Medicine and Health Sciences Commons^™

A Hidden Crisis During Covid-19: How Have Intimate Partner Violence Screening Guidelines For Pregnant Patients Changed Since The Start Of The Global Covid-19 Pandemic?, Zayba Afshar

University Honors Theses

Introduction: Due to the risks of pregnancy outcomes in relation to IPV and the increased rates of IPV as a result of COVID-19 precautions, health care screening for IPV in the prenatal process is even more imperative for preventing negative healthcare outcomes for both the pregnant patient and children.

Background: Intimate partner violence (IPV) is a significant public health issue that puts both baby and pregnant patients at risk for severe negative healthcare outcomes. Healthcare screening is a tool to find a condition or to learn more about a patient before symptoms become severe.

Methods: Screening for …

A Screen For Sleep And Starvation Resistance Identifies A Wake-Promoting Role For The Auxiliary Channel Unc79, Kazuma Murakami, Justin Palermo, Bethany A. Stanhope, Allen G. Gibbs, Alex C. Keene

Life Sciences Faculty Research

The regulation of sleep and metabolism are highly interconnected, and dysregulation of sleep is linked to metabolic diseases that include obesity, diabetes, and heart disease. Furthermore, both acute and long-term changes in diet potently impact sleep duration and quality. To identify novel factors that modulate interactions between sleep and metabolic state, we performed a genetic screen for their roles in regulating sleep duration, starvation resistance, and starvation-dependent modulation of sleep. This screen identified a number of genes with potential roles in regulating sleep, metabolism, or both processes. One such gene encodes the auxiliary ion channel UNC79, which was implicated in …

Obstetric Emergencies, Frederick U Eruo

Conference Presentation Abstracts

No abstract provided.

Prenatal Diagnosis, Frederick U Eruo

Conference Presentation Abstracts

No abstract provided.

Update On The Role Of Allergy In Pediatric Functional Abdominal Pain Disorders: A Clinical Perspective., Craig A. Friesen, Jennifer Colombo, Jennifer Verrill Schurman

Manuscripts, Articles, Book Chapters and Other Papers

Both functional abdominal pain disorders (FAPDs) and food allergies are relatively common in children and adolescents, and most studies report an association between FAPDs and allergic conditions. FAPDs share pathophysiologic processes with allergies, including both immune and psychological processes interacting with the microbiome. No conclusive data are implicating IgE-mediated reactions to foods in FAPDs; however, there may be patients who have IgE reactions localized to the gastrointestinal mucosa without systemic symptoms that are not identified by common tests. In FAPDs, the data appears stronger for aeroallergens than for foods. It also remains possible that food antigens initiate an IgG reaction …

Coping With Medical School: An Interpretive Phenomenological Study, Sebastian C K Shaw, John L. Anderson

The Qualitative Report

Anecdotal evidence suggested that hopelessness and helplessness (HH) were often reported by undergraduate medical students. It is known that medical students are more susceptible to high levels of stress and depression than other student groups. There is currently concern about suicide rates in students and high drop-out rates in junior doctors. But what can be said of HH within this population? This study was aimed at eliciting medical students’ experiences of HH. An interpretive phenomenological approach was adopted. Participants were recruited from a single medical school. Loosely structured, audio-recorded interviews were carried out. Recordings were then transcribed verbatim, then underwent …

Correlations Between Cognitive Pause Patterns And Listener Perceptions Of Communicative Effectiveness And Likeability For People With Aphasia, Heidi Raylene Mcconaghie

Theses and Dissertations

A prevalent feature of typical spontaneous speech are speech pauses. Longer speech pauses, known as cognitive pauses, occur in typical speech and are indicative of higher-level cognitive processes. Atypical cognitive pauses, however, are prevalent in the speech of people with aphasia consequent to their communication disorder. Research has shown that these atypical pauses may contribute to negative listener perceptions. This study aimed to determine the influence of atypical speech pause on listener perceptions of communicative effectiveness and speaker likeability. Specifically, this study evaluated the relationship between listener ratings of communicative effectiveness and likeability and acoustic measures of between-utterance pause duration, …

The Influence Of Pause On Listeners' Perceptions In Speech Of People With Aphasia, Emily Wright

