Medicine and Health Sciences Commons^™

Survival Benefit For Individuals With Constitutional Mismatch Repair Deficiency Undergoing Surveillance, Carol Durno, Ayse Bahar Ercan, Vanessa Bianchi, Melissa Edwards, Melyssa Aronson, Melissa Galati, Eshetu G. Atenafu, Gadi Abebe-Campino, Abeer Al-Battashi, Naureen Mushtaq

Section of Haematology/Oncology

Purpose: Constitutional mismatch repair deficiency syndrome (CMMRD) is a lethal cancer predisposition syndrome characterized by early-onset synchronous and metachronous multiorgan tumors. We designed a surveillance protocol for early tumor detection in these individuals.
Patients and methods: Data were collected from patients with confirmed CMMRD who were registered in the International Replication Repair Deficiency Consortium. Tumor spectrum, efficacy of the surveillance protocol, and malignant transformation of low-grade lesions were examined for the entire cohort. Survival outcomes were analyzed for patients followed prospectively from the time of surveillance implementation.
Results: A total of 193 malignant tumors in 110 patients were identified. Median …

County-Level Factors That Influenced The Trajectory Of Covid-19 Incidence In The New York City Area, Ashley Wendell Kranjac, Dinko Kranjac

Sociology Faculty Articles and Research

More than a century of research has shown that sociodemographic conditions affect infectious disease transmission. In the late spring and early summer of 2020, reports of the effects of sociodemographic variables on the spread of COVID- 19 were used in the media with minimal scientific proof attached. With new cases of COVID-19 surging in the United States at that time, it became essential to better understand how the spread of COVID-19 was varying across all segments of the population. We used hierarchical exponential growth curve modeling techniques to examine whether community socioeconomic characteristics uniquely influence the incidence of reported COVID-19 …

Molecular Characterization Of, And Antimicrobial Resistance In, Clostridioides Difficile From Thailand, 2017–2018, Korakrit Imwattana, Papanin Putsathit, Daniel R. Knight, Pattarachai Kiratisin, Thomas V. Riley

Research outputs 2014 to 2021

Antimicrobial resistance (AMR) plays an important role in the pathogenesis and spread of Clostridioides difficile infection (CDI). Many antimicrobials, such as fluoroquinolones, have been associated with outbreaks of CDI globally. This study characterized AMR among clinical C. difficile strains in Thailand, where antimicrobial use remains inadequately regulated. Stool samples were screened for tcdB and positives were cultured. C. difficile isolates were characterized by toxin profiling and PCR ribotyping. Antimicrobial susceptibility testing was performed by agar incorporation, and whole-genome sequencing and AMR genotyping were performed on a subset of strains. There were 321 C. difficile strains isolated from 326 stool samples. …

Raman Spectroscopic Characterisation Of Non Stimulated And Stimulated Human Whole Saliva, Genecy Calado, Isha Behl, Hugh Byrne, Fiona Lyng

Articles

Human saliva is a unique biofluid which can reflect the physiopathological state of an individual. The wide spectrum of molecules present in saliva, compounded by the close association of salivary composition to serum metabolites, can provide valuable information for clinical diagnostic applications through highly sensitive vibrational spectroscopic techniques such as Raman spectroscopy. However, the nature of saliva, in terms of collection and patient-related characteristics, can be considered factors which may strongly affect the Raman spectral profile of salivary samples and disrupt the search for specific salivary biomarkers in the detection of diseases. The main objective of this study was to …

U-251mg Spheroid Generation Using Low Attachment Plate Method Protocol, Lara J. Carroll, Brijesh K. Tiwari, James F. Curtin, Janith Wanigasekara

Articles

3D cell culture is a process used to grow cells in vitro to mimic an in vivo environment. 3D cell models are very useful for understanding disease mechanisms and exploring drug therapeutics. 3D cultures can be grown from cells taken from cancer organoids in patients. Once grown, they can be used to screen for small molecule drugs or they can be genetically modified in order to analyse disease pathways or predict the toxicity or efficacy of a drug treatment. These cultures decrease the need to use animals in research and provides more reliable results as it uses human physiology. This …

Interfacial Dynamics And Ionic Transport Of Radiologic Contrast Media In Carbohydrate Matrix: Utility And Limits Of X-Ray Imaging, Lin Mousa, Hayley Sanchez, Subhendra Sarkar, Zoya Vinokur

