Medicine and Health Sciences Commons^™

Risk Scores And Machine Learning To Identify Patients With Acute Periprosthetic Joints Infections That Will Likely Fail Classical Irrigation And Debridement., Marjan Wouthuyzen-Bakker, Noam Shohat, Javad Parvizi Md, Alex Soriano

Rothman Institute Papers

The most preferred treatment for acute periprosthetic joint infection (PJI) is surgical debridement, antibiotics and retention of the implant (DAIR). The reported success of DAIR varies greatly and depends on a complex interplay of several host-related factors, duration of symptoms, the microorganism(s) causing the infection, its susceptibility to antibiotics and many others. Thus, there is a great clinical need to predict failure of the "classical" DAIR procedure so that this surgical option is offered to those most likely to succeed, but also to identify those patients who may benefit from more intensified antibiotic treatment regimens or new and innovative treatment …

Does Losing 5-7% Of A Prediabetic’S Body Weight While Completing The Diabetes Prevention Program Decrease Ascvd Risk?, Molly Kucera, T Marchewka, A Craib

Conference Presentation Abstracts

Purpose: According to the Centers for Disease Control (CDC), one-third of adults have prediabetes and are at risk for developing type 2 diabetes, a leading risk factor for cardiovascular disease. The Diabetes Prevention Program (DPP) focuses on lifestyle modifications to help participants lose 5-7% of their body weight and prevent type 2 diabetes. The purpose of this study is to determine whether successful completion of the DPP is associated with a decrease in atherosclerotic cardiovascular disease (ASCVD) risk.
Methods: One-site, prospective cohort study. The DPP was implemented on-site at Farmington Village Family Practice and virtually via Zoom from January 2020 …

Predictors Of Iron Consumption For At Least 90 Days During Pregnancy: Findings From National Demographic Health Survey, Pakistan (2017-2018), Sumera Aziz Ali, Savera Aziz Ali, Shama Razzaq, Nayab Khowaja, Sarah Gutkind, Fazal Ur Rehman, Nadir Suhail

Section of Internal Medicine

Background: Iron supplementation is considered an imperative strategy for anemia prevention and control during pregnancy in Pakistan. Although there is some evidence on the predictors of iron deficiency anemia among Pakistani women, there is a very limited understanding of factors associated with iron consumption among Pakistani pregnant women. Thus, this study aimed to investigate the predictors of iron consumption for at least ≥90 days during pregnancy in Pakistan.
Methods: We analyzed dataset from the nationally representative Pakistan Demographic Health Survey 2017-2018. The primary outcome of the current study was the consumption of iron supplementation for ≥90 days during the pregnancy …

Review: The Bidirectional Relationship Between Mitochondrial Respiratory Chain Inhibition And Import Machinery Malfunction In Parkinson’S Disease, Grace Riggs, Deepa Dabir

Honors Thesis

Parkinson’s Disease (PD) is characterized by a loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) portion of the ventral midbrain, the region of the brain largely responsible for motor control, executive cognitive function, and emotional limbic activity (Sonne 2020). SNpc dopaminergic neurons are more vulnerable than those in other regions due to their high energy demand arising from long, highly branched, unmyelinated axons (Pissadaki & Bolam 2013). They also have a higher basal rate of oxidative phosphorylation, which has been hypothesized to further increase vulnerability in cases of PD (Pacelli et al., 2015). One of the major …

Analysis Of Covid-19 Concerns Raised By The Construction Workforce And Development Of Mitigation Practices, Makram Bou Hatoum, Ali Faisal, Hala Nassereddine, Hadi Sarvari

Civil Engineering Faculty Publications

The coronavirus outbreak has created a global health crisis that has disrupted all industries, including the construction industry. Following the onset of the pandemic, construction workers faced and continue to face unprecedented safety and health challenges. Therefore, construction employers established new safety precautions to protect the health and safety of the workforce and minimize the spread of the virus. The new precautions followed the advice and guidelines offered by different health and safety agencies like the Occupational Safety and Health Administration (OSHA), Centers of Disease Control and Prevention (CDC), and the Associated General Contractors of America (AGC). With construction projects …

