Medicine and Health Sciences Commons^™

Comparison Of Frozen-Thawed Embryo Transfer Protocols In Patients With Previouscycle Cancellation Due To Uterine Peristalsis: A Pilot Study, İlknur Selvi̇, Mehmet Erdem, Erhan Demi̇rdağ, Müni̇re Funda Cevher Akdulum, Cengi̇z Karakaya, Ahmet Erdem

Turkish Journal of Medical Sciences

Background/aim: To investigate the optimal protocol for frozen-thawed embryo transfer (FET) cycles in patients who previously had a cycle cancellation due to uterine peristalsis (UP). Materials and methods: Thirty-four patients with previous embryo transfer (ET) cancellation due to UP during artificial cycle (AC) were included retrospectively. In the proceeding cycle, endometrium was prepared with AC (n: 23) in AC-FET group or with stimulated cycle that contains letrozole (L) (n: 11) in L-FET group. Intravenous bolus dose of 6.75 mg atosiban (Tractocile; Ferring Pharmaceuticals, Switzerland) injection was performed to all patients of AC-FET group due to UP ≥ 4/min on the …

An Investigation Of The Factors That Influence Functional Improvement In Strokerehabilitation, Onur Altuntaş, Serkan Taş, Alp Çeti̇n

Turkish Journal of Medical Sciences

Background/aim: The purpose of this study was to determine effect of age, sex, affected extremity, disability severity, treatment type, cerebrovascular accident (CVA) etiology, number of treatment sessions, and CVA duration on the functional improvement of the stroke patients who participated in a physical medicine and rehabilitation program. Materials and methods: The research sample consisted of 322 stroke patients. Clinical and demographic features including age, sex, affected extremity, disability severity, treatment type, CVA etiology, number of treatment sessions, and CVA duration were recorded. Functional status was evaluated retrospectively by using the functional independence measure (FIM) at admission and discharge. Results: It …

The Effect Of Ankaferd Blood Stopper On Liver Damage In Experimental Obstructivejaundice, Koray Koşmaz, Abdullah Durhan, Marlen Süleyman, Yilmaz Ünal, Mustafa Taner Bostanci, Tuğba Yi̇ği̇t Haskaraca, Can Ersak, Mehmet Şeneş, İlknur Alkan Kuşabbi̇, Eylem Pinar Eser, Sema Hücümenoğlu

Turkish Journal of Medical Sciences

Background/aims: To evaluate the potential protective effects of Ankaferd blood stopper (ABS) in an experimental obstructive jaundice (OJ) model. Materials and methods: The study included 26 female rats, which were divided into 3 groups. The sham group, consisting of 10 rats, (group 1) only received solely laparotomy. In the control group, consisting of 8 rats, (group 2), ligation was applied to the biliary tract and no treatment was implemented. In the treatment group, consisting of 8 rats, (group 3), following ligation of biliary tract, 0.5 mL/day ABS was given for 10 days. Liver tissue and blood samples were taken for …

Effects Of The Covid-19 Pandemic On Psychology And Disease Activity In Patients Withankylosing Spondylitis And Rheumatoid Arthritis, Şaki̇r Gica, Yasemi̇n Akkubak, Zaki̇re Kübra Aksoy, Adem Küçük, Erkan Cüre

Turkish Journal of Medical Sciences

Background/aim: The COVID-19 outbreak is known to increase stress levels of most patients with chronic diseases. Patients with ankylosing spondylitis (AS) and rheumatoid arthritis (RA) are highly susceptible to environmental stress. In the current study, we aimed to determine how the COVID-19 pandemic psychologically affected patients with chronic progressive diseases such as AS and RA and the effects of these psychological factors on disease activity. Materials and methods: Age and sex-matched patients with AS (n = 80), RA (n = 80), and healthy controls (n = 80) were included in the study. All participants were evaluated with the "Perceived COVID-19 …

Covid-19 Clinical Course And Blood Groups: Turkish Population-Based Study, Mehmet Si̇nan Dal, Nai̇m Ata, Fevzi̇ Altuntaş, Semi̇h Başci, Tuğçe Nur Yi̇ğenoğlu, Serdal Korkmaz, Si̇nem Namdaroğlu, Abdulkadi̇r Baştürk, Tuba Hacibeki̇roğlu, Mehmet Hi̇lmi̇ Doğu, İlhami̇ Berber, Kürşat Dal, Mehmet Ali̇ Erkurt, Burhan Turgut, Murat Çağlayan

