Medicine and Health Sciences Commons^™

Safe Practices For Preventing Covid-19 Among School-Aged Children, Meleena Reyelle Banda-Garcia

Nursing | Senior Theses

Communicable diseases and infections are common health problems among children. Among the most impactful communicable diseases present today is COVID-19, a disease caused by a virus named SARS-CoV-2, which has forced many school closures due to rapid transmission. Despite children not being the main driving factor of the spread of the disease, severe complications underlying COVID-19 incidence have resulted in increased hospitalization among school-age children.The initial global response to the spread of COVID-19 included the closure of school systems; however as the disease continues to be effectively managed, communities are starting to re-open schools partially or entirely nationwide. Although pharmaceutical …

Acute Kidney Injury In Hospitalized Children With Sickle Cell Anemia, Anthony Batte, Sahit Menon, John Ssenkusu, Sarah Kiguli, Robert Kalyesubula, Joseph Lubega, Edrisa Ibrahim Mutebi, Robert Opoka, Chandy John, Michelle Starr

Paediatrics and Child Health, East Africa

Background: Children with sickle cell anemia (SCA) are at increased risk of acute kidney injury (AKI) that may lead to death or chronic kidney disease. This study evaluated AKI prevalence and risk factors in children with SCA hospitalized with a vaso-occlusive crisis (VOC) in a low-resource setting. Further, we evaluated whether modifcations to the Kidney Disease: Improving Global Outcomes (KDIGO) defnition would infuence clinical outcomes of AKI in children with SCA hospitalized with a VOC.

Methods: We prospectively enrolled 185 children from 2 – 18 years of age with SCA (Hemoglobin SS) hospitalized with a VOC at a tertiary hospital …

Blackwater Fever And Acute Kidney Injury In Children Hospitalized With An Acute Febrile Illness: Pathophysiology And Prognostic Significance, Andrea Conroy, Michael Hawkes, Aleksandra Leligdowicz, Ivan Mufumba, Michelle Starr, Kathleen Zhong, Sophie Namasopo, Robert Opoka, Chandy John, Kevin C. Kain

Paediatrics and Child Health, East Africa

Background: Acute kidney injury (AKI) and blackwater fever (BWF) are related but distinct renal complications of acute febrile illness in East Africa. The pathogenesis and prognostic signifcance of BWF and AKI are not well understood.

Methods: A prospective observational cohort study was conducted to evaluate the association between BWF and AKI in children hospitalized with an acute febrile illness. Secondary objectives were to examine the association of AKI and BWF with (i) host response biomarkers and (ii) mortality. AKI was defned using the Kidney Disease: Improving Global Outcomes criteria and BWF was based on parental report of tea-colored urine. Host …

Improving The Perioperative Experience Of Patients And Families In A Pediatric Setting, Anjanette Pong

Student Scholarly Projects

Practice Problem: The experience of surgery for pediatric patients and their families can be dependent on multiple factors including adequate preparation, English language proficiency and realistic expectations. Anxiety can contribute to a negative experience that may result in poor outcomes and a damaging reflection of the healthcare team and organization.

PICOT: The PICOT question that guided this project was: In preoperative pediatric patients and their families, how do therapeutic communication style and the provision of information about the perioperative experience affect their healthcare experience over eight weeks?

Evidence: A multi-modal approach to providing tailored preoperative education for the child and …

Tip-Over Injuries Among Children: Data From An Urban Emergency Department Of Karachi, Pakistan, Rubaba Naeem, Asrar Ali, Ahmed Raheem Buksh, Ayesha Quddusi, Uzma Rahim Khan

Department of Emergency Medicine

Introduction: Most unintentional injuries among children occur in the home environment. Tip-overs, defined as incidents where heavy objects fall on children due to some type of interaction, are one of the reasons for injuries inside the home. This study aims to determine injury patterns and outcomes for child injuries resulting from tip-overs in the home environment as reported in the emergency department.
Methods: We performed a retrospective chart review of pediatric (under 18 years) tip-overs injuries occurred in years 2010 to 2015 at the Aga Khan University Hospital. Furthermore, parents of injured children participated in phone interviews to provide information …

