Medicine and Health Sciences Commons^™

Examining The Effect Of Physician Language On Physician Impressions, Kathleen L. Hopps, Anna H. Rini, Maggie E. Williams, Gina A. Paganini, E. Paige Lloyd

DU Undergraduate Research Journal Archive

Previous research provides evidence that stigma can be perpetuated through language with consequences for well-being and quality of care. For example, providers who use stigmatizing language transmit bias toward patients with implications for care provided by other healthcare professionals. The current work extends upon this research by investigating perceptions of physicians who use stigmatizing or humanizing language. The current work sought to document the negative consequences of providers’ indelicate language on impressions of the provider, thereby motivating thoughtful language choices. To this end, the current work experimentally manipulated the language (stigmatizing, identity-first and destigmatizing, person-first) that hypothetical providers used to …

Keterpaparan Informasi Narkoba Dan Perilaku Pencarian Rehabilitasi: Studi Kasus Pada Penyalahguna Narkoba Di Rumah Kos, Yulia Pratiwi, Besral Besral

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Keterpaparan informasi narkoba merupakan faktor penting dalam pengetahuan dan perubahan perilaku, terutama untuk melakukan rehabilitasi. Rumah kos merupakan populasi yang dianggap rawan terhadap penyalahgunaan narkoba. Tujuan dari penelitian ini adalah untuk mengetahui hubungan keterpaparan informasi narkoba dengan perilaku pencarian rehabilitasi pada pengguna narkoba di rumah kos. Analisis regresi logistik ganda digunakan untuk menilai hubungan yang signifikan pada α=0,05. Hasil penelitian ini menunjukkan bahwa penyalahguna narkoba di rumah kos yang memiliki keterpaparan informasi yang baik memiliki kecenderungan untuk 3,8 kali lebih besar untuk berperilaku mencari rehabilitasi dibandingkan dengan mereka yang keterpaparan informasinya kurang (ORa=3,8; 95% CI=0,7 – 21,5), setelah dikontrol oleh …

Determinan Perilaku Pemeriksaan Payudara Sendiri (Sadari) Pada Mahasiswi Fakultas Kesehatan Masyarakat Universitas Indonesia Tahun 2022, Anna Triana, Ira Aulia, Yolanda Handayani

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Kanker payudara merupakan kanker dengan angka kejadian paling tinggi di dunia maupun di Indonesia. Keterlambatan diagnosa merupakan salah satu masalah dalam penanganan kanker payudara. Padahal keterlambatan diagnosa dapat dicegah dengan rutin melakukan pemeriksaan deteksi dini kanker payudara, salah satunya yaitu pemeriksaan payudara sendiri (SADARI). Penelitian ini merupakan penelitian analitik dengan metode kuantitatif dan menggunakan desain cross-sectional. Populasi dalam penelitian ini adalah seluruh mahasiswi kelas ekstensi angkatan tahun 2020, 2021, dan 2022 di Fakultas Kesehatan Masyarakat Universitas Indonesia. Pengambilan sampel dilakukan menggunakan teknik stratified sampling dengan hasil perhitungan akhir sampel sebanyak 108 responden. Pengambilan data dilakukan dengan instrumen kuesioner yang …

Hubungan Status Ekonomi Dengan Jumlah Anak Lahir Hidup Pada Wanita Kelompok Usia Kurang Dari 45 Tahun Dan Kelompok Usia 45-49 Tahun Kawin (Analisis Data Sdki 2017), Meilina Suwandi, Indang Trihandini

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Permasalahan kependudukan masih sangat kompleks. Salah satu hal nyata yang dihadapi adalah pertumbuhan penduduk yang relatif masih tinggi. Salah satu bagian dari pertumbuhan penduduk tidak terlepas dari jumlah anak lahir hidup. Salah satu faktor yang diduga berhubungan dengan jumlah anak lahir hidup adalah status ekonomi. Penelitian ini dilakukan untuk melihat besar hubungan antara status ekonomi dengan jumlah anak lahir hidup pada wanita usia kurang dari 45 tahun berstatus kawin yang masa reproduksinya masih berjalan dan usia 45-49 tahun berstatus kawin yang sudah masuk ke akhir masa reproduksi. Penelitian ini dilakukan menggunakan desain studi potong lintang menggunakan data Survei Demografi Kesehatan …

