Medicine and Health Sciences Commons^™

Impact Of Passive Leg Movement On Lower Limb Vascular Function In Patients With A Spinal Cord Injury, Christian D. Sanchez Tato, Elizabeth J. Pekas, Michael F. Allen, Cody P. Anderson, Song-Young Park

UNO Student Research and Creative Activity Fair

Background: Individuals with spinal cord injuries (SCI) are at a greater risk for developing cardiovascular diseases. Of note, post injury mediated increases in physical inactivity leads to muscle atrophy, which also results in vascular dysfunction in this population. Although a growing body of evidence suggests that passive leg movement (PLM) may be a useful exercise modality to improve peripheral blood flow and skeletal muscle activation in individuals with limited mobility, few studies have examined the impact of PLM on local skeletal muscle blood flow. Therefore, there is a need to examine the impact of PLM on lower limb vascular function …

The Effects Of Demographics And Risk Factors On The Morphological Characteristics Of Human Femoropopliteal Arteries, Sayed Ahmadreza Razian, Majid Jadidi, Alexey Kamenskiy

UNO Student Research and Creative Activity Fair

Background: Disease of the lower extremity arteries (Peripheral Arterial Disease, PAD) is associated with high morbidity and mortality. During disease development, the arteries adapt by changing their diameter, wall thickness, and residual deformations, but the effects of demographics and risk factors on this process are not clear.

Methods: Superficial femoral arteries from 736 subjects (505 male, 231 female, 12 to 99 years old, average age 51±17.8 years) and the associated demographic and risk factor variables were used to construct machine learning (ML) regression models that predicted morphological characteristics (diameter, wall thickness, and longitudinal opening angle resulting from the …

Impact Of Sex On Macrovascular Endothelial Function During Prolonged Sitting With A Mild Hypercapnic Environemnt, Andres Benitez-Albiter, Michael Allen, Elizabeth J. Pekas, Cody P. Anderson, Song-Young Park

UNO Student Research and Creative Activity Fair

IMPACT OF SEX ON MACROVASCULAR ENDOTHELIAL FUNCTION DURING PROLONGED SITTING WITH A MILD HYPERCAPNIC ENVIORNMENT

Andres Benitez-Albiter¹, Michael F. Allen¹, Elizabeth J. Pekas¹, Cody P. Anderson¹, and Song-Young Park¹

1 - School of Health & Kinesiology University of Nebraska Omaha, Omaha, NE

Introduction: Prolonged sitting (PS), defined as sitting for 2+ hours at a time[SYP1] , has been identified as an independent risk factor for cardiovascular disease. It has been well-documented that an acute PS bout can impair macro- and microvascular dysfunction in healthy young individuals. Recently, we reported that …

Effect Of Dual Tasking And Levodopa-Induced Dyskinesia On Postural Sway In People With Parkinson's Disease, Joseph Ayotunde Aderonmu, Carolin Curtze

UNO Student Research and Creative Activity Fair

Parkinson's disease (PD) is a neurodegenerative disorder that results in motor impairments such as gait and balance deficits. Levodopa is one of the most effective drugs in treating the slowness of movement in individuals with PD. However, the long-term use of levodopa in treating PD often causes undesirable involuntary and uncontrollable movements, known as levodopa-induced dyskinesia (LID). LID is a known cause of increased postural sway. Yet, the relative contribution of the body segments often affected by dyskinesia to postural sway is unknown. We aimed to investigate the contribution of different body segments to postural sway in PD for individuals …

Cardiac Rgs Proteins In Human Heart Failure And Atrial Fibrillation: Focus On Rgs4., Jordana I. Borges, Malka S. Suster, Anastasios Lymperopoulos

HPD Articles

The regulator of G protein signaling (RGS) proteins are crucial for the termination of G protein signals elicited by G protein-coupled receptors (GPCRs). This superfamily of cell membrane receptors, by far the largest and most versatile in mammals, including humans, play pivotal roles in the regulation of cardiac function and homeostasis. Perturbations in both the activation and termination of their G protein-mediated signaling underlie numerous heart pathologies, including heart failure (HF) and atrial fibrillation (AFib). Therefore, RGS proteins play important roles in the pathophysiology of these two devasting cardiac diseases, and several of them could be targeted therapeutically. Although close …

The Relationship Between Recent Csd Graduates' Comfort And Training With Aac And Their Knowledge Of Aac, Delanie Amend, B.S.