Publications and Research

Hello, our names are Lin Mousa and Hayley Sanchez, this semester we participated in a research project dedicated to analyzing the interactions of contrast media with the molecular components of fruits to compare how they would react with the human brain. This project involved the injection of fruits with varying contrasts and the imaging of the diffusion and interactions of the contrast within the fruits with X-rays. With setup technical parameters on the x-ray equipment images were taken with identical setups at an hourly rate for several days. The final results of this experiment indicated that contrasts such as Gadolinium …

Neurological Diseases And Covid-19: Prospective Analyses Using The Uk Biobank, Nicola Veronese, Lee Smith, Mario Barbagallo, Gianluigi Giannelli, Maria Gabriella Caruso, Anna Maria Cisternino, Maria Notarnicola, Chao Cao, Thomas Waldhoer, Lin Yang

2020-Current year OA Pubs

COVID-19 (Coronavirus disease-19) may present with neurological signs, but whether people already affected by neurological conditions are at a higher risk of contracting COVID-19 is still not known. We, therefore, aimed to investigate the association of previously diagnosed neurological conditions with COVID-19. 502,536 community-dwelling UK Biobank participants (54.4% male, mean age 56.6 ± 10.3 years) were included. Among these, 57,463 participants had a diagnosis of neurological conditions (11.43%) and a total of 1326 COVID-19-positive cases were identified (0.26%). Neurological conditions were identified through medical history and linkage to data on hospital admissions (ICD-10 code G00-G99). COVID-19 presence was diagnosed using …

Willingness To Attend Sex Venues In The Context Of The Covid-19 Pandemic In New York City: Results From An Online Survey With Sexual And Gender Minority Individuals, Étienne Meunier, Anne E. Sundelson, Stephen Tellone, Daniel Alohan, Celia B. Fisher, Christian Grov

Covid-19 Digital Research

Collective sex venues (places where people have sex in groups or in the presence of others, such as bathhouses or sex clubs) are locations where SARS-CoV-2 transmission is likely to occur. We conducted an online survey to examine the impact of the COVID-19 pandemic among 342 sexual and gender minority (SGM) individuals who had attended collective sex venues (CSV) in New York City (NYC) in the prior year. Almost 1 in 10 (9.9%) participants reported having received a positive test for SARS-CoV-2 infection or antibodies. Although a minority (27.5%) of participants reported being comfortable attending a CSV during the COVID-19 …

Incidence Of Accessory Brachialis Muscle, Variations In Its Insertion And Relation With Surrounding Neurovascular Structures, Mamatha Tonse

Kasturba Medical College, Mangalore Theses and Dissertations

No abstract provided.

Effect Of Change In Usmle Step 1 Grading On Orthopaedic Surgery Applicants: A Survey Of Orthopaedic Surgery Residency Program Directors., Alex Gu, Jacob Farrar, Safa C. Fassihi, Seth Stake, Pradip Ramamurti, Chapman Wei, Lauren E Wessel, Duretti T Fufa, Raj D. Rao

Orthopaedic Surgery Faculty Publications

No abstract provided.

Forward Together Update [Johnson & Johnson Vaccine Clinic], May 4, 2021, University Of Northern Iowa

UNI Response to COVID-19

Announces the availability of walk-in appointments for the Johnson & Johnson vaccine clinic

2021-05-04_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Implementation Of A Zoom Toolkit For Web-Based, Evidence-Based Health Promotion Programs, Samantha Brown, Julie Shelton

Nursing DNP Projects

This article describes a project to promote the utilization of online evidence-based programs for the self-management of chronic conditions for older adults. The project has been developed based on the findings of a comprehensive review of literature on the outcomes of online health promotion programs for people with chronic health conditions, and on the training needed prior to starting an online course. The project was completed in partnership with WellConnect^®, a non-profit organization facilitating community-based programs that support people in Southeast Minnesota with tools and resources needed to improve individuals’ health and wellbeing.

