Medicine and Health Sciences Commons^™

Combatting Depression In Young Adult Transgender Individuals, Joshua Chronis, Anna Kang, Tzu Ning Liu, Serena Simpson, Stephen Venable, Benjamin Wright, Aditi Kappagantu

Patient Education Projects

No abstract provided.

Creating A Community-Oriented Ckd Grocery Guide To Improve Patient Outcomes, Caroline Grubbs, Cullen Hudson, Cynthia Matos Molina, Bobak Ossareh, Narmeen Rehman, Kalemelekot Taye, Rujuta Patil

Patient Education Projects

No abstract provided.

Use Of Interactive Learning To Increase Activity In Children, Husain Al-Saffar, Kriti Babu, Kelsey Gockman, John Kulka, Lauren Wylie, Kassandra Solsrud

Patient Education Projects

No abstract provided.

A Broken Heart - A Short Poem About Cardiovascular Disease Awareness, Aman-Vir Mandair, Rebecca Schultz, Jacob Slominski, Christofer Smith, Nicole Xu, Mathew Kunz

Patient Education Projects

No abstract provided.

How Exercise Can Decrease Symptoms Of Depression In Elementary School Children, Nathan Alessio-Bilowus, Aliaa Bahzad, Shivansh Desai, Iyanna Peppers, Zoha Qureshi, Shivang Shah, Michael Franklin

Patient Education Projects

No abstract provided.

Coping Mechanism For Anxiety And Depression – An Informational Pamphlet, David Bai, Lewis Graham, Sarah Henry, Megan Nicholson, Bianca Parker, Phyo Win, Kyle Garcia

Patient Education Projects

No abstract provided.

Quality-Adjusted Time Without Symptoms Of Disease Or Toxicity (Q-Twist) Analysis Of Cpx-351 Versus 7 + 3 In Older Adults With Newly Diagnosed High-Risk/Secondary Aml, Jorge E Cortes, Tara L Lin, Geoffrey L Uy, Robert J Ryan, Stefan Faderl, Jeffrey E Lancet

2020-Current year OA Pubs

BACKGROUND: CPX-351 (United States: Vyxeos

METHODS: Patients were randomized 1:1 between December 20, 2012 and November 11, 2014 to receive induction with CPX-351 or 7 + 3. Survival time for each patient was partitioned into 3 health states: TOX (time with any grade 3 or 4 toxicity or prior to remission), TWiST (time in remission without relapse or grade 3 or 4 toxicity), and REL (time after relapse). Within each treatment arm, Q-TWiST was calculated by adding the mean time spent in each health state weighted by its respective quality-of-life, represented by health utility. The relative Q-TWiST gain, calculated as …

Coding And Noncoding Variants In Ebf3 Are Involved In Hadds And Simplex Autism, Evin M Padhi, Jeffrey K Ng, Elvisa Mehinovic, Tychele N Turner, Et Al.

2020-Current year OA Pubs

BACKGROUND: Previous research in autism and other neurodevelopmental disorders (NDDs) has indicated an important contribution of protein-coding (coding) de novo variants (DNVs) within specific genes. The role of de novo noncoding variation has been observable as a general increase in genetic burden but has yet to be resolved to individual functional elements. In this study, we assessed whole-genome sequencing data in 2671 families with autism (discovery cohort of 516 families, replication cohort of 2155 families). We focused on DNVs in enhancers with characterized in vivo activity in the brain and identified an excess of DNVs in an enhancer named hs737. …

Review Of Sexual Health Issues Linked With Cardiovascular Disease And Type 2 Diabetes Mellitus In Aboriginal And Torres Strait Islander Males, Veronica Collins, Tamara J. Swann, Jane Burns, Tim Moss, Mick Adams

Australian Indigenous HealthBulletin

There are well established links between male sexual health conditions and chronic disease, particularly cardiovascular disease (CVD) and type 2 diabetes (T2DM). Erectile dysfunction (ED) and low testosterone are two sexual health conditions that are relatively common among the wider male population. However, there is a lack of data specifically about these sexual problems among Aboriginal and Torres Strait Islander males.

