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Articles 9391 - 9420 of 21412
Full-Text Articles in Medicine and Health Sciences
Implementation And Sustainability Factors Of Two Early-Stage Breast Cancer Conversation Aids In Diverse Practices, Danielle Schubbe, Mary C Politi, Julie Margenthaler, Courtney Goodwin, Et Al
Implementation And Sustainability Factors Of Two Early-Stage Breast Cancer Conversation Aids In Diverse Practices, Danielle Schubbe, Mary C Politi, Julie Margenthaler, Courtney Goodwin, Et Al
2020-Current year OA Pubs
BACKGROUND: Conversation aids can facilitate shared decision-making and improve patient-centered outcomes. However, few examples exist of sustained use of conversation aids in routine care due to numerous barriers at clinical and organizational levels. We explored factors that will promote the sustained use of two early-stage breast cancer conversation aids. We examined differences in opinions between the two conversation aids and across socioeconomic strata.
METHODS: We nested this study within a randomized controlled trial that demonstrated the effectiveness of two early-stage breast cancer surgery conversation aids, one text-based and one picture-based. These conversation aids facilitated more shared decision-making and improved the …
Art And Empathy: Self Discovery In A Dark Forest, Younser Lee
Art And Empathy: Self Discovery In A Dark Forest, Younser Lee
Graduate School of Art Theses
According to the National Institute of Mental Health, 40 million people report feelings of depression, anxiety, and stress as the world moves at an increasingly rapid pace and faces unprecedented challenges. However, many ignore these negative thoughts and fail to acknowledge them as a serious issue. My art, which shares my own experiences, creates safe, cathartic places for viewers to think about their own emotional experiences. Crucial to this process is my use of daily objects and the creation of individualized, participatory, and multisensory experiences.
My art relates to daily life and the negative emotions that we experience daily. I …
Upregulation Of Inflammatory Cytokines In Pulmonary Embolism Using Biochip-Array Profiling., Emily Bontekoe, Yevgeniy Brailovsky, Debra Hoppensteadt, Jack Bontekoe, Fakiha Siddiqui, Joshua Newman, Omer Iqbal, Trent Reed, Jawed Fareed, Amir Darki
Upregulation Of Inflammatory Cytokines In Pulmonary Embolism Using Biochip-Array Profiling., Emily Bontekoe, Yevgeniy Brailovsky, Debra Hoppensteadt, Jack Bontekoe, Fakiha Siddiqui, Joshua Newman, Omer Iqbal, Trent Reed, Jawed Fareed, Amir Darki
Department of Medicine Faculty Papers
The complex pathophysiology of pulmonary embolism (PE) involves hemostatic activation, inflammatory processes, cellular dysfunction, and hemodynamic derangements. Due to the heterogeneity of this disease, risk stratification and diagnosis remains challenging. Biochip-array technology provides an integrated high throughput method for analyzing blood plasma samples for the simultaneous measurement of multiple biomarkers for potential risk stratification. Using biochip-array method, this study aimed to quantify the inflammatory biomarkers such as interleukin (IL)-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, vascular endothelial growth factor (VEGF), interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1), and epidermal growth factor (EGF) in 109 clinically …
Week Of May 10, 2021, New York Medical College
Week Of May 10, 2021, New York Medical College
InTouch
- La Casita de la Salud Expands Services to Offer Medical and Dental Care in Westchester
- NYMC's Days of Giving Raises Nearly $345,000 to Support Student Scholarships
- NYMC Receives Grant from Alpha Omega Alpha to Support Educational Leadership Program to Combat Systemic Racism and Implicit Bias
- The Office of Diversity and Inclusion Hosts Leveraging Diversity in Academic Medicine Seminar
- School of Medicine Hosts Gold Humanism Honor Society Induction Ceremony for the Class of 2022
- Alpha Omega Alpha Iota Chapter Celebrates Academic Distinction During Annual Induction Ceremony
- NYMC Faculty Member, Abhay Dhand, M.D., Presents Keynote Address at Touro Research Day: COVID-19 One …
A National Study On The Relationship Between Programmatic Factors And Athletic Training Education Board Of Certification Pass Rates, Leslie Rippon
A National Study On The Relationship Between Programmatic Factors And Athletic Training Education Board Of Certification Pass Rates, Leslie Rippon
Seton Hall University Dissertations and Theses (ETDs)
In athletic training (AT) education, the first-time BOC pass rate is a significant marker of a program’s success, and the Commission on Accreditation of Athletic Training Education (CAATE) requires programs to maintain a first-time 3-year aggregate BOC examination pass rate over 70%. There is limited published research on BOC pass rates on Professional Masters’ (PM) programs. Therefore, it is essential to identify modifiable factors that have a relationship with first-time pass rates. This study's aim was to investigate the relationships between programmatic factors and the first-time BOC pass rate for PM AT students while controlling for student and institutional factors. …
2021-05-09_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services
2021-05-09_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services
Michigan COVID-19 Syndromic Surveillance System Data
The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.
Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …
Alzheimer’S And Patient Caregiver Burnout: A Comprehensive Review Of The Literature, Madeline J. Hekeler
Alzheimer’S And Patient Caregiver Burnout: A Comprehensive Review Of The Literature, Madeline J. Hekeler
Senior Honors Projects, 2020-current
The term ‘silent epidemic’ has become fitting for Alzheimer’s disease, as it is now the sixth leading cause of death in the US. Caring for AD patients at home in the US costs billions of dollars each year. The current comprehensive literature review discusses the background/history of AD, pathology and modes of transmission of AD, behavioral and natural risk factors, prevention and treatment options, and how the aforementioned factors contribute to caregiver burnout and subsequently affect the AD patient. The extensive examination of the literature determined several gaps to be addressed. More specifically, burnout among AD caregivers has become an …
Academic Stressors, Perceived Stress, And Coping Strategies Among Undergraduate Students, Danielle J. Levin
Academic Stressors, Perceived Stress, And Coping Strategies Among Undergraduate Students, Danielle J. Levin
Senior Honors Projects, 2020-current
Stress is common among college students and is a predominant factor interfering with academic performance. This study evaluated how college students perceive their level of stress, the coping strategies used, and the use of resources to offset stress offered by the university. This study showed that overall, undergraduate students at JMU experienced moderate levels of stress. Pressure to succeed, balancing coursework, and lack of motivation were the most prevalent academic stressors experienced by students. This study provides evidence that perceptions of stress greatly impact student behavior and use of coping strategies. Variation in coping strategies among students highlights the importance …
Integrating Ethics And The Opioid Crisis Via Simulation: An Ethical Debriefing For Nursing Students, Raigan A. J. Shackelford
Integrating Ethics And The Opioid Crisis Via Simulation: An Ethical Debriefing For Nursing Students, Raigan A. J. Shackelford
Senior Honors Projects, 2020-current
Over the past three decades, opioid medication misuse and abuse has skyrocketed. The increase in improper use has created the need for more frequent exercise of ethical reasoning skills in practice. This study was designed to determine the effect of an ethics-centered debriefing exercise following a standardized simulation scenario concerning opioid misuse/abuse on nursing students’ value of and perceived confidence in ethical reasoning skills. 18 senior level BSN students at James Madison University in Harrisonburg, VA, participated in an ethics- focused debriefing exercise following the simulated scenario. The debriefing was constructed using the ANA Code of Ethics and James Madison …
Outcomes Following Discectomy For Far Lateral Disc Herniation Are Not Predicted By Obstructive Sleep Apnea, John Connolly, Austin J. Borja, Svetlana Kvint, Donald K. E. Detchou, Gregory Glauser, Krista Strouz, Scott D. Mcclintock, Paul J. Marcotte, Neil R. Malhotra
Outcomes Following Discectomy For Far Lateral Disc Herniation Are Not Predicted By Obstructive Sleep Apnea, John Connolly, Austin J. Borja, Svetlana Kvint, Donald K. E. Detchou, Gregory Glauser, Krista Strouz, Scott D. Mcclintock, Paul J. Marcotte, Neil R. Malhotra