Turkish Journal of Medical Sciences

Background/aim: SARS-CoV-2 enters the cell through the binding of the S glycoprotein on the surface of the virus to the angiotensinconverting enzyme 2 (ACE-2) in the host cells and also SARS-CoV S protein binding to ACE-2 was inhibited by anti-A antibodies. The aim of the study was to investigate the relationship between blood groups and the course of COVID-19 in Turkey. Materials and methods: Laboratory confirmed COVID-19 patients aged 18 and over (n = 39.850) were randomized in age and sexmatched groups according to blood groups Results: Advanced age, male sex and blood group A were found to be related …

Risk Factors Associated With Mortality In Intensive Care Covid-19 Patients: Theimportance Of Chest Ct Score And Intubation Timing As Risk Factors, Veci̇he Bayrak, Nurcan Şentürk Durukan, Ferhan Demi̇rer Aydemi̇r, Begüm Ergan, Naci̇ye Si̇nem Gezer, Oya Özlem Eren Kutsoylu, Ali̇ Necati̇ Gökmen, Yusuf Savran

Turkish Journal of Medical Sciences

Background/aim: Coronavirus disease 2019 (COVID-19) is a disease with a high rate of progression to critical illness. However, the predictors of mortality in critically ill patients admitted to the intensive care unit (ICU) are not yet well understood. In this study, we aimed to investigate the risk factors associated with ICU mortality in our hospital. Materials and methods: In this single-centered retrospective study, we enrolled 86 critically ill adult patients with COVID-19 admitted to ICU of Dokuz Eylül University Hospital (İzmir, Turkey) between 18 March 2020 and 31 October 2020. Data on demographic information, preexisting comorbidities, treatments, the laboratory findings …

Attention-Deficit Hyperactivity Disorder Symptoms And Quality Of Life In Female Patientswith Fibromyalgia, Gözde Türkoğlu, Yavuz Selvi̇

Turkish Journal of Medical Sciences

Background/aim: The present study aimed to determine the association between attention-deficit hyperactivity disorder (ADHD) symptoms severity, fibromyalgia (FM) severity, and QoL. Materials and methods: While the FM group consisted of 113 (74%) patients, the control group consisted of 40 (26%) individuals. FM symptom severity, ADHD symptom severity, and QoL were evaluated using the fibromyalgia impact questionnaire (FIQ), adult ADHD self-report scale (ASRS), and World Health Organization quality of life scale-brief version (WHOQOL-BREF), respectively. Results: It was found that the FM group had significantly higher scores on the ASRS than the control group (p < 0.05). There was a significant difference in FIQ scores and three WHOQOL-BREF domain scores between the FM alone and comorbid FM/high probability of ADHD groups (p < 0.05). We found a negative correlation between ASRS total scores and all other scale scores (except for the social relationships domain score of the WHOQOL-BREF) and a positive correlation between ASRS total scores and FIQ scores in FM patients. ADHD scores would mediate the relationship between depression severity and QoL. Conclusions: Our findings indicated that the presence of ADHD symptoms was related to greater FM symptom severity and poorer QoL. Also, ADHD scores would mediate the relationship between depression severity and QoL.

Utilization Of Biotechnological Drugs In Rare Diseases Requiring The Use Of Off-Label Drugsin Children In Turkey, Neri̇man İpek Kirmizi, Volkan Aydin, Nari̇n Akici, Banu Bayar, Ahmet Akici

Turkish Journal of Medical Sciences

Background/aim: Pediatric patients, especially those with rare diseases, represent a population that has a high tendency towards offlabel drug use (OLDU) and needs a more careful practice of pharmacotherapy than in adults. We aimed to investigate biotechnological drug use in children with rare diseases requiring OLDU. Materials and methods: This retrospective study examined all single-diagnosed OLDU applications (n = 5792) for 4992 children (

Can Patients Who Apply To Tertiary Care With Headache For The First Time Be Managed Inprimary Care? - A Cross-Sectional Study, Esra Hündür Doğan, İrfan Şencan, Hasan Doğan, Adem Özkara

