Medicine and Health Sciences Commons^™

Lesion Loci Of Impaired Affective Prosody: A Systematic Review Of Evidence From Stroke, Alexandra Zezinka Durfee, Shannon M. Sheppard, Margaret L. Blake, Argye E. Hillis

Communication Sciences and Disorders Faculty Articles and Research

Affective prosody, or the changes in rate, rhythm, pitch, and loudness that convey emotion, has long been implicated as a function of the right hemisphere (RH), yet there is a dearth of literature identifying the specific neural regions associated with its processing. The current systematic review aimed to evaluate the evidence on affective prosody localization in the RH. One hundred and ninety articles from 1970 to February 2020 investigating affective prosody comprehension and production in patients with focal brain damage were identified via database searches. Eleven articles met inclusion criteria, passed quality reviews, and were analyzed for affective prosody localization. …

Landscape-Based Mutational Sensitivity Cartography And Network Community Analysis Of The Sars-Cov-2 Spike Protein Structures: Quantifying Functional Effects Of The Circulating D614g Variant, Gennady M. Verkhivker, Steve Agajanian, Deniz Yasar Oztas, Grace Gupta

Mathematics, Physics, and Computer Science Faculty Articles and Research

We developed and applied a computational approach to simulate functional effects of the global circulating mutation D614G of the SARS-CoV-2 spike protein. All-atom molecular dynamics simulations are combined with deep mutational scanning and analysis of the residue interaction networks to investigate conformational landscapes and energetics of the SARS-CoV-2 spike proteins in different functional states of the D614G mutant. The results of conformational dynamics and analysis of collective motions demonstrated that the D614 site plays a key regulatory role in governing functional transitions between open and closed states. Using mutational scanning and sensitivity analysis of protein residues, we identified the stability …

College Of Health Professions News, Georgia Southern University

College of Health Professions: News & Publications (2012-2023)

• Students Participate in Interprofessional Grand Rounds

Quality Assessment Of Published Systematic Reviews In High Impact Cardiology Journals: Revisiting The Evidence Pyramid, Abdelrahman Abushouk, Ismaeel Yunusa Ph.D., Abdelmagid M. Elmatboly, Shady Fayek, Omar M. Abdelfattah, Anas Saad, Isogai Toshiaki, Shashank Shekhar, Ankur Kalra, Grant W. Reed, Rishi Puri, Samir Kapadia

Faculty Publications

Objective: Systematic reviews are increasingly used as sources of evidence in clinical cardiology guidelines. In the present study, we aimed to assess the quality of published systematic reviews in high impact cardiology journals.

Methods: We searched PubMed for systematic reviews published between 2010 and 2019 in five general cardiology journals with the highest impact factor (according to Clarivate Analytics 2019). We extracted data on eligibility criteria, methodological characteristics, bias assessments, and sources of funding. Further, we assessed the quality of retrieved reviews using the AMSTAR tool.

Results: A total of 352 systematic reviews were assessed. The AMSTAR quality score was …

Postsecondary Educational Attainment And Health Among Younger U.S. Adults In The “College-For-All” Era, Anna Zajacova, Elizabeth Lawrence

Sociology Faculty Research

Population-health research has neglected differentiation within postsecondary educational attainments. This gap is critical to understanding health inequality because college experience with no degree, vocational/technical certificates, and associate degrees may affect health differently. We examine health across detailed postsecondary attainment levels. We analyze data on 14,750 respondents in Waves I and IV of the nationally representative Add Health panel spanning adolescence to ages 26 to 34. Multivariate regression and counterfactual approaches to minimize the impact of confounders estimate multiple health outcomes across postsecondary attainment levels. Compared to high school diplomas, we find significant returns to bachelor’s degrees for most health outcomes …

Propensity Score Analysis Assessing The Burden Of Non-Communicable Diseases Among The Transgender Population In The United States Using The Behavioral Risk Factor Surveillance System (2017–2019), Jennifer R. Pharr, Kavita Batra

