Medicine and Health Sciences Commons^™

Micrornas As Biomarkers For Predicting Complications Following Aneurysmal Subarachnoid Hemorrhage, Wang-Xia Wang, Joe E. Springer, Kevin W. Hatton

Sanders-Brown Center on Aging Faculty Publications

Aneurysmal subarachnoid hemorrhage (aSAH) is a high mortality hemorrhagic stroke that affects nearly 30,000 patients annually in the United States. Approximately 30% of aSAH patients die during initial hospitalization and those who survive often carry poor prognosis with one in five having permanent physical and/or cognitive disabilities. The poor outcome of aSAH can be the result of the initial catastrophic event or due to the many acute or delayed neurological complications, such as cerebral ischemia, hydrocephalus, and re-bleeding. Unfortunately, no effective biomarker exists to predict or diagnose these complications at a clinically relevant time point when neurologic injury can be …

Accelerating The Provision Of Safe Water Supply In Urban And Rural Areas Of Indonesia, Sumengen Sutomo, Salord Sagala, Bebi Sutomo, Sri Winarti, Gelant Sanjaya

Kesmas

Over the past 100 years, the provision of a safe water supply to drink in Indonesia has been slowly progressed with low coverage. The majority of the population does not have access to safe water. Morbidity and mortality of water-related diseases, including diarrhea, are very high. The provision of safe water is not a technological issue but good water management that comprises content, institutional, and communication layer. This paper provided information for strategic and operational decisions to accelerate the provision of safe water services in urban and rural areas. Benchmarking good water management with the characteristics of the water supply …

Strategy For Diagnosing Breast Cancer In Indonesia During The Covid-19 Pandemic: Switching To Ultrasound-Guided Percutaneous Core Needle Biopsy, Farida Briani Sobri, Adang Bachtiar, Sonar Soni Panigoro, Juwita Cresti Rahmaania, Patria Wardana Yuswar, Ening Krisnuhoni, Nelly Tandiari

Kesmas

In this era of COVID-19, suspected breast cancer patients experience delay in diagnosis due to the fear of contracting the virus and reduction of non-COVID-19 health services. Furthermore, it may lead to potential increase in the incidence of advanced cancers in the future. Ultrasound-guided (US-guided) percutaneous core needle biopsy (CNB) is a great option for the diagnosis of cancer but it is poorly utilized. This study aimed to prove that the US-guided CNBis accurate when performed in a local setting and a potential solution for diagnosing breast cancer patients in this pandemic. In addition, it was a single health center …

Correlation Between Dental Environment And Perceived Stress Scale Among Dental Students During The Covid-19 Pandemic In Indonesia, Tri Erri Astoeti, Howis Josephine, Armelia Sari Widyarman, Widijanto Sudhana

Kesmas

Academic stressors in a medical educational environment are related to two factors. This study was carried out in order to analyze the correlation between the dental environment and perceived stress among dental students during the COVID-19 pandemic. The respondents were 422 undergraduate dental students and the validated Modified Dental Environmental Stress (DES) and Perceived Stress Scale (PSS) questionnaires were used. Furthermore, the Spearman correlation analysis was used to measure the correlation between DES and PSS score. The result showed that five dental stressors were noted to have the strongest correlations with PSS (p-value >0.40). They include expectation towards dental school …

Characteristics Of Cognitive Status In Sub-Population Of Sub-Acute Stage Of Ischemic Stroke Patients In West Nusa Tenggara, Indonesia, Herpan Syafii Harahap, Muhammad Akbar, Jumraini Tammasse, Andi Kurnia Bintang, Andi Alfian Zainuddin

Kesmas

Cognitive decline is a significant complication that affects most stroke survivors. Early detection of cognitive decline in ischemic stroke patients and identification of risk factors improves their clinical outcomes. This study aimed to determine the characteristics of cognitive status in the sub-acute phase of ischemic stroke. A cross-sectional study was conducted on 89 sub-acute ischemic stroke patients in three hospitals in West Nusa Tenggara recruited consecutively from August 2019 to April 2020. The data collected were demographic and clinical characteristics, cognitive status, and functional outcome. The association between clinical and demographic characteristics and cognitive decline was analyzed using logistic regression. …

