Medicine and Health Sciences Commons^™

Clinical Executive Healthcare Leadership At Ohiohealth, Ladan Barnes

Masters Theses/Capstone Projects

OhioHealth’s Riverside Methodist Hospital with the site supervisor, Chief of Medical Affairs, Dr. Thomas Harmon.

The residency focused on executive health care leadership and the principles, skillsets, and experiences needed to perform the duties of the Vice President of Medical Affairs and Chief of Medical Affairs positions.

The residency provided opportunities to work on projects regarding goal deployment for Women’s Health Services.

Throughout the experience safety, and quality were guiding pinnacles OhioHealth values to excel in all areas in the clinical enterprise.

The residency allowed for in-depth evaluation of healthcare executive leadership with a large focus on clinical health executive …

Serum Renin And Major Adverse Kidney Events In Critically Ill Patients: A Multicenter Prospective Study, Alexander H. Flannery, Victor M. Ortiz-Soriano, Xilong Li, Fabiola G. Gianella, Robert D. Toto, Orson W. Moe, Prasad Devarajan, Stuart L. Goldstein, Javier A. Neyra

Pharmacy Practice and Science Faculty Publications

BACKGROUND: Preliminary studies have suggested that the renin-angiotensin system is activated in critical illness and associated with mortality and kidney outcomes. We sought to assess in a larger, multicenter study the relationship between serum renin and Major Adverse Kidney Events (MAKE) in intensive care unit (ICU) patients.

METHODS: Prospective, multicenter study at two institutions of patients with and without acute kidney injury (AKI). Blood samples were collected for renin measurement a median of 2 days into the index ICU admission and 5-7 days later. The primary outcome was MAKE at hospital discharge, a composite of mortality, kidney replacement therapy, or …

Comparative Analysis Of Longevity And Stress Resiliency Benefits Of Supplementation With High-Antioxidative Capacity Juices In Organisms That Are Representative Of Humans, Meghan Long

Honors Scholar Theses

Neurodegenerative disease presents itself in a complex array of illnesses that is increasingly affecting the geriatric population. There has not been research on a common cause since there are a culmination of reasons that are probable ranging from genetic to environmental factors. Antioxidants have been known to prevent and protect against the damage that is otherwise caused by reactive oxygen species (ROS). Thus, high-capacity antioxidant juices supplemented into the diet of animal models such as Caenorhabditis elegans, Drosophila melanogaster, rats, and humans will allow for the study of the possible benefits.

Although a conclusion and common causation on the usage …

Malnutrition And Liver Disease In A Developing Country, Asra Tus Saleha Siddiqui, Om Parkash, Syeda Amrah Hashmi

Section of Gastroenterology

Malnutrition is a highly prevalent and under recognized condition in developing countries of South Asia. The presence of malnutrition causes a severe impact on patients with liver cirrhosis. The etiology of cirrhosis differs in the South Asian region compared to the West, with hepatitis B and C still being the leading causes and the prevalence of nonalcoholic fatty liver disease increasing over time. Comorbid malnutrition worsens outcomes for cirrhosis patients. Urgent attention to address malnutrition is needed to improve patient outcomes. The etiology and pathophysiology of malnutrition in liver diseases is multifactorial, as reduction in liver function affects both macronutrients …

Psychological Problems Among Patients With Chronic Medical Disorders During The Covid-19 Pandemic, Ali Akbar Asadi-Pooya, Seyed Ali Nabavizadeh, Saeid Sadeghian, Mina Shahisavandi, Zohreh Barzegar, Abdullah Nezafat, Nahid Ashjazadeh, Hamed Bazrafshan Drissi, Ali Sahraian

Department of Neurology Faculty Papers

The aim of the current study was to investigate the rates of stress, anxiety, and depression among people in south Iran (a group from the general population without a history of any chronic medical problems, and cohorts of patients were recruited from epilepsy, diabetes, and cardiac disease clinics). We surveyed a sample of people during September 2020: a group of the general population without a history of any chronic medical problems, people with epilepsy, people with diabetes mellitus (DM), and people with cardiac problems. The survey included four general questions and two COVID-19 specific questions [contracting COVID-19, relatives with COVID-19]. …