Speech-Language Pathologists’ Treatment Goals For Preschool Language Disorders: An Icf Analysis, Elaine Yl Kwok, Peter Rosenbaum, Barbara Jane Cunningham

PRECISe Preschool Speech and Language Publications

Purpose: The World Health Organization's International Classification of Functioning, Disability and Health (ICF) provides a comprehensive framework to conceptualise clinical services. This study explored how speech-language pathologists (SLPs) conceptualised therapy goals for preschoolers with language difficulties and disorders within the ICF framework.Method: An online survey was distributed to SLPs practising in a publicly funded Preschool Speech and Language program in Ontario, Canada. SLPs rated their familiarity with the ICF framework, and then reported all therapy goals for one child with language difficulty/disorder on their caseload. For each reported goal, SLPs indicated the ICF component(s) they felt the …

The Role Of Metformin In Treatment Of Weight Gain Associated With Atypical Antipsychotic Treatment In Children And Adolescents: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Zeeshan Mansuri, Ramkrishna Makani, Chintan Trivedi, Mahwish Adnan, Ramu Vadukapuram, John Rafael, Ashutosh Lodhi, Abhishek Reddy

School of Medicine Publications and Presentations

Introduction: Second-generation antipsychotics are associated with significant weight gain. The aim of this systematic review and meta-analysis was to determine the efficacy and safety of metformin for the treatment of weight gain in children and young adults treated with second-generation antipsychotics.

Methods: We followed PRISMA guidelines to evaluated studies published before March 2020 in Medline, Google Scholar, PubMed, Cochrane library database, annual scientific sessions of the American Psychiatric Association, American Academy of Child and Adolescent, Psychiatry, and American Society of Clinical Psychopharmacology. Studies included compared metformin with the placebo for management of weight gain in children and adolescents taking atypical …

Functional Links Between Thermoregulation And Sleep In Children With Neurodevelopmental And Chronic Health Conditions, Susan M. Mccabe, Chris R. Abbiss, Jean Pierre Libert, Véronique Bach

Research outputs 2022 to 2026

The bi-directional relationship between sleep and wake is recognized as important for all children. It is particularly consequential for children who have neurodevelopmental disorders (NDDs) or health conditions which challenge their sleep and biological rhythms, and their ability to maintain rhythms of participation in everyday activities. There are many studies which report the diverse reasons for disruption to sleep in these populations. Predominantly, there is focus on respiratory, pharmaceutical, and behavioral approaches to management. There is, however, little exploration and explanation of the important effects of body thermoregulation on children’s sleep-wake patterns, and associated behaviors. Circadian patterns of sleep-wake are …

Mothers’ Satisfaction With Distraction As A Postoperative Pain Management Intervention For Their Child: An Interventional Study, Edlin Glane Mathias, Mamatha Shivananda Pai, Vijay Kumar, Vasudeva Guddattu, Ann-Cathrine Bramhagen

Journal of Perioperative Nursing

Aim: This study aimed to investigate mothers’ levels of satisfaction with distraction as a post-operative pain management intervention for their child.

Background: Although the number of studies on paediatric pain management has increased over time, research into non-pharmacological post-operative pain management remains inadequate, indicating that more research is required.

Design: A posttest-only control group design was adopted to measure mothers’ levels of satisfaction with distraction as a non-pharmacological post-operative pain management intervention for their child.

