Medicine and Health Sciences Commons^™

2021-05-24_Michiganoverview_Covidschooloutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The School Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_102480---,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

In accordance with the Council of State and Territorial Epidemiologists’ outbreak definition, schools that have been found by their local health department to have two (2) or more COVID-19 cases who may have shared exposure at the school grounds and are not from the same household (with the exception of dorms and off-campus housing) are included. If your child’s school is …

2021-05-24_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Mental Health And The Impact Of Friendship, Ian Adkins

WRIT: Journal of First-Year Writing

Mental health issues are a very large problem in the United States today. For a long time, mental health issues were ignored and not even seen as something worth looking into or studying, let alone being a real medical condition. When they finally started to come to light, they were only associated with adults. In the United States, children’s mental health issues were largely ignored. It has only been recently that mental health in adolescents is being addressed, and phycologist and scientists are finding important information about how friendships can impact the way these at-risk adolescents deal with mental health …

Efforts Toward Novel Methods For The Synthesis Of Stereochemically-Dense Pharmacologically Relevant Scaffolds, Lauren Nicole Tumbelty

Theses and Dissertations

Nitrogen is the most common pure element, present in nearly all relevant chemical compounds. It is an essential component of the building blocks of life such as proteins, nucleic acids, amino acids and adenosine tri-phosphate. There is a naturally occurring exchange between living organisms and the atmosphere which begins with the process of fixation. Although nitrogen is naturally abundant, the strength of the triple bond in atmospheric nitrogen prevents its applicability in organic synthesis. Therefore, the development of methods to place synthetic nitrogen into heteroatomic compounds plays an important role in the development of pharmacologically relevant scaffolds. Contained within this …

Developing A Practical Application Of The Isometric Squat And Surface Electromyography, David Phillips, Angelic Rose Del Vecchio, Kevin Carroll, Evan L. Matthews

Department of Exercise Science and Physical Education Scholarship and Creative Works

Electromyography (EMG) is a research tool used in gait analysis, muscle coordination evaluation, clinical evaluation and sports techniques. Electromyography can provide an insight into neural adaptations, cross education effects, bilateral contraction deficiencies, and antagonist activity in exercise-related movements. While there are clear benefits to using EMG in exercise-related professions, accessibility, cost, and difficulty interpreting the data limit its use in strength and clinical settings. We propose a practical EMG assessment using the isometric squat to identify compensatory activation patterns and report early observations. Ten healthy participants were recruited. Participants performed a 2-min isometric handgrip protocol and an isometric squat protocol. …

Commecement, Philadelphia (2021), Philadelphia College Of Osteopathic Medicine

Commencements

Philadelphia Campus D.O. Commencement program, Class of 2021. Degrees include Doctorate in Osteopathic Medicine.

Intravitreal Gene Therapy Vs. Natural History In Patients With Leber Hereditary Optic Neuropathy Carrying The M.11778g>A Nd4 Mutation: Systematic Review And Indirect Comparison, Nancy J. Newman, Patrick Yu-Wai-Man, Valerio Carelli, Valerie Biousse, Mark Moster, Catherine Vignal-Clermont, Robert C. Sergott, Thomas Klopstock, Alfredo A. Sadun, Jean-François Girmens, Chiara La Morgia, Adam A. Debusk, Neringa Jurkute, Claudia Priglinger, Rustum Karanjia, Constant Josse, Julie Salzmann, François Montestruc, Michel Roux, Magali Taiel, José-Alain Sahel

Wills Eye Hospital Papers

Objective: This work aimed to compare the evolution of visual outcomes in Leber hereditary optic neuropathy (LHON) patients treated with intravitreal gene therapy to the spontaneous evolution in prior natural history (NH) studies.

Design: A combined analysis of two phase three randomized, double-masked, sham-controlled studies (REVERSE and RESCUE) and their joint long-term extension trial (CLIN06) evaluated the efficacy of rAAV2/2-ND4 vs. 11 pooled NH studies used as an external control.

Subjects: The LHON subjects carried the m.11778G>A ND4 mutation and were aged ≥15 years at onset of vision loss.

Methods: A total of 76 subjects received a single …

Glun2d Nmda Receptors Gate Fear Extinction Learning And Interneuron Plasticity, Christophe J. Dubois, Siqiong June Liu

School of Medicine Faculty Publications

The cerebellum is critically involved in the formation of associative fear memory and in subsequent extinction learning. Fear conditioning is associated with a long-term potentiation at both excitatory and inhibitory synapses onto Purkinje cells. We therefore tested whether fear conditioning unmasks novel forms of synaptic plasticity, which enable subsequent extinction learning to reset cerebellar circuitry. We found that fear learning enhanced GABA release from molecular layer interneurons and this was reversed after fear extinction learning. Importantly an extinction-like stimulation of parallel fibers after fear learning is sufficient to induce a lasting decrease in inhibitory transmission (I-LTDstim) in the cerebellar cortex, …

