Medicine and Health Sciences Commons^™

Role Of Macrophages In Regression Of Myocardial Fibrosis Following Alleviation Of Left Ventricular Pressure Overload, Lily Neff

MUSC Theses and Dissertations

Antecedent conditions that affect the heart, such as aortic stenosis (AS), can develop into left ventricular pressure overload (LVPO). LVPO is associated with increased myocardial interstitial fibrosis, specifically fibrillar collagen, that leads to increased myocardial stiffness. Patients undergoing surgical aortic valve replacement (SAVR) to correct AS demonstrate significant but incomplete regression of fibrosis. Although current therapies normalize hemodynamic load, treatments that regress collagen content within the myocardium remain a critical need. To elucidate cellular mechanisms of this persistent fibrosis in LVPO, we utilized a transverse aortic constriction (TAC) and removal of the constriction (unTAC) murine model. Outputs were assessed for: …

The Role Of The Pcc And Acc In Autism Spectrum Disorder: A Functional Connectivity Study, Claudia Gonzalez

Honors Theses

Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that impacts behavior control and social skills. Currently, ASD diagnoses are largely qualitative; thus, having more quantitative means of identification would aid in earlier diagnosis of ASD. However, more research is needed to pinpoint observable neurobiological markers of ASD. Our study focused on the posterior cingulate cortex (PCC) due to past evidence suggesting its involvement in ASD symptomatology. The PCC has been linked to behavioral control and executive functioning. Moreover, previous studies support executive functioning’s responsibility for the repetitive and restricted behaviors (RRB) in ASD.

Method: Our study sought to …

Impact Of Intravesical Bacillus Calmette-GuéRin And Chemotherapy On The Bladder Microbiome In Patients With Non-Muscle Invasive Bladder Cancer, Kayeromi Gomez, Christopher James, Shalin Desai, Hiten Patel, Goran Rac, Chirag Doshi, Ryan Dornbier, Petar Bajic, Thomas Halverson, Gopal Gupta, Marcus Quek, Alex Gorbonos, Robert Flanigan, Alan J. Wolfe

Biostatistics Collaborative Core: Faculty Publications and Other Works

Introduction: Intravesical therapy (IVT), including Bacillus Calmette-Guérin (BCG), is the standard of care for high grade (HG) non-muscle invasive bladder cancer (NMIBC). Despite the use of IVT, many patients recur after treatment. The bladder microbiome and its role in disease processes has recently risen to prominence. We aim to characterize changes that occur in the bladder microbiome over the course of intravesical therapy and assess whether these changes correlate with outcomes in patients with NMIBC.

Methods: Patients with NMIBC undergoing induction BCG or intravesical therapy were prospectively enrolled from January 2019 to March 2020. Patients with clinical T2 or greater …

Qunex—An Integrative Platform For Reproducible Neuroimaging Analytics, Jie Lisa Ji, Jure Demšar, Clara Fonteneau, Zailyn Tamayo, Lining Pan, Aleksij Kraljic, Andraž Matkovic, Nina Purg, Markus Helmer, Anderson M. Winkler

School of Medicine Publications

Introduction: Neuroimaging technology has experienced explosive growth and transformed the study of neural mechanisms across health and disease. However, given the diversity of sophisticated tools for handling neuroimaging data, the field faces challenges in method integration, particularly across multiple modalities and species. Specifically, researchers often have to rely on siloed approaches which limit reproducibility, with idiosyncratic data organization and limited software interoperability.

Methods: To address these challenges, we have developed Quantitative Neuroimaging Environment & Toolbox (QuNex), a platform for consistent end-to-end processing and analytics. QuNex provides several novel functionalities for neuroimaging analyses, including a “turnkey” command for the reproducible deployment …

Internal Medicine Residency Newsletter, April 2023, Amani Khalouf, Amir Mahmoud, Anas M. Hashem

Rochester Regional Health authored publications and proceedings

A newsletter created by and for the Rochester General Hospital Internal Medicine Residency Program.

