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2023

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Articles 16891 - 16920 of 27519

Full-Text Articles in Medicine and Health Sciences

Are Human Papillomavirus Knowledge And Vaccine Uptake Associated With Hiv Status And Social Determinants Of Health In Young Sexual Minority Men?, Trisha L Amboree, Alan G Nyitray, John Schneider, Nick Gargurevich, Jacky Kuo, Elizabeth Y Chiao, Lu-Yu Hwang, Kayo Fujimoto Apr 2023

Are Human Papillomavirus Knowledge And Vaccine Uptake Associated With Hiv Status And Social Determinants Of Health In Young Sexual Minority Men?, Trisha L Amboree, Alan G Nyitray, John Schneider, Nick Gargurevich, Jacky Kuo, Elizabeth Y Chiao, Lu-Yu Hwang, Kayo Fujimoto

Faculty, Staff and Student Publications

This brief report examines the relationship, if any, between human immunodeficiency virus (HIV) status, and individual-level and socio-sexual partner-level factors of social determinants of health (SDOH) that are associated with human papillomavirus (HPV) knowledge and vaccine uptake in young sexual minority men (YSMM). We used data from 126 YSMM recruited by network-based sampling during 2015-2016 in Houston, Texas. Descriptive statistics and regression analyses were conducted to test the association between HIV status, SDOH, and HPV knowledge and vaccine uptake. Those living with HIV had lower odds of knowledge of HPV-associated anal cancer (OR: 0.43, 95% CI: 0.18-0.97) and knowledge of …


Intentional Self-Harm Overdoses Before And During The Covid-19 Pandemic In Adolescents Managed By A Medical Toxicology Consultation Service, Samantha L. Gaetani Md, Natalie E. Ebeling-Koning Do, Nicholas S. Imperato, Katelyn Mclain, Derek J. Fikse Do, Gillian A. Beauchamp Md, Marna R. Greenberg Do, Mph, Facep Apr 2023

Intentional Self-Harm Overdoses Before And During The Covid-19 Pandemic In Adolescents Managed By A Medical Toxicology Consultation Service, Samantha L. Gaetani Md, Natalie E. Ebeling-Koning Do, Nicholas S. Imperato, Katelyn Mclain, Derek J. Fikse Do, Gillian A. Beauchamp Md, Marna R. Greenberg Do, Mph, Facep

Department of Emergency Medicine

No abstract provided.


Importance Of Clinical Practice Guidelines (Cpgs) In Anesthesia: Who Is Responsible For Implementing It?, Fazal Hameed Khan, Yamna Sohail Apr 2023

Importance Of Clinical Practice Guidelines (Cpgs) In Anesthesia: Who Is Responsible For Implementing It?, Fazal Hameed Khan, Yamna Sohail

Department of Anaesthesia

Clinical practice guidelines (CPGs) incorporate and support clinical decisions. CPGs can improve clinicians’ and patients’ decision-making by explicitly describing and evaluating the scientific evidence, based on the potential benefits and risks underpinning clinical recommendations, making them relevant to the specific patient encounter. The number of clinical research publications have increased to the point that new medical knowledge is expected to be double every 72 days. Consequently, clinicians depend heavily on the available evidence that has been condensed into clinical CPGs by the representative institutions or societies. CPGs can have potential benefits and harms. Different groups have different opinions on whether …


Analytical Methods For Allergen Control In Food Processing, Nanju Alice Lee, Andreas Ludwig Lopata, Michelle Lisa Colgrave Apr 2023

Analytical Methods For Allergen Control In Food Processing, Nanju Alice Lee, Andreas Ludwig Lopata, Michelle Lisa Colgrave

Research outputs 2022 to 2026

Food allergy and food-related anaphylaxis have become a growing public health and food safety issue worldwide. The World Allergy Organization (WAO) estimated that 220–250 million people would live with food allergies, based on the reported prevalence of 5–8% in children and 1–2% in adults. Without a practical treatment and cure for food allergy currently available, the diligent avoidance of allergenic foods together with the prompt treatment of symptoms is the best management option available to allergic individuals. As a result, regulatory bodies in many countries mandate food allergen labelling to help allergic consumers to make informed food choices and avoid …


