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2023

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Full-Text Articles in Medicine and Health Sciences

Job Demands Of Occupational Therapy Clinical Placements: A Descriptive Study Using The Practicum Demands Measure©, Behdin Nowrouzi-Kia, Donna Barker, Jill Stier, Joyce Lo Jan 2023

Job Demands Of Occupational Therapy Clinical Placements: A Descriptive Study Using The Practicum Demands Measure©, Behdin Nowrouzi-Kia, Donna Barker, Jill Stier, Joyce Lo

The Open Journal of Occupational Therapy

The purpose of this study was to group and analyze the Practicum Demands Measure© (PDM) data collected over 2 academic years and create a general profile of demands across practicum settings. The data will be used to guide faculty in the most suitable placement of students requiring accommodations for a disability. The study used a secondary analysis design to analyze the 538 participant PDM data collected over the 2017/2018 and 2018/2019 academic years. Most of the sampled students were in fieldwork Level I and worked in mental health settings. The students reported physical demands, such as lifting more …


Implementation Of A Human Trafficking Educational Module For College Students: Pre/Post Design, Kristen Hill, Patti T. Calk, Erin Bradley, Ross E. Hunt, Maria C. Lauer, Danielle R. Lee, Casi E. Martin, Christy M. Stillwell Jan 2023

Implementation Of A Human Trafficking Educational Module For College Students: Pre/Post Design, Kristen Hill, Patti T. Calk, Erin Bradley, Ross E. Hunt, Maria C. Lauer, Danielle R. Lee, Casi E. Martin, Christy M. Stillwell

The Open Journal of Occupational Therapy

This research study aimed to implement an educational module and to determine the effectiveness of that module on increasing the awareness of human trafficking and risk factors for incoming freshman students at a medium-size, Southern university from September 2021 through November 2021. Two hundred students consented and participated in the study by completing the pretest and posttest to indicate their knowledge of human trafficking before and after being presented an online educational module. The pre and posttest included 10 questions with 24 possible responses. An average of 12.34 correct responses were provided on the pretest and 19.13 were correct responses …


A Narrative Review Of Student Evaluations Of Teaching In Decolonial Praxis: Implications For Occupational Therapy Higher Education, Fatima Hendricks, Michaele Singleton, Asia Clark, Marina Mishin, Marissa Epps Jan 2023

A Narrative Review Of Student Evaluations Of Teaching In Decolonial Praxis: Implications For Occupational Therapy Higher Education, Fatima Hendricks, Michaele Singleton, Asia Clark, Marina Mishin, Marissa Epps

The Open Journal of Occupational Therapy

Student evaluations of teaching (SETs) are the primary source for evaluating teaching effectiveness and are used for deciding tenure and promotion. However, as efforts to engage in a decolonial critique of higher education amplify, the use of SETs in teaching and learning requires scrutiny. A narrative review was used to address the research question of SET biases in decolonial praxis and what insights may be useful for OT decolonial praxis. We identify and describe two content areas: (a) SET biases and (b) recommendations for alternatives promoting OT decolonial praxis. A total of 92 articles were sourced from five databases. Of …


A Scoping Review Of Occupation-Based Interventions For Women With Breast Cancer, Whitney Lucas Molitor, Erika Clark, Brittney Moser Jan 2023

A Scoping Review Of Occupation-Based Interventions For Women With Breast Cancer, Whitney Lucas Molitor, Erika Clark, Brittney Moser

The Open Journal of Occupational Therapy

Background: Globally, breast cancer is the most commonly diagnosed cancer. Women diagnosed with breast cancer often experience physical and psychosocial changes influencing occupational participation and quality of life. Limited evidence exists that reports outcomes of occupation-based occupational therapy interventions for women with breast cancer.

Method: In this scoping review, we map occupation-based occupational therapy interventions conducted by occupational therapy professionals for women undergoing rehabilitation for breast cancer. The Joanna Briggs Institute Guidelines provided a structure for the review.

Results: Six articles met the inclusion criteria. Interventions included health management, leisure, and social participation occupations.

