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Articles 7411 - 7440 of 21408
Full-Text Articles in Medicine and Health Sciences
Analysis And Modeling Of Strategic Interactions In Health Systems To Improve Patient Care Access, Jorge A. Acuña Melo
Analysis And Modeling Of Strategic Interactions In Health Systems To Improve Patient Care Access, Jorge A. Acuña Melo
USF Tampa Graduate Theses and Dissertations
Affordable health care access that provides well-coordinated and high-quality services on time is a goal that governments and health organizations strive for. Regrettably, most countries deal with access problems that affect the population's health, such as long waiting lists for specialized medical services, overcrowding of emergency departments, and high health prices. In the present doctoral dissertation, I model and analyze the strategic interactions that inhabit the health system machinery to uncover possible structural problems that led to the aforementioned issues. The study involves operation research, data science, and game theory techniques to address the health care access predicament.
Each research …
The Utility Of Continuous Passive Motion After Anterior Cruciate Ligament Reconstruction: A Systematic Review Of Comparative Studies, Taylor D'Amore, Somnath Rao, John Corvi, Robert Jack Ii, Fotios Tjoumakaris, Michael G. Ciccotti, Kevin Freedman
The Utility Of Continuous Passive Motion After Anterior Cruciate Ligament Reconstruction: A Systematic Review Of Comparative Studies, Taylor D'Amore, Somnath Rao, John Corvi, Robert Jack Ii, Fotios Tjoumakaris, Michael G. Ciccotti, Kevin Freedman
Department of Orthopaedic Surgery Faculty Papers
Background: The application of continuous passive motion (CPM) after anterior cruciate ligament reconstruction (ACLR) was popularized in the 1990s, but advancements in the understanding of ACLR rehabilitation have made the application of CPM controversial. Many sports medicine fellowship–trained surgeons report using CPM machines postoperatively. Purpose: To determine the efficacy of CPM use for recovery after ACLR with respect to knee range of motion (ROM), knee swelling, postoperative pain, and postoperative complications. Study Design: Systematic review; Level of evidence, 3. Methods: The PubMed (MEDLINE), EMBASE, Cochrane, Cumulative Index of Nursing, and Allied Health Literature databases were searched from inception to January …
Gunshot Wounds To The Foot And Ankle: Review Of Cases From A Level-1 Trauma Center, Allicia O. Imada, Jory Wasserburger, Aamir N. Ahmad, Katherine Gavin
Gunshot Wounds To The Foot And Ankle: Review Of Cases From A Level-1 Trauma Center, Allicia O. Imada, Jory Wasserburger, Aamir N. Ahmad, Katherine Gavin
Western Journal of Orthopaedics
Background: Gunshot injuries frequently involve the foot and ankle. The standard of care for treatment of gunshot injuries to the foot and ankle is not clear. To better understand these injuries, we completed a retrospective review of foot and ankle gunshot injuries at a level-1 trauma center seen as orthopaedic consults over a 2-year period. Methods: Orthopaedic consults for foot and ankle gunshot injuries from June 1st, 2018, through May 31st, 2020, were reviewed. Patient characteristics, zone of injury, mechanism of injury, associated injuries, treatment, follow-up, and outcomes were recorded. Results: Forty-eight foot and ankle gunshot injuries were identified, encompassing …
Distal Radial Shaft Malunion And Distal Radioulnar Joint Instability 8 Years After Postoperative Plate Failure: A Case Report, Allicia O. Imada, Casey D. Mcdonald, Deana Mercer
Distal Radial Shaft Malunion And Distal Radioulnar Joint Instability 8 Years After Postoperative Plate Failure: A Case Report, Allicia O. Imada, Casey D. Mcdonald, Deana Mercer
Western Journal of Orthopaedics
Radius shaft fractures often require operative treatment after skeletal maturity to restore functional range of motion. If the radial bow is not anatomically restored, pain and instability can occur from bony impingement and disruption of the distal radioulnar joint (DRUJ). We describe a 25-year-old woman with a radius shaft malunion and DRUJ instability. Eight years prior, at the age of 17, she underwent open reduction and internal fixation for a radial shaft fracture with subsequent reinjury at 10 weeks postoperatively. The reinjury was treated nonoperatively, and the patient went on to have painful range of motion and DRUJ instability. Radiographs …
