Medicine and Health Sciences Commons^™

2021-08-30_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was downloaded as an Excel spreadsheet which appeared in the Public Use Datasets section under the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173---,00.html.

Cases are aggregated by the date of onset of COVID-19 symptoms, if known, otherwise by laboratory specimen date if known, otherwise by case referral date. Deaths are aggregated by the date of death if known, otherwise by the last date of a change to the case status.

2021-08-30_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2021-08-30_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted three times a week on Mondays, Wednesdays and Fridays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time …

2021-08-30_Michiganoverview_Covidschooloutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The School Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_102480---,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

In accordance with the Council of State and Territorial Epidemiologists’ outbreak definition, schools that have been found by their local health department to have two (2) or more COVID-19 cases who may have shared exposure at the school grounds and are not from the same household (with the exception of dorms and off-campus housing) are included. If your child’s school is …

Breathing Wildfire Smoke Can Affect The Brain And Sperm, As Well As The Lungs, Luke Montrose, Adam Schuller

Public and Population Health Faculty Publications and Presentations

Wildfires burning in the western U.S. are sending smoke into communities far from the fires themselves, creating hazardous air for days or weeks at a time. A lot of people are wondering: What does breathing all that smoke do to our bodies?

Wildfire smoke is a mix of chemicals and tiny particles that are small enough to evade the body’s defenses and directly affect the lungs. But the damage may not stop there.

As environmental toxicologists, we have been investigating the health effects of wildfire smoke on humans, including on parts of the body that you might not expect: sperm …

2021-08-30_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Alveolar Bone Loss Analysis On Dental Digital Radiography Image, Aulia Karina Fitriananda, Bramma Kiswanjaya, Hanna H. Bachtiar-Iskandar

Makara Journal of Health Research

Background: Periodontal disease is the second most common tooth and mouth disease in Indonesia. Moreover, radiographic examination is the most useful tool to evaluate alveolar bone loss and diagnose periodontal diseases. This study aimed to analyze radiographically the relationship between alveolar bone loss and age among patients with chronic periodontitis.

Methods: A total of 192 digital periapical images of patients aged 25–40 years were collected. Four regions were selected, including the maxillary and mandibular central incisors and maxillary and mandibular first molars. Alveolar bone loss was measured in the mesial and distal surfaces.

Results: The mean and …

Subtype-Selective Positive Modulation Of KCa 2 Channels Depends On The Ha/Hb Helices, Young-Woo Nam, Meng Cui, Naglaa Salem, Razan Orfali, Misa Nguyen, Grace Yang, Mohammad Asikur Rahman, Judy Lee, Miao Zhang

Pharmacy Faculty Articles and Research

Background and Purpose

In the activated state of small-conductance Ca2+-activated potassium (KCa 2) channels, calmodulin interacts with the HA/HB helices and the S4-S5 linker. CyPPA potentiates KCa 2.2a and KCa 2.3 channel activity but not the KCa 2.1 and KCa 3.1 subtypes.

Experimental Approach

Site-directed mutagenesis, patch-clamp recordings and in silico modeling were utilized to explore the structural determinants for the subtype-selective modulation of KCa 2 channels by CyPPA.

Key Results

Mutating residues in the HA (V420) and HB (K467) helices of KCa 2.2a channels to their equivalent residues in KCa 3.1 channels diminished the potency of CyPPA. CyPPA elicited …

Sonogames: Sounds Of The Right Kind Introducing Gamification Into Radiology Training, Maria Fatima Ali, Naila Nadeem, Farah Khalid, Naveed Muhammad Anwar, Ghulam Nabie, Charles Docherty

Centre for Innovation in Medical Education

Background: Radiology as compared to other fields of medicine has lagged, in incorporating modern training modalities such as gamification and simulation into its teaching curriculum.
Objective: This study aims to evaluate effectiveness of simulation-based teaching in collaboration with gamification. Bandura's conception of self-efficacy was used to provide qualitative assessment of participants' learning process through training event. Modified competitive game-based teaching methodology was utilized in an experimental study conducted for radiology residents. Workshop was divided into two sessions, first being three interactive didactic lectures followed by three competitive rounds. All participants were required to fill pre and post-self-efficacy questionnaire along with …

Restrictive Versus Liberal Transfusion Thresholds In Very Low Birth Weight Infants: A Systematic Review With Meta-Analysis, Peng Wang, Xing Wang, Haidong Deng, Linjie Li, Weelic Chong, Yang Hai, Yu Zhang

Department of Medicine Faculty Papers

BACKGROUND: To assess the efficacy and safety of restrictive versus liberal red blood cell transfusion thresholds in very low birth weight infants.