The “East Side” Of Las Vegas: A Latinx Historical Framework, Nathalie Martinez

Spectra Undergraduate Research Journal

Spanish heritage speakers in the United States are a reflection of everchanging linguistic and sociolinguistic pressures that result in myriad varieties across generations. This paper provides a preliminary historical framework to fill this gap of linguistic knowledge in the Spanish-speaking community of Las Vegas, Nevada. The goals were two-fold: (1) highlight the largest Spanish-speaking communities in Las Vegas and (2) explore the significance of the East Side in the history of the Latinx population of Las Vegas. Through the analysis of oral histories and historical works, the investigation highlights the Mexican, Salvadoran, and Cuban populations of Las Vegas and their …

Qualitative Review Of Educational Interventions For Improving Physical Activity Behaviors In Older Asian Americans In The United States, Raisa Kabir, Manoj Sharma, Sayeda Tazim Zaidi, Chia-Liang Dai

Spectra Undergraduate Research Journal

Physical activity (PA) provides numerous health benefits and minimizes chronic diseases and mental health issues, especially in older adults. The national survey data indicated that only 27.3% to 44.3% of older adults meet the recommended PA guidelines of 150 to 300 minutes/ week. There is limited data on PA behavior among older Asian American (AA) adults as very few to no local/national surveys have targeted these marginalized subgroups. This comprehensive review aims to identify existing PA intervention strategies and to update current knowledge on the effectiveness of these interventions to improve PA behavior among aging AA in the US. The …

The Future Of The Live Entertainment Tax In Southern Nevada, Katie M. Gilbertson

Spectra Undergraduate Research Journal

The Live Entertainment Tax (LET) in Nevada generated nearly one billion dollars during the 2019-2020 fiscal year. LET revenue all goes to the State General Fund, even though 97 percent of LET revenue is generated in Clark County. Nevada is experiencing an economic crisis, particularly in the tourism industry. Solutions from various fields suggest the best way to boost the local economy is to reinvest revenue in its original county. One policy solution Nevada policymakers should consider is to carve out a percentage of revenue generated by the LET to return directly back to Clark County to revitalize tourism.

Diabetes Mellitus Affects Working Memory, Dylone C. Braganza, Emmanuel Flores, Lauren A. Crew, Ryan A. Wirt, Andrew A. Ortiz, Adam M. Mcneela, Jefferson W. Kinney, James M. Hyman

Spectra Undergraduate Research Journal

Alzheimer’s disease (AD) degrades the brain’s ability to remember, think, and carry out tasks. The exact cause is not known, but several risk factors have been identified, including diabetes mellitus (DM). DM causes elevated blood sugar levels due to reduced insulin production in the pancreas. The linkage between elevated glucose levels and the behavioral impairments are not fully understood, which was the focus of this study. Rats were trained to alternate directions in a maze to receive a reward on consecutive trials. After training, five rats were injected with streptozotocin (STZ), which induces hyperglycemia by injuring pancreatic beta cells. Three …

A Timeline Of Discovery And Current Research On Primary Open-Angle Glaucoma And Emergence Of Potentially Permanent Treatment Solutions, Yonosuke Dejesus, Guadalupe Moreno Ceballos

Spectra Undergraduate Research Journal

This research examines the timeline of the discovery and research of Primary Open-Angle Glaucoma (POAG). By reviewing the literature on genetic and molecular mechanisms, we aim to emphasize a long-term treatment solution (iSTENT) to mitigate intraocular pressure (IOP) related to POAG etiology and disease progression. POAG is a multifactorial, autosomal dominant, adult-onset eye disease wherein the optic nerve cells become damaged due to a buildup of excess aqueous humor, resulting in increased IOP. Consequently, POAG leads to progressive loss of peripheral vision and is the leading cause of blindness in the US. Due to the multifactorial nature of glaucoma’s inheritance …