Evaluation Of Potential Exposure Risks From 3d Printing Operations Using Niosh Evade Software, Cheri Marcham, Rustin Reed

Publications

Presentation discusses the following research objectives:

1. Address student workers’ concern regarding respiratory health

2. Characterize aerosol and VOC exposures during printing operations

3. Identify primary sources of exposure using NIOSH EVADE software, spatial analysis

Week Of May 24, 2021, New York Medical College

InTouch

• NYMC Names Tracey A. Milligan, M.D., Chair of Neurology
• NYMC Faculty Honored as Healthcare Heroes
• NYMC Hosts Paul K. Woolf, M.D., Pediatric Trainee Research Day
• Chancellor Halperin Addresses Death by Firing Squad as a Form of Execution

From Managing Nurses To Serving Nurses: The Case For Transfusing Nursing Management With Servant Leadership During The Global Covid-19 Pandemic, William P. Jimenez, Seterra D. Burleson, Matthew J. Haugh

Psychology Faculty Publications

No abstract provided.

Arterial Dissection In Antiphospholipid Syndrome Patients: Two Case Reports And A Literature Review, Kadhim Al-Banaa, Alfarooq Alshaikhli, Asal Al-Hareeri, Mohammed Abdelhalim, Alsadiq Al-Hillan, Tejas Joshi

School of Medicine Publications

Antiphospholipid syndrome (APS) is a multisystemic autoimmune disease which presents with thromboembolic disease, pregnancy complications and the presence of antiphospholipid antibodies. There are some reports of arterial dissections in different sites of the body associated with APS. We describe two patients with APS who developed ischaemic stroke as a result of vertebral artery dissection in the absence of acquired and genetic risk factors for arterial dissection. We also conducted a systematic review of the literature for cases of arterial dissection associated with APS. We suspect that APS may be a potential cause of vasculopathy and arterial dissection. Further research is …

2021-05-23_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Examining The Efficacy Of Providing Writing Prompt Choices And Performance Feedback: A Randomized Controlled Trial, Josh Circe

Theses - ALL

Research has indicated that the majority of students in the United States are not able to write at the proficient level (Persky et al., 2003). Prior research has demonstrated that performance feedback interventions successfully lead to students' gains in writing fluency (Hier & Eckert, 2014; Hier & Eckert, 2016; Truckenmiller et al., 2014), and that providing students with academic choices benefits their academic performance (Dickerson & Creedon, 1981; Steinman 2017). The goal of this study was to examine the combined and isolated effects of two academic interventions (i.e., providing writing prompt choices and performance feedback) on third-grade students' writing performance. …

Reflections From The In-Between: Visualizing The Mental Thresholds Of Dissociation, Katherine Virag

Theses - ALL

I am fascinated by the state of being in-between; by the mental spaces that are somehow neither here nor there, but also somehow both here and there. At a young age, I began to experience depersonalization and derealization, and this dissociated state left me feeling trapped somewhere on the threshold of reality and non-reality. My artistic practice is concerned with the psychological antitheses of dissociation – comfort vs discomfort, safety vs danger, and reality vs non-reality, and the continuum of space between these polarities. Often through large-scale installations, I create a physical space for the viewer to enter. These spaces, …

The Influence Of Self-Compassion On Perceived Stress Reactivity, Emily C. Helminen

Theses - ALL

Contemplative psychological traits (e.g., mindfulness and self-compassion) have become a popular area of research in recent years, often in the context of their influence on stress (Creswell & Lindsay, 2014). One promising subset of contemplative science research demonstrates that higher levels of contemplative traits are associated with decreased physiological stress reactivity during psychosocial stress induction. This is important due to the negative health outcomes that are associated with persistently heightened stress reactivity. Research investigating self-compassion has demonstrated that higher levels of trait self-compassion are associated with lower levels of stress reactivity (Breines et al., 2015; Luo et al., 2018). Currently, …

Pluralistic Ignorance Of Attitudes Toward Mental Health Services Among College Students, Rikki Hope Sargent

Dissertations - ALL

Students underutilize mental health services on college campuses in the United States. More research is needed to fully understand barriers to service use among this at-risk population and interventions should be created to address these barriers. Current research and interventions do not address group-level social comparison processes that elevate lack of service use. Particularly, pluralistic ignorance has not been assessed—that is, the systematic misperception of others' cognitions and behaviors within a social group. It is possible that pluralistic ignorance contributes to the underutilization of services on college campuses. I began this assessment in three studies. In Study 1 (N = …

Family History Of Alcohol Use Disorder As A Predictor Of Endogenous Pain Modulatory Function, Kyle Mackenzie White

