Medicine and Health Sciences Commons^™

Non-Compliance To Social Distancing During Covid-19 Pandemic: A Comparative Cross-Sectional Study Between The Developed And Developing Countries, Faiqa Binte Aamir, Syeda Maria Ahmad Zaidi, Saadia Abbas, Syed Roohan Aamir, Syed Nauman Ahmad Zaidi, Karishma Kanhya Lal, Syeda Sadia Fatima

Medical College Documents

Background: Despite mass vaccination campaigns, the world has seen a steady rise in the number of SARS-CoV-2 cases, with 178,765,626 cases and 3,869,994 COVID-19 related deaths by June 19^th, 2021. Therefore, it is important to enforce social distancing to control its spread. With the variation observed in the severity of the pandemic in different countries, it is also imperative to study the social distancing behaviors amongst the population in developed and developing countries.
Design and Methods: In this cross-sectional study, a total of 384 participants from 14 different countries were surveyed via an online REDCap form.
Results: In …

Provider Experiences Of Virtual Reality In Clinical Treatment, Christine Vincent, Margaret Eberts, Tejal U. Naik, Victoria Gulick, C. Virginia O'Hayer

Department of Medicine Faculty Papers

Background: Virtual reality (VR) has proven effective in the treatment of specific phobias and trauma particularly when in-vivo exposure therapy might be costly (e.g. fear of flying, combat scenes). Similarly, VR has been associated with improvement of chronic pain and of acute pain during medical procedures. Despite its effectiveness as a healthcare tool, VR technology is not well-integrated into common practice. This qualitative study aims to explore the provider perception of the value of VR and identify barriers to VR implementation among healthcare providers.

Methods: A 66-item self-report survey was created to examine application of VR to clinical practice, perceived …

Multifunctionality Of Prostatic Acid Phosphatase In Prostate Cancer Pathogenesis, Evgenia Alpert, Armin Akhavan, Arie Gruzman, William J. Hansen, Joshua Lehrer-Graiwer, Steven C. Hall, Eric Johansen, Sean Mcallister, Mittul Gulati, Ming-Fong Lin, Vishwanath R Lingappa

Journal Articles: Biochemistry & Molecular Biology

The role of human prostatic acid phosphatase (PAcP, P15309|PPAP_HUMAN) in prostate cancer was investigated using a new proteomics tool termed signal sequence swapping (replacement of domains from the native cleaved amino terminal signal sequence of secretory/membrane proteins with corresponding regions of functionally distinct signal sequence subtypes). This manipulation preferentially redirects proteins to different pathways of biogenesis at the endoplasmic reticulum (ER), magnifying normally difficult to detect subsets of the protein of interest. For PAcP, this technique reveals three forms identical in amino acid sequence but profoundly different in physiological functions, subcellular location, and biochemical properties. These three forms of PAcP …

Mobile Response Teams And The Youth Emergency Behavioral Health System, Paige J. Alitz

USF Tampa Graduate Theses and Dissertations

Introduction: This dissertation includes three separate manuscripts that coalesce under the shared topic of mobile crisis response and the emergency behavioral health system. Method: The first manuscript includes a synthesis of the research on mobile crisis response from the 1960s to present day to assess whether mobile crisis services can improve mental health care access in the U.S. for youth and adults. The second manuscript includes bivariate and multivariate analyses of MRT participant data to characterize participants who receive an involuntary psychiatric evaluation versus those who do not, and to assess factors associated with involuntary psychiatric evaluation or referral to …

Muscle Selection And Dosing In A Phase 3, Pivotal Study Of Abobotulinumtoxina Injection In Upper Limb Muscles In Children With Cerebral Palsy, Joyce Oleszek, Ann Tilton, Jorge Carranza Del Rio, Nigar Dursun, Marcin Bonikowski, Edward Dabrowski, Simon Page, Benjamin Regnault, Catherine Thompson, Mauricio R. Delgado

