Medicine and Health Sciences Commons^™

Associations Between Fruit Intake And Risk Of Diabetes In The Ausdiab Cohort, Nicola P. Bondonno, Raymond J. Davey, Kevin Murray, Simone Radavelli-Bagatini, Catherine P. Bondonno, Lauren C. Blekkenhorst, Marc Sim, Dianna J. Magliano, Robin M. Daly, Jonathan E. Shaw, Joshua R. Lewis, Jonathan M. Hodgson

Research outputs 2014 to 2021

Context

Fruit, but not fruit juice, intake is inversely associated with type 2 diabetes mellitus (T2DM). However, questions remain about the mechanisms by which fruits may confer protection. Objective The aims of this work were to examine associations between intake of fruit types and 1) measures of glucose tolerance and insulin sensitivity and 2) diabetes at follow-up.

Methods

Among participants of the Australian Diabetes, Obesity and Lifestyle Study, fruit and fruit juice intake was assessed by food frequency questionnaire at baseline. Associations between fruit and fruit juice intake and 1) fasting plasma glucose, 2-hour postload plasma glucose, updated homeostasis model …

Supporting Patient-Clinician Interaction In Chronic Hiv Care: Design And Development Of A Patient-Reported Outcomes Software Application, Susan Herrmann, Brad Power, Amineh Rashidi, Mark Cypher, Frank Mastaglia, Amy Grace, Elizabeth Mckinnon, Pierre Sarrot, Christophe Michau, Matthew Skinner, Renae Desai, Martin Duracinsky

Research outputs 2014 to 2021

Background: The consideration of health-related quality of life (HRQL) is a hallmark of best practice in HIV care. Information technology offers an opportunity to more closely engage patients with chronic HIV infection in their long-term management and support a focus on HRQL. However, the implementation of patient-reported outcome (PRO) measures, such as HRQL in routine care, is challenged by the need to synthesize data generated by questionnaires, the complexity of collecting data between patient visits, and the integration of results into clinical decision-making processes. Objective: Our aim is to design and pilot-test a multimedia software platform to overcome these challenges …

Covid-19 Governance, Legitimacy, And Sustainability: Lessons From The Australian Experience, Michael Lester, Marie Dela Rama, Julie Crews

Research outputs 2014 to 2021

During 2020, Australia managed the global and systemic COVID-19 crisis successfully as measured by health and economic indicators. It marshalled the government’s delivery capacity to control the health crisis and put in place measures to offset the induced economic and social costs. At the same time, the crisis revealed long-standing structural weaknesses in a small, democratic, wealthy, and economically successful country that raised questions about post COVID resilience and sustainability. This paper examines that experience by applying a “co-production” governance model that sees success in “crisis management” as the striking of a balance between government capacity and its legitimacy in …

Vaccines Are Not Yet A Silver Bullet: The Imperative Of Continued Communication About The Importance Of Covid-19 Safety Measures, Zhaohui Su, Jun Wen, Dean Mcdonnell, Edmund Goh, Xiaoshan Li, Sabina Šegalo, Junaid Ahmad, Ali Cheshmehzangi, Yu-Tao Xiang

Research outputs 2014 to 2021

COVID-19 vaccines are by no means a silver bullet. With more COVID-19 vaccines expecting approval in the coming months, it is necessary to note that vaccine availability does not equate to vaccine accessibility, nor vaccine efficacy. Some research suggests that approximately 9 out of 10 individuals living in lower-income countries will not have access to COVID-19 vaccines until 2023 or later. For higher-income countries, such as the United States, the prevalence of vaccine hesitancy may further compound the situation. These insights combined, in turn, emphasize the fact that even though COVID-19 vaccines are becoming more available, safety measures (e.g., face …

Irf7-Associated Immunophenotypes Have Dichotomous Responses To Virus/Allergen Co-Exposure And Om-85-Induced Reprogramming, Emma De Jong, Jean-Francois Lauzon-Joset, Jonatan Leffler, Michael Serralha, Alexander N. Larcombe, Claus T. Christophersen, Patrick G. Holt, Deborah H. Strickland, Anthony Bosco