Mathematics Faculty Publications
Introduction: Previous studies have demonstrated that obstructive sleep apnea (OSA) is associated with adverse postoperative outcomes, but few studies have examined OSA in a purely spine surgery population. This study investigates the association of the STOP-Bang questionnaire, a screening tool for undiagnosed OSA, with adverse events following discectomy for far lateral disc herniation (FLDH). Methods: All adult patients (n = 144) who underwent FLDH surgery at a single, multihospital, academic medical center (2013-2020) were retrospectively enrolled. Univariate logistic regression was performed to evaluate the relationship between risk of OSA (low- or high-risk) according to STOP-Bang score and postsurgical outcomes, including …
Symptoms And Testing For Covid-19, Daniel Gurvich, Laura E. Fasulo, Micah Goltsman
Symptoms And Testing For Covid-19, Daniel Gurvich, Laura E. Fasulo, Micah Goltsman
Publications and Research
No abstract provided.
Pediatric Health Literacy, Morgan E. Sapper, Grace G. Lloyd
Pediatric Health Literacy, Morgan E. Sapper, Grace G. Lloyd
Senior Honors Projects, 2020-current
Abstract
Background: Unless you are a healthcare provider or licensed healthcare professional, understanding the United States healthcare system and its accompanying medical jargon can be confusing and overwhelming to try to navigate. Even more difficult is comprehending what resources are available to specific populations and how to gain the most benefit from these offered resources. Limited health literacy skills have been identified as the largest barrier in identifying an individual’s health outcomes. Health affects every stage of life. The purpose of this paper is to analyze what health literacy implementations look like as well as the age and developmental stage …
Joint Effects Of Ethnic Enclave Residence And Ambient Volatile Organic Compounds Exposure On Risk Of Gestational Diabetes Mellitus Among Asian/Pacific Islander Women In The United States, Andrew D. Williams, Sandie Ha, Edmond Shenassa, Lynne C. Messer, Jenna Kanner, Pauline Mendola
Joint Effects Of Ethnic Enclave Residence And Ambient Volatile Organic Compounds Exposure On Risk Of Gestational Diabetes Mellitus Among Asian/Pacific Islander Women In The United States, Andrew D. Williams, Sandie Ha, Edmond Shenassa, Lynne C. Messer, Jenna Kanner, Pauline Mendola
OHSU-PSU School of Public Health Faculty Publications and Presentations
Background: Asian/Pacific Islander (API) communities in the United States often reside in metropolitan areas with distinct social and environmental attributes. Residence in an ethnic enclave, a socially distinct area, is associated with lower gestational diabetes mellitus (GDM) risk, yet exposure to high levels of air pollution, including volatile organic compounds (VOCS), is associated with increased GDM risk. We examined the joint effects of ethnic enclaves and VOCs to better understand GDM risk among API women, the group with the highest prevalence of GDM.
Methods:
We examined 9069 API births in the Consortium on Safe Labor (19 hospitals, 2002–2008). API ethnic …
2021-05-08_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services
2021-05-08_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services
Cumulative Michigan COVID-19 Data
The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.