School of Medicine Faculty Publications

Background: Guidelines recommend botulinum toxin-A in pediatric upper limb spasticity as part of routine practice. Appropriate dosing is a prerequisite for treatment success and it is important that injectors have an understanding on how to tailor dosing within a safe and effective range. We report upper limb dosing data from a phase 3 study of abobotulinumtoxinA injections in children with cerebral palsy. Methods: This was a double-blind, repeat-treatment study (NCT02106351). In Cycle 1, children were randomized to abobotulinumtoxinA at 2 U/kg control dose or clinically relevant 8 U/kg or 16 U/kg doses. Doses were divided between the primary target muscle …

Digital Technology And Disease Surveillance In The Covid-19 Pandemic: A Scoping Review Protocol, Lorie Donelle Phd, Rn, Fcan, Jodi Hall, Brad Hiebert, Jacob J. Shelley, Maxwell J. Smith, Jason Gilliland, Saverio Stranges, Anita Kothari, Jacquelyn Burkell, Tommy Cooke, Jed Long, James M. Shelley, Deanna Befus, Leigha Comer, Marionette Ngole, Meagan Stanley

Publications

INTRODUCTION: Infectious diseases pose a risk to public health, requiring efficient strategies for disease prevention. Digital health surveillance technologies provide new opportunities to enhance disease prevention, detection, tracking, reporting and analysis. However, in addition to concerns regarding the effectiveness of these technologies in meeting public health goals, there are also concerns regarding the ethics, legality, safety and sustainability of digital surveillance technologies. This scoping review examines the literature on digital surveillance for public health purposes during the COVID-19 pandemic to identify health-related applications of digital surveillance technologies, and to highlight discussions of the implications of these technologies. METHODS AND ANALYSIS: …

Dietary Strawberries Improve Biomarkers Of Antioxidant Status And Endothelial Function In Adults With Cardiometabolic Risks In A Randomized Controlled Crossover Trial, Arpita Basu, Kenneth Izuora, Nancy M. Betts, Jeffrey L. Ebersole, Robert Hal Scofield

Kinesiology and Nutrition Sciences Faculty Research

Strawberries, a popularly consumed berry fruit, are rich in bioactive compounds with antioxidant effects. In this study, we examined the effects of two dietary achievable doses of strawberries on the antioxidant status and biomarkers of endothelial function in adults with features of metabolic syndrome and a confirmed low baseline of fruit and vegetable intake. In a 14-week randomized controlled crossover study, participants were assigned to one of three groups for four weeks separated by a one-week washout period: control powder, one serving (low dose: 13 g strawberry powder/day), or 2.5 servings (high dose: 32 g strawberry powder/day). Blood samples and …

Physical Activity, Exercise Training And Heart Failure: Does Intensity Matter?, Elizabeth A. Moxley

Faculty Articles, Papers, and Other Scholarship

Heart failure currently affects an estimated 6.2 million US adults¹ and approximately 2% of individuals on a global scale.² According to heart failure exercise guidelines by the American College of Cardiology Foundation and the American Heart Association (AHA), exercise training is considered an effective treatment for chronic heart failure at a class 1 level³ and recognized as a therapeutic approach for stable heart failure. Physical activity and exercise reduce symptoms, improve the quality of life and left ventricle function, lower heart rate response to submaximal exercise, and reverse remodeling in heart failure patients.^4-6

Ptsd As An Endothelial Disease: Insights From Covid-19, Adonis Sfera, Carolina Osorio, Leah Rahman, Carlos M. Zapata Martín Del Campo, Jose Campo Maldonado, Nyla Jafri, Michael Cummings, Steve Maurer, Zisis Kozlakidis

School of Medicine Publications

SARS-CoV-2 virus, the etiologic agent of COVID-19, has affected almost every aspect of human life, precipitating stress-related pathology in vulnerable individuals. As the prevalence rate of posttraumatic stress disorder in pandemic survivors exceeds that of the general and special populations, the virus may predispose to this disorder by directly interfering with the stress-processing pathways. The SARS-CoV-2 interactome has identified several antigens that may disrupt the blood-brain-barrier by inducing premature senescence in many cell types, including the cerebral endothelial cells. This enables the stress molecules, including angiotensin II, endothelin-1 and plasminogen activator inhibitor 1, to aberrantly activate the amygdala, hippocampus, and …

