Medicine and Health Sciences Commons^™

Intolerance Of Uncertainty And Attitudes Towards Persons Living With Disabilities In Medical Students: Is There A Correlation?, Martinique Ogle, Dimitrios Papanagnou, Md, Kestrel Reopelle, Frances Rusnack, Jordan Feingold-Link, Maria Poluch, Nethra S. Ankam

Department of Emergency Medicine Faculty Papers

INTRODUCTION: Patients living with a disability experience an illness trajectory that may be uncertain. While navigating clinical uncertainty has been well-researched, health professionals' intolerance of uncertainty for patients living with disabilities has yet to be explored. We examined the relationship between medical students' intolerance of uncertainty with their attitudes towards people living with disabilities to better inform curricular efforts.

METHODS: We employed a survey-based design consisting of the Intolerance of Uncertainty Scale (IUS) and Disability Attitudes in Healthcare (DAHC) Scale to medical students upon completion of core clerkships (end of third-year of training). Data were de-identified. Mean DAHC and IUS …

Natural Disasters And Human Capital: Empirical Evidence From Indonesia, Lei Lv

USF Tampa Graduate Theses and Dissertations

In developing countries, natural disasters could destroy physical capital and adversely affect human capital accumulation by disrupting individual decisions. Such decisions play a critical role in determining individuals' human capital accumulation process and have a lifelong effect on their happiness and economic prosperity. To better understand how natural disasters affect human capital in developing countries, this dissertation uses the earthquakes in Indonesia as a natural experiment to study how this earthquake affects health, child marriage, and education. For the first chapter, I study how the 2006 Yogyakarta Earthquake a affects water-related acute disease symptomsin the short and long run. By …

Impact Of Intravenous Fluid Administration On Cardiac Output And Oxygenation During Cardiopulmonary Resuscitation, Jennifer Lutz, Yosef Levenbrown, Md Jobayer Hossain, Anne Hesek, Kelly E. Massa, James P. Keith, Thomas H. Shaffer

Department of Pediatrics Faculty Papers

Background: The efect of intravenous fuid (IVF) administration during cardiopulmonary resuscitation (CPR) is an unexplored factor that may improve cardiac output (CO) during CPR. The aim of this study was to determine the efect of IVF administration on CO and oxygenation during CPR.

Methods: This experimental animal study was performed in a critical care animal laboratory. Twenty-two Landrace-Yorkshire female piglets weighing 27–37 kg were anesthetized, intubated, and placed on positive pressure ventilation. Irreversible cardiac arrest was induced with bupivacaine. CPR was performed with a LUCAS 3 mechanical compression device. Pigs were randomized into IVF or no-IVF groups. Pigs in the …

Antioxidant And Cytotoxic Potential Of Potentized Preparation Of Cordyceps Sinensis In Vitro In Cancer Cell Lines, Vettrivel Arul, Rajamanickam Kandasamy, Mary Adharshna Sp

Indian Journal of Research in Homoeopathy

Background: The parasitic fungus Cordyceps sinensis (Ophiocordyceps sinensis) has been discovered in lepidopteran larvae, having known antitumor effects. Testing potentized Cordyceps sinensis in cancer cells could help broaden Homoeopathy cancer therapeutics.

Objectives: The objectives of the study were to evaluate the antioxidant and cytotoxicity activity of potentized preparation of Cordyceps sinensis in carcinoma cell-lines.

Methods: In this in vitro study, antioxidant activity was analyzed by the 2,2-diphenyl-1-picryl-hydrazyl-hydrate assay and the dilution with more antioxidant potential was further analyzed for cytotoxicity, using 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on various carcinoma cell lines: Breast cancer cell line (MCF-7), liver cancer cell line (HePG2), …

A Randomised, Double-Blind, Placebo-Controlled And Parallel-Arm Trial To Assess The Effect Of Homoeopathic Medicines On Chronic Rhinosinusitis, Praveen Oberai, Subhash Kaushik, Sunil Ramteke, M N. Sinha, Sarabjit Sarkar, Kalpana Gautam, Arvind Kumar, Harleen Kaur, Raj Kumar Manchanda, Roja Varanasi

Indian Journal of Research in Homoeopathy

Background: Chronic rhinosinusitis (CRS) is a significant health problem impacting health related quality of life.

Objectives: This study assesses the efficacy of individualised homoeopathy (IH) in LM potency in CRS.

