Medicine and Health Sciences Commons^™

Evaluation Of Poly (Ethylene Glycol–Propylene Glycol) Copolymer Bone Hemostatic Agent Containing Gentamicin For Enhancing Local Antibacterial And Anti-Inflammatory Effects In An Infected Calvarial Defect Rat Model, Jeon-Mo Kim, Hun-Young Yoon

The Thai Journal of Veterinary Medicine

Bone wax is the most commonly used hemostatic agent in surgery; however, it is non-absorbable and may act as a nidus of infection. Thus, new hemostatic agents that are absorbable and have antibiotic effects are needed. In this study, we assessed the hemostatic ability, bioabsorption, and local antibiotic and anti-inflammatory effects of a newly developed poly(ethylene glycol–propylene glycol) (PEG-PPG) copolymer containing gentamicin (PEG-PPGg) in a calvarial defect rat model. A total of 100 Sprague Dawley rats were used in this study. Twenty were used to determine time to hemostasis and bioabsorption of PEG-PPGg. The remaining rats were assigned to four …

The Efficiency Of Herbal On Blood Clotting And Wound Healing Of Ear Notched Pigs, Kittiphong Tippaya, Ruttayaporn Ngasaman, Kridda Chukiatsiri

The Thai Journal of Veterinary Medicine

This study aimed to determine the efficiency of Jatropha podagrica Hook. f., Chromolaena odorata (L.) and Centella asiatica (L.) on the reduction of blood clotting and promoting wound healing in notched piglets. Thirty-four notched piglets aged 2–3 days were selected for applying fresh exudes of J. podagrica Hook. f. to the right ear and povidone iodine to the left ear as a control. In the experiment of C. odorata (L.) and C. asiatica (L.), fifty notched piglets were divided into five groups and 10, 20, 30, 40 and 50% each of herbal gel was applied to the right ear and …

Fluid Resuscitation With Ringer’S And Trometamol-Balanced Solutions In A Rat Septic Model, Wen-Ting Ting, Chih-Hsien Wang, Yih-Sharng Chen, Jih-Jong Lee

The Thai Journal of Veterinary Medicine

Resuscitation solution is one of the main interventions provided for septic shock patients, although there is no general consensus regarding the optimal type of solution. Therefore, a trometamol-balanced solution (TBS) was designed as a resuscitation solution. The aim of this study is to assess the effects of TBS versus Ringer’s solution (RS) in a rat septic model. Septic shock was induced in 16 male Wistar-Kyoto rats through lipopolysaccharide (LPS) induction; these rats were assigned at a ratio of 1:1 to RS and TBS groups. Blood examinations were performed using an Abbott i-STAT analyzer with CG4+ (for pH, pressure of carbon …

Major Bacterial Pathogens Of Bovine Respiratory Disease And Lung Lesions In Calves From Selected Areas Of Ethiopia, Mirtneh Akalu, Behadra Murthy, Takele Abayeneh, Esayas Gelaye

The Thai Journal of Veterinary Medicine

Bovine respiratory disease (BRD) is a potential threat and an economically detrimental disease of calf-rearing in Ethiopia. This study was designed to isolate the major bacterial pathogens associated with respiratory disease of calves and the lung lesions involved. A crosssectional study with a purposive sampling method was employed in 170 calves during the study period from April 2018 to October 2018. The Bacteriological and molecular assay revealed overall isolation of 156 (91.76%) bacterial pathogens. Gross inspection of pneumonic lungs revealed one or more lesions of hydatidosis (46.67%), emphysema (44.44%), congestion (35.56%), hemorrhage (20.0%) and atelectasis (15.56%). Bacterial pathogen identification showed …

The Effects Of Endometrial Epithelium-Derived Exosomes On The Recruitment And Activation Of T Lymphocytes In The Uteri Of Dairy Cows, Hong An, Zhe Shi, Bofan Fu, Xinxin Yao, Hemin Ni, Yong Guo, Longfei Xiao, Xiangguo Wang