Community Assessment Of Water Perceptions And Household Point-Of-Use Treatment Methods In Madagascar, Isabella Rose Silverman

USF Tampa Graduate Theses and Dissertations

One in four people around the world do not have access to safe drinking water, which means that two billion people globally lack access. In high-income countries, 0.02% of yearly deaths are attributed to unsafe water sources; however, an alarming 10.6% of deaths occur in Madagascar, for the same reason.

To achieve Sustainable Development Goal 6: Ensure access to water and sanitation for all, a collaboration between public health and engineering is critical. Within the public health sector, social marketing is commonly utilized to address a problem by using commercial marketing principles to change behavior for the good of society. …

Atypical Involvement Of Central Nervous System In Classic Hodgkin Lymphoma: A Case Report, Shanila Ahmed, Babar Irfan, Muhammad Raza, Ghulam Haider

Section of Haematology/Oncology

Background: Hodgkin lymphoma is a systemic disease that commonly involves the cervical, supraclavicular, and mediastinal lymph nodes. The involvement of central nervous system in Hodgkin lymphoma is extremely rare, and diagnosis is usually established using distinct morphological and immunohistochemical staining on the tissue biopsied. Extranodal presentation of HL is a rare occurrence. It has been evident that prognosis is encouraging in patients with disease that is limited to just central nervous system initially or as relapse, compared with involvement of multiple sites of relapse.
Case presentation: We herein report a case of a 35-year-old South-East Asian male with relapsed Hodgkin …

Contact And Sars-Cov-2 Infections Among College Football Athletes In The Southeastern Conference During The Covid-19 Pandemic, Benika C. Dixon, Rebecca S.B. Fischer, Hongwei Zhao, Catherine S. O'Neal, James R. Clugston, Shawn G. Gibbs

School of Medicine Faculty Publications

No abstract provided.

Colloidal Nanomaterial Surface Chemistry And Characterization Studied By Linear And Nonlinear Spectroscopy, Asela Sampath Dikkumbura

LSU Doctoral Dissertations

Recent studies have demonstrated the use of nanomaterials such as metallic nanoparticles, liposomes, and polymer microparticles for biomedical applications, encompassing the field of nanomedicine. For developing novel core-shell metallic nanoparticles with controlled surface morphology, the in situ growth dynamics of colloidal silver-gold core-shell (Ag@Au CS) nanoparticles (NPs) in water are monitored in a stepwise synthesis approach using time-dependent second harmonic generation (SHG) and extinction spectroscopy. Transmission electron microscopy images show that the CS NP surface morphology becomes more smooth and uniform as the reaction proceeds, corresponding to lower, stable SHG signals and narrower plasmonic spectra that are compared to finite-difference …

Covid-19 Disease And Viral Characteristics In A Long-Term Care Facility, Shauna Assadzandi, Emily Crocetti, Courtney S. Pilkerton, Amie M. Ashcraft, Carl D. Shrader

Marshall Journal of Medicine

Background

Due to the combination of age, comorbidities, and close living quarters, residents at long-term care facilities (LTCFs) are at particularly high risk of severe symptoms and death due to COVID-19.

Methods

This cross-sectional study examines the relationship between demographic characteristics, symptom severity, and length of viral shedding in 49 residents testing positive for SARS-CoV-2 at a LTCF in West Virginia (WV).

Results

Over half of the residents were asymptomatic, while nearly a quarter experienced severe symptoms. Women were more likely to be asymptomatic, and age was not associated with symptom severity. While no specific medical condition was associated with …

Dysfunctional Voiding: Does A Validated Urine Color Scale Correlate With Dysfunctional Voiding Severity Score?, Katharina Mitchell, Chad Crigger, Tyler Overholt, Tyler Trump, John Barnard, Osama Al-Omar, Hilary Morley

Marshall Journal of Medicine

Introduction

Dysfunctional voiding (DV), defined as abnormal coordination between the urinary sphincter and the detrusor muscle in a neurologically intact individual, affects approximately 40% of patients that populate pediatric urology clinics. Improper hydration affects the specific gravity and concentration of urinary irritants, resulting in symptoms similar to those seen in DV patients.