METHODS: We searched MEDLINE, EMBASE, and Cochrane database without any language restrictions. The last search was conducted in August 15, 2020. All randomized controlled trials comparing the use of restrictive versus liberal red blood cell transfusion thresholds in very low birth weight (VLBW) infants were selected. Pooled risk ratio (RR) for dichotomous variable with 95% confidence intervals were assessed by a random-effects model. The primary outcome was all-cause mortality.

RESULTS: Overall, this meta-analysis included 6 randomized controlled trials …

Use Of Internet Platforms For Information About Sensitive Teeth Among Indonesian Adults: A Cross-Sectional Study, Safira Khairina, Diah Ayu Maharani, Yasemin Yavuz, Febriana Setiawati

Makara Journal of Health Research

Background: The behavior of seeking oral health information (OHI), especially the topic of sensitive teeth (ST), among the Indonesian adult population has rarely been studied. Hence, the current work aimed to analyze the characteristics of the Indonesian adult population who reported having ST and to explore their practice of self-medication in terms of their behavior of seeking OHI on the internet.

Methods: A cross-sectional study was conducted between January and March 2021 in Indonesia. This study used a self-administered questionnaire comprising questions about sociodemographic data, oral health behavior, diet, and subjective oral health. Bivariate analysis based on a …

Artificial Intelligence Toward Personalized Medicine, Muhammad Wildan Gifari, Pugud Samodro, Dhadhang Wahyu Kurniawan

Pharmaceutical Sciences and Research

In current medical practice when a patient feels symptoms he/she would consult the doctor. The doctor then gives medication in a one-fits-all fashion. However, recent genetics studies had shown that different genetic makeup can results in different effects on medication, so the medication should be customed for every individual. The main idea of “personalized medicine” is to provide the right intervention including medication to the right patient at the right time and dose. With this approach, the medication paradigm would shift from curative to preventive. The rise of personalized medicine had been possible because the information from ever-increasing biomolecular (proteomics, …

Chemical Properties, Biological Activities And Poisoning Treatment Of Novichok: A Review, Tesia Aisyah Rahmania, Bantari Wisynu Kusuma Wardhani, Editha Renesteen, Yahdiana Harahap

Pharmaceutical Sciences and Research

Novichok is an organophosphate compound found as a nerve agent chemical weapon. However, the information about its chemical properties, biological activities, and molecular interactions in the body are still protected under the “top secret” security clearance. Novichok, with the codes A230, A232 and A234, is a compound whose structure has been successfully determined. The compound is synthesized from a precursor through a nucleophilic substitution reaction. Novichok agents are considered more potent than VX gas and can be applied in unitary and binary forms. This compound has ability for the binding with acetylcholinesterase (AChE) due to inability of acetylcholine metabolism. AChE …

Validation Method For Simultaneous Analysis Of Betamethasone Dipropionate And Retinoic Acid In Cream Formulation By Ultra High-Performance Liquid Chromatography, Supandi Supandi, Umar Mansyur, Annisa Ananda Ranie, Linda Mazroatul Ulya

Pharmaceutical Sciences and Research

A simple, precise and rapid reverse phase UHPLC-PDA method has been developed and validated for the simultaneous analysis of betamethasone dipropionate (BTM) and retinoic acid (REA) in whitening cream dosage form. The mixture of betamethasone dipropionate (BTM) and retinoic acid (REA) was separated on Phenomenex Bonclone 10 C18 (150 mm x 3.9 mm) column. All separations were performed with a Dionex 3000 Photodiode Array (PDA) detector on 240 nm and 340 nm wavelength, column temperature at 40oC, and flow rate at 1.0 ml/min. The mobile phase was methanol-acetic acid 0.1% (85:15) with pH 5. The retention times of BTM and …

The Effect Of Ethanol Extract Of Punica Granatum Linn. Leaves On Lipid Profiles Of Dyslipidemic Rat, Neng Fisheri Kurniati, Afrillia Nuryanti Garmana, Lia Nurul Sakinah