Conclusion: Occupational …


Rest And Sleep Patterns And Activities Of Residents In Long-Term Care Facilities: A Descriptive Study, Pei-Fen Chang, Kai-Lai Tsai, Clarissa Richard, Harriett A. Davidson, Gayle Hersch Jan 2023

Rest And Sleep Patterns And Activities Of Residents In Long-Term Care Facilities: A Descriptive Study, Pei-Fen Chang, Kai-Lai Tsai, Clarissa Richard, Harriett A. Davidson, Gayle Hersch

The Open Journal of Occupational Therapy

Background:To facilitate healthy occupational participation and highlight the significance of rest and sleep for older adults, this study aimed to provide a description of rest and sleep patterns and activities of residents in long-term care facilities (LTCFs).

Method: Secondary analysis of rest and sleep data collected from a funded R21 study was conducted. Twenty-nine residents were interviewed using the Yesterday Interview (YI) to describe their time and daily activities, including rest and sleep patterns and activities.

Results: Average time spent sleeping was 10.22 (±1.77) hr and resting was 4.77 (±3.3) hr. Data were also collected on …


Patient-Reported Outcome Measures Of Function And Quality Of Life In Individuals With Lower Extremity Lymphedema: A Scoping Review, Rachel A. Dratnol, Laura H. Vanpuymbrouck Jan 2023

Patient-Reported Outcome Measures Of Function And Quality Of Life In Individuals With Lower Extremity Lymphedema: A Scoping Review, Rachel A. Dratnol, Laura H. Vanpuymbrouck

The Open Journal of Occupational Therapy

Background: Lower extremity lymphedema (LEL) is more prevalent than lymphedema in other body parts. Assessing lymphedema severity and impact on occupational functioning and quality of life (QOL) is essential to client-centered care in occupational therapy. The purpose of this study was to identify and compare the patient-reported outcome measures (PROMs) available to assess QOL and/or level of functioning in individuals with LEL and studies using such assessments.

Method: A search of two online databases (PubMed and CINAHL) yielded 15 studies. A scoping review was completed.

Results: Numerous PROMs were identified in the development and/or validation studies or …


A Survey Of Universal Design At Museums: Current Industry Practice And Perceptions, Jennifer K. Fortuna, Kayleigh Thomas, Jenna Asper, Laura Matney, Kyra Chase, Stephanie Ogren, Julia Vandermolen Jan 2023

A Survey Of Universal Design At Museums: Current Industry Practice And Perceptions, Jennifer K. Fortuna, Kayleigh Thomas, Jenna Asper, Laura Matney, Kyra Chase, Stephanie Ogren, Julia Vandermolen

The Open Journal of Occupational Therapy

Background: Museums are key educational and cultural resources in the community, yet many are not accessible to visitors with disabilities. Universal design promotes products and environments usable to the greatest extent possible by all people, regardless of ability. This study explores current industry practice and perceptions of accessibility and universal design in a small sample of American museums. Suggestions for how occupational therapists can help museums go above and beyond ADA guidelines are provided.

Method: An 17-item cross-sectional survey was used to collect data. Twenty-five museum associations assisted with recruitment. A descriptive numerical summary and qualitative analysis were …


The Impact Of A Two-Visit Occupational Therapy Home Modification Model On Low-Income Older Adults, Anna Y. Grasso, Annmarie Murphy, Cynthia Abbott-Gaffney Jan 2023

The Impact Of A Two-Visit Occupational Therapy Home Modification Model On Low-Income Older Adults, Anna Y. Grasso, Annmarie Murphy, Cynthia Abbott-Gaffney

The Open Journal of Occupational Therapy

Background: Various studies support the benefit of occupational therapist-led home modification to support successful aging in place for older adults. However, methodological differences limit generalizability. This study aimed to determine the impact of a replicable two-visit occupational therapy home modification program on occupational performance of low-income, community-dwelling older adults.

Method: The researcher used a quasi-experimental one group pretest-posttest design. The participants were low-income homeowners, age 55 years and older, with decreased performance and/or satisfaction in one or more ADLs and IADLs as determined by the COPM. An occupational therapist provided the participants with a home safety assessment using …


Predictors Of Hospital Readmissions For People With Chronic Conditions, Melanie Morriss Tkach, Patricia Bowyer, Marsha Neville, Timothy J. Wolf, Gerald Goodman Jan 2023

Predictors Of Hospital Readmissions For People With Chronic Conditions, Melanie Morriss Tkach, Patricia Bowyer, Marsha Neville, Timothy J. Wolf, Gerald Goodman

The Open Journal of Occupational Therapy

Background: Hospital readmissions remain prominent in health care. Functional, cognitive, and environmental factors predict hospital readmissions but may not be thoroughly measured or addressed prior to discharge.