Methods: The study included 160 mothers and their children undergoing elective surgery in a paediatric surgical unit. Mothers and children were randomly allocated to intervention …

The Enigma Of Primary Hypertension In Childhood, Bonita Falkner

Department of Medicine Faculty Papers

Beginning in the 1970s, hypertension in children and adolescents has been defined as systolic and/or diastolic blood pressure (BP) that is equal to or greater than the 95th percentile of the normal BP distribution in healthy children. The definition of hypertension in adults is based on longitudinal data that links a BP level with an increased risk for subsequent adverse outcomes related to hypertension including heart failure, kidney failure, stroke, or death. The statistical definition of hypertension continues to be used in childhood because there have been no data that link a BP level in childhood with a heightened risk …

The Childhood Acute Illness And Nutrition (Chain) Network Nested Case-Cohort Study Protocol: A Multi-Omics Approach To Understanding Mortality Among Children In Sub-Saharan Africa And South Asia, James M. Njunge, Kirkby Tickell, Abdoulaye Hama Diallo, Abu Sadat Mohammad Sayeem Bin Shahi, Md Amran Gazi, Ali Faisal Saleem, Zaubina Kazi, Syed Ali, Caroline Tigoi, Ezekiel Mupere

Department of Paediatrics and Child Health

Introduction: Many acutely ill children in low- and middle-income settings have a high risk of mortality both during and after hospitalisation despite guideline-based care. Understanding the biological mechanisms underpinning mortality may suggest optimal pathways to target for interventions to further reduce mortality. The Childhood Acute Illness and Nutrition (CHAIN) Network ( www.chainnnetwork.org) Nested Case-Cohort Study (CNCC) aims to investigate biological mechanisms leading to inpatient and post-discharge mortality through an integrated multi-omic approach.
Methods and analysis; The CNCC comprises a subset of participants from the CHAIN cohort (1278/3101 hospitalised participants, including 350 children who died and 658 survivors, and …

Prevalence Of Hiv And Associated Risk Factors Among Street-Connected Children In Mwanza City, Said Nyumayo, Eveline Konje, Benson Kidenya, Anthony Kapesa, Marko Hingi, Nyagwegwe Wango, Joshua Ngimbwa, Violeth Alphonce, Namanya Basinda

Institute for Educational Development, East Africa

While on the street, HIV infection among street-connected children is a challenging issue due to the nature of transmission, distribution, and prevention. Lack of proper care and protection, insufficient knowledge of the danger of acquiring HIV, and insufficient or absence of health facilities serving street-connected children have left this vulnerable group engaging in high-risk behaviors exposing them to acquiring HIV. This cross-sectional study aimed at estimating the prevalence of HIV infection and its associated risk factors among street-connected children aged between 10 to17 years in Mwanza City. The study was granted ethical clearance all permissions and restrictions to work with …

Everyday Life With Childhood Functional Constipation: A Qualitative Phenomenological Study Of Parents' Experiences, Gunilla Flankegård, Evalotte Mörelius, Patrik Rytterström

Research outputs 2022 to 2026

Childhood functional constipation (FC) is a worldwide problem with treatment regiments affecting everyday life. Aim: To explore parents´ experiences of living with a child with FC and its impact on everyday family life. Method: A qualitative phenomenological interview study using a reflective lifeworld research approach. Interviews with 15 parents of otherwise healthy children aged 1–14 years affected by FC. Findings: Shame is the driving force making parents put everyday life on hold. The quest for control, self-imposed loneliness, guilt, inadequacy, and frustrating battles become essential parts of everyday life to protect it from FC-related shame. Conclusion: FC has as great …

The Effect Of Linguistic Context And Explicit Contrast On The Fast Mapping Of Verbs, Samantha L. Scripture

Doctoral Dissertations

In typical language acquisition, word learning is an induction problem. When word learners hear an unfamiliar word, they make assumptions about the possible referent and its meaning. For nouns, this is relatively easy as word learners can rely on perceptual and pragmatic cues. For verbs, these two cues are fleeting, and word learners require additional kinds of cues for their meaning to be acquired. Two cues that affect verb learning include linguistic context and contrastive information. The current study used a within group comparison to examine the effect of linguistic context (i.e., rich vs. sparse) and contrastive information (i.e., implicit …

Perspectives Of Middle Eastern Immigrant Parents Regarding Accessing Healthcare Services For Children During The Covid-19 Pandemic In London, Ontario, Sarvenaz Mehrabi

Electronic Thesis and Dissertation Repository

Background: During the COVID-19 pandemic, immigrants have been disproportionally affected and faced difficulties in accessing healthcare services. While it has been reported that the rate of pediatric healthcare utilization decreased during the COVID-19 pandemic, the reasons behind this decline are unclear. It has been suggested that immigrant children might be affected by the COVID-19 pandemic restrictions regarding accessing healthcare services. This study aims to understand the Middle Eastern immigrant parents’ perspectives regarding their access to healthcare services for their children in the London, Ontario, area during the COVID-19 pandemic.