Pharmaceutical Sciences and Research

It has been reported that peel of Punica granatum has antidyslipidemic activity. The aim of this research was to investigate the antidyslipidemic activity of Punica granatum leaf. The dried Punica granatum leaves were extracted with 96% ethanol. Rats were divided into several groups, which were normal, positive control, simvastatin at a dose of 10 mg/kg bw as reference group, and Punica granatum extract at a dose of 100 mg/kg. Before treatment, male Wistar rats were fed with high cholesterol chow for 3 months, and then plant extract was given for 4 weeks. Blood samples were collected at week 0, 12, …

Improving National Health Management Information Systems: Stakeholder Views In Selected Sub-Saharan African Countries, Marie Donaldson

Dissertations and Theses

Background

Reliable, quality health information is the foundation of measurement and decision making in the health sector. Effective health management information systems can help improve the quality and coverage of health services, aid in policy development, support program implementation, and increase the likelihood that a well-trained health work force with the infrastructure and resources needed to provide appropriate health services will be properly distributed and supplied. There is widespread global agreement that data is a powerful tool. Arming Ministry of Health officials with better access to higher quality data that they know how to use can help improve health services …

Exosomes From Adipose-Derived Stem Cells Alleviate Myocardial Infarction Via Microrna-31/Fih1/Hif-1Α Pathway, Dihan Zhu, Yang Wang, Miracle Thomas, Keasiah Mclaughlin, Babayewa Oguljahan, Joshua Henderson, Qinglin Yang, Y Eugene Chen, Dong Liu

School of Graduate Studies Faculty Publications

Our previous study has revealed that exosomes from adipose-derived stem cells (ASCs) promote angiogenesis in subcutaneously transplanted gels by delivery of microRNA-31 (miR-31) which targets factor inhibiting hypoxia-inducible factor-1 (FIH1) in recipient cells. Here we hypothesized that ASC exosomes alleviate ischemic diseases through miR-31/FIH1/hypoxia-inducible factor-1α (HIF-1α) signaling pathway. Exosomes from ASCs were characterized with nanoparticle tracking analysis, transmission electron microscopy, and immunoblotting analysis for exosomal markers. Results from immunoblotting and laser imaging of ischemic mouse hindlimb revealed that miR-31 enriched ASC exosomes inhibited FIH1 expression and enhanced the blood perfusion, respectively. These effects were impaired when using miR-31-depleted exosomes. Immunohistochemistry …

Insights Into Molecular Interaction Of Flavonoid Compounds In Citrus Peel Bound To Collagenase And Elastase Enzymes: A Computational Study, Sani Ega Priani, Taufik Muhammad Fakih

Pharmaceutical Sciences and Research

Citrus peels contain various phytochemical active compounds such as flavonoids that are useful for antiaging cosmetic products. This study was conducted to identify the anti-collagenase and anti-elastase activities of flavonoid compounds in citrus peel and to determine the molecular interaction mechanism using the molecular docking method. The study was carried out through several stages, including preparation of enzyme macromolecules, preparation of flavonoid compound molecules, validation of molecular docking, identification of binding-free energy, visualization of interaction conformations, and predictions of molecular skin toxicity. The result showed that the flavonoid compounds in citrus peel (hesperidin, naringin, nobiletin, and tangeretin) could bind to …

The Lived Experiences Of Intensive Care Nursing Students Exposed To A New Model Of High-Fidelity Simulation Training: A Phenomenological Study, Celeste Marie Alfes

Faculty Scholarship

Background: In postgraduate intensive care nursing courses, high-fidelity simulation is useful to prepare students to guarantee safe and quality care of critically ill patients. Surprisingly, this issue has not attracted sufficient attention in the literature, and it is not clear whether the linear application of the traditional high-fidelity simulation method based on prebriefing, the simulation session and debriefing, can serve as empirical reference in postgraduate students’ education. The aim of this study was to investigate the lived experiences of postgraduate students receiving multiple exposures to an innovative high-fidelity simulation design based on Kolb’s Experiential Learning Theory. Methods: A phenomenological study …

Preventive Behaviors, Barriers, And Drivers Of The Covid-19 Pandemic In Malaysia: A Cross-Sectional Survey, Normaliza Ab Malik, Rusyda Helma Mohd, Nor Ba'yah Abdul Kadir

Makara Journal of Health Research

Background: Coronavirus disease 2019 (COVID-19) is a public health concern worldwide. This study aimed to assess the preventive behaviors, barriers, and drivers, including the knowledge and self-efficacy of COVID-19 in Malaysia.