Research outputs 2014 to 2021

High risk for virus-induced asthma exacerbations in children is associated with an IRF7loimmunophenotype, but the underlying mechanisms are unclear. Here, we applied aSystems Biology approach to an animal model comprising rat strains manifesting high(BN)versuslow susceptibility (PVG) to experimental asthma, induced by virus/allergencoexposure, to elucidate the mechanism(s)-of-action of the high-risk asthmaimmunophenotype. We also investigated potential risk mitigationviapretreatment withthe immune training agent OM-85. Virus/allergen coexposure in low-risk PVG rats resultedin rapid and transient airways inflammation alongside IRF7 gene network formation. Incontrast, responses in high-risk BN rats were characterized by severe airways eosinophiliaand exaggerated proinflammatory responses that failed to resolve, and complete absenceof …

Current Perspective On The Therapeutic Preset For Substance-Assisted Psychotherapy, Sascha B. Thal, Stephen J. Bright, Jason M. Sharbanee, Tobias Wenge, Petra M. Skeffington

Research outputs 2014 to 2021

The present narrative review is the first in a series of reviews about the appropriate conduct in substance-assisted psychotherapy (SAPT). It outlines a current perspective on preconditions and theoretical knowledge that have been identified as valuable in the literature for appropriate therapeutic conduct in SAPT. In this context, considerations regarding ethics and the spiritual emphasis of the therapeutic approaches are discussed. Further, current methods, models, and concepts of psychological mechanism of action and therapeutic effects of SAPT are summarized, and similarities between models, approaches, and potential mediators for therapeutic effects are outlined. It is argued that a critical assessment of …

Vitamin K Intake And Atherosclerotic Cardiovascular Disease In The Danish Diet Cancer And Health Study, Jamie W. Bellenge, Frederik Dalgaard, Kevin Murray, Emma Connolly, Lauren C. Blekkenhorst, Catherine P. Bondonno, Joshua R. Lewis, Marc Sim, Kevin D. Croft, Gunnar Gislason, Christian Torp-Pedersen, Anne Tjønneland, Kim Overvad, Jonathan M. Hodgson, Carl Schultz, Nicola P. Bondonno

Research outputs 2014 to 2021

Background Dietary vitamin K (K1 and K2) may reduce atherosclerotic cardiovascular disease (ASCVD) risk via several mechanisms. However, studies linking vitamin K intake with incident ASCVD are limited. We aimed to determine the relationship between dietary vitamin K intake and ASCVD hospitalizations. Methods and Results In this prospective cohort study, participants from the Danish Diet, Cancer, and Health Study, with no prior ASCVD, completed a food‐frequency questionnaire at baseline and were followed up for hospital admissions of ASCVD; ischemic heart disease, ischemic stroke, or peripheral artery disease. Intakes of vitamin K1 and vitamin K2 were estimated from the food‐frequency questionnaire, …

Intake Of Products Containing Anthocyanins, Flavanols, And Flavanones, And Cognitive Function: A Narrative Review, Samantha L. Gardener, Stephanie R. Rainey-Smith, Michael Weinborn, Catherine P. Bondonno, Ralph N. Martins

Research outputs 2014 to 2021

The purpose of this review is to examine human research studies published within the past 6 years which evaluate the role of anthocyanin, flavanol, and flavanone consumption in cognitive function, and to discuss potential mechanisms of action underlying any observed benefits. Evidence to date suggests the consumption of flavonoid-rich foods, such as berries and cocoa, may have the potential to limit, or even reverse, age-related declines in cognition. Over the last 6 years, the flavonoid subgroups of anthocyanins, flavanols, and flavanones have been shown to be beneficial in terms of conferring neuroprotection. The mechanisms by which flavonoids positively modulate cognitive …

Inconsistent Use Of Resistance Exercise Names In Research Articles: A Brief Note, James L. Nuzzo

Research outputs 2014 to 2021

Academic fields require standard nomenclature to communicate concepts effectively. Previous research has documented resistance training exercises are named inconsistently. This inconsistent use has been observed among fitness professionals and within resistance training textbooks. The purpose of the current note was to explore inconsistent use of resistance training exercise names in scientific articles. Keyword searches were performed in PubMed to identify articles that referred to 4 different resistance training exercises. The search was limited to titles and abstracts of articles published between 1960 and 2020. For exercise 1, "shoulder press," "overhead press," and "military press" were searched. For exercise 2, "arm …