Methods: This qualitative study was conducted with an interpretive description methodology …

Poliovirus Immunity Among Children Aged 6-11 And 36-48 Months In 14 Polio High-Risk Provinces Of Afghanistan: A Health-Facility-Based Study, Sajid Bashir Soofi, Maureen Martinez, Noha H. Farag, William S. Hendley, Derek Ehrhardt, Imran Ahmed, Imtiaz Hussain, William Weldon, Ahmed M. Kassem

Department of Paediatrics and Child Health

Afghanistan is one of two countries where wild poliovirus (WPV) type 1 remains endemic. We conducted a facility-based cross-sectional survey of antipoliovirus antibodies in children in 14 provinces of Afghanistan. The provinces were selected based on programmatic priorities for polio eradication. Children aged 6-11 and 36-48 months attending outpatient clinics were enrolled in the study. We collected venous blood, isolated serum, and conducted neutralization assays to detect poliovirus neutralizing antibodies. A total of 2086 children from the 14 provinces were enrolled. Among the enrolled children, 44.3% were girls; the median age in the 6-11-month group was 9.4 months, and in …

Screen Time Among Children With Mental, Emotional, Developmental, Or Behavioral Problems (Medb) - A Us Population-Based Study, Saral R. Desai, Amanda Shapiro

Tower Health Research Day

No abstract provided.

Bullying Victimization Among Children With Mental, Emotional, Developmental, Or Behavioral Problems - A Us Population-Based Study, Saral Desai

Tower Health Research Day

No abstract provided.

Mosaic Clinical Trial Statistical Analysis Plan Primary Analysis V1.2, Gareth Lingham, Emmanuel Kobia-Acquah, James Loughman, Daniel Ian Flitcroft

Other Resources

The Myopia Outcome Study of Atropine Treatment in Children (MOSAIC) is an investigator-led, double-masked randomised controlled trial of nightly atropine 0.01% eye drops compared to nightly placebo eye drops. A previously published protocol paper outlines the rationale, objective and sample size calculation for the study.¹ A total of 250 participants were enrolled in the study and were randomised 2:1 to active treatment and placebo, respectively. This document outlines the plan for analysis of the 24-month outcomes of the MOSAIC.

Development Of Thai Sensory Patterns Assessment Tool For Children Aged 3–12 Years: Caregiver-Version, Revadee Sutthachai, Anuchart Kaunnil, Supaluck Phadsri, Ilada Pomngen, Mandy Stanley, Tiam Srikhamjak

Research outputs 2022 to 2026

Most existing tools for measuring sensory patterns of children have been developed in Western countries. These tools are complex and may not be culturally appropriate for other contexts that require specific knowledge in the clinical perspective. The aim of this study was to develop a simplified tool called the Thai Sensory Patterns Assessment (TSPA) tool for children. It is designed for children ages 3–12 years old to be completed by their caregiver. The process of creating the tool consisted of drafting a questionnaire and interpreting the result. Partial psychometrics were completed during item development, content validity of items was assessed …

Developing Culturally Appropriate Food Literacy Resources For Aboriginal Children With Foodbank Wa’S Superhero Foods®, Jennifer Tartaglia, Roslyn Giglia, Jill Darby

Research outputs 2022 to 2026

Issue addressed

In Australia, food sovereignty of traditional landowners has been marginalised by the globalisation of food systems and resulted in limited opportunities for children to experience familiar bush tucker foods as healthy choices, particularly in a school environment. Superhero Foods^® themed teaching resources focus on the development of nutrition education materials that included traditional Aboriginal foods together with contemporary foods readily available in regional/remote communities.