Methods: A cross-sectional study was conducted during the COVID-19 outbreak by using a self-administered questionnaire. The instrument used was adopted from the World Health Organization resources. Descriptive statistics were used to describe the categorical data. Chi-square and independent t-test were performed to evaluate the associations between the variables and preventive behaviors.

Results: A total of 465 (97.3%) respondents were recorded. The mean age was 34.3 ± …

Determination Of The Nutritional Habits And Anxiety Levels In Individuals With Covid-19 In Turkey, Hatice Iskender, Eda Dokumacioglu, Osman Yalap

Makara Journal of Health Research

Background: Coronavirus disease 2019 (COVID-19), which has spread worldwide since December 2019, has infected and claimed the lives of millions of people. This study aimed to investigate the relationship between anxiety levels and nutritional habits of patients with COVID-19.

Methods: This cross-sectional study enrolled patients diagnosed with COVID-19 between February 1, 2021 and May 1, 2021. The study population included a total of 108 individuals with COVID-19 residing in Artvin, Turkey. This study used a self-administered online questionnaire, containing 40 questions from the State and Trait Anxiety Scale.

Results: The state anxiety score was 37.26, and the …

Loneliness And Health Outcomes Among Malaysian Older Adults, Siti Zuhaida Hussein, Azera Hasra Ismail, Suraya Hanim Abu Bakar

Makara Journal of Health Research

Background: Loneliness is a major social problem among the elderly all over the world.

Methods: A community-based survey was conducted among 380 community-dwelling older adults residing in Malaysia. A proportional stratified random sampling method was used to examine the relationship between health factors and loneliness. Data were collected using the short-form Social and Emotional Loneliness Scale for Adults, Geriatric Depression Scale-15, and RAND SF-20. p < 0.05 was considered to be statistically significant, and data analysis was performed using Statistical Package for the Social Sciences Statistics 26.0 for Windows.

Results: Results revealed that 32.6% of the respondents had social loneliness, 39.9% had emotional loneliness, and 9.2% had family loneliness. Bivariate analyses showed that social and emotional loneliness are significantly related to …

Prevalence And Correlates Of Frequent And Infrequent Bullying Victimization Among School Adolescents From Five Southeast Asian Countries, Karl Peltzer, Supa Pengpid

Makara Journal of Health Research

Background: Little is known about the frequency of bullying victimization (BV) among adolescents in Association of Southeast Asian Nations (ASEAN) member states. This study aims to assess the prevalence and correlates of frequent and infrequent BV among school-going adolescents in five ASEAN member states.

Methods: The cross-sectional sample of the Global School-based Student Health Survey (GSHS) of 2015 comprised 33,184 school adolescents (14.6 years mean age) from five ASEAN countries. Students completed a paper-based, self-administered questionnaire on BV in their own languages during classroom periods. Multinomial logistic regression was used to predict frequent and infrequent BV, with no …

Patient Care Delivery: Electronic Nursing Documentation In Malaysia, Siti Zuhaida Hussein, Norazilah Khalip, Rosnita Hashim, Rohaizah Harun, Nor Fazlina Fazilah, Norazilah Mat Shah

Makara Journal of Health Research

Background: The evolution of nursing documentation from paper to electronic format aims to improve patient safety and care quality. This study aimed to determine the knowledge and attitudes of registered nurses toward electronic nursing process documentation.

Methods: This cross-sectional study was conducted among 189 registered nurses who work in medical wards at a teaching hospital in Kuala Lumpur. Simple random sampling was used. Respondents’ knowledge of electronic nursing documentation was measured using a questionnaire developed by Guedes, and their attitudes toward electronic nursing documentation were measured using a questionnaire developed by Hagos. Data analysis was performed using Statistical …

The Pharyngeal Airways Of Patients With Class Ii Malocclusion: A Cone-Beam Computed Tomography Analysis, Yazgı Ay Ünüvar, Fundagül Bilgiç Zortuk, Törün Özer, Kadir Beycan

Makara Journal of Health Research

Background: This study aimed to compare the minimum axial (min Ax) area and the volumes of the nasopharyngeal (NP) and oropharyngeal (OP) airways of patients with Class II malocclusion with different sagittal positions of the mandible and maxilla and patients with Class I malocclusion with normal jaw positions.