Combined Evaluation Of Arterial Stiffness And Blood Pressure Promotes Risk Stratification Of Peripheral Arterial Disease, Zhiyuan Wu, Yue Jiang, Qian Zhu, Haiping Zhang, Zhiwei Li, Jinqi Wang, Huiying Pan, Zheng Guo, Yulu Zheng, Xia Li, Lixin Tao, Bo Gao, Xiuhua Guo Apr 2023

Combined Evaluation Of Arterial Stiffness And Blood Pressure Promotes Risk Stratification Of Peripheral Arterial Disease, Zhiyuan Wu, Yue Jiang, Qian Zhu, Haiping Zhang, Zhiwei Li, Jinqi Wang, Huiying Pan, Zheng Guo, Yulu Zheng, Xia Li, Lixin Tao, Bo Gao, Xiuhua Guo

Research outputs 2022 to 2026

Background: Previous studies have reported the separate association of arterial stiffness (AS) and blood pressure with peripheral arterial disease (PAD). Objectives: The aim of this study was to investigate the risk stratification capacity of AS on incident PAD beyond blood pressure status. Methods: A total of 8,960 participants from Beijing Health Management Cohort were enrolled at the first health visit between 2008 and 2018 and then followed until the incidence of PAD or 2019. Elevated AS was defined as brachial-ankle pulse-wave velocity (baPWV) > 1,400 cm/s, including moderate stiffness (1,400 ≤ baPWV < 1,800 cm/s) and severe stiffness (baPWV ≥ 1,800 cm/s). PAD was defined as ankle-brachial index < 0.9. A frailty Cox model was used to calculate the HR, integrated discrimination improvement, and net reclassification improvement. Results: During follow-up, 225 participants (2.5%) developed PAD. After adjusting for confounding factors, the highest risk for PAD was observed in the group with elevated AS and blood pressure (HR: 2.253; 95% CI: 1.472-3.448). Among participants with ideal blood pressure and those with well-controlled hypertension, PAD risk was still significant for severe AS. The results remained consistent in multiple sensitivity analyses. In addition, baPWV significantly improved the predictive capacity for PAD risk beyond systolic and diastolic blood pressures (integrated discrimination improvement 0.020 and 0.190, net reclassification improvement 0.037 and 0.303). Conclusions: This study suggests the clinical importance of combined evaluation and control of AS and blood pressure for the risk stratification and prevention of PAD.


Phase Ib Study Of Talimogene Laherparepvec In Combination With Atezolizumab In Patients With Triple Negative Breast Cancer And Colorectal Cancer With Liver Metastases, J. R. Hecht, S. S. Raman, A. Chan, K. Kalinsky, J. F. Baurain, M. M. Jimenez, M. M. Garcia, M. D. Berger, U. M. Lauer, Adnan Khattak, A. Carrato, Y. Zhang, K. Liu, E. Cha, A. Keegan, S. Bhatta, C. P. Strassburg, A. Roohullah Apr 2023

Phase Ib Study Of Talimogene Laherparepvec In Combination With Atezolizumab In Patients With Triple Negative Breast Cancer And Colorectal Cancer With Liver Metastases, J. R. Hecht, S. S. Raman, A. Chan, K. Kalinsky, J. F. Baurain, M. M. Jimenez, M. M. Garcia, M. D. Berger, U. M. Lauer, Adnan Khattak, A. Carrato, Y. Zhang, K. Liu, E. Cha, A. Keegan, S. Bhatta, C. P. Strassburg, A. Roohullah

Research outputs 2022 to 2026

Background: Talimogene laherparepvec (T-VEC), a first-in-class oncolytic viral immunotherapy, enhances tumor-specific immune activation. T-VEC combined with atezolizumab, which blocks inhibitor T-cell checkpoints, could provide greater benefit than either agent alone. Safety/efficacy of the combination was explored in patients with triple negative breast cancer (TNBC) or colorectal cancer (CRC) with liver metastases.ncidence, and secondary endpoints included efficacy and AEs. Methods: In this phase Ib, multicenter, open-label, parallel cohort study of adults with TNBC or CRC with liver metastases, T-VEC (106 then 108 PFU/ml; ≤ 4 ml) was administered into hepatic lesions via image-guided injection every 21 (±3) days. Atezolizumab 1200 mg …


Cannabis, Cannabidiol, Cannabinoids, And Multigenerational Policy, Albert S. Reece, Gary Kenneth Hulse, Wei Wang Apr 2023

Cannabis, Cannabidiol, Cannabinoids, And Multigenerational Policy, Albert S. Reece, Gary Kenneth Hulse, Wei Wang

Research outputs 2022 to 2026

While classical laboratory and animal data have long established cannabinoid genotoxicity, it is only recently, with the application of modern analytical techniques, that the scale of epidemiological disease that may be attributable to cannabinoid exposure has been revealed. The importance and urgency of this work is heightened by the increased cannabis use that is accompanying the relaxation of legislation around cannabis use in many places, the widespread global movement toward cannabis legalization, and the general increase in the cannabinoid potency of available strains. . .