Methods

Consultation with an Aboriginal expert and Aboriginal artist; local, regional/remote teachers and stakeholders informed the development of tailored resources including food cartoon characters, school lesson plans and a storybook. The latter was …

Changes In Brain Structural Volume And White Matter Abnormalities In Young Perinatally-Acquired Hiv Infected Children Treated With Antiretroviral Therapy, Netsiri Dumrongpisutikul, Kultida Chaiyagool

Chulalongkorn Medical Journal

Background: Several studies have reported human immunodeficiency virus (HIV) effects on brain volume and found white matter signal abnormality (WMSA) on brain magnetic resonance imaging (MRI). Objective: To evaluate brain volume and WMSA of antiretroviral therapy (ART)-treated perinatally-acquired HIV infected (PHIV) young children. Methods: From November 2016 to March 2018, MRI of 19 ART-treated PHIV young children, aged 12 - 56 months, were analyzed for structural brain volume using FreeSurfer software with manual correction. WMSA were classified into 4 grades. Comparison between the brain volumes and WMSA between early and late ART-treated groups as well as changes of the brain …

Effective Occupational Therapy Interventions To Decrease Picky Eating In Children: A Systematic Review, Savannah L. Jacobsen, Josie Cox, Alli Bos, Cherokee Ferguson, Stacey Smallfield, Molly Whitlow

Student Systematic Reviews: Occupational Therapy

PURPOSE: Picky eating is related to the lack of consumption in food variety by children when shown different foods (Wolstenholme et al., 2020). A 2015 study reported that almost half of children experience a period of picky eating at some point during early childhood, including almost 15% of children for whom picky eating does not resolve by age 6 (Cardona et al., 2015). The purpose of this systematic review is to identify interventions within the scope of occupational therapy that increase food acceptance in children under the age of seven years who demonstrate picky eating characteristics and who have no …

The Ccr2+ Monocyte Subsets Increase In Obese Boys But Not Girls With Abnormally High Carotid Intima-Media Thickness: A Pilot Study, María José Garcés-Hernández, Karen Pedraza-Escudero, Nayely Garibay-Nieto, Joselin Hernández-Ruiz, Jessica Lakshmi Prieto-Chávez, Lourdes Andrea Arriaga-Pizano, Eréndira Villanueva-Ortega, Galileo Escobedo, Aaron Noe Manjarrez-Reyna, Juan C. Lopez-Alvarenga

School of Medicine Publications and Presentations

The differential contribution of monocyte subsets expressing the C-C chemokine receptor 2 (CCR2) to subclinical atherosclerosis in girls and boys is unclear. In this pilot study, we compared classical, intermediate, and nonclassical monocyte subsets expressing CCR2 in 33 obese children of both sexes aged 8 to 16 divided by carotid intima-media thickness (IMT), considering values above the 75th percentile (p75) as abnormally high IMT. Obesity was defined as body mass index above the 95th percentile according to age and sex. Flow cytometry analyses revealed that boys but not girls with IMT ≥ p75 displayed increased CCR2⁺ cell percentage and …

Assessing The Effectiveness Of The Mover Program For Treating Attention Deficit In Children (Mover: Movement Opportunities Through Vestibular Engagement Rhythm), Lindsay B. Williams, Camille Skubik-Peplaski

Student Journal of Occupational Therapy

Background: The purpose of this study was to investigate the effects of participation in a movement- to music program on the attention span of elementary school-aged children who have attention deficits. The hypothesis was that participants would demonstrate improved attention on the Test of Sustained Selective Attention (TOSSA) (Kovacs, 2015).