Cannabinoid Exposure As A Major Driver Of Pediatric Acute Lymphoid Leukaemia Rates Across The Usa: Combined Geospatial, Multiple Imputation And Causal Inference Study, Albert Stuart Reece, Gary K. Hulse

Research outputs 2014 to 2021

Background: Acute lymphoid leukaemia (ALL) is the commonest childhood cancer whose incidence is rising in many nations. In the USA, between 1975 and 2016, ALL rates (ALLRs) rose 93.51% from 1.91 to 3.70/100,000 < 20 years. ALL is more common in Caucasian-Americans than amongst minorities. The cause of both the rise and the ethnic differential is unclear, however, prenatal cannabis exposure was previously linked with elevated childhood leukaemia rates. We investigated epidemiologically if cannabis use impacted nationally on ALLRs, its ethnic effects, and if the relationship was causal. Methods: State data on overall, and ethnic ALLR from the Surveillance Epidemiology and End Results databank of the Centre for Disease Control (CDC) and National Cancer Institute (NCI) were combined with drug (cigarettes, alcoholism, cannabis, analgesics, cocaine) use data from the National Survey of Drug Use and Health; 74.1% response rate. Income and ethnicity data was from the US Census bureau. Cannabinoid concentration was from the Drug Enforcement Agency Data. Data was analyzed in R by robust and spatiotemporal regression. Results: In bivariate analyses a dose-response relationship was demonstrated between ALLR and Alcohol Use Disorder (AUD), cocaine and cannabis exposure, with the effect of cannabis being strongest (β-estimate = 3.33(95%C.I. 1.97, 4.68), P = 1.92 × 10− 6). A strong effect of cannabis use quintile on ALLR was noted (Chi.Sq. = 613.79, P = 3.04 × 10− 70). In inverse probability weighted robust regression adjusted for other substances, income and ethnicity, cannabis was independently significant (β-estimate = 4.75(0.48, 9.02), P = 0.0389). In a spatiotemporal model adjusted for all drugs, income, and ethnicity, cannabigerol exposure was significant (β-estimate = 0.26(0.01, 0.52), P = 0.0444), an effect increased by spatial lagging (THC: β-estimate = 0.47(0.12, 0.82), P = 0.0083). After missing data imputation ethnic cannabis exposure was significant (β-estimate = 0.64(0.55, 0.72), P = 3.1 × 10− 40). 33/35 minimum e-Values ranged from 1.25 to 3.94 × 1036 indicative of a causal relationship. Relaxation of cannabis legal paradigms had higher ALLR (Chi.Squ.Trend = 775.12, P = 2.14 × 10− 112). Cannabis legal states had higher ALLR (2.395 ± 0.039 v. 2.127 ± 0.008 / 100,000, P = 5.05 × 10− 10). Conclusions: Data show that ALLR is associated with cannabis consumption across space-time, is associated with the cannabinoids, THC, cannabigerol, cannabinol, cannabichromene, and cannabidiol, contributes to ethnic differentials, demonstrates prominent quintile effects, satisfies criteria for causality and is exacerbated by cannabis legalization.

Adaptations To Post-Exercise Cold Water Immersion: Friend, Foe, Or Futile?, Mohammed Ihsan, Chris R. Abbiss, Robert Allan

Research outputs 2014 to 2021

In the last decade, cold water immersion (CWI) has emerged as one of the most popular post-exercise recovery strategies utilized amongst athletes during training and competition. Following earlier research on the effects of CWI on the recovery of exercise performance and associated mechanisms, the recent focus has been on how CWI might influence adaptations to exercise. This line of enquiry stems from classical work demonstrating improved endurance and mitochondrial development in rodents exposed to repeated cold exposures. Moreover, there was strong rationale that CWI might enhance adaptations to exercise, given the discovery, and central role of peroxisome proliferator-activated receptor gamma …

Influence Of The Covid-19 Pandemic On Mood And Training In Australian Community Tennis Players, Mitchell Turner, Philipp Beranek, Shane L. Rogers, Kazunori Nosaka, Olivier Girard, Travis Cruickshank