Theses & Honors Papers

The purpose of this research was to investigate the perspectives of recent Communication Sciences and Disorders (CSD) graduate students regarding their comfort and training around Augmentative and Alternative Communication (AAC) and examine the Dunning-Kruger effect between recent CSD graduates’ knowledge with AAC versus their perceived expertise of AAC. The researcher distributed an online survey via email, social media, American Speech-Language- Hearing Association (ASHA) Special Interest Groups to individuals who graduated from a CAA- accredited Speech-Language Pathology master’s program with a graduation year of 2018-2022 who now currently hold either their Certificate of Clinical Competency (CCC-SLP) or their Clinical Fellowship license …

Sensor-Monitored Compliance Following Rcr And Effects On Postoperative Prognosis, Phillip Westbrook

Yale School of Medicine Physician Associate Program Theses

Rehabilitation in the immediate postoperative period after surgical rotator cuff repair is critical for long-term patient outcomes. This rehabilitation typically consists of six weeks of immobilization with a sling following surgery to optimize tendon-to-bone healing, but the benefit of this has been debated in recent years. The optimal immobilization period is difficult to determine because patient compliance with immobilization protocols varies. Subjective measures from patients regarding compliance are often unreliable, suggesting a need for a more objective approach. In this prospective cohort study, we will use temperature sensors to monitor sling wearing times and assess the effect of patient compliance …

Dichloroacetate As A Metabolic Treatment For Glioblastoma, Megan Macia

Yale School of Medicine Physician Associate Program Theses

Glioblastoma is the most common aggressive primary brain tumor in adults, and there is no current standard of care for progression. The Warburg effect is a known part of cancer’s metabolic reprogramming and has been studied as a possible target for limiting tumor growth. Dichloroacetate, a pyruvate dehydrogenase kinase inhibitor, has been proposed as a treatment for glioblastoma, and the drug has had success in phase 1 trials. The proposed study is an open-label, randomized phase 2 clinical trial. Participants will be randomized to oral dichloroacetate, with dosing based on genetic testing, or to a control group treated with lomustine. …

A Cross Sectional Review: Effects Of Dehydration On Subdural Hematoma Risk In Athletes, Lina Nguyen

Yale School of Medicine Physician Associate Program Theses

Subdural hematomas are precedent to nearly all catastrophic head injuries in athletics, and are a leading cause of death and morbidity in sports. While known risk factors exist, cases still occur in young, healthy athletes without clear predisposition– occasionally without a precipitating traumatic event. Athletes are at increased susceptibility for dehydration, and the effects of inadequate fluid status on subdural risk is unknown. This study aims to elucidate the relationship between dehydration during athletic activity and subdural hematoma formation. We propose a cross-sectional study utilizing Yale New Haven Hospital electronic medical records, where we compare hydration status at emergency room …

Access To Gender-Affirming Voice Services Among Emerging Adults In The Gender-Expansive Community, Erin O. Wind

Theses & Honors Papers

Emerging adulthood, occurring between the ages of 18 to 25, is a time of significant identity exploration. This age group has the highest prevalence of individuals who are transgender or nonbinary; however, there is minimal current research on access to gender-affirming voice services among this demographic. This study utilized a healthcare access framework by Levesque et al. (2013) to analyze organizational barriers to care including approachability, acceptability, availability, affordability, and appropriateness for this population.

The researchers collected data from 104 participants with an electronic survey. Survey data showed most participants (64%) are aware of and desire gender-affirming voice services. Of …

2023-03-24_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Glycemic Challenge Is Associated With The Rapid Cellular Activation Of The Locus Ceruleus And Nucleus Of Solitary Tract: Circumscribed Spatial Analysis Of Phosphorylated Map Kinase Immunoreactivity, Arshad Khan

Selected Works Temporary Series

Rodent studies indicate that impaired glucose utilization or hypoglycemia is associated with the cellular activation of neurons in the medulla (Winslow, 1733) (MY), believed to control feeding behavior and glucose counterregulation. However, such activation has been tracked primarily within hours of the challenge, rather than sooner, and has been poorly mapped within standardized brain atlases. Here, we report that, within 15 min of receiving 2-deoxy-D-glucose (2-DG; 250 mg/kg, i.v.), which can trigger glucoprivic feeding behavior, marked elevations were observed in the numbers of rhombic brain (His, 1893) (RB) neuronal cell profiles immunoreactive for the cellular activation marker(s), phosphorylated p44/42 MAP …