Turkish Journal of Medical Sciences

Background/aim: Headaches are one of the most common neurological symptoms. They adversely affect daily life, reduces the workforce, and have high health costs. Managing this symptom in primary care will free up secondary and tertiary health services to better treat patients who need follow-up by specialists. In the present study, we aim to show the rate at which this problem can be solved in primary care for patients who applied tertiary care services with a headache for the first time. Materials and methods: Our research is a cross-sectional study of 207 patients who applied to the neurology clinics for the …

Increased Incidence Of Malignancy In Patients With Primary Hyperparathyroidism, Meli̇a Karaköse, Muhammet Kocabaş, Mustafa Can, Hati̇ce Çalişkan Burgucu, İlker Çordan, Mustafa Kulaksizoğlu, Feri̇dun Karakurt

Turkish Journal of Medical Sciences

Background/aim: Primary hyperparathyroidism (PHPT) is a disease that is diagnosed more frequently and generally in the asymptomatic period, with widely available biochemical tests. Evidence suggesting an association between PHPT and malignancy risk is increasing. Clarification of this association will be useful in PHPT for malignancy screening and management of patients with PHPT. In this study, we aimed to investigate the frequency of cancer in PHPT patients. Materials and methods: A total of 775 PHPT patients were included in the retrospective study. Demographic, clinical and laboratory data of the patients were evaluated retrospectively. Results: Malignancy was detected in 128 (16.50%) of …

Evaluation Of Proprioception In Patients Who Underwent Acl Reconstruction:Measurement In Functional Position, Si̇nem Suner Kekli̇k, Nevi̇n Aysel Güzel, Gamze Çobanoğlu, Ni̇han Kafa, Muhammet Baybars Ataoğlu, Zekeri̇ya Öztemür

Turkish Journal of Medical Sciences

Background/aim: Anterior cruciate ligament (ACL) injuries cause mechanoreceptor loss in the joint; therefore, proprioceptive deficits are observed after injury. In particular, proprioceptive measurements made in the functional position give more accurate results, and this is an area that requires further studies. This study aimed to evaluate proprioception in patients who had undergone ACL reconstruction (ACLR) in functional positions used in daily life (closed kinetic chain position), according to joint angles where ACL injuries occur more frequently, in comparison with healthy controls. Materials and methods: Thirty-four participants who underwent ACLR using a hamstring tendon graft (aged 29.18 ± 8.16 years; body …

Effects Of Intracerebroventricularly Administered Opioid Peptide Antagonistson Tissue Glycogen Levels In Rats After Exercise, Ayşe Şebnem İlhan, Şevi̇n Güney, Si̇bel Di̇ncer

Turkish Journal of Medical Sciences

Background/aim: Physical exercise is a state of physiological stress that requires adaptation of the organism to physical activity. Glycogen is an important and essential energy source for muscle contraction. Skeletal muscle and liver are two important glycogen stores, and the energy required to maintain exercise in rodents are provided by destruction of this glycogen depot. In this study, the effects of endogenous opioid peptide antagonism at the central nervous system level on tissue glycogen content after exhaustive exercise were investigated. Materials and methods: Rats had intracerebroventricularly (icv) received nonspecific opioid peptide receptor antagonist, naloxone (50 μ/10 μL in saline) and …

Role Of Frailty In Prediction Of Hospitalized Older Adult Patient's Outcomes: A Prospective Study, Maryam Chehrehgosha, Reza Fadaye Vatan, Mahtab Alizadeh Khoei, Farshad Sharifi, Reyhaneh Aminalroaya, Zahra Vahabi, Abolfazl Zendedel, Hamidreza Hekmat

Turkish Journal of Medical Sciences

Background/aim: Frailty is associated with an increased risk of negative short-term and long-term hospital outcomes. This study aimed to evaluate the role of frailty in predicting readmission, length of stay, and quality of life in the hospitalized older adults. Materials and methods: This observational study was conducted at Ziaiyan Hospital, Tehran, Iran. In total, 304 participants (65-85 years), were enrolled through the inclusion criteria from August to December 2019. The frailty index (FI) was assessed by the minimum data set-home care. Readmission was obtained through telephone interviews. The length of stay was gathered by the patient's hospital records, and the …