The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Monday - Saturday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …
Intangible Cultural Heritage: A Benefit To Climate-Displaced And Host Communities, Gül Aktürk, Martha B. Lerski
Intangible Cultural Heritage: A Benefit To Climate-Displaced And Host Communities, Gül Aktürk, Martha B. Lerski
Publications and Research
Climate change is borderless, and its impacts are not shared equally by all communities. It causes an imbalance between people by creating a more desirable living environment for some societies while erasing settlements and shelters of some others. Due to floods, sea level rise, destructive storms, drought, and slow-onset factors such as salinization of water and soil, people lose their lands, homes, and natural resources. Catastrophic events force people to move voluntarily or involuntarily. The relocation of communities is a debatable climate adaptation measure which requires utmost care with human rights, ethics, and psychological well-being of individuals upon the issues …
2021-05-08_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services
2021-05-08_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services
Michigan COVID-19 Syndromic Surveillance System Data
The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.
Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …
2021-05-08_Michigandaily_Covidmap, Michigan Department Of Health & Human Services
2021-05-08_Michigandaily_Covidmap, Michigan Department Of Health & Human Services
Daily Michigan COVID-19 Update
The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.
The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.
The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …
Governor Gains: A Remote Program Connecting Home And School, Madison L. Michels
Governor Gains: A Remote Program Connecting Home And School, Madison L. Michels
Occupational Therapy Capstone Presentations
The purpose of this capstone project was to create and implement the Governor Gains remote home program aimed at increasing parent involvement in home-based activities to promote academic performance among children with disabilities. This capstone experience was completed within the Pierre, SD Public School System, specifically with elementary-aged students. An occupational therapy student worked with a faculty mentor (OTD), site mentor(OTR/L), and interprofessional team (physical therapists, speech therapists, psychologists, and general and special education teachers) to complete this project. The capstone project began with advanced clinical practice then transitioned into program development. Governor Gains provided a focus on fine motor …
Occupational Therapy Services For Sheltered Individuals Experiencing Homelessness, Ariana Oorlog
Occupational Therapy Services For Sheltered Individuals Experiencing Homelessness, Ariana Oorlog
Occupational Therapy Capstone Presentations
There is a need for interventions to help people experiencing homelessness learn home management, transportation, and health maintenance skills. The purpose of this capstone experience was to administer an occupational therapy program to support sheltered adults experiencing homelessness to improve their preparedness in obtaining and maintaining housing, community reintegration, and long-term success in life. I completed the capstone experience at Hope Street of Siouxland, a sober living home for adult males who are recovering from homelessness, addiction, and mental illness. I completed a Needs Assessment and developed the program based on the identified needs of Hope Street guests. The program …
Evaluation Of A Renewal Room For Nurses, Danica Lee, Courtney Batra, Megan Knutson
Evaluation Of A Renewal Room For Nurses, Danica Lee, Courtney Batra, Megan Knutson
Doctor of Nursing Practice Projects: College of Nursing
Wellness is an emerging and prominent issue in recent years, and specifically has a heavy influence on healthcare institutions and their employees. Having an outlet for self-care is important in developing resilience to life’s challenges. A Renewal Room is one approach to encouraging resilience and mental health restoration. The purpose of this study is to evaluate the usability of a wellness room for nurses. Data were collected in the form of an electronic survey that examined the utility (does it do what users need) and usability of the Renewal Room by determining who uses the room, when it is used, …
Machine Learning Applied To Colloidal Properties Of Perfluorocarbon Nanoemulsions For Imaging In Ards/Ali, Marco Hosfeld