Method: In this cross-sectional study, people hospitalized with chronic conditions completed measures of self-care function, functional cognition, occupational competence, and environmental impact. They also participated in a phone call or medical records review to identify hospital readmissions within 30 days of discharge. In a group session, occupational therapists who work in acute care completed acceptability, appropriateness, and feasibility measures for the standardized assessments administered to hospital participants.

Results: Occupational competence …


Mixed-Method Study Of The Experiences And Routines Of Caregivers Of Children With Type 1 Diabetes, Evelina Wozniak, Lisa Cover, Yongyue Qi, Vanessa D. Jewell Jan 2023

Mixed-Method Study Of The Experiences And Routines Of Caregivers Of Children With Type 1 Diabetes, Evelina Wozniak, Lisa Cover, Yongyue Qi, Vanessa D. Jewell

The Open Journal of Occupational Therapy

Background: Type 1 diabetes is one of the most prevalent chronic childhood conditions that affects family roles, routines, and the ability to participate in meaningful occupations after a child’s diagnosis. Because of the complex health management routines required to ensure the safety and well-being of a child with type 1 diabetes, caregivers may experience decreased overall health and well-being.

Method: This sequential mixed-method study used a cross-sectional survey (n = 37) and phenomenological interviews (n = 6) to explore burden (the Burden Scale for Family Caregivers), quality of life (the WHO Quality of Life-BREF), and role engagement (a …


The Parents' Perspective: Experiences In Parent-Mediated Pediatric Occupational Therapy For Children With Neurodevelopmental Disorders, Allison Klowan, Mary Beth Kadlec, Stefanie Johnston Jan 2023

The Parents' Perspective: Experiences In Parent-Mediated Pediatric Occupational Therapy For Children With Neurodevelopmental Disorders, Allison Klowan, Mary Beth Kadlec, Stefanie Johnston

The Open Journal of Occupational Therapy

Background: Parent-mediated occupational therapy (OT) is a family-centered method of providing care for children and their families. This study aimed to understand and describe the parents’ perspectives of whether parent-mediated OT services improve child participation and parent-child social interactions in the home and community.

Method: This study was performed with a qualitative, phenomenological research design using focus groups. Eight participants were included in the study who were parents of children with at least one NDD, such as autism spectrum disorder or attention-deficit/hyperactivity disorder.

Results: Four major themes were developed: It’s a Family Affair, Sometimes it Just Takes …


Predictors Of Daily Activity Performance Of Children With Autism And Its Association To Autism Characteristics, Neta Katz Zetler, Eynat Gal, Batya Engel Yeger Jan 2023

Predictors Of Daily Activity Performance Of Children With Autism And Its Association To Autism Characteristics, Neta Katz Zetler, Eynat Gal, Batya Engel Yeger

The Open Journal of Occupational Therapy

Background: The daily activity performance of children with autism spectrum disorder (ASD) is a central focus of occupational therapists. Yet, the existing performance-based assessments of basic and instrumental daily activities in children are limited and their application on children with ASD is scarce. The purpose of this study is to examine if daily activity performance of children with ASD is impaired as compared to children with typical development (TD), and to examine possible predictors of daily activity performance in children with ASD.

Method: The participants included 39 children with ASD and 40 children with TD, 6–10 years of …


Holistic, Person-Centered Evaluation To Understand The Experiences And Needs Of Displaced Refugee Youths: A Descriptive Mixed Methods Narrative Study, Rebecca S. Lord, Jaime P. Muñoz Jan 2023

Holistic, Person-Centered Evaluation To Understand The Experiences And Needs Of Displaced Refugee Youths: A Descriptive Mixed Methods Narrative Study, Rebecca S. Lord, Jaime P. Muñoz

The Open Journal of Occupational Therapy

Background: Refugee youth face acculturation stress, language barriers, xenophobia, and difficulty accessing resources. These factors, combined with migration trauma, negatively impact youths’ psychosocial health. This study aimed to conceptualize evaluation in an occupation-focused, person-centered framework with the goal of informing therapists working with displaced children.

