Medicine and Health Sciences Commons^™

Alternative Splicing Of Anxa7 Dictates Receptor Tyrosine Kinase Fates In Glioblastoma, Sindhu Nair

All ETDs from UAB

Alternative splicing (AS) is a tightly regulated process essential for lineage specification in complex tissues like the brain. Dysregulated splicing in glioblastoma (GBM) is a mechanism exploited by tumor cells to retain or splice out exons consequently rewiring isoform-specific protein interactions to sustain tumor phenotypes. Receptor tyrosine kinases (RTK) amplifications are frequent events in GBM driving tumor growth and progression and are key targets for chemotherapy. However, RTK targeting in GBM has achieved limited success predominantly due to adaptive mechanisms of resistance in a constantly evolving tumor microenvironment. Clonal populations and crosstalk between RTKs sustain heterogeneity within a tumor leading …

The Effects Of Implantoplasty On Implant Design Characteristics And Mechanical Strength, Peter Nasseh

All ETDs from UAB

Implantoplasty is defined as the mechanical removal of the implant threads and the macroscopically rough implant surface. Clinical outcomes such as probing depth and bleed-ing on probing measurements were shown to improve significantly after implantoplasty and peri-implant bone stability was achieved in the majority of the cases.This in-vitro study aims to investigate the effects of implantoplasty on the implant’s maximum compressing force and the type of failure that occurred on different implant sys-tems with different sizes, materials, collar designs and prosthetic connections. A total of 132 screw-shaped titanium implants from different manufacturers (Bi-oHorizons, Zimmer Biomet, and Nobel Biocare) and different …

Effectiveness Of Maxillary Molar Intrusion With The Invisalign System For Correction Of Anterior Open Bites, Logan Icenhour

All ETDs from UAB

Objective: The purpose of this study is twofold: To assess the amount of molar intrusion that can be predictably be achieved with clear aligners (Invisalign, Align Technology, Santa Clara, CA, USA) and to quantitatively document the dental and skeletal changes resulting from anterior open bite correction. Methods: This retrospective case-series study analyzed lateral cephalograms of 23 adult anterior open bite patients treated with Invisalign. Pre-treatment (IN) and post-treatment (FN) cephalograms were traced to determine changes as a result of treatment. 13 different variables were measured, 6 angular and 7 linear. All patients were treated consecutively by a single, experienced Invisalign …

Financial Performance Of Participating Hospitals In Accountable Care Organizations, Abdulrhman Alzhrani

All ETDs from UAB

The study examines the influence of accountable care organizations ACO participation on hospital financial performance. It poses two research questions: 1) how does ACO participation influence hospital financial performance? 2) How do organizational factors- hospital size, electronic health records (EHR) utilization, and ambulatory services- moderate the relationship between hospital ACO participation and financial performance? The study used longitudinal sample of general and surgical hospitals operating in United States from 2009 to 2017. The data were obtained from several sources including American Hospital Association (AHA), AHA survey of care system and payment, hospital cost reports, AHA information technology and Area Health …

An Airway Analysis Of Patients Diagnosed With Juvenile Idiopathic Arthritis Compared To A Control Group, Matt Gibson

All ETDs from UAB

Introduction: The temporomandibular joint (TMJ) is affected in 30-45%% of Juvenile Idiopathic Arthritis (JIA) patients, with all JIA subtypes at risk for TMJ involvement. JIA patients with TMJ involvement may present with altered craniofacial morphology, including micrognathia, mandibular retrognathia, a hyperdivergent mandibular plane angle, and skeletal anterior open bite. These features are also commonly present and associated with non-JIA pediatric patients with obstructive sleep apnea (OSA). Materials and Methods: The study comprised of a group of 32 JIA patients and a group of 32 healthy control subjects. CBCT images were taken for all patients and were imported into Dolphin Imaging …

Risk Of Coronary Heart Disease In Blood Of Marrow Transplant Survivors, Radhika Gangaraju

All ETDs from UAB

Background: Blood or marrow transplant (BMT) recipients are vulnerable to accelerated atherosclerosis due to prior exposure to chemotherapy and radiation, and consequent long-term cardiovascular morbidity, such as coronary heart disease (CHD). A comprehensive evaluation of the risk of late-occurring CHD in adult BMT survivors and the associated risk factors has not been performed. Patients and Methods: Using the Blood or Marrow Transplant Survivor Study (BMTSS), we analyzed the incidence and risk factors for CHD in patients who underwent BMT between 1974 and 2014, and survived ≥2 years. The risk of CHD was examined in BMT survivors as compared to 1,131 …