Reasons For Unwanted Pregnancy Among Women Of Childbearing Age (15-19 Years) In Jambi Province, Ummi Kalsum, Renny Listiawaty, Dato Noor Aziah Mohd Awal

Kesmas

The occurrence of unwanted pregnancy (UP) among women of childbearing age (WCA) has been reported to be increasing in various regions, however, this incidence has not been assessed among the adolescents of 15-19 years age group, in Jambi City. The factors influencing this occurrence includes individual, family, and environmental determinants. This study aimed to determine the prevalence of UP among WCA (15-19 years) in Jambi Province. A cross-sectional design was used, while the participants (307 women aged 15-19 years) were selected in Jambi City and West Tanjung Jabung District, using the Multistage Random Sampling. The analytical method used was the …

Geographic Accessibility Towards Primary Health Care In Karawang District, Nabila Ramadina, Mulya Nurmansyah Ardisasmita, Budi Sujatmiko

Kesmas

Health accessibility refers to the availability of health care services accessible to the community as required. However, the convenience of accessing such services vary throughout regions due to geography. Hence differences in geographic accessibility can be an obstacle to accessing health care. This study characterized the influence of geographic accessibility on primary health care (PHC) in Karawang District. A cross-sectional study was conducted in November 2019 in five sub-districts of Karawang District. Respondents were interviewed using questionnaires to collect geographic (mileage and travel time from respondents’ house to nearest PHC) and transportation (mode of transportation and transportation cost) data. In …

King Bhumibol Adulyadej’S Sufficiency Economy Philosophy And Post-Traumatic Stress Disorder Among Higher-Education Students From The Armed Conflict Region Of Thailand, Chonnakarn Jatchavala, Arnont Vittayanont

Kesmas

This cross-sectional survey assessed the association between post-traumatic stress disorder symptoms and perceived self-sufficiency, reflecting the Sufficiency Economy Philosophy (SEP), conceived by H.M. King Bhumibol Adulyadej (King Rama IX). It was conducted among university students on one campus located within the area affected by the Southern Thailand insurgency and another campus located in a nearby province outside of the restive area. All self-administered questionnaires consisted of questions related to personal information, the Thai version of the PTSD checklist, and a questionnaire aimed at measuring the perceived self-sufficiency according to H.M. King Bhumibol Adulyadej’s SEP. The study found that most university …

Covid-19 Preparedness And The Anxiety Of Thai Citizens, Afifi Lateh, Prasopchai Pasunon, Kiflan Dolah, Panida Kongjam, Saminee Chemae, Phanupong Panomwan, Alawee Lateh

Kesmas

The outbreak of COVID-19 has brought sickness and fatality to Thai citizens. In addition, it left a tremendous psychological impact on mental health as they experienced panic and anxiety about controlling situations and preserving their physical and mental well-being. This study aimed to analyze the factors influencing COVID-19 preparedness and anxiety based on groups of Thai citizens. Online questionnaires were employed to collect data from 2,768 respondents selected through convenience sampling and snowball sampling on Facebook, having shared questionnaires with 190 other users. Data were collected from March 29 to April 3, 2020. The acquired data were analyzed using percentage …

Persistent Brainstem Abscess Requiring Repeat Microsurgical Drainage: Case Report, Wesley M. Shoap, Ellery A. Hayden, George A. Crabill

School of Medicine Faculty Publications

n this paper, we present a patient who was treated for a pontine abscess at our institution. This patient underwent sub-occipital craniotomy for microscopic abscess drainage after which cultures grew Streptococcus intermedius. She was treated with antibiotics but failed to show clinical improvement and was taken back to the operating room for repeat abscess drainage. Clinical improvement was seen after the second operation. This case report describes open surgical technique as a safe and effective way of treating brainstem abscess.