Autokorelasi Spasial Prevalensi Stunting Di Jawa Barat Tahun 2021, Aldila Riznawati, Deny Yudhistira, Martya Rahmaniati, Tiopan Sipahutar, Tris Eryando

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Angka prevalensi stunting Provinsi Jawa Barat tahun 2021 sebesar 24,5% dan menjadi salah satu provinsi dengan kategori stunting kronis-akut di Indonesia. Analisis spasial digunakan untuk mengetahui apakah terdapat korelasi secara spasial antar wilayah kabupaten/kota di Jawa Barat berdasarkan prevalensi stunting. Hasil penelitian menunjukkan adanya autokorelasi spasial positif dan terdapat korelasi secara spasial yang artinya prevalensi stunting di satu wilayah kabupaten/kota berkaitan dengan wilayah disekitarnya. Wilayah yang menjadi hotspot stunting di Jawa Barat tahun 2021 berdasarkan pola kluster yang terbentuk adalah Kabupaten Bandung, Kabupaten Bandung Barat, dan Kota Bandung. Ketiga wilayah ini menjadi prioritas utama dalam melakukan intervensi penurunan prevalensi stunting …

Hubungan Pemberdayaan Wanita Dengan Penggunaan Metode Kontrasepsi Jangka Panjang (Mkjp) Pada Wanita Usia Subur (15-49 Tahun) Yang Telah Menikah Di Indonesia: Analisis Data Sdki 2017, Triska Alya Muthi’Ah, Indang Trihandini

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Penggunaan kontrasepsi, khususnya MKJP, merupakan salah satu indikator terlaksananya program Keluarga Berencana. Namun berdasarkan hasil SDKI 2017, hanya terdapat 13,4% wanita yang menggunakan metode kontrasepsi jangka panjang. Berdasarkan beberapa penelitian sebelumnya, diketahui bahwa peran wanita penting terhadap penggunaan MKJP, dilihat melalui pemberdayaan wanita. Sehingga penelitian ini bertujuan untuk mengetahui hubungan pemberdayaan wanita dengan penggunaan metode kontrasepsi jangka panjang (MKJP) pada wanita usia subur (15-49 tahun) yang telah menikah di Indonesia. Penelitian ini merupakan penelitian kuantitatif dengan desain cross-sectional dan menggunakan data SDKI tahun 2017. Variabel dependen penelitian ini adalah penggunaan MKJP dengan variabel independen utama adalah pemberdayaan wanita. Analisis bivariat …

Artificial Intelligence-Based Chatbots For Promoting Health Behavioral Changes: Systematic Review, Abhishek Aggarwal, Cheuk Chi Tam, Dezhi Wu, Xiaoming Li, Shan Qiao

Publications

BACKGROUND: Artificial intelligence (AI)-based chatbots can offer personalized, engaging, and on-demand health promotion interventions. OBJECTIVE: The aim of this systematic review was to evaluate the feasibility, efficacy, and intervention characteristics of AI chatbots for promoting health behavior change. METHODS: A comprehensive search was conducted in 7 bibliographic databases (PubMed, IEEE Xplore, ACM Digital Library, PsycINFO, Web of Science, Embase, and JMIR publications) for empirical articles published from 1980 to 2022 that evaluated the feasibility or efficacy of AI chatbots for behavior change. The screening, extraction, and analysis of the identified articles were performed by following the PRISMA (Preferred Reporting Items …

From Tuberculosis Bedside To Bench: Ube2b Splicing As A Potential Biomarker And Its Regulatory Mechanism, Mengyuan Lyu, Jian Zhou, Yanbing Zhou, Weelic Chong, Wei Xu, Hongli Lai, Lu Niu, Yang Hai, Xiaojun Yao, Sheng Gong, Qinglan Wang, Yi Chen, Yili Wang, Liyu Chen, Ganzi People's Hospital, Jiongjiong Zeng, Chengdi Wang, Binwu Ying

