might vary between the two sports.

Purpose: The purpose of this study was to use the Senior Athlete Fitness Exam (SAFE) to quantify and compare …

Impact Of Perfectionism, Social Media, And Sleep Hygiene, On Stress In Students From Health Professions Programs, Dayton Duane Braley Spt, Madisyn Ann Dingmann Spt, Brooke Elizabeth Grussing Spt, Justin Daniel Heinrichs Spt, Trystin Renae Nilson Spt

Physical Therapy Student Research Projects

Title: Impact of Perfectionism, Social Media, and Sleep Hygiene, on Stress in Students from Health Professions Programs

Purpose: Explore the impact and relationships of perfectionism, sleep, and social media on stress in health profession students.

Methods: After IRB approval, 62 health pre-professional/professional students completed this non-experimental survey via Qualtrics. The survey consisted of the Perceived Stress Scale (PSS), Frost Multidimensional Perfectionism Scale (FMPS), Pittsburgh Sleep Quality Index (PSQI), questions about social media usage, and demographic characteristics. Surveys were completed in 2021.

Results: Participant demographics included: 50 female, 12 male; Mean Age (24.16); Program of Study (23 PT, 9 OT, 13 …

Accelerated Onboarding For Unlicensed Personnel When Preceptors Are Limited, Britney Winkelman

Nursing Posters

Problem:

The timeframe between hiring unlicensed personnel (UP) to beginning the role within the organization began to increase due to limited orientation resources, rising staff shortages, and insufficient number of preceptors.

Purpose:

Accelerate the onboarding of UPs to decrease the workload for preceptors and reduce staff shortages, while generating competence and reducing costs for the organization.

Clinical Nurse Specialists: A Rare Breed, Teresa Jahn, Evalyn Michira, Elizabeth Plante

Nursing Posters

What is a CNS?:

• A clinical nurse specialist (CNS) is an advanced practice registered nurse (APRN) with graduate level education in nursing.
• CNSs are prepared to provided leadership, consultation, and clinical expertise for patients and their families, nurses, and systems.
• Have the autonomy to diagnose and treat based on advanced clinical assessment like other APRNs (Nurse practitioners, certified nurse midwives, certified registered nurse anesthetists).
• CNS work in all areas of healthcare like clinics, emergency departments, hospital units, entire healthcare systems, or even as independent practitioners/contractors.

Icu Cauti Incidence Reduction, Michelle Gamble

Nursing Posters

Situation:

Catheter-Associated Urinary Tract Infection (CAUTI) rates in the adult Intensive Care Unit (ICU) increased from nine infections in FY21 to 18 in FY22.

Backgroud:

CAUTIs are the most reported healthcare acquired infection. It is important for healthcare providers to understand the complications and effects of CAUTIs. CAUTIs contribute to extended length of stay, increased healthcare costs, and patient morbidity and mortality.

Most CAUTIs are directly related to inadequate urinary catheter care. Evidence based practice demonstrates a decrease in CAUTIs related to the use of Theraworx^® Protect wipes twice daily (BID) and as needed (PRN) for patients with a …

Pupillometry, Elizabeth Plante, Casey Schmidt

Nursing Posters

Background:

• Measuring pupillary light reflex is a standard part of neurological assessment.
• Changes in pupil reactivity may indicate unfavorable outcomes, such as increased intracranial pressure and brain herniation.
• Physiologic and pharmacologic agents may affect pupil reactivity.
• In some instances, pupillary light reflex is the only piece of neurologic assessment readily testable.

What I Need: Self Care At The Unit Level, Jessica A. Tindal

Nursing Posters

Purpose:

Self-care is individualized and best done when awarded on a small scale.

Goals:

For all employees of the ICU to:

• Feel valued outside of work
• Be recognized for taking care of themselves
• Participate in positive discussions
• Be rewarded for work life balance
• Be reminded of self-care
• Not feel alone with their thoughts
• Pause and reflect
• Help others, spouses, kids, etc.