Identifying Associations Between Biopsychosocial Characteristics And Psychiatric Diagnoses Of Sheltered Homeless Adolescents, Caroline Kelmis, Dao Le, Andrew Ferdock, Amy B. Smith Phd, Hoonani M. Cuadrado Mspas, Pa-C, Marna R. Greenberg Do, Mph, Facep Apr 2023

Identifying Associations Between Biopsychosocial Characteristics And Psychiatric Diagnoses Of Sheltered Homeless Adolescents, Caroline Kelmis, Dao Le, Andrew Ferdock, Amy B. Smith Phd, Hoonani M. Cuadrado Mspas, Pa-C, Marna R. Greenberg Do, Mph, Facep

Department of Emergency Medicine

No abstract provided.


Hiv Prevalence And Characteristics Among Patients With Aids-Defining And Non–Aids-Defining Cancers In A Tertiary Hospital In Kenya, Diana Muturi, Sitna Mwanzi, Felix Riunga, Jasmit Shah, Reena Shah Apr 2023

Hiv Prevalence And Characteristics Among Patients With Aids-Defining And Non–Aids-Defining Cancers In A Tertiary Hospital In Kenya, Diana Muturi, Sitna Mwanzi, Felix Riunga, Jasmit Shah, Reena Shah

Internal Medicine, East Africa

Purpose: Antiretroviral therapy (ART) has resulted in a higher life expectancy of persons living with HIV. This has led to an aging population at risk for both non–AIDS-defining cancers (NADCs) and AIDS-defining cancers (ADCs). HIV testing among patients with cancer in Kenya is not routinely performed, making its prevalence undefined. The aim of our study was to determine the prevalence of HIV and the spectrum of malignancies among HIV-positive and HIV-negative patients with cancer attending a tertiary hospital in Nairobi, Kenya.

Materials and Methods: We conducted a cross-sectional study between February 2021 and September 2021. Patients with a …


A Randomized Clinical Trial Of Transgender Women Switching To B/F/Taf: The (Mo)Betta Trial, Jordan E Lake, Ana N Hyatt, Han Feng, Paula Debroy, Aaren Kettelhut, Hongyu Miao, Liming Peng, Shalender Bhasin, Susan Bell, Nahid Rianon, Todd T Brown, Nicholas T Funderburg Apr 2023

A Randomized Clinical Trial Of Transgender Women Switching To B/F/Taf: The (Mo)Betta Trial, Jordan E Lake, Ana N Hyatt, Han Feng, Paula Debroy, Aaren Kettelhut, Hongyu Miao, Liming Peng, Shalender Bhasin, Susan Bell, Nahid Rianon, Todd T Brown, Nicholas T Funderburg

Faculty, Staff and Student Publications

Background: Cardiometabolic disease in transgender women (TW) is affected by gender-affirming hormonal therapies (GAHTs), HIV, and antiretroviral therapy (ART). We evaluated the 48-week safety/tolerability of switching to bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) vs continued ART in TW on GAHT.

Methods: TW on GAHT and suppressive ART were randomized 1:1 to switch to B/F/TAF (Arm A) or continue current ART (Arm B). Cardiometabolic biomarkers, sex hormones, bone mineral density (BMD) and lean/fat mass by DXA scan, and hepatic fat (controlled continuation parameter [CAP]) were measured. Wilcoxon rank-sum/signed-rank and χ2 tests compared continuous and categorical variables.