Student Papers, Posters & Projects

Alternative splicing (AS) is an important approach for pathogens and hosts to remodel transcriptome. However, tuberculosis (TB)-related AS has not been sufficiently explored. Here we presented the first landscape of TB-related AS by long-read sequencing, and screened four AS events (S100A8-intron1-retention intron, RPS20-exon1-alternaitve promoter, KIF13B-exon4-skipping exon (SE) and UBE2B-exon7-SE) as potential biomarkers in an in-house cohort-1. The validations in an in-house cohort-2 (2274 samples) and public datasets (1557 samples) indicated that the latter three AS events are potential promising biomarkers for TB diagnosis, but not for TB progression and prognosis. The excellent performance of classifiers further underscored the diagnostic value …

New Synthetic Opioids: Clinical Considerations And Dangers, Amber Edinoff, David Martinez Garza, Stephen Vining, Megan Vasterling, Eric Jackson, Kevin Murnane, Adam Kaye, Richard Fair, Yair Jose Lopez Torres, Ahmed Badr, Elyse Cornett, Alan Kaye

School of Medicine Faculty Publications

Since the early 2010s, synthetic opioids have significantly contributed to overall opioid-related overdose mortalities. For point of reference, of the 68,630 opioid-related deaths recorded in 2020, 56,516 involved synthetic opioids. During much of this period, fentanyl has been the most commonly used synthetic opioid. This time when fentanyl was the most popular opioid has been called the “third wave” of the opioid crisis, partly because it led to a sharp rise in deaths from overdoses. Other synthetic opioids, such as carfentanil, protonitazene, and isotonitazene, have also become more widely diverted for nonmedical used. Carfentanil is an even more potent fentanyl …

Associating Outcomes After Hip Arthroscopy With Patient Resilience, Patrick F Szukics, Peters Otlans, Matthew Meade, Jeffrey Lynch, John P. Salvo

Rothman Institute Papers

Background: Higher patient resilience has been shown to be associated with improved patient-reported outcome measures (PROMs) at 6 months after hip arthroscopy.

Purpose: To examine the relationship between patient resilience and PROMs at minimum 2 years after hip arthroscopy.

Study design: Cross-sectional study; Level of evidence, 3.

Methods: Included were 89 patients (mean age, 36.9 years; mean follow-up, 4.6 years). Patient demographics, surgical details, and preoperative International Hip Outcome Tool-12 (iHOT-12) and visual analog scale (VAS) pain scores were collected retrospectively. Postoperative variables were collected via a survey and included the Brief Resilience Scale (BRS), Patient Activation Measure-13 (PAM-13), Pain …

Molecular Diagnostics In The Evaluation Of Thyroid Nodules: Current Use And Prospective Opportunities, Jena Patel, Joshua Klopper, Elizabeth E. Cottrill

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

Thyroid cancer is the most common endocrine malignancy with an estimated 43,800 new cases to be diagnosed in 2022 and representing the 7th most common cancer in women. While thyroid nodules are very common, being identified in over 60% of randomly selected adults, only 5-15% of thyroid nodules harbor thyroid malignancy. Therefore, it is incumbent upon physicians to detect and treat thyroid malignancies as is clinically appropriate and avoid unnecessary invasive procedures in patients with benign asymptomatic lesions. Over the last 15-20 years, rapid advances have been made in cytomolecular testing to aid in thyroid nodule management. Initially, indeterminate thyroid …

Monitoring Resistance And Biochemical Studies Of Three Egyptian Field Strains Of Spodoptera Littoralis (Lepidoptera: Noctuidae) To Six Insecticides, Moataz A M Moustafa, Rasha I A Moteleb, Yehia F Ghoneim, Sameh Sh Hafez, Reham E Ali, Essam E A Eweis, Nancy N Hassan

Faculty, Staff and Student Publications

BACKGROUND:

METHODS: Laboratory bioassays were carried out using the leaf-dipping method to examine the susceptibility of the laboratory and field strains to the tested insecticides. Activities of detoxification enzymes were determined in an attempt to identify resistance mechanisms.