Health And Wellness Competencies For An Entry-Level Doctorate Occupational Therapy Course, Teresa Liccardo

UNLV Theses, Dissertations, Professional Papers, and Capstones

The Accreditation Council for Occupational Therapy Education (2018) standards state that the entry-level occupational therapy curriculum must prepare students to practice in a broad range of practice settings, including new and emerging areas of occupational therapy. Health and wellness remain an emerging and not widely populated area of occupational therapy despite the growing research on its importance. Stancanelli (2020) stated that “with the expected growth of health care in the community and the expected increase in the older adult population, occupational therapy students need to be prepared to practice in the community and address health promotion and wellness needs of …

Dnp Final Report: Safety Huddle, Chukwuemeka Ogobuiro

DNP Final Reports

Over 70% of reported sentinel events are due to communication failure between patients, care providers, and/or administration. Safety Huddle has been shown to increase effective communication among healthcare providers. The application of Safety Huddle concept to behavioral health inpatient care is new. Therefore, this scholarly project utilizes the evidence-based practice change steps to improve teamwork and patient safety in the behavioral health inpatient units using Safety Huddle concepts. The Safety Huddle is a team-building tool that increases effective communication among healthcare providers. A review of the literature was conducted. The evidence suggests that Safety Huddle, a tool for effective communication, …

“I Was Like An Autumn Leaf That Looks Pretty From The Outside, But Would Break Once You Touched It”: A Case Study Of The Lived Experience Of Breast Cancer Survival, Wafa Hamad Almegewly, Dinah Gould, Sally Anstey

The Qualitative Report

In this hermeneutic phenomenological case study, we explored the lived experiences of one Saudi Arabian woman, Sahara, living with breast cancer and after, identifying her culture’s impact on the “meaning-making” process. We derived the data from a semi-structured interview and analyzed using interpretive phenomenological analysis (IPA). The themes were: (1) “discourse”: being a breast cancer patient; (2) “sociality”: the complex sense of living with visibility and invisibility; and (3) “selfhood”: regaining the sense of being normal. The study benefits healthcare providers, who need to understand women’s life-world, the impact of culture when designing a program of survival care, and the …

Nur 4050 Family Centered End Of Life Care Across The Life Span Syllabus, Linda Bradley

Open Educational Resources

This course explores the nurses’ involvement in family centered end-of-life care. Principles of hospice and palliative care are used and discussed along with the myriad of needs facing individuals and their families at this time of life. The burden and distress of those facing life’s end and the ability of nurses to offer support for the physical, psychological, social, and spiritual needs of clients and their families are presented.

Protecting Sanitation Workers In Low-Middle Income Countries Amid Covid-19, Muhammad Mainuddin Patwary, Md Riad Hossain, Faysal Kabir Shuvo, Sadia Ashraf, Rabeya Sultana, Md Ashraful Alam

Faculty, Staff and Student Publications

No abstract provided.

Intradural Extramedullary Primary Central Nervous System Melanoma Of The Craniovertebral Junction During Pregnancy: Observations And Outcomes, Fabiola Valenzuela, Sohum Desai

School of Medicine Publications

Background: Primary central nervous system (CNS) melanoma is a rare lesion derived from neural crest precursors. While its management is analogous to metastatic spinal melanoma, the literature does not describe this entity clearly in pregnant patients and the unique implications it presents. Here, we describe the case of a pregnant patient who presented with primary CNS melanoma of the cervical spine.