Maxillary And Mandibular Expansion Treatment With Invisalign First: A Retrospective Study Of Virtual Prediction Versus Clinical Outcomes, Laura Constanza Rey Londono

All ETDs from UAB

Introduction: The purpose of this retrospective study is to evaluate the maxillary and mandibular expansion achieved with Invisalign First (Align Technology, San Jose, CA) in growing children. Methods: Clinical stereolithography (STL) models of 32 patients in the mixed dentition stage, treated with the Invisalign First, were extracted from the ClinCheck software and analyzed in Dolphin imaging (version 11.95 Premium, Chatsworth, Calif) at three timepoints: T1 (initial records), T2 (virtual outcome prediction), and T3 (achieved outcome). The recorded measurements included: upper and lower primary intercanine and permanent intermolar width, upper and lower primary intercanine and permanent intermolar gingival width, upper arch …

An Analysis Of Preterm Birth Related To Sars-Cov-2 Infection By Race, Madeleine B. Mcgwin

All ETDs from UAB

Research investigating the association between pregnant women with COVID-19 infection and adverse birth outcomes, including preterm birth, having been contradicting. Individual differences between study populations, e.g., racial composition, may explain some of these inconsistencies. The aim of the present study is to determine if the association between SARS-CoV-2 infection and pre-term birth varies according to race. A cross-sectional study was conducted using data from the Vizient Clinical Data Base/Research Manager (CDB/RM). The study participants were women who gave birth in one of the Vizient facilities between March 2020 and January 2021. A positive COVID-19 test status was the primary exposure …

The Role Of Cd38 In Anti-Tumor Immunity And Tumor Immune Evasion, Panpan Yuan

All ETDs from UAB

CD38 is a multifunctional protein that is expressed in many immune cells, modulating NAD metabolism, inflammation and oxidative stress. Recent studies suggest that CD38 is also implicated in tumor immunosuppression. However, the role of CD38 in anti-tumor immunity and tumor immune evasion, and mechanisms involved, are still unclear. We hypothesized that CD38 expression by immune cells constricts T cell-mediated anti-tumor immune responses and promotes tumor cell immune evasion. We investigated whether mice lacking CD38 (CD38-/-) had impaired tumor growth in subcutaneous, intraperitoneal and intravenous syngeneic tumor models. CD38-/- mice showed no difference in subcutaneous B16 melanoma tumor growth and pulmonary …

Experience-Dependent Plasticitiy Of Functional Connectivity In Human Visual Cortex Following Central Vision Loss, Leland Lanelle Fleming

All ETDs from UAB

The human brain is shaped by a dynamic interplay between innate factors and life experiences. Neuroscience has long grappled with understanding this relationship, particularly with regard to how changes in experience impact the brain during adulthood. This question is especially important in the context of macular degeneration, a disease that causes significant visual impairment and drastically alters day-to-day visual experiences for individuals afflicted by the disease. Specifically, people with macular degeneration lose the ability to use vision in the center of the visual field, the region of the retina with the highest spatial resolution. Subsequently, these individuals must rely on …

The Impact Of Blimp1 On Etreg Stability And The Tumor Microenvironment, Michael Dixon

All ETDs from UAB

CD4+ Foxp3+ regulatory T (Treg) cells are responsible for maintaining immunological homeostasis and self-tolerance through the regulation of immune responses against foreign and self-antigens, and they comprise both central Treg and effector Treg (eTreg) subsets. Because of their ability to suppress potent immune responses, eTreg cells expressing the transcription factor Blimp1 are frequently recruited to the tumor microenvironment (TME) to suppress anti-tumor responses by tumor infiltrating effector cells. Here, we demonstrate in murine transplantable tumor models that Blimp1 is required for intratumoral eTreg stability and that loss of Blimp1 by intratumoral eTreg cells results in their reduced suppressive activity and …

Challenges For Nurse Anesthetists Re-Entering Practice Following Substance Use Disorder Treatment, T'Anya Marye Carter

All ETDs from UAB

Substance use disorder (SUD) is a persistent, relapsing condition that is present in approximately 10% of anesthesia providers, who, compared to other healthcare providers, face a greater risk of developing an SUD by virtue of constant access to medications. The ability of Certified Registered Nurse Anesthetists (CRNAs) to obtain employment or maintain employment after treatment for SUD treatment is not well documented. CRNAs in recovery from SUD in the United States experience challenges when attempting to return to work following treatment for SUD for reasons yet to be identified. The purpose of this qualitative multiple-case study was to explore the …