The Thai Journal of Veterinary Medicine

Endometritis is caused by endometrial cell injury and chronic inflammation of uteri infected by pathogens, leading to reproductive failure in dairy cows. Changes of the endometrial immune response regulates the development of endometritis. In a recent discovery, exosomes acted as a functional regulator secreted by a variety of cells, however, its regulatory mechanism in the local immune response of the uteri is still unclear. In this study, flow cytometry was performed to identify the increased number of T lymphocytes, namely Tc cells, in the uteri with endometritis while the Th and Treg cells decreased very significantly. Moreover, the functional marker …

The Feasibility And Image Quality Of Using Soft Embalming Cadaver Dogs And Cats For Radiographic And Ultrasonographic Training, Chutimon Thanaboonnipat, Nan Choisunirachon, Chalika Wangdee, Srireepong Kiertkrittikhoon, Voraphan Na Songkhla, Sirakarnt Dhitavat, Chanyaratt Chaichareonchon, Lampetch Vimuktalop, Kiatpichet Komin

The Thai Journal of Veterinary Medicine

Diagnostic imaging techniques, especially radiography and ultrasonography, have been applied as routine diagnostic tools in clinical practice of both human and veterinary medicine. Soft embalmed cadavers by Thiel’s method is a new method for preserving dead bodies that has been increasingly used in medical education especially in diagnostic imaging fields. The aims of this study were, first, to examine the feasibility of using canine and feline soft cadavers in radiographic and ultrasonographic study and training. Second, to evaluate the procedure score and image quality score of radiography and ultrasonography using the soft cadaver dogs and cats as the model. All …

Cryopreservation Methods Of Thai Native Chicken (Pradu-Hangdum) Semen: Effect Of Different Freezing Containers On Motion And Kinetic Parameters Of Frozen-Thawed Sperm, Chakorn Khunkaew, Prapas Patchanee, Sasithorn Panasophonkul, Zubing Cao, Yunhai Zhang, Anucha Sathanawongs

The Thai Journal of Veterinary Medicine

Artificial Insemination (AI) programs using qualified semen are designed to revolutionize the poultry farming sector by targeting genetic improvement along with appropriate health strategies. Hence, a prolonged preservation method of quality sperm conserves is important for successful AI outcomes. The objective of this study was to compare the effects of different type of containers; straw, cryovial tubes and pellet on the quality of the frozen-thawed Thai native chicken (Pradu-hangdum) semen. High-quality pooled semen was collected and divided into 4 groups with 12 replicates: semen preserved with BHSV extender in 1) 0.25 mL straw, 2) 0.5 mL straw, 3) 2 mL …

Uplc-Qtof/Ms-Based Metabolomic Analysis Of Plasma Reveals Altitude Effects On Yaks (Bos Grunniens), Xiangqiong Meng, Juan Zhou, Juan Zhou, Ruidong Wan, Hongxian Yu, Qing Wei

The Thai Journal of Veterinary Medicine

The yak is an ideal animal model for the study of adaptation to hypoxia at high altitudes. Its blood metabolites are an important reference index for research regarding adaptation to high-altitude hypoxia and can reflect cellular activity, antioxidant capacity and the metabolic capacity of yaks, thus highlighting the adaptability of the yak to hypoxic environments. The aim of our study was to evaluate differences in the global metabolic profiles of plasma in high- and low-altitude yaks (average age: 3 years old; live weight (LW): 300 ± 50 kg) using untargeted metabolomics. 52 differential metabolites were identified; 13 metabolites such as …

Association Of Clinical Parameters And A Formula For Predicting The Total Antioxidant Power In Cats, Kanissarinn Sakundech, Worapol Aengwanich