Environmental & Global Health Faculty Research

Research to assess the burden of non-communicable diseases (NCDs) among the transgender population needs to be prioritized given the high prevalence of chronic conditions and associated risk factors in this group. Previous cross-sectional studies utilized unmatched samples with a significant covariate imbalance resulting in a selection bias. Therefore, this cross-sectional study attempts to assess and compare the burden of NCDs among propensity score-matched transgender and cisgender population groups. This study analyzed Behavioral Risk Factor Surveillance System data (2017–2019) using complex weighting procedures to generate nationally representative samples. Logistic regression was fit to estimate propensity scores. Transgender and cisgender groups were …

Variant-Specific Inflation Factors For Assessing Population Stratification At The Phenotypic Variance Level, Tamar Sofer, Xiuwen Zheng, Cecelia A Laurie, Stephanie M Gogarten, Jennifer A Brody, Matthew P Conomos, Joshua C Bis, Timothy A Thornton, Adam Szpiro, Jeffrey R O'Connell, Ethan M Lange, Yan Gao, L Adrienne Cupples, Bruce M Psaty, Kenneth M Rice

Faculty, Staff and Student Publications

In modern Whole Genome Sequencing (WGS) epidemiological studies, participant-level data from multiple studies are often pooled and results are obtained from a single analysis. We consider the impact of differential phenotype variances by study, which we term 'variance stratification'. Unaccounted for, variance stratification can lead to both decreased statistical power, and increased false positives rates, depending on how allele frequencies, sample sizes, and phenotypic variances vary across the studies that are pooled. We develop a procedure to compute variant-specific inflation factors, and show how it can be used for diagnosis of genetic association analyses on pooled individual level data from …

Scientific Mapping Of Research On Digital Pulmonary Function Test: A Bibliometric Analysis, Aditya Kekre Mr., Ashutosh Desai Mr., Ashwin Sujit Mr., Dhruv Dewett Mr., Shilpa Hudnurkar Prof.

Library Philosophy and Practice (e-journal)

Digital Pulmonary Function Test (PFT) is a non-invasive test that helps in evaluating the efficiency of a patient’s lungs. The test is key to keeping tabs on a patient’s health that may be suffering from Chronic Obstructive Pulmonary Disease, Asthma, Restrictive Respiratory Disease, etc, as pollution increases day by day in the world the amount of people getting affected from it and being diagnosed with respiratory diseases the importance of PFT continues to grow. The Scopus database has been used exclusively for this analysis. A key observation of this survey has been that engineering and medicine have gone hand in …

Impact Of Neoantigen Expression And T-Cell Activation On Breast Cancer Survival, Wenjing Li, Amei Amei, Francis Bui, Saba Norouzifar, Lingeng Lu, Zuoheng Wang

Mathematical Sciences Faculty Research

Neoantigens are derived from tumor-specific somatic mutations. Neoantigen-based syn-thesized peptides have been under clinical investigation to boost cancer immunotherapy efficacy. The promising results prompt us to further elucidate the effect of neoantigen expression on patient survival in breast cancer. We applied Kaplan–Meier survival and multivariable Cox regression models to evaluate the effect of neoantigen expression and its interaction with T-cell activation on overall survival in a cohort of 729 breast cancer patients. Pearson’s chi-squared tests were used to assess the relationships between neoantigen expression and clinical pathological variables. Spearman correlation analysis was conducted to identify correlations between neoantigen expression, mutation …

Prevalence And Risk Factors Associated With Multi-Drug Resistant Organisms (Mdro) Carriage Among Pediatric Patients At The Time Of Admission In A Tertiary Care Hospital Of A Developing Country. A Cross-Sectional Study, Sonia Qureshi, Noshi Maria, Mohammad Zeeshan, Seema Irfan, Farah Naz Qamar

Department of Paediatrics and Child Health

Background: The rise of Multidrug-resistant organisms (MDROs) poses a considerable burden on the healthcare systems, particularly in low-middle income countries like Pakistan. There is a scarcity of data on the carriage of MDRO particularly in the pediatrics population therefore, we aimed to determine MDRO carriage in pediatric patients at the time of admission to a tertiary care hospital in Karachi, Pakistan, and to identify the risk factors associated with it.
Methods: A cross-sectional study conducted at the pediatric department of Aga Khan University Hospital (AKUH) from May to September 2019 on 347 children aged 1-18 years. For identification of MDRO …