Methods: A randomised, double-blind and placebo-controlled trial on patients with CRS was undertaken at four institutes, from July 2012 to December 2013. Eligible participants were randomised to IH in LM-potencies (n = 60) or a similar placebo (n = 60). Primary outcome was change in the total symptoms score (TSS) (area under the curve [AUC]) and in sinus nasal outcome test 22 over 3 months. Intention-to-treat approach was used …

Can The Sweet Pills Restore The Smiles Of Autistic Children?, Deepthi Gilla, K.C. Muraleedharan

Indian Journal of Research in Homoeopathy

The second of April marks World Autism Awareness Day (WAAD), every year globally. WAAD was designated by the United Nations in 2007 to help end stigmatization and discrimination against those with Autism and their caregivers. It aims to raise understanding and awareness of this global health issue at all levels of society. The alarming increase in prevalence (1 in 100-WHO) and potentially lifelong disabling nature of the disorder demands awareness as early identification and intervention are pivotal in the management of Autism.

Screening For Social Determinants Of Health In The Primary Care Setting: A Quality Improvement Project, Winifred Ann Shouse

Graduate Theses, Dissertations, and Capstones

Social determinants of health are the conditions in which individuals are born, age, work, and live that affect health status and outcomes (Rivich et al., 2019). These social and environmental factors can create barriers to patients being able to access and adhere to recommendations for chronic disease management (Gold, et al., 2019). Communication gaps between patients and primary care providers make it challenging for healthcare providers to be completely aware of the financial burdens their patients encounter (Patel et al., 2016). Research supports that identifying and addressing the barriers related to social determinants of health can improve the management of …

Calpain Activity Is Negatively Regulated By A Kctd7-Cullin-3 Complex Via Non-Degradative Ubiquitination, Jaiprakash Sharma, Shalaka Mulherkar, Uan-I Chen, Yan Xiong, Lakshya Bajaj, Byoung-Kyu Cho, Young Ah Goo, Hon-Chiu Eastwood Leung, Kimberley F Tolias, Marco Sardiello

2020-Current year OA Pubs

Calpains are a class of non-lysosomal cysteine proteases that exert their regulatory functions via limited proteolysis of their substrates. Similar to the lysosomal and proteasomal systems, calpain dysregulation is implicated in the pathogenesis of neurodegenerative disease and cancer. Despite intensive efforts placed on the identification of mechanisms that regulate calpains, however, calpain protein modifications that regulate calpain activity are incompletely understood. Here we show that calpains are regulated by KCTD7, a cytosolic protein of previously uncharacterized function whose pathogenic mutations result in epilepsy, progressive ataxia, and severe neurocognitive deterioration. We show that KCTD7 works in complex with Cullin-3 and Rbx1 …

Does Positive Psychology Coaching Improve Trainee Well-Being? Evidence From A Longitudinal Professional Development Coaching Program In A Cohort Of Pediatric Trainees, Benjamin Nelson, Jacqueline T. Chu, Michael G. Healy, Yoon Soo Park, Kerri Palamara Md

Journal of Wellness

Introduction: Trainee burnout is common and evidence supporting the effectiveness of well-being interventions for this population is limited. We studied the effect of a longitudinal coaching program grounded in positive psychology on measures of pediatric trainee well-being.

Methods: Pediatric interns and fellows (n = 67) were enrolled in a positive psychology coaching program in 2017-2019. Pediatric faculty (n = 23) underwent training and were paired with trainees outside their field of interest. Trainees were surveyed at the beginning and end of the program to assess burnout and well-being, and key skills necessary to achieve well-being.

Results: Thirty-one …

Health-Related Quality Of Life In Adolescents And Young Adults With Cancer Who Received Radiation Therapy: A Scoping Review, Kelsey L Corrigan, Bryce B Reeve, John M Salsman, Elizabeth J Siembida, Lauren M Andring, Yimin Geng, Ramez Kouzy, J Andrew Livingston, Susan K Peterson, Andrew J Bishop, Grace L Smith, Jillian R Gunther, Susan K Parsons, Michael Roth

Faculty, Staff and Student Publications

Purpose: Radiation therapy (RT) is a critical component of treatment for adolescents and young adults (AYAs, age 15-39 years old) diagnosed with cancer. Limited prior studies have focused on AYAs receiving RT despite the potentially burdensome effects of RT. We reviewed the literature to assess health-related quality of life (HRQOL) in AYAs with cancer who received RT.