Neonatal Abstinence Syndrome: An Update On The Cost And Length Of Stay Associated With Treatment During The Hospital Stay, Kimberly Stanfield, Kylie Day, Sarah M. Clemente, Alberto Coustasse

Management Faculty Research

Neonatal Abstinence Syndrome (NAS) has been costly for the healthcare system; every 19 minutes, a newborn was diagnosed in 2021. Medically Assisted Treatment (MAT)) for expecting mothers has been shown to decrease costs and length of stay for newborns NAS. This study utilized a literature review and a semi-structured interview. The research showed that medically assisted treatment with methadone or buprenorphine during pregnancy decreased costs, LOS, and severity of symptoms for newborns diagnosed with NAS. The findings showed a positive association between lower costs for the initial stay of infants whose mothers received MAT. MAT during pregnancy has been shown …

Disease Risk Of Reintroducing Primates Confiscated From The Illegal Wildlife Trade, Ana Patricia Mendoza Becerra

Dissertations

Zoonotic infections are easily shared between human and other primates, and thus primate trafficking poses a high risk of introducing zoonotic pathogens into urban environments as well as spreading human-associated diseases into natural environments when infected primates are released. The magnitude of these risks has not been thoroughly studied in the context of primate trafficking and rehabilitation of Neotropical primates. In this dissertation, I address some knowledge gaps in disease risk analysis of reintroducing trafficked primates. In chapter 1, I describe the dynamics, diversity, and composition of live wildlife trafficking in urban markets in Peru. I found these markets are …

Harm Reduction In West Virginia: Do Needle Exchange Programs Reduce Disease And Decrease Costs?, Katie Duty, Amber Graves, Anthony Uriate, Stacie Deslich, Alberto Coustasse, Thomas Norton

Management Faculty Research

Needle Exchange Programs (NEP)s were created to help users exchange used needles for new sterile ones and become aware of treatment and rehabilitation options. This study aimed to determine the effectiveness of NEPs and their impact on reducing HIV and Hepatitis C infections in West Virginia and decreasing health care costs for the community. Based on studies conducted on the past implementation of needle exchange programs, it is suggested that there has been evidence that closing these programs can have a broad societal impact on the spread of HIV and hepatitis C and the associated costs. In addition, the community …

Magnet Hospitals: An Update On The Impact On Nursing Burnout, Jonathan Settle, Michael Davis, Alberto Coustasse

Management Faculty Research

Nurse burnout has been associated with worsened outcomes for nurses, such as increased turnover or quitting and lower job satisfaction. The purpose of this research was to examine Magnet-designation status in U.S. hospitals, specifically shared governance and structural empowerment, and its effects on nurse burnout, nurse turnover, and job satisfaction of nurses. This study utilized a literature review complemented by two semi-structured interviews. The results showed that Magnet hospitals kept lower levels of burnout, better job satisfaction, and less turnover than non-Magnet hospitals, but this was only the case for some studies of Magnet hospitals. Some outcomes could be attributed …

A Focused Review Of Statistical Practices For Relating Radiation Dose-Volume Exposure And Toxicity, Andrew M. Mcdonald, Craig S. Schneider, John M. Stahl, Robert A. Oster, Richard A. Popple, Charles S. Mayo

APC Fund

Purpose Relating dose-volume histogram (DVH) information to patient outcomes is critical for outcomes research in radiation oncology, but this is statistically challenging. We performed this focused review of DVH toxicity studies to characterize current statistical approaches and determine the need for updated reporting recommendations. Methods and materials We performed a focused MEDLINE search to identify studies published in 5 radiation oncology specialty journals that associated dosimetry with toxicity outcomes in humans receiving radiotherapy between 2015 and 2021. Elements abstracted from each manuscript included the study outcome, organs-at-risk (OARs) considered, DVH parameters analyzed, summary of the analytic approach, use of multivariable …

Global Dna Adenine Methylation In Caenorhabditis Elegans After Multigenerational Exposure To Silver Nanoparticles And Silver Nitrate, Anye Wamucho, Jason M. Unrine, John May, Olga V. Tsyusko