RESULTS: The results showed that LC

CONCLUSION: Our findings, along with other tactics, are expected to help with the resistance management of

Maternal Gestational Diabetes Is Associated With High Risk Of Childhood Overweight And Obesity: A Cross-Sectional Study In Pre-School Children Aged 2–5 Years, Maria Mantzorou, Dimitrios Papandreou, Eleni Pavlidou, Sousana K. Papadopoulou, Maria Tolia, Maria Mentzelou, Antigoni Poutsidi, Georgios Antasouras, Georgios K. Vasios, Constantinos Giaginis

All Works

Background and Objectives: Childhood obesity is a global public health concern with long-term and serious health implications. An important factor for childhood obesity is maternal gestational diabetes mellitus (GDM), which in turn impacts maternal and offspring long-term health. This study aimed to investigate the associations between maternal GDM and childhood weight status and multiple anthropometric and sociodemographic factors and perinatal outcomes. Materials and Methods: A total of 5348 children aged 2–5 years old and their paired mothers took part in the study. Questionnaires were utilized to evaluate the sociodemographic factors and perinatal outcomes as well as smoking habits, educational level, …

Sperm Donor Attitudes And Experiences With Direct-To-Consumer Genetic Testing., Sascha Wodoslawsky, Joy Fatunbi, Rebecca Mercier, Andrea Mechanick Braverman

Department of Obstetrics and Gynecology Faculty Papers

OBJECTIVE: To identify factors influencing sperm donor willingness to participate in direct-to-consumer genetic testing, comfort with sharing genetically identifiable data in commercial genetic testing databases, and likelihood to donate sperm again.

DESIGN: Cross-sectional online anonymous survey.

SETTING: Multicenter, 2 large American sperm banks from July 1, 2020 to July10, 2021.

PATIENTS: Sperm donors from 1980 to 2020.

INTERVENTIONS: None.

MAIN OUTCOME MEASURES: Associations between donor demographic characteristics, donation history, and attitudes toward direct-to-consumer genetic testing.

RESULTS: A total of 396 donors completed the survey. Most donations (61.5%) occurred from 2010 to 2020, and 34.3% were nonidentified donations. Nonidentified donors were …

New Synthetic Opioids: Clinical Considerations And Dangers, Amber N. Edinoff, David Martinez Garza, Stephen P. Vining, Megan E. Vasterling, Eric D. Jackson, Kevin S. Murnane, Adam M. Kaye, Richard N. Fair, Yair Jose Lopez Torres, Ahmed E. Badr, Elyse M. Cornett, Alan D. Kaye

Pacific Faculty Work

Since the early 2010s, synthetic opioids have significantly contributed to overall opioid-related overdose mortalities. For point of reference, of the 68,630 opioid-related deaths recorded in 2020, 56,516 involved synthetic opioids. During much of this period, fentanyl has been the most commonly used synthetic opioid. This time when fentanyl was the most popular opioid has been called the “third wave” of the opioid crisis, partly because it led to a sharp rise in deaths from overdoses. Other synthetic opioids, such as carfentanil, protonitazene, and isotonitazene, have also become more widely diverted for nonmedical used. Carfentanil is an even more potent fentanyl …

Feasibility Of [18f]Fspg Pet For Early Response Assessment To Combined Blockade Of Egfr And Glutamine Metabolism In Wild-Type Kras Colorectal Cancer, Seong-Woo Bae, Jianbo Wang, Dimitra K Georgiou, Xiaoxia Wen, Allison S Cohen, Ling Geng, Mohammed Noor Tantawy, H Charles Manning

Faculty, Staff and Student Publications

Early response assessment is critical for personalizing cancer therapy. Emerging therapeutic regimens with encouraging results in the wild-type (WT) KRAS colorectal cancer (CRC) setting include inhibitors of epidermal growth factor receptor (EGFR) and glutaminolysis. Towards predicting clinical outcome, this preclinical study evaluated non-invasive positron emission tomography (PET) with (4S)-4-(3-[18F]fluoropropyl)-L-glutamic acid ([18F]FSPG) in treatment-sensitive and treatment-resistant WT KRAS CRC patient-derived xenografts (PDXs). Tumor-bearing mice were imaged with [18F]FSPG PET before and one week following the initiation of treatment with either EGFR-targeted monoclonal antibody (mAb) therapy, glutaminase inhibitor therapy, or the combination. Imaging was correlated with tumor volume and histology. In PDX …