Research outputs 2014 to 2021

The COVID-19 outbreak has led to the implementation of strict restrictions in Australia, which have severely impacted sporting activities. Tennis is played by 6.2% of the population within the Oceania region, and is a valuable sport for maintaining social, mental, and physical health. Current literature indicates the COVID-19 pandemic has negatively affected the mental health of Australian residents. The aim of this study was to investigate changes in training and match play due to the outbreak, and its effects on emotional well-being of Australian senior tennis players. Additionally, explore any differences between middle aged (41-60 years) and senior (61 years …

Kinematic And Neuromuscular Measures Of Intensity During Drop Jumps In Female Volleyball Players, Maximiliano Torres-Banduc, Rodrigo Ramirez-Campillo, David Cristobal Andrade, Julio Calleja-González, Pantelis Theo Nikolaidis, John J. Mcmahon, Paul Comfort

Research outputs 2014 to 2021

The aim of this study was to assess drop jump (DJ) performance variables (jump height, contact time, and reactive strength index) concomitant to surface electromyography (sEMG) of lower limb muscles during DJs from different drop heights (intensities). The eccentric and concentric phase sEMG from the gastrocnemius medialis, biceps femoris, and vastus medialis muscles were assessed during all tests, with sEMG activity normalized to maximal voluntary isometric contraction (MVIC). In a cross-sectional, study, 10 amateur female volleyball players (age 22.1 ± 1.8 years; body mass 72.9 ± 15.2 kg; height 1.70 ± 0.08 m) completed DJs from six heights [15-90 cm …

Joint Angles In Elbow Flexor Unilateral Resistance Exercise Training Determine Its Effects On Muscle Strength And Thickness Of Trained And Non-Trained Arms, Shigeru Sato, Riku Yoshida, Ryosuke Kiyono, Kaoru Yahata, Koki Yasaka, João Pedro Nunes, Kazunori Nosaka, Masatoshi Nakamura

Research outputs 2014 to 2021

The present study compared two unilateral arm curl resistance exercise protocols with a different starting and finishing elbow joint angle in the same ROM for changes in elbow flexors strength and muscle thickness of the trained and non-trained arms. Thirty-two non-resistance trained young adults were randomly assigned to one of the three groups: extended joint training (0°-50°; EXT, = 12); flexed joint training (80°-130°; FLE, = 12); and non-training control ( = 8). The exercise training was performed by the dominant arms twice a week for 5 weeks with gradual increases in the training volume over 10 training sessions, and …

The Development Of Aboriginal Brain Injury Coordinator Positions: A Culturally Secure Rehabilitation Service Initiative As Part Of A Clinical Trial, Elizabeth Armstrong, Kathy Mccoy, Rebecca Clinch, Maureen Merritt, Renee Speedy, Meaghan Mcallister, Kym Heine, Natalie Ciccone, Melanie Robinson, Julie Coffin

Research outputs 2014 to 2021

Brain injury, resulting from stroke and traumatic brain injury, is a common occurrence in Australia, with Aboriginal people affected at a significant rate and impact felt by individuals, families and communities. Access to brain injury rehabilitation services for Aboriginal people is reported to be often limited, with very little support outside the hospital environment. Our research involving Aboriginal brain injury survivors and their families to date has revealed that people often manage ‘on their own’ following such events. Following recommendations from survivors and their families, the Healing Right Way clinical trial, currently underway in Western Australia, has created the role …

A Delirium Prevalence Audit And A Pre And Post Evaluation Of An Interprofessional Education Intervention To Increase Staff Knowledge About Delirium In Older Adults, Bev Ewens, Karla Seaman, Lisa Whitehead, Mandy Towell-Barnard, Michelle Young

Research outputs 2014 to 2021

Background

Delirium is more prevalent in older people and estimated to occur in up to 50% of the hospital population. Delirium comprises a spectrum of behaviours, including cognitive and attention deficits, and fluctuating levels of consciousness, often associated with an underlying physiological disturbance. Delirium has been increasingly associated with adverse outcomes. Although often preventable or can at least be mitigated, delirium may not be a standard part of assessment and thus may not be recognized in the early stages when it is most likely to be treated successfully. The aim of this study was to evaluate the level of knowledge …

Whole Fat Dairy Products Do Not Adversely Affect Adiposity Or Cardiometabolic Risk Factors Inchildren In The Milky Way Study: A Double Blind Randomized Controlled Pilot Study, Analise Nicholl, Kane Deering, Kate J. Evelegh, Philippa Lyons-Wall, David Lawrence, Trevor A. Mori, Mario Kratz, Therese O'Sullivan

Research outputs 2014 to 2021

Background

Limited evidence supports the common public health guideline that children > 2 y of age should consume dairy with reduced fat content.