Racial Profiling: Understanding The Practice Of Stop-And-Frisk In New York City, Lisa Ly

Spectra Undergraduate Research Journal

Racial profiling has become a prominent issue in modern policing today. Instead of being based on individual suspicion, racial profiling embodies a belief that people of color are continuously singled out by the police for scrutiny and harassment. Policies and procedures make the Black community vulnerable to police discrimination and racial profiling. Floyd et al. v. City of New York et al. (2013) declared that the New York Police Department’s (NYPD) practice of stop-and-frisk was racially profiling Black civilians. This study sought (1) to determine if the NYPD post-Floyd is still engaging in racial profiling towards Black civilians; and (2) …

2021-08-13_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated three times a week on Mondays, Wednesdays, and Fridays.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, …

Coronavirus Update 8-13-21, The Coronavirus Planning Team

University Briefings & Virtual Events

We continue to prepare for your arrival with great excitement for the year ahead. Today is the deadline for uploading proof of your first vaccine (or single vaccine if you received Johnson & Johnson) or your request for a medical or religious exemption.

2021-08-13_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted three times a week on Mondays, Wednesdays and Fridays.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time …

Behavioral Health At Nationwide Nationwide Children's Hospital Practicum Experience, Muna Sharif

Masters Theses/Capstone Projects

The mission of this practicum experience is to provide the highest quality of care to all children and their families regardless of their ability to pay.

From this experience I was able to develop a comprehensive understanding of the Behavioral Health programs and services at Nationwide Children's Hospital. Additionally, I facilitated the Eating Disorder Intake Process Team Discussion. I attended daily huddles and engaged in discussion while learning from professional leaders. This also included regularly being hands-on in activities and attending all meetings, providing feedback, and debriefing with the site-supervisor.

What Are The Most Effective Risk Factor Management Strategies For The Prevention And Control Of Hypertension?, Sherlyne Barasa

Theses and Graduate Projects

Hypertension (HTN) affects millions of people globally. With the rising burden of HTN in primary care and its associated morbidity and mortality, it is necessary to explore effective risk factor management to control and prevent it in people most at risk. This research addressed both modifiable risk factors such as obesity, smoking, alcohol, and diet as well as non- modifiable risk factors such as age, race/ethnicity, and family history. The aim of this paper was to examine the most effective risk factor management strategies to control and prevent hypertension. The studies reviewed indicate that there are various risk factor management …

Occupational Factors And Risk For Preterm Birth, Kelsey Forbes

Theses and Graduate Projects

Introduction: Preterm birth (PTB) is a leading contributor to infant death globally and in the United States. The biological mechanisms and etiologies for PTB are not well understood making prevention challenging. The correlation between increased number of women in the workforce and increased incidence of PTB in the U.S. inspired a thorough review of occupational risk factors that may contribute to shortened gestational length.

Background: The studies reviewed assessed the following occupational factors and their association with PTB: physical job demands, exposure to whole-body vibration and noise, shift work, long working hours, and psychosocial job strain.

Methods: A systematic search …

Neuronal Nsun2 Deficiency Produces Trna Epitranscriptomic Alterations And Proteomic Shifts Impacting Synaptic Signaling And Behavior., J Blaze, A Navickas, H L Phillips, S Heissel, A Plaza-Jennings, S Miglani, H Asgharian, M Foo, C D Katanski, C P Watkins, Z T Pennington, B Javidfar, S Espeso-Gil, B Rostandy, H Alwaseem, C G Hahn, H Molina, D J Cai, T Pan, W D Yao, H Goodarzi, F Haghighi, S Akbarian

