Medicine and Health Sciences Commons^™

Effects On Pregnancy Outcome In Female Mice Exposed To Cyclophosphamide At Prepubertal Age, Sujith Raj Salian, Shubhashree Uppangala, Guruprasad Kalthur, Satish Kumar Adiga

Manipal Research Colloquium - 2023

Manipal Research Colloquium- 2023 aims to bring students, scholars, and scientists to this forum where discussion on a diverse range of topics from various streams (Health Sciences, Technical Sciences, Basic & Applied Sciences, Humanities & Social Sciences, and Management Sciences) will be taking place.

Identification And Characterization Of The Role Of A Novel Inhibitor Of Eif4e-4ebp1 Protein Complex, Which Is Involved In Protein Translation Regulation, Saradindu Banerjee, Krishnaprasad B, Ranita Ghosh Dastidar, Usha Y. Nayak, Yogendra Nayak, Somasish Ghosh Dastidar

Manipal Research Colloquium - 2023

Manipal Research Colloquium- 2023 aims to bring students, scholars, and scientists to this forum where discussion on a diverse range of topics from various streams (Health Sciences, Technical Sciences, Basic & Applied Sciences, Humanities & Social Sciences, and Management Sciences) will be taking place.

Mrcms013 Chatgpt In Research – A Grounded Theory Approach, Kartikeya Bolar

Manipal Research Colloquium - 2023

Manipal Research Colloquium- 2023 aims to bring students, scholars, and scientists to this forum where discussion on a diverse range of topics from various streams (Health Sciences, Technical Sciences, Basic & Applied Sciences, Humanities & Social Sciences, and Management Sciences) will be taking place.

A Cross-Sectional Study On Influence Of Electronic Word Of Mouth On Restaurant Selection Among Diners., Paritosh Dabral, Ajith Kumar, Samiksha Hawa, Senthil Kumaran

Manipal Research Colloquium - 2023

Manipal Research Colloquium- 2023 aims to bring students, scholars, and scientists to this forum where discussion on a diverse range of topics from various streams (Health Sciences, Technical Sciences, Basic & Applied Sciences, Humanities & Social Sciences, and Management Sciences) will be taking place.

Antibacterial Properties Of Amniotic Membrane: A Review, Kiran F. Fatima, Likhith K, Goutam Thakur, Bhisham N. Singh

Manipal Research Colloquium - 2023

Manipal Research Colloquium- 2023 aims to bring students, scholars, and scientists to this forum where discussion on a diverse range of topics from various streams (Health Sciences, Technical Sciences, Basic & Applied Sciences, Humanities & Social Sciences, and Management Sciences) will be taking place.

In-Vitro Antioxidant, Cytotoxic And Anti-Migratory Analysis Of Petroleum Ether Fraction Of Crude Seed Extract Of Bunium Bulbocastanum On Pc-3 Cell Lines, Vijetha Shenoy Belle, Siri Chandrashekar, Vedant Kamal M, Sreedhara Ranganath Pai

Manipal Research Colloquium - 2023

Manipal Research Colloquium- 2023 aims to bring students, scholars, and scientists to this forum where discussion on a diverse range of topics from various streams (Health Sciences, Technical Sciences, Basic & Applied Sciences, Humanities & Social Sciences, and Management Sciences) will be taking place.

Mimosa Pudica Exhibits In Vivo Female Antifertility Activity By Affecting Various Phases Of Pregnancy, Keerthi Priya, M Manjunath Setty, U V. Babu, Mausami Ganguly, K Sreedhara R Pai

Manipal Research Colloquium - 2023

Manipal Research Colloquium- 2023 aims to bring students, scholars, and scientists to this forum where discussion on a diverse range of topics from various streams (Health Sciences, Technical Sciences, Basic & Applied Sciences, Humanities & Social Sciences, and Management Sciences) will be taking place.

Theranostic And Precision Medicine: An Integrated And Futuristic Approach To Tackle Cancer, Mugdha Kulkarni, Manasa C. M, Krishna Kishor H G

Manipal Research Colloquium - 2023

Manipal Research Colloquium- 2023 aims to bring students, scholars, and scientists to this forum where discussion on a diverse range of topics from various streams (Health Sciences, Technical Sciences, Basic & Applied Sciences, Humanities & Social Sciences, and Management Sciences) will be taking place.

Molecular Mechanisms Of Immune Escape Of Sars-Cov-2 Omicron Variants: A Computational Biology Study, Disha A, Nikhil Pathak, Nirmal Mazumdar

Manipal Research Colloquium - 2023

Manipal Research Colloquium- 2023 aims to bring students, scholars, and scientists to this forum where discussion on a diverse range of topics from various streams (Health Sciences, Technical Sciences, Basic & Applied Sciences, Humanities & Social Sciences, and Management Sciences) will be taking place.

