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2021

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Full-Text Articles in Medicine and Health Sciences

Feasibility And Acceptability Of A Technology-Based, Rural Weight Management Int Ervention In Older Adults With Obesity, John A. Batsis, Curtis L. Petersen, Matthew M. Clark, Summer B. Cook, David Kotz, Tyler L. Gooding, Meredith N. Roderka, Rima I. Al-Nimer, Dawna M. Pidgeon, Ann Haedrich, K. C. Wright, Christina Aquila, Todd A. Mackenzie Jan 2021

Feasibility And Acceptability Of A Technology-Based, Rural Weight Management Int Ervention In Older Adults With Obesity, John A. Batsis, Curtis L. Petersen, Matthew M. Clark, Summer B. Cook, David Kotz, Tyler L. Gooding, Meredith N. Roderka, Rima I. Al-Nimer, Dawna M. Pidgeon, Ann Haedrich, K. C. Wright, Christina Aquila, Todd A. Mackenzie

Dartmouth Scholarship

Background

Older adults with obesity residing in rural areas have reduced access to weight management programs. We determined the feasibility, acceptability and preliminary outcomes of an integrated technology-based health promotion intervention in rural-living, older adults using remote monitoring and synchronous video-based technology.

Methods

A 6-month, non-randomized, non-blinded, single-arm study was conducted from October 2018 to May 2020 at a community-based aging center of adults aged ≥65 years with a body mass index (BMI) ≥30 kg/m2. Weekly dietitian visits focusing on behavior therapy and caloric restriction and twice-weekly physical therapist-led group strength, flexibility and balance training classes were delivered using video-conferencing …


Effectively Communicating Comprehensive Tumor Genomic Profiling Results: Mitigating Uncertainty For Advanced Cancer Patients, Nicci Bartley, Megan C. Best, Barbara B. Biesecker, Alana Fisher, David Goldstein, Bettina Meiser, David M. Thomas, Mandy L. Ballinger, Phyllis Butow Jan 2021

Effectively Communicating Comprehensive Tumor Genomic Profiling Results: Mitigating Uncertainty For Advanced Cancer Patients, Nicci Bartley, Megan C. Best, Barbara B. Biesecker, Alana Fisher, David Goldstein, Bettina Meiser, David M. Thomas, Mandy L. Ballinger, Phyllis Butow

IES Papers and Journal Articles

Objective: To understand advanced cancer patients’ experience of uncertainty when receiving comprehensive tumor genomic profiling (CTGP) results, and their perceptions of how healthcare provider (HCP) communication impacts uncertainty.

Methods: Thirty-seven semi-structured interviews with advanced cancer patients were conducted within two weeks of patients receiving CTGP results. Transcripts were thematically analyzed, using an inductive approach.

Results: We identified three themes that illustrate patient experience of uncertainties when receiving CTGP results: 1. Type and degree of uncertainty fluctuates along with changing illness circumstances and the nature of the CTGP results; 2. HCPs’ co-ordination of care and communication shapes uncertainty, with immediate, clearer …


The Content, Teaching Methods And Effectiveness Of Spiritual Care Training For Healthcare Professionals: A Mixed-Methods Systematic Review, Kate Fiona Jones, Piret Paal, Xavier Symons, Megan C. Best Jan 2021

The Content, Teaching Methods And Effectiveness Of Spiritual Care Training For Healthcare Professionals: A Mixed-Methods Systematic Review, Kate Fiona Jones, Piret Paal, Xavier Symons, Megan C. Best

IES Papers and Journal Articles

Context: Spirituality has been demonstrated to play an important role in healthcare, yet many staff feel ill-equipped to deliver spiritual care. Spiritual care training programs have been developed to address this need.

Objective: The aim of this mixed-methods systematic review was to identify spiritual care training programs for healthcare professionals or students, and to investigate program content, teaching methods, key outcomes, and identified challenges and facilitators.

Methods: A mixed-methods systematic review was conducted. The search terms (‘religio*’ OR ‘spiritual*’ OR ‘existenti*’) were combined with (‘educat*’ OR ‘train*’ OR ‘curricul*’ OR ‘program*’), AND (‘care’ OR ‘therap*’ OR ‘treatment’ OR ‘competenc*’). Search …


Australian Perspectives On Spiritual Care Training In Healthcare: A Delphi Study, Kate F. Jones, Jennifer Washington, Matthew Kearney, David Kissane, Megan C. Best Jan 2021

Australian Perspectives On Spiritual Care Training In Healthcare: A Delphi Study, Kate F. Jones, Jennifer Washington, Matthew Kearney, David Kissane, Megan C. Best

IES Papers and Journal Articles

Objective: The aim was to establish core components of spiritual care training for healthcare professionals in Australia.