Microrna Profiles In Intestinal Epithelial Cells In A Mouse Model Of Sepsis, Siqingaowa Caidengbate, Yuichi Akama, Anik Banerjee, Khwanchanok Mokmued, Eiji Kawamoto, Arong Gaowa, Louise D Mccullough, Motomu Shimaoka, Juneyoung Lee, Eun Jeong Park

Faculty, Staff and Student Publications

Sepsis is a systemic inflammatory disorder that leads to the dysfunction of multiple organs. In the intestine, the deregulation of the epithelial barrier contributes to the development of sepsis by triggering continuous exposure to harmful factors. However, sepsis-induced epigenetic changes in gene-regulation networks within intestinal epithelial cells (IECs) remain unexplored. In this study, we analyzed the expression profile of microRNAs (miRNAs) in IECs isolated from a mouse model of sepsis generated via cecal slurry injection. Among 239 miRNAs, 14 miRNAs were upregulated, and 9 miRNAs were downregulated in the IECs by sepsis. Upregulated miRNAs in IECs from septic mice, particularly …

Editorial: The Health Informatics Series: Evolving With A New Discipline, Marion Ball, Kathryn J. Hannah, Nhora Cortes-Comerer, Judith V. Douglas

Elsevier Open Access Agreement Publications-Archive

A brief history of the book series launched by Springer-Verlag in 1988 as Computers in Healthcare stands as a case study of its role in the development of informatics in medicine. Renamed Health Informatics in 1998, the series grew to include 121 titles as of September 2022, covering topics from dental informatics to ethics, from human factors to mobile health. An analysis of three titles now in their fifth editions reveals the evolution of content in the core disciplines of nursing informatics and health information management. Shifts in topics in the second editions of two landmark titles chart the history …

Microfluidic Concurrent Assessment Of Red Blood Cell Adhesion And Microcapillary Occlusion: Potential Hemorheological Biomarkers In Sickle Cell Disease, Yuncheng Man, Douglas H. Wu, Ran An, Karamoja Monchamp, Utku Goreke, Zoe Sekyonda, William J. Wulftange, Chiara Federici, Allison Bode, Lalitha V. Nayak, Umut A. Gurkan

Faculty Scholarship

Deformability and non-adherence are two fundamental functional properties of red blood cells (RBCs), which allow them to move unimpeded through the microvasculature. In sickle cell disease (SCD), polymerization of abnormal sickle hemoglobin leads to decreased deformability and increased membrane adhesiveness in RBCs. This contributes to abnormal blood vessel occlusion, which is central to the underlying pathophysiology. RBC deformability and adhesiveness are, therefore key hemorheological biomarkers in characterizing disease states as well as in evaluating novel therapeutics. To date, these important interrelated biomarkers have been assessed in distinct laboratory assays, without integration or concurrent assessment in vitro. To this end, we …

A Phase 2 Trial Of Ibrutinib And Nivolumab In Patients With Relapsed Or Refractory Classical Hodgkin's Lymphoma., Walter Hanel, Polina Shindiapina, David A Bond, Yazeed Sawalha, Narendranath Epperla, Timothy Voorhees, Rina Li Welkie, Ying Huang, Gregory K Behbehani, Xiaoli Zhang, Eric Mclaughlin, Wing K Chan, Jonathan E Brammer, Samantha Jaglowski, John C Reneau, Beth A Christian, Basem M William, Jonathon B Cohen, Robert A Baiocchi, Kami Maddocks, Kristie A Blum, Lapo Alinari

Oncology Articles

BACKGROUND: Relapsed or refractory classical Hodgkin lymphoma (cHL) remains a difficult treatment challenge. Although checkpoint inhibitors (CPI) have provided clinical benefit for these patients, responses are generally not durable, and progression eventually occurs. Discovering combination therapies which maximize the immune response of CPI therapy may overcome this limitation. We hypothesized that adding ibrutinib to nivolumab will lead to deeper and more durable responses in cHL by promoting a more favorable immune microenvironment leading to enhanced T-cell-mediated anti-lymphoma responses.