Results: TW (Arm A n = 12, Arm …


Plasma Metabolites Associated With Cognitive Function Across Race/Ethnicities Affirming The Importance Of Healthy Nutrition, Einat Granot-Hershkovitz, Shan He, Jan Bressler, Bing Yu, Wassim Tarraf, Casey M Rebholz, Jianwen Cai, Queenie Chan, Tanya P Garcia, Thomas Mosley, Bruce S Kristal, Charles Decarli, Myriam Fornage, Guo-Chong Chen, Qibin Qi, Robert Kaplan, Hector M González, Tamar Sofer Apr 2023

Plasma Metabolites Associated With Cognitive Function Across Race/Ethnicities Affirming The Importance Of Healthy Nutrition, Einat Granot-Hershkovitz, Shan He, Jan Bressler, Bing Yu, Wassim Tarraf, Casey M Rebholz, Jianwen Cai, Queenie Chan, Tanya P Garcia, Thomas Mosley, Bruce S Kristal, Charles Decarli, Myriam Fornage, Guo-Chong Chen, Qibin Qi, Robert Kaplan, Hector M González, Tamar Sofer

Faculty, Staff and Student Publications

INTRODUCTION: We studied the replication and generalization of previously identified metabolites potentially associated with global cognitive function in multiple race/ethnicities and assessed the contribution of diet to these associations.

METHODS: We tested metabolite-cognitive function associations in U.S.A. Hispanic/Latino adults (n = 2222) from the Community Health Study/ Study of Latinos (HCHS/SOL) and in European (n = 1365) and African (n = 478) Americans from the Atherosclerosis Risk In Communities (ARIC) Study. We applied Mendelian Randomization (MR) analyses to assess causal associations between the metabolites and cognitive function and between Mediterranean diet and cognitive function.

RESULTS: Six metabolites were consistently associated …


Knowledge, Attitudes, And Beliefs About Colorectal Cancer Screening In Puerto Rico, Vivian Colón-López, Ileska M Valencia-Torres, Elsa I Ríos, Josheili Llavona, Camille Vélez-Álamo, María E Fernández Apr 2023

Knowledge, Attitudes, And Beliefs About Colorectal Cancer Screening In Puerto Rico, Vivian Colón-López, Ileska M Valencia-Torres, Elsa I Ríos, Josheili Llavona, Camille Vélez-Álamo, María E Fernández

Faculty, Staff and Student Publications

The purpose of this study was to describe the psychosocial factors influencing participation in colorectal cancer screening (CRCS) among Puerto Rican men and women. We conducted seven focus groups in metropolitan and rural areas of Puerto Rico (PR) with men and women (using gender specific groups) aged 50 to 80 years (n = 51) who were non-adherent to CRC guidelines. The focus group guide included questions related to colorectal cancer (CRC) and CRC screening knowledge, attitudes, and beliefs. We analyzed data using a modified grounded theory approach to identify emergent themes. Focus groups revealed seven major themes that represented barriers …


Oral Health Considerations For Aging Patients Living With Hiv/Aids, Madeleine Daily Dds, Susan Liu Dds, Yuna Park Dds, Mph, Ms, Emily Byington Msw, Ivette Estrada Ma, Mphil, Sunil Wadhwa Dds, Carol Kunzel Phd Apr 2023

Oral Health Considerations For Aging Patients Living With Hiv/Aids, Madeleine Daily Dds, Susan Liu Dds, Yuna Park Dds, Mph, Ms, Emily Byington Msw, Ivette Estrada Ma, Mphil, Sunil Wadhwa Dds, Carol Kunzel Phd

The New York State Dental Journal

People living with HIV/AIDS (PLWH) have an increased life expectancy due to advances in antiretroviral therapy. In 1996, the life expectancy for a 20-year old living with HIV was 39-years old; today, it is >70-years old. As life expectancy increases, PLWH are burdened with age-associated comorbidities. This paper reviews the interaction between aging and HIV and how it affects social, physical, and oral health issues. The shift in demographics presents new challenges for clinicians in how to identify, address, and manage these complex manifestations. This review summarizes how to approach HIV-related changes when providing care as a dental clinician.