Methods: The MEDLINE, EMBASE, and Web of Science databases were searched in January 2022 to identify studies that analyzed HRQOL measured by patient-reported outcomes in AYAs who received RT. After title (n = 286) and abstract (n = 58) screening and full-text review …

Cervicovaginal Microbiota Profiles In Precancerous Lesions And Cervical Cancer Among Ethiopian Women, Brhanu Teka, Kyoko Yoshida-Court, Ededia Firdawoke, Zewditu Chanyalew, Muluken Gizaw, Adamu Addissie, Adane Mihret, Lauren E Colbert, Tatiana Cisneros Napravnik, Molly B El Alam, Erica J Lynn, Melissa Mezzari, Jhingran Anuja, Eva Johanna Kantelhardt, Andreas M Kaufmann, Ann H Klopp, Tamrat Abebe

Faculty, Staff and Student Publications

Although high-risk human papillomavirus infection is a well-established risk factor for cervical cancer, other co-factors within the local microenvironment may play an important role in the development of cervical cancer. The current study aimed to characterize the cervicovaginal microbiota in women with premalignant dysplasia or invasive cervical cancer compared with that of healthy women. The study comprised 120 Ethiopian women (60 cervical cancer patients who had not received any treatment, 25 patients with premalignant dysplasia, and 35 healthy women). Cervicovaginal specimens were collected using either an Isohelix DNA buccal swab or an Evalyn brush, and ribosomal RNA sequencing was used …

Convergent Deployment Of Ancestral Functions During The Evolution Of Mammalian Flight Membranes, Charles Y Feigin, Jorge A Moreno, Raul Ramos, Sarah A Mereby, Ares Alivisatos, Wei Wang, Renée Van Amerongen, Jasmin Camacho, John J Rasweiler, Richard R Behringer, Bruce Ostrow, Maksim V Plikus, Ricardo Mallarino

Faculty, Staff and Student Publications

Lateral flight membranes, or patagia, have evolved repeatedly in diverse mammalian lineages. While little is known about patagium development, its recurrent evolution may suggest a shared molecular basis. By combining transcriptomics, developmental experiments, and mouse transgenics, we demonstrate that lateral Wnt5a expression in the marsupial sugar glider (Petaurus breviceps) promotes the differentiation of its patagium primordium. We further show that this function of Wnt5a reprises ancestral roles in skin morphogenesis predating mammalian flight and has been convergently used during patagium evolution in eutherian bats. Moreover, we find that many genes involved in limb development have been redeployed during …

Identifying Occupational Health And Safety Risks Among Environmental Health Officers In Australia And New Zealand Through An Online Survey, Garry Dine, Sue Reed, Jacques Oosthuizen, Edmore Masaka

Research outputs 2022 to 2026

To identify the occupational health and safety (OHS) risks among environmental health officers (EHOs) in Australia and New Zealand. The objectives were to profile and compare OHS experiences from different countries and regions to gain a regional perspective on OHS hazards that impact EHOs. An online hazard exposure survey was conducted among 339 EHOs (Australia: n = 301, 88.8%; New Zealand: n = 38, 11.2%). The Mann-Whitney U test was used to compare 2 ordinal data groups, the Kruskal-Wallis H test was used for more than 2 ordinal groups, and the independent samples t test was used to compare the …

Calpain Activity Is Negatively Regulated By A Kctd7-Cullin-3 Complex Via Non-Degradative Ubiquitination, Jaiprakash Sharma, Shalaka Mulherkar, Uan-I Chen, Yan Xiong, Lakshya Bajaj, Byoung-Kyu Cho, Young Ah Goo, Hon-Chiu Eastwood Leung, Kimberley F Tolias, Marco Sardiello

Faculty, Staff and Students Publications

Calpains are a class of non-lysosomal cysteine proteases that exert their regulatory functions via limited proteolysis of their substrates. Similar to the lysosomal and proteasomal systems, calpain dysregulation is implicated in the pathogenesis of neurodegenerative disease and cancer. Despite intensive efforts placed on the identification of mechanisms that regulate calpains, however, calpain protein modifications that regulate calpain activity are incompletely understood. Here we show that calpains are regulated by KCTD7, a cytosolic protein of previously uncharacterized function whose pathogenic mutations result in epilepsy, progressive ataxia, and severe neurocognitive deterioration. We show that KCTD7 works in complex with Cullin-3 and Rbx1 …