Nucleated Red Blood Cells As A Biomarker For Mortality In Neonates Following Cardiac Surgery, Kurt D. Piggott, Syeda Maqsood, Cynthia L. Warner, Timothy Pettitt, Shengping Yang, Jason Turner, Amira Soliman, Casey Norlin, Latasha Lewis, Ajay Bhatia

School of Medicine Faculty Publications

Introduction: Nucleated red blood cells (NRBCs) are immature red cells that under normal conditions are not present in the peripheral circulation. Several studies have suggested an association between elevated NRBC and poor outcome in critically ill adults and neonates. We sought to determine if elevations in NRBC value following cardiac surgery and following clinical events during the hospital stay can be used as a biomarker to monitor for mortality risk in neonates post-cardiac surgery. Materials and methods: We constructed a retrospective study of 264 neonates who underwent cardiac surgery at Children's Hospital, New Orleans between 2011 and 2020. Variables included …

Intra-Arterial Combination Therapy For Experimental Acute Ischemic Stroke, Michael E. Maniskas, Jill M. Roberts, Amanda A. Gorman, Gregory J. Bix, Justin F. Fraser

Neurosurgery Faculty Publications

Acute ischemic stroke continues to devastate millions of individuals worldwide. Current treatments work to restore blood flow but not rescue affected tissue. Our goal was to develop a combination of neuroprotective agents administered intra-arterially following recanalization to target ischemic tissue. Using C57Bl/6J male mice, we performed tandem transient ipsilateral middle cerebral/common carotid artery occlusion, followed by immediate intra-arterial pharmacotherapy administration through a standardized protocol. Two pharmacotherapy agents, verapamil and lubeluzole, were selected based on their potential to modulate different aspects of the ischemic cascade; verapamil, a calcium channel blocker, works in an acute fashion blocking L-type calcium channels, whereas lubeluzole, …

Dietary Diversity And Social Determinants Of Nutrition Among Late Adolescent Girls In Rural Pakistan, Jo-Anna B. Baxter, Yaqub Wasan, Muhammad Islam, Simon Cousens, Sajid Bashir Soofi, Imran Ahmed, Daniel W. Sellen, Zulfiqar Ahmed Bhutta

Centre of Excellence in Women and Child Health

The conditions in which adolescent girls mature shape their health, development and nutrition. Nutrient requirements increase to support growth during adolescence, but gaps between consumption and requirements exist in low- and middle-income countries. We aimed to identify and quantify the relationship between dietary intake and diverse social determinants of nutrition (SDN) among a subset of adolescent girls 15-18.9 years (n = 390) enrolled within the Matiari emPowerment and Preconception Supplementation (MaPPS) Trial. The primary outcome, dietary diversity score (DDS), was derived by applying the Minimum Dietary Diversity for Women 10-item scale to 24-h dietary recall data collected three times per …

Mechanisms Of Neurotoxicity Associated With Exposure To The Herbicide Atrazine, Sydney C. Stradtman, Jennifer L. Freeman

School of Health Sciences Faculty Publications

Atrazine is an herbicide commonly used on crops to prevent broadleaf weeds. Atrazine is an endocrine-disrupting chemical mainly targeting the neuroendocrine system and associated axes, especially as a reproductive toxicant through attenuation of the luteinizing hormone (LH). Current regulatory levels for chronic exposure are based on no observed adverse effect levels (NOAELs) of these LH alterations in rodent studies. Atrazine has also been studied for its effects on the central nervous system and neurotransmission. The European Union (EU) recognized the health risks of atrazine exposure as a public health concern with no way to contain contamination of drinking water. As …

Higher Entropy Observed In Sars-Cov-2 Genomes From The First Covid-19 Wave In Pakistan, Najia Karim Ghanchi, Asghar Nasir, Kiran I. Masood, Syed Hani Abidi, Syed Faisal Mahmood, Akber Kanji, Safina Abdul Razzak, Waqasuddin Khan, Saba Shahid, Maliha Yameen, Ali Raza, Javaria Ashraf, Zeeshan Ansar Ahmed, Mohammad Buksh Dharejo, Nazneen Islam, Zahra Hasan, Rumina Hasan

Department of Pathology and Laboratory Medicine

Background: We investigated the genome diversity of SARS-CoV-2 associated with the early COVID-19 period to investigate evolution of the virus in Pakistan.
Materials and methods: We studied ninety SARS-CoV-2 strains isolated between March and October 2020. Whole genome sequences from our laboratory and available genomes were used to investigate phylogeny, genetic variantion and mutation rates of SARS-CoV-2 strains in Pakistan. Site specific entropy analysis compared mutation rates between strains isolated before and after June 2020.
Results: In March, strains belonging to L, S, V and GH clades were observed but by October, only L and GH strains were present. The …