Methods: This mixed methods, descriptive study used narrative research methodologies to understand the experiences of refugee youths. A variety of assessment tools were used to elicit these youths’ stories and create in-depth occupational profiles. The evaluation protocol that was created generated extensive data used to inform programming at a community non-profit to ensure …


State Of The Journal: Introducing Assistant Editors, Diane Powers Dirette Jan 2023

State Of The Journal: Introducing Assistant Editors, Diane Powers Dirette

The Open Journal of Occupational Therapy

No abstract provided.


A Swimming Program For Children With Autism Spectrum Disorders: Assessing Critical Parameters From Caregivers’ Perspectives, Abir K. Bekhet, Norah Johnson, Tana Karenke, Amy Van Hecke Jan 2023

A Swimming Program For Children With Autism Spectrum Disorders: Assessing Critical Parameters From Caregivers’ Perspectives, Abir K. Bekhet, Norah Johnson, Tana Karenke, Amy Van Hecke

International Journal of Aquatic Research and Education

One in 54 individuals is diagnosed with autism spectrum disorders (ASD). Swimming can impact the physical and mental well-being of persons with ASD, which in turn may improve their caregivers’ well-being. The purpose of this qualitative evaluation study is to assess the necessity, acceptability, feasibility, fidelity, and beginning effectiveness of a 12-session swimming training program (STP) at an indoor university pool designed to teach persons with ASD how to swim, and to teach caregivers precautions for safety around water. Participants included 7 boys, and 3 girls with ASD [mean age 7.05 years (SD 1.17)] and their caregivers. Results indicated that …


Potential Of Biduri Fiber (Calotropis Gigantea) As Material For Oil Spill Absorbent, Anne Sukmawati, Wulan Septiani Jan 2023

Potential Of Biduri Fiber (Calotropis Gigantea) As Material For Oil Spill Absorbent, Anne Sukmawati, Wulan Septiani

Journal of Materials Exploration and Findings

Biduri fiber (Calotropis gigantea) is a natural hollow fiber with hydrophobic and oleophilic properties potentially used as oil spilled sorbent from seawater. This study aims to determine the absorption capacity and efficiency of the Biduri fiber and membrane to fuel oil. Measurement of oil absorption to seawater was carried out at various fiber weights (0.5-1.5 g), fiber composition (50-95%), contact time (10-90 minutes), temperature (30 and 50°C), and compared with commercial products. The results showed that the fiber weight variation of 0.5-1.5 g has an average absorption efficiency of 96.67%, and the highest absorption was obtained in a weight of …


Role Of Oxides Of Nitrogen In The Ozone-Cardiorespiratory Visit Association, Xerxes Seposo, Kayo Ueda, Chris Fook Sheng Ng, Lina Madaniyazi, Seiji Sugata, Ayako Yoshino, Akinori Takami Jan 2023

Role Of Oxides Of Nitrogen In The Ozone-Cardiorespiratory Visit Association, Xerxes Seposo, Kayo Ueda, Chris Fook Sheng Ng, Lina Madaniyazi, Seiji Sugata, Ayako Yoshino, Akinori Takami

Ateneo School of Medicine and Public Health Publications

Ozone (O3)-induced health effects vary in terms of severity, from deterioration of lung function and hospitalization to death. Several studies have reported a linear increase in health risks after O3 exposure. However, current evidence suggests a non-linear U- and J-shaped concentration-response (C-R) function. The potential increasing risks with decreasing O3 concentrations may seem counterintuitive from the traditional standpoint that decreasing exposure should lead to decreasing health risks. Tus, the question of whether the increasing risks with decreasing concentrations are truly O3-induced or might be from other C-R mechanisms. If these potential risks were not accounted for, this may have contributed …


Retrospective Dataset And Survey Analyses Identify Gaps In Data Collection For Craniopharyngioma And Priorities Of Patients And Families Affected By The Disease, Emily Marshall, Nikhil Joshi, Julia Crowley, Shana Mccormack, Sylvia Cheng, Walter Faig, Phillip B Storm, Adam Resnick, Sabine Mueller, Fatema Malbari, Cassie Kline Jan 2023

Retrospective Dataset And Survey Analyses Identify Gaps In Data Collection For Craniopharyngioma And Priorities Of Patients And Families Affected By The Disease, Emily Marshall, Nikhil Joshi, Julia Crowley, Shana Mccormack, Sylvia Cheng, Walter Faig, Phillip B Storm, Adam Resnick, Sabine Mueller, Fatema Malbari, Cassie Kline

Department of Medicine Faculty Papers

Introduction: Craniopharyngioma is a rare, low-grade tumor located in the suprasellar region of the brain, near critical structures like the pituitary gland. Here, we concurrently investigate the status of clinical and genomic data in a retrospective craniopharyngioma cohort and survey-based data to better understand patient-relevant outcomes associated with existing therapies and provide a foundation to inform new treatment strategies.