Defects In Lipid Homeostasis Reflect The Function Of Tango2 In Phospholipid And Neutral Lipid Metabolism, Agustin Leonardo Lujan, Ombretta Foresti, Conor Sugden, Nathalie Brouwers, Alex Mateo Farre, Alessio Vignoli, Mahshid Azamian, Alicia Turner, Jose Wojnacki, Vivek Malhotra

Faculty, Staff and Students Publications

We show that TANGO2 in mammalian cells localizes predominantly to mitochondria and partially at mitochondria sites juxtaposed to lipid droplets (LDs) and the endoplasmic reticulum. HepG2 cells and fibroblasts of patients lacking TANGO2 exhibit enlarged LDs. Quantitative lipidomics revealed a marked increase in lysophosphatidic acid (LPA) and a concomitant decrease in its biosynthetic precursor phosphatidic acid (PA). These changes were exacerbated in nutrient-starved cells. Based on our data, we suggest that TANGO2 function is linked to acyl-CoA metabolism, which is necessary for the acylation of LPA to generate PA. The defect in acyl-CoA availability impacts the metabolism of many other …

A Randomized Phase I/Ii Safety And Immunogenicity Study Of The Montanide-Adjuvanted Sars-Cov-2 Spike Protein-Rbd-Fc Vaccine, Aks-452, Eline A Feitsma, Yester F Janssen, Hendrikus H Boersma, Yannick Van Sleen, Debbie Van Baarle, David G Alleva, Thomas M Lancaster, Thillainaygam Sathiyaseelan, Sylaja Murikipudi, Andrea R Delpero, Melanie M Scully, Ramya Ragupathy, Sravya Kotha, Jeffrey R Haworth, Nishit J Shah, Vidhya Rao, Shashikant Nagre, Shannon E Ronca, Freedom M Green, Ari Aminetzah, Frans Sollie, Schelto Kruijff, Maarten Brom, Gooitzen M Van Dam, Todd C Zion

Faculty, Staff and Students Publications

BACKGROUND: Previous interim data from a phase I study of AKS-452, a subunit vaccine comprising an Fc fusion of the respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein receptor binding domain (SP/RBD) emulsified in the water-in-oil adjuvant, Montanide™ ISA 720, suggested a good safety and immunogenicity profile in healthy adults. This phase I study was completed and two dosing regimens were further evaluated in this phase II study.

METHODS: This phase II randomized, open-labelled, parallel group study was conducted at a single site in The Netherlands with 52 healthy adults (18 - 72 years) receiving AKS-452 subcutaneously at one 90 µg …

Exploration Of Data Science Toolbox And Predictive Models To Detect And Prevent Medicare Fraud, Waste, And Abuse, Benjamin P. Goodwin, Adam Canton, Babatunde Olanipekun

SMU Data Science Review

The Federal Department of Health and Human Services spends approximately $830 Billion annually on Medicare of which an estimated $30 to $110 billion is some form of fraud, waste, or abuse (FWA). Despite the Federal Government’s ongoing auditing efforts, fraud, waste, and abuse is rampant and requires modern machine learning approaches to generalize and detect such patterns. New and novel machine learning algorithms offer hope to help detect fraud, waste, and abuse. The existence of publicly accessible datasets complied by The Centers for Medicare & Medicaid Services (CMS) contain vast quantities of structured data. This data, coupled with industry standardized …

Novel Cause Of Late Atrial Septal Defect Devices Embolization, Wejdan Ba-Atiyah, Hala Gabel, Ahmad Jamjoom, Jameel Al-Ata

Journal of the Saudi Heart Association

Transcatheter closure of septal defects using specialized devices is a common procedure that has a high success rate. Embolization of Atrial septal defect devices is a known complication seen at a rate of 0.5%. We report a case of late ASD device occluder embolization immediately after brain MRI with clinical consequences and intraoperative evidence of right atrial wall thermal injury. To our knowledge Atrial septal occluder (ASO) device embolization post magnetic resonance imaging (MRI) was not reported before, although theoretically possible and that's why six to eight weeks post device implantation MRI is prohibited even with current MRI compatible devices.