Interviews with WellConnect^® stakeholders, …

2021-05-04_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2021-05-04_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-526911--,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The information below represents COVID-19 data reported directly to MDHHS by licensed and operating Skilled Nursing, Home for the Aged and Adult Foster Care facilities (licensed to serve 13 or more individuals) in Michigan from January 1, 2020. All long-term care facilities additionally have an obligation to report COVID-positive residents and/or staff …

Coronavirus Update 5-4-2021, The Coronavirus Planning Team

University Briefings & Virtual Events

We want to remind you to upload your vaccination card once you have been fully vaccinated.

Sarcomere Function Activates A P53-Dependent Dna Damage Response That Promotes Polyploidization And Limits In Vivo Cell Engraftment., Anthony M Pettinato, Dasom Yoo, Jennifer Vanoudenhove, Yu-Sheng Chen, Rachel Cohn, Feria A Ladha, Xiulan Yang, Ketan Thakar, Robert Romano, Nicolas Legere, Emily Meredith, Paul Robson, Michael Regnier, Justin L Cotney, Charles E Murry, J Travis Hinson

Faculty Research 2021

Human cardiac regeneration is limited by low cardiomyocyte replicative rates and progressive polyploidization by unclear mechanisms. To study this process, we engineer a human cardiomyocyte model to track replication and polyploidization using fluorescently tagged cyclin B1 and cardiac troponin T. Using time-lapse imaging, in vitro cardiomyocyte replication patterns recapitulate the progressive mononuclear polyploidization and replicative arrest observed in vivo. Single-cell transcriptomics and chromatin state analyses reveal that polyploidization is preceded by sarcomere assembly, enhanced oxidative metabolism, a DNA damage response, and p53 activation. CRISPR knockout screening reveals p53 as a driver of cell-cycle arrest and polyploidization. Inhibiting sarcomere function, or …

How Should We Set Pandemic Capacity Limits For Restaurants & Bars?, Eric A. Schiff

SyracuseCoE

Restaurants and bars are places where airborne diseases like COVID-19 are easily transmitted from one patron to another. To reduce the number of infections during the pandemic, public health authorities have often shuttered them. When re-opening is allowed, restaurants and bars are known to add significantly to new infections.

To moderate the number of infections from bars and restaurants, health authorities are experimenting with reducing their capacity limits. We have made calculations of these limits based on the principle of limiting COVID- 19 cases from restaurants and bars to a specific, low rate. The calculations are based on the daily …

Perceived Stress May Mediate The Relationship Between Antenatal Depressive Symptoms And Preterm Birth: A Pilot Observational Cohort Study, Sharifa Bashir Lalani, Aliyah Dosani, Ntonghanwah Forcheh, Shahirose Sadrudin Premji, Sana Siddiqui, Kiran Shaikh, Ayesha Mian, Ilona S Yim Ilona S Yim, Maternal-Infant Global Health Team (Might) Collaborators In Research

School of Nursing & Midwifery

Background: Screening for changes in pregnancy-related anxiety and depressive symptoms during pregnancy may further our understanding of the relationship between these two variables and preterm birth.
Objectives: To determine whether changes in pregnancy-related anxiety and depressive symptoms during pregnancy influence the risk of preterm birth among Pakistani women; explore whether perceived stress moderates or mediates this relationship, and examine the relationship between the various components of pregnancy-related anxiety and preterm birth.
Methods: A prospective cohort study design was used to recruit a diverse sample of 300 low-risk pregnant women from four centers of Aga Khan Hospital for Women and Children …

2021-05-04_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2021-05-04_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Monday - Saturday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …

Covid-19 Newsletter (Vol. 70), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

Menstrual Dysfunction As The Leading Clinical Marker For The Future Development Of The Female Athlete Triad: A Meta-Analysis, Sydney Hotz

Health and Kinesiology Theses

The Female Athlete Triad is a diagnosable medical condition that is under researched and very prevalent in female sports today. The development of the Female Athlete Triad, or any of its components, can negatively impact many aspects of a female athlete’s life. If clinical markers could be identified that indicate future development of the Triad, it could potentially help prevent occurrence of the condition and greatly reduce the number of female’s that have to suffer from it. Menstrual dysfunction could be the leading clinical marker for the future development of the Triad. This meta-analysis seeks to explore the possible association …

Assessing Transgender Inclusion Within A Veterans Healthcare System: A Delphi Study, Kathy-Jo B. Lee