Methods: Clinical, genomic, and outcome data for a retrospective cohort of patients with craniopharyngioma were collected and reviewed through the Children's Brain Tumor Network (CBTN) database. An anonymous survey was distributed to patients and families with a diagnosis of craniopharyngioma to …


Telehealth In Medicine: Predictions 2023–2024, Jiang Li, Ingrid Vasiliu-Feltes, Kathleen Mcgrow, Brendan F. Smith, Paul Barach, Sweta Sneha, Francis X. Campion Jan 2023

Telehealth In Medicine: Predictions 2023–2024, Jiang Li, Ingrid Vasiliu-Feltes, Kathleen Mcgrow, Brendan F. Smith, Paul Barach, Sweta Sneha, Francis X. Campion

College of Population Health Faculty Papers

Each year, Telehealth and Medicine Today asks experts in the field to share their insights into the future and predict how telehealth will influence uptake and healthcare in the new year.


Enhancing The Quality Of Life For Senior Citizens: A Facilitator’S Guidebook For Mindful Music And Movement, Shannon Sexton Jan 2023

Enhancing The Quality Of Life For Senior Citizens: A Facilitator’S Guidebook For Mindful Music And Movement, Shannon Sexton

Mindfulness Studies Theses

Music appreciation and enjoyment enhance well-being throughout the lifespan. The challenges and constraints that people experience as they age can lead to lack of access to music, decreased physical activity, and fewer avenues for creative expression. Group music and movement interventions created for older populations offer opportunities for social connection and improved quality of life. Mindful practices add further benefit when combined with these interventions. Current available programs are scarce and most often do not encompass mixed modalities. In addition, the benefits of these programs do not show long-term sustainability. The purpose of this thesis is to explore the effects …


Israeli Professionals Understanding Of Selective Mutism, Tal Hanan Jan 2023

Israeli Professionals Understanding Of Selective Mutism, Tal Hanan

Expressive Therapies Dissertations

This study employed art-based research with phenomenological qualitative inquiry to understand the perspectives of professionals who are working in the Israeli school system with children diagnosed with selective mutism. Selective mutism (SM) is a disorder originated in anxiety in which a child, between the ages of 3–5, does not speak at school but does speak at home (APA, 2022). In this research, the researcher facilitated a professional workshop based on Dillon (2016) and a similar workshop conducted by Harwood and Bork (2011). The aim was to broaden the knowledge and investigate the opinions of professionals working with children diagnosed with …


Adar1 Deletion Causes Degeneration Of The Exocrine Pancreas Via Mavs-Dependent Interferon Signaling, Dhwani N Rupani, Fredrik I Thege, Vidhi Chandra, Hajar Rajaei, Robert W Cowan, Sonja M Wörmann, Olivereen Le Roux, Prerna Malaney, Sara L Manning, Jack Hashem, Jennifer Bailey-Lundberg, Andrew D Rhim, Florencia Mcallister Jan 2023

Adar1 Deletion Causes Degeneration Of The Exocrine Pancreas Via Mavs-Dependent Interferon Signaling, Dhwani N Rupani, Fredrik I Thege, Vidhi Chandra, Hajar Rajaei, Robert W Cowan, Sonja M Wörmann, Olivereen Le Roux, Prerna Malaney, Sara L Manning, Jack Hashem, Jennifer Bailey-Lundberg, Andrew D Rhim, Florencia Mcallister

Faculty, Staff and Student Publications

Adenosine deaminase acting on RNA 1 (ADAR1) is an RNA-binding protein that deaminates adenosine (A) to inosine (I). A-to-I editing alters post-transcriptional RNA processing, making ADAR1 a crucial regulator of gene expression. Consequently, Adar1 has been implicated in organogenesis. To determine the role of Adar1 in pancreatic development and homeostasis, we conditionally deleted Adar1 from the murine pancreas (Ptf1aCre/+; Adar1Fl/Fl). The resulting mice had stunted growth, likely due to malabsorption associated with exocrine pancreatic insufficiency. Analyses of pancreata revealed ductal cell expansion, heightened interferon-stimulated gene expression and an increased influx of immune cells. Concurrent deletion of Adar1 and Mavs, a …