Theses - ALL

Family history of alcohol use disorder (AUD) is frequently endorsed by chronic pain patients. Although individuals with a family history of AUD have demonstrated enhanced sensitivity to painful stimulation, we are not aware of any previous research that has examined clinically-relevant endogenous pain modulation (i.e., capacity to inhibit or facilitate pain) in this population. The goal of this study was to test family history of AUD as a predictor of conditioned pain modulation, offset analgesia, and temporal summation among a sample of moderate-to-heavy drinkers. Participants (N = 235; 58.3% male; Mage = 34.3, SD = 12.3) were evaluated for family …

Complexity Of Malaria Transmission Dynamics In The Brazilian Atlantic Forest, Ana Maria Ribeiro De Castro Duarte, Licia Natal Fernandes, Fabiana Santos Silva, Igor Lucoves Sicchi, Luis Filipe Mucci, Izilda Curado, Aristides Ferrnandes, Antônio Ralph Medeiros-Sousa, Walter Ceretti-Junior, Mauro Toledo Marrelli, Eduardo Evangelista, Renildo Teixeira, Juliana Laurito Summa, Marcello Schiavo Nardi, Margoth Ramos Garnica, Ana Carolina Loss, Julyana Cerqueira Buery, Crispim Cerutti Jr., M. Andreína Pacheco, Ananias A. Escalante, Maria Anice Mureb Sallum, Gabriel Zorello Laporta

Harold W. Manter Laboratory of Parasitology: Library Materials

Plasmodium malariae and Plasmodium vivax are protozoan parasites that can cause malaria in humans. They are genetically indistinguishable from, respectively, Plasmodium brasilianum and Plasmodium simium, that is, parasites infecting New World non-human primates in South America. In the tropical rainforests of the Brazilian Atlantic coast, it has long been hypothesized that P. brasilianum and P. simium in platyrrhine primates originated from P. malariae and P. vivax in humans. A recent hypothesis proposed the inclusion of Plasmodium falciparum into the transmission dynamics between humans and non-human primates in the Brazilian Atlantic tropical rainforest. Herein, we assess the occurrence of human …

Preparing Historically Underrepresented Trainees For Biomedical Cancer Research Careers At Huntsman Cancer Institute/University Of Utah Health., Ana Maria Lopez, Md, Mph, Macp, José E Rodríguez, Kathryn Browning Hawes, Anna Marsden, Don Ayer, Donna Harp Ziegenfuss, Kola Okuyemi

Department of Medical Oncology Faculty Papers

Given the well-documented inequities in health care outcomes by race, ethnicity, and gender, many health career pipeline programs have focused on supporting the development of a diverse and inclusive workforce. The State of Utah, is vast, but sparsely populated outside the Salt Lake City metropolitan area. More than 96% of our nearly 85,000 square miles is designated rural (<100 people/square mile) or frontier (<7 people/square mile). The Salt Lake City area is home to the Hunsman Cancer Institute, the only NCI-designated Comprehensive Cancer Center in the region, also noted the limited diversity in the biomedical cancer research workforce. Our primary objective was to increase the number of underrepresented trainees who pursue higher education with the goal of a career in cancer research. PathMaker is a regional, competitive pipeline program that nurtures high school or undergraduate trainees from historically underrepresented backgrounds towards a career in cancer research. Our faculty and staff team collaboratively developed a cohort model curriculum that increased student awareness of research …

The Impact Of Poverty And Neighborhood Characterstics On The Mental Health And Parent-Child Closeness In The Black Community: The Protective Role Of Black Cultural Strengths, Brandon Davis Hollie

Dissertations - ALL

Poverty and negative neighborhood characteristics can be detrimental to the mental health wellbeing of Black people. Yet, there is a lack of understanding of how, why, and for whom such factors impact the mental of the Black community. Using a sample of 1654 Black families from the Fragile Family and Child Wellbeing Study I investigated two models. First, I examined the path from poverty to depression, anxiety, and tested Black cultural strengths, religiosity and neighborhood cohesion as moderators. Second, I examined the path from poverty to parent-child closeness and tested Black cultural strengths, social ties and extended family as moderators. …

Novel Autosegmentation Spatial Similarity Metrics Capture The Time Required To Correct Segmentations Better Than Traditional Metrics In A Thoracic Cavity Segmentation Workflow, Kendall J Kiser, Arko Barman, Sonja Stieb, Clifton D Fuller, Luca Giancardo

2020-Current year OA Pubs

Automated segmentation templates can save clinicians time compared to de novo segmentation but may still take substantial time to review and correct. It has not been thoroughly investigated which automated segmentation-corrected segmentation similarity metrics best predict clinician correction time. Bilateral thoracic cavity volumes in 329 CT scans were segmented by a UNet-inspired deep learning segmentation tool and subsequently corrected by a fourth-year medical student. Eight spatial similarity metrics were calculated between the automated and corrected segmentations and associated with correction times using Spearman's rank correlation coefficients. Nine clinical variables were also associated with metrics and correction times using Spearman's rank …