Department of Neuroscience Faculty Papers

Epitranscriptomic mechanisms linking tRNA function and the brain proteome to cognition and complex behaviors are not well described. Here, we report bi-directional changes in depression-related behaviors after genetic disruption of neuronal tRNA cytosine methylation, including conditional ablation and transgene-derived overexpression of Nsun2 in the mouse prefrontal cortex (PFC). Neuronal Nsun2-deficiency was associated with a decrease in tRNA m⁵C levels, resulting in deficits in expression of 70% of tRNA^Gly isodecoders. Altogether, 1488/5820 proteins changed upon neuronal Nsun2-deficiency, in conjunction with glycine codon-specific defects in translational efficiencies. Loss of Gly-rich proteins critical for glutamatergic neurotransmission was associated with impaired …

2021-08-13_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2021-08-13_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Structural And Inhibitory Studies Of Enzymes Essential For Cell Wall And Ergothioniene Biosynthesis In Mycobacterium Tuberculosis, Thanuja D. Sudasinghe

Theses & Dissertations

Tuberculosis (TB) is one of the world’s oldest contagious diseases caused by Mycobacterium tuberculosis (M. tb). With the emergence and spread of drug-resistant M. tb strains, there is an urgent need to discover novel drugs and drug targets specifically against drug-resistant strains and dormant bacteria. This dissertation focuses on M. tbenzymes essential for the M. tb cell wall and ergothioneine biosynthesis. The M. tb cell wall acts as a protective barrier due to the presence of unique lipids and mycolic acids. Among these lipids, trehalose-dimycolate and mycolylarabinogalactan play a major role in constructing and maintaining the outer …

Health Service Utilization And Expenditure In Cardio-Metabolic Conditions In The United States Adults, Kavita Mosalpuria

Theses & Dissertations

Metabolic syndrome is multicomponent risk factor for cardiovascular diseases (CVD) and type 2 diabetes that reflects the clustering of at least 3 cardiometabolic risk factors, among hypertension, impaired glucose regulations, hypercholesterolemia, and obesity. CVD are the leading cause of death in the U.S. CVD occur at earlier age and is a major cause of death and disability among people with diabetes. As compared to Japan, 13.3% to 44% of the excess CVD mortality in the U.S. can be explained by the metabolic syndrome. The prevalence of metabolic syndrome was 34.3% in 2007 to 2014 and it increases with age. Metabolic …

Synthesis Of Nanofibers For The Development Of Artificial Tactile Sensor, Pertab Rai

International Programs

Tactile sensation in human skin is performed by specialized cells called mechanoreceptors. Factors such as surgical procedures, skin burns, injury, and nerve damage may lead to impaired sensation. For these reasons, various methods and approaches are developed to revive tactile sensation. In this poster, a step-by-step procedure to synthesize nanofibers for the development of artificial tactile sensor is presented.

Increasing Supervised Births For Women In Papua New Guinea Through The Baby Bundle Initiative, Simeon Adiunegiya

International Programs

Papua New Guinea’s high maternal death rate is closely related to high rate of unsupervised village deliveries, and is of grave public health concern. But to turn this around, women must be encourage to come to a health facility to deliver their babies. The baby bundle initiative is making significant progress in increasing supervised births for women in PNG’s Milne Bay Province.

Patient Experience As A Metric For Performance In Outpatient Bone Marrow Transplant Patient Populations, Olivia S. Marlinski

Master's Projects and Capstones

Problem: Patient satisfaction and perception of care provided have been linked to the overall quality of healthcare delivery. The Acute Infection Management clinical support department lacks a standardized method to collect information from patients regarding their satisfaction with care provided therefore impeding the units’ ability to capture performance results related to satisfaction, and improve care delivery processes accordingly.

Context: The Acute Infection Management unit is an outpatient clinical support department located within a large university-affiliated hospital that has been recently designated as the unit to operate the facility’s new outpatient bone marrow transplant program.