Methods

Herein, we administered a validated DV survey (the Dysfunctional Voiding Symptom Score [DVSS]) and a validated dehydration severity chart (the Urine Color Chart [UCC]) to toilet trained pediatric patients and compared DV patients to patients presenting with non-urologic concerns. Data was analyzed on an item-for-item basis and …

Utility And Yield Of Genetic Testing Leading To A Definitive Neuromuscular Or Neuropathic Diagnosis At A Rural Outpatient Neurology Clinic Affiliated With A University Health Center In West Virginia Over 4 Years., Holly Farkosh, Dominika Lozowska

Marshall Journal of Medicine

Introduction

Clinicians are increasingly relying on genetic testing to pinpoint definite diagnoses. A more general diagnosis of neuropathy or neuromuscular disease like myopathy can be narrowed down substantially using genetic testing. Because carrier status is of utmost importance in reproductive matters, pathogenic results can prognosticate the future course of the illness and help plan ahead for treatment and social supports. Given the expense of genetic testing, it is important to assess the cost-benefit ratio to determine whether it is worthwhile to collect genetic samples. The purpose of the study was to determine the likelihood of obtaining a conclusive confirmatory diagnosis …

A Rare Case Of Right Lower Lobe Intralobar Pulmonary Sequestration In An Adult, Andrew J. Weaver, Jenalee Corsello, Peter Chirico, Mark H. Cooper

Marshall Journal of Medicine

Pulmonary sequestration is a rare congenital abnormality which is often diagnosed in childhood. There are two types of sequestration which are differentiated by the presence, or lack of pleural lining dividing the aberrant lung tissue from functional lung. Data for the management of this pathology in adults remains scarce. Here we present a case of intralobar pulmonary sequestration in an adult. The management of this patient comprised of surgical treatment involving lobectomy and ligation of the feeding vessel. The patient had an uneventful recovery and final pathology revealed a chronic infection in the sequestration.

Alpha-Gal Allergy: A New Threat To Appalachia, Adam M. Franks Md, Makala Murphy Bs, Madison Griffis Md, Rebekah Franks Ba, Cwr, Colin M. Franks, Gary Petty Md

Marshall Journal of Medicine

Abstract

Alpha-gal allergy, or mammalian meat allergy, is described as the development of IgE antibodies to the oligosaccharide galactose-a-1,3-galactose following a bite from the tick species Amblyomma americanum (Lone Star tick) or Dermacentor variabillis (Wood tick). Dermatologic or gastrointestinal symptoms are usually delayed by four to six hours after exposure, making the diagnosis difficult. Due to the use of mammalian proteins in many common medications, surgical equipment and prosthesis, unexpected reactions can occur. In the United States, this pathology is predominately seen in the southeast, but has been associated with other tick species on every continent except Antarctica. As the …

How One Nyc Hospital Handled The Covid-19 Pandemic- The Chief Residents’ Perspective, Sunny Arora, Krystyna Bronchard, Michaela Murphy, Stephen J. Peterson

Marshall Journal of Medicine

No abstract provided.