Assessment Of A Nutrition Education Program Designed To Enhance Mothers’ Attitudes On Infants And Young Children Feeding In Sudan, Ekhlas A.I. Mohammed, Zainab Taha, Agba A.A. Gadah-Eldam, Mariam M. El Hidai

All Works

AIM: The objective of the study was to assess the effect of a designed nutrition education program (NEP) on maternal attitudes. METHODS: A control two groups, quasi-experimental and pre-and post-experimental, were adopted. Data were collected through personal interviews of two groups using a validated questionnaire. The NEP was conducted in three phases. Phase 1 was the pre-evaluation, Phase 2 was the program’s implementation, and Phase 3 entailed post-evaluation of the program. RESULTS: The results supported the efficient role of the NEP intervention in raising mothers’ attitudes toward nutritional care of under 2 years in Sennar Locality, Sudan. There was no …

Nudging The N170 Forward With Prior Stimulation—Bridging The Gap Between N170 And Recognition Potential, Canhuang Luo, Wei Chen, Rufin Vanrullen, Ye Zhang, Carl Michael Gaspar

All Works

Evoked response potentials are often divided up into numerous components, each with their own body of literature. But is there less variety than we might suppose? In this study, we nudge one component into looking like another. Both the N170 and recognition potential (RP) are N1 components in response to familiar objects. However, the RP is often measured with a forward mask that ends at stimulus onset whereas the N170 is often measured with no masking at all. This study investigates how inter-stimulus interval (ISI) may delay and distort the N170 into an RP by manipulating the temporal gap (ISI) …

Performance In Mortality Prediction Of Saps 3 And Mpm-Iii Scores Among Adult Patients Admitted To The Icu Of A Private Tertiary Referral Hospital In Tanzania: A Retrospective Cohort Study, Nadeem Kassam, Eric Aghan, Samina Somji, Omar Aziz, James Orwa, Salim Surani

Internal Medicine, East Africa

Background: Illness predictive scoring systems are significant and meaningful adjuncts of patient management in the Intensive Care Unit (ICU). They assist in predicting patient outcomes, improve clinical decision making and provide insight into the effectiveness of care and management of patients while optimizing the use of hospital resources. We evaluated mortality predictive performance of Simplified Acute Physiology Score (SAPS 3) and Mortality Probability Models (MPM0-III) and compared their performance in predicting outcome as well as identifying disease pattern and factors associated with increased mortality.

Methods: This was a retrospective cohort study of adult patients admitted to the ICU of …

F-Wave Parameters And Body Mass Index In Carpal Tunnel Syndrome, Philip Adebayo, Rose E. Mwakabatika

Internal Medicine, East Africa

Background: Severe carpal tunnel syndrome (CTS) readily lends itself to both clinical and electrophysiological recognition. The uncertainty sometimes is in identifying and quantifying motor involvement in mild and, perhaps, in moderate CTS. Our study aimed to evaluate F responses in mild and moderate CTS and determine the contribution of BMI to the F-wave parameters.

Methods: A retrospective review of the clinical and electrophysiological data of patients with CTS seen at the clinical neurophysiology laboratory of Aga Khan Hospital, Dar es Salaam, between 1 August 2017 and 31 July 2019 was retrieved. Carpal tunnel syndrome was graded according to the …

Inspire : Vol 4, Issue 1, Department Of Medicine

INSPIRE – Department of Medicine Archives

Content

• Message From the Chair
• Medicine at National and International Forums
• In Depth- Section: featuring Dr Masooma Aqeel
• Featured Faculty: Dr Rumi Chunara “ … Sometimes ideas or their effects seem far off or unreachable, but it's really people like you and me, and small actions every day that are necessary to make change .
• What are Academics Around the World Reading This Month?
• Publications

Screening For Malnutrition In Oral Cavity Cancer Patients Prior To Treatment: A Cross-Sectional Study, Haissan Iftikhar, Anwar Suhail, Amna Urooba, Karim Rizwan Nathani, Zeeshan Shaikh, Muhammad Wasif

Section of Otolaryngology, Head & Neck Surgery

This study was conducted to assess the frequency of pre-operative malnourishment in patients being treated for oral cavity squamous cell carcinoma. A retrospective chart review was carried out at the Aga Khan University Hospital, Karachi, on 62 patients. Patients were screened pre-operatively through a standard nutritional assessment tool at the time of admission to assess for malnutrition. Mean age of presentation was 48.34±13.11 years, mean height was 165 ± 8.62cm, weight 66.09±14.98 kg and BMI of 24.09±4.84. Males were 82.3% and 17.7% were females. At the time of admission, a significant number or patients, 12 (19.4%) were prone to malnourishment, …