Theses and Dissertations

The purpose of this study was to examine how varying pause lengths in speech of people with aphasia (PWA) influences listeners' perceptions. The study specifically assesses listeners' perceptions of communicative effectiveness and speaker likability. Speech samples from six people with nonfluent or fluent aphasia were obtained from a previous study conducted by Harmon (2018). The speech samples were modified to create four sets of stimuli, including the original recordings, normalized within utterance pauses, normalized between utterance pauses, and normalized for both within and between utterance pauses. Forty listeners rated each of the speech samples based on the perceived communicative effectiveness …

Nlrp3 Inflammasome Is A Key Driver Of Obesity-Induced Atrial Arrhythmias, Larry Scott, Anke C Fender, Arnela Saljic, Luge Li, Xiaohui Chen, Xiaolei Wang, Dominik Linz, Jilu Lang, Mathias Hohl, Darragh Twomey, Thuy T Pham, Rodrigo Diaz-Lankenau, Mihail G Chelu, Markus Kamler, Mark L Entman, George E Taffet, Prashanthan Sanders, Dobromir Dobrev, Na Li

Faculty, Staff and Students Publications

AIMS: Obesity, an established risk factor of atrial fibrillation (AF), is frequently associated with enhanced inflammatory response. However, whether inflammatory signaling is causally linked to AF pathogenesis in obesity remains elusive. We recently demonstrated that the constitutive activation of the 'NACHT, LRR, and PYD Domains-containing Protein 3' (NLRP3) inflammasome promotes AF susceptibility. In this study, we hypothesized that the NLRP3 inflammasome is a key driver of obesity-induced AF.

METHODS AND RESULTS: Western blotting was performed to determine the level of NLRP3 inflammasome activation in atrial tissues of obese patients, sheep, and diet-induced obese (DIO) mice. The increased body weight in …

Plotting The Literature On Precautionary Measures Of Covid-19: A Scientometric Analysis Of Web Of Science, Muhammad Shoaib, Nusrat Ali, Abeel Naseer

Library Philosophy and Practice (e-journal)

This study attempted to evaluate the scholarly publications on COVID-19, social distance, physical distance, social isolation, and self-isolation employing the scientometric analysis technique from 2020 to 2021. The main purpose was to consolidate the published scholarship on the COVID-19 in the Web of Science indexed documents. A total of 635 publications were found. The results indicated that social distance and COVID-19 was the top topic along with the article as a type of document, and the majority were published in the English language in 2021. The name of Gimenez-Llort L was at top of the list of authors, along with …

Covid-19 And Delayed Cerebral Ischemia—More In Common Than First Meets The Eye, Pervinder Bhogal, Levansri Makalanda, Ameer E. Hassan, Dave Fiorella, Tommy Andersson, Muhammad Ahmad, Hansjörg Bäzner, Ounali Jaffer, Hans Henkes

School of Medicine Publications

Since the arrival of the global COVID-19 pandemic scientists around the world have been working to understand the pathological mechanisms resulting from infection. There has gradually been an understanding that COVID-19 triggers a widespread endotheliopathy and that this can result in a widespread thrombosis and in particular a microthrombosis. The mechanisms involved in the microthrombosis are not confined to infection and there is evidence that patients with aneurysmal sub-arachnoid haemorrhage (SAH) also suffer from an endotheliopathy and microthrombosis. In this article we attempt to shed light on similarities in the underlying processes involved in both diseases and suggest potential treatment …

Outpatient Anticoagulation Management, Anne Du Breuil, Md

Department of Family & Community Medicine Presentations and Grand Rounds

Objectives

• Warfarin Management
• Anticoagulation Module in Epic
• Brief summary of Direct Oral Anticoagulants (DOACs)
• Brief Perioperative Anticoagulation Tips

Apigenin Ameliorates Hepatic Lipid Accumulation By Activating The Autophagy-Mitochondria Pathway, Man Chen Hsu, Bei Chia Guo, Po-An Hu, Chia Hui Chen, Tzong-Shyuan Lee

Journal of Food and Drug Analysis

Apigenin, a flavonoid isolated from plants, provides protection against non-alcoholic fatty liver disease. However, the mechanism by which apigenin decreases lipid accumulation in the liver is unclear. In this study, we investigated the molecular mechanism underlying the beneficial effect of apigenin on the hepatic deregulation of lipid metabolism. Oleic acid (OA)-induced lipid accumulation in human hepatoma cells (Huh7 cells) was used as an in vitro model. Western blot analysis was used for evaluating protein expression. Oil red O staining, Nile red staining, and conventional assay kits were used to assess the level of lipids. Immunocytochemistry was performed to observe mitochondrial …