An Initiative To Improve Cultural Competence Among Gyn/Ob Providers, Lynn R. Mcdonald, Joshua L. Schwarz, Stephen J. Martin, Susan Brown Will, Shari M. Lawson, Tanesha Stokes, Shannon C. Riley, Katie Reynolds, Betty Chou

Journal of Health Disparities Research and Practice

Healthcare cultural competence is defined as a process of delivering care by meeting the social, cultural, and linguistic needs of diverse populations, and should be optimized at all organizational levels to reduce racial disparities and poor patient outcomes. The American College of Obstetrics and Gynecology (ACOG) recognizes the importance of cultural competence and states that research should be conducted to identify and combat barriers that impede equitable care. In this prospective, pre- and post-intervention study design, we used the Healthcare Provider Cultural Competence Instrument (HPCCI) to measure five dimensions of cultural competence within the Department of Gynecology and Obstetrics in …

Sociodemographic Factors Associated With Attendance To Brighter Bites, A School-Based Food Co-Op Nutrition Intervention For Low-Income Families, Melinda R. Rushing, Ru-Jye Chuang, Christine Markham, Shreela V. Sharma

Journal of Health Disparities Research and Practice

Participants: The analytic sample included 6,796 participants from five of the six cities in which Brighter Bites was implemented (Houston, Austin, Dallas, Washington, D.C., and Southwest Florida).

Main Outcome Measures: Predictor variables included child’s grade, gender, race/ethnicity, parent employment, and government assistance utilization. Outcome variable was a binary measure of attendance: 1=attendance at or above the threshold or 0=attendance below the threshold, where the threshold was operationalized as attending 75% of the distributions.

Analysis: A multi-level logistic regression and bivariate analysis were completed to measure the association between attendance and predictor variables.

Results: Results show, compared to Hispanics, Whites were …

Understanding Disparities In Clinical Trials For Native Hawaiian Men, Gabriela A. Layi, Kevin Cassel, Maile Taualii, Jeffrey L. Berenberg, Erin O. Bantum

Journal of Health Disparities Research and Practice

Understanding low rates of participation by minority populations in clinical trials is critical for reducing and eliminating disparities. We examined beliefs and attitudes of Native Hawaiian men related to illness and cancer to better understand their rates of participation in clinical trials. We conducted face-to-face interviews with Native Hawaiian key informants throughout the State of Hawai‘i using quota sampling methods to obtain a range of perspectives about attitudes towards health care seeking to provide insight into low clinical trials participation. Interviews were audio-taped, transcribed, and independently coded by researchers. Thematic analysis guided the extraction of relevant data from the discussions. …

A Scoping Review Of Barriers And Facilitators To Pap Testing In Women With Disabilities And Serious Mental Illnesses: Thirty Years After The Americans With Disabilities Act, Michele S. Lee, Jillian R. Peart, Julie S. Armin, Heather J. Williamson

Journal of Health Disparities Research and Practice

Background: Thirty years after the Americans with Disabilities Act (ADA) was passed, promising equal access to health services for people with disabilities and serious mental illness, research on Pap testing continues to uncover health disparities among women with disabilities and women with serious mental illnesses, including those that identify as an ethnic/racial minority.

Aim: The purpose of this paper is to describe and present the literature on the barriers and facilitators women with disabilities and women with serious mental illnesses face with receiving a Pap test using the social ecological model. We also examined the degree to which …

Untargeted Lipidomics Of Non-Small Cell Lung Carcinoma Demonstrates Differentially Abundant Lipid Classes In Cancer Vs. Non-Cancer Tissue, Joshua M. Mitchell, Robert M. Flight, Hunter N. B. Moseley

Molecular and Cellular Biochemistry Faculty Publications

Lung cancer remains the leading cause of cancer death worldwide and non-small cell lung carcinoma (NSCLC) represents 85% of newly diagnosed lung cancers. In this study, we utilized our untargeted assignment tool Small Molecule Isotope Resolved Formula Enumerator (SMIRFE) and ultra-high-resolution Fourier transform mass spectrometry to examine lipid profile differences between paired cancerous and non-cancerous lung tissue samples from 86 patients with suspected stage I or IIA primary NSCLC. Correlation and co-occurrence analysis revealed significant lipid profile differences between cancer and non-cancer samples. Further analysis of machine-learned lipid categories for the differentially abundant molecular formulas identified a high abundance sterol, …

Process Evaluation Of The Early Implementation Stages Of Thenational Diabetes Prevention Program Through Kentucky Cooperative Extension: Perceptions Of Adopters And Potential Adopters, Nicole Breazeale, Heather Norman-Burgdolf, Katherine Counts, Lovoria B. Williams

