Medicine and Health Sciences Commons^™

Improving Effective Communication In Telephone Triage Nursing Practice: A Quality Improvement Project, Joanne Firlit

MSN Student Capstones

No abstract provided.

Pyrazole-Sulfonamide Scaffold Featuring Dual-Tail Strategy As Apoptosis Inducers In Colon Cancer, Amira Khalil, Reham M. M. El Hazek, Nashwa H. Zaher, Hagar E. S. Emam, Marwa G. Elgazzar

Pharmacy

Dual-tail strategy has been successfully utilized in the development of novel carbonic anhydrase IX (CA IX) inhibitors. Herein we adopted this approach in the design and synthesis of a series of novel pyridine sulfonamide-pyrazole hybrid scaffold mimicking dual-tail inhibitors of CA IX. A library of 15 compounds was synthesized and assessed for their potential cytotoxic effects against colorectal cancer cells. Compounds 3, and 11 induced potential cytotoxic effects against the three cancer cell lines (HCT-116, HT-29, and SW-620) with IC₅₀s’ of 45.88, 28.27, and 16.57 uM, 25.01, 8.99, and 3.27 µM, respectively. Both compounds induced cellular apoptosis …

Examining The Effects Of Outpatient Treatment For Depression Relapse Following Inpatient Psychiatric Hospitalization, Dominique Coley

Doctor of Nursing Practice Projects

This quality improvement project explores outpatient treatment's role in supporting patients with Major Depressive Disorder (MDD) after psychiatric hospitalization to reduce depression relapse risk. At an Arkansas psychiatric hospital, it was identified that re-hospitalization rates for MDD patients were increasing. The project aimed to reduce MDD re-hospitalization rates by educating the hospital's clinicians on the need for outpatient MDD treatment following hospitalization. The project leader educated the clinicians on outpatient treatment and its correlation with decreased re-hospitalization rates for MDD patients. A retrospective chart review and data analysis for hospitalized MDD patients was completed. Data collected from the charts included …

Prevention Of Surgical Site Infection: A Ten-Step Approach, Saad Tarabichi, Javad Parvizi

Rothman Institute Papers

Surgical site infection (SSI) is a common cause of morbidity and mortality in patients undergoing surgery. Similarly, periprosthetic joint infection (PJI), is a major cause of failure after total joint arthroplasty (TJA). As the annual volume of TJA procedures is projected to rise, so will the rate of subsequent SSI and PJI. Currently, prevention has been identified as the single most important strategy for combating SSI/PJI. Hence, the present article will serve as a summary of an evidence-based ten-step approach for SSI/PJI prevention that may help orthopedic surgeons with their infection prevention strategies.

Co-Exploring Meaning In Everyday Life For People In Mental Health Recovery: A Photovoice Study, Siw H. Tønnessen, Ottar Ness, Trude G. Klevan

The Qualitative Report

Research on mental health recovery points to an interdependent relationship between experiences of meaning and experiences of recovery; meaning in everyday life promotes recovery, and recovery promotes meaning in everyday life. In this study we address the following question: What do people with mental challenges find meaningful in their everyday life? To explore this question, we offered disposable cameras to people with mental health challenges and asked them to photograph whatever makes their life meaningful. As part of the collaborative procedure of the study, a competence group contributed to different stages of the research process and the visual data were …

Clustering Of Pediatric Brain Tumors In Texas, 2000-2017, Philip J Lupo, Michael E Scheurer, Abiodun O Oluyomi

Faculty, Staff and Students Publications

Risk factors for pediatric brain tumors are largely unknown. Identifying spatial clusters of these rare tumors on the basis of residential address may provide insights into childhood socio-environmental factors that increase susceptibility. From 2000-2017, the Texas Cancer Registry recorded 4305 primary brain tumors diagnosed among children (≤19 years old). We performed a spatial analysis in SaTScan to identify neighborhoods (census tracts) where the observed number of pediatric brain tumors was higher than expected. Within each census tract, the number of pediatric brain tumors was summed on the basis of residential address at diagnosis. The population estimate from the 2007-2011 American …

Using The Instrumented Sway System (Isway) To Identify And Compare Balance Domain Deficits In People With Multiple Sclerosis, Patrick G. Monaghan, Andrew S. Monaghan, Andrew Hooyman, Brett W. Fling, Jessie M. Huisinga, Daniel S. Peterson

Physical Therapy Faculty Articles and Research

Objective
To develop a multiple sclerosis (MS)-specific model of balance and examine differences between (1) MS and neurotypical controls and (2) people with MS (PwMS) with (MS-F) and without a fall history (MS-NF).