One of the most important findings of research regarding the links between sexual health and chronic disease is that ED can be a risk marker for future CVD or undiagnosed T2DM. Understanding these links can lead to more holistic …

Modeling Of Island Block Scatter For Intensity Modulated Bolus Electron Conformal Therapy, Joseph G. Scotto

LSU Master's Theses

Purpose: Bolus electron conformal therapy (BECT) benefits treatment of the post-mastectomy chest wall, head and neck, paraspinal muscles, and extremities. Patient dose heterogeneities caused by bolus can be reduced through intensity modulation (IM) across the incident electron beam. This requires passive radiotherapy intensity modulation for electrons (PRIME) devices, which utilize tungsten pins (island blocks) imbedded in machinable foam. IM-BECT treatment planning requires accurate dose calculation using the pencil beam redefinition dose algorithm (PBRA). Currently, the PBRA models island blocks as perfect collimators. This work explores models to account for electrons scattering into and out of the sides of island blocks. …

A Cross-Sectional Survey Of Online Health Information Seeking Behavior Pattern Of Undergraduate Students In A Nigerian Private University, Oluwaseun Eniola Adegbilero-Iwari, Tunrayo Oluwadare, Idowu Adegbilero-Iwari

Library Philosophy and Practice (e-journal)

Given the wide-ranging influence of the internet on people in this digital age and the extensive reliance of young people on internet-enabled mobile devices, our study aimed to assess the pattern of online health information seeking behavior among undergraduate students in a Nigerian private university. Employing the cross-sectional survey design and purposive sampling technique, three hundred and four (304) undergraduates took part in the study. A semi-structured questionnaire was used to collect information on the socio-demographic characteristics, participant’s use of the internet, online health information seeking behaviour and use of online health information. The results showed that the mean age …

Effects Of Cod Liver Oil On Brain Antioxidant Level And Neuronal Count In Wistar Rat Model Of Comorbid Depression, Dimple Shet

Faculty work

No abstract provided.

Ada News - 07/12/2021, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Supporting Students After A Concussion: School Administrators’ Perspectives, Tricia M. Kasamatsu, Tamara C. Valovich Mcleod, Johna K. Register, Cailee E. Welch Bacon

Perspectives In Learning

Students with a concussion may experience challenges when returning to school and completing schoolwork. Therefore, students may require temporary academic support throughout the recovery process. The purpose of this study was to examine school administrators’ perceptions of the return to school process and provision of academic adjustments (AA) after concussion. Online surveys were analyzed using a series of descriptive, chi-square, and Mann Whitney tests. School administrators strongly agreed a concussion can affect school performance and were supportive of providing AA for symptomatic students. More school administrators with access to an athletic trainer and who completed concussion training had an established …

Fos Rescues Neuronal Differentiation Of Sox2-Deleted Neural Stem Cells By Genome-Wide Regulation Of Common Sox2 And Ap1(Fos-Jun) Target Genes., Miriam Pagin, Mattias Pernebrink, Mattia Pitasi, Federica Malighetti, Chew Yee Ngan, Sergio Ottolenghi, Giulio Pavesi, Claudio Cantù, Silvia K Nicolis

Faculty Research 2021

The transcription factor SOX2 is important for brain development and for neural stem cells (NSC) maintenance. Sox2-deleted (Sox2-del) NSC from neonatal mouse brain are lost after few passages in culture. Two highly expressed genes, Fos and Socs3, are strongly downregulated in Sox2-del NSC; we previously showed that Fos or Socs3 overexpression by lentiviral transduction fully rescues NSC's long-term maintenance in culture. Sox2-del NSC are severely defective in neuronal production when induced to differentiate. NSC rescued by Sox2 reintroduction correctly differentiate into neurons. Similarly, Fos transduction rescues normal or even increased numbers of immature neurons expressing beta-tubulinIII, but not …