Nursing Theses and Dissertations

Transgender veterans have specific health care needs and often experience profound health disparities, barriers to accessing care, and varying degrees of stigma and discrimination. Yet, there is a lag in research regarding transgender persons in terms of the extent and impact of diversity and inclusion within healthcare. There is a need to further define inclusion and examine how this concept is operationalized in the healthcare settings. This study addressed the gap in knowledge gained from transgender healthcare research by establishing a consensus definition of transgender inclusion as well as identified contributing factors. The study also compared the end user perspectives …

A Tailored Multicomponent Intervention In Primary Care For Survivors Of Adverse Childhood Experiences (Aces), Rebecca L. Peterson

Evidence-Based Practice Project Reports

Adverse childhood experiences (ACEs) include 10 traumatic events of abuse, neglect, and household dysfunction that occur before 18 years of age. Adverse childhood experiences affect greater than 60% of the population, and approximately one in six individuals affirm that they have experienced four or more types of ACEs. They are associated with negative, long-term health outcomes in adults, including 9 out of the 10 leading causes of death in the United States (Centers for Disease Control and Prevention, n.d.; Felitti et al., 1998). The purpose of this evidence-based practice project was to implement a tailored, multicomponent intervention to mitigate the …

Evaluating The Effectiveness Of A Continuing Education Program For The Improvement Of Clinical Reasoning Skills Among Nurses Using The Early Warning Scoring Protocol, Lisa Bellingham

Kean Quest

This pilot study evaluates the effectiveness of a continuing education (CE) program on nurses' clinical reasoning skills in utilizing the Early Warning Scoring (EWS) protocol. The CE program aimed at improving nurses' competency in using the EWS protocol for early warning detection through clinical reasoning skills training. The CE program involved a two-hour session that included an overview of the clinical reasoning framework, three simulated patient scenarios, and a reflective dialogue. Due to COVID-19 restrictions, a convenience sample of seven registered nurses participated in the program. Simulated scenarios were given to the participants to complete before and after the CE …

Guided Imagery And Sentinel Lymph Node Biopsy Pain, Brandy Alicia Kirk

Evidence-Based Practice Project Reports

The standard of care in the treatment for women diagnosed with breast cancer includes identification and biopsy of the sentinel lymph nodes (SLN) of the breast (Chaterjee et al., 2017; Kneece, 2017). The process of identifying the SLNs involves radioisotope injections into or near the areola. Because this area is highly sensitive, women report this procedure to be considerably painful. The purpose of this evidence-based practice (EBP) project was to determine if the provision of a 5-minute session of guided imagery (GI), as a complementary alternative medicine, prior to SLN injections was effective in mitigating reports of procedural pain. A …

Dnp Final Report: Teamstepps For Nursing Students, Jennifer Matranga

DNP Final Reports

The purpose of this paper is to discuss the DNP project, which focused on improving communication skills for associate degree nursing students. The background and significance of this problem was identified, a systematic review of the literature was completed, and TeamSTEPPS, based on the body of evidence, was implemented in a clinical immersion setting. The project objectives were to implement communication techniques, using TeamSTEPPS, as recommended from the body of evidence. The anticipated outcomes were that nursing students would have increased confidence in asking questions in the clinical setting, reduced fear of communicating, and improved patient safety. A review of …

Identifying And Predicting Food Parenting Practice Profiles Among Canadian Parents, Claire N Tugault-Lafleur, Olivia De-Jongh González, Teresia M O'Connor, Sheryl O Hughes, Louise C Mâsse

Children’s Nutrition Research Center Staff Publications

Background: Food parenting practices (FPP) can affect children's eating behaviours, yet little is known about how various FPP co-occur. The primary aim was to identify profiles of FPPs use among Canadian parents. Secondary aims included examining sociodemographic correlates of FPP profiles and evaluating whether children's eating behaviours differed across FPP profiles.

Methods: Parents (n = 799) of 5-12-year-old children completed a validated FPP Item Bank and the Children's Eating Behaviour Questionnaire. Latent Class Analysis (LCA) was used to identify distinct FPP profiles. Regression analyses were used to explore associations between FPP profiles, sociodemographic variables (race, sex and education) and children's …

Working With Bilingual Children: Speech Language Pathology, Paola Prado

Graduate Independent Studies - Communication Sciences and Disorders

No abstract provided.