Objectives

We aimed to investigate the effects of whole-fat compared with reduced-fat dairy intake on measures of adiposity and biomarkers of cardiometabolic risk in healthy 4- to 6-y-old children.

Methods

The Milky Way Study enrolled 49 children (mean ± SD age: 5.2 ± 0.9 y; 47% girls) who were habitual consumers of whole-fat dairy, then randomly assigned them in a double-blind fashion to remain on whole-fat dairy or switch their dairy consumption to reduced-fat products for 3 mo. …

Early Childhood Caries, Primary Caregiver Oral Health Knowledge And Behaviours And Associated Sociological Factors In Australia: A Systematic Scoping Review, Lesley Andrew, Ruth M. Wallace Mrs, Nicole Wickens, Jilen Patel

Research outputs 2014 to 2021

Background

Early childhood caries disproportionately affects vulnerable groups and remains a leading cause of preventable hospital admissions for Western Australian children. The Western Australia State Oral Health Plan seeks to improve child oral health through universal and targeted health promotion initiatives with primary caregivers. These initiatives require evidence of primary caregiver oral health knowledge and behaviours and baseline data on early childhood caries. The objective of this systematic scoping review was to understand current oral health knowledge and practices of primary caregivers of children aged 0–4 years, identify influential socioecological determinants, and identify data on early childhood caries in the …

The Psychosocial Impact Of Rare Diseases Among Children And Adolescents Attending Mainstream Schools In Western Australia, Esther A. Adama, Diana Arabiat, Mandie Foster, Ebenezer Afrifa-Yamoah, K. Runions, R. Vithiatharan, A. Lin

Research outputs 2014 to 2021

Living with a long-term medical condition is associated with heightened risk for mental health and psychosocial difficulties, but further research is required on this risk for children and adolescents with a rare disease in the educational setting. The aim of this study is to describe parents’ perceptions of the psychosocial impact of rare diseases on their school-aged children in Western Australia. A cross-sectional survey of 41 parents of school-aged children and adolescents diagnosed with a rare disease completed an online questionnaire. Questions related to their perceptions of health-related stigma, bullying, social competencies and mental health difficulties faced by their child. …

A Survey To Evaluate The Association Of Covid-19 Restrictions On Perceived Mood And Coping In Australian Community Level Athletes, Caitlin Fox-Harding, Sarah A. Harris, Shane L. Rogers, Shayne Vial, Philipp Beranek, Mitchell Turner, Travis Cruickshank

Research outputs 2014 to 2021

Australian community level athletes faced unprecedented changes to their training andcompetition options as the global COVID-19 pandemic took a stronghold. This disruptionwas predicted to have a negative impact on emotional well-being as communitiesbraced through periods of social isolation and physical distancing requirements. Thisstudy provides an Australian perspective on the emotional well-being of communitylevel athletes and the extent to which they coped during the COVID-19 pandemic.Emotional well-being and coping were measured using the Brief Emotional ExperienceScale and the 28-item Brief Cope Scale. Both instruments were administered alongwith other questions pertaining to participant demographics and training status via anonline survey between April …

Creating A Theoretical Framework To Underpin Discourse Assessment And Intervention In Aphasia, Lucy Dipper, Jane Marshall, Mary Boyle, Deborah Hersh, Nicola Botting, Madeline Cruice

Research outputs 2014 to 2021

Discourse (a unit of language longer than a single sentence) is fundamental to everyday communication. People with aphasia (a language impairment occurring most frequently after stroke, or other brain damage) have communication difficulties which lead to less complete, less coherent, and less complex discourse. Although there are multiple reviews of discourse assessment and an emerging evidence base for discourse intervention, there is no unified theoretical framework to underpin this research. Instead, disparate theories are recruited to explain different aspects of discourse impairment, or symptoms are reported without a hypothesis about the cause. What is needed is a theoretical framework that …