Bisphosphonate Associated Atypical Femur Fracture And Contralateral Impending Atypical Femur Fracture In A Pediatric Patient With Osteogenesis Imperfecta: A Case Report, Benjamin Albertson, Taylor Polander, Selina Silva
Bisphosphonate Associated Atypical Femur Fracture And Contralateral Impending Atypical Femur Fracture In A Pediatric Patient With Osteogenesis Imperfecta: A Case Report, Benjamin Albertson, Taylor Polander, Selina Silva
Western Journal of Orthopaedics
Atypical femur fractures are rare, low-energy fractures that involve a specific constellation of radiographic findings. These fractures have been well described in adult osteoporotic patients on long-term bisphosphonates; however, little to no literature exists on atypical femur fractures in pediatric patients on long-term bisphosphonates. The use of bisphosphonates as treatment of osteogenesis imperfecta is common to reduce fracture rate and improve bone mineral density. We describe a 15-year-old adolescent boy with type I osteogenesis imperfecta on long-term bisphosphonate therapy. He presented with an atypical right femur fracture and an impending left femur fracture. To the authors’ knowledge, these findings represent …
New Diagnosis Of X-Linked Agammaglobulinemia Presenting As Multi-Focal Acute Pseudomonal Osteomyelitis And Septic Arthritis In A 16-Month Old Boy: A Case Report, Walter Dehority
Western Journal of Orthopaedics
A previously healthy 16-month-old boy presented with 5 days of fever, a limp favoring his right side, and swelling and erythema of the dorsal left foot and left great toe. Contrasted magnetic resonance imaging revealed septic arthritis of the left knee, the interphalangeal joint of the left great toe, and the left subtalar and ankle joints. He had osteomyelitis of the left talus and intraosseous abscess formation in the left calcaneus. Cultures of the blood, left knee synovial fluid, and abscess fluid all showed growth of Pseudomonas aeruginosa. He was subsequently diagnosed with X-linked agammaglobulinemia with a novel mutation in …
Reconstruction Of A Chronic Quadriceps Tendon Rupture After Multiple Failed Repair Attempts: Technique And Case Report, Lauren Edge, Elizabeth Mcleod, Om Pathak, Justin Bartley
Reconstruction Of A Chronic Quadriceps Tendon Rupture After Multiple Failed Repair Attempts: Technique And Case Report, Lauren Edge, Elizabeth Mcleod, Om Pathak, Justin Bartley
Western Journal of Orthopaedics
Rupture of the quadriceps tendon is a relatively uncommon injury that requires prompt surgical intervention to restore the function of the extension apparatus of the knee. Early, definitive surgical intervention generally produces excellent results. In the case of delayed surgery or re-rupture, the tendon is often retracted and scarred, thus complicating subsequent repairs and resulting in poor outcomes. We describe a middle-aged man who presented 4 years after his initial quadriceps rupture, following two repair attempts that failed. Upon presentation, he was unable to perform any active extension at the knee, and he ambulated with the use of a hinged …
Bilateral Peroneal Tendon Subluxation Associated With Complex Hindfoot Fractures: A Case Report, Benjamin C. Howse, Benjamin D. Packard, Rick J. Gehlert
Bilateral Peroneal Tendon Subluxation Associated With Complex Hindfoot Fractures: A Case Report, Benjamin C. Howse, Benjamin D. Packard, Rick J. Gehlert
Western Journal of Orthopaedics
A 41-year-old man presented to the emergency department after crashing his dirt bike and sustaining bilateral subtalar fracture dislocations. The left talus underwent open reduction internal fixation. At his first postoperative visit, the patient was found to have bilateral peroneal tendon subluxation (PTS). This case report discusses the cause of PTS and the challenges associated with accurate identification and diagnosis of this injury. We review the diagnostic and therapeutic challenges associated with injury, the negative impact on clinical outcomes, and the association between PTS and hindfoot trauma.