Journal of Human Sciences and Extension

With the growing demand for lifestyle change programs that prevent or delay Type 2 diabetes onset, community organizations with broad reach should be explored for national dissemination of the National Diabetes Prevention Program (NDPP). This study evaluates the early implementation of the NDPP through Cooperative Extension in four Kentucky counties and explores the feasibility of scaling up the program to additional counties. Using a qualitative approach, semi-structured telephone interviews were conducted with 12 Family and Consumer Sciences (FCS) Agents – four who were participating in the pilot (adopters) and eight who had no experience with the NDPP (potential adopters). Five …

Innovative Approach To Measure Effectiveness Of Handwashing Education In School-Age Children By Extension Educators, Katie Hoffman, Surine Greenway, Julie Buck, Grace Wittman, Jang Ho Kim

Journal of Human Sciences and Extension

University of Idaho Extension educators developed an innovative approach to analyze the effectiveness of handwashing lessons taught to school-age children. A protocol was designed to determine if there was a significant decrease in bacterial Colony Forming Units (CFUs) before and after implementing an educational handwashing lesson. The protocol allowed Extension educators with limited to no research experience to validate their handwashing lessons with scientific research. A 79% reduction in Mean CFU counts pre- and post-handwashing was found, excluding an outlier. The results support the effectiveness of Extension handwashing lessons using a novel quantitative approach

Pilot Development Of A Critical Food Safety Message Visual Communication Tool For Farmers’ Market Vendors, Lilly W. Jan, Shannon M. Coleman, Anirudh Naig

Journal of Human Sciences and Extension

Farmers’ markets are popular sources of fresh and ready-to-eat foods for consumers in the United States. However, research indicates that food safety practices of vendors and their employees serve as a concern for customers. This pilot study focused on assessing a visual-based, minimal-text educational tool that was disseminated to farmers’ market vendors and employees (n = 27) in Iowa. The tool was evaluated using a post-intervention survey of vendors’ and employees’ knowledge of food safety practices and their attitudes towards the educational tool. The results did not show a statistically significant increase in attitude and knowledge scores of farmers’ market …

Full Issue, Volume 9, Number 3, Donna J. Peterson, Scott Cummings

Journal of Human Sciences and Extension

No abstract provided.

The Mechanism And Pattern Of Injuries Of Undocumented Immigrants Crossing The Texas-Mexico Border Along The Rio Grande Valley, Carlos H. Palacio, Bianca Cruz, Cheryl Vanier, Jose Cano, Bradford G. Scott

School of Medicine Publications

Background

Apprehensions of undocumented immigrants in the Rio Grande Valley sector of the U.S.-Mexico border have grown to account for nearly half of all apprehensions at the border. The purpose of this study is to report the prevalence, mechanism, and pattern of traumatic injuries sustained by undocumented immigrants who crossed the U.S.-Mexico border at the Rio Grande Valley sector over a span of 5 years and were treated at a local American College of Surgeons verified Level II trauma center.

Methods

A retrospective chart review was conducted from January 2014 to December 2019. Demographics, comorbidities, injury severity score (ISS), mechanism …

Weakened Igg4 Staining And Positive Pla2r Staining Indicate Resolving Primary Membranous Glomerulopathy (Mgn), Y Al-Othman, W Li, H Kanaan, P Zhang

Conference Presentation Abstracts

Introduction/Objective: IgG4 related disease, a systemic autoimmune inflammatory disorders, can be identified by high% of IgG4 positive plasma cells, thus IgG4 staining in paraffin embedded tissue is widely available in the most of pathology labs. IgG4 staining has been found useful to identify primary MGN (PLA2R and/or THSD7A positive) by others and us. This study was to scrutinize the findings of primary vs secondary MGN needed for IgG4 staining as a screening tool in our renal pathology practice over pasts 5 years Methods/Case Report: IgG4 staining in paraffin embedded tissue was performed in 45 primary MGN and 43 secondary MGN …