The Role Of C-Reactive Protein And Fibrinogen In The Development Of Intracerebral Hemorrhage: A Mendelian Randomization Study In European Population, Biyan Wang, Xiaoyu Zhang, Di Liu, Jie Zhang, Mingyang Cao, Xin Tian, Isinta E. Maranga, Xiaoni Meng, Qiuyue Tian, Feifei Tian, Weijie Cao, Wei Wang, Manshu Song, Youxin Wang

Research outputs 2014 to 2021

Background: The causal association of C-reactive protein (CRP) and fibrinogen on intracerebral hemorrhage (ICH) remains uncertain. We investigated the causal associations of CRP and fibrinogen with ICH using two-sample Mendelian randomization. Method: We used single-nucleotide polymorphisms associated with CRP and fibrinogen as instrumental variables. The summary data on ICH were obtained from the International Stroke Genetics Consortium (1,545 cases and 1,481 controls). Two-sample Mendelian randomization estimates were performed to assess with inverse-variance weighted and sensitive analyses methods including the weighted median, the penalized weighted median, pleiotropy residual sum and outlier (MR-PRESSO) approaches. MR-Egger regression was used to explore the pleiotropy. …

Communicating With Older People About Physical Activity, Simone Pettigrew, Michelle I. Jongenelis, Rajni Rai, Ben Jackson, Robert U. Newton

Research outputs 2014 to 2021

Objective: Little is known about how to effectively encourage higher levels of activity among older people. This study tested the effectiveness of a public service advertisement designed according to recommendations for communicating with older audiences and featuring five types of moderate-to-vigorous physical activity: tennis, line dancing, cycling, swimming and jogging. Methods: A survey administered to 1,200 Australians aged 50+ years assessed effects of the public service advertisement on: motivation (intrinsic and extrinsic); perceived believability, relevance, and effectiveness; and feelings elicited (e.g. interest, hope, guilt). Open-ended questions enabled respondents to describe aspects of the ad they considered to be most and …

Feasibility, Safety, And Acceptability Of A Remotely Monitored Exercise Pilot Champ: A Clinical Trial Of High-Intensity Aerobic And Resistance Exercise For Metastatic Castrate-Resistant Prostate Cancer, Stacey A. Kenfield, Erin L. Van Blarigan, Neil Panchal, Alexander Bang, Li Zhang, Rebecca E. Graff, Yea-Hung Chen, Charles J. Ryan, Anthony Luke, Robert U. Newton, Imelda Tenggara, Brooke Schultz, Elizabeth Wang, Emil Lavaki, Kyle Zuniga, Nicole Pinto, Hala Borno, Rahul Aggarwal, Terence Friedlander, Vadim S. Koshkin, Andrea Harzstark, Eric Small, June M. Chan

Research outputs 2014 to 2021

Background: Exercise may improve clinical and quality of life outcomes for men with prostate cancer. No randomized controlled trials (RCTs) have examined the feasibility, safety, and acceptability of remote exercise training in men with metastatic castrate-resistant prostate cancer (mCRPC). Methods: We conducted a pilot RCT (1:1:1 aerobic or resistance exercise 3x/week or usual care) to determine the feasibility, safety, and acceptability of remotely monitored exercise over 12 weeks in 25 men with mCRPC. A prescribed exercise program was based on baseline testing including high- and moderate-intensity aerobic exercise or resistance exercise completed at a local exercise facility. Feasibility was based …

Risk Factors For Gut Dysbiosis In Early Life, Kimberley Parkin, Claus T. Christophersen, Valerie Verhasselt, Matthew N. Cooper, David Martino

Research outputs 2014 to 2021

Dysbiosis refers to a reduction in microbial diversity, combined with a loss of beneficial taxa, and an increase in pathogenic microorganisms. Dysbiosis of the intestinal microbiota can have a substantial effect on the nervous and immune systems, contributing to the onset of several inflammatory diseases. Epidemiological studies provided insight in how changes in the living environment have contributed to an overall loss of diversity and key taxa in the gut microbiome, coinciding with increased reports of atopy and allergic diseases. The gut microbiome begins development at birth, with major transition periods occurring around the commencement of breastfeeding, and the introduction …