Evaluation Of Serum Neutrophil Gelatinase-Associated Lipocalin (Ngal), Asymmetricdimethylarginine (Adma) And Symmetric Dimethylarginine (Sdma) Levels, And Theirrelations With Disease Type And Activity In Inflammatory Bowel Diseases, Hüseyi̇n Korkmaz, Mehmet Asil, Tuncer Temel, Bahadir Öztürk, Levent Kebapcilar

Turkish Journal of Medical Sciences

Background/aim: Inflammatory bowel disease (IBD) mainly encompass two entities called ulcerative colitis (UC) and Crohn's disease (CD), both of which are chronic, progressive and, inflammatory conditions of the gastrointestinal tract. Various indicators and noninvasive markers have been sought and used in IBD patients to help assessing disease activity and treatment effectiveness although none of them are proven to yield definite results in full correlation with the clinical, endoscopic, and histopathological examinations. The aim of the current study was to investigate the relationship of serum neutrophil gelatinase-associated lipocalin (NGAL), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) levels with disease type and …

Factors Influencing The Length Of Stay In The Palliative Care Unit In Patients Dischargedhome: Results From A Tertiary Hospital In Turkey, Hi̇lal Zengi̇n, İlker Taşçi

Turkish Journal of Medical Sciences

Background/aim: Increased length of stay (LOS) in the palliative care unit (PCU) is a serious burden to the patients and the health care system. The predictors of longer LOS in a PCU have not been reported so far from Turkey. Our aim in this study was to evaluate the factors associated with the LOS in the PCU of a tertiary hospital. Materials and methods: This cross-sectional analysis of a retrospective cohort evaluated adult patients' medical records admitted to the PCU between 2017 and 2019. The main inclusion criteria were 4 or more days of palliative unit stay and being discharged …

What Plays A Role In The Severity Of Atopic Dermatitis In Children?, Murat Cansever, Çi̇ğdem Oruç

Turkish Journal of Medical Sciences

Background/aim: Determining the characteristics and risk factors of severe disease is extremely important to combat atopic dermatitis (AD), which has recently shown increasing prevalence. In this study, we aimed to investigate the clinical characteristics of pediatric patients with AD and identifying the factors associated with the severity of the disease. Materials and methods: A total of 304 pediatric patients diagnosed with atopic dermatitis were included in the study. The patients' age at admission, age at onset of symptoms, the presence of atopy history in their family, eosinophil levels obtained from blood counts were recorded, together with the data of cigarette …

The Contribution Of Neurocognitive Situation, Physical Capacity And Daily Life Activities Toquality Of Life In Childhood Acute Lymphoblastic Leukemia Survivors, Eli̇f Keleş Gülnerman, Yağmur Çam, Bülent Elbasan, Şebnem Soysal, Zühre Kaya, İdi̇l Yeni̇cesu, Ülker Koçak

Turkish Journal of Medical Sciences

Background/aim: There are no extensive studies on the QL in children who completed acute lymphoblastic leukemia (ALL) treatment and currently living without any disease in Turkey. Our study aimed to analyze both the QL and the effects of physical, neurocognitive capacities on QL in childhood ALL survivors aged 7-12 years at the time of recruitment. Materials and methods: PedsQL cancer module 3.0 child and proxy report, for ages 5-7 and 8-12 years, WeeFIM scale, BOTMP Short Form, RPM, reading, writing, and mathematics assessment tools, sociodemographic information form were carried out to the children and their family. Results: There was no …

Dual Energy Ct In Necrotizing Enterocolitis; A Novel Diagnostic Approach, Özgür Çağlar, Emrullah Cesur, Recep Sade, Bi̇nali̇ Firinci, Mustafa Kara, Mehmet Emi̇n Çeli̇kkaya, Akgün Oral, Murat Yi̇ği̇ter, Sevi̇lay Özmen

Turkish Journal of Medical Sciences

Background/aim: Necrotizing enterocolitis (NEC) is one of the most important causes of morbidity and mortality in premature infants. Although there are no specific diagnostic tools, the main factors affecting prognosis are clinical and laboratory findings, and early diagnosis and treatment. In this study, we demonstrate the importance of dual-energy computed tomography (DECT) in confirming intestinal ischemia in neonates with NEC. Materials and methods: Patients diagnosed with NEC in a neonatal intensive care unit were staged according to modified Bell's classification, and DECT was performed on patients with NEC stages 2-A, 2-B and 3-A. According to their DECT reports, these patients …