Adaptation Of The Love–Hate Scale For Sports Fans Into Turkish: A Validity And Reliability Study, Sercan Kural, Oguz Ozbek, Bulent Gurbuz

Baltic Journal of Health and Physical Activity

Introduction: This research has been conducted so it can help to understand the feelings of love and hatred towards the opposing team and their supporters of football club fans and to determine and control the fans’ aggression. Objective: This study aims to adapt the Love–Hate Scale for Sports Fans (LHSSF) to the Turkish context to evaluate the fanatic (love and hate) feelings of football fans. Methods: The study groups consisted of 205 football fans aged 18–58 years (mean age = 30.11). The original version of the scale consists of seven items and two sub-dimensions. To test the construct validity of …

Physical Activity Among Adults With Psychiatric Illness In Karachi, Pakistan: A Survey Based Research, Aneeta Jevtani, Erum Perveen, Mustafa Uroosa, Nazia Zeya, Farkhanda Emad, Fareeha Kanwal, Mahum Azhaar, Faisal Yamin

Baltic Journal of Health and Physical Activity

Introduction: In Pakistan, psychological wellbeing is still considered a stigma and has limited resources to provide maximum care. Individuals with mental illness struggle with maintaining their sedentary behaviors and have poor wellbeing. The aim of the study is to investigate the physical activity among individuals with a psychiatric illness. Materials and Methods: A sample data of 144 outpatients, diagnosed with a psychiatric illness were collected from the Outpatient Department (OPD) of a public sector psychiatric set-up in Karachi, Pakistan. The participants were assessed with the International Physical Activity Questionnaire (IPAQ). Results: Females with a psychiatric illness were found to be …

Utilizing Telehealth To Decrease Hospital Readmissions For Heart Failure Patients, Madison Geib, Jo Loomis

DNP Qualifying Manuscripts

Abstract

Background: Without proper education, heart failure (HF) is very difficult to manage. A lack of education and proper management of HF can lead to frequent hospital readmissions, decreased quality of life, and early morbidity and mortality.

Objective: Through literature review, this paper aims to identify the benefits of implementing telehealth education for HF patients in order to decrease hospital readmissions.

Methods: A range of relevant articles were analyzed and summarized in this literature review. An extensive literature search was performed and systematic reviews, meta-analyses, critically appraised research studies, qualitative, and peer-reviewed research studies were included.

Results: Ten articles met …

2023-03-23 Michiganoverview_Covidoutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/outbreak-reporting.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

COVID-19 outbreaks are generally defined as two or more cases with a link by place and time indicating a shared exposure outside of a household. Local health departments report the number of new and ongoing outbreaks they are investigating by the setting of the outbreak. New outbreaks are those outbreaks that were first identified during the current reporting week. Ongoing outbreaks are …

04-07-23 Hsc Committee Notice, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Clinically Applicable Sociolinguistic Assessment For Cognitive-Communication Disorders, Louise C. Keegan, Jerry K. Hoepner, Leanne Togher, Mary Kennedy

Communication Sciences and Disorders Faculty Articles and Research

Purpose:

The third International Cognitive-Communication Disorders Conference was held in early 2022, providing an opportunity for researchers and clinicians to discuss management of cognitive-communication disorders (CCDs). Presentations that addressed social discourse initiated broader conversations about implementing sociolinguistic methods in research and clinical contexts. Given the heterogeneity of CCDs and sociocultural contexts, a person-centered approach is needed. Sociolinguistic methods are inherently relevant and salient to the individual's communication context and partners. Sociolinguistic analyses provide information about language skills, cognitive-communication skills, and social cognition. The purpose of this article is to share a model of social communication and provide descriptions of current …

Child Traumatic Stress And Covid-19: The Impact Of The Pandemic On A Clinical Sample Of Children In Trauma Treatment, Ginny Sprang, Jessica G. Eslinger, Adrienne Whitt-Woosley, Stephanie Gusler, Tracy Clemans

Psychiatry Faculty Publications

Given the scope and duration of the COVID-19 pandemic, it is not surprising that research has documented negative effects to youth’s mental health. Yet, there is negligible research on the impact of the pandemic among clinical samples of youth receiving treatment for pre-existing trauma exposure and symptoms. The current study investigates COVID-19 as an index trauma, and if prior traumatic stress scores mediate the relationship between pandemic-related exposure and subsequent traumatic stress. Methods: This is a study of 130 youth ages 7–18 receiving trauma treatment at an academic medical center. The University of California Los Angeles Post-traumatic Stress Disorder-Reaction Index …

Assessment Of Kamap Man Tru Men’S Health And Gender Program At Decreasing Partner To Partner Hiv/Aids Transmission In Papua New Guinea Deriving From Men’S Sexual And Reproductive Cultural Behaviors And Perceptions, Eliza Mabey