College Of Public Health News, Georgia Southern University

College of Health Professions: News & Publications (2012-2023)

• Students Participate in Interprofessional Grand Rounds

Rehabilitation Sciences News, Georgia Southern University

Clinical Sciences: News & Publications (2018-2023)

• Graduate Students Provide Communication Disorders Training

Covid-19 Pandemic Awareness, Attitudes, And Practices Among The Pakistani General Public, Rehana Rehman, Shireen Jawed, Rabiya Ali, Khola Noreen, Mukhtiar Baig, Javaria Baig

Department of Biological & Biomedical Sciences

Background: Outbreak of COVID-19, in many countries, has imposed a lockdown on their residents. The usefulness of extenuative actions is extremely reliant on society's knowledge, attitudes, and practices (KAP) toward pandemic control.
Objective: This study aimed to explore the awareness, attitudes, and practices of the general Pakistani population to COVID-19.
Methods: From June 13, 2020, until June 30, 2020, a cross-sectional online KAP survey was conducted among the Pakistani public. For data collection, a validated self-administered questionnaire was used. The survey instrument consisted of six demographic characteristics, 14 items on knowledge, four on attitudes, and six items on practices, modified …

Inferring Tf Activities And Activity Regulators From Gene Expression Data With Constraints From Tf Perturbation Data, Cynthia Z Ma, Michael R Brent

2020-Current year OA Pubs

MOTIVATION: The activity of a transcription factor (TF) in a sample of cells is the extent to which it is exerting its regulatory potential. Many methods of inferring TF activity from gene expression data have been described, but due to the lack of appropriate large-scale datasets, systematic and objective validation has not been possible until now.

RESULTS: We systematically evaluate and optimize the approach to TF activity inference in which a gene expression matrix is factored into a condition-independent matrix of control strengths and a condition-dependent matrix of TF activity levels. We find that expression data in which the activities …

An Examination Of Covid-19 Health Behaviors And Public Health Messaging Using The Health Belief Model And Organization-Public Relationship Quality, Aaron L. Nichols

USF Tampa Graduate Theses and Dissertations

In the context of the most severe pandemic in over 100 years, this study examined public health behavior and public health messaging using the health belief model (HBM) and organization-public relationships (OPR) as frameworks. The study employed a cross-sectional survey of students (N = 288) and employees (N = 203) at a large public university in the southeastern United States. First, the study empirically tested the components of the HBM as determinants of engaging in public health behaviors meant to slow or prevent the spread of COVID-19 and found all components of the model to be significantly related to engaging …

4-1bbl As A Mediator Of Cross-Talk Between Innate, Adaptive, And Regulatory Immunity Against Cancer, Alejandra G. Martinez-Perez, Jose J. Perez-Trujillo, Rodolfo Garza-Morales, Maria J. Loera-Arias, Odila Saucedo-Cardenas, Aracely Garcia-Garcia, Humberto Rodriguez-Rocha, Roberto Montes-De-Oca-Luna

School of Medicine Publications

The ability of tumor cells to evade the immune system is one of the main challenges we confront in the fight against cancer. Multiple strategies have been developed to counteract this situation, including the use of immunostimulant molecules that play a key role in the anti-tumor immune response. Such a response needs to be tumor-specific to cause as little damage as possible to healthy cells and also to track and eliminate disseminated tumor cells. Therefore, the combination of immunostimulant molecules and tumor-associated antigens has been implemented as an antitumor therapy strategy to eliminate the main obstacles confronted in conventional therapies. …

Determinants Of Penetrance And Variable Expressivity In Monogenic Metabolic Conditions Across 77,184 Exomes, Julia K. Goodrich, Moriel Singer-Berk, Rachel Son, Abigail Sveden, Jordan Wood, Eleina England, Joanne B. Cole, John Blangero, Ben Weisburd, Ravi Duggirala