Therapeutic Potential Of Mitophagy-Inducing Microflora Metabolite, Urolithin A For Alzheimer’S Disease, Dona Pamoda W. Jayatunga, Eugene Hone, Harjot Khaira, Taciana Lunelli, Harjinder Singh, Gilles J. Guillemin, Binosha Fernando, Manohar L. Garg, Giuseppe Verdile, Ralph N. Martins

Research outputs 2014 to 2021

Mitochondrial dysfunction including deficits of mitophagy is seen in aging and neuro-degenerative disorders including Alzheimer’s disease (AD). Apart from traditionally targeting amyloid beta (Aβ), the main culprit in AD brains, other approaches include investigating impaired mitochondrial pathways for potential therapeutic benefits against AD. Thus, a future therapy for AD may focus on novel candidates that enhance optimal mitochondrial integrity and turnover. Bi-oactive food components, known as nutraceuticals, may serve as such agents to combat AD. Uro-lithin A is an intestinal microbe-derived metabolite of a class of polyphenols, ellagitannins (ETs). Urolithin A is known to exert many health benefits. Its antioxidant, …

An Assessment Of The Hopping Strategy And Inter-Limb Asymmetry During The Triple Hop Test: A Test–Retest Pilot Study, Kyle Davey, Paul Read, Joseph Coyne, Paul Jarvis, Anthony Turner, Jon Brazier, Nejc Šarabon, Matthew J. Jordan, Chris Bishop

Research outputs 2014 to 2021

The aims of the present study are to: (1) determine within-and between-session reliability of multiple metrics obtained during the triple hop test; and (2) determine any systematic bias in both the test and inter-limb asymmetry scores for these metrics. Thirteen male young American football athletes performed three trials of a triple hop test on each leg on two separate occasions. In addition to the total distance hopped, manual detection of touch down and toe-off were calculated via video analysis, enabling flight time (for each hop), ground contact time (GCT), reactive strength index (RSI), and leg stiffness (between hops) to be …

Principle-Based Concept Analysis Methodology Using A Phased Approach With Quality Criteria, Stephanie Smith, Evalotte Mörelius

Research outputs 2014 to 2021

The study aimed to provide a detailed description of a process to conduct a phased principle-based concept analysis and to introduce quality criteria assessment for a phased principle-based concept analysis. Concept analysis explores how a concept is described, used and measured in the literature. This conceptual understanding is important to guide translational research to direct the development of evidence-based practice. The principle-based concept analysis is one approach of concept analysis used in published work, but the literature is lacking in articles clearly describing how to conduct it in practice. This article provides a methodology utilising a phased approach and by …

Critical Implications Of M-Payments Use On Healthcare, Jing Zhou, Jo Jung, Yi Lin

Research outputs 2014 to 2021

With m-payment, consumers could now operate cashless by providing an easy and convenient way to pay for products and services. The adoption of m-payment technologies and apps has been mixed, promoting many kinds of research. The studies explore factors, and their impacts influence the intention to use m-payments in China and thus affect the adoption of the same technology.

Predictive Model And Feature Importance For Early Detection Of Type Ii Diabetes Mellitus, Eric Adua, Emmanuel A. Kolog, Ebenezer Afrifa-Yamoah, Bright Amankwah, Christian Obirikorang, Enoch O. Anto, Emmanuel Acheampong, Wei Wang, Antonia Y. Tetteh

Research outputs 2014 to 2021

Background: Accurate prediction and early recognition of type II diabetes (T2DM) will lead to timely and meaningful interventions, while preventing T2DM associated complications. In this context, machine learning (ML) is promising, as it can transform vast amount of T2DM data into clinically relevant information. This study compares multiple ML techniques for predictive modelling based on different T2DM associated variables in an African population, Ghana. Methods: The study involved 219 T2DM patients and 219 healthy individuals who were recruited from the hospital and the local community, respectively. Anthropometric and biochemical information including glycated haemoglobin (HbA1c), body mass index (BMI), blood pressure, …