Considerations When Designing And Implementing Pragmatic Clinical Trials That Include Older Hispanics, Rafael Samper-Ternent, Stephanie L Silveira, Alan Stevens, Elena Volpi, Aanand D Naik Apr 2023

Considerations When Designing And Implementing Pragmatic Clinical Trials That Include Older Hispanics, Rafael Samper-Ternent, Stephanie L Silveira, Alan Stevens, Elena Volpi, Aanand D Naik

Faculty, Staff and Student Publications

Introduction: Pragmatic clinical trials (PCTs) are designed to connect researchers with clinicians to assess the real-world effectiveness and feasibility of interventions, treatments, or health care delivery strategies in routine practice. Within PCTs larger, more representative sampling is possible to improve the external validity of the research. Older adults from underrepresented groups can benefit from PCTs given their historically lower engagement in clinical research. The current article focuses on older Hispanic adults with Alzheimer disease and related dementias (ADRDs). Older Hispanic adults represent 19% of the US population and have a higher prevalence of ADRDs than Whites. We provide data from …


Inequities In Telemedicine Use Among Patients With Stroke And Cerebrovascular Diseases: A Tricenter Cross-Sectional Study, Imama A. Naqvi, Audrey S Cohen, Youngran Kim, Jennifer Harris, Mary Carter Denny, Kevin Strobino, Nathan Bicher, Ryan A Leite, Dylan Sadowsky, Comfort Adegboye, Nnedinma Okpala, Munachi Okpala, Sean I Savitz, Randolph S Marshall, Anjail Sharrief Apr 2023

Inequities In Telemedicine Use Among Patients With Stroke And Cerebrovascular Diseases: A Tricenter Cross-Sectional Study, Imama A. Naqvi, Audrey S Cohen, Youngran Kim, Jennifer Harris, Mary Carter Denny, Kevin Strobino, Nathan Bicher, Ryan A Leite, Dylan Sadowsky, Comfort Adegboye, Nnedinma Okpala, Munachi Okpala, Sean I Savitz, Randolph S Marshall, Anjail Sharrief

Faculty, Staff and Student Publications

BACKGROUND AND OBJECTIVES: In response to the COVID-19 pandemic, outpatient stroke care delivery was rapidly transformed to outpatient evaluation through video (VTM) and telephone (TPH) telemedicine (TM) visits around the world. We sought to evaluate the sociodemographic differences in outpatient TM use among stroke patients.

METHODS: We conducted a retrospective chart review of outpatients evaluated at 3 tertiary stroke centers in the early period of the pandemic, 3/16/2020 through 7/31/2020. We compared the use of TM by patient characteristics including age, sex, race/ethnicity, insurance status, stroke type, patient type, and site. The association between TM use and patient characteristics was …


Case Studies In Physiology: Male To Female Transgender Swimmer In College Athletics, Jonathon Senefeld, Sandra K. Hunter, Doriane Coleman, Michael J. Joyner Apr 2023

Case Studies In Physiology: Male To Female Transgender Swimmer In College Athletics, Jonathon Senefeld, Sandra K. Hunter, Doriane Coleman, Michael J. Joyner

Exercise Science Faculty Research and Publications

There is current scientific and legal controversy about sports competition eligibility regulations for transgender athletes. In this case study, we quantified performances by an elite, transgender woman (male sex, female gender identity) college swimmer who competed in both the men’s and women’s National Collegiate Athletic Association (NCAA) categories. We also contextualized her performances with respect to world-record performances and contemporary elite college swimmers. These data demonstrate that the declines in freestyle swimming performances of a transgender woman after about 2 yr of reported feminizing gender-affirming hormone treatment (0.5% for the 100 to 7.3% for the 1,650 yard distance) are smaller …


Hourly Associations Between Heat Index And Heat-Related Emergency Medical Service (Ems) Calls In Austin-Travis County, Texas, Kijin Seong, Junfeng Jiao, Akhil Mandalapu Apr 2023

Hourly Associations Between Heat Index And Heat-Related Emergency Medical Service (Ems) Calls In Austin-Travis County, Texas, Kijin Seong, Junfeng Jiao, Akhil Mandalapu

Research Collection College of Integrative Studies

This paper aims to investigate the following research questions: (1) what are the hourly patterns of heat index and heat-related emergency medical service (EMS) incidents during summertime?; and (2) how do the lagged effects of heat intensity and hourly excess heat (HEH) vary by heat-related symptoms? Using the hourly weather and heat-related EMS call data in Austin-Travis County, Texas, this paper reveals the relationship between heat index patterns on an hourly basis and heat-related health issues and evaluates the immediate health effects of extreme heat events by utilizing a distributed lag non-linear model (DLNM). Delving into the heat index intensity …


A Mixed Methods Sequential Explanatory Design Study Exploring How Demographic Factors Contribute Individuals Presenting To The Emergency Department For Seizure Management, Radwa Aly Msc Apr 2023