Machine Learning Applied To Colloidal Properties Of Perfluorocarbon Nanoemulsions For Imaging In Ards/Ali, Marco Hosfeld
Electronic Theses and Dissertations
Acute Respiratory distress Syndrome (ARDS) and Acute Lung Injury (ALI) are inflammatory lung pathologies consisting of non-hydrostatic pulmonary edema leading to hypoxia and impaired gas exchange in the lungs. ARDS/ALI is both difficult to study and treat as it is not in itself a specific pathology but rather a syndrome consisting of many pathologies that vary case by case. It is, however, consistently characterized by an explosive acute inflammatory response in the lung parenchyma leading to hypoxia. Although time has seen to an increase in the understanding of ARDS/ALI, the mortality rate remains in the range of 30-50%. For these …
Design, Synthesis And Antineoplastic Evaluation Of A Variety Of Small Molecule Scaffolds, Bader Huwaimel
Design, Synthesis And Antineoplastic Evaluation Of A Variety Of Small Molecule Scaffolds, Bader Huwaimel
Theses & Dissertations
Several appealing strategies emerged for selective anticancer therapy. Mitochondrial respiratory complex II (CII) is a potential target for many human diseases, including cancer. We have designed, synthesized, and characterized a library of potent CII inhibitors atpenin A5 and diazoxide analogs with enhanced ‘drug-likeness’ and evaluated their antineoplastic activity. Several of these derivatives showed greater activity and selectivity to inhibit the CII. Design aspects of lead derivatives (16c) include optimum ligand lipophilicity efficiency of >5, and half-life of >3 hours. This derivative displayed potent and selective inhibition of cell proliferation in both multiple human prostate cancer cell lines and …
Design, Synthesis And Evaluation Of Novel Inhibitors Of Type 5 And 10 17Β-Hydroxysteroid Dehydrogenases, Ahmed Morsy
Design, Synthesis And Evaluation Of Novel Inhibitors Of Type 5 And 10 17Β-Hydroxysteroid Dehydrogenases, Ahmed Morsy
Theses & Dissertations
17β-Hydroxysteroid dehydrogenases (17β-HSDs) are essential enzymes in steroid metabolism. More and more evidence points to the pivotal contributions of these enzymes in various other metabolic pathways. Therefore, the latest research results give new insights into the complex metabolic interconnectivity of the 17β-HSDs with human diseases. This dissertation focuses on the metabolic activities of type 5 and 10 17β-HSDs. More specifically, regarding 17β-HSD5 contributions to the progression of prostate cancer (PCa) and 17β-HSD10 aggravation of amyloid-beta (Aβ)-induced toxicity in Alzheimer's disease (AD).
The second leading cause of cancer-related death in males is PCa, with the highest incidence rate of all cancers …
The Effect Of Polyunsaturated And Saturated Fatty Acids On Seizure Presence And Severity In A Cohort Of Subjects In An Epilepsy Monitoring Unit, Jana K. Wells
Theses & Dissertations
Ketogenic diet therapies (KDTs) have been used to treat epilepsy for nearly 100 years. Although effective, restrictive diet patterns and unknown impacts on long-term health outcomes often prevent their use as first-line therapy. To date, a distinct mechanism of action for KDTs has not been determined and evidence suggests fatty acids (FAs) may play a role in eliciting anti-seizure effects. This dissertation aimed to provide insights into the effect of polyunsaturated fatty acids (PUFAs) and saturated fatty acids (SFAs) on seizure presence and severity through the analysis of dietary intake in a cohort of patients admitted to an epilepsy monitoring …
Neural Oscillatory Activity Serving Sensorimotor Control Is Regulated By The Mitochondrial Redox Environment In Health And Disease, Rachel Spooner
Neural Oscillatory Activity Serving Sensorimotor Control Is Regulated By The Mitochondrial Redox Environment In Health And Disease, Rachel Spooner
Theses & Dissertations
Despite effective regimens of combination antiretroviral therapy, individuals with HIV are still at higher risk for developing forms of cognitive impairment, with one of the most common behavioral abnormalities to manifest being motor dysfunction. This is an important consideration, as deficits in motor control likely contribute to higher-order cognitive impairments, which together, lead to functional dependencies in the ever-growing aging population of HIV-infected adults. While the neuroanatomical bases of motor dysfunction have recently been illuminated in people living with HIV (PLWH), there remains an open question regarding the molecular processes supporting the circuit-level neuronal dynamics that potentially serve these behavioral …