This issue:

1. A word from the PD
2. News & announcements
3. Resident corner
4. Awards and scholarship
5. Conferences and deadlines
6. Introducing IMRC
7. Article of the month
8. Community outreach activities
9. Happy birthday!
10. Crossword puzzle

Development, Optimization, And In Vitro/In Vivo Evaluation Of Azelaic Acid Transethosomal Gel For Antidermatophyte Activity, Ali Nasr, Noha Badawi, Yasmine Tartor, Nader Sobhy, Ali Nasr

Pharmacy

Treatment of dermatophytosis is quite challenging. This work aims to investigate the antidermatophyte action of Azelaic acid (AzA) and evaluate its efficacy upon entrapment into transethosomes (TEs) and incorporation into a gel to enhance its application. Optimization of formulation variables of TEs was carried out after preparation using the thin film hydration technique. The antidermatophyte activity of AzA-TEs was first evaluated in vitro. In addition, two guinea pig infection models with Trichophyton (T.) mentagrophytes and Microsporum (M.) canis were established for the in vivo assessment. The optimized formula showed a mean particle size of 219.8 ± 4.7 nm and a …

The Sars-Cov-2 Utr’S Intrudes Host Rbp’S And Modulates Cellular Splicing, Anjali Singh, Kush Kumar Pandey, Shubham Kumar Agrawal, Rupesh K. Srivastava, Sankar Bhattacharyya, Bhupendra Verma

Nebraska Center for Virology: Faculty Publications

SARS-CoV-2 is a novel coronavirus that causes a potentially fatal respiratory disease known as coronavirus disease (COVID-19) and is responsible for the ongoing pandemic with increasing mortality. Understanding the host-virus interaction involved in SARS-CoV-2 pathophysiology will enhance our understanding of the mechanistic basis of COVID-19 infection. The characterization of post-transcriptional gene regulatory networks, particularly pre-mRNA splicing, and the identification and characterization of host proteins interacting with the 5' and 3'UTRs of SARS-CoV-2 will improve our understanding of posttranscriptional gene regulation during SARS-CoV-2 pathogenesis. Here, we demonstrate that either SARS-CoV-2 infection or exogenous overexpression of the 5' and 3’UTRs of the …

The Impact Of Gamma Transcranial Alternating Current Stimulation (Tacs) On Cognitive And Memory Processes In Patients With Mild Cognitive Impairment Or Alzheimer’S Disease: A Literature Review, N.R. Nissim, D.V.H. Pham, T. Poddar, E. Blutt, R.H. Hamilton

Moss-Magee Rehabilitation Papers

BACKGROUND: Transcranial alternating current stimulation (tACS)-a noninvasive brain stimulation technique that modulates cortical oscillations through entrainment-has been demonstrated to alter oscillatory activity and enhance cognition in healthy adults. TACS is being explored as a tool to improve cognition and memory in patient populations with mild cognitive impairment (MCI) and Alzheimer's disease (AD).

OBJECTIVE: To review the growing body of literature and current findings obtained from the application of tACS in patients with MCI or AD, highlighting the effects of gamma tACS on brain function, memory, and cognition. Evidence on the use of brain stimulation in animal models of AD is …

Understanding Coordinated Specialty Care Best Practice Through Fidelity Practices: A Qualitative Exploration, Halley Read

Doctor of Philosophy in Translational Health Sciences Dissertations

Background: Coordinated Specialty Care (CSC) is a multidisciplinary care model for providing care to youth and young adults having their first episode of psychosis. While outcomes of CSC effectiveness are overwhelmingly positive, and widespread implementation has occurred in all US states and territories, what is CSC best practice regarding components and fidelity to the model is not clear. CSC implementation is well documented from a fidelity to the model standpoint, but the highly variable fidelity practices and versions of the model are not well understood. Nor are the experiences of those who deliver or receive care. Adding to the complexity …

Multicentre Study Protocol Comparing Standard Nrp To Developed Educational Modules For Resuscitation Of Neonates In The Delivery Room With Congenital Heart Disease (Learn-Chd)., Philip Levy, Alyssa R. Thomas, Brenda Hiu Yan Law, Chloe Joynt, Ruby Gupta, Summer Elshenawy, Danielle Reed, Leeann R. Pavlek, Jennifer Shepherd, Sharada Gowda, Beth Ann Johnson, Molly Ball, Noorjahan Ali