The Thai Journal of Veterinary Medicine

The objective of this study was to investigate external appearances, vital signs, hematological parameters, malondialdehyde and total antioxidant power to find correlations and to predict total antioxidant power in cats. Body condition scores, mucous membrane color scores, heart rate, respiratory rate, body temperature, hematological parameters, malondialdehyde and ferric reducing antioxidant capacity of 27 cats were measured. Correlation and multiple regression models were analyzed. The results revealed the following information: respiratory rate vs. heart rate, packed cell volume vs. hemoglobin, total red blood cell vs. packed cell volume, total red blood cell vs. hemoglobin, mean corpuscular hemoglobin vs. mean corpuscular volume, …

Diagnostic Value Of C-Reactive Protein And Soluble Urokinase Plasminogen Activator Receptor In Canine Monocytic Ehrlichiosis, Songul Erdogan, Onur Basbug, Ugur Aydogdu, Serdar Pasa, Hasan Erdogan, Kerem Ural

The Thai Journal of Veterinary Medicine

Canine monocytic ehrlichiosis is a vector-borne disease that can induce renal failure in dogs. In this study we aimed to describe the potential diagnostic efficiency of CRP and suPAR in dogs infected with E. canis and the association between suPAR and CRP with renal failure. For this purpose, the study consisted of a total of 17 dogs, 8 of infected with E. canis and 9 of healty. For evaluating renal failure, plasma urea-creatinine and UPC were determined and also measurements of plasma CRP and suPAR were analysed with ELISA test kits. Mean CRP, suPAR, urea, creatinine and UPC levels of …

Dynamics And Evolution Of Genotype 1 Porcine Reproductive And Respiratory Syndrome Virus Following Its Introduction Into A Herd Concurrently Infected With Genotypes 1 And 2, Thitima Tripipat, Kepalee Saeng-Chuto, Adthakorn Madapong, Christopher James Stott, Angkana Tantituvanont, Pavita Kaewprommal, Jittima Piriyapongsa, Dachrit Nilubol

The Thai Journal of Veterinary Medicine

This study was conducted to investigate the dynamics and evolution of porcine reproductive and respiratory syndrome virus (PRRSV) genotype 1 following its introduction into a herd concurrently infected with both PRRSV genotypes. The results demonstrated that 2 novel genotype 1 groups emerged, termed clusters II and III. The emergence of cluster II suggested that this cluster of genotype 1 virus potentially correlated with the outbreak. Then, cluster III was detected with the disappearance of cluster II. The evolution of the genotype 1 virus from cluster II to cluster III is likely to be associated with immune evasion induced by amino …

Immunostimulatory Effect Of Disinfectant On Bees, Tatiana Romanishina, Svitlana Guralska, Tetiana Kot, Svitlana Furman, Oleh Pinsky, Diana Feshchenko, Zhanna Rybachuk, Olexiy Tkachenko, Olga Zastulka, Svitlana Tushak

The Thai Journal of Veterinary Medicine

The article presents a modern interpretation of the immunostimulatory effect of the disinfectant “Biocontact Plus” on the bee organism. The minimum threshold concentrations of the disinfectant with bactericidal effect were determined in vitro. The stimulating effect of 0.15 % of the concentration of active substances of the disinfectant has been confirmed in vivo. The immunostimulatory effect of this concentration on the immune status of bee colonies is interpreted (the number of young and mature immunocytes). The immunomodulatory effect of 0.15 % disinfectant “Biocontact Plus” on bee haemolymph allows for the use of alternative therapies for bacterial diseases of bees in …

Comparison Of The Postoperative Outcome Of The Three-Port Laparoscopic Ovariectomy And Conventional Open Ovariectomy Methods In Dogs, Damla Tuğçe Okur, Bülent Polat