Profiling Variable-Number Tandem Repeat Variation Across Populations Using Repeat-Pangenome Graphs., Tsung-Yu Lu, Human Genome Structural Variation Consortium, Mark J P Chaisson, Charles Lee, Qihui Zhu

Faculty Research 2021

Variable number tandem repeats (VNTRs) are composed of consecutive repetitive DNA with hypervariable repeat count and composition. They include protein coding sequences and associations with clinical disorders. It has been difficult to incorporate VNTR analysis in disease studies that use short-read sequencing because the traditional approach of mapping to the human reference is less effective for repetitive and divergent sequences. In this work, we solve VNTR mapping for short reads with a repeat-pangenome graph (RPGG), a data structure that encodes both the population diversity and repeat structure of VNTR loci from multiple haplotype-resolved assemblies. We develop software to build a …

Utilizing Image And Caption Information For Biomedical Document Classification., Pengyuan Li, Xiangying Jiang, Gongbo Zhang, Juan Trelles Trabucco, Daniela Raciti, Cynthia Smith, Martin Ringwald, G Elisabeta Marai, Cecilia Arighi, Hagit Shatkay

Faculty Research 2021

MOTIVATION: Biomedical research findings are typically disseminated through publications. To simplify access to domain-specific knowledge while supporting the research community, several biomedical databases devote significant effort to manual curation of the literature-a labor intensive process. The first step toward biocuration requires identifying articles relevant to the specific area on which the database focuses. Thus, automatically identifying publications relevant to a specific topic within a large volume of publications is an important task toward expediting the biocuration process and, in turn, biomedical research. Current methods focus on textual contents, typically extracted from the title-and-abstract. Notably, images and captions are often used …

Baricitinib In The Treatment Of A Critical Patient With Covid-19 Pneumonia: A Case Report, Nishant Patel, Dylan Goldsmith, Forest W. Arnold

The University of Louisville Journal of Respiratory Infections

A 72-year-old male presented to the emergency department with a chief complaint of diarrhea after having tested positive for COVID-19 two days prior. He initially had minimal respiratory complaints, but was eventually transferred to the intensive care unit for acute hypoxic respiratory failure. In addition to dexamethasone, remdesivir, and antibiotics, the patient was treated with baricitinib, a Janus kinase inhibitor that was recently granted emergency use authorization by the Food and Drug Administration for treatment of hospitalized patients with COVID-19. He had an extensive and complicated hospital course and had to be placed on mechanical ventilation, ultimately undergoing tracheostomy. After …

Effectiveness Of Peer Counseling And Membership In Breastfeeding Support Groups In Promoting Optimal Breastfeeding Behaviors In The Philippines, Ofelia P. Saniel, Veincent Christian F. Pepito, Arianna Maever L. Amit

Ateneo School of Medicine and Public Health Publications

Background

The prevalence of early initiation of breastfeeding and exclusive breastfeeding (EBF) at 6 months remain low in the Philippines. To help meet the 90% early initiation of breastfeeding target and to improve infant and young child feeding practices in the Philippines, the Millennium Development Goals - Fund 2030 Joint Programme (JP) on Ensuring Food Security and Nutrition for Children 0–24 months old was implemented. We aimed to determine the effectiveness of visits by peer counselors during pregnancy and after delivery, and membership in breastfeeding support groups in promoting these optimal breastfeeding practices.

Methods

We used data from the Endline …

The Relationship Between Emotion Regulation And Substance Use Treatment Attrition, Melanie Ruth Roys

LSU Doctoral Dissertations

Severe substance use disorders are characterized by chronic cycles of relapse; however, individuals who complete substance use treatment are less likely to experience relapse. Research has focused on trying to identify factors that predict treatment dropout to help improve treatment outcomes. Most of this research has focused on examining demographic and patient-specific factors, with little success in reliably predicting treatment attrition. There has been less focus on investigating transdiagnostic factors that span across discrete psychological diagnoses and demographics. The present study sought to determine if self-report and behavioral measures related to emotion regulation predicted inpatient substance use treatment dropout above …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Georgia Southern, Abraham Baldwin Agricultural College’s new agreement fast-tracks degrees for students in public health programs, bolsters state health care workforce