Case Description: A 27-year-old pregnant patient presented with a 3-month history of neck and interscapular pain. MRI of the cervical spine demonstrated a ventral intradural extramedullary mass adjacent to the C2-C3 vertebral bodies causing severe cord compression. The patient …

Lack Of Observed Tolerance To Diazepam Nasal Spray (Valtoco®) After Long-Term Rescue Therapy In Patients With Epilepsy: Interim Results From A Phase 3, Open-Label, Repeat-Dose Safety Study., Gregory D. Cascino, Daniel Tarquinio, James W. Wheless, R. Edward Hogan, Michael R. Sperling, Kore Liow, Jay Desai, Charles Davis, Adrian L. Rabinowicz, Enrique Carrazana

Department of Neurology Faculty Papers

OBJECTIVE: Tolerance is a known consideration for maintenance use of benzodiazepines and other antiseizure drugs; however, clinical experience suggests that tolerance may not be anticipated with long-term intermittent use of benzodiazepines as rescue therapy. Diazepam nasal spray (Valtoco®) is a proprietary intranasal formulation approved for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (ie, seizure clusters, acute repetitive seizures) in patients with epilepsy aged ≥6 years. Reported here are exploratory analyses investigating whether there was evidence of development of tolerance in an interim analysis of a long-term, phase 3, open-label safety study of diazepam nasal spray.

METHODS: …

Pandemic And Õen Consumption In Japan: Deliberate Buying To Aid The Seller, Kosuke Mizukoshi, Yuichiro Hidaka

Markets, Globalization & Development Review

This dialogue contribution discusses whether it is possible to create favorable new social assistance under the market principles, based on the Ouen or Õen (aid) consumption in Japan. The meaning of consumption has changed due to the COVID-19 pandemic. In Japan, aid consumption is increasing. This means helping local restaurants and producers by willfully and proactively buying and consuming their services and products. This is a favorable form of new social assistance and the result of strong marketing and market functions. The penetration of market forces may surpass pure altruistic behavior such as donations and gifts, by creating new market-linked …

Rethink Everything 2: Markets, Globalization, Development, Nikhilesh Dholakia, Deniz Atik

Markets, Globalization & Development Review

No abstract provided.

You Are What You Think: The Impacts Of Body Weight Perception In Young Adolescent Women, Olivia Ceja

DNP Qualifying Manuscripts

While research suggests a multifactorial array of contributors to adolescent obesity including lack of physical activity, dietary behaviors, psychosocial factors including the perception of being overweight and body dissatisfaction have been more recently associated with unhealthy weights, unhealthy behaviors and amplified risk of obesity. At an all girl’s private college preparatory middle and high school in Los Angeles, amid a competitive and rigorous academic environment, students face additional pressure to succeed and strive for perfection. Although body weight perception can be used to identify students who are at risk for eating disorders at the middle and high school levels, the …

2021-05-02_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Program Development At A Nonprofit Organization For Individuals With Intellectual Disabilities, Victoria E. You

Department of Occupational Therapy Entry-Level Capstone Projects

There are over six million individuals in the United States alone with developmental, or intellectual disabilities (ID). ID is defined by the American Association of Intellectual and Developmental Disabilities (2021) as significantlimitations in both intellectual functioningand in adaptive behavior, which covers many everyday social and practical skills. This type of disability originates before the age of 22. Historically, members of this population have fewer opportunities for engagement than their typically developing peers. This can be for a variety of reasons, including limited funding, the public’s lack of education on ID, and even ableism. Ableism is defined as “discrimination or social …

Screening For Resilience In Pediatric Primary Care, Kaitlin Phelan, Martha Grant Fuller

Doctor of Nursing Practice Final Manuscripts

Introduction: Adversity in childhood increases risk for physical and mental health problems. Children who undergo adverse events can still flourish, due to the concept of resilience. Literature shows that resilience influences health more than adversity, and screening for resilience may improve practice.

Method: A valid screening tool for resilience, The CD-RISC, was given to children twelve and above during their well visit during February 2021 at a clinic in Oceanside, CA. Scores were categorized into four quartiles. Children responding in the lowest two quartiles received provider follow up.

Results: 97 surveys were scored: 39 scoring in the lowest quartile, 19 …

Nursing Assignment: Understanding Covid-19 Vaccines: Specific Strategies To Encourage And Educate Your Patients, Regina G. Lama

Open Educational Resources

Understanding Covid-19 Vaccines: Specific Strategies to Encourage and Educate Your Patients

This assignment focuses on the difference in Covid-19 vaccinations. The nursing student will discuss the different vaccinations and form a teaching plan for the patient in order to encourage the vaccination process. The student will then explore the patients expectations concerning vaccination.