Training In Temporal Bone Surgery: A Review Of Current Practices, Muhammad Wasif, Abdul Basit Shah Vardag, Ainulakbar Mughal, Syed Akbar Abbas, Shayan Khalid, Hamdan Ahmed Pasha

Section of Otolaryngology, Head & Neck Surgery

The temporal bone consists of complex anatomy, and the presence of various vital structures in close proximity makes the surgery of temporal bone highly challenging. Such a surgery requires years of training under the direct observation of trainers. Over the course of history, different training models have been adopted by experts to help train the young surgeons in this complex procedure. Cadaveric dissections of the temporal bone remains the gold standard in training of residents as the cadavers present the actual anatomical details which the surgeons encounter while operating on patients. However, due to scarcity of available cadavers, their one-time-only …

Use Of Endoscope In Teaching Of Otolaryngology Residents About Site And Size Of Tympanic Membrane Perforation And Its Impact On Degree Of Hearing Loss In Adult Patients: A Cross Sectional Study, Muntazir Hussain, Muhammad Wasif, Mohammad Sohail Awan, Shayan Khalid, Zeeshan Sheikh, Haissan Iftikhar

Section of Otolaryngology, Head & Neck Surgery

Objective: To determine the association between site and size of perforation of the tympanic membrane and the level of conductive hearing.
Methods: The cross-sectional study was conducted from November 2015 to October 2016 at Aga Khan University Hospital Karachi and comprised patients with tympanic membrane perforation without any other middle-ear disease. Karl-Storz Rigid Endoscope attached to a camera was used to take pictures of the tympanic membrane. Site of the perforation was determined using a vertical line to divide the membrane into two anterior and posterior halves. Size of the perforation was calculated as a percentage of the total membrane …

How Inflammation, High-Density Lipoproteins, And Genes Affect The Relationship Between Apol1 And Kidney Outcomes, Ninad S. Chaudhary

All ETDs from UAB

Over the past decade, the discovery of novel genetic loci on chromosome 22q, apolipoprotein-L1 (APOL1), has given insights into the racial differences in kidney outcomes at the population level. APOL1 risk alleles are unique to African ancestry and confer increased susceptibility to end-stage kidney disease (ESKD) especially among individuals without diabetes. However, the diseases do not occur in all who inherit these alleles. Current efforts are driven towards identifying the factors that can interact with APOL1 in the development of kidney diseases. This dissertation investigated whether the association between APOL1 and kidney outcomes is affected by inflammatory markers (AIM1), high-density …

Structural Remodeling Of The Lumbar Multifidus, Thoracolumbar Fascia And Lateral Abdominal Wall Perimuscular Connective Tissues: Medium-Term Test-Retest Reliability Of Ultrasound Measures, Christian Larivière, Dany H. Gagnon, Richard Preuss

Études primaires

Abstract

Introduction

Growing interest is being paid to the lumbar multifidus (LM) intramuscular fatty infiltrations and fibrosis that are secondary to low back pain as well to the remodeling of perimuscular connective tissues (fasciae) such as the thoracolumbar fascia and fascia sheets separating the abdominalwall muscles. Magnetic resonanceimaging and computed tomography have traditionally been used but rehabilitative ultrasound imaging (RUSI) is much more affordable and practical, which can accelerate research and clinical applications on this topic. The aim of this study was to test the medium-term (8 weeks) test-retest reliability of the corresponding RUSI measures.

Methods

Thirty-four participants …

Clinical Supervisors' Experiences Addressing Age And Generational Cohort Affiliations With Counseling Supervisees, Susan N. Golden

Antioch University Dissertations & Theses

Diversity of cultural identities, such as abilities, age and generational cohort affiliation, and socioeconomic status and the practice of clinical supervision are rarely addressed in the professional counseling literature. Subsequently, there is a need for a greater understanding of how expanded cultural identities are addressed by clinical supervisors in the practice of clinical supervision. This research study focused specifically on how age and generational cohort affiliation are addressed as a cultural consideration by clinical supervisors during the practice of clinical supervision. For this study, the Interpretive Phenomenological Analysis research approach was utilized to answer the research questions: 1. How do …

The Editors’ Perspective: Online Teaching And Learning In A Pandemic, Cindy L. Hayden, Dana M. Howell, Renee Causey-Upton

Journal of Occupational Therapy Education

No abstract provided.