Effectiveness Of A Multidisciplinary Chronic Pain Management Program In A Local Pain Center, Charlotte L. Barker, Danielle A. Sultan, Woon Yuen Koh, Stephen Z. Hull, Ling Cao

Osteopathic Medicine Student Publications

Objectives: There has been increased recognition of multidisciplinary approach for managing chronic pain. There is a high incidence of co-morbid depression and anxiety as well as functional disability impacting activities of daily living with chronic pain diagnoses. In the current study, we assessed the effectiveness of an affordable Living Life Well Pain Rehabilitation Program (LLWPRP), developed in a local outpatient chronic pain clinic. Methods: Retrospective data analysis using data collected from May 2012 - May 2015 with total of 86 patients was performed. The LLWPRP is a 12-week program with biweekly meetings. It involves a combination of education about pain, …

Epilepsy In Older People In Sub-Saharan Africa: A Systematic Review, Martha Sajatovic

Faculty Scholarship

Background: Over one-fourth of new onset epilepsy occurs after age 60. However, the burden of epilepsy and other seizure disorders among this special population in Africa is largely unknown, despite a growingnumber of elderly persons on the continent. This study aimed to assess the prevalence and risk factors for epilepsy among persons aged 60 years or older in Africa. Methods: We conducted a systematic review by searching MEDLINE (via) and EMBASE databases from inception to 30th October 2020. Primary researches reporting prevalence or incidence of seizures or epilepsy in older persons (≥60 years) were included. Review articles were excluded. Results: …

A Comparison Of Shear Bond Strength Of Brackets Bonded To Zirconia, Hannah Knott, Xiaoming Xu, Edwin Kee, Qingzhao Yu, Paul Armbruster, Richard Ballard

School of Dentistry Faculty Publications

Purpose: The objective of this study was to compare the shear bond strength (SBS) of ceramic orthodontic brackets bonded to highly translucent zirconia surfaces following the use of two different primers. Materials and methods: Three types of highly translucent zirconia crowns, Cercon xt ML, e.max ZirCAD, and STML-ML Katana Zirconia, were milled, sandblasted, and primed using two zirconia primers, Monobond Etch and Prime and Z-Prime Plus. A ceramic bracket (Radiance) was bonded onto the facial surface of each crown. Shear bond strength was evaluated using a universal testing machine. Results: There was no significant overall difference across the six experimental …

Ocular Safety Of Repeated Intravitreal Injections Of Carboplatin And Digoxin: A Preclinical Study On The Healthy Rabbits., Alireza Khodabande, Fariba Ghassemi, Fahimeh Asadi Amoli, Hamid Riazi-Esfahani, Raziyeh Mahmoudzadeh, Mohammad Mehrpour, Niloufar Valipour

Wills Eye Hospital Papers

To evaluate the ocular safety of intravitreal carboplatin and digoxin injections as a new intravitreal chemotherapy option for retinoblastoma tumor vitreous seeds. Eighteen rabbits were divided randomly into three groups to receive intravitreal injection of Digoxin (6 rabbits), Carboplatin (7 rabbits), or Saline (5 rabbits). In every group, one eye randomly treated with 10 µg Digoxin in 0.1 cc or 1 µg Carboplatin or Saline, and the contralateral eye was considered as the control. All groups underwent three consecutive injections of the drugs with 1-week intervals. Baseline electroretinography (ERG) was recorded from both eyes of all the animals prior to …

Stress And Molecular Drivers For Cancer Progression: A Longstanding Hypothesis, Justin Wendel, A. Verma, Vijian Dhevan, Subhash C. Chauhan, Manish Tripathi

School of Medicine Publications

Stress management is becoming very important part of cancer patient care. Chronic stressors lead to boost tumorigenesis and promote cancer development, recurrence, and drug resistant leading to poor health outcomes. The Hypothalamic-Pituitary-Adrenal (HPA) axis, which is activated by stress, also regulates Hypothalamic-Pituitary-Thyroid (HPT) axis. Stress related changes in immune function and inflammatory response also leads to reduced immune surveillance resulting in tumorigenesis. This article explores the hormonal axis impacted by stress and how chronic stress can lead to poor outcome of a cancer patient.