As a presentation the students will be able to evaluate, share and reflect on teaching method.

Choline-Sigma-1r As An Additional Mechanism For Potentiation Of Orexin By Cocaine, Jeffrey Barr, Pingwei Zhao, G Cristina Brailoiu, Eugen Brailoiu

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Orexin A, an endogenous peptide involved in several functions including reward, acts via activation of orexin receptors OX₁ and OX₂, Gq-coupled GPCRs. We examined the effect of a selective OX₁ agonist, OXA (17-33) on cytosolic calcium concentration, [Ca²⁺ ]_i, in neurons of nucleus accumbens, an important area in the reward circuit. OXA (17-33) increased [Ca²⁺ ]_i in a dose-dependent manner; the effect was prevented by SB-334867, a selective OX₁ receptors antagonist. In Ca²⁺-free saline, the OXA (17-33)-induced increase in [Ca²⁺ ]_i was not affected by pretreatment …

Simian Varicella Virus Antibody Response In Recombinant Svv-Siv Immunized Primates, Kiser Horne

Honors Theses

Since its emergence in the early 1980’s HIV has killed approximately 32 million people, and continues to kill over half a million people every year. Significant research into potential vaccines and cures for HIV has been ongoing for decades but has been largely unsuccessful. One of the more promising technologies that is being investigated to develop an HIV vaccine is recombinant vaccine technology. The study presented in this thesis aims to use simian varicella virus (SVV) and simian immunodeficiency virus (SIV) to act as a model for recombinant vaccine development. If a recombinant SVV-SIV vaccine can be proven safe and …

Coronary Artery Disease: An Analysis Of Its Biochemical, Physiological, And Sociological Causes And Effects, Alexander Velazquez

Honors Theses

Coronary Artery Disease (CAD) is a serious condition caused by a buildup of plaque in your coronary arteries, the blood vessels that bring oxygen-rich blood to your heart. It disproportionately affects millions of Americans and thousands of Mississippians. This study presents the results of an evaluation of causation factors of CAD, the physiological impact on the body, and the contributing determinants of CAD on Mississippi populations. Data on Mississippi populations were collected using the Center for Population Studies at the University of Mississippi. A multitude of individuals were evaluated when examining the causes and effects of CAD including men, women, …

The Interhemispheric Connectivity Of The Auditory Cortices, Taylor Stansberry

Honors Theses

Objectives: The corpus callosum of the brain is an important and complex structure that allows communication between the two cerebral hemispheres. In the absence of knowledge about the relationship between the corpus callosum and the auditory cortices, this study aimed to investigate how the structure changes. Specifically, we explored the age associated changes of interhemispheric connectivity between left and right cortices through the corpus callosum.Methods: Using Diffusion Tensor Imaging (DTI) data from enhanced Nathan Kline Institute- Rockland Sample (NKI-RS), we isolated the auditory corpus callosum, or the section of the corpus callosum that transfers auditory information, in each individual subject …

The Effects Of Disclosure On Perceptions Of Different Overt Stuttering Severity Levels, Katelyn Geringswald

Honors Theses

This study measured perceptions of a 17-year-old adolescent male who stutters, relative to select speech skills and personality characteristics, as a function of self-disclosure at various overt severity levels. 983 participants were assigned one of the four conditions, including (1) a no-disclosure control group, (2) mild stuttering severity self-disclosure, (3) moderate stuttering severity self-disclosure, and (4) severe stuttering severity self-disclosure. Participants assigned to the control condition viewed only a primary video stimulus of a 17-year-old adolescent who stutters. Participants assigned to one of the three experimental conditions (mild, moderate, or severe severity disclosure) watched a brief self-disclosure statement, followed by …

Impaired Wound Healing, Fibrosis, And Cancer: The Paradigm Of Recessive Dystrophic Epidermolysis Bullosa, Grace Tartaglia, Qingqing Cao, Zachary Padron, Andrew P. South