The Experiences Of Women As Latinx Osteopathic Medical Students, Dana L. Weiss
The Experiences Of Women As Latinx Osteopathic Medical Students, Dana L. Weiss
Theses and Dissertations
In existing literature, researchers have predominantly examined issues related to minoritized groups by juxtaposing differences and outcomes among groups without attention to the diversity of experiences, challenges and strengths. This has had a limiting focus on the experiences specific to women as Latinx medical students, and has created a gap which restricts knowledge about experiences of perceived support and barriers within osteopathic medical school. This research provided an opportunity to think more deeply and critically about the experiences for women as Latinx osteopathic medical students. The data collected in this qualitative phenomenological study was gathered from participants as they narrated …
Comparing Plastic Surgery And Otolaryngology Surgical Outcomes And Cartilage Graft Preferences In Pediatric Rhinoplasty: A Retrospective Cohort Study Analyzing 1839 Patients., Andres F. Doval, Ariel Ourian, Kieran S. Boochoon, Vishwanath Chegireddy, Michael Lypka, Anthony Echo
Comparing Plastic Surgery And Otolaryngology Surgical Outcomes And Cartilage Graft Preferences In Pediatric Rhinoplasty: A Retrospective Cohort Study Analyzing 1839 Patients., Andres F. Doval, Ariel Ourian, Kieran S. Boochoon, Vishwanath Chegireddy, Michael Lypka, Anthony Echo
Manuscripts, Articles, Book Chapters and Other Papers
Rhinoplasty in children has raised concerns about its safety in the pediatric population. There is scarcity of evidence describing outcomes and surgical techniques performed in pediatric rhinoplasty. We analyzed post-operative complications and cartilage preferences between plastic surgeons and otolaryngologists.Data was collected through the Pediatric National Surgical Improvement Program from 2012 to 2017. Current Procedure Terminology codes were used for data extraction. Patients were grouped according to type of rhinoplasty procedures (primary, secondary, and cleft rhinoplasty). A comparison between plastic surgeons and otolaryngologists was made in each group in terms of postoperative complications. Additionally, a sub-group analysis based on cartilage graft …
Front Matter, Unm Department Of Orthopaedic Surgery
Front Matter, Unm Department Of Orthopaedic Surgery
Western Journal of Orthopaedics
No abstract provided.
Alumni Map 2021, Unm Department Of Orthopaedic Surgery
Alumni Map 2021, Unm Department Of Orthopaedic Surgery
Western Journal of Orthopaedics
No abstract provided.
Considerations In Surgical Timing For Femoral Shaft Fractures, Trevor Crean, William Curtis, Thomas A. Decoster
Considerations In Surgical Timing For Femoral Shaft Fractures, Trevor Crean, William Curtis, Thomas A. Decoster
Western Journal of Orthopaedics
Femoral shaft fractures are a common orthopaedic injury. They are generally treated with intramedullary nailing. The optimal timing of operative treatment is variable and debated. Relatively simple femoral shaft fractures can be successfully treated in less than 24 hours in most health care systems. Femoral shaft fractures can be more complicated owing to various factors, such as multiple traumatic injuries, associated conditions, etc. These more complicated femoral shaft fractures benefit from stabilization within the first 6 hours to minimize complications. Stabilization of the long bones helps achieve an upright chest position and improves pulmonary, circulatory, and musculoskeletal function. Some patients …
Seven Deadly Sins Of Volar Distal Radius Fracture Fixation, Allicia O. Imada, Jorge Orbay, Deana Mercer
Seven Deadly Sins Of Volar Distal Radius Fracture Fixation, Allicia O. Imada, Jorge Orbay, Deana Mercer
Western Journal of Orthopaedics
Distal radius fractures are common injuries, accounting for 17.0% of all emergency department visits. Operative treatment is an option when indicated. Volar plating has become the most frequently used mode of fixation. Although fixed angle volar locking plates allow for reliable and stable fixation, complications have been reported. Complications include flexor and extensor tendon rupture, intra-articular screw penetration, malreduction, loss of reduction, carpal tunnel syndrome, implant failure, and complex regional pain syndrome. We propose seven principles to avoid these preventable outcomes and tips to succeed.