METHODS: We conducted a single arm, phase II clinical trial testing the efficacy of nivolumab in combination with ibrutinib in patients ≥18 …

Role Of Ribosome Recycling Factor In Natural Termination And Translational Coupling As A Ribosome Releasing Factor, Yoshio Inokuchi, Fabio Quaglia, Akikazu Hirashima, Yoshihiro Yamamoto, Hideko Kaji, Akira Kaji

Department of Biochemistry and Molecular Biology Faculty Papers

The role of ribosome recycling factor (RRF) of E. coli was studied in vivo and in vitro. We used the translational coupling without the Shine-Dalgarno sequence of downstream ORF (d-ORF) as a model system of the RRF action in natural termination of protein synthesis. For the in vivo studies we used the translational coupling by the adjacent coat and lysis genes of RNA phage GA sharing the termination and initiation (UAAUG) and temperature sensitive RRF. The d-ORF translation was measured by the expression of the reporter lacZ gene connected to the 5'-terminal part of the lysis gene. The results showed …

Detection And Characterization Of Constitutive Replication Origins Defined By Dna Polymerase Epsilon, Roman Jaksik, David A Wheeler, Marek Kimmel

Center for Medical Ethics and Health Policy Staff Publications

Background: Despite the process of DNA replication being mechanistically highly conserved, the location of origins of replication (ORI) may vary from one tissue to the next, or between rounds of replication in eukaryotes, suggesting flexibility in the choice of locations to initiate replication. Lists of human ORI therefore vary widely in number and location, and there are currently no methods available to compare them. Here, we propose a method of detection of ORI based on somatic mutation patterns generated by the mutator phenotype of damaged DNA polymerase epsilon (POLE).

Results: We report the genome-wide localization of constitutive ORI in POLE-mutated …

Multitrait Genome-Wide Analyses Identify New Susceptibility Loci And Candidate Drugs To Primary Sclerosing Cholangitis, Younghun Han, Jinyoung Byun, Catherine Zhu, Ryan Sun, Julia Y Roh, Heather J Cordell, Hyun-Sung Lee, Vikram R Shaw, Sung Wook Kang, Javad Razjouyan, Matthew A Cooley, Manal M Hassan, Katherine A Siminovitch, Trine Folseraas, David Ellinghaus, Annika Bergquist, Simon M Rushbrook, Andre Franke, Tom H Karlsen, Konstantinos N Lazaridis, Kathryn A. Mcglynn, Katherine A Mcglynn, Lewis R Roberts, Christopher I Amos, International Psc Study Group

Faculty, Staff and Students Publications

Primary sclerosing cholangitis (PSC) is a rare autoimmune bile duct disease that is strongly associated with immune-mediated disorders. In this study, we implemented multitrait joint analyses to genome-wide association summary statistics of PSC and numerous clinical and epidemiological traits to estimate the genetic contribution of each trait and genetic correlations between traits and to identify new lead PSC risk-associated loci. We identified seven new loci that have not been previously reported and one new independent lead variant in the previously reported locus. Functional annotation and fine-mapping nominated several potential susceptibility genes such as MANBA and IRF5. Network-based in silico drug …

Mitochondrial Phosphatidylethanolamine Modulates Ucp1 To Promote Brown Adipose Thermogenesis, Jordan M Johnson, Irfan J Lodhi, Et Al.