The Thai Journal of Veterinary Medicine

The aim of this study is to determine the effects of laparoscopic ovariectomy (LOVE) and conventional open ovariectomy (COVE) methods on early-stage surgical stress parameters [proinflammatory cytokines (TNF-α and IL-6), acute phase proteins (CRP, Hp), inducible nitric oxide synthase (INOS), mitogen activated protein kinase (MAPK14) and cortisol], pain scores and D-Dimer (DD) levels in 36 healthy bitches. Three-port laparoscopic ovariectomy was performed on the LOVE group while routine ovariectomy was performed on the COVE group. Surgical stress parameters and pain scores (University of Melbourne pain scale) were assessed during the pre- (0 hour) and postoperative periods (1st, 3rd, 6th hour …

Schirmer Tear Test 1 As A Method To Measure Tear Production Value In Normal Kintamani Dogs, Steven Dwi Purbantoro, Erika Kadek Yudha Ariawan, Endah Rahmawati, Zefanya Christiani, Sri Kayati Widyastuti

The Thai Journal of Veterinary Medicine

Keratoconjunctivitis sicca (KCS) is a dry eye condition due to an inadequacy of the eyes to produce tears. This condition can be diagnosed using the Schirmer Tear Test 1 (STT1). The Kintamani dog, a Chinese Chow Chow-derivate, is now popular globally to be kept by dog lovers. This study aims to determine the normal value of tear production in Kintamani dogs. Forty eyes from above one-year-old twenty Kintamani dogs were used in this study. Tear production value was measured using STT1 strip. The result showed that the mean of tear production in Kintamani dogs was 23.37±4.415 mm/min. Statistically, there was …

Systemic Aspergillosis Involving The Mediastinum Associated With Antifungal Therapy In A Dog, Nawat Sannamwong, Saikaew Sutayatram, Nardtiwa Chaivoravitsakul, Patharakrit Teewasutrakul, Sawang Kesdangsakonwut, Chollada Buranakarl

The Thai Journal of Veterinary Medicine

A four-year old, intact female Labrador Retriever dog was presented with a history and clinical signs of vomiting, anorexia and mild dyspnea. Further laboratory examination, by specific canine pancreatic lipase (cPL) test kit and abdominal ultrasound, indicated acute pancreatitis. Results from thoracic radiography and computerized tomography scan showed masses in the cranial and middle mediastinal areas. A cytology examination revealed pyogranulomatous inflammation with the presence of fungal hyphae whereas Aspergillus niger was isolated and identified. Systemic aspergillosis was diagnosed. Many antifungal drugs were introduced and the clinical outcomes were discussed with careful consideration.

Reversible Pulmonary Hypertension Secondary To Bronchopneumonia In A Kitten, Jidapa Tosuwan, Sirilak Disatian Surachetpong

The Thai Journal of Veterinary Medicine

A five-month-old Siamese kitten was presented with acute respiratory distress. The kitten had respiratory acidosis. The result of the feline N-terminal prohormone of brain natriuretic peptide (NT-proBNP) test kit was abnormal. Thoracic radiography revealed patchy lung infiltration and cardiomegaly. Severe right heart enlargement and an intermediate probability of pulmonary hypertension were suggested from echocardiography. Pulmonary hypertension secondary to severe pneumonia was suspected. The kitten was treated with oxygen supplementation, antibiotics and pimobendan. The clinical signs, radiography and echocardiography returned to normal after 30 days of treatment.

Expandable Intravertebral Implants: A Narrative Review On The Concept, Biomechanics, And Outcomes In Traumatology., Diogo L Moura, Josue P Gabriel

Surgery Articles

Expandable intravertebral implants are self-expanding devices applied percutaneously by the posterior transpedicular approach. These devices introduce the concept of anatomical restoration of vertebral body endplates and direct anatomical reduction performed from the interior of the vertebral body with a compression fracture. This paper aims to provide a narrative review on the concept, indications, biomechanical characteristics, as well as functional and radiographic outcomes of the main expandable intravertebral implants currently available, in terms of their application to thoracolumbar spine traumatology. To this end, we performed a search in July 2021 on the MEDLINE/PubMed platform with the words "expandable intravertebral implant", "armed …