A Mixed Methods Sequential Explanatory Design Study Exploring How Demographic Factors Contribute Individuals Presenting To The Emergency Department For Seizure Management, Radwa Aly Msc

Doctor of Philosophy in Translational Health Sciences Dissertations

Psychogenic nonepileptic seizures (PNES) mimic epileptic seizures in their clinical manifestations, but are not associated with an abnormal electrical discharge on electroencephalogram. PNES attacks are often treated and managed as likely epileptic seizures, subjecting the patient to unnecessary anti-seizure medications (ASM). Both epileptic seizures and PNES are common reasons for visiting the emergency department (ED), especially for patients without access to ambulatory care. There is growing evidence highlighting disparities in seizure care in the ED related to race, ethnicity, and socioeconomic status (SES). PNES is a significant burden to the patient and society because of the annual costs spent on …


Impacts Of Habitat, Resource Addition, And Predator Exclusion On Rodent Community Structure And Hantaviruses In The Neotropics, Briana Spruill-Harrell Apr 2023

Impacts Of Habitat, Resource Addition, And Predator Exclusion On Rodent Community Structure And Hantaviruses In The Neotropics, Briana Spruill-Harrell

Theses and Dissertations (ETD)

Understanding how climate and human land use change impacts trophic interactions is essential in the face of ongoing biodiversity loss and the continued emergence of RNA viruses and zoonosis. Human land use changes such as agricultural expansion, deforestation, and habitat degradation all have been linked to zoonotic disease emergence. Despite these commonalities, our mechanistic understanding of what drives them is lacking. Moreover, genomic surveillance in wildlife populations is critical for risk assessment and mitigation. Herein, using data collected from field studies within the Reserva Natural del Bosque Mbaracayú (RNBM), a protected area of the Interior Atlantic Forest (IAF), I examined …


Impact Of Opioid-Free Anesthesia Versus Opioid-Based Anesthesia On Time To Extubation: A Scoping Review, Mary K. Connor Rn, Bsn, Srna, Dexter Browning Rn, Bsn, Srna, Ariel Clark Rn, Bsn, Srna, Erica B. Gates Rn, Bsn, Srna, Madison T. Mccaskill Rn, Bsn, Srna, Dwayne L. Accardo Dnp, Crna, Faana Apr 2023

Impact Of Opioid-Free Anesthesia Versus Opioid-Based Anesthesia On Time To Extubation: A Scoping Review, Mary K. Connor Rn, Bsn, Srna, Dexter Browning Rn, Bsn, Srna, Ariel Clark Rn, Bsn, Srna, Erica B. Gates Rn, Bsn, Srna, Madison T. Mccaskill Rn, Bsn, Srna, Dwayne L. Accardo Dnp, Crna, Faana

Doctor of Nursing Practice Projects

Purpose/Background

Opioids during surgery have been clinically proven to lengthen the time between intubation and post-op extubation. Increased time to extubation is associated with negative patient outcomes. This scoping review aims to evaluate the use of ketamine with opioid free analgesia (OFA) versus traditional opioid usage and its outcomes on extubation times.

Methods

From September 2021 to November 2021, we conducted a literature search using the University of Tennessee Health Science Center’s (UTHSC) online library. Through the PubMed, CINAHL, Medline, and Cochrane databases, we identified seventy-one articles that matched our criteria. Of those articles, we selected twenty-five to undergo rapid …


Evaluating The Efficacy Of Medication-Assisted Treatment For First Episode Psychosis: A Scoping Review, Chanel Thomas Msn, Aprn, Fnp-Bc, Rn-Bc, Alexandra Wittenberg Bsn, Rn-Bc, Anttrenika Anderson Bsn, Rn, Tracy Mcclinton Dnp, Aprn, Agacnp-Bc, Ebp-C Apr 2023

Evaluating The Efficacy Of Medication-Assisted Treatment For First Episode Psychosis: A Scoping Review, Chanel Thomas Msn, Aprn, Fnp-Bc, Rn-Bc, Alexandra Wittenberg Bsn, Rn-Bc, Anttrenika Anderson Bsn, Rn, Tracy Mcclinton Dnp, Aprn, Agacnp-Bc, Ebp-C

Doctor of Nursing Practice Projects

Purpose/Background

The Substance Abuse and Mental Health Services Administration (SAMHSA) recommends that individuals with substance use disorder (SUD) receive medicated-assisted treatment (MAT), as a complete approach to substance use treatment (SAMHSA, 2019). However, treatment measures using combination treatment for SUD in individuals experiencing first episode psychosis (FEP) are seldom used. This scoping review assesses the efficacy of MAT in conjunction with antipsychotics compared to the use of antipsychotic monotherapy for FEP individuals on hospital readmission rates.