Life Skill Development And Its Impact On Perceived Stress, Employment And Education Pursuits: A Study Of Young Adults With A History Of Homelessness And Trauma, Josephine Beker, Tina M. Deangelis

Student Journal of Occupational Therapy

An occupational therapy educational training group for young adults in permanent supported housing was developed, implemented and evaluated with pre-post outcome measures including Goal Attainment Scaling (GAS) and the Perceived Stress Scale-10 (PSS-10). The study explored stress levels and employment-related goals of individuals who have aged out of the foster care system and may also have had a history of chronic homelessness and trauma. Results demonstrated a trend towards significance in perceived stress 9Z=1.689, p=0.91) with 7 of 8 participants surpassing the expected outcome according to GAS. Limitations included a small convenience sample (n=8), inconsistent attendance and use of self-report …

Optimization Of Training Tools For Sambo Wrestlers At The Stage Of Sport Improvement, Shukurjon Shukhrat Ugli Gaziev

Eurasian Journal of Sport Science

Purpose: The purpose of our research is to increase the level of pre-competitive readiness of highly qualified sambo wrestlers at the stage of sports improvement .

Methods: The study uses methods of analysis of scientific and methodological literature, questionnaires; pedagogical observations; medical and biological research methods; control tests on a five-stage program for increasing general and special physical fitness; pedagogical experiment; mathematical and statistical analysis of the data obtained.

Results: The Dynamic of the number of turns in a series of fights in the experimental group at the beginning of the study also had a tendency to a sharp decrease …

Covid-19 Newsletter (Vol. 76), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

2021 June 15 - Medical Student Education Committee Annual Meeting Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

2021 June 15 - Medical Student Education Committee Retreat Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

2021-06-15_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

Hr Wellness Programs At Ohiohealth Wellness Department, Yuanze Ma

Masters Theses/Capstone Projects

Goals of this project include learning and practicing related clinical skills, develop work based thinking method, gain clinical knowledge of workplace wellness programs, and expanding knowledge on program’s implementation and improvement, analyze existing programs and challenge me with innovation, learning how wellness program practice during a special environment (epidemic), learning and gain leadership skill through the process, expending vision and formulating future career plans.

There were positive and negative outcomes of this experience. I have learned the wellness program implementation and helped with several programs design and operations. I have gained leadership skills from involving in meeting discussions. I have …

2021-06-15_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-526911--,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The information below represents COVID-19 data reported directly to MDHHS by licensed and operating Skilled Nursing, Home for the Aged and Adult Foster Care facilities (licensed to serve 13 or more individuals) in Michigan from January 1, 2020. All long-term care facilities additionally have an obligation to report COVID-positive residents and/or staff …

Comparing Household And Individual Measures Of Access Through A Food Environment Lens: What Household Food Opportunities Are Missed When Measuring Access To Food Retail At The Individual Level?, Lindsey G. Smith, Michael J. Widener, Bochu Liu, Steven Farber, Leia M. Minaker, Zachary Patterson, Kristian Larsen, Jason Gilliland

Geography & Environment Publications

Geographers and public health researchers have long been interested in social, spatial, and economic factors that drive access and exposure to food retail. A growing body of evidence draws on mobility data to capture locations accessed by individuals beyond the home address. Given that food-related activities are shared by household members and often gendered, taking an individual-level approach might limit researchers’ ability to accurately describe access to food retail. Using data that includes Global Positioning System trajectories of forty-six adults from twenty-one households in Toronto, this study compares access to food retailers at the individual and household levels and evaluates …

Rna-Seq Reveals Changes In Human Placental Metabolism, Transport And Endocrinology Across The First-Second Trimester Transition., Malwina Prater, Russell S Hamilton, Hong Wa Yung, Andrew M Sharkey, Paul Robson, N Erlyani Abd Hamid, Eric Jauniaux, D Stephen Charnock-Jones, Graham J Burton, Tereza Cindrova-Davies

Faculty Research 2021

The human placenta is exposed to major environmental changes towards the end of the first trimester associated with full onset of the maternal arterial placental circulation. Changes include a switch from histotrophic to hemotrophic nutrition, and a threefold rise in the intraplacental oxygen concentration. We evaluated their impact on trophoblast development and function using RNA-sequencing (RNA-Seq) and DNA-methylation analyses performed on the same chorionic villous samples at 7-8 (n=8) and 13-14 (n=6) weeks of gestation. Reads were adjusted for fetal sex. Most DEGs were associated with protein processing in the endoplasmic reticulum (ER), hormone secretion, transport, extracellular matrix, vasculogenesis, and …