Methods: This study used the Delphi technique to undertake a consensus exercise with spiritual care experts in the field of healthcare. Participant opinion was sought on (i) the most important components of spiritual care training; (ii) preferred teaching methods; (iii) clinical scenarios to address in spiritual care training; and (iv) current spiritual assessment and referral procedures.

Results: Of the 107 participants who responded in the first round, 67 (62.6%) were female, 55 (51.4%) worked in pastoral care, and 84 (78.5%) selected Christian as …


Cancer Patient Knowledge About And Behavioral Intentions After Germline Genome Sequencing, Christine E. Napier, Grace Davies, Phyllis N. Butow, Timothy E. Schlub, Megan C. Best, Nicci Bartley, Ilona Juraskova, Bettina Meiser, Katherine M. Tucker, Barbara B. Biesecker, David M. Thomas, Mandy L. Ballinger, Members Of The Pigeon Project Jan 2021

Cancer Patient Knowledge About And Behavioral Intentions After Germline Genome Sequencing, Christine E. Napier, Grace Davies, Phyllis N. Butow, Timothy E. Schlub, Megan C. Best, Nicci Bartley, Ilona Juraskova, Bettina Meiser, Katherine M. Tucker, Barbara B. Biesecker, David M. Thomas, Mandy L. Ballinger, Members Of The Pigeon Project

IES Papers and Journal Articles

Objectives: Germline genome sequencing (GS) is becoming mainstream in cancer diagnosis and risk management. Identifying knowledge gaps and determinants of health behavior change intentions will enable effective targeting of educational and management strategies to translate genomic findings into improved cancer outcomes.

Methods: Probands diagnosed with cancer of likely genetic origin that consented to but not yet undergone GS, and their biological relatives, completed a cross-sectional questionnaire assessing GS knowledge and hypothetical intention to change behaviors.

Results: Probands (n = 348; 57% university educated) and relatives (n = 213; 38% university educated) had moderate GS knowledge levels, with greater knowledge associated …


Heeding The Call Of Covid-19, David Wiebers, Valery Feigin Jan 2021

Heeding The Call Of Covid-19, David Wiebers, Valery Feigin

Animal Sentience

We are grateful to all of our commentators. They have provided a wide range of valuable perspectives and insights from many fields, revealing a broad interest in the subject matter. Nearly all the commentaries have helped to affirm, refine, expand, amplify, deepen, interpret, elaborate, or apply the messages in the target article. Some have offered critiques and suggestions that help us address certain issues in greater detail, including several points concerning industrialized farming and the wildlife trade. Overall, there is great awareness and strong consensus among commentators that any solution for preventing future pandemics and other related health crises must …


Tacit To Explicit Knowledge Transfer In A University Health Care Program: Use Of Student-Professor And Professor-Professor Collaboration, Geela Spira, Allen S. Keener Jan 2021

Tacit To Explicit Knowledge Transfer In A University Health Care Program: Use Of Student-Professor And Professor-Professor Collaboration, Geela Spira, Allen S. Keener

Pedagogicon Conference Proceedings

Student feedback indicated difficulty applying Occupational Therapy values such as “participation in meaningful occupations” into clinical interventions. Two instructors of a components-based course and a theory course collaborated to link practical OT interventions to conceptual OT models. Use of a model for transfer of tacit knowledge was utilized. Each instructor kept a reflective diary. An iterative process for a semester attempted to transfer learned explicit knowledge into an integrated intuitive ‘art of the therapy’ which incorporated Occupational Science core concepts. Worksheets were developed to make the pathway more explicit. By semester’s end, students completed a comprehensive plan for client care.


Worker Health Inequities In Central America, Carlos Eduardo Siqueira Jan 2021

Worker Health Inequities In Central America, Carlos Eduardo Siqueira

Gastón Institute Publications

No abstract provided.