A Systematic Review To Examine Functional Recovery After Total Knee Arthroplasty And Successful Physical Therapy Protocols, Dominique M. Patterson, Colin F.K. Hansen, Yuri Yoshida
A Systematic Review To Examine Functional Recovery After Total Knee Arthroplasty And Successful Physical Therapy Protocols, Dominique M. Patterson, Colin F.K. Hansen, Yuri Yoshida
Western Journal of Orthopaedics
Background: Total knee arthroplasty (TKA) continues to be the most common elective procedure performed every year, with the goal to reduce pain and improve return to functional activities. Recent studies have investigated new surgical techniques and therapeutic interventions to determine which protocols result in reduced pain and accelerate return to function. Methods: We systematically reviewed 131 out of 301 studies between 1996 and 2019 to assess trends in patient functional performance and perceptive functional recovery after TKA from preoperative up to 2 years postoperative. We evaluated functional outcome measures recommended by the Osteoarthritis Research Society International. Results that considerably deviated …
Effect Of Patient-Surgeon Orientation On Plunge Depth During Plate Fixation Of Clavicle Fractures, Aaron Mullane, Layla A. Haidar, Adam Kozemchak, Colton Wayne
Effect Of Patient-Surgeon Orientation On Plunge Depth During Plate Fixation Of Clavicle Fractures, Aaron Mullane, Layla A. Haidar, Adam Kozemchak, Colton Wayne
Western Journal of Orthopaedics
Background: Operative management of clavicle fractures indicated for open reduction internal fixation poses significant risk to critical anatomic structures. The associated risks to the underlying neurovascular structures during clavicle fixation as a result of plunge depth for patients in the supine position in comparison to patients in the beach-chair position is currently unknown. The purpose of this study was to compare plunge depth measurements between the supine and beach-chair positions during plate fixation of clavicle fractures. Methods: The participant population at this single institution was comprised of residents, fellows, and fellowship-trained, attending orthopaedic surgeons. The participants drilled three bicortical holes …
A Novel Method In The Classification Of Proximal Fifth Metatarsal Fractures, Kathryn Yeager, Benjamin Packard, Richard A. Miller, Shravin Sridhar
A Novel Method In The Classification Of Proximal Fifth Metatarsal Fractures, Kathryn Yeager, Benjamin Packard, Richard A. Miller, Shravin Sridhar
Western Journal of Orthopaedics
Background: Proximal fifth metatarsal fractures are common. The authors previously performed a study examining the inter- and intraobserver reliability of the Lawrence and Botte Classification, which showed poor interobserver reliability of 16.67%. A novel approach was proposed for the classification of fifth metatarsal fractures using a mortise ankle radiographic view. Methods: The observers from the authors’ prior study reviewed non-weight bearing mortise views of 20 patients with isolated fifth metatarsal base fractures. These radiographs were identified from the 60 radiographs from the authors’ prior study. Five physicians evaluated the radiographs and classified the fractures as type 1, 2, or 3. …
Early Open Reduction And Internal Fixation Of Acute Low-Energy Tibial Plateau Fractures Does Not Increase The Rate Of Perioperative Complications, Jorge D. Guerra, Madison Craft, Diana P. Guerra, Ahmed M. Thabet
Early Open Reduction And Internal Fixation Of Acute Low-Energy Tibial Plateau Fractures Does Not Increase The Rate Of Perioperative Complications, Jorge D. Guerra, Madison Craft, Diana P. Guerra, Ahmed M. Thabet
Western Journal of Orthopaedics