Future plans include:

• Seasonal questions of things to see, places to explore
• Recipe sharing
• Hobby experts
• Focusing on staffs' interests

Safe Intra-Hospital Transport Of Adult Patients On Non-Critical Care Units, Teresa Jahn, Janelle Maciej, Greta Titus

Nursing Posters

Plan:

Between 2021 and 2022, two non-critical adult patients returning from the imaging department after an invasive procedure developed increased oxygen needs, which ended in death for on patient and a transfer to critical care for the other.

No formal guidelines exist for the intra-hospital transport by unlicensed personnel may be absent. An intra-hospital transport checklist was developed for non-critical care patients leaving the unit for procedures in the imaging department.

Do:

• A "RN Pre-Invasive Procedure Transport Safety Checklist" was created by a telemetry RN (MSN student, Greta Titus) and CNS, Teresa Jahn
• The checklist was designed to answer questions …

Transitions To Normal Saline Only For Cvads, Megan Lehn, Ann Backes

Nursing Posters

Purpose Statement:

The purpose of this project is to implement a practice change throughout the system to remove heparin flushes for Central Venous Access Devices (CVADS) pending a successful pilot on Medical Oncology.

Synthesis of Evidence:

• Shama et al (2019) conducted a systematic review and meta-analysis including 886 participants that revealed no clear differences in CVC patency between heparin and NS.
• Klein et al (2018) conducted a pilot study on a 30-patient bone marrow transplant unit, each patient had a new CVC and were divided into two groups. Among 698 catheter-associated events overall incidence of central line issues were similar …

Importance Of Eye Exams As A Secondary Preventative Measure For Diabetic Retinopathy: Winning The War On Blindness, Alondra S. Arredondo, Olivia Demeyer, Rachel Louise Pfenning-Wendt, Samuel Wolfe

All Electronic Theses and Dissertations

Despite current efforts by medical professionals to reduce the prevalence of diabetic retinopathy (DR), a microvascular complication of uncontrolled diabetes, this noncommunicable disease remains the leading cause of preventable vision loss worldwide (Cheloni et al., 2019). Research estimates 90% of DR cases could be prevented if detected early through routine eye exams, yet certain social determinants of health still remain a significant barrier for many individuals to receive this care. According to Wong & Sabanayagam (2020), only 25% of DM patients in developing countries receive routine care with adequate eye screenings. The goal of this community service project was to …

Rural Maternal Care Crisis & Strained Workforce: An Integrative Review Revealing Factors In The Rural Maternal Care Crisis, Taylor F. High Elk

All Electronic Theses and Dissertations

Introduction: The United States is comprised of 75% rural areas and settings (American College of Obstetricians and Gynecologists (2014). Nearly five million women in the US do not have access to maternity care in the county in which they reside (Uribe-Leitz et al., 2022). Purpose: The purpose of this integrative review is to assess the hospitals that provide maternity care in rural settings, the procedures performed in these locations, and the maternal care workforce in the rural obstetric setting. The goal of this research is to identify why there is a lack of maternity care in the rural setting, and …

Exploring Occupation-Based Sleep Interventions For School-Aged Children Experiencing Homelessness: A Critically Appraised Topic, Aspen Delano, Joslynn Sauer, Emily Vieth

Critically Appraised Topics

Sleep is a crucial component of healthy neurological development throughout childhood. According to Suni (2023a), elementary school-aged children between the ages of 6 and 12 experience sleep deprivation when they obtain less than 9 hours of sleep per night. Contie (2022) found that children experiencing insufficient sleep had more mental health and behavioral challenges than those who had sufficient sleep. Additionally, Contie (2022) found that children experiencing sleep deprivation had less gray matter and volume in their brains. This impacts cognitive functioning, specifically decision-making, conflict-solving, working memory, and learning. The brain undergoes critical development of the basal ganglia, ganglia-thalamus-cortex circuit, …

Occupational Therapy’S Role In Natural Disasters, Olivia A. Dobrinz, Elise N. Gapp, Jocelyn R. Kirk

Critically Appraised Topics

This critically appraised topic paper (CAT) focuses on interventions for improving individuals’ quality of life and occupational participation following a natural disaster. Described within this CAT are the impacts on individual’s occupations following a natural disaster, the quality of life for individuals, and occupational therapy’s role in improving an individual’s quality of life and occupational participation.