A Pleiotropic Variant In Dnajb4 Is Associated With Multiple Myeloma Risk, Marco Dicanio, Matteo Giaccherini, Alyssa Clay-Gilmour, Angelica Macauda, Juan Sainz, Mitchell J Machiela, Malwina Rybicka-Ramos, Aaron D Norman, Agata Tyczyńska, Stephen J Chanock, Torben Barington, Shaji K Kumar, Parveen Bhatti, Wendy Cozen, Elizabeth E Brown, Anna Suska, Eva K Haastrup, Robert Z Orlowski, Marek Dudziński, Ramon Garcia-Sanz, Marcin Kruszewski, Joaquin Martinez-Lopez, Katia Beider, Elżbieta Iskierka-Jazdzewska, Matteo Pelosini, Sonja I Berndt, Małgorzata Raźny, Krzysztof Jamroziak, S Vincent Rajkumar, Artur Jurczyszyn, Annette Juul Vangsted, Pilar Garrido Collado, Ulla Vogel, Jonathan N Hofmann, Mario Petrini, Aleksandra Butrym, Susan L Slager, Elad Ziv, Edyta Subocz, Graham G Giles, Niels Frost Andersen, Grzegorz Mazur, Marzena Watek, Fabienne Lesueur, Michelle A T Hildebrandt, Daria Zawirska, Lene Hyldahl Ebbesen, Herlander Marques, Federica Gemignani, Charles Dumontet, Judit Várkonyi, Gabriele Buda, Arnon Nagler, Agnieszka Druzd-Sitek, Xifeng Wu, Katalin Kadar, Nicola J Camp, Norbert Grzasko, Rosalie G Waller, Celine Vachon, Federico Canzian, Daniele Campa Jan 2023

A Pleiotropic Variant In Dnajb4 Is Associated With Multiple Myeloma Risk, Marco Dicanio, Matteo Giaccherini, Alyssa Clay-Gilmour, Angelica Macauda, Juan Sainz, Mitchell J Machiela, Malwina Rybicka-Ramos, Aaron D Norman, Agata Tyczyńska, Stephen J Chanock, Torben Barington, Shaji K Kumar, Parveen Bhatti, Wendy Cozen, Elizabeth E Brown, Anna Suska, Eva K Haastrup, Robert Z Orlowski, Marek Dudziński, Ramon Garcia-Sanz, Marcin Kruszewski, Joaquin Martinez-Lopez, Katia Beider, Elżbieta Iskierka-Jazdzewska, Matteo Pelosini, Sonja I Berndt, Małgorzata Raźny, Krzysztof Jamroziak, S Vincent Rajkumar, Artur Jurczyszyn, Annette Juul Vangsted, Pilar Garrido Collado, Ulla Vogel, Jonathan N Hofmann, Mario Petrini, Aleksandra Butrym, Susan L Slager, Elad Ziv, Edyta Subocz, Graham G Giles, Niels Frost Andersen, Grzegorz Mazur, Marzena Watek, Fabienne Lesueur, Michelle A T Hildebrandt, Daria Zawirska, Lene Hyldahl Ebbesen, Herlander Marques, Federica Gemignani, Charles Dumontet, Judit Várkonyi, Gabriele Buda, Arnon Nagler, Agnieszka Druzd-Sitek, Xifeng Wu, Katalin Kadar, Nicola J Camp, Norbert Grzasko, Rosalie G Waller, Celine Vachon, Federico Canzian, Daniele Campa