UK CARES Faculty Publications

Multigenerational and transgenerational reproductive toxicity in a model nematode Caenorhabditis elegans has been shown previously after exposure to silver nanoparticles (Ag-NPs) and silver ions (AgNO3 ). However, there is a limited understanding on the transfer mechanism of the increased reproductive sensitivity to subsequent generations. This study examines changes in DNA methylation at epigenetic mark N6-methyl-20 -deoxyadenosine (6mdA) after multigenerational exposure of C. elegans to pristine and transformed-via-sulfidation Ag-NPs and AgNO₃ . Levels of 6mdA were measured as 6mdA/dA ratios prior to C. elegans exposure (F₀) after two generations of exposure (F₂) and two generations of …

International Society Of Sports Nutrition Position Stand: Nutritional Concerns Of The Female Athlete, Stacy T. Sims, Chad M. Kerksick, Abbie E. Smith-Ryan, Xanne A.K. Janse De Jonge, Katie R. Hirsch, Shawn M. Arent, Susan Joyce Hewlings, Susan M. Kleiner, Erik Bustillo, Jaime Tartar, Valerie Starratt, Richard B. Kreider, Casey Greenwalt, Liliana I. Rentería, Michael J. Ormsbee, Trisha Vandusseldorp, Bill I. Campbell, Douglas S. Kalman, Jose Antonio

HPD Articles

Based on a comprehensive review and critical analysis of the literature regarding the nutritional concerns of female athletes, conducted by experts in the field and selected members of the International Society of Sports Nutrition (ISSN), the following conclusions represent the official Position of the Society: 1. Female athletes have unique and unpredictable hormone profiles, which influence their physiology and nutritional needs across their lifespan. To understand how perturbations in these hormones affect the individual, we recommend that female athletes of reproductive age should track their hormonal status (natural, hormone driven) against training and recovery to determine their individual patterns and …

Gingival Transcriptomic Patterns Of Macrophage Polarization During Initiation, Progression, And Resolution Of Periodontitis, Octavio A Gonzalez, Sreenatha S Kirakodu, Linh M Nguyen, Jeffrey L Ebersole

Faculty, Staff and Student Publications

Phenotypic and functional heterogeneity of macrophages is clearly a critical component of their effective functions in innate and adaptive immunity. This investigation hypothesized that altered profiles of gene expression in gingival tissues in health, disease, and resolution would reflect changes in macrophage phenotypes occurring in these tissues. The study used a nonhuman primate model to evaluate gene expression profiles as footprints of macrophage variation using a longitudinal experimental model of ligature-induced periodontitis in animals from 3 to 23 years of age to identify aging effects on the gingival environment. Significant differences were observed in distribution of expressed gene levels for …

Glycemic Challenge Is Associated With The Rapid Cellular Activation Of The Locus Ceruleus And Nucleus Of Solitary Tract: Circumscribed Spatial Analysis Of Phosphorylated Map Kinase Immunoreactivity, Khan

Departmental Papers (Biology)

Rodent studies indicate that impaired glucose utilization or hypoglycemia is associated with the cellular activation of neurons in the medulla (Winslow, 1733) (MY), believed to control feeding behavior and glucose counterregulation. However, such activation has been tracked primarily within hours of the challenge, rather than sooner, and has been poorly mapped within standardized brain atlases. Here, we report that, within 15 min of receiving 2-deoxy-D-glucose (2-DG; 250 mg/kg, i.v.), which can trigger glucoprivic feeding behavior, marked elevations were observed in the numbers of rhombic brain (His, 1893) (RB) neuronal cell profiles immunoreactive for the cellular activation marker(s), phosphorylated p44/42 MAP …

Effect Of Different Span Lengths With Different Total Occlusal Convergences On The Accuracy Of Intraoral Scanners, Omar Elsergany

Dentistry

Purpose: The aim was to assess the effect of span lengths and total occlusal

convergence (TOC) on the accuracy of intraoral scanners .

Materials and methods: Two typodont acrylic teeth models were prepared to receive

fixed dental prostheses with three different span lengths. Span 1: between maxillary

canines; span 2: between maxillary second premolars; and span 3: between maxillary

In recent years, the employment of digital techniques in

1–4

(CAD–CAM). Obtaining a digital scan using an intrao-

ral scanner (IOS) is the first step of this digital workflow.