Design and Setting
A cross-sectional study was conducted at the Gait and Balance Laboratory at the University of Kansas Medical Center. Balance was measured from the instrumented sway system (ISway) assessment.

Participants
In total, 118 people with relapsing-remitting MS (MS-F=39; MS-NF=79) and 46 age-matched neurotypical controls.

Intervention
Not applicable.

Outcome Measures
A total of 22 sway measures obtained from the ISway were entered into an exploratory factor …

Guidelines For “Topics Brief” Submissions, James W. Navalta, Robert Salatto, Donald L. Hoover, Andrea Stevenson

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 4: Issue 1, Article 6, 2023. The “Topics Brief”, a novel submissions format, is introduced with authors guidelines. Within this submissions format, a category describing a target audience should be identified, such as Topics Brief for: Patients, Clinicians, Practitioners, or Students. Authors may also suggest their own category for a target audience. The title should be descriptive and allow for maximum searchability. Authorship criteria include a substantial contribution, assisting with the manuscript draft, and approval of the final version. The format is open, with a focus of presenting work in a clear and …

Introducing The “Topics Brief”: Bridging The Gap Between University And Non-Academics In A Potentially More Meaningful Way, James W. Navalta, Robert Salatto, Donald L. Hoover, Andrea Stevenson

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 4: Issue 1, Article 5, 2023. Introducing the “Topics Brief”, aiming to bridge the gap between university and non-academics. Topics Briefs should include the following: 1. Share what was done to a non-academic audience, 2. Condensed format (limited to 1-2 pages, 1 page preferred), 3. Include only the most important parts (i.e., main concepts, main results, main learned experience) to be implemented in practical application, 4. May be heavily visual (we encourage authors to be creative)

I Finally Understand How Applying The Fagan Nomogram Can Change Medical Decision-Making, David Salvatori, Do

Clinical Research in Practice: The Journal of Team Hippocrates

The author reflects on the case that changed his opinion on the efficacy of the Fagan nomogram.

A Structured Life Review Intervention To Improve Life Satisfaction In Home Health Service Patients: A Feasibility Study, Leah Graf

University Scholar Projects

Two million older adults in the U.S. suffer with depression. Adults who live with the difficulties of depression concurrently experience dissatisfaction with life. Life review is a systematic recollection of past events. Dr. Robert Butler postulated that, as the elderly and those with terminal illness approach the end of their lives, there is a resurgence of life experiences in the conscience (1963). A successful life review conducted by an active listener assists the individual to process unresolved conflicts and attain ego-integrity in the final stage of life. Home health services have become an increasingly accepted option for managing chronic illnesses …

2023-04-07_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Hypertension, Bethany Stemen

Masters Theses/Capstone Projects

Hypertension is dangerous and known as the silent killer. It can be managed with proper healthy life choices.

Understanding And Mitigating Thiaminase Activity In Silver Carp, Patricia C. Wolfe, Amber M. Tuske, Donald E. Tillitt, Fred Allen, Katie A. Edwards

Pharmacy Faculty Scholarship

A deficiency of thiamine (vitamin B1), an essential cofactor for enzymes involved in metabolic processes, can be caused by the enzyme thiaminase. Thiaminase in food stocks has been linked to morbidity and mortality due to thiamine depletion in many ecologically and economically important species. Thiaminase activity has been detected in certain bacteria, plants, and fish species, including carp. The invasive silver carp (Hypophthalmichthys molitrix) presents an enormous burden to ecosystems throughout the Mississippi River watershed. Its large biomass and nutritional content offer an attractive possibility as a food source for humans, wild animals, or pets. Additionally, harvesting this fish could …

The Length Of Hospital Stay Of Patients With Venous Thromboembolism: A Cross-Sectional Study From Jordan., Haneen Amawi, Rasha M Arabyat, Sayer Al-Azzam, Toqa Alzu'bi, Hamza Tayseer U'Wais, Alaa M Hammad, Ruba Amawi, Mohammad B. Nusair