2021-06-15_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2021-06-15_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Monday - Saturday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …

Covid-19 Multi-Targeted Drug Repurposing Using Few-Shot Learning, Yang Liu, You Wu, Xiaoke Shen, Lei Xie

Publications and Research

The life-threatening disease COVID-19 has inspired significant efforts to discover novel therapeutic agents through repurposing of existing drugs. Although multi-targeted (polypharmacological) therapies are recognized as the most efficient approach to system diseases such as COVID-19, computational multi-targeted compound screening has been limited by the scarcity of high-quality experimental data and difficulties in extracting information from molecules. This study introduces MolGNN , a new deep learning model for molecular property prediction. MolGNN applies a graph neural network to computational learning of chemical molecule embedding. Comparing to state-of-the-art approaches heavily relying on labeled experimental data, our method achieves equivalent or superior prediction …

Microglial Implications In Sars-Cov-2 Infection And Covid-19: Lessons From Viral Rna Neurotropism And Possible Relevance To Parkinson's Disease, Ifeoluwa O. Awogbindin, Benneth Ben-Azu, Babatunde A. Olusola, Elizabeth T. Akinluyi, Philip A. Adeniyi, T. Di Paolo, Marie-Eve Tremblay

Faculty Publications

Since December 2019, humankind has been experiencing a ravaging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak, the second coronavirus pandemic in a decade after the Middle East respiratory syndrome coronavirus (MERS-CoV) disease in 2012. Infection with SARS-CoV-2 results in Coronavirus disease 2019 (COVID-19), which is responsible for over 3.1 million deaths worldwide. With the emergence of a second and a third wave of infection across the globe, and the rising record of multiple reinfections and relapses, SARS-CoV-2 infection shows no sign of abating. In addition, it is now evident that SARS-CoV-2 infection presents with neurological symptoms that include early …

The Discrepancy Between Admission And Discharge Diagnoses: Underlying Factors And Potential Clinical Outcomes In A Low Socioeconomic Country, Samar Fatima, Sara Shamim, Amna Subhan Butt, Safia Awan, Simra Riffat, Muhammed Tariq

Section of Internal Medicine

Objective: The discrepancy between admission and discharge diagnosis can lead to possible adverse patient outcomes. There are gaps in integrated studies, and less is understood about its characteristics and effects. Therefore, this study was conducted to determine the frequency, characteristics, and outcomes of diagnostic discrepancies at admission and discharge.
Design and data sources: This retrospective study reviewed the admitting and discharge diagnoses of adult patients admitted at Aga Khan University Hospital (AKUH), Internal Medicine Department between October 2018 and February 2019. The frequency and outcomes of discrepancies in patient diagnoses were noted among Emergency Department (ED) physician versus admitting physician, …

Pregnant Women With Substance Use Disorders Deserve Plans Of Safe Care, Alexandra E. Punch, Monika Taylor

Population Health Research Brief Series

Substance use among women who are pregnant is a growing U.S public health issue. Approximately 340,000 infants are affected by prenatal exposure to illicit drugs annually, leading to an increase in Neonatal Abstinence Syndrome (NAS), and Child Protective Services involvement. This issue brief describes the current state of prenatal substance use and provides guidance on the use of federally mandated Plans of Safe Care to help mothers prepare for the arrival of their baby while navigating their substance use disorder.

Differential Effect Of Proinflammatory Cytokines On Corneal And Conjunctival Epithelial Cell Mucins And Glycocalyx, Kiumars Shamloo, Priya Mistry, Ashley Barbarino, Christopher Ross, Vishal Jhanji

Pharmacy Faculty Articles and Research

Purpose: Ocular surface mucins and glycocalyx are critical for providing ocular hydration as well lubrication and repelling pathogens or allergens. Elevated levels of tear proinflammatory cytokines in dry eye may have detrimental effect on mucins and glycocalyx. The present study tested the effect of proinflammatory cytokines IL-6, TNF-α, and IFN-γ on membrane-tethered mucins expression, glycocalyx, and viability of ocular surface epithelial cells.

Methods: Stratified cultures of human corneal and conjunctival epithelial cells were exposed to different concentrations of IL-6, TNF-α, and IFN-γ for 24 hours. The mucins gene and protein expressions were quantified by real-time polymerase chain reaction …