Introduction: The treatment algorithm for tibial plateau fractures continues to evolve as surgeon experience increases. Initial surgical procedures have been fine-tuned over time. Methods: This is a retrospective chart review of 132 patients with low-energy tibial plateau fractures (Schatzker I–IV) treated at a level-1 academic trauma center between January 2008 and February 2018. This study analyzes patient outcomes managed with primary operative intervention within 48 hours of admission. The average age was 45 years (range, 19 to 84 years). There were 92 men and 40 women. Statistical analysis focused on comparisons between historical complication rates and the findings of this …
Risk Factors For The Development Of A Symptomatic Contralateral Discoid Lateral Meniscus, Jason Nielson, Sean Davis, Aaron Gray, Brock Wentz
Risk Factors For The Development Of A Symptomatic Contralateral Discoid Lateral Meniscus, Jason Nielson, Sean Davis, Aaron Gray, Brock Wentz
Western Journal of Orthopaedics
Background: Discoid menisci (DM) are oval or disc shaped menisci, differing from the normal crescent shaped meniscus. This difference in shape may be one factor as to why DM are more prone to injury when compared to normal menisci. The purpose of this study was to evaluate potential risk factors that may lead to the development of symptoms, requiring arthroscopic saucerization in adolescents with a history of symptomatic DM in the contralateral extremity. Methods: We retrospectively reviewed 126 patients with an arthroscopic diagnosis of DM to evaluate for the presence of a symptomatic contralateral DM variant. Mildly symptomatic DM status …
Hamstring Strength Recovery In Relation To Landing Patterns Following Anterior Cruciate Ligament Reconstruction: A Case Comparison Report, Kelsey A. Edwards, Rebecca A. Dutton, Yuri Yoshida, Dustin L. Richter
Hamstring Strength Recovery In Relation To Landing Patterns Following Anterior Cruciate Ligament Reconstruction: A Case Comparison Report, Kelsey A. Edwards, Rebecca A. Dutton, Yuri Yoshida, Dustin L. Richter
Western Journal of Orthopaedics
Introduction: Deficits in quadriceps strength following anterior cruciate ligament reconstruction (ACLR) are common and can be associated with biomechanical asymmetries during landing tasks. The relationship between quadriceps strength and knee function during ACLR recovery is well established. However, less is known regarding the role of hamstring strength in functional recovery after ACLR. We examined movement patterns during a drop-landing task in three patients following ACLR with different levels of quadriceps and hamstring strength. Methods: Three participants were assessed for quadriceps and hamstrings strength, functional performance, and lower-extremity biomechanics captured by a 3D motion analysis 6 months after ACLR. Results: Participant …
A Novel High Tibial Biplanar Osteotomy Technique For Simultaneous Coronal And Sagittal Correction: A Case Example, Ryan C. Price, Kathryn C. Helmig, Dustin L. Richter, Robert C. Schenck Jr
A Novel High Tibial Biplanar Osteotomy Technique For Simultaneous Coronal And Sagittal Correction: A Case Example, Ryan C. Price, Kathryn C. Helmig, Dustin L. Richter, Robert C. Schenck Jr
Western Journal of Orthopaedics
Medial opening wedge high tibial osteotomy (HTO) can provide symptom relief, improved ligamentous stability, and lower failure rates in patients with symptomatic medial knee osteoarthritis, ligament instability, and varus alignment after ligament reconstruction. It has been reported that correcting coronal plane abnormalities with a medial opening wedge HTO has resulted in altered posterior tibial slope angle (PTSA). We describe a 38-year-old woman with a history of severe polytrauma who presented with an anterior cruciate ligament tear in the setting of increased PTSA and a posterolateral corner injury with varus deformity of the knee. A medial biplanar HTO was performed using …
Cartilage Restoration Of The Patella Using Prochondrix® Osteochondral Allograft: A Case Report, Evan D. Boyd, Michael S. Barnum, James R. Slauterbeck