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Infants born with critical congenital heart defects (CCHDs) have unique transitional pathophysiology that often requires special resuscitation and management considerations in the delivery room (DR). While much is known about neonatal resuscitation of infants with CCHDs, current neonatal resuscitation guidelines such as the neonatal resuscitation programme (NRP) do not include algorithm modifications or education specific to CCHDs. The implementation of CCHD specific neonatal resuscitation education is further hampered by the large number of healthcare providers (HCPs) that need to be reached. Online learning modules (eLearning) may provide a solution but have not been designed or tested for this specific …

Essays On The Economics Of Health And Education, Thao Bui

LSU Doctoral Dissertations

This dissertation consists of three chapters on the economics of health and education. In Chapter 2, I examine the effect of prenatal exposure to Agent Orange, a dioxin- contaminated herbicide that was dispersed on a large scale in South Vietnam for military operations during the Vietnam War, on educational attainment of Vietnamese civilians. The identification strategy exploits province-by-cohort variation in the intensity of Agent Orange sprayed. I find that controlling for conventional bombing, cohorts exposed in utero to Agent Orange (who were born between 1962 and 1971) have lower educational attainment compared to other birth cohorts. The same inference is …

Dose Calculation And Prediction Methods For Gamma Knife Stereotactic Radiosurgery, Payton Hayes Stone

LSU Doctoral Dissertations

Implementation of automation routines leveraging deep learning (DL) methods has been a growing topic of interest. The focus of this work is on the Gamma Knife (GK) workflow, specifically the approximation of dose distributions from GK plan parameters and the prediction of dose distributions using DL. These works contribute towards the larger goal of treatment plan prediction and are seen as intermediate steps towards that end. The approximation of dose distributions was motivated by the closed nature of the GK system, which causes complications with the evaluation of the predictions made by the DL models. The approximation utilizes a superposition …

Evaluation Of Focal Adhesion Mediated Subcellular Curvature Sensing In Response To Engineered Extracellular Matrix

Faculty, Staff and Student Publications

Fibril curvature is bioinstructive to attached cells. Similar to natural healthy tissues, an engineered extracellular matrix can be designed to stimulate cells to adopt desired phenotypes. To take full advantage of the curvature control in biomaterial fabrication methodologies, an understanding of the response to fibril subcellular curvature is required. In this work, we examined morphology, signaling, and function of human cells attached to electrospun nanofibers. We controlled curvature across an order of magnitude using nondegradable poly(methyl methacrylate) (PMMA) attached to a stiff substrate with flat PMMA as a control. Focal adhesion length and the distance of maximum intensity from the …

Comprehensive Proteomics And Platform Validation Of Urinary Biomarkers For Bladder Cancer Diagnosis And Staging, Claudia Pedroza

Faculty, Staff and Student Publications

BACKGROUND: Bladder cancer (BC) is among the most common cancers diagnosed in men in the USA. The current gold standards for the diagnosis of BC are invasive or lack the sensitivity to correctly identify the disease.

METHODS: An aptamer-based screen analyzed the expression of 1317 proteins in BC compared to urology clinic controls. The top hits were subjected to systems biology analyses. Next, 30 urine proteins were ELISA-validated in an independent cohort of 68 subjects. Three of these proteins were next validated in an independent BC cohort of differing ethnicity.