Methods: Airway areas and volumes of 51 patients with Class I malocclusion with normal maxillary and mandibular positions (0 < ANB < 4, 84 > SNA > 80, and 82 > SNB > 78) were compared with 21 patients with Class II malocclusion with normal maxillary and retrognathic mandibular positions (ANB>4, 84>SNA>80, and SNB4, SNA>84, …

Comparative Analysis Of Proteomics Biomarkers Associated With Residual Ridge Resorption Induced By Denture Wear, Rohana Ahmad, Ainin Sofia Mohamad Napi, Tong Wah Lim, Su Keng Tan, Saiful Anuar Karsani, Musalmah Mazlan, Lay Kek Teh, Steven M. Morgano, Nadim Z. Baba

Makara Journal of Health Research

Background: The biochemical bone turnover markers for residual ridge resorption (RRR) are unclear. Therefore, the present study aimed to determine the biochemical bone turnover markers associated with RRR by comparing proteomics between the compressed mucosa of denture wearers and the non-compressed mucosa of non-denture wearers.

Methods: The mucosal specimens of 11 complete-denture wearers were obtained from the alveolar ridge during surgical implant exposure for implant-retained overdentures. All denture wearers had been edentulous and worn dentures for at least 5 years. The tissues of 11 non-denture wearers were taken from the ridge during minor preprosthetic surgery. The mucosal proteins …

Urinary Proteomics Combined With Home Blood Pressure Telemonitoring For Health Care Reform Trial: Rational And Protocol, Lutgarde Thijs, Kei Asayama, Gladys E. Maestre, Tine W. Hansen, Luk Buyse, Dong-Mei Wei, Jesus D. Melgarejo, Jana Brguljan-Hitij, Hao-Min Cheng, Fabio De Souza

School of Medicine Publications

Background: Hypertension and diabetes cause chronic kidney disease (CKD) and diastolic left ventricular dysfunction (DVD) as forerunners of disability and death. Home blood pressure telemonitoring (HTM) and urinary peptidomic profiling (UPP) are technologies enabling prevention.

Methods: UPRIGHT-HTM (Urinary Proteomics Combined with Home Blood Pressure Telemonitoring for Health Care Reform [NCT04299529]) is an investigator-initiated 5-year clinical trial with patient-centred design, which will randomise 1148 patients to be recruited in Europe, sub-Saharan Africa and South America. During the whole study, HTM data will be collected and freely accessible for patients and caregivers. The UPP, measured at enrolment only, will be …

Results Of Covid-19 Surveillance In A Large United States Pediatric Healthcare System Over One Year, Sarah E Messiah, Luyu Xie, Matthew S Mathew, George L Delclos, Harold W Kohl, Jeffrey S Kahn

Faculty, Staff and Student Publications

BACKGROUND: The lack of SARS-CoV-2 antigen surveillance testing in the pediatric population has inhibited accurate infection and hospitalization prevalence estimates. We aim to report the estimated prevalence of and risk factors for COVID-19 infection, hospitalization, and intensive care unit (ICU) admission across the three United States (US) waves in one of the largest pediatric healthcare systems in the nation.

METHODS: Retrospective electronic health record (EHR) review of all COVID-19 surveillance data among children aged 0-19 years seeking healthcare at one pediatric healthcare system that serves predominantly Medicaid-dependent families from 1 March 2020 to 31 March 2021. COVID-19 infection status (Y/N), …

Week Of August 30, 2021, New York Medical College

InTouch

• NYMC Forms Affiliation for Graduate Medical Education with Landmark Medical Center in Rhode Island
• NYMC and TCUS host 14th COVID-19 Symposium
• Campus Shuttle Resumes Operation
• Chancellor Halperin Shares his Thoughts on What Data from the 2020 U.S. Census Means for White Supremacists

Hepatitis E: Genotypes, Strategies To Prevent And Manage, And The Existing Knowledge Gaps, Lubna Kamani, Zahra Ali Padhani, Jai K. Das

Section of Gastroenterology

Hepatitis E virus (HEV) is considered an emergent source of viral hepatitis worldwide, with an increasing burden of jaundice, liver failure, extrahepatic illnesses, and deaths in developed countries. With the scarcity of data from efficient animal models, there are still open-ended questions about designing new models to study pathogenesis, types, virology, and evolution of these viruses. With an emphasis on available data and updates, there is still enough information to understand the HEV life cycle, pathogen interaction with the host, and the valuation of the role of vaccine and new anti-HEV therapies. However, the World Health Organization (WHO) and the …