HPD Articles

Background and Objectives: Venous thromboembolism is one of the leading causes of mortality and disability worldwide. Treatment with anticoagulation therapy is essential and requires a delicate approach to select the most appropriate option to improve patient outcomes, including the length of hospital stay (LOS). The aim of this study was to determine the LOS among patients with acute onset of VTE in several public hospitals in Jordan. Materials and Methods: In this study, we recruited hospitalized patients with a confirmed diagnosis of VTE. We reviewed the electronic medical records and charts of VTE admitted patients in addition to a detailed …

Examining Perception And Understanding Of Stroke And Its Risk Factors In A Rural Population, Mackenzie King, Gabrielle Scarpa, Mary Gardiner

Theses & Honors Papers

Stroke, also sometimes referred to as a brain attack, occurs when there is a blockage in blood supply to the brain or when a blood vessel bursts within the brain (CDC, 2022). Rural populations have a higher incidence of stroke and higher stroke mortality in the United States (Howard et al., 2017). Although there is a higher incidence rate of stroke in rural populations, researchers have also found that these populations appear to have limited knowledge on stroke and its risk factors. The current study employed a non-experimental descriptive design that explored stroke knowledge in adults residing in rural populations …

Hockey Fans In Training (Hockey Fit): Rationale, Design, And Baseline Characteristics From A Cluster Randomized Controlled Trial In Men With Overweight Or Obesity., Robert J Petrella, Dawn P Gill, Marisa Kfrerer, Brendan Riggin, Melissa Majoni, Wendy Blunt, Brooke Bliss, Narlon Cassio Boa Sorte Silva, Paul S Aspinall, Precious Adekoya, Matthew Dinunzio, Jacquelyn Marsh, Guangyong Zou, Jennifer D Irwin

Family Medicine Publications

BACKGROUND: Previous research highlights the need for effective lifestyle interventions for men. Hockey Fans in Training (Hockey FIT) was developed as a pragmatic healthy lifestyle program tailored to men with overweight or obesity. This paper overviews the rationale, program details, and design of a recently completed cluster randomized controlled trial (RCT) of Hockey FIT. Participant engagement and baseline characteristics are also described.

METHODS: The RCT evaluated the effectiveness, cost-effectiveness, and implementation of Hockey FIT. Forty-two sites in Canada and the United States were randomized to either the Hockey FIT intervention group or wait-list control group. Participants were men, aged 35-65 …

Editorial To The Ijms Special Issue On Sglt2 Inhibitors Vol. 1, Anastasios Lymperopoulos

HPD Articles

No abstract provided.

Human Cytomegalovirus (Cmv) Infection Associated With Decreased Risk Of Bronchogenic Carcinoma: Understanding How A Previous Cmv Infection Leads To An Enhanced Immune Response Against Malignancy., Selena Rashid, Amalia Ardeljan, Lexi R. Frankel, Matthew Cardeiro, Enoch Kim, Brittany M. Nagel, Kazuaki Takabe, Omar Rashid

HPD Articles

INTRODUCTION:  Cytomegalovirus (CMV) causes a long-lasting, asymptomatic infection that reportedly has both advantageous and deleterious effects on tumor progression. The purpose of this study was to evaluate the correlation between CMV infection and the incidence of bronchogenic carcinoma.

METHODS: The study was conducted using a Health Insurance Portability and Accountability Act (HIPAA) compliant national database to identify patients both with and without histories of CMV infection using International Classification of Diseases (ICD-10 and ICD-9) codes. Access to the database was granted by Holy Cross Health, Fort Lauderdale for the purpose of academic research with standard statistical methods used to analyze …

Integrating Occupational Therapy In An Inclusive Post-Secondary Education Program (Ipse) At Auburn University - Eagles, Tori Jean

OTD Capstone Projects

This capstone project focuses on incorporating occupational therapy in an inclusive post-secondary education (IPSE) program at Auburn University. The Education to Accomplish Growth in Life Experiences for Success (EAGLES) program is an IPSE program at Auburn University for young adults with intellectual disabilities. This capstone project identifies how an occupational therapist can assist with wellness, independent living, social skills, and emotional regulation skills in IPSE programs.