Natural Sugar Substitutes In Sugar Free Ice Cream, Avery Lawes, Cheyenne Davies, Catherine Breitweiser

Student Research Symposium

Artificial sweeteners have become increasingly more popular over the years as good sucrose substitutes but how do these sweeteners affect ice cream? As most of the population is struggling with obesity and diabetes, is there a way to make an ice cream that is both high in nutritional content and tastes good? The purpose of this experiment is to determine the effect on volume, texture, flavor, aftertaste, and meltability when substituting naturally occurring sugar substitutes for liquid Stevia in vanilla ice cream. This was done by mixing 4 different batches of ice cream using different naturally occurring sweeteners (honey, agave, …

Observing The Variations In Peanut Butter Cookies - Replacing All-Purpose Flour To Maximize Protein Intake, Mia Knight, Joy Bruneel, Jessica Mills, Ashley Sorensen

Student Research Symposium

Protein plays a vital role in every human’s life. This macronutrient is essential in the diet for cell formation and repair. Protein powder, a nutritional supplement, is used to help build muscle, repair tissue, and make enzymes and hormones. Protein powder has also been found to help people lose weight and tone their muscles. Since some people have trouble getting enough daily protein, specifically athletes and elderly individuals, this study aims to research and learn the effects of substituting almond flour, whey protein powder, and soy protein powder in place of all-purpose flour to achieve a quality-tasting, protein-packed peanut butter …

Effect Of Ph On Yeast Activation In Leavened Bread, Halle Larson, Gracee Allen, Allison Jones, Hanna Jensen

Student Research Symposium

Bread is a staple in the diet of many different populations around the world, and yeast is an important component of bread making. The amount of yeast fermentation that is achieved has a large impact on the outcome of the bread, most particularly on the final volume and density. The purpose of our research was to determine if pH had an effect on the fermentation process of bakers yeast in bread. We decided to test this by altering the pH of the activation solution used in a basic bread recipe to various pH levels, including basic (9), neutral (7), acidic …

The Effect Of Whey Protein On Gluten-Free Rolls, Maeci Armstrong, Lindsay Jarman, Sara Marshall

Student Research Symposium

Growing numbers of people developing celiac disease and gluten intolerances have increased the demand for gluten-free products in the United States. 1 Many gluten-free breads are low in protein and lack the desired texture, volume, and flavor that can be found in most standard wheat bread products. Whey protein has been shown to increase the protein content in bread and mimic gluten in creating a protein network within the dough to produce the desired texture. 1 This experiment aims to determine the effect on texture, moisture, flavor, volume, cell structure, and acceptability when whey protein isolate is added in 4 …

2023 Reday Awards Recipients

Bryant REDay (Research and Engagement Day)

List of award winners for 2023 REDay.

Program

Bryant REDay (Research and Engagement Day)

11th Annual Research and Engagement Day Program with descriptions and schedule of events.

Prevention And Delayed Progression Of Diabetic Nephropathy, Russell Scott

SIU Journal of Medical Science Scholarly Works

ABSTRACT

Aim/Purpose: The purpose of this clinical research article is to determine if there are comparable alternatives to industry-standard or gold-standard renin-angiotensin system (RAS) blockade for diabetic nephropathy (DN) prevention or delayed progression when RAS blocking agents are contraindicated or not tolerated.

Method: A PubMed literature search was conducted utilizing search terms including diabetic nephropathy unaccompanied and in combination with sodium-glucose co-transporter 2 (SGLT2) inhibitor, glucagon-like peptide 1 (GLP1) receptor agonist, calcium channel blocker (CCB), mineralocorticoid receptor antagonist (MRA) and RAS blockade or blocker. PubMed search filters included full-text articles and article submissions no greater than 5 years from approximately …

2023-04-12_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Medical School Watercooler Newsletter - April 12, 2023, Lindsey Lyle

Watercooler Newsletter

This is the April 12, 2023 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• USA health NICU selected by NIH to study effect of antibiotics on preterm infants
• Surgeons discover innovative approach to treating burn survivors
• Wellness Council hosts crawfish boil

B-Cell Monoclonal Antibodies For Management Of Relapse Remitting Multiple Sclerosis: A Cost Effectiveness Analysis, Sarah Glover

Pharmaceutical Sciences ETDs

Multiple sclerosis (MS) is a neurodegenerative disease in which the central nervous system’s myelin sheath is degraded by auto-immune cells. Relapse remitting multiple sclerosis (RRMS) is the most common MS phenotype, accounting for ~85% of new diagnoses. Disease modifying therapies (DMTs) are used in RRMS to reduce the frequency of relapses and prevent disability progression. The present study performed a cost effectiveness analysis of three B-cell depleting monoclonal antibody DMTs: ocrelizumab, ofatumumab and rituximab, in comparison to commonly utilized interferon beta-1a (IFN-B1a). A Markov model was created to determine the impact of selected DMTs on the number of …

2023-04-12_Michiganoverview_Covidvaccinestats, Michigan Department Of Health & Human Services

Michigan COVID-19 Vaccine Data

The COVID Vaccine Dashboard page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/resources/covid-19-vaccine/covid-19-dashboard.

