Medicine and Health Sciences Commons^™

Delayed-Onset Anaphylactic Reaction With High Fever After Amoxicillin Oral Challenge And Negative Penicillin Skin Testing, Jordan Pitt, Paul J. Dowling, Christopher Miller, Aarti Pandya

Posters

Introduction:  Immunologic adverse drug reactions can be categorized based on Gell and Coombs’s classification system. Anaphylaxis is generally considered a type I, immediate, IgE-mediated reaction and typically occurs independent of other immunologic reactions. However, the child presented here reacted after amoxicillin challenge with features of type I and type III or IV hypersensitivity reactions. Case Description:  A 12-year-old female presented for amoxicillin allergy evaluation after treatment for scarlet fever with amoxicillin. After the second dose she developed rash with varied features, fatigue, edema, and joint swelling. Labs included a persistently low C4 level, eosinophilia, normal inflammatory markers, and normal tryptase …

Research News, Publications, 2021, Volume 3, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of July 30 through September 30, 2021

Accounting And Finance Lessons In The Time Of Covid-19: Views From The Pacific Basin: Part 2, Kuan Yong David Ding, Julie Harrison, Martien Lubberink, Chris Van Staden

Research Collection Lee Kong Chian School Of Business

The global COVID-19 pandemic is now in its second year, and we are fast approaching the third. The year 2021 has brought some hope that vaccination will lead to the end of the pandemic. But it has also brought a more infectious variant of COVID-19 and multiple waves of surging cases that show no immediate sign of disappearing. As the pandemic continues to impact global societies and economies, it is imperative that we study its impact to try and understand how it will affect us in both the short-term and long-term. While the longer-term impacts are still unknown, there is …

Health Inequality Analysis In Europe: Exploring The Potential Of The Eq-5d As Outcome, Inge Spronk, Juanita A. Haagsma, Erica I. Lubetkin, Suzanne Polinder, M F. Janssen, G J. Bonsel

Publications and Research

Objective: This study explored the additive value of the multi-item EuroQol 5-Dimension 5-Level (EQ-5D-5L) as an outcome measure in health inequality analyses, relative to the single-item EuroQol visual analog scale (EQ VAS).

Methods: A sample comprising the general population from Italy, the Netherlands, and United Kingdom (UK) completed the EQ-5D-5L and the EQ VAS. The level of education was selected as a proxy for socio-economic status (SES). EQ-5D-5L level sum scores (LSS) were compared against EQ VAS scores. Stratified and multivariable analyses were used to study the associations between SES and the LSS/EQ VAS relative to the presence of chronic …

Measuring The Effects Of Social Isolation And Dissatisfaction On Depressive Symptoms During The Covid-19 Pandemic: The Moderating Role Of Sleep And Physical Activity, Ivan Vargas, Erin Kaye Howie, Alexandria Muench, Michael L. Perlis

Psychological Science Faculty Publications and Presentations

Social distancing was universally implemented to reduce the spread of the COVID-19 virus. Long-term social distancing can lead to increased feelings of social isolation or dissatisfaction with one's daily interpersonal interactions, which can subsequently result in reduced psychological health (e.g., greater depression). The present study quantified this association, and the extent to which it was moderated by measures of sleep and physical activity, by surveying 3658 adults (mean age = 46.0 years) from across the United States. Participants answered questions related to their social experiences, sleep, physical activity, and depressive symptoms during the early stages of the pandemic (March-June 2020). …

Vol 2 November '21 Cover, Publishing And Table Of Contents, Donna L. Williams

Journal of the Louisiana Public Health Association

No abstract provided.

A Seat At The Table: Interprofessional Education And Public Health, Kari Brisolara

Journal of the Louisiana Public Health Association

No abstract provided.

Students: Publish In The Jlpha, Edward Trapido

Journal of the Louisiana Public Health Association

No abstract provided.

Student Commentary: Exploring The Role Of White Supremacy In The Pursuit Of Health Equity, Kori Lannaman, Amber Brown

Journal of the Louisiana Public Health Association

No abstract provided.

Vol 2 November '21 Full Issue, Donna L. Williams

Journal of the Louisiana Public Health Association

No abstract provided.

Program Evaluation - The "Consider Breastfeeding" Mixed Media Campaign For Breastfeeding Promotion" An Evaluation Of A Pilot Study, Caitrin Alb, Melissa Goldin Evans, Meshawn Tarver, Renata A. Granger, Elizabeth Langlois, Katherine Theall

Journal of the Louisiana Public Health Association

No abstract provided.