RESULTS: Systems biology analysis implicated molecular functions related to the …

Astrovirology: How Viruses Enhance Our Understanding Of Life In The Universe, Gareth Trubl, Ken Stedman, Kathryn F. Bywaters, Emily E. Matula, Pacifica Sommers, Simon Roux, Nancy Merino, Multiple Additional Authors

Biology Faculty Publications and Presentations

Viruses are the most numerically abundant biological entities on Earth. As ubiquitous replicators of molecular information and agents of community change, viruses have potent effects on the life on Earth, and may play a critical role in human spaceflight, for life-detection missions to other planetary bodies and planetary protection. However, major knowledge gaps constrain our understanding of the Earth’s virosphere: (1) the role viruses play in biogeochemical cycles, (2) the origin(s) of viruses and (3) the involvement of viruses in the evolution, distribution and persistence of life. As viruses are the only replicators that span all known types of nucleic …

Beyond The Bmi: Expanding Quantitative Methods To Study Health For All Bodies, Kieran Chase, Daniel Oron

OHSU-PSU School of Public Health Annual Conference

The public health field is beginning to reckon with its role in perpetuating and reinforcing systemic anti-fatness. Emerging evidence for the devastating health impacts of stigma call into question decades of research and policy that labels the size of people’s bodies as diseased. However, even as we acknowledge the harmful effects of stigma, the field is materially and institutionally invested in a health paradigm that centers weight loss and size-related proxies for health, such as the BMI. Public health scholars interested in questions related to nutrition, chronic disease, and exercise must begin to expand their research focus to imagine non-stigmatizing …

Serotonin And Migraine, Sophia A. Kogan

OHSU-PSU School of Public Health Annual Conference

Migraine, experienced by more than 1 billion people, is the second leading cause of disability worldwide. It is a physiologically complex disorder with nervous, vascular, and inflammatory components, and is associated with genetic factors and environmental influences. Migraine triggers are poorly understood, and sufferers have little control in preventing migraines from occurring. The aim of this review is to bridge the physiological migraine processes with lifestyle behaviors that can be modified by individuals, focusing on serotonin.

Migraines can be initiated when an external event triggers the release of vasodilators such as calcitonin gene-related peptide (CGRP), leading to cranial vasodilation, headache, …

(Un)Weighted Assumptions: Anti-Fatness & Health, Kieran Chase, Nell Carpenter, Madysen Schreiber

OHSU-PSU School of Public Health Annual Conference

This lecture/discussion session aims to expand and add nuance to public health students’, professors’, and practitioners’ understanding of the interplay between body size and health. We will begin by naming and challenging common assumptions about the relationship between bodyweight and health outcomes. We will then argue for the consideration of weight-related stigma as a Fundamental Cause of Disease as defined by Phelan and Link, and for institutionally embedded anti-fat bias at the policy level (e.g., insurance policy, medical equipment) as a cause of population health inequity as defined in Whitehead’s Health Equity Framework. We offer these frameworks in contrast to, …

Does Sph Curricula Promote ‘Health Equity’, Reproduce Injustice, Or Both?, Jesse Yarnold

OHSU-PSU School of Public Health Annual Conference

Does SPH Curricula Promote ‘Health Equity’, Reproduce Injustice, or both?

The social justice movements of recent years (preceded by [generations of] insurmountable suffering) have facilitated a collective recognition of the systemic effects of racism and epistemic violence. Despite the ambitious and well-intentioned vision of “health equity” as defined by epidemiologic scholarship - progress is slow and injustices prevail.

Students, scholars, and researchers of ‘Public Health’ are uniquely positioned to imagine and create innovative ways of understanding and addressing the harmful inequities and injustices perpetuated by white settler colonialism. I argue that Academic institutions delivering Public Health education are uniquely positioned …

Determinants Of Modern Contraceptive Use Among Young Women In Ghana: A Mixed-Methods Study Design, Adjoa N. Manu

OHSU-PSU School of Public Health Annual Conference

Background: Only 20% of sexually active women aged 15-24 in Ghana used contraception during their last sexual intercourse. Young women are highly exposed to the risks associated with having unprotected sexual intercourse, such as unintended pregnancy and sexually transmitted infections.

Objective: To use an explanatory sequential mixed-methods design to examine the determinants of modern contraceptive use among young women in Ghana using population-based data and identify the types of contraceptive methods the population know and use.

QUAN Design: Analysis of the 2017 Ghana Maternal Health Survey data, a nationally representative cross-sectional survey.