Health Sciences Student Scholarship

Papua New Guinea has the highest incidence and prevalence of human immunodeficiency virus in the Pacific. Men are more likely to die of AIDS-related illnesses, less likely to get HIV testing, and less likely to access antiretroviral therapy, than women. Initiatives such as the Kamap Man Tru Men’s Health and Gender Program educate members of PNG communities on sexual health, gender-based violence, and healthy relationships. Preventing HIV before it is transmitted is cost-effective, sustainable, and socio-culturally appropriate. Key determinants of the spread of HIV are clearly associated with gender, violence, and sexuality. As a result of Papua New Guinea’s cultural …

Evidence That Increasing Serum 25(Oh)D Concentrations To 30 Ng/Ml In The Kingdom Of Saudi Arabia And The United Arab Emirates Could Greatly Improve Health Outcomes, William B. Grant, Fatme Al Anouti, Barbara J. Boucher, Hana M. A. Fakhoury, Meis Moukayed, Stefan Pilz, Nasser M. Al-Daghri

All Works

Accumulating evidence supports the potential protective effects of vitamin D against chronic diseases such as Alzheimer’s disease, autoimmune diseases, cancers, cardiovascular disease (ischaemic heart disease and stroke), type 2 diabetes, hypertension, chronic kidney disease, stroke, and infectious diseases such as acute respiratory tract diseases, COVID-19, influenza, and pneumonia, as well as adverse pregnancy outcomes. The respective evidence is based on ecological and observational studies, randomized controlled trials, mechanistic studies, and Mendelian randomization studies. However, randomized controlled trials on vitamin D supplementation have largely failed to show benefits, probably due to poor design and analysis. In this work, we aim to …

Cardiovascular Health Through Vitamin C Intake, Elizabeth A. Moxley

Faculty Articles, Papers, and Other Scholarship

Vitamin C, or ascorbic acid, is a water-soluble vitamin, coenzyme, and cofactor in the biosynthesis of carnitine, a molecule that is required to oxidize fatty acids or convert fat in the body into energy. An adequate intake of vitamin C helps to facilitate osteoblast and osteodentin formation, synthesize catecholamines, reduce urinary folic acid excretion, and improve the absorption of dietary iron.¹ Since humans lack endogenous synthesis of vitamin C, it is necessary to obtain adequate levels in the diet. Vitamin C is found in foods such as citrus fruits (oranges, kiwi, lemon, grapefruit), tomatoes, bell peppers, strawberries, white potatoes, …

Design And Preclinical Evaluation Of A Universal Sars-Cov-2 Mrna Vaccine, Jane Qin, Ju Hyeong Jeon, Jiangsheng Xu, Laura Katherine Langston, Ramesh Marasini, Stephanie Mou, Brian Montoya, Carolina R Melo-Silva, Hyo Jin Jeon, Tianyi Zhu, Luis J. Sigal, Renhuan Xu, Huabin Zhu

Department of Microbiology and Immunology Faculty Papers

Because of the rapid mutations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an effective vaccine against SARS-CoV-2 variants is needed to prevent coronavirus disease 2019 (COVID-19). T cells, in addition to neutralizing antibodies, are an important component of naturally acquired protective immunity, and a number of studies have shown that T cells induced by natural infection or vaccination contribute significantly to protection against several viral infections including SARS-CoV-2. However, it has never been tested whether a T cell-inducing vaccine can provide significant protection against SARS-CoV-2 infection in the absence of preexisting antibodies. In this study, we designed and evaluated …

Antidepressant Augmentation Versus Switch In Treatment-Resistant Geriatric Depression, Eric J Lenze, Pilar Cristancho, Torie R Gettinger, Emily Lenard, J Philip Miller, Ginger E Nicol, Vy T Pham, Lei Yang, Et Al.

2020-Current year OA Pubs

BACKGROUND: The benefits and risks of augmenting or switching antidepressants in older adults with treatment-resistant depression have not been extensively studied.

METHODS: We conducted a two-step, open-label trial involving adults 60 years of age or older with treatment-resistant depression. In step 1, patients were randomly assigned in a 1:1:1 ratio to augmentation of existing antidepressant medication with aripiprazole, augmentation with bupropion, or a switch from existing antidepressant medication to bupropion. Patients who did not benefit from or were ineligible for step 1 were randomly assigned in step 2 in a 1:1 ratio to augmentation with lithium or a switch to …