A Scoping Review Of Risk And Protective Factors For Negative Cannabis Use Consequences, Timothy J. Grigsby, Andrea Lopez, Larisa Albers, Christopher J. Rogers, Myriam Forster

Social and Behavioral Health Faculty Research

Objective:

Numerous reviews have examined risk and protective factors for alcohol-related negative consequences, but no equivalent review of risk and protective factors exists for cannabis-related negative consequences (CRNCs)-a gap filled by the present study. This scoping review examined survey-based research of risk and protective factors for CRNCs such as neglecting responsibilities, blacking out, or needing more cannabis.

Methods:

Three databases (PubMed, PsycINFO, and Google Scholar) were searched for peer-reviewed manuscripts published between January 1, 1990, and December 31, 2021. A qualitative synthesis was performed using the matrix method and the results were organized using the socioecological model as a framework. …

Adolescent Use And Co-Use Of Tobacco And Cannabis In California: The Roles Of Local Policy And Density Of Tobacco, Vape, And Cannabis Retailers Around Schools, Georgiana Bostean, Anton M. Palma, Alison A. Padon, Erik Linstead, Joni Ricks-Oddie, Jason A. Douglas, Jennifer B. Unger

Sociology Faculty Articles and Research

Adolescent tobacco use (particularly vaping) and co-use of cannabis and tobacco have increased, leading some jurisdictions to implement policies intended to reduce youth access to these products; however, their impacts remain unclear. We examine associations between local policy, density of tobacco, vape, and cannabis retailers around schools, and adolescent use and co-use of tobacco/vape and cannabis.

We combined 2018 statewide California (US) data on: (a) jurisdiction-level policies related to tobacco and cannabis retail environments, (b) jurisdiction-level sociodemographic composition, (c) retailer locations (tobacco, vape, and cannabis shops), and (d) survey data on 534,176 middle and high school students (California Healthy Kids …

Intensive Care Unit Mortality And Length Of Stay Among Critically Ill Patients With Sepsis Treated With Corticosteroids: A Retrospective Cohort Study, Eric E. Chinaeke, Ismaeel Yunusa Ph.D., Bryan L. Love Pharm. D., Joseph Magagnoli, Claiborne E. Reeder

Faculty Publications

Objectives: Sepsis is a major cause of morbidity and mortality in critically ill patients worldwide, and corticosteroids are commonly used to treat it. However, the evidence supporting the use of corticosteroids in sepsis patients admitted to the intensive care unit (ICU) is of low certainty, with conflicting results reported in previous studies. Thus, we aimed to investigate the potential association between corticosteroid treatment and various outcomes, including 30-day ICU mortality, ICU length of stay (LOS), mechanical ventilation use, new onset of infection, and hyperglycemia in patients diagnosed with sepsis and admitted to the ICU.

Materials and Methods: We conducted …

Automatic Detection Of Circulating Tumor Cells And Cancer Associated Fibroblasts Using Deep Learning, Cheng Shen, Siddarth Rawal, Rebecca Brown, Haowen Zhou, Ashutosh Agarwal, Mark A Watson, Richard J Cote, Changhuei Yang

2020-Current year OA Pubs

Circulating tumor cells (CTCs) and cancer-associated fibroblasts (CAFs) from whole blood are emerging as important biomarkers that potentially aid in cancer diagnosis and prognosis. The microfilter technology provides an efficient capture platform for them but is confounded by two challenges. First, uneven microfilter surfaces makes it hard for commercial scanners to obtain images with all cells in-focus. Second, current analysis is labor-intensive with long turnaround time and user-to-user variability. Here we addressed the first challenge through developing a customized imaging system and data pre-processing algorithms. Utilizing cultured cancer and CAF cells captured by microfilters, we showed that images from our …

Cold Atmospheric Pressure Plasma-Antibiotic Synergy In Pseudomonas Aeruginosa Biofilms Is Mediated Via Oxidative Stress Response, Jordanne-Amee Maybin, Thomas P. Thompson, Padrig B. Flynn, Timofey Skvortsov, Noreen J. Hickok, Theresa A. Freeman, Brendan F. Gilmore

Department of Orthopaedic Surgery Faculty Papers

Cold atmospheric-pressure plasma (CAP) has emerged as a potential alternative or adjuvant to conventional antibiotics for the treatment of bacterial infections, including those caused by antibiotic-resistant pathogens. The potential of sub-lethal CAP exposures to synergise conventional antimicrobials for the eradication of Pseudomonas aeruginosa biofilms is investigated in this study. The efficacy of antimicrobials following or in the absence of sub-lethal CAP pre-treatment in P. aeruginosa biofilms was assessed. CAP pre-treatment resulted in an increase in both planktonic and biofilm antimicrobial sensitivity for all three strains tested (PAO1, PA14, and PA10548), with both minimum inhibitory concentrations (MICs) and minimum biofilm eradication …