First-dose tracker above is for entire Michigan Population. Coverage maps below are for age 5+.

Previously reported numbers of administered vaccine doses may change as new data are received. A possible lag in reporting vaccine doses will result in increases in numbers previously reported.

This report is created by the Michigan Department of Health and Human Services Division of Immunization from data reported to the Michigan Care Improvement Registry (MCIR).

The dashboard contained the tabs Primary Series Doses Administered, Primary Series Doses by Vaccine, …

Guidelines For Performing Caudal Blocks In Pediatric Sub-Umbilical Surgeries, Rachael Allen

Doctor of Nursing Practice Scholarly Projects

Adequate pain control in pediatric patients undergoing sub-umbilical surgeries is critical because of the increased need for opioids and heart rate (HR) fluctuations that occur in the postoperative period. The traditional approach of providing anesthesia in sub-umbilical surgeries is general anesthesia(GA); however, this approach does provide prolonged pain relief. This project aims to establish evidence-based guidelines for implementing caudal blocks (CA) with GA in pediatric sub-umbilical surgeries. By implementing CA with GA, patients experience less pain, leading to a reduction of opioids and HR fluctuations in the postoperative period. The project follows the John Hopkins Evidence-Based Practice (JHEBP) model, a …

Giant Mesenchymal Hepatic Hamartomas With Adrenal Involvement Precipitating Respiratory Failure: A Myxomatous Mystery In A Three-Month-Old., Ali Yasback, Abid Ulhaque, Tushar Chandra

HPD Articles

The combination of placental mesenchymal dysplasia and hepatic mesenchymal hamartomas is an extremely rare finding. We present the case of a three-month-old female born at 35 weeks gestation with a history of placental mesenchymal dysplasia who presented with non-bilious, non-bloody emesis, and episodes of respiratory distress due to multiple enlarging abdominal cystic lesions. The patient's presentation was unique due to both liver and adrenal solid and cystic lesions. After extensive imaging and multiple biopsies, expert interpretation of biopsy tissue revealed hepatic mesenchymal hamartoma within the liver and the adrenal gland. To our knowledge, this is one of the few documented …

Lessons From Canada’S Notice Of Compliance With Conditions Policy For The Life-Cycle Regulation Of Drugs, Melanie Mcphail, Howard Zhang, Zohra Bhimani, Tania M. Bubela

Office of the Provost

Innovative health technologies are not well regulated under current pathways, leading regulators to adopt contextual, life-cycle regulatory models, which authorize drugs based on earlier clinical evidence subject to the conduct of post-market trials that confirm clinical benefit and safety. In this paper, we evaluate all drugs authorized in Canada under the Notice of Compliance with conditions (NOC/c) policy from 1998 to 2021 to analyze its function, identify challenges and areas for improvement, and make recommendations to inform Health Canada's regulatory reforms. We analyzed a sample of 148 drugs authorized between 1998 and 2021, including characteristics about the pre- and post-market …

The Impact Of County Level Characteristics On Type 2 Diabetes Related Ed Utilization, Jessica Wilson

MUSC Theses and Dissertations

Approximately 90-95% of the more than 37 million American adults who are living with diabetes have type 2 diabetes. Additionally, those living in rural areas face poor health outcomes related to chronic diseases such as diabetes. The impact of factors related to social determinants of health such as the role of rurality and social vulnerability were described by examining county diabetes related Emergency Department (ED) visit rates for adults aged 18-25 living in North Carolina. No difference in county level diabetes related ED visits were observed between rural counties vs. nonrural counties in the state. However, patterns did emerge in …

Developing A Pediatric Weight Management Program In Primary Care, Alyssa Bosse

Masters Theses/Capstone Projects

The practicum was completed at Central Ohio Primary Care Physicians (COPC), a large group of physician owned primary care practices. COPC would like to start a program for pediatric weight management utilizing their three pediatric Registered Dietitian Nutritionists (RDNs). The first step was collecting data to see any improvements that are needed from the current nutrition program. The second step was reviewing the literature on pediatric weight management to ensure the new program is evidenced-based. All steps were evaluated by COPC leadership and collaborated with internal company resources.