Intervention: The proposed project seeks to …

Metabolic Outcomes Of Anaplerotic Dodecanedioic Acid Supplementation In Very Long Chain Acyl-Coa Dehydrogenase (Vlcad) Deficient Fibroblasts, Igor Radzikh, Erica Fatica, Jillian Kodger, Rohan Shah, Ryan Pearce, Yana Sandlers

Chemistry Faculty Publications

Very long-chain acyl-CoA dehydrogenase deficiency (VLCADD, OMIM 609575) is associated with energy deficiency and mitochondrial dysfunction and may lead to rhabdomyolysis and cardiomyopathy. Under physiological conditions, there is a fine balance between the utilization of different carbon nutrients to maintain the Krebs cycle. The maintenance of steady pools of Krebs cycle intermediates is critical for mitochondrial energy homeostasis especially in high-energy demanding organs such as muscle and heart. Even-chain dicarboxylic acids are established as alternative energy carbon sources that replenish the Krebs cycle by bypassing a defective β-oxidation pathway. Despite this, even-chain dicarboxylic acids are eliminated in the urine of …

Proof Of Concept: The Use Of Renal Biomarkers In Critically Ill Pediatric Patients For Therapeutic Drug Monitoring, Christopher Lee Shaffer

Theses & Dissertations

Acute kidney injury (AKI) is a serious and common complication in critically ill pediatric patients. The incidence of pediatric AKI continues to increase, especially in patients who undergo surgical correction of congenital heart defects. Serum creatinine and urine output are the most commonly used tools to assess renal function, with international guidelines standardizing AKI-definitions based upon these parameters. However, changes in serum creatinine can occur 24 hours or later after a renal insult event, delaying the diagnosis and potential interventions to reverse injury. It is critical to identify endogenous renal biomarkers within the pediatric population that are both timely and …

Use Of Telehealth In Home-Based End-Of-Life Care For Children In Rural Regions, Meaghann S. Weaver

Theses & Dissertations

A national shortage in pediatric-trained providers results in certain geographies, primarily rural, where children with special needs are not able to access home-based care at their end-of-life. Advances in technology have made the use of telemedicine a potential modality for palliative care subspecialty clinicians to provide clinical care and support for adult-trained hospice teams. This dissertation utilizes four approaches to consider telehealth as an unexplored opportunity in care delivery: (1) a systematic review of telehealth measures and instruments to select the Technology Acceptance Model as a validated metric of telehealth acceptance uniquely now applied to pediatric care; (b) a pilot …

The Effect Of Simvastatin On Periodontonal Inflammation In Periodontal Maintenance Patients, Devin L. Christiansen

Theses & Dissertations

The purpose of this analysis of inflammation markers from a double blinded, randomized, controlled clinical trial was to determine if local application of simvastatin, combined with minimally invasive papilla reflection/root preparation (PR/RP) is effective in reducing markers of inflammation: 1) bleeding upon probing (BOP), 2) tissue inflammatory / anti-inflammatory gene activation (rt-PCR) and 3) corresponding gingival crevicular fluid (GCF) protein production in non-resolving 6-9 mm periodontal pockets in patients on periodontal maintenance therapy (PMT). Fifty periodontal maintenance patients diagnosed with advanced chronic adult periodontitis presenting with a 6-9 mm interproximal PD were included in study. Experimental (PR/RP+SIM; n=27) and control …

Urinary Bile Acid Indices As Prognostic Biomarkers For The Complications Of Liver Diseases, Wenkuan Li

Theses & Dissertations

Hepatobilary diseases cause the accumulation of toxic bile acids (BA) in the liver, blood, and other tissues, which may lead to an unfavorable prognosis. In this study, we compared the urinary BA profile in 257 patients with hepatobilary diseases during a 7-year follow-up period. We investigated the use of the urinary BA profile to develop logistic regression models to predict the prognosis of hepatobiliary diseases in terms of developing disease-related complications, especially for ascites. The urinary BA profile was characterized by calculating BA indices, which quantify the composition, metabolism, hydrophilicity, and toxicity of the BA profile. All patients had high …