School of Medicine Publications

Hundreds of thousands of genetic variants have been reported to cause severe monogenic diseases, but the probability that a variant carrier develops the disease (termed penetrance) is unknown for virtually all of them. Additionally, the clinical utility of common polygenetic variation remains uncertain. Using exome sequencing from 77,184 adult individuals (38,618 multi-ancestral individuals from a type 2 diabetes case-control study and 38,566 participants from the UK Biobank, for whom genotype array data were also available), we apply clinical standard-of-care gene variant curation for eight monogenic metabolic conditions. Rare variants causing monogenic diabetes and dyslipidemias display effect sizes significantly larger than …

Optimization Of The Training Process Through The Targeted Use Of Specific Physical Exercises, Guzal Andreevna Seyjanova

Eurasian Journal of Sport Science

Purpose: The purpose of this study is to improve the special motor abilities of gymnasts aged 13-14 years in group exercises based on the distribution of special physical exercises in the preparatory period .

Methods: 1. Pedagogical observations. 2. Pedagogical control tests. 3. Pedagogical experiment. 4. Mathematical and statistical analysis.

Results: In the course of the experimental group of gymnasts significantly increased: -the level of special-physical readiness by 14.8%; - technical readiness according to the results of expert assessment-from 0.46 to 0.72 points; average risk assessments in the composition by 0.9 points; the results of competitive assessments increased by 1.24 …

2021-06-08_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2021-06-08_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2021-06-08_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-526911--,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The information below represents COVID-19 data reported directly to MDHHS by licensed and operating Skilled Nursing, Home for the Aged and Adult Foster Care facilities (licensed to serve 13 or more individuals) in Michigan from January 1, 2020. All long-term care facilities additionally have an obligation to report COVID-positive residents and/or staff …

Induction Of Stress-Induced Renal Cellular Senescence In Vitro: Impact Of Mouse Strain Genetic Diversity., Chieh Ming Liao, Vera Christine Wulfmeyer, Maxine Swallow, Christine Susanne Falk, Hermann Haller, Ron Korstanje, Anette Melk, Roland Schmitt

Faculty Research 2021

Cellular senescence, a stress-induced state of irreversible cell cycle arrest, is associated with organ dysfunction and age-related disease. While immortalized cell lines bypass key pathways of senescence, important mechanisms of cellular senescence can be studied in primary cells. Primary tubular epithelial cells (PTEC) derived from mouse kidney are highly susceptible to develop cellular senescence, providing a valuable tool for studying such mechanisms. Here, we tested whether genetic differences between mouse inbred strains have an impact on the development of stress-induced cellular senescence in cultured PTEC. Kidneys from 129S1, B6, NOD, NZO, CAST, and WSB mice were used to isolate PTEC. …

Intracranial Mycoplasma Hominis Infection Following Emergent Craniectomy, Zahra Qamar, Stavropoula Tjoumakaris, Matthew Pattengill, Maliha Ahmed, Bryan Hess

Division of Infectious Diseases and Environmental Medicine Faculty Papers

We present a case of a young healthy female who developed recurrent cranial wound infections after a traumatic injury, the etiologic organism finally identified as Mycoplasma hominis, an uncommon and difficult to isolate bacterium.

2021-06-08_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Monday - Saturday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …

Emergency Use Of Targeted Osmotic Lysis For The Treatment Of A Patient With Aggressive Late-Stage Squamous Cell Carcinoma Of The Cervix, Harry J. Gould, Paige R. Miller, Samantha Edenfield, Kelly Jean Sherman, Chad K. Brady, Dennis Paul

School of Medicine Faculty Publications

Upregulation of voltage-gated sodium channels (VGSCs) and Na+/K+-ATPase (sodium pumps) is common across most malignant carcinomas. Targeted osmotic lysis (TOL) is a developing technology in which the concomitant stimulation of VGSCs and pharmacological blockade of sodium pumps causes rapid selective osmotic lysis of carcinoma cells. This treatment of cervical carcinoma is evidence that TOL is a safe, well-tolerated and effective treatment for aggressive advanced carcinomas that has the potential to extend life without compromising its quality. TOL is likely to have broad application for the treatment of advanced-stage carcinomas.