Department of Dermatology and Cutaneous Biology Faculty Papers

Recessive Dystrophic Epidermolysis Bullosa (RDEB) is a devastating skin blistering disease caused by mutations in the gene encoding type VII collagen (C7), leading to epidermal fragility, trauma-induced blistering, and long term, hard-to-heal wounds. Fibrosis develops rapidly in RDEB skin and contributes to both chronic wounds, which emerge after cycles of repetitive wound and scar formation, and squamous cell carcinoma—the single biggest cause of death in this patient group. The molecular pathways disrupted in a broad spectrum of fibrotic disease are also disrupted in RDEB, and squamous cell carcinomas arising in RDEB are thus far molecularly indistinct from other sub-types of …

Chronic Exercise And Memory Interference, Lisa Vogelgesang

Honors Theses

This online study examined whether chronic exercise is associated with attenuated memory interference. Sixty-three healthy, young adults completed an interference task (AB/AC-paradigm) and self-reported the number of days and minutes a day they engaged in moderate-to-vigorous physical activity. We found that proactive interference (PI), but not retroactive interference (RI), occurred but none of the exercise modalities significantly impacted PI. Future studies should evaluate whether different interference tasks display diverse sensitivities to exercise-induced changes in memory interference. Moreover, other potential modulating factors, such as the duration and intensity of the exercise should be controlled for.

Analysis Of Multigenerational Behavioral Effects Of Dietary Benzo[A]Pyrene Exposure In Adult Zebrafish, Mary Beth Gillespie

Honors Theses

Benzo[a]pyrene (BaP) is a polycyclic aromatic hydrocarbon that is linked to negative reproductive and developmental effects in humans and animals. Because BaP is carcinogenic, and its continued presence in the environment allows it to be inhaled and ingested, better understanding of the effects of BaP is needed. To determine the behavioral effects of BaP exposure, zebrafish were used as a model. Wild-type zebrafish (5D) underwent two separate 21-day dietary exposures to 2.5 and 25 μg BaP/g fish to compare how BaP exposure affects locomotor activity. Following the dietary exposure, fish were mated to obtain and raise the F1 generation to …

Early Intervention Service Delivery Models In Mississippi: A Cost-Effectiveness Analysis, Claire Harper

Honors Theses

Purpose: The purpose of the present study was to compare two models of service delivery for early intervention in Mississippi from a health care sector perspective: (1) face-to-face therapy in the home environment and (2) a hybrid model (i.e., telepractice and face-to-face therapy in the home environment), in order to compare costs and determine the most cost-effective service delivery of early intervention.

Methods: Children (n = 10) were recruited and determined to qualify for early intervention services through the Mississippi First Steps Early Intervention program. One early intervention provider, a certified SLP, from the northern health region provided early intervention …

Clinical Effectiveness Of Early Intervention Via A Hybrid Teletherapy Model: Children With Autism Spectrum Disorder, Rylan Ponthier

Honors Theses

Purpose: The purpose of the present study was to evaluate the efficacy of Early Intervention (EI) provided via a hybrid model of teletherapy and traditional face-to-face therapy for children with Autism Spectrum Disorder (ASD) compared to children without ASD.

Methods: In total, 10 children were evaluated receiving early intervention via a hybrid model of teletherapy and traditional face-to-face therapy. The children were divided up into two groups. Group 1 consisted of 5 children with ASD and Group 2 consisted of children without ASD. All children were assessed using the Rossetti Infant-Toddler Language Scale (RITLS).

Results: After 20 early intervention sessions, …

The Effect Of Advocate Disclosure On The Perceptions Of A Young Adult Who Stutters, Madeline Simpson

Honors Theses

This between-group study designed weighed the effects of stuttering disclosure on the perceptions of a 17-year-old male who stutters, relative to perceived speech skills and personality characteristics. 1225 participants were included in the dataset analysis with a balanced distribution across all ranges. The conditions used in this study include (1) control condition (no disclosure), as well as experimental conditions including: (2) father disclosure, (3) male coach disclosure, (4) female teacher disclosure, (5) girlfriend disclosure, and (6) female speech-language pathologist. Participants in the control group only viewed the primary video stimulus, while participants in the experimental groups viewed one of the …