Methods

The authors conducted a literature review utilizing PubMed, EBSCO, Elsevier, Google Scholar, PsychINFO, and Medline from August 2020 to November 2022. Key phrases …


A Design, Development, And Evaluation Of Bio-Patch For Myocardial Tissue Repair, Yaya Zhang Apr 2023

A Design, Development, And Evaluation Of Bio-Patch For Myocardial Tissue Repair, Yaya Zhang

Theses and Dissertations (ETD)

Introduction. Ischemic heart disease (IHD) is a major concern of human health issue. The structural repair and functional recovery of injured hearts is a major challenge in the clinical setting. Preclinical studies over last 10 years have demonstrated the potential of using stem cells to treat IHD, but the efficacy of this therapy is jeopardized by uncontrollable migration and low survival of the injected stem cells. An approach based on tissue engineering enabling target-specific stem cell delivery such as cardiac patches has emerged as an alternative solution for stem cell therapy for IHD. It employs scaffold materials to engulf various …


Modulation Of Cerebral Artery Smooth Muscle Bk Channel Function By Neurosteroids, Kelsey Caroline Cleland North Apr 2023

Modulation Of Cerebral Artery Smooth Muscle Bk Channel Function By Neurosteroids, Kelsey Caroline Cleland North

Theses and Dissertations (ETD)

Voltage-gated and Ca2+ activated K+ channels of large conductance (BK) channels are essential for many key physiological processes, such as controlling the contraction of smooth muscle, including cerebrovascular smooth muscle. Importantly, BK channels are made up of a homotetramer of α subunits which associate with accessory β subunits. These β subunits alter the activity of the channel; this modulation is subunit-specific. Moreover, these accessory subunits have tissue-specific expression, such that the β1 subunit is highly expressed within cerebrovascular smooth muscle and greatly increases the open probability of BK channels. Increased BK channel open probability is linked to increased dilation of …


Vascular Mechanisms Of Rhabdomyolysis-Induced Acute Kidney Injury, Jeremiah Moyinolu Afolabi Apr 2023

Vascular Mechanisms Of Rhabdomyolysis-Induced Acute Kidney Injury, Jeremiah Moyinolu Afolabi

Theses and Dissertations (ETD)

In patients with rhabdomyolysis, the overwhelming release of myoglobin into circulation is the primary cause of kidney injury. Myoglobin causes direct kidney injury as well as severe renal vasoconstriction. An increase in renal vascular resistance (RVR) results in renal blood flow (RBF) and glomerular filtration rate (GFR) reduction, tubular injury, and acute kidney injury (AKI). The mechanisms that underlie rhabdomyolysis-induced AKI are not fully understood but may involve the local production of vasoactive mediators in the kidney. Myoglobin stimulated endothelin-1 (ET-1) production in proximal tubular cells, an effect driven by NADPH oxidase-dependent oxyradical generation. Rats subjected to glycerol-induced rhabdomyolysis also …


Molecular And Cellular Investigations Of Prader-Willi Syndrome, Anna K. Victor Apr 2023

Molecular And Cellular Investigations Of Prader-Willi Syndrome, Anna K. Victor

Theses and Dissertations (ETD)

Prader-Willi syndrome (PWS) is a complex multigenic neurodevelopmental disorder resulting in hypotonia, developmental delay, hypogonadism, sleep dysfunction and childhood onset obesity affecting 1 in 10,000 to 30,000 individuals. PWS is an imprinting disorder that is caused by a loss of expression of maternally imprinted genes in the 15q11.2-q13 region including NDN, MAGEL2, SNRPN/SNURF, and a cluster of snoRNAs. The majority of cases are caused by inheriting a paternal allele deletion of this region (65-75%) and a smaller number are caused by chromosome 15 maternal uniparental disomy (UPD) (20-30%) or imprinting center defects (1-3%). Here, we used dental pulp stem cells …