Challenges For Children And Adolescents With Autism And Their Families During The Covid-19 Pandemic, Orsolya Pachner, Gabor Aranyi

Journal of Global Awareness

The restrictions and lockdown measures implemented in response to the Covid-19 pandemic have posed a pronounced risk to the mental health of people with autism and their families. We discuss specific difficulties affecting children and adolescents with autism and their families during the pandemic, drawing on a broad range of recently published research in many countries and regions. A global perspective is adopted to provide an overview of the state of affairs and identify good practices. We consider challenges in four areas: research and practice related to autism, challenges facing children and adolescents with autism, specific difficulties in their education …

Global Journey To Post-Pandemic Normalcy And Revival, Andrzej Sankowski

Journal of Global Awareness

After a year of COVID-19, countries, societies, and individuals are longing for normalcy and beginning to consider what life will be like post-pandemic. Efforts and experiences of countries in the European Union, Asia, Asia-Pacific, Australia, Africa, Latin America, the Caribbean, and the United States are examined as they face challenges to end the pandemic and prepare for the post-pandemic reality. What will be the post-pandemic "new normalcy"? What changes caused by the pandemic are permanent in societies and the world? What are the necessary reforms that have to take place as part of normalcy? Reflections on the impacts of vaccinations, …

Evaluation Of Multi-Level Barriers And Facilitators In A Large Diabetic Retinopathy Screening Program In Federally Qualified Health Centers: A Qualitative Study, Ana Bastos De Carvalho, S. Lee Ware, Tamara Belcher, Franceska Mehmeti, Eric B. Higgins, Robert Sprang, Cody Williams, Jamie L. Studts, Christina R. Studts

Ophthalmology and Visual Science Faculty Publications

BACKGROUND: Recommended annual diabetic retinopathy (DR) screening for people with diabetes has low rates in the USA, especially in underserved populations. Telemedicine DR screening (TDRS) in primary care clinics could expand access and increase adherence. Despite this potential, studies have observed high variability in TDRS rates among clinics and over time, highlighting the need for implementation supports. Previous studies of determinants of TDRS focus on patients' perspectives, with few studies targeting upstream multi-level barriers and facilitators. Addressing this gap, this qualitative study aimed to identify and evaluate multi-level perceived determinants of TDRS in Federally Qualified Health Centers (FQHCs), to inform …

Reprogramming Oral Epithelial Keratinocytes Into A Pluripotent Phenotype For Tissue Regeneration, Fayrouz Bazina, Sabine M. Brouxhon, Stephanos Kyrkanides

Center for Oral Health Research Faculty Publications

OBJECTIVES: We set out to reprogram adult somatic oral epithelial keratinocytes into pluripotent cells for regenerative dentistry.

SETTING AND SAMPLE POPULATION: Immortalized murine oral keratinocyte cell (IMOK) line raised from adult mouse mucosa were cultured in vitro in our studies.

MATERIALS AND METHODS: Adult murine oral epithelial keratinocytes were chronically treated with TGF-β1 in vitro, and the expression of Oct4, Nanog, Sox2 and Nestin, as well as specific homeobox Gata and Pax gene family members were investigated.

RESULTS: We documented the induction of stem factors linked with pluripotency and/or the maintenance and regulation of stem-cell self-renewal in oral epithelial keratinocytes …

2021-05-22_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2021-05-22_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Monday - Saturday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …

Gender, Sexuality And Human Rights: A Comparative Analysis Of The Role Of Civil Society Organizations In Hiv/Aids Responses In Brazil And Nigeria, Emma Stefania Schoppmeyer

Senior Theses

A global epidemic that has affected lives around the world, AIDS has accentuated inequalities across class, race, gender and sexual orientation. In many developing countries, women are disproportionately affected by the epidemic and are more vulnerable than men to HIV infection. The objective of this paper is to address the cultural and social norms surrounding gender and sexuality that have allowed and perpetuated women’s susceptibility to AIDS. I examine the gender constructs and inequities in Brazil and Nigeria to demonstrate how gender affects transmission in sexual relationships as well as the role it plays in creating differential experiences with HIV …

"The Use Of Water As A Weapon Against Public Health In Palestine And Kashmir", Evan D. Gumas

Senior Theses

Water as a political tool has serious implications for global conflicts and its very nature has devastating impacts on public health. No disputes display these more clearly than those in Palestine and Kashmir which are, in large part, water related. Subsequently, public health is affected as water is integral to public health. Both Palestine and Kashmir’s positions in their regions of the world make their experiences with water weaponization against public health unique, but their statuses as occupied territories share vast similarities which make them perfect candidates for research on the intersection of water use as a weapon and public …