2020-Current year OA Pubs

Thermogenesis by uncoupling protein 1 (UCP1) is one of the primary mechanisms by which brown adipose tissue (BAT) increases energy expenditure. UCP1 resides in the inner mitochondrial membrane (IMM), where it dissipates membrane potential independent of adenosine triphosphate (ATP) synthase. Here, we provide evidence that phosphatidylethanolamine (PE) modulates UCP1-dependent proton conductance across the IMM to modulate thermogenesis. Mitochondrial lipidomic analyses revealed PE as a signature molecule whose abundance bidirectionally responds to changes in thermogenic burden. Reduction in mitochondrial PE by deletion of phosphatidylserine decarboxylase (PSD) made mice cold intolerant and insensitive to β3 adrenergic receptor agonist-induced increase in whole-body oxygen …

Is Vision Essential To Physical Therapist Practice? Perceptions Of Interested Parties In Dpt Education, Megan Flores, Kathryn Sawyer, Kathleen Manella, Kristy Demers, Germaine Ferreira, Derrick F. Campbell, Allan Besselink, Manuel A. Domenech

Education Collection

Introduction: The perceptions of students, faculty, staff, and clinicians regarding blindness or visual impairment (BVI) and physical therapist practice were explored before, during, and after interactions with a Doctor of Physical Therapy (DPT) student with BVI.

Review of Literature: Information is sparse about the prevalence of students with disabilities in DPT programs in the United States. Medical school programs that welcome students with disabilities report positive interactions with faculty and student peers.

Subjects: 36 (20 students, 11 faculty, 2 staff, and 3 clinical instructors)

Methods: A recent DPT graduate (pseudonym JM) with BVI classified as …

Trident - Spring 2023, Dugoni School Of Dentistry

Trident

The spring 2023 issue of the orthodontics alumni newsletter at University of the Pacific, Arthur A. Dugoni School of Dentistry

A Modern Multimodal Pain Protocol Eliminates The Need For Opioids For Most Patients Following Total Knee Arthroplasty: Results From A Retrospective Comparative Cohort Study, Leland Van Deventer, Amy Bronstone, Claudia Leonardi, Matthew Bennett, Peter Yager, Vinod Dasa

School of Medicine Faculty Publications

Purpose: Modern multimodal analgesia has been shown to significantly reduce opioid use following total knee arthroplasty (TKA). This study was conducted to determine if changing TKA discharge opioid prescriptions from automatic to upon request resulted in more opioid free recoveries without compromising pain control. Methods: Between December 2019 and August 2021, an orthopedic surgeon performed 144 primary unilateral TKAs; patients received the same multimodal analgesia protocol except for postoperative opioid prescribing. The first consecutively-treated cohort automatically received an opioid prescription following discharge (automatic group) and the second cohort received opioid prescriptions only upon request (upon request group). Opioid prescription data …

Association Between Serum Vitamin D And Metabolic Syndrome In A Sample Of Adults In Lebanon, Myriam Abboud, Rana Rizk, Suzan Haidar, Nadine Mahboub, Dimitrios Papandreou

All Works

The evidence on the association between vitamin D and metabolic syndrome (MetS) is inconclusive. This was a cross-sectional study to explore the relationship between vitamin D serum levels and MetS in a sample of Lebanese adults (n = 230), free of diseases that affect vitamin D metabolism, recruited from an urban large university and neighboring community. MetS was diagnosed according to the International Diabetes Federation criteria. A logistic regression analysis was performed taking MetS as the dependent variable, and vitamin D was forced into the model as an independent variable. The covariates included sociodemographic, dietary, and lifestyle variables. The mean …

College Of Health Professions News, Georgia Southern University

College of Health Professions: News & Publications (2012-2023)

• HSK Faculty Develop No-Cost HAP Library Guide

Bispecific T-Cell Engagers Therapies In Solid Tumors: Focusing On Prostate Cancer, Diana C Simão, Kevin K Zarrabi, José L Mendes, Ricardo Luz, Jorge A Garcia, William Kevin Kelly, Pedro C Barata

Department of Medical Oncology Faculty Papers

Over the past decade, immunotherapy has demonstrated an impressive improvement in treatment outcomes for multiple cancers. Following the landmark approvals for use of immune checkpoint inhibitors, new challenges emerged in various clinical settings. Not all tumor types harbor immunogenic characteristics capable of triggering responses. Similarly, many tumors' immune microenvironment allows them to become evasive, leading to resistance and, thus, limiting the durability of responses. To overcome this limitation, new T-cell redirecting strategies such as bispecific T-cell engager (BiTE) have become attractive and promising immunotherapies. Our review provides a comprehensive perspective of the current evidence of BiTE therapies in solid tumors. …