Qualitative Exploration Of Mealtime Routines And Parental Stress Of Children With Pediatric Feeding Disorders: Analysis Of Occupational Performance, Andrea Patino

Student Capstone Papers

Pediatric feeding disorders (PFD) affect approximately 25-35% of children with typical development, 40-80% of children with developmental disabilities, and 90% of children with autism spectrum disorder (ASD). Feeding disorders affect families by disrupting mealtime routines, changing family dynamics, and increasing parental stress. Occupational therapy (OT) focuses on client-centered care that facilitates independence in meaningful occupations, including feeding and eating. OTs also play an essential role in assisting, training, and educating parents on effective mealtime strategies that can be implemented and carried over into the home environment. Few research studies show how parents manage behaviors and stress during mealtime routines, and …

Analysis Of Occupational Therapy’S Role To Promote Healthy Sleep Participation To Support Caregivers Of Children With Autism Spectrum Disorder, Sophia N. Roman

Student Capstone Papers

Children with autism spectrum disorder (ASD) face sleep disturbances. Healthy sleep habits are essential for children with ASD and their caregivers to properly engage in their everyday lives. Occupational therapists are trained to evaluate clients in areas that contribute to sleep dysfunction and to focus on promoting optimal sleep performance. There is limited research on caregivers’ perceptions of their child’s sleep disturbances, these disturbances’ influence on occupational engagement, and whether occupational therapists have collaborated with caregivers of children with ASD to treat this area of occupation. Collecting data from caregivers by using a questionnaire can provide occupational therapy (OT) practitioners …

Measuring Mental Health Literacy: Adaptation And Validation Of The Portuguese Version Of The Mental Health Literacy Scale (Mhls), David Dias Neto, Ines Rocha, Maria João Figueiras, Ana Nunes Da Silva

All Works

Understanding mental health literacy is essential for promoting empowerment and proactivity in patients, reducing stigma, and increasing population awareness. The constitutive dimensions of mental health literacy are still being researched, and instruments’ research can shed light on the involved processes. The Mental Health Literacy Scale (MHLS) is a self-report measure of mental health literacy. This study aimed to adapt the MHLS to Portuguese and evaluate mental health literacy in a broad sample. A broad sample of 337 individuals participated in the adaptation. Besides filling out the MHLS, the participants were invited to fill out a general lifestyle measure. The global …

Early Assessment Of Lung Function In Coronavirus Patients Using Invariant Markers From Chest X-Rays Images, Mohamed Elsharkawy, Ahmed Sharafeldeen, Fatma Taher, Ahmed Shalaby, Ahmed Soliman, Ali Mahmoud, Mohammed Ghazal, Ashraf Khalil, Norah Saleh Alghamdi, Ahmed Abdel Khalek Abdel Razek, Eman Alnaghy, Moumen T. El-Melegy, Harpal Singh Sandhu, Guruprasad A. Giridharan, Ayman El-Baz

All Works

The primary goal of this manuscript is to develop a computer assisted diagnostic (CAD) system to assess pulmonary function and risk of mortality in patients with coronavirus disease 2019 (COVID-19). The CAD system processes chest X-ray data and provides accurate, objective imaging markers to assist in the determination of patients with a higher risk of death and thus are more likely to require mechanical ventilation and/or more intensive clinical care.To obtain an accurate stochastic model that has the ability to detect the severity of lung infection, we develop a second-order Markov-Gibbs random field (MGRF) invariant under rigid transformation (translation or …

An Occupation-Based Program To Promote Mental Health Of At-Risk Youth In An After-Care Setting, Alexa Smith

Student Capstone Papers

The disproportionate tendency for young adults from disadvantaged backgrounds to shift from schools to the juvenile justice system is referred to as the “school to prison pipeline”. Treating and preventing mental health difficulties is within the scope of occupational therapy, and while the school system assists in mental health treatment, there is a lack of mental health supporting services in after-care settings. The purpose of the program development project is to increase the supportive mental health services provided to at-risk youth in the after-care setting. The project ran mental health group sessions using Cole’s Seven Step Model with participant groups …