Analysis Of Covid 19 Mortality And Case Fatality In A Low Income Region Of Brazil, Carlos Eduardo Siqueira, Luiz C De Abreu Jan 2021

Analysis Of Covid 19 Mortality And Case Fatality In A Low Income Region Of Brazil, Carlos Eduardo Siqueira, Luiz C De Abreu

Gastón Institute Publications

Introduction: Inserted in the vulnerable context of the Brazilian Amazon, the state of Tocantins has suffered damages with the dissemination of COVID-19 in its territory; however, little evidence is published from this state. Objective: This study aims to analyze the case-fatality, mortality, and incidence of COVID-19 in Tocantins. Methods: This is an ecological study, population-based, time- series analysis of COVID-19 cases and deaths in the state of Tocantins from March 2020 to August 2021. Results: During the examined period, 219,031 COVID-19 cases, and 3,594 deaths were registered due to disease. Two possible occurrence peaks were characterized in this time- series …


A Time-Series Ecological Study Protocol To Analyze Trends Of Incidence, Mortality, Lethality Of Covid-19 In Brazil, Luiz C De Abreu, Khalifa Elmusharaf, Carlos Eduardo Siqueira Jan 2021

A Time-Series Ecological Study Protocol To Analyze Trends Of Incidence, Mortality, Lethality Of Covid-19 In Brazil, Luiz C De Abreu, Khalifa Elmusharaf, Carlos Eduardo Siqueira

Gastón Institute Publications

Introduction: since the first case of COVID-19 was confirmed in February 2020, Brazil has reported more than 20 million cases and more than 600,000 deaths on October 31, 2021. The behavior of the pandemic was also different in the various states, from the less developed to the more developed, such as the state of São Paulo. Objective: to describe step-by-step time series for analyzing trends in mortality, lethality and incidence of COVID-19 in Brazil. Methods: a protocol for an ecological study of time series, covering the 26 states and the federal district (Brasilia). Results: the descriptions have the potential to …


Networks Knowledge Brokers And The Public Policy, Rosalyn Negrón, Linda Sprague-Martinez, Carlos Eduardo Siqueira, Cristina Brinkerhoff Jan 2021

Networks Knowledge Brokers And The Public Policy, Rosalyn Negrón, Linda Sprague-Martinez, Carlos Eduardo Siqueira, Cristina Brinkerhoff

Gastón Institute Publications

This chapter presents a three-year, community-based health study of Boston Brazilian and Dominican transnational immigrants. A multi-level framework is used to understand the network factors that may impact how social, cultural, and health knowledge is shared between immigrants and immigrants and host society members. Results show that Brazilians in this study tended to have more heterogeneous networks, reported more close relationships with non-Brazilians, and more contact with non-Brazilians around health-seeking, as compared to Dominicans. Differences are discussed and framed in relation to macro-level structures, including racial hierarchies, transnationalism, and immigration laws. As such, we conclude with a discussion of how …


Mortalidad Por Diabetes En Guatemala 2018: Patrones E Inequidades, Alejandro Cerón, Gila Goldstein Jan 2021

Mortalidad Por Diabetes En Guatemala 2018: Patrones E Inequidades, Alejandro Cerón, Gila Goldstein

Anthropology: Faculty Scholarship

El presente estudio busca analizar la mortalidad por diabetes en Guatemala con el propósito de identificar posibles criterios epidemiológicos que orienten la priorización de acciones de salud pública. El riesgo de morir de diabetes en Guatemala muestra marcadas desigualdades por departamento, las que son aún más marcadas al comparar por municipio. El riesgo de morir es también más alto en mujeres, en personas mestizas o ladinas, en niveles educativos bajos, y en personas que se dedican a ocupaciones elementales. Deberían implementarse medidas de salud pública orientadas a los municipios y grupos en mayor riesgo de morir de diabetes. Este estudio …


Safety And Efficacy Of Balloon-Mounted Stent In The Treatment Of Symptomatic Intracranial Atherosclerotic Disease: A Multicenter Experience, Mahmoud H. Mohammaden, Raul G. Nogueira, Wondwossen G. Tekle, Santiago Ortega-Gutierrez, Mudassir Farooqui, Cynthia B. Zevallos, Ricardo Hanel, Gustavo M. Cortez, Amin Aghaebrahim, Ameer E. Hassan Jan 2021

Safety And Efficacy Of Balloon-Mounted Stent In The Treatment Of Symptomatic Intracranial Atherosclerotic Disease: A Multicenter Experience, Mahmoud H. Mohammaden, Raul G. Nogueira, Wondwossen G. Tekle, Santiago Ortega-Gutierrez, Mudassir Farooqui, Cynthia B. Zevallos, Ricardo Hanel, Gustavo M. Cortez, Amin Aghaebrahim, Ameer E. Hassan

School of Medicine Publications

Background Randomized clinical trials have failed to prove that the safety and efficacy of endovascular treatment for symptomatic intracranial atherosclerotic disease (ICAD) is better than that of medical management. A recent study using a self-expandable stent showed acceptable lower rates of periprocedural complications.