Cartilage Restoration Of The Patella Using Prochondrix® Osteochondral Allograft: A Case Report, Evan D. Boyd, Michael S. Barnum, James R. Slauterbeck
Western Journal of Orthopaedics
Articular cartilage injuries are challenging to treat because of the limited healing potential of articular cartilage. Various cartilage restoration procedures have been developed to restore the protective role of articular cartilage and to delay or prevent additional damage to the articular surface. ProChondrix® Cartilage Restoration Matrix is a cryopreserved hyaline cartilage allograft with viable chondrocytes and growth factors necessary to promote its incorporation and viability. We describe a 19-year-old man with a well-contained, full-thickness cartilage defect on his patella. He subsequently underwent cartilage restoration with a ProChondrix® osteochondral allograft. At 1-year postoperatively, the patient had both clinical and radiographic evidence …
Orthopaedic Residency And The Covid Kid, Finley Kemp, Deana Mercer
Orthopaedic Residency And The Covid Kid, Finley Kemp, Deana Mercer
Western Journal of Orthopaedics
N/A
Excessive Tibial Overgrowth Associated Ankle Valgus Deformity After Pediatric Open Mid-Shaft Tibial Fracture: A Case Report, Ahmed M. Thabet, Rami Khalifa, Rasheed Alnajjar, Amr Abdelgawad
Excessive Tibial Overgrowth Associated Ankle Valgus Deformity After Pediatric Open Mid-Shaft Tibial Fracture: A Case Report, Ahmed M. Thabet, Rami Khalifa, Rasheed Alnajjar, Amr Abdelgawad
Western Journal of Orthopaedics
Tibial overgrowth after pediatric tibial fractures has been reported in the literature. Multiple factors can affect the amount of overgrowth, including age and gender of patients, type of fracture (open vs closed), degree of communion, reduction techniques, and fixation method. We describe a 10-year-old boy with a 2-cm overgrowth after sustaining an isolated open tibia fracture with an intact fibula, which is more than what has been previously described in the literature for tibia fractures. This overgrowth was associated with asymmetrical growth of the distal tibial physis, asymmetrical growth between tibia and fibula, and ankle valgus deformity.
The University Of New Mexico Orthopaedics Research Journal 2021, Unm Department Of Orthopaedic Surgery
The University Of New Mexico Orthopaedics Research Journal 2021, Unm Department Of Orthopaedic Surgery
Western Journal of Orthopaedics
No abstract provided.
The Evaluation Of Medical Student International Mission Trips: A Rapid Review, Andrew Kamel
The Evaluation Of Medical Student International Mission Trips: A Rapid Review, Andrew Kamel
Master of Public Health Capstone Presentations
Previous reviews of the literature on medical mission trips have noted that there is a dearth of rigorous data collection and evaluation of the efficacy of medical missions to low- and middle-income countries (LMICs). Medical students are increasingly participating in these trips as global health curriculums become more popular and prevalent, and the literature about these international experiences has not been well-described. This rapid review aims to characterize the evaluation of medical mission trips for medical students to LMICs. This article is a rapid review of the literature using PRIMSA guidelines to search PubMed for studies about the evaluation of …
Prevalence Of Pressure Ulcers In Long-Term Care Facilities: A Focus On Older Adults, Joseph M. Callaghan, Iii
Prevalence Of Pressure Ulcers In Long-Term Care Facilities: A Focus On Older Adults, Joseph M. Callaghan, Iii
Master of Public Health Capstone Presentations
Pressure Ulcers (PUs) are wounds resulting from skin breakdown. They are common among those who have mobility limitations, and older adults, particularly those residing in nursing homes (NHs) and long-term care facilities (LTCFs). PUs cost U.S. and international healthcare systems millions of dollars per year. For all of these reasons, PUs represent a continuing public health threat.