QUAN Findings: The male …

Investing In Family Planning, Education, And Empowering Of Women And Girls To Mitigate The Impact Of Climate Change: An Exemplary Case Of Rwanda., Adjoa N. Manu

OHSU-PSU School of Public Health Annual Conference

Countries where population growth is high are often highly impacted by the climate crisis despite not being a significant contributor to historical greenhouse gas emissions. This has created a global inequality in that countries with poorly developed infrastructure are 15 times more likely to have deaths due to climate related disasters such as floods, droughts, and storms compared to wealthy countries that can better protect against similar events. While the climate crisis impacts everyone, women and girls are at a higher risk because of their unique health needs and roles in the community. The effects of climate change can be …

Housing Quality In Philadelphia, Pa: An Urban Health Equity Indicators Approach, Jennifer Piacentini

OHSU-PSU School of Public Health Annual Conference

Philadelphia is also the poorest large city in the country, and many residents live in substandard housing. Poor housing quality is associated with poor physical health outcomes as well as mental health issues (Schilling et al., 2022). Many homes in Philadelphia are of poor quality partially due to the median house age being 93 years, and the fact that 75% of homes are more than 50 years old (Jay, 2017). It has also been found that Black households are disproportionately impacted by housing quality issues. The Habitat for Humanity Philadelphia’s Home Repair programs are invaluable, and work with homeowners to …

History Of Hypertension And Urinary Incontinence Among Adults Aged 40 And Older: A Cross-Sectional Study From The National Health And Nutrition Examination Survey, Puthyda Keath, Karla Cordova Nicolas

OHSU-PSU School of Public Health Annual Conference

Introduction: Urinary incontinence (UI) impacts over 200 million individuals world-wide, though little is known about the causes of this condition. The aim of this cross-sectional study was to examine prevalence of UI and the association between a history of hypertension and UI in older adults. A secondary aim was to determine if sex modified the association between history of hypertension and UI.

Methods: This study utilized data from the U.S. National Health and Nutrition Examination Survey (NHANES) 2011-2016 cycles. We included 9,717 U.S adults (≥40 years) with complete information on history of hypertension, UI and other independent variables. Participants with …

Impact Of Industrial Disasters On The Mental Health Of Vietnamese Americans On The Gulf Coast, Vivian L. Duong

OHSU-PSU School of Public Health Annual Conference

An explosion on the Deepwater Horizon oil rig caused 200 million gallons of crude oil to spill on the Gulf Coast over a five-month span. About 16,000 miles of coastline, ecosystem and marine life along Alabama, Florida, Louisiana, Mississippi, and Texas were contaminated. This disaster and the recovery process caused social, financial, and ecological shocks, resulting in adverse psychosocial and physical health outcomes, health disparities, and socioeconomic inequality. Among the oil spill's most affected and vulnerable populations are the Vietnamese American communities that settled on the Gulf Coast after the end of the Vietnam War in 1975. The plight of …

Map The System: Presence And Impact Of Ppcps In Water, Emma Vandermeulen, Ruby Mitchell

OHSU-PSU School of Public Health Annual Conference

In a changing climate, there is growing emphasis on protecting our water sources and developing systems for conserving and reusing water. While many contaminants of concern are monitored and addressed by water treatment systems, pharmaceuticals and personal care products (PPCPs) are generally not accounted for. PPCPs in water systems have been an increasing concern as detection of these products has increased over the last few decades. Studies have been exploring the impact of antibiotics, antidepressants, contraceptives, and other anthropogenic products on our water system and how these substances interact with local ecosystems. Our main research questions are to understand what …

The Prevalence Of Osteoporosis And Low Femoral Neck Bone Density Among Never-Smoking U.S. Adults With Exposure To Secondhand Smoke: A Cross-Sectional Study Using The National Health And Nutrition Examination Survey (Nhanes), Felicia Zhou, Mikaela Haglund

OHSU-PSU School of Public Health Annual Conference

Objective

Epidemiologic studies have observed an association between exposure to secondhand smoke (SHS) and low bone mineral density (BMD) among current and past smokers. However, there is a knowledge gap in elucidating this association among never-smoking adults. The objective of this study is to examine the association between SHS exposure, measured by serum cotinine levels, and BMD for never-smoking U.S. adults.