Objective To study the safety and efficacy of a balloon-mounted stent (BMS) in the treatment of symptomatic ICAD.

Methods Prospectively maintained databases from 15 neuroendovascular centers between 2010 and 2020 were reviewed. Patients were included if they had severe symptomatic intracranial stenosis in the target artery, medical management had failed, and they underwent intracranial stenting with BMS …


Educating Staff To Improve Colorectal Cancer Screening In A Primary Care Setting, Angela Kenyata Rayborn Jan 2021

Educating Staff To Improve Colorectal Cancer Screening In A Primary Care Setting, Angela Kenyata Rayborn

Walden Dissertations and Doctoral Studies

AbstractThe practice problem for this Doctor of Nursing Practice (DNP) project deals with the lack of education regarding colorectal cancer that is not being routinely screened by nursing staff within the primary care clinic setting. It is important that nursing staff is knowledgeable of current screenings for current health issues within their community in order to decrease prevalence and utilize preventive measures that can improve population health outcomes. Therefore, the purpose of this project was to conduct a staff education project to increase nursing knowledge about routine colorectal screenings. The model used for evaluation of this staff education project is …


Ambivalence Over Emotion Expression And The Effects Of Religious Coping In African American Christians, Anya Loraine Dobbs Jan 2021

Ambivalence Over Emotion Expression And The Effects Of Religious Coping In African American Christians, Anya Loraine Dobbs

Walden Dissertations and Doctoral Studies

African Americans are 10% more likely than non-Hispanic Whites to report having serious mental health issues from psychological stressors. Mental health concerns, such as depression and anxiety, that arise from psychological stressors, are more than likely to go untreated in African Americans. African Americans are more likely to turn to religion- their church, their pastors, and fellow parishioners to address these concerns. Religion and religious coping has influenced African Americans’ attitudes regarding help-seeking and mental health treatment, with the “Black Church” historically being a source of many things, including mental health care. Pargament’s theory of religious coping served as a …


Perceived Discrimination And Racism On The Treatment And Medication Adherence Of Hypertension In African Americans, Ifeoluwa Kayode, Daisy Tovar, Logan Cowan Jan 2021

Perceived Discrimination And Racism On The Treatment And Medication Adherence Of Hypertension In African Americans, Ifeoluwa Kayode, Daisy Tovar, Logan Cowan

Eagles Talking About the Public’s Health

No abstract provided.


Parental Substance Use And Its Impact On Children’S Health And Safety. Increased Need For Collaboration And Multidisciplinary Efforts, Blerta Shehaj, Joanne Chopak-Foss Jan 2021

Parental Substance Use And Its Impact On Children’S Health And Safety. Increased Need For Collaboration And Multidisciplinary Efforts, Blerta Shehaj, Joanne Chopak-Foss

Eagles Talking About the Public’s Health

No abstract provided.


Barriers To The Acquisition Of Quality Care For Intersex Populations, Katie M. Mercer, Destiny Jordan Jan 2021

Barriers To The Acquisition Of Quality Care For Intersex Populations, Katie M. Mercer, Destiny Jordan

Eagles Talking About the Public’s Health

No abstract provided.


Sauna Bathing: A Hidden Gem Of Health, Victoria Roy, Yelena Tarasenko Jan 2021

Sauna Bathing: A Hidden Gem Of Health, Victoria Roy, Yelena Tarasenko

Eagles Talking About the Public’s Health

No abstract provided.


Covid-19 Mitigation Strategies: A Case Study To Reduce The Spread And Promote Vaccine Uptake, Jill Johns, Joanne Chopak-Foss, Adekunle Adeyemi Jan 2021

Covid-19 Mitigation Strategies: A Case Study To Reduce The Spread And Promote Vaccine Uptake, Jill Johns, Joanne Chopak-Foss, Adekunle Adeyemi

Eagles Talking About the Public’s Health

No abstract provided.