Perceptions Of Preparedness Among New Graduate Nurses: Traditional Curriculum Versus Concept-Based Curriculum, Ashley A. Wheeler, Steven Busby, David Phillippi, Tammy Legge

DNP Projects

Concept-based curriculum (CBC) is a newer trend in nursing education curriculum aimed at preparing new graduates to enter the workforce as generalist nurses better suited to care for a more medically complex population. Using CBC, students are introduced to concepts in order to build conceptual understandings as they engage in knowledge and skill learning, as opposed to a traditional nursing curriculum that is taught in sections grouped by patient population and medical complexity. At a nursing school housed within a private university in the southeast, the traditional nursing curriculum was replaced with CBC in 2016. To better understand the preparedness …

Contrast-Enhanced Cardiac Magnetic Resonance Imaging With A Manganese-Based Alternative To Gadolinium For Tissue Characterization Of Acute Myocardial Infarction, Benjamin P. Bonner, Salva R. Yurista, Jaume Coll-Font, Shi Chen, Robert A. Eder, Anna N. Foster, Khoi D. Nguyen, Peter Caravan, Eric M. Gale, Christopher Nguyen

School of Medicine Faculty Publications

BACKGROUND: Late gadolinium enhancement cardiac magnetic resonance imaging is an effective and reproducible method for characterizing myocardial infarction. However, gadolinium-based contrast agents are contraindicated in patients with acute and chronic renal insufficiency. In addition, several recent studies have noted tissue deposition of free gadolinium in patients who have undergone serial contrast-enhanced magnetic resonance imaging. There is a clinical need for alternative forms of magnetic resonance imaging contrast agents that are acceptable in the setting of renal insufficiency. METHODS AND RESULTS: Three days after 80 minutes of ischemia/reperfusion of the left anterior descending coronary artery, cardiac magnetic resonance imaging was performed …

A Quality Improvement Initiative To Improve Follow-Up Time And Reduce Readmissions And Emergency Department Utilization For Oncology Patients, Delaney Serfling

MUSC Theses and Dissertations

Hospitals across the nation are facing extreme challenges with overcrowding. Unplanned readmissions and emergency department use are two significant contributors to this urgent issue. Historically, oncology patients are high utilizers of emergency department services, and have elevated numbers of unplanned readmissions. This is especially true of gastrointestinal medical oncology patients. In an effort to move the needle in the right direction, an operational quality improvement initiative to decrease emergency department utilization and unplanned readmissions was conducted. This pilot project took place over a three-month period, and consisted of protecting time for advanced practice providers (APPs) and updating inefficient workflows. The …

Staff Education To Increase Confidence In Caring For Lgbtqi Cancer Patients: A Quality Improvement Initiative, Clara C. Beaver

Masters Projects

This project was to provide education to promote a welcoming environment, increase staff knowledge, and confidence in caring for LGBTQI cancer patients. Methods: An educational session was provided to increase staff competence and knowledge about LGBTQI cancer patient uniqueness. A pre- and post-test was administered to measure staff knowledge, comfort in discussing with coworkers, and confidence in caring for LGBTQI patients. Results: After the session, there was a 42% increase in staff responses to the importance of knowing about a patient’s sexual orientation when providing care, 58% increase in knowledge about cancer issues related to LGBTQI population, and 39% increase …

Hiv-Differentiated Metabolite N-Acetyl-L-Alanine Dysregulates Human Natural Killer Cell Responses To Mycobacterium Tuberculosis Infection, Baojun Yang, Tanmoy Mukherjee, Rajesh Radhakrishnan, Padmaja Paidipally, Danish Ansari, Sahana John, Ramakrishna Vankayalapati, Deepak Tripathi, Guohua Yi

School of Medicine Faculty Publications and Presentations

Mycobacterium tuberculosis (Mtb) has latently infected over two billion people worldwide (LTBI) and caused ~1.6 million deaths in 2021. Human immunodeficiency virus (HIV) co-infection with Mtb will affect the Mtb progression and increase the risk of developing active tuberculosis by 10–20 times compared with HIV- LTBI+ patients. It is crucial to understand how HIV can dysregulate immune responses in LTBI+ individuals. Plasma samples collected from healthy and HIV-infected individuals were investigated using liquid chromatography–mass spectrometry (LC-MS), and the metabolic data were analyzed using the online platform Metabo-Analyst. ELISA, surface and intracellular staining, flow cytometry, and quantitative reverse-transcription PCR (qRT-PCR) were …