Faculty, Staff and Student Publications

Pleiotropy, which consists of a single gene or allelic variant affecting multiple unrelated traits, is common across cancers, with evidence for genome-wide significant loci shared across cancer and noncancer traits. This feature is particularly relevant in multiple myeloma (MM) because several susceptibility loci that have been identified to date are pleiotropic. Therefore, the aim of this study was to identify novel pleiotropic variants involved in MM risk using 28 684 independent single nucleotide polymorphisms (SNPs) from GWAS Catalog that reached a significant association (P < 5 × 10-8 ) with their respective trait. The selected SNPs were analyzed in 2434 MM cases and 3446 controls from the International Lymphoma Epidemiology Consortium (InterLymph). The 10 SNPs showing the strongest associations with MM risk in InterLymph were selected for replication in an independent set of 1955 MM cases and 1549 controls from the International Multiple Myeloma rESEarch (IMMEnSE) consortium and 418 MM cases and 147 282 controls from the FinnGen project. The combined analysis of the three studies identified an association between DNAJB4-rs34517439-A and an increased risk of developing MM (OR = 1.22, 95%CI 1.13-1.32, P = 4.81 × 10-7 ). rs34517439-A is associated with a modified expression of the FUBP1 gene, which encodes a multifunctional DNA and RNA-binding protein that it was observed to influence the regulation of various genes involved in cell cycle regulation, among which various oncogenes and oncosuppressors. In conclusion, with a pleiotropic scan approach we identified DNAJB4-rs34517439 as a potentially novel MM risk locus.


Evaluating The Effects Of Botulinum Toxins To Minimize Post Cleft Lip Hypertrophic Scar, Haider A Jassim Jan 2023

Evaluating The Effects Of Botulinum Toxins To Minimize Post Cleft Lip Hypertrophic Scar, Haider A Jassim

Iraqi National Journal of Medicine

Abstract:_x000D_  _x000D_ Background: Cleft lip deformity is one of the most common congenital anomalies. Repair of cleft lip may create too much tension especially when done in wide cleft lip, and this may result in unacceptable scar._x000D_  _x000D_ Aim of study: To evaluate the efficacy of botulinum toxin in reducing or preventing post cheiloplasty hypertrophic scar._x000D_  _x000D_ Patient and method: Between the period from October 2019 to August 2021, 10 patients with cleft lip were subjected to primary cheiloplasty using Millard rotation advancement flap technique followed by botulinum toxin injection into the site of repair. Follow up period was 6 …


Unusual Presentation Of Malignant Phyllodes Tumor In A Young Female: (Case Report And Review Of Literatures): Malignant Phyliodes Tumor In Adolesent., Hind Al-Hashemi, Saad Abdulbaqi Alomar, Sawsan Al-Haroon Jan 2023

Unusual Presentation Of Malignant Phyllodes Tumor In A Young Female: (Case Report And Review Of Literatures): Malignant Phyliodes Tumor In Adolesent., Hind Al-Hashemi, Saad Abdulbaqi Alomar, Sawsan Al-Haroon

Iraqi National Journal of Medicine

SUMMARY:_x000D_ Phyllodes tumor (PT) of the breast is rare in adolescent females, particularly malignant ones. It usually occurs in middle aged and older women. Malignant phyllodes (MP) do have a recurrence and a metastatic potential, unlike benign or borderline PT. We present the case of a 16-years old female presenting with a 6- month history of a progressive enlarged left breast mass. Tumor was excised as a mass of 7 cm in maximum diameter and sent for histopathological examination. The Histopathology revealed features of malignant phyllodes tumor that were confirmed by immunohistochemistry.


Presentation And Management Of Choledochal Cysts In Children: The Experience Of A Single Institute From A Developing Country: Choledochal Cysts In Children, Moaied A. Hassan, Thura K. Ja'afar, Sadik H. Kadhem Jan 2023

Presentation And Management Of Choledochal Cysts In Children: The Experience Of A Single Institute From A Developing Country: Choledochal Cysts In Children, Moaied A. Hassan, Thura K. Ja'afar, Sadik H. Kadhem

Iraqi National Journal of Medicine

BACKGROUND: Choledochal cysts are rare congenital biliary tract malformations. Presentation is variable based on age at presentation and type of the cyst. Total cyst excision with biliary reconstruction is the treatment of choice._x000D_ AIM OF THE STUDY: to present our experience with the presentation and management of these rare malformations with literature review._x000D_ MATERIALS AND METHODS: A retrospective analysis of a series of seven patients managed during the period from June 2015 to July 2020 in our institution. Recorded clinical data included sex, age at presentation, mode of presentation, diagnostic modality, cyst type and histopathology, preoperative course, operative procedure, and …


A Pleuropulmonary Blastoma: A Rare Malignant Lung Disease In Children: Pleuropulmonary Blastoma, Nayef Farhan Jan 2023

A Pleuropulmonary Blastoma: A Rare Malignant Lung Disease In Children: Pleuropulmonary Blastoma, Nayef Farhan