Covid-19 And The Urgency For Advancements In Health Equity, Ifeoluwa Kayode, Gulzar H. Shah Jan 2021

Covid-19 And The Urgency For Advancements In Health Equity, Ifeoluwa Kayode, Gulzar H. Shah

Eagles Talking About the Public’s Health

No abstract provided.


“They Let Me Loose, Will You Hold Me Tight?” Adult Adoptees And Their Romantic Partners' Experience Of Attachment After Participating In The Hmt Program, Bethany Baker Jan 2021

“They Let Me Loose, Will You Hold Me Tight?” Adult Adoptees And Their Romantic Partners' Experience Of Attachment After Participating In The Hmt Program, Bethany Baker

Antioch University Dissertations & Theses

Adult adoptees may be blocked from feeling securely attached to their romantic partners and they may not even know it or what to do about it. The literature shows adult adoptees being overrepresented in insecure attachment styles, and not enough attention has been paid to the effect this has had on adoptees in their romantic relationships. In fact, no known study, to date, has provided an attachment-based psychoeducational approach for this marginalized population. The purpose of this introductory qualitative study was to explore the experiences and meaning-making of attachment, specifically related to adoption, for the adult adoptee and their romantic …


The Strategically Broken System: A Grounded Theory Study Of The Clinical Implications Of Immigration Law, Policy, And Practice, Kelle Agassiz Jan 2021

The Strategically Broken System: A Grounded Theory Study Of The Clinical Implications Of Immigration Law, Policy, And Practice, Kelle Agassiz

Antioch University Dissertations & Theses

The majority of clinicians do not receive education pertaining to the legal aspects of immigration in their curriculum, training, or continuing education. In addition, the process of navigating the immigration system has been exacerbated in recent years due to rapid policy changes under the Trump administration, which has contributed to a hostile political climate, particularly for immigrants from Central America and Mexico. Using a classic grounded theory research approach, this study explored the relationship between the psychological implications of immigration and the legal challenges that immigrants face today, with a specific focus on immigration from Central America and Mexico. Through …


I’M So Satisfied: A Qualitative Approach To Understanding The Process Of Marriage Satisfaction Among African American Couples, Rashida Spence Jan 2021

I’M So Satisfied: A Qualitative Approach To Understanding The Process Of Marriage Satisfaction Among African American Couples, Rashida Spence

Antioch University Dissertations & Theses

The current study uses a strengths-based framework to identify the process of marriage satisfaction among 1 same-sex African American married couple and 5 heterosexual African American married couples. Six themes emerged through qualitative analysis demonstrating that marriage satisfaction is a co-constructed experience created between couples through a series of interactions cultivating healthy conditions that strengthen relationship functioning and promote well-being. Based on the results the experience of marriage satisfaction is formed by the organizing concepts of connection, intentionality, purpose, sentiments of peace, authentic communication, and well-being. Results are discussed in association with existing research, as well as, Self-Determination, and Relationship …


A Rare Case Of Solid Pseudopapillary Neoplasm Of The Pancreas, Steven Michael, Nadeem Kassam, Aidan Njau, Omar A. Sherman, Harrison Chuwa, Salim Surani Jan 2021

A Rare Case Of Solid Pseudopapillary Neoplasm Of The Pancreas, Steven Michael, Nadeem Kassam, Aidan Njau, Omar A. Sherman, Harrison Chuwa, Salim Surani

General Surgery, East Africa

Solid pseudopapillary neoplasm of pancreas (SPN) is a rare entity. It is almost exclusively seen in females within the second and third decades of life with only small minority affecting children. Due to the paucity of the number of cases seen, the natural history of the disease is not fully understood. SPN tumors of the pancreas are usually found incidentally and usually have an excellent prognosis. We herein present a case of a 33-year-old lady diagnosed with SPN, who presented with abdominal fullness, two weeks post cesarean sectio


Understanding International Immobility Through Internal Migration: ‘Left Behind’ Nurses In The Philippines, Yasmin Y. Ortiga, Romeo Luis A. Macabasag Jan 2021

Understanding International Immobility Through Internal Migration: ‘Left Behind’ Nurses In The Philippines, Yasmin Y. Ortiga, Romeo Luis A. Macabasag

Research Collection School of Social Sciences

Migration scholars have tended to portray internal mobility as a step toward broader cross-border movement, reinforcing the notion of ongoing progress toward international migration. This article argues for a need to recognize how internal mobility can also explain international immobility, or why people do not move across national borders. Using the case of Filipino nurses, we argue that while internal migration does allow aspiring migrants to build the potential ability to emigrate, individual trajectories are much more diverse and multi-directional, often prolonging or reinforcing their international immobility. As a result, and in our case study, the costs and burdens of …