Knowledge And Awareness Of Dental Specialists, General Dentists And Dental Assistants Regarding Sars‑Cov‑2, Hafsa Qabool, Rashna Hoshang Sukhia, Mubassar Fida

Section of Dental-Oral Maxillofacial Surgery

Background: Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) has had drastic effects among healthcare professionals.
Objectives: This study aimed to assess knowledge and awareness among dental specialists, general dentists and dental assistants regarding standard patient care guidelines for minimizing the spread of the infection.
Material and methods: A survey-based cross-sectional study was conducted on a sample of 84 participants. The participants were divided into groups of dental specialists, general dentists and dental assistants. A modified version of a validated questionnaire was used to evaluate knowledge and awareness regarding SARS‑CoV‑2 as per the Centers for Disease Control and Prevention (CDC) guidelines. …

Unintended Consequences Of Air Cleaning Chemistry, Douglas B. Collins, Delphine K. Farmer

Faculty Journal Articles

Amplified interest in maintaining clean indoor air associated with the airborne transmission risks of SARS-CoV-2 have led to an expansion in the market for commercially available air cleaning systems. While the optimal way to mitigate indoor air pollutants or contaminants is to control (remove) the source, air cleaners are a tool for use when absolute source control is not possible. Interventions for indoor air quality management include physical removal of pollutants through ventilation or collection on filters and sorbent materials, along with chemically reactive processes that transform pollutants or seek to deactivate biological entities. This perspective intends to highlight the …

A Convergent Parallel Study On Knowledge, Perceptions, And Attitudes Of Mainstream Workers During Covid-19, Farhan Alshammari, Romeo Mostoles Jr, Eddieson Pasay-An, Sultan Alshammari

Makara Journal of Health Research

Background: This study explores and assesses the knowledge, perceptions, and attitudes of mainstream workers during the COVID-19 pandemic in the Ha’il Region, Kingdom of Saudi Arabia.

Methods: Using convergent parallel mixed-methods design, 502 frontline workers were enlisted via snowball and purposive sampling. Descriptive statistics and thematic analysis were used to analyze the quantitative and qualitative data, respectively.

Results: There is a well-prepared response to COVID-19, namely, a commendable knowledge, attitude, and practices (KAP) gap documented in reliable information concerning the virus, specifically, awareness that COVID-19 can be a potentially fatal disease (100%); that droplets from infected people …

Mammalian And Invertebrate Models As Complementary Tools For Gaining Mechanistic Insight On Muscle Responses To Spaceflight, Amber M. Paul, Thomas Cahill, Henry Cope, Joseph J. Bass, Eliah G. Overbey, Rachel Gilbert

Publications

Bioinformatics approaches have proven useful in understanding biological responses to spaceflight. Spaceflight experiments remain resource intensive and rare. One outstanding issue is how to maximize scientific output from a limited number of omics datasets from traditional animal models including nematodes, fruit fly, and rodents. The utility of omics data from invertebrate models in anticipating mammalian responses to spaceflight has not been fully explored. Hence, we performed comparative analyses of transcriptomes of soleus and extensor digitorum longus (EDL) in mice that underwent 37 days of spaceflight. Results indicate shared stress responses and altered circadian rhythm. EDL showed more robust growth signals …

Comparison Of Shaping Ability Between Continuous Rotary And Manual Instrumentations In Pediatric Endodontics, Burcu Güçyetmez Topal, Seda Falakaloğlu, Hatice Türkoğlu

Journal of Dentistry Indonesia

Objective: The aim of this in vitro study was to evaluate the efficacy of rotary EndoArt Ni-Ti Gold Pedo Kit and K-files in shaping ability, canal transportation, centering ability and instrumentation time in primary molars.

Methods: For the study total of 30 extracted primary molars root with minimum 7mm root length were selected. Shaping of root canals in primary molars were done using the two systems, and CBCT and specialized software were used for scanning and analysis of pre-operative and post-operative to evaluate the groups for their shaping properties, apical transportation and preparation time in primary root canals.