A Hybrid Assessment Of Clinical Mobility Test Items For Evaluating Individuals With Mild Traumatic Brain Injury, Peter C. Fino, Patrick G. Michielutti, Ryan Pelo, Lucy Parrington, Leland E. Dibble, Carrie W. Hoppes, Mark E. Lester, Margaret M. Weightman, Laurie A. King Apr 2023

A Hybrid Assessment Of Clinical Mobility Test Items For Evaluating Individuals With Mild Traumatic Brain Injury, Peter C. Fino, Patrick G. Michielutti, Ryan Pelo, Lucy Parrington, Leland E. Dibble, Carrie W. Hoppes, Mark E. Lester, Margaret M. Weightman, Laurie A. King

Physical Therapy Faculty Publications

Background and Purpose:

The Functional Gait Assessment (FGA) and High Level Mobility Assessment Tool (HiMAT) are clinical batteries used to assess people with mild traumatic brain injury (mTBI). However, neither assessment was specifically developed for people with mTBI; the FGA was developed to evaluate vestibular deficits, and the HiMAT was developed for individuals with more severe TBI. To maximize the sensitivity and reduce the time burden of these assessments, the purpose of this study was to determine the combination of FGA and HiMAT items that best discriminates persons with persistent symptoms from mTBI from healthy controls.

Methods:

Fifty-three symptomatic civilians …


"Life Unworthy Of Life" Aktion T4: The First Nazi Genocide, Alexander M. Remington Apr 2023

"Life Unworthy Of Life" Aktion T4: The First Nazi Genocide, Alexander M. Remington

Student Publications

Though usually viewed as a prelude to the Holocaust, the T4 euthanasia program was a distinct genocide carried out by the Third Reich’s doctors. Allowing themselves to be corrupted by eugenics and Nazi policy, the perpetrators of the Nazi euthanasia killings transformed themselves from healers to murderers. Despite public resistance led by Bishop Clemens von Galen which resulted in the cancellation of the T4 program, Nazi doctors took it upon themselves to continue euthanizing patients until the end of the war, emphasizing the legitimacy that euthanasia had acquired. The history of the T4 program, its perpetrators, and resisters is critical …


Juicemania: Interpreting Jay Kordich’S Health Empire As Religion, Deirdre M. Sullivan Apr 2023

Juicemania: Interpreting Jay Kordich’S Health Empire As Religion, Deirdre M. Sullivan

Student Publications

John “Jay” Kordich, an American “health reformer,” salesman, author, and celebrity, is best known for his recipe books on diet and health and his series of television infomercials. With his charismatic presentations and playful sense of humor, he captivated audiences with his demonstrations of various models of juicers and the delicious taste of his fresh juices. Kordich is part of a long line of health reformers, fasters, and practitioners of alternative medicine that has persisted in American culture for over 200 years. These advocates of alternative medicine have not only met a need for medical treatment, but also for religion …


Program Development Of Meaningful Work For Those With Brain Injury: A Doctoral Capstone Experience, Alyssa Mckenna Apr 2023

Program Development Of Meaningful Work For Those With Brain Injury: A Doctoral Capstone Experience, Alyssa Mckenna

Capstone Projects

In the United States there were 18,557 people diagnosed with traumatic brain injuries (TBI’s) with 49% of those injuries being caused by vehicular crashes in 2021 (Traumatic Brain Injury Model Systems National Data and Statistical Center, 2021). Those who suffer from these injuries often struggle to maintain jobs due to the symptoms resulting from the TBI’s. Vocational rehabilitation programs have been created to address the skills necessary to participate in the work environment. Vocational rehabilitation is a specialized area of occupational therapy. Recent changes have been made to Michigan’s auto no-fault insurance policy that has created a gap between this …


Social Skill Program Development: A Bottom-Up Approach, Sydney Fallis Apr 2023

Social Skill Program Development: A Bottom-Up Approach, Sydney Fallis

Capstone Projects

This Doctoral Capstone Experience involved developing and implementing a social skills group program for current clients at an occupational therapy outpatient pediatric clinic. The purpose was to provide an additional service for the clinic that clients could participate into further progress one’s social-emotional and social interaction skills. The program was developed for peers alike to learn and enhance their social skills within a realistic and supportive environment. Based on the mentor and client’s needs at Arcadia Center for OT, a social skill program was developed that integrated the bottom-up approach.