Physical Examination Findings In Patients With Protracted Concussion And The Impact Of An Integrative Concussion Rehabilitation Protocol, Lauren Ziaks, Chelsea Brown, Maura D. Iversen Jan 2021

Physical Examination Findings In Patients With Protracted Concussion And The Impact Of An Integrative Concussion Rehabilitation Protocol, Lauren Ziaks, Chelsea Brown, Maura D. Iversen

Physical Therapy Faculty Publications

Purpose: To describe physical examination (PE) findings of individuals with protracted concussion recovery and evaluate an integrated primitive reflex (PR) disinhibition, vision, and vestibular rehabilitation intervention. Method: Retrospective study of 82 patients with protracted concussion (60.98% female) who received ≥ 2 phases of treatment. Following a baseline PE, patients completed the Post-Concussion Symptom Survey (PCSS), Activities-Based Balance Confidence Questionnaire (ABC), Dizziness Handicap Index (DHI), and Acquired Traumatic Brain Injury (aTBI) Vision Questionnaire. A subset of patients (Group 1), completed a final PE and second questionnaire administration. Descriptive statistics characterized the sample. T-tests and Wilcoxon rank sum tests compared characteristics of …


Flop To Flip: Integrating Technology And Team-Based Learning To Improve Student Engagement, Diana Veneri, Elizabeth M. Mongillo Jan 2021

Flop To Flip: Integrating Technology And Team-Based Learning To Improve Student Engagement, Diana Veneri, Elizabeth M. Mongillo

Physical Therapy Faculty Publications

Purpose: The first attempt to develop and instruct a new course in evidence-based practice in a physical therapy curriculum proved problematic. The purpose of this paper is to describe the method of revising this traditionally taught course using a combination of flipping the classroom, team-based learning, and technology. Methods: Working with an Instructional Design Specialist, a weekly online preparatory module was created for each content topic using a variety of multimedia learning provisions including micro learning videos (PowerPoint with voiceover), transcript of the PowerPoint, a list of vocabulary words, reading, Quizlet, Flipgrids and Concept Checks. Each week’s module was introduced …


The Quality Of Intervention Reporting In Trials Of Therapeutic Exercise For Hip Osteoarthritis: A Secondary Analysis Of A Systematic Review, Louise C. Burgess, Thomas C. Wainwright, Khara A. James, Johan Von Heideken, Maura D. Iversen Jan 2021

The Quality Of Intervention Reporting In Trials Of Therapeutic Exercise For Hip Osteoarthritis: A Secondary Analysis Of A Systematic Review, Louise C. Burgess, Thomas C. Wainwright, Khara A. James, Johan Von Heideken, Maura D. Iversen

Physical Therapy Faculty Publications

Background: Therapeutic exercise is recommended as a core treatment for hip osteoarthritis (HOA). Whilst it is widely accepted that exercise can improve pain and disability, optimal type and dose of exercise are yet to be agreed upon. This may, in part, be attributed to the wide variation and inadequate reporting of interventions within the literature. This study evaluates the quality of intervention reporting among trials of therapeutic exercise in HOA.

Methods: Randomised controlled trials (RCTs) were sourced in a systematic review, completed in August 2020. Two raters independently used the Template for Intervention Description and Replication (TIDieR) and Consensus on …


Effect Of Pdgf-Bb On Human Retinal Pericytes, Matthew N. Parvus, Cristian Mercado, Francisco Elisarraras, Daniela Gonzalez, Andrew Tsin Jan 2021

Effect Of Pdgf-Bb On Human Retinal Pericytes, Matthew N. Parvus, Cristian Mercado, Francisco Elisarraras, Daniela Gonzalez, Andrew Tsin

School of Medicine Publications

Background – The majority of ocular conditions seen in patients with diabetic retinopathy are a result of damage to the retinal vasculature, which leads to microaneurysms, hemorrhage, and eventually neovascularization. The first step in the pathogenesis of these conditions is derived from the loss of Human Retinal Pericytes (HRPs), or cells which are essential to the preservation of the integrity of the retinal vasculature, and PDGF-BB is the primary promotor of growth and recruitment for HRPs.

Aim - Patients with NPDR produce lower levels of PDGF-BB than in normal conditions, which could contribute to the loss of pericytes early in …