Effects Of Resistance Training On Muscle Quality Index, Muscle Strength, Functional Capacity, And Serum Immunoglobulin Levels Between Obese And Non-Obese Older Women, Paulo Roberto Silva Junior, Dahan Da Cunha Nascimento, Ivo Vieira De Sousa Neto, Silvana Schwerz Funghetto, Ramires Alsamir Tibana, James W. Navalta, Fabiani Lage Rodrigues Beal, Jonato Prestes

Kinesiology and Nutrition Sciences Faculty Research

International Journal of Exercise Science 14(7): 707-726, 2021. Considering the negative impact of obesity on neuromuscular and immune systems, we sought to compare the effects of a 10-week resistance training (RT) program on muscle quality index (MQI), muscle strength, functional capacity, and immunoglobulins in older women with and without obesity. Thirty-nine older women participated in the present study (age: 69.02 ± 6.16, fat (%): 38.80% ± 6.28) and underwent a linear RT program performed on two non-consecutive days of the week. Body composition, functional tests, immunoglobulins, muscle quality of upper and lower limbs and absolute muscular strength of the upper …

Comics For Pediatric Oncology Patients And Families: Education And Empowerment, Natalie Johns

Calvert Undergraduate Research Awards

The major objective is to develop the first book of a boxed set series of comic vignettes that will serve as a clinical educational tool for pediatric patients with a recent cancer diagnosis and their caregivers. These comics are hypothesized to improve patient and family understanding of the disease, its treatment, side effects, and outcomes in an engaging and aesthetically pleasing way. The overall goals of this project are to reduce anxiety and increase health literacy in patients and their families while assisting the oncology team in providing optimal medical care, thus improving the overall quality of treatment. Comics aimed …

Addressing The Ecological Fallacy With Lagrangian Inference, Michael Schwob

Calvert Undergraduate Research Awards

Most epidemiologists elect to use statistical models that use population-level data to make inference on the spread of some virus or disease. This has become commonplace in the fields of epidemiology and biostatistics since most data used to construct and verify epidemic models are recorded at the population-level. Obtaining inference from a population-level model may be beneficial in studying the spread of disease in a homogeneous population, but the use of such models to describe a heterogeneous population results in inadequate inference. The inaccuracy of these models is further amplified when one tries to make individual-level inference from these population-level …

Dental And Physical Therapy Faculty Collaborate In Assessing And Educating Dental Students On Musculoskeletal Disorders, Noëlle M. Santucci, Justin Jellin, Todd E. Davenport

All Faculty Scholarship

Introduction: Research shows 54% to 93% of practicing dentists suffer from musculoskeletal disorders (MSDs), with many developing afflictions early in their careers. Studies also show that dental students are developing MSDs early in their professional education. Objective: The research goal was to quantify the prevalence, anatomical location and initial onset of MSDs among first-year dental students. The study also assessed the students’ self-reported opinion as to whether there were enough educational touchpoints to improve their ergonomics in daily activities. Methods: At the conclusion of a 9-month preclinical restorative course, that included 2 lectures on MSDs, ergonomics, and postural cueing sessions, …

2018 Statewide Child Death Report, Nevada Institute For Children’S Research And Policy, Dawn L. Davidson, Elizabeth Holka

Nevada Institute for Children's Research and Policy Reports

The purpose of this report is to provide comprehensive information regarding the circumstances by which children die in Nevada in order to prevent future child deaths and improve the health and safety of children in the state.

The Creative Legal Histories Of Cervantes And Jurist Antonio De La Peña, Susan Byrne

Department of World Languages Faculty Research

In the Quijote’s intercalated novella titled El curioso impertinente, Miguel de Cervantes narrates the story of a husband inducing his best friend to seduce his wife. This study compares Cervantes’ use of juridical detail in that story with contemporaneous legal arguments and punishments for a husband who acts as procurer for his wife.