Later Sleep Timing Predicts Accelerated Summer Weight Gain Among Elementary School Children: A Prospective Observational Study, Jennette P Moreno, Javad Razjouyan, Houston Lester, Hafza Dadabhoy, Mona Amirmazaheri, Layton Reesor-Oyer, Teresia M O'Connor, Daphne C Hernandez, Bijan Najafi, Candice A Alfano, Stephanie J Crowley, Debbe Thompson, Tom Baranowski

Children’s Nutrition Research Center Staff Publications

Objectives and background: Social demands of the school-year and summer environment may affect children's sleep patterns and circadian rhythms during these periods. The current study examined differences in children's sleep and circadian-related behaviors during the school-year and summer and explored the association between sleep and circadian parameters and change in body mass index (BMI) during these time periods.

Methods: This was a prospective observational study with 119 children ages 5 to 8 years with three sequential BMI assessments: early school-year (fall), late school-year (spring), and beginning of the following school-year in Houston, Texas, USA. Sleep midpoint, sleep duration, variability of …

In-Vitro And In-Silico Investigations Of Alternative Surgical Techniques For Single Ventricular Disease, Arka Das

Doctoral Dissertations and Master's Theses

Single ventricle (SV) anomalies account for one-fourth of all cases of congenital Heart disease. The conventional second and third stage i.e. Comprehensive stage II and Fontan procedure of the existing three-staged surgical approach serving as a palliative treatment for this anomaly, entails multiple complications and achieves a survival rate of 50%. Hence, to reduce the morbidity and mortality rate associated with the second and third stages of the existing palliative procedure, the novel alternative techniques called “Hybrid Comprehensive Stage II” (HCSII), and a “Self-powered Fontan circulation” have been proposed. The goal of this research is to conduct in-vitro investigations to …

Data From Emergency Medicine Palliative Care Access (Empalla): A Randomized Controlled Trial Comparing The Effectiveness Of Specialty Outpatient Versus Telephonic Palliative Care Of Older Adults With Advanced Illness Presenting To The Emergency Department., Abigail M. Schmucker, Mara Flannery, Jeanne Cho, Keith S. Goldfeld, Corita Grudzen, Empalla Investigators

Student Papers, Posters & Projects

BACKGROUND: The Emergency Medicine Palliative Care Access (EMPallA) trial is a large, multicenter, parallel, two-arm randomized controlled trial in emergency department (ED) patients comparing two models of palliative care: nurse-led telephonic case management and specialty, outpatient palliative care. This report aims to: 1) report baseline demographic and quality of life (QOL) data for the EMPallA cohort, 2) identify the association between illness type and baseline QOL while controlling for other factors, and 3) explore baseline relationships between illness type, symptom burden, and loneliness.

METHODS: Patients aged 50+ years with advanced cancer (metastatic solid tumor) or end-stage organ failure (New York …

Risdiplam For The Use Of Spinal Muscular Atrophy, Juyeon Kakazu, Nakoma L. Walker, Katherine C. Babin, Katherine A. Trettin, Christopher Lee, Patricia B. Sutker, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Spinal muscular atrophy (SMA) is one of the leading causes of death in infants related to the degeneration of neurons. Currently, there are no curative treatment options for SMA, and many options available may not be feasible. This review presents the background, clinical studies, and indications for the use of Risdiplam in treating SMA. SMA causes a decrease in the production of survival motor neuron proteins (SMN) and current treatments target to increase the expression of SMN. Risdiplam is the first and only oral medication to be approved to treat SMA. As an SMN2 splicing modifier, it has provided stronger …