Our review provides an update on the prevalence of PUs in LTCFs and NHs, especially regarding older adults. We used a single-reviewer, modified PRISMA-P process to conduct a rapid review of the literature. Relevant search terminology were input into PubMed and Scopus® …
Circumcision As An Intervening Strategy Against Hiv Acquisition In The Male Genital Tract, Adhikarimayum Lakhikumar Sharma, Joseph Hokello, Mudit Tyagi
Circumcision As An Intervening Strategy Against Hiv Acquisition In The Male Genital Tract, Adhikarimayum Lakhikumar Sharma, Joseph Hokello, Mudit Tyagi
Center for Translational Medicine Faculty Papers
Unsafe sex with HIV-infected individuals remains a major route for HIV transmission, and protective strategies, such as the distribution of free condoms and pre-or post-prophylaxis medication, have failed to control the spread of HIV, particularly in resource-limited settings and high HIV prevalence areas. An additional key strategy for HIV prevention is voluntary male circumcision (MC). International health organizations (e.g., the World Health Organization, UNAIDS) have recommended this strategy on a larger scale, however, there is a general lack of public understanding about how MC effectively protects against HIV infection. This review aims to discuss the acquisition of HIV through the …
The Effect Of Ametropia On Glaucomatous Visual Field Loss., Eun Young Choi, Raymond C.S. Wong, Thuzar Thein, Louis R. Pasquale, Lucy Q. Shen, Mengyu Wang, Dian Li, Qingying Jin, Hui Wang, Neda Baniasadi, Michael V. Boland, Siamak Yousefi, Sarah R. Wellik, Carlos G. De Moraes, Jonathan S. Myers, Peter J. Bex, Tobias Elze
The Effect Of Ametropia On Glaucomatous Visual Field Loss., Eun Young Choi, Raymond C.S. Wong, Thuzar Thein, Louis R. Pasquale, Lucy Q. Shen, Mengyu Wang, Dian Li, Qingying Jin, Hui Wang, Neda Baniasadi, Michael V. Boland, Siamak Yousefi, Sarah R. Wellik, Carlos G. De Moraes, Jonathan S. Myers, Peter J. Bex, Tobias Elze
Wills Eye Hospital Papers
Myopia has been discussed as a risk factor for glaucoma. In this study, we characterized the relationship between ametropia and patterns of visual field (VF) loss in glaucoma. Reliable automated VFs (SITA Standard 24-2) of 120,019 eyes from 70,495 patients were selected from five academic institutions. The pattern deviation (PD) at each VF location was modeled by linear regression with ametropia (defined as spherical equivalent (SE) starting from extreme high myopia), mean deviation (MD), and their interaction (SE × MD) as regressors. Myopia was associated with decreased PD at the paracentral and temporal VF locations, whereas hyperopia was associated with …
Upregulation Of Endogenous Trail-Elicited Apoptosis Is Essential For Metformin-Mediated Antitumor Activity Against Tnbc And Nsclc, Shuang Liu, Erik V. Polsdofer, Lukun Zhou, Sanbao Ruan, Hui Lyu, Defu Hou, Hao Liu, Ann D. Thor, Zhimin He, Bolin Liu
Upregulation Of Endogenous Trail-Elicited Apoptosis Is Essential For Metformin-Mediated Antitumor Activity Against Tnbc And Nsclc, Shuang Liu, Erik V. Polsdofer, Lukun Zhou, Sanbao Ruan, Hui Lyu, Defu Hou, Hao Liu, Ann D. Thor, Zhimin He, Bolin Liu
School of Medicine Faculty Publications
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) shows promising antitumor activity in preclinical studies. However, the efficacy of recombinant TRAIL in clinical trials is compromised by its short serum half-life and low in vivo stability. Induction of endogenous TRAIL may overcome the limitations and become a new strategy for cancer treatment. Here, we discovered that metformin increased TRAIL expression and induced apoptosis in triple-negative breast cancer (TNBC) and non-small cell lung cancer (NSCLC) cells. Metformin did not alter the expression of TRAIL receptors (TRAIL-R1/DR4 and TRAIL-R2/DR5). Metformin-upregulated TRAIL was secreted into conditioned medium (CM) and found to be functional, since the …