Methods

This cross-sectional analysis included 3,224 never-smoking U.S. adults aged 50 years and older from the National Health and Nutrition Examination Survey cycles 2007-2008, 2009-2010, and 2013-2014. Serum cotinine, a biomarker for tobacco exposure, was the exposure variable while …

Qualitative Evaluation Of Medical Student Perceptions Of Chronic Disease, Mallory A. Decampos-Stairiker, Viviane Cahen, Sarah Dzubay, Saffron Evergreen, Rachel Shore

OHSU-PSU School of Public Health Annual Conference

Background:
Chronic disease is becoming increasingly common around the world. Students in different US medical training programs are exposed to varying amounts of chronic disease education and are taught unique ways of approaching chronic disease management. The purpose of this study is to investigate allopathic and naturopathic medical students’ attitudes, understandings, and perceptions of chronic diseases and their management.

Methods:
This study was conducted as a class project for UNI 504: Qualitative Methods for Health Professionals. We conducted virtual interviews during February 2023 with five allopathic and five naturopathic medical students from around the United States. Demographic information on …

Consensus Panel For Assessing Usability And Acceptability Of Mobile Health Autism Screeners, Gabriella Tangkilisan, Luis Andres Rivas Vazquez, Sarabeth Broder-Fingert, Plyce Fuchu, Benjamin Sanders, Katharine Zuckerman

OHSU-PSU School of Public Health Annual Conference

Abstract:

Background:

Parents go online to assess whether their child has symptoms of autism. Though early autism identification is important, language, cultural, and technological barriers may impede equitable access to online autism screening tools.

Objective:

To create consensus recommendations for equitable design of autism screening apps and websites using an online panel of parents, autistic self-advocates, health and educational providers, autism researchers, and online screening tool developers.

Methods:

We invited 6 parents (4 of autistic and 2 of typically-developing children), 2 autistic adults, 3 early intervention providers, 3 pediatric primary care providers, and 3 autism online screening app/website developers to …

Client-Reported Quality Of In-Facility Medication Abortion Compared With Pharmacy-Based Self-Managed Abortion In Bangladesh, Laura E. Jacobson Mph, Sarah E. Baum, Erin Pearson, Rezwana Chowdhury, Nirali M. Chakraborty, Julia Goodman, Caitlin Gerdts, Blair Darney

OHSU-PSU School of Public Health Annual Conference

Objective: We used the newly developed Abortion Care Quality (ACQ) Tool to compare client-reported quality of medication abortion care by modality (facility-based versus pharmacy-based self-managed abortion (SMA)) in Bangladesh.

Study Design: We used the abortion client ACQTool exit and 30-day follow-up surveys and bivariate statistics to compare 18 client-reported quality indicators grouped in six domains and eight abortion outcomes, by service modality. We used multivariable logistic regression to identify factors associated with selected quality indicators and outcomes (abortion affordability, information provision, and knowing what to do for an adverse event), controlling for client socio-demographic characteristics.

Results: Of 550 abortion clients, …

Telehealth Family Navigation For Early Autism Services Access: The Autism Alert Project, Mohadeseh Solgi, Avneet Sidhu, Annie Hoang, Alicia Feryn, Joseline Raja-Vora, Patricia Cavanaugh, Michelle Tae, Eric Fombonne, Katharine Zuckerman

OHSU-PSU School of Public Health Annual Conference

Background: Delays in access to educational services for autism are common and more likely among children from families of color and/or with low income. In-person family navigation accelerates autism diagnosis; however, the effectiveness of telehealth autism diagnostic navigation is unknown.

Objectives: To test preliminary feasibility and efficacy of a telehealth autism navigation program.

Method: This was a site-randomized pilot trial of autism family navigation for Oregon children in 2021-2022. The intervention used layperson family resource specialists based at Oregon’s Help Me Grow program as navigators for families of children with autism symptoms. Pediatric clinics with >30% Medicaid, located in 5 …