The Driving Simulator Visual Field In Glaucoma – A Novel Task To Test Available Field Of View, Deepta Ghate
The Driving Simulator Visual Field In Glaucoma – A Novel Task To Test Available Field Of View, Deepta Ghate
Theses & Dissertations
Glaucoma causes peripheral vision loss and impaired driving performance. We developed a novel driving simulator visual field task (DSVF) in a panoramic driving simulator to map the available field of view under different perceptual task loads in naturalistic settings. Our hypothesis is that “available field of view” will decrease with increasing task load in both glaucoma subjects and controls. This is a cross-sectional study with 28 glaucoma subjects and 19 controls. DSVF (60̊ x 20̊ visual field at 2.5 m) was tested in a high-fidelity interactive driving simulator in 4 different scenarios: a) no distractions b) no driving condition with …
The Effect Of Obstacle Intervals On Foot Integrated Pressure And Obstacle Negotiation Strategy, Zhuo Wang
The Effect Of Obstacle Intervals On Foot Integrated Pressure And Obstacle Negotiation Strategy, Zhuo Wang
Theses & Dissertations
When stepping over a single obstacle, despite of some spatiotemporal parameter changes, the impulse of the leading and trailing leg stays the same. This is considered an efficient obstacle avoidance strategy. However, research has shown that the strategy of multiple obstacles negotiation is different from a single obstacle crossing. Would this efficient strategy still exist during multiple obstacles negotiation? This study attempted to answer this question. Nineteen healthy young adults were recruited in this study. Each participant was required to complete 15 trials under 3 conditions: one-step, two-step, and three-step intervals. Data were collected for foot integrated pressure (FIP), walking …
Reach, Effectiveness, Adoption, And Maintenance Of Mobile Electronic Clinical Decision Support Tools Deployed As Part Of National Quality Improvement Projects, Ellen K. Kerns
Theses & Dissertations
Electronic clinical decision support (ECDS) tools are often developed within quality improvement (QI) projects to increase adherence with the latest clinical practice guidelines. However, the potential reach and maintenance of ECDS use beyond the time and location of their associated project are very limited. Deploying ECDS using a mobile app (mECDS) has shown the potential to be a viable method of overcoming these limitations. However, it is unclear what pattern the reach and adoption of such a tool might follow and what effect this use has on clinical practice. Our team developed an app which contained two different mECDS tools …
Is The Walking Pattern Similar Between Slope Walking And Obstacle Negotiation?, Jiani Lu
Is The Walking Pattern Similar Between Slope Walking And Obstacle Negotiation?, Jiani Lu
Theses & Dissertations
Studying biomechanical characteristics of human motion sheds light on the motor control strategies in the central nervous system. Slope walking and obstacle negotiation appear to have some similarities in control strategies based on subjective observation, but these two motions have never been compared objectively in biomechanics literature. This study aimed to investigate the similarities between obstacle negotiation and slope walking in kinematics and muscle activity. The similarities were determined by the correlation of the maximum heel elevation and muscle co-activation index between obstacle negotiation and inclined treadmill walking. The strength of correlation was compared in four different pairs of conditions: …
The Role Of Vgll4 And Mark2-Hdac Axis In Mitosis And Cancer, Yongji Zeng
The Role Of Vgll4 And Mark2-Hdac Axis In Mitosis And Cancer, Yongji Zeng
Theses & Dissertations
The Hippo pathway is an evolutionarily conserved signaling pathway that plays important roles in stem cell biology, tissue homeostasis, and cancer development. The Hippo core signaling pathway features a kinase cascade consisting of mammalian sterile-20 like protein 1/2 (Mst1/2) and large tumor suppressor 1/2 (Lats1/2). Inactivation of the Hippo pathway is correlated with the promotion of proliferation and anti-apoptosis through activation of the transcriptional co-activator Yes-associated protein (YAP). YAP functions through binding with TEA-domain transcription factors (TEAD1–4) to activate target genes.
Vestigial-like 4 (Vgll4) functions as a transcriptional co-repressor in the Hippo-Yes associated protein (YAP) pathway. Vgll4 inhibits cell proliferation …