Criminal Conviction History And Psychiatric Symptom Severity In An Outpatient Trauma Clinic, Kayling J. Beiter, Elizabeth Whitham, Adina Suss, Erika Rajo, Erich J. Conrad

Journal of the Louisiana Public Health Association

Background: Physically traumatic injuries (PTIs) occur frequently among individuals with past criminal convictions, and PTIs often result in posttraumatic stress disorder (PTSD) and depression; non-treatment increases risk of crime and PTI recidivism. The objective of this study was to assess rates of PTSD and depression symptom severity before and after 6 sessions of engagement with an evidence-based outpatient trauma recovery program among cohorts with and without conviction history. Methods: Individuals who were treated for a PTI at a Level 1 Trauma Center were offered connection to the hospital’s associated outpatient trauma recovery program targeting PTSD, depression, and other mental health …

Community-Informed Perspectives On Barriers To Accessing New Orleans' Community-Based Clinics, Nikki Khorsandi

Journal of the Louisiana Public Health Association

Background: Low income, under- and uninsured patients in New Orleans can access health services through community-based clinics. Ensuring access to these services is critical in reducing health disparities and requires community members’ perspectives on existing barriers and how they can be removed. Methods: An eight-member community advisory council (CAC) met monthly to share perceived barriers to accessing care and generate solutions for individual clinics, the system of clinics, or statewide policy. Results: Eighteen barriers were identified by councilmembers, five of which were specifically discussed throughout CAC tenure. Councilmembers identified that a root cause of these barriers stemmed from a lack …

Incarceration Of A Household Member During Childhood And Health-Related Quality Of Life, Amy Hilliker, Andrei Stefanescu

Journal of the Louisiana Public Health Association

No abstract provided.

The Impacts Of Police Raids On Female Strippers In New Orleans, Alexandra Jaoiche, Allie Beth, Jeni Stolow, Gretchen Clum

Journal of the Louisiana Public Health Association

No abstract provided.

Implicit Bias And Racial Disparities In School Discipline Responses In Louisiana, Casey L. Thomas, Kaylin Beiter, Ashley Fenton, Stephen Phillippi

Journal of the Louisiana Public Health Association

Background: In Louisiana schools, there is high incidence and racially disparate use of suspension and expulsion. This analysis assessed parish-level associations between racial disparities in school discipline and implicit racial biases. Methods: Investigators examined disparities in the proportion of Black students experiencing a school discipline outcome relative to White peers from all parishes (N=64) over four years. Implicit bias measures were derived from scores on the Implicit Association Test (IAT), which estimates a participant’s implicit associations between race categories and positive or negative feelings. IAT test date was used to stratify results by school year. The analysis included 10,652 IAT …

Bisindolylmaleimide Ix: A Novel Anti-Sars-Cov2 Agent Targeting Viral Main Protease 3clpro Demonstrated By Virtual Screening Pipeline And In-Vitro Validation Assays, Yash Gupta, Dawid Maciorowski, Samantha E. Zak, Krysten A. Jones, Rahul S. Kathayat, Saara-Anne Azizi, Raman Mathur, Catherine M. Pearce, David J. Ilc, Hamza Husein, Andrew S. Herbert, Ajay Bharti, Brijesh Rathi, Ravi Durvasula, Daniel P. Becker, Bryan C. Dickinson, John M. Dye, Prakasha Kempaiah

Chemistry: Faculty Publications and Other Works

SARS-CoV-2, the virus that causes COVID-19 consists of several enzymes with essential functions within its proteome. Here, we focused on repurposing approved and investigational drugs/compounds. We targeted seven proteins with enzymatic activities known to be essential at different stages of the viral cycle including PLpro, 3CLpro, RdRP, Helicase, ExoN, NendoU, and 2′-O-MT. For virtual screening, energy minimization of a crystal structure of the modeled protein was carried out using the Protein Preparation Wizard (Schrodinger LLC 2020-1). Following active site selection based on data mining and COACH predictions, we performed a high-throughput virtual screen of drugs and investigational molecules (n = …

Down-Regulation Of Cyclin D2 In Amyloid Β Toxicity, Inflammation, And Alzheimer’S Disease, Joanna B. Strosznajder, Grzegorz A. Czapski, Magdalena Cieślik, Emilia Białopiotrowicz, Walter J. Lukiw