Iraqi National Journal of Medicine

Pleuropulmonary blastoma (PPB) is Avery uncommon, mesenchymal malignant tumor in chest cavity that occurs mostly in children before preschool age (less than 6year old) . while it is the most popular primary pleural and lung tumor in children and adolescent malignancy. PPB  has three macroscopically subtypes on a tumor have poor progression pathway start from cystic PPB (type I) to mixed cystic and solid (type II) and pure solid (type III). In the majority of PPB cases A gremlin mutation `need multimodal aggressive therapies including surgery and chemotherapy and/or radiotherapy. the study perform in Basra oncology center during eight years …


Incidence Of Registered Tuberculosis In Nineveh Governorate, A Case Study: Incidence Of Registered Tuberculosis In Nineveh Governorate, A Case Study, Rafia Alnuaim, Nabaa Al-Jawadi, Liqaa Almoosa Jan 2023

Incidence Of Registered Tuberculosis In Nineveh Governorate, A Case Study: Incidence Of Registered Tuberculosis In Nineveh Governorate, A Case Study, Rafia Alnuaim, Nabaa Al-Jawadi, Liqaa Almoosa

Iraqi National Journal of Medicine

Background After data has been sorted, statistical analysis is used to compare it. Statistical analysis was used to compare tuberculosis data from two different and distinct years in order to determine the extent of the development of this disease._x000D_ Aim This study aimed to estimate the annual incidence of registered tuberculosis cases in the Nineveh Governorate before and after the (COVID-19) pandemic outbreak. These injuries were compared with data on this disease recorded in Iraq, neighboring countries, and the world. To investigate the personal characteristics and fate of diagnosed patients was yet another aim._x000D_ Methods Data on diagnosed tuberculosis patients …


Progressive Interstitial Lung Disease In Relatives Of Patients With Pulmonary Fibrosis, Jonathan A Rose, Maria A Planchart Ferretto, Anthony H Maeda, Maria F Perez Garcia, Nikkola E Carmichael, Swati Gulati, Mary B Rice, Hilary J Goldberg, Rachel K Putman, Hiroto Hatabu, Benjamin A Raby, Ivan O Rosas, Gary M Hunninghake Jan 2023

Progressive Interstitial Lung Disease In Relatives Of Patients With Pulmonary Fibrosis, Jonathan A Rose, Maria A Planchart Ferretto, Anthony H Maeda, Maria F Perez Garcia, Nikkola E Carmichael, Swati Gulati, Mary B Rice, Hilary J Goldberg, Rachel K Putman, Hiroto Hatabu, Benjamin A Raby, Ivan O Rosas, Gary M Hunninghake

Faculty, Staff and Students Publications

No abstract provided.


Quantification Of Patient-Specific Coronary Material Properties And Their Correlations With Plaque Morphological Characteristics: An In Vivo Ivus Study, Liang Wang, Akiko Maehara, Xiaoguo Zhang, Rui Lv, Yangyang Qu, Xiaoya Guo, Jian Zhu, Zheyang Wu, Kristen L Billiar, Jie Zheng, Lijuan Chen, Genshan Ma, Gary S Mintz, Dalin Tang Jan 2023

Quantification Of Patient-Specific Coronary Material Properties And Their Correlations With Plaque Morphological Characteristics: An In Vivo Ivus Study, Liang Wang, Akiko Maehara, Xiaoguo Zhang, Rui Lv, Yangyang Qu, Xiaoya Guo, Jian Zhu, Zheyang Wu, Kristen L Billiar, Jie Zheng, Lijuan Chen, Genshan Ma, Gary S Mintz, Dalin Tang

2020-Current year OA Pubs

BACKGROUND: A method using in vivo Cine IVUS and VH-IVUS data has been proposed to quantify material properties of coronary plaques. However, correlations between plaque morphological characteristics and mechanical properties have not been studied in vivo.

METHOD: In vivo Cine IVUS and VH-IVUS data were acquired at 32 plaque cross-sections from 19 patients. Six morphological factors were extracted for each plaque. These samples were categorized into healthy vessel, fibrous plaque, lipid-rich plaque and calcified plaque for comparisons. Three-dimensional thin-slice models were constructed using VH-IVUS data to quantify in vivo plaque material properties following a finite element updating approach by matching …