Methods: This quantitative study involved nine children who participated in four movement-to-music sessions with a staggered stop over a period of six weeks. The study incorporated a single group pre-test/post-test design, and a non-parametric Sign Test was utilized to analyze data from the TOSSA subcategories of concentration, detection, …

Frequency Of Bystander Exposure To Antibiotics For Enteropathogenic Bacteria Among Young Children In Low-Resource Settings, Elizabeth T. Rogawski Mcquade, Stephanie A. Brennhofer, Sarah E. Elwood, Timothy L. Mcmurry, Joseph A. Lewnard, Estomih R. Mduma, Sanjaya Shrestha, Najeeha Talat Iqbal, Pascal O. Bessong, Gagandeep Kang

Department of Paediatrics and Child Health

Children in low-resource settings carry enteric pathogens asymptomatically and are frequently treated with antibiotics, resulting in opportunities for pathogens to be exposed to antibiotics when not the target of treatment (i.e., bystander exposure). We quantified the frequency of bystander antibiotic exposures for enteric pathogens and estimated associations with resistance among children in eight low-resource settings. We analyzed 15,697 antibiotic courses from 1,715 children aged 0 to 2 y from the MAL-ED birth cohort. We calculated the incidence of bystander exposures and attributed exposures to respiratory and diarrheal illnesses. We associated bystander exposure with phenotypic susceptibility of E. coli isolates in …

Early Intervention In Autism Spectrum Disorder: The Need For An International Approach, Amina Abubakar, Patricia Kipkemoi

Institute for Human Development

Globally, autism spectrum disorder (ASD) affects approximately 1 in 100 children. Ideally, a diagnosis is made with the onset of symptoms before 3 years of age; however, a diagnosis may sometimes be delayed until 6 years or later. There has been an increase in ASD research over the last few decades, with many systematic reviews and meta-analyses synthesizing research evidence for ASD interventions in children. Evidence tends to support the notion that intervention for ASD must occur as early as possible, close to the critical periods when early social and communication skills are developing. Therefore, early screening and intervention could …

Clinicians' Perspectives On The Effectiveness Of Trauma - Focused Cognitive Behavioral Therapy With African American Children: A Qualitative Study, Jada Carter

Doctoral Dissertations

Literature exploring clinicians' perspectives on the effectiveness of trauma-focused cognitive behavioral therapy with African American children who suffer from trauma-related disorders is very limited. The current study examined clinicians' perspectives on the TF-CBT model when utilized with this population, including their experiences working with African American children and families with observable types of trauma-related disorders. This research study also explored the various facets of trauma that African Americans encounter in childhood and the barriers that prevent them from receiving adequate mental health care. Thematic analysis was utilized to explore themes that emerged when treating African American children with TF-CBT. Five …

Sugar Shenanigans: Curbing The Added Sugar Epidemic In Children And Adolescents, Amy Krazl, Tonia Mailow

Faculty & Staff Research and Creative Activity

Background: The consumption of added sugar is one of the most dangerous problems regarding the health of society’s youngest generation. Children today consume added sugar at an alarming rate, on average surpassing the daily limit recommended by the American Heart Association. This study aims to educate and empower the child and adolescent population for the purpose of increasing knowledge and improving dietary practices. Methods: An educational program, entitled “Sugar Shenanigans” was delivered to groups of children between the ages of 8 and 13. Data was gathered from pre- and post-tests and “Impact Level Questionnaire” surveys for both participants and parents/guardians …

Exploring The Structural And Functional Effects Of Pediatric Hydrocephalus On The Hippocampus, Lili Meng

Undergraduate Student Research Internships Conference

Hydrocephalus is one of the most common pediatric neurological problems that requires brain surgery in children. Pediatric hydrocephalus is characterized as an abnormal cerebrospinal fluid (CSF) buildup in the brain’s ventricles due to ineffective CSF reabsorption. When this fluid builds up in these cavities, it increases intracranial pressure and has a direct mass effect on the surrounding brain tissue and structures. Ultimately, various functions are affected including—but not limited to—vision, learning, memory, motor control, and hearing. Despite current literature suggesting that hydrocephalus may be associated with reduced hippocampal volume among rats and human adults, findings remain limited in the human …