Iatrogenic Acid-Induced Gingival Recession During Crown Cementation: A Case Report, Vrisiis Kofina, H. An, Swati Y. Rawal

School of Dentistry Faculty Research and Publications

Accidental contact of various chemicals in dentistry may cause damage to the gingiva. A male patient presented for a full mouth rehabilitation with ceramic crowns. The patient underwent the steps of ceramic crown preparation uneventfully. At the time of crown delivery, cotton rolls were placed in several vestibular areas for isolation. They were regularly changed during different steps of etching and cementation process, which included the use of Multilink Primer B (Ivoclar Vivadent™). On removal of the cotton roll in the area of upper right canine, the gingival tissues appeared blanched and grayish white. The cotton roll was found to …

Oral Manifestations Of Syphilis: A Review Of The Clinical And Histopathologic Characteristics Of A Reemerging Entity With Report Of 19 New Cases, Molly Housley Smith, Richard J. Vargo, Elizabeth Ann Bilodeau, K. Mark Anderson, Anna Trzcinska, Carleigh R. Canterbury, John E. Fantasia, Yeshwant B. Rawal

School of Dentistry Faculty Research and Publications

Background

Syphilis is a sexually-transmitted infectious disease caused by Treponema pallidum. Cases of primary and secondary syphilis are on the rise in the United States, with a 14.4% increase in new cases noted from 2017 to 2018 and an escalation of 71% between the years 2014 and 2018. Fulfilling its nickname of “the great imitator,” oral manifestations of syphilis may mimic a variety of infectious, neoplastic, or immune-mediated processes, both clinically and histopathologically. This large spectrum of appearances can create a diagnostic challenge to the clinician and/or pathologist, leading to delay in diagnosis or misdiagnosis.

Methods

A database of …

A Phase 1 Study Evaluating Rovalpituzumab Tesirine In Frontline Treatment Of Patients With Extensive-Stage Sclc, Christine L. Hann, Timothy F. Burns, Afshin Dowlati, Daniel Morgensztern, Patrick J. Ward, Martina M. Koch, Chris Chen, Carrianne Ludwig, Maulik Patel, Halla Nimeiri, Philip Komarnitsky, D. Ross Camidge

2020-Current year OA Pubs

INTRODUCTION: Rovalpituzumab tesirine (Rova-T) is an antibody-drug conjugate targeting DLL3, a Notch pathway ligand highly expressed on SCLC cells. Rova-T was evaluated alone or in combination with platinum-based chemotherapy (cisplatin or carboplatin combined with etoposide [CE]) in frontline treatment of extensive-stage SCLC.

METHODS: One cycle of CE pre-enrollment was permitted (later mandated). The following four cohorts were enrolled: Rova-T monotherapy (0.3 mg/kg, every 6 [q6] wk × 2; cohort 1; n = 4); Rova-T induction (0.3 mg/kg, q6 wk × 2) followed by CE every 21 days (q21) × 4 (cohort 2; n = 5); Rova-T (0.1 or 0.2 mg/kg, …

Caudal Epidural Steroid Injections In The Setting Of Remaining On Antithrombotics: A Retrospective Study., Jeremy I Simon, Jeffrey Gehret, Eric S Larsen, Kyle Hummerston, Do, Philip J. Koehler Iii, Do, Paul Kitei, Md

Rothman Institute Papers

BACKGROUND: The American Society of Regional Anesthesia currently recommends ceasing antithrombotic medications for all spinal epidural steroid injections, however there is a paucity of data on the true risk of spinal epidurals via various approaches versus the risk of cessation of an agent as it relates to the underlying medical condition.

OBJECTIVE: This study evaluated the complication rate of caudal epidural steroid injections in patients who remain on antithrombotic medications.

STUDY DESIGN: Retrospective chart review.