School of Medicine Faculty Publications

In the current study, we analyzed the effects of the systemic inflammatory response (SIR) and amyloid β (Aβ) peptide on the expression of genes encoding cyclins and cyclin-dependent kinase (Cdk) in: (i) PC12 cells overexpressing human beta amyloid precursor protein (βAPP), wild-type (APPwt-PC12), or carrying the Swedish mutantion (APPsw-PC12); (ii) the murine hippocampus during SIR; and (iii) Alzheimer’s disease (AD) brain. In APPwtPC12 expression of cyclin D2 (cD2) was exclusively reduced, and in APPsw-PC12 cyclins cD2 and also cA1 were down-regulated, but cA2, cB1, cB2, and cE1 were up-regulated. In the SIR cD2, cB2, cE1 were found to be significantly …

Outcomes For Hand Burns Treated With Autologous Skin Cell Suspension In 20% Tbsa And Smaller Injuries, George Malcolm Taylor, Scott A. Barnett, Charles T. Tuggle, Jeff E. Carter, Herb A. Phelan

School of Medicine Faculty Publications

In order to address the confounder of TBSA on burn outcomes, we sought to analyze our experience with the use of autologous skin cell suspensions (ASCS) in a cohort of subjects with hand burns whose TBSA totaled 20% or less. We hypothesized that the use of ASCS in conjunction with 2:1 meshed autograft for the treatment of hand burn injuries would provide comparable outcomes to hand burns treated with sheet or minimally meshed autograft alone. A retrospective review was conducted for all deep partial and full-Thickness hand burns treated with split-Thickness autograft (STAG) at our urban verified burn center between …

Navigating The Pandemic As It Enters Its Second Year, Havovi Joshi

Asian Management Insights

Many countries, enabled by the rapid vaccine rollout, experienced some moments of relief from the Covid-19 pandemic as they embarked on their long and winding transition toward normalcy. However, despite the Herculean effort expended, achieving herd immunity remains a distant goal for many due to the emergence of the highly transmissible and lethal Delta variant and the persistence of vaccine hesitancy. As such, the coronavirus continues to upend lives, businesses, and society, and the playbook for survival will still be a work-in-progress

Direct Oral Anticoagulants For Stroke Prevention In Patients With Atrial Fibrillation And Bioprosthetic Heart Valves, Vardhmaan Jain, Kirtipa Bhatia, Devika Aggarwal, Agam Bansal, Bharat Narasimhan, Michael J. Hendrickson, Sameer Arora, Michael J. Ricciardi, Arman Qamar

Articles

No abstract provided.

The Association Of Paid Medical And Caregiving Leave With The Economic Security And Wellbeing Of Service Sector Workers., Julia M. Goodman, Daniel Schneider

OHSU-PSU School of Public Health Faculty Publications and Presentations

Service-sector workers in the U.S. face extremely limited access to paid family and medical leave, but little research has examined the consequences for worker wellbeing. Our objective was to determine whether paid leave was associated with improved economic security and wellbeing for workers who needed leave for their own serious health condition or to care for a seriously ill loved one.

Ways Forward In Preventing Severe Maternal Morbidity And Maternal Health Inequities: Conceptual Frameworks, Definitions, And Data, From A Population Health Perspective, Suzan L. Carmichael, Barbara Abrams, Alison El Ayadi, Can Liu, Henry C. Lee, Deirdre J. Lyell, Audrey Lyndon, Elliott K. Main, Mahasin Mujahid, Lu Tian, Jonathan Snowden

OHSU-PSU School of Public Health Faculty Publications and Presentations

The objective of this commentary was to call attention to challenges to identifying population-level strategies for preventing SMM and its inequities, and to propose solutions. We focus on challenges to conducting research related to SMM within the U.S. context, although the points raised have broader global applicability. The challenges discussed include 1) the conceptual frameworks used to understand SMM, 2) defining SMM, and 3) the availability of data to assess SMM. By addressing these issues, we aim to advance research and efforts to improve health across the life course for people who give birth.

Kinematic Assessment Of Turning And Walking Tasks Among Stroke Survivors By Employing Wearable Sensors And Pressure Platform, Masoud Abdollahi, Pranav Madhav Kuber, Christopher Hoang, Michael Shiraishi, Rahul Soangra, Ehsan Rashedi

Physical Therapy Faculty Articles and Research

Stroke survivors often experience reduced movement capabilities due to alterations in their neuromusculoskeletal systems. Modern sensor technologies and motion analyses can facilitate the determination of these changes. Our work aims to assess the potential of using wearable motion sensors to analyze the movement of stroke survivors and identifying the affected functions. We recruited 10 participants (5 stroke survivors, 5 healthy individuals) and conducted a controlled laboratory evaluation for two of the most common daily activities: turning and walking. Among the extracted kinematic parameters, range of trunk and sacrum lateral bending in turning were significantly larger in stroke survivors (p-value<0.02). However, no statistical difference in mean angular velocity and range of motion for trunk/sacrum/shank flexion-extension were obtained in the turning task. Our results also indicated that during walking, while there was no difference in swing time, double support portion of gait among the stroke group was significantly larger (p-value = 0.001). Outcomes of this investigation may help in designing new rehabilitation programs for stroke and other neurological disorders and/or in improving the efficacy of such programs.Clinical Relevance— This study may provide a better insight on the detailed functional differences between stroke survivors and healthy individuals which in turn could be used to develop a more efficient rehabilitation program for stroke community.