Results: No …

Cytotoxic Evaluation Of Malaysian Kelulut Honey On Human Gingival Fibroblast Cell Line Using Mtt Assay, Chee Zi Yun, Nurul Hafizah Mohd Nor, Zurairah Berahim, Kannan Thirumulu Ponnuraj

Journal of Dentistry Indonesia

Kelulut honey or stingless bee honey is a type of honey produced by stingless bees of the Trigona species where the nest is found in living trees.

Objective: The aim of this study was to evaluate the cytotoxic potential of Malaysian Kelulut honey by employing MTT assay on a human gingival fibroblast cell line.

Methods:Human gingival fibroblast cell line was cultured in minimal essential medium alpha (α-MEM) with 10% foetal bovine serum and 1% penicillin-streptomycin solution in a 5% CO2 incubator at 37°C in a humidified atmosphere. The cells were seeded at a cell density of 5x103 cells/well in …

Interrelationship Between Orthodontics And Implantology In Anterior Aesthetic Rehabilitation: A Case Report, Adailton De Morais Cavalcante, Renata Cordeiro Teixeira Medeiros, Danilo Lopes Ferreira Lima, Saulo Ellery Santos

Journal of Dentistry Indonesia

The rehabilitation of complex cases in the anterior region of the maxilla may require knowledge of several dental specialties. when dental involvement also causes bone and gingival involvement, management usually requires adjustment of gingival zenitis and bone graft to compensate for bone loss.

Objective: to discuss a case of previous orthodontic treatment for implant-prosthetic rehabilitation in the anterior region.

Case report: This case report describes a 40-year-old patient who came with the intention of extracting the tooth and installing a bridge. The implant-prosthetic treatment was performed after previous orthodontic treatment to adapt the gingiva and space.

Conclusion: The interrelationship of …

Evaluation Of The Relationship Between Sella Turcica Bridging And Dental Anomalies, Ahmet Karaman, Saadet Cinarsoy Cigerim Assistant Professor, Nourtzan Kechagia Research Assistant

Journal of Dentistry Indonesia

Objectives: This study aims to evaluate the relationship between the morphological variations of Sella Turcica (ST) and dental anomalies.

Methods: This study included 765 individuals between the ages of 13 and 35. ST morphology was examined in 3 groups as no calcification, partially calcified and completely calcified according to the interclinoid ligament (ICL) on lateral cephalometric films, and it was examined and evaluated in terms of its relationship to impacted canines (unilateral and bilateral), impacted teeth (except 3rd molars), root dilaceration, tooth deficiency (upper incisor lateral - lower and upper second premolar), supernumerary tooth and taurodontism.

Results: The rates of …

Holistic Management For Severe Oral Lichen Planus: A Case Report, Nik Mohd Mazuan Nik Mohd Rosdy, Nyi Mas Siti Purwaningsih

Journal of Dentistry Indonesia

Oral lichen planus (OLP) is an immunologically mediated mucocutaneous disease associated with various factors including systemic diseases, with a higher prevalence in females than males. The majority of OLP cases are accompanied by symptoms of discomfort and/or pain. Treatment of OLP can be challenging due to its unknown aetiology and involvement of multiple contributing factors.

Objective: Our aim is to report a long-term follow-up case of oral lichen planus with holistic management approach. This report will provide some options to clinicians who are having difficulties in managing OLP cases especially with the medications.

Case Report: This case report discusses a …

Evaluation Of The Bone Thickness Of Mandibular Molars Using Cone Beam Computed Tomography, Deniz Yanık, Ahmet Mert Nalbantoglu

Journal of Dentistry Indonesia

Objective: To investigate buccal and lingual bone thicknesses and fenestration rate of mandibular first and second molars using cone-beam computed tomography (CBCT).

Methods: A total of CBCT images of 41 patients were selected and overall 120 mandibular molars were investigated. The buccal and lingual alveolar bone widths were measured at apex of the roots. The prevalence of fenestration in mandibular molars was recorded. Statistical analyses were performed.

Results: The buccal bone widths of mesial root of second molars were significantly lower than the lingual (p<0.05). The lingual bone widths of mesial and distal root of second molars were lower than the buccal (p<0.05). The lowest thickness of buccal and lingual bone was observed in mesial root of first molar and distal root of second molar. The prevalence of fenestration in mandibular first and second molars was 5% and 10%.