SETTING: Physiatric Spine Clinic in Orthopedic Specialty Office and Surgical Center.

METHODS: A retrospective chart review was performed identifying patients (n = 335) who received …

An Exploration Into Public Health Experiences Of Rural Residents To Facilitate Understanding Of Chronic Poor Health Habits: A Phenomenological Study, Marybeth E. Mitcham

Doctoral Dissertations and Projects

The purpose of this hermeneutic phenomenological study was to interpret the public health education experiences of rural residents in one predominantly rural county. This county was identified by its pseudonym, Middlesex County, for the purposes of this paper. The research was done to identify causal factors contributing to the problem of non-compliance exhibited by many rural residents. The non-compliance has resulted in many of those residents choosing to not implement beneficial practices and information from public health education. The guiding behavioral theory for this study was Maslow’s behavioral theory of a hierarchy of needs. This theory describes the rationale behind …

Managing Health Locus Of Control In Patient-Provider Relationships, James Wallace

USF Tampa Graduate Theses and Dissertations

Patient locus of control is a strong determinant of health outcomes, yet health care professionals do not typically address it in care plans. In fact, management of most medical conditions is hindered because the treating physician has little information about the patient’s locus of control. This research addresses the question “How can locus of control be used to enable health care practitioners to improve medical outcomes?”

Research Methodology. Using an engaged scholarship approach incorporating the Elaborated Action Design Research methodology, the research drives the guided, emergent design of a novel protocol and two separate artifacts for management of health locus …

Residency Training On The Frontlines Of The Covid-19 Pandemic - A Qualitative Study From Tanzania, Mariam Noorani, Hussein Manji, Elizabeth Mmari, Samina Somji, Nahida Z. Walli, Sherin Kassamali, Shabbir Adamjee, Nancy Matillya, Hanifa Mbithe, Aliasger Nagri, Neelam Ismail

Paediatrics and Child Health, East Africa

Introduction: the Coronavirus Disease 2019 pandemic has affected residency training globally. The aim of this study was to understand how the pandemic affected teaching and learning in residency programs in low resource settings where residents and faculty were working on the front line treating patients with the disease.

Methods: this qualitative study enrolled residents and faculty from the Aga Khan University in Tanzania who were providing front line care during the pandemic. Purposeful sampling was used and data was collected using focus group discussions and in-depth interviews between August and September 2020. Analysis was done using qualitative content analysis.

Results: …

A Baker's Dozen Of Top Antimicrobial Stewardship Intervention Publications In 2020, Sarah B. Green, Kayla R. Stover, Katie Barber, Jeannette L. Bouchard, Matthew L. Brown, Connor R. Deri, Bailey J. Francis, Timothy P. Gauthier, Jillian E. Hayes, Ashley H. Marx, Edoabasi U. Mcgee, Krutika Mediwala, Rachel J. Musgrove, Douglas Slain, Stefanie A. Stramel, Christopher M. Bland, P Brandon Bookstaver

Faculty Publications

The number of articles related to antimicrobial stewardship published each year has increased significantly over the last decade. Keeping up with the literature, particularly the most innovative, well-designed, or applicable to one's own practice area, can be challenging. The Southeastern Research Group Endeavor (SERGE-45) network reviewed antimicrobial stewardship-related, peer-reviewed literature from 2020 that detailed actionable interventions. The top 13 publications were summarized following identification using a modified Delphi technique. This article highlights the selected interventions and may serve as a key resource for teaching and training, and to identify novel or optimized stewardship opportunities within one's institution.