The Scoop, Vol. 8 Issue 8, November 2021, Health Sciences Library

Volume 8

Latest news and updates from the Health Sciences Library in our monthly newsletter for November 2021.

Development, Preliminary Validation, And Reliability Of The Notetaking Abilities And Strategies Of University Students (Nasus) Questionnaire, Monique Chabot, Marie-Christine Potvin, Richard Hass, Abigail Garrity, Anne Bower

Department of Occupational Therapy Faculty Papers

With the increased use of technology in the classroom, notetaking methods have expanded. Current notetaking assessments for university students no longer reflect the options available or do not provide a comprehensive measurement of student preferences, skills, and perceptions of usefulness of notes. The Notetaking Abilities and Strategies of University Students (NASUS) questionnaire was created to address this gap in notetaking assessments while also examining university student preferences, perception of skills, desire to improve notetaking skills and methods of taking notes in class. The purpose of this study was to examine the psychometric properties of the NASUS questionnaire, specifically, content validity, …

Is Covid-19 Impacting Cancer Screening In Pakistan? An Observational Study Of Cancer Screening Test Requests During The Pandemic, Sibtain Ahmed, Muhammad Abbas Abid, Noureen Niaz Ali, Junaid Ahmed, Imran Siddiqui

Department of Pathology and Laboratory Medicine

Background: The purpose of this study is to assess how the COVID-19 pandemic affected cancer screening at a large tertiary care setting in the city of Karachi, the third largest city in the world, and to identify if there has been any decrease in cancer screening during the ongoing pandemic.
Methods: A retrospective observational study was conducted at the clinical chemistry laboratory at the Department of Pathology & Laboratory Medicine, Aga Khan University Hospital (AKUH), Karachi Pakistan. Data for test volumes was extracted from the Integrated Laboratory Management System (ILMS) for the following tumor markers: CA19 Carbohydrate Antigen 19-9 (CA …

Attenuated Bacteria Potentiate The Outcome Of Immunotherapy With Pd-L1 Blockade In A Pre-Clinical Model Of Colorectal Cancer, Besan Haytham Mohammad Al-Saafeen

Theses

After more than a century of investigation, it has become evident that cancer development and progression occur at the expense of a dysfunctional immune system. This realization has ushered cancer immunotherapy as a new modality of treatment. In the last decade, the use of immune checkpoint inhibitors to treat cancer patients resulted in unprecedented and durable clinical benefits. However, the response rate in many cancers remains rather modest, with colorectal cancer being at the lower end of the spectrum. Previous work from our laboratory demonstrated the efficacy of using attenuated bacteria as immunomodulatory anti-cancer agents. The current study investigated the …

Implementation Of A Transition Readiness Assessment And Transition Discussion Documentation In A Type 1 Diabetes Clinic, Sonalee Ravi

Presentations

Background/Objective: Our institution utilizes a general transition readiness assessment to facilitate transition discussions. Patients rate six areas of knowledge, eight skills, and confidence in ability to transfer care successfully prior to age 22, then select a goal for their next visit. Discussions are documented in the medical record. Our aim was to implement this assessment with a 20% documentation rate after six months.

Methods: In March 2021, we trained providers and diabetes educators about the need for transition planning, the differences between transition planning and transfer, and the need for documentation. We added three diabetes-specific questions related to insulin adjustments, …

Evaluation And Feasibility Of A Head Positioning Intervention In Patients With Intraparenchymal Hemorrhage, Wendy L. Dusenbury

Theses and Dissertations (ETD)

Stroke caused by intraparenchymal hemorrhage (IPH) is most commonly the result of hypertension-induced blood vessel rupture in the brain and is associated with devastating disability and high rates of death. To date, no intervention has improved outcomes in IPH stroke patients; however, head elevation may be one of the most important first steps to promote clinical stability in the hyperacute stage of IPH stroke because of the risk of increased intracranial pressure (ICP) in these patients. Nursing research completed in the late 1970s and early 1980s in patients with increased ICP due to traumatic brain injury showed that elevating the …