Conclusion: The buccal bone widths were lower at the first molar than the second molar. …

Effect Of Natural And Industrial Juices On Surface Microhardness Of Microhybrid And Nanohybrid Composites, Razieh Meshki, Hanieh Hoseini

Journal of Dentistry Indonesia

Numerous studies have been conducted on the effect of various beverages on the mechanical properties of tooth-colored materials, however, little is known about the effects of these materials on composites, particularly newer types such as nanocomposites.

Objectives: This study aimed to evaluate the surface microhardness of two types of composites, micro-hybrid (point 4) and nanohybrid (premise), after exposure to natural and industrial juices.

Methods: In this experimental study, 90 disc-shaped specimens with a thickness of 2 mm and a diameter of 10 mm were taken from two composites, micro-hybrid Point4 (Kerr) and nanohybrid premise (kerr) (two groups of 45). Then, …

Approaches Of General And Specialist Dentists To Deep Caries Management: A Cross-Sectional Study From Turkey, Ebru Delikan, Ayşe Tuğba Ertürk-Avunduk, Seçkin Aksu

Journal of Dentistry Indonesia

Objective: To determine the differences in treatment strategies and material preferences for deep dentine carious lesions (DDCLs) management among general and specialist dentists.

Methods: Dentists working in universities, oral and dental health centers, or private practice were administered a 14-item web-based questionnaire regarding demographic and occupational characteristics, approaches to DDLCs, pulp capping methods, and preferences for restorative materials. The data were examined using descriptive statistical analysis and Pearson’s chi-square tests.

Results: The study enrolled 298 general and 265 specialist dentists among whom 67.1% were female and 73.3% were aged 25 to 35 years. Total excavation and permanent restoration of DDCLs …

Assessment Of The Working Posture Among Dental Students To Prevent Musculoskeletal Disorders, Eleena Mohd Yusof, Muhamad Amir Hazim Razli, Siti Aisyah Iman Mohd Nasir

Journal of Dentistry Indonesia

Poor working posture among dental practitioners has been known to cause musculoskeletal disorders (MSDs), which are made worse by lengthy procedures and a lack of awareness about the proper working posture.

Objectives: To assess the working posture of clinical dental students to determine if interventions were needed to reduce MSDs.

Methods: The working postures of 225 clinical dental students were recorded and assessed within 10 minutes into procedures from March-December 2019, using the Rapid Upper Limb Assessment (RULA) method. The results were then statistically analysed using chi-square and Fisher’s exact tests.

Results: Of the 225 students observed, 64 (28.4%; 95% …

Maxillary Implant Placement In A Limited Residual Bone Height, Calvin Kurnia, Jane Amelia V. Wibisono, Dominica Dian S. Sumantri

Journal of Dentistry Indonesia

The limitation of residual bone height (RBH) and vital structures such as sinuses in the maxillary often make the implant placement procedure becomes complicated. Clinicians may perform sinus elevation prior to implant placement to accommodate the length of the implant fixture. Sinus elevation is an invasive procedure and complication may occur during the surgery including the most frequent complication is perforation of Schneiderian membrane.

Objectives: To discuss a comprehensive management of implant placement and its complication step by step from surgical procedures to crown placement.

Case Report: 67-year-old female patient with partial edentulism in the right maxillary region, presence of …

Telemedicine Visits In An Established Multidisciplinary Central Nervous System Clinic For Radiation Oncology And Neurosurgery (Radians) In A Community Hospital Setting., S C Bowen R, R Gheewala, Wa Paez, B Lucke-Wold, T Mitin, Jn Ciporen

Clinical Research and Leadership Faculty Publications

OBJECTIVE: To determine the impact of telemedicine visits, compared to in-person visits, on patient satisfaction in an established community hospital-based multidisciplinary central nervous system (CNS) clinic.

METHODS: Telemedicine options - virtual visits and teleconferencing - were introduced in July 2020. Both radiation oncologist and neurosurgeon were simultaneously present for the telemedicine visit. Descriptive patient demographics, survey responses, and travel time and distance calculations were analyzed. Satisfaction score was compared to previously published data.

RESULTS: A total of twenty-five telemedicine visits (n=22 video; n=3 phone) were completed since July 2020. Patient demographics are as follows: mean age was 59 years (range=22-81), …