This technique, when compared to traditional impression

techniques, has shown exceptional accuracy …

Comparison Of General Population Vs. U.S. Military Veterans Eating Disorder Prevalence, Micah Callahan

University Honors Theses

Eating disorders disrupt the psychological wellbeing, work ability and daily functioning of many individuals. There is currently no data to compare the prevalence of eating disorders in the general public compared to the military population. The hypothesis was that the military population would be significantly higher in prevalence compared to the general population within the general eating disorder, subcategories of eating disorders and between sex. To analyze the data collected from two studies, sixteen two-proportion Z tests were conducted to determine if the proportions of DSM-V eating disorders differed within and between sex for total incidence and sub-category incidence for …

Embarking On The Journey Of Pharmacovigilance Of Homoeopathic Drugs, Subhash Kaushik

Indian Journal of Research in Homoeopathy

Embarking on the journey of pharmacovigilance of homoeopathic drugs

Knowledge, Awareness, Attitude And Practice Of Indian Homoeopathic Physicians About Pharmacovigilance In Homoeopathy: A Web-Based Cross-Sectional Study, Rajib Purkait, Baidurjya Bhattacharjee, Abhiram Banerjee, Gurudev Choubey

Indian Journal of Research in Homoeopathy

Background: Pharmacovigilance (Pv) is the science and activities relating to detecting, assessing, understanding and preventing adverse effects or any other drug-related problems. The subject is essential for developing reliable information on the safety of Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy medicines.

Objectives: This study explored the homoeopathic physicians’ knowledge, awareness, attitude and practice (KAAP) towards the Pv programme in homoeopathy.

Methods: An online cross-sectional survey was conducted among 274 Indian homoeopathic practitioners for 2 months. The study team developed the questionnaire in consultation with three subject experts and the same was circulated as a generated link among different …

Homoeopathy In The Management Of Generalised Anxiety Disorder: A Case Report, Karunakara Moorthi, Radhika P

Indian Journal of Research in Homoeopathy

Introduction: Generalised anxiety disorder (G.A.D.) is characterised by excessive, pervasive and uncontrollable worry. G.A.D. is a chronic and recurrent disorder with a low rate of remission with a considerable impact on quality of life. There is a scarcity of literature published on homoeopathy on G.A.D. This case report illustrates an improvement without recurrence of a G.A.D. case treated exclusively with homoeopathic medicine.

Case Summary: A 36-year-old man presented with anxiety about least trifles, easily irritable, palpitation, gastric disturbances, tension, excessive sweating, sleep disturbances and difficulty in concentration. After thorough case-taking, homoeopathic treatment with Lycopodium 200C and Sulphur 1000C led to …

Obviating Surgical Amputation Of Diabetic Gangrene Through Homoeopathy – A Case Report, Poojitha Ankerela, Sangeeta Belgavimath, Premalata Rotti

Indian Journal of Research in Homoeopathy

Introduction: Gangrene is defined as the decay or death of an organ or tissue due to a compromised blood supply. It is a perilous and fatal condition occurring most commonly due to diabetes. In general, people with diabetes have a significantly increased risk of lower extremity gangrene leading to amputation.

Case Summary: A 70-year-old woman presented with diabetic gangrene of her right leg and foot since 4 months. The patient complained of swelling and blackish discoloration of the right foot and leg with offensive discharging ulcers on the first and third toes. She was diagnosed with diabetic foot gangrene …

Good Clinical Practice Guidelines For Clinical Trials In Homoeopathy, Dastagiri P

Indian Journal of Research in Homoeopathy

Good Clinical Practice Guidelines for Clinical trials in Homoeopathy: Book Review

Research Highlights, Lalit Tyagi, Navita Bagdi

Indian Journal of Research in Homoeopathy

Research Highlights

Med25 Limits Master Regulators That Govern Adipogenesis, Jasmine Saunders, Kunal Sikder, Elizabeth Phillips, Anurag Ishwar, David Mothy, Kenneth B. Margulies, Jason C. Choi

Department of Medicine Faculty Papers

Mediator 25 (Med25) is a member of the mediator complex that relays signals from transcription factors to the RNA polymerase II machinery. Multiple transcription factors, particularly those involved in lipid metabolism, utilize the mediator complex, but how Med25 is involved in this context is unclear. We previously identified Med25 in a translatome screen of adult cardiomyocytes (CMs) in a novel cell type-specific model of LMNA cardiomyopathy. In this study, we show that Med25 upregulation is coincident with myocardial lipid accumulation. To ascertain the role of Med25 in lipid accumulation, we utilized iPSC-derived and neonatal CMs to recapitulate the in vivo …