The Occupation-Centered Intervention Assessment: Bridging Theory And Practice In Fieldwork Education, Erin Main, Carolyn Michaud, Amelia Kellar, Kate Wondra, Vanessa D. Jewell, Taylor Wienkes, Brenda M. Coppard

Journal of Occupational Therapy Education

Occupational therapy’s identity is grounded in occupation-centered care. However, evidence suggests external factors in the healthcare system burden practitioners’ time and resources, reducing attention directed toward occupation-centered practice and student learning and transfer of theoretically grounded knowledge. The departure from theory-based practice can threaten the identity and viability of the profession. The Occupation-Centered Intervention Assessment (OCIA) was designed for practitioners or students to self-rate the degree to which interventions are occupation-based or occupation-focused, creating an occupation-centered framework. In this pilot explanatory sequential mixed methods study, Level II fieldwork educators and fieldwork students in Alaska completed OCIA training and utilized the …

Survey Of Occupational Therapy Education In Telehealth, Katrina M. Serwe, Ranelle Nissen

Journal of Occupational Therapy Education

Telehealth delivered occupational therapy services are increasing, and students will need to be prepared to safely and ethically deliver telehealth services. Occupational therapy education standards require that students demonstrate knowledge of telehealth and related technology. However, there is a limited discussion in the literature on how programs are preparing students to deliver services via telehealth. This explanatory mixed methods study examined telehealth education in entry-level occupational therapy programs to understand if and how students are learning about telehealth. The quantitative portion involved a survey of 429 occupational therapy programs in the United States. The qualitative part involved four survey respondents …

Meaning And Impact Of Interprofessional Simulation Participation For Occupational Therapy Students: A Qualitative Descriptive Study, Elena Wong Espiritu, Steven Busby

Journal of Occupational Therapy Education

Occupational therapy programs are incorporating simulation experiences more regularly into their curricula. However, there continues to be a need for more evidence demonstrating simulation benefits, particularly when various client populations, standardized actors, interpersonal skill practice, and multiple disciplines are incorporated into scenarios. The purpose of this qualitative descriptive study was to describe the meaning and impact of participating in an interprofessional simulation for occupational therapy students as part of their current academic preparation and future clinical practice in the hopes of increasing the participants’ interpersonal and clinical reasoning skills. Study participants were entry-level occupational therapy doctoral students (N=64) and their …

Application Of Active Learning Strategies For Online Delivery In An Occupational Therapy Assistant Program, Tiffany L. Benaroya, Jennifer C. George, Deborah Mckernan-Ace, Margaret Swarbrick

Journal of Occupational Therapy Education

The COVID-19 pandemic had a significant impact worldwide in every aspect of society including occupational therapy assistant students enrolled in academic coursework. This manuscript examines the unique experience of occupational therapy assistant faculty in a northeast state who were able to quickly modify classroom and lab teaching-learning strategies to a fully online virtual format for two semesters. Since no available information on strategies for online delivery of occupational therapy assistant education were found in the literature, their experiences implementing active learning strategies are described and discussed. Strategies covered include: the flipped classroom model; think-pair-share and jigsaw technique using breakout rooms; …

Perceptions Of Stress, Mindfulness, And Occupational Engagement Among Graduate-Level Occupational Therapy Students, Patricia Henton, Caroline Targonski, Acacia Gambrel, Catherine Rink, Sarah Wirtz

Journal of Occupational Therapy Education

Previous literature explored the concepts of stress, mindfulness, and occupational engagement, yet there is a substantial gap linking these terms within the field of occupational therapy (OT). The researchers identified a need to investigate the perceptions of these concepts among graduate-level OT students and its impact on their quality of life and occupational balance. Current research identified mindfulness and occupational engagement as healthy coping strategies for reducing stress and both concepts emphasized the action of being fully present and engaged. The exploratory mixed-methods study consisted of 490 students from graduate-level OT programs throughout the United States. Results revealed that the …

The Focuus Model— Facilitating Occupational Performance On Campus: Uplifting Underrepresented Students, Maribeth Clifton, Steven D. Taff

Journal of Occupational Therapy Education

The FOCUUS Model or Facilitating Occupational Performance on Campus: Uplifting Underrepresented Students, is a theoretically-based, evidence-centered model focused on ethnic minority (EM) students in higher education. The FOCUUS Model recognizes minority status as a determinant of health, where the experience of minority status stress (MSS) resulting from racism, stigmatization, marginalization, discrimination, microaggressions, and challenges to one’s sense of belonging largely influence one’s occupational performance, health, and overall well-being. Historical and contemporary injustices within American culture have resulted in multigenerational occurrences of disparities for EMs. Racial injustice is deeply embedded and still ever-present within practices and traditions in higher education institutions …