Principle Of An Acoustical Method For Estimating The Centroid Position Of The Earcanal Wall Normal Velocity Induced By Bone-Conducted Stimulation: Numerical Evaluation, Kevin Carillo, Olivier Doutres, Franck Sgard

Études primaires

The occlusion effect is commonly experienced as the altered perception of one’s own physiological noise when the earcanal entrance is blocked. Objectively, this phenomenon corresponds to an acoustic pressure increase in the occluded earcanal. The occlusion effect originates from the earcanal wall normal vibration and depends on the spatial distribution of the latter. At low frequencies, this spatial distribution can be characterized by the position of its centroid along the earcanal middle axis. This paper describes the principle of an acoustical method for estimating this centroid position at low frequencies. The proposed method consists in measuring the eardrum acoustic pressure …

Exploring The Relationship Between Grit, Work Engagement, And Career Success Among U.S. Pharmacists, Nareeta A. Sharma

University of the Pacific Theses and Dissertations

Background. Career success can be examined from an objective perspective by assessing tangible measures of success, such as salary, or from a subjective perspective by examining an individual’s reflections of their own career. While previous literature has identified characteristics of pharmacists that contribute to professional success, there is a lack in literature regarding whether certain traits or job-related characteristics may predict success.

Purpose and Objectives. The purpose of this study is to investigate the effect of grit and work engagement on career success among practicing pharmacists in the United States (U.S.). A secondary objective is to identify how pharmacists describe …

Osseointegration For Amputees: Past, Present And Future: Basic Science, Innovations In Surgical Technique, Implant Design And Rehabilitation Strategies, Munjed Al Muderis

Theses

Loss of a leg or arm is a tremendous disability. Immediate and obvious impairments are decreased mobility or diminished functional capacity. Not quite as obvious are the difficulties associated with activities of daily living, quality of life impairments, sometimes loss of independence or employment, and the mental health issues which often accompany limb loss. The interface between native tissue and the prosthetic limb presents the greatest challenge to amputee rehabilitation. Computer-controlled robotic limbs have been widely available since the 1990s. However, the weight of prosthetic limbs, coupled with the difficulty of where to locate the components, requires substantial loads to …

Martuwarra First Law Multi-Species Justice Declaration Of Interdependence: Wellbeing Of Land, Living Waters, And Indigenous Australian People, Anne Poelina

Theses

The thesis is comprised of experiential research, poetry, film and peer reviewed publications, and book chapters culminating in twelve chapters and two appendices. The study is in the Kimberley region of northern Western Australia. The study used an Indigenous decolonising research paradigm. It calls for a powerful policy and investment approach to the planning and development of regional governance. The author engaged ‘cooperative participative inquiry’ with leaders from six independent Indigenous Nations. These Nations are connected through Warloongarriy, the First Law for Martuwarra, the Fitzroy River.

First law is the spirit that connects all things and promotes multispecies justice through …

Accuracy Of Digital Impressions At Varying Implant Depths: An In-Vitro Study, Vivia Sequeira

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: Implants placed at variable depths may vary the amount of visible scannable surface of a scan body. Intraoral scanner technology uses advanced optical principles to record the surface of the scan body to accurately capture the implant position.

Purpose: To investigate the effect implant placement depth has on the accuracy of digital implant impressions using an intraoral scanner.

Materials & Methods: A partially edentulous gypsum master model was fabricated to allow the positioning of a single implant analog at different depths. Four groups based on the planned implant depths of 0, 3, 6 and 7mm and corresponding visibility of …

From Inner Segment To Outer Segment: Palmitoylation Of Photoreceptor Na+, K+-Atpase And The Importance Of Prcd In Photoreceptor Outer Segment Morphogenesis, Emily R. Sechrest

Graduate Theses, Dissertations, and Problem Reports (ETD)

Photoreceptors are specialized neuroepithelial cells which are optimized for efficient capture of light and initiation of visual transduction. These cells have several compartments which are very important for proper visual function and segregation of cellular processes, including the outer segment (OS), inner segment (IS), nucleus, and synapse. The IS houses all of the cellular organelles and biosynthetic molecular machinery the cell requires and is the site of protein synthesis. The light-sensing OS is a highly modified, primary cilium, which contains many stacks of double membranous discs which house proteins required for formation and maintenance of OS structure, as well as …