Healthcare Service Use, Help-Seeking Behaviors, And Health And Wellbeing In Attenuated Psychosis, Jasmine Ranjbari-Sisan, William D. Spaulding, Tierney K. Lorenz

Honors Program: Senior Projects (Public)

Persons with serious mental illness (SMI) receive poorer-than-standard healthcare, contributing to a 20-year reduction in the average life expectancy of persons with SMI. While extant literature describes the health disparities experienced by persons with SMI, little research examines the relationship between attenuated psychotic symptoms, healthcare service use, and help-seeking behaviors that may contribute to the disparities in this vulnerable population. This study explores the relationships between attenuated psychotic symptoms, physical health symptoms and related distress, healthcare service use, and help-seeking intentions to better understand health disparities in vulnerable and marginalized populations, such as individuals with SMI. Only a portion of …

Enhancing Otd Clinical Studies Course Curriculum, Katherine J. Rauch

OTD Capstone Projects

This capstone project aimed to build upon the foundation of the Belmont School of Occupational Therapy clinical studies course curriculum. Project goals included conducting surveys of current students regarding their opinions of the courses for preparing fieldwork readiness skills, creating and piloting learning activities, and informing current faculty about best practices for teaching clinical reasoning skills. This project culminated with the production of an educational handout summarizing current literature regarding teaching professional reasoning skills, multiple learning activities implemented in lectures, and data synthesis of surveys conducted.

Primary Bilateral Macronodular Adrenocortical Hyperplasia (Pbmah) Patient With Armc5 Mutations., Peng Tang, Jun Zhang, Song Peng, Xuzhi Yan, Yapeng Wang, Shuo Wang, Yao Zhang, Gaolei Liu, Jing Xu, Yiqiang Huang, Dianzheng Zhang, Qiuli Liu, Jun Jiang, Weihua Lan

PCOM Scholarly Works

BACKGROUND: Primary bilateral macronodular adrenocortical hyperplasia (PBMAH) is a highly heterogeneous disease with divergent manifestations ranging from asymptomatic subclinical Cushing syndrome (CS) to overt Cushing syndrome with severe complications. ARMC5 mutations occur in 20 to 55% PBMAH patients usually with more severe phenotypes. Different ARMC5 mutations might be associated with diverse phenotypes of PBMAH.

CASE PRESENTATION: A 39-year-old man was admitted to our hospital with progressive weight gain and severe hypertension. He presented typical CS and its classical metabolic and bone complications like hypertension and osteoporosis. The laboratory results showed high levels of cortisol and low levels of ACTH. Low- …

Alcohol-Associated Liver Disease Mortality Rates By Race Before And During The Covid-19 Pandemic In The Us, Jagpreet Chhatwal

Faculty, Staff and Students Publications

This cross-sectional study examines the national- and state-level age-adjusted mortality rates for alcohol-associated liver disease in 4 racial groups, with a focus on the American Indian or Alaska Native population.

The Effects Of A Blood–Brain Barrier Penetrating Erythropoietin In A Mouse Model Of Tauopathy, Joshua Yang, Weijun Ou, Nataraj Jagadeesan, Juste Simanauskaite, Jiahong Sun, Demi M. Castellanos, David H. Cribbs, Rachita K. Sumbria

Pharmacy Faculty Articles and Research

Erythropoietin (EPO), a hematopoietic neurotrophin, is a potential therapeutic for Alzheimer’s disease (AD) but has limited blood–brain barrier (BBB) permeability. EPO fused to a chimeric transferrin receptor monoclonal antibody (cTfRMAb) enters the brain via TfR-mediated transcytosis across the BBB. We previously showed that cTfRMAb-EPO is protective in a mouse model of amyloidosis, but its effects on tauopathy are not known. Given that amyloid and tau pathology are characteristics of AD, the effects of cTfRMAb-EPO were studied in a tauopathy mouse model (PS19). Six-month-old PS19 mice were injected intraperitoneally with either saline (PS19-Saline; n = 9) or cTfRMAb-EPO (PS19-cTfRMAb-EPO, 10 mg/kg; …