Duration Of Cessation Of Smoking Before Elective Surgery: Impact On Intraoperative Hemodynamics And Early Postoperative Pain In Developing Country, Mohsin Nazir, Gauhar Afshan, Muslima Ejaz, Amir Raza

Department of Anaesthesia

Aim and Background: It is estimated that up to 20% of patients coming for elective surgery are smokers and carry a risk of perioperative complications. Though smoking cessation and its impact on perioperative outcome are widely investigated worldwide we were unable to find any data in Pakistan. The objective of the study is to determine the impact of the duration of smoking cessation before elective surgery on intraoperative hemodynamics and postoperative pain in Pakistani population.
Methods: It was a prospective cohort study conducted at the Aga Khan University Hospital Karachi, Pakistan, for one-year duration. A total of 260 patients scheduled …

High Shear Stress Enhances Endothelial Permeability In The Presence Of The Risk Haplotype At 9p21.3, Evan L. Tang, Evan M. Masutami, Benjamin Yeoman, Jessica Fung, Rachel Lian, Brenda Ngo, Aditya Kumar, Jesse K. Placone, Valentina Lo Sardo, Adam J. Engler

Physics & Engineering Faculty Publications

Single nucleotide polymorphisms (SNPs) are exceedingly common in non-coding loci, and while they are significantly associated with a myriad of diseases, their specific impact on cellular dysfunction remains unclear. Here, we show that when exposed to external stressors, the presence of risk SNPs in the 9p21.3 coronary artery disease (CAD) risk locus increases endothelial monolayer and microvessel dysfunction. Endothelial cells (ECs) derived from induced pluripotent stem cells of patients carrying the risk haplotype (R/R WT) differentiated similarly to their non-risk and isogenic knockout (R/R KO) counterparts. Monolayers exhibited greater permeability and reactive oxygen species signaling when the risk haplotype was …

School-Based Sex Education In The United States And Its Association With Sexual And Reproductive Health Outcomes, 2000-2020, Priscilla M. Lopez

Dissertations and Theses

Background: There are significant sexual and reproductive health disparities in the United States (US). A significant proportion of sexual health disparities among adolescents is likely due in-part to inadequate school-based sex education. Sex education encourages sustainable and informed sexual behavior and has the potential reach adolescents prior to sexual debut and throughout the years at highest risk for adverse sexual health outcomes. However, the way in which sex education is defined and operationalized, as described in the literature, varies substantially, which may lead to wide variation in implementation in schools and this might explain the disparities seen. State-level sex …

A Rare Case Of Thiamine Responsive Megaloblastic Anemia Presenting With Seizures, Waleed Shahzad, Tehmina Inayat, Mansoor Iqbal, Muhammad Hassan, Fibhaa Syed, Naveed Ullah Khan, Mazhar Badshah

Pakistan Journal of Neurological Sciences (PJNS)

Thiamine responsive megaloblastic anemia (TRMA) also known as Rogers syndrome is a rare entity inherited as an autosomal recessive disorder. It consists of a pentad of diabetes-mellitus, megaloblastic anemia, thrombocytopenia, leukopenia and sensory-neural hearing loss. The defect occurs due to mutations in SLC19A2 gene resulting in the deficiency of a thiamine transporter proteins which prevents the transport of thiamine in to the cells and tissues. Here we report a 13 year old boy with megaloblastic anemia, sensory-neural deafness and young onset diabetes mellitus who presented with generalized tonic-clonic seizures. Diagnosis was based on clinical features and a rapid response to …

Effects Of Intermittent Fasting On Cognition And Neurodegeneration, Dureshahwar Kanwar, Mohammad Wasay

Pakistan Journal of Neurological Sciences (PJNS)

Intermittent fasting (IF) can facilitate neurodegenerative, neuroadaptive and neuroprotective processes leading to profound effects on cognition and dementias. The impact that IF has on the central nervous system is still not fully known. Several factors come into likely effect including changes in energy metabolism, oxidative damage, insulin sensitivity, inflammation, and functional changes related to various neurotransmitters and hormones. During IF ketones are produced in large quantities and the brain consumes these for energy. The presence of ketone bodies increases the expression of the genes for brain derived neurotrophic factor which has a powerful effect on dementia and cognition. Brain derived …