Leukocytes As Mediators Of Gut-Brain Communication, Dilini Ekanayake

Biomedical Sciences Posters and Presentations

Food allergies

▪ Reactions range from mild/delayed to severe/rapid. ▪ People with mild allergic reactions have increased re-exposure risks. ▪ Cow’s milk allergy tends to manifest with milder allergic reactions.

Cow’s milk allergy (CMA)

▪ CMA has been associated with behavioral and neurological disorders. ▪ How allergic inflammatory signals from the gut reach the brain is unclear

Continuous Consumption Of Whey Protein Affects Motor And Cognitive Functions In A Mouse Model Of Cow’S Milk Hypersensitivity, Geetika Verma

Biomedical Sciences Posters and Presentations

Hypersensitization to a food allergen can occur in the absence of immediate allergic reactions, a condition referred to as asymptomatic sensitization. Using mice asymptomatically sensitized to a bovine whey allergen, β-lactoglobulin (BLG, Bos d 5), we have previously shown that chronic exposure to the allergen results in behavior changes with increased neuroinflammation and cortical demyelination. However, whether allergen avoidance can resolve these pathologies is unknown. Thus, we aimed to compare immunological and behavioral changes in sham- or BLG-sensitized mice with or without the removal of dietary whey after the mice had consumed either a control diet (CTL) or a whey-protein-containing …

Continued Food-Allergen Consumption Exacerbates Beta-Amyloid Accumulation In Allergen-Sensitized Appnl-G-Fmice., Afrina Brishti

Biomedical Sciences Posters and Presentations

Alzheimer’s disease (AD) is the most common neurodegenerative disease, with β-amyloid(Aβ) plaque deposition being one of the hallmark pathologies. However, the etiology of AD remains elusive. While chronic inflammation from recurrent infections or injury seems to contribute to AD development, it is unclear whether atopic diseases, such as allergies, are associated with AD. We previously reported that continuous consumption of a whey protein(WP) -containing diet led to lasting neuro inflammation in C57BL/6J mice that were sensitized but tolerant to a bovine milk allergen, β-lactoglobulin (BLG;Bosd5). Thus, we hypothesized that the persisting neuroinflammation due to repeated allergen consumption would exacerbate AD …

New England Osteopathic Association: Constitution, New England Osteopathic Association

John McPartland, D.O. Collection

Constitution of the New England Osteopathic Association organized in Boston January 28, 1905.

Vermont State Association Of Osteopathic Physician And Surgeons Inc.: Correspondence Soliciting New D.O.S To Vermont, Vermont State Association Of Osteopathic Physicians And Surgeons Inc.

John McPartland, D.O. Collection

A letter from the Vermont State Association of Osteopathic Physicians and Surgeons, Inc. soliciting D.O.s to move to Vermont.

Nefom: Board Of Trustees: Corporation Members, New England Foundation For Osteopathic Medicine

William Kirmes, D.O. Collection

List of NEFOM corporation members, undated.

New England Osteopathic Assembly: Maxwell To Kirmes, R. E. Maxwell D.O.

William Kirmes, D.O. Collection

A short handwritten personal note from Dr. R.E. Maxwell to Dr. Kirmes arranging their trip to the New England Osteopathic Assembly meeting.

New Hampshire Osteopathic Association: Dr. Kirmes To Potential New Hampshire D.O.S, William Kirmes D.O.

William Kirmes, D.O. Collection

A letter from Dr. Kirmes to potential New Hampshire D.O.s recommending coming to New Hampshire to practice.

Strategies To Improve Patient Compliance Regarding Smoking Cessation, Genevieve R. Benzinger, Lydia Burton

Dental Hygiene Student Scholarship

Exposure to cigarette smoke in the oral cavity alters the function of key periodontal pathogens such as P. gingivalis, promoting biofilm formation, colonization, and infection. The purpose of this review is to investigate how improved education on smoking can decrease negative oral health risks. Education amongst healthcare professionals and their patients is positively correlated to smoking cessation.

Smoking counseling has been shown to be more effective when given by multiple healthcare professionals outside of and in addition to primary care. Evidence shows that the chances of breaking smoking habits increase as smoking cessation counseling, cost-free medications, and follow up visits …