Medicine and Health Sciences Commons^™

Cognitive Rehearsal, Self-Efficacy, And Workplace Incivility Among Baccalaureate Nursing Students, Alina Diaz-Cruz

Electronic Theses and Dissertations, 2020-2023

Workplace incivility is a widespread problem in the clinical work environment that affects present and future generations of nurses. The purpose of this study was to determine if a cognitive rehearsal intervention (i.e., TeamSTEPPS® DESC script) would increase senior nursing students' self-efficacy, decrease workplace incivility experienced in the clinical work environment, and if nursing students' pre-intervention self-efficacy level would be indirectly associated with post-intervention workplace incivility. A quasi-experimental, one-group pretest-posttest study was used to measure the effect of a cognitive rehearsal intervention on nursing students' self-efficacy levels and workplace incivility experienced in their clinical rotation at an acute care center. …

Chitosan-Gallium Nanocomposite: Synthesis, Characterization And Antibacterial Activity, Samjhana Bhandari

Electronic Theses and Dissertations, 2020-2023

The emergence of multidrug-resistant (MDR) strains of bacteria and the lack of a novel class of antibiotics has become a global health concern. Pseudomonas aeruginosa is one common MDR bacteria responsible for nosocomial infections and related mortality worldwide. It has developed resistance against commonly available antibiotics and is in the WHO's priority list of bacteria for which new antibiotics are desperately needed. Currently there is a growing interest in developing metal and non-metal-based nanoparticles to target multidrug-resistant bacteria. The objective of this study is to evaluate the efficacy of a novel nanocomposite of two non-traditional antimicrobials: a metal (Ga-III) and …

Influence Of Geography On The Healthy Gut Microbiome And The Role Of The Gut Microbiome In Ibd Symptom And Disease Progression, Sayf Al-Deen Hassouneh

Electronic Theses and Dissertations, 2020-2023

The human gut microbiome is believed to play an integral role in host health and disease. In a microbial community, associations between constituent members play an important role in determining the overall structure and function of the community. To understand the nature of bacterial associations at the species level in healthy human gut microbiomes, we analyzed previously published collections of whole-genome shotgun sequence data, from fecal samples obtained from four different healthy human populations. Using a Random Forest Classifier, we identified bacterial species that were prevalent in these populations and whose relative abundances could be used to accurately distinguish between …

Educating Nursing Students Through The Pandemic: The Essentials Of Collaboration, Audrey M. Beauvais, Meredith Kazer, Lisa M. Rebeschi, Rosemarie Baker, Jeanette H. Lupinacci

St. Vincent’s College Faculty publications

Introduction: Throughout the COVID-19 pandemic, meeting regulatory educational requirements and graduating students competent for nursing practice was essential. Competent graduates were needed to support a strong nursing workforce in Connecticut during this chaotic time in health care. This paper describes the powerful impact of statewide collaboration toward meeting this goal.

Methods: The Connecticut League for Nursing Council of Deans and Directors (Council) organized six work groups to address the practice issues brought about by COVID-19 to continue educating nursing students and ensure a robust nursing workforce for the state. Volunteers from the Council offered to lead the groups and members …

Abate The Stress! The Development And Implementation Of A New Medication Exam For Newly Hired Nurses, Nicole Wiswesser Rn

Patient Care Services / Nursing

No abstract provided.

The Impact Of The 2018 Kentucky Cigarettes Taxes On Tobacco Use Among Youth, Claire W. Mampunza

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Introduction: In the Commonwealth of Kentucky, cigarette smoking results in 1.92 billion dollars spent every year on medical costs, the death of approximately 9,000 Kentuckians, and 34 percent of all cancer cases. In 2017, 14.3 percent of high school students in Kentucky declared being current cigarette smokers, compared to 8.8 percent nationally. Tobacco use among youth is a public health concern because 88 percent of adult smokers initiate smoking before age 18. Youth nicotine use can damage the growing brain, which continues to develop until 25 years of age. In July 2018, the excise tax on cigarettes increased from …

Effect Of Histone H4 Tail On Nucleosome Stability And Internucleosomal Interactions, Tommy Stormberg, Sridhar Vemulapalli, Shaun Filliaux, Yuri L. Lyubchenko

Journal Articles: Pharmaceutical Sciences

Chromatin structure is dictated by nucleosome assembly and internucleosomal interactions. The tight wrapping of nucleosomes inhibits gene expression, but modifications to histone tails modulate chromatin structure, allowing for proper genetic function. The histone H4 tail is thought to play a large role in regulating chromatin structure. Here we investigated the structure of nucleosomes assembled with a tail-truncated H4 histone using Atomic Force Microscopy. We assembled tail-truncated H4 nucleosomes on DNA templates allowing for the assembly of mononucleosomes or dinucleosomes. Mononucleosomes assembled on nonspecific DNA led to decreased DNA wrapping efficiency. This effect is less pronounced for nucleosomes assembled on positioning …

Patient-Derived Induced Pluripotent Stem Cell Models For Phenotypic Screening In The Neuronal Ceroid Lipofuscinoses, Ahmed Morsy, Angelica V. Carmona, Paul C. Trippier

Journal Articles: Pharmaceutical Sciences

Batten disease or neuronal ceroid lipofuscinosis (NCL) is a group of rare, fatal, inherited neurodegenerative lysosomal storage disorders. Numerous genes (CLN1-CLN8, CLN10-CLN14) were identified in which mutations can lead to NCL; however, the underlying pathophysiology remains elusive. Despite this, the NCLs share some of the same features and symptoms but vary in respect to severity and onset of symptoms by age. Some common symptoms include the progressive loss of vision, mental and motor deterioration, epileptic seizures, premature death, and in the rare adult-onset, dementia. Currently, all forms of NCL are fatal, and no curative treatments are available. Induced pluripotent stem …

Blue Light And Adult Sleep Outcomes, Andrew Caddas

Undergraduate Distinction Papers

This study investigated the effects blue light from self-luminous devices has on adult sleeping patterns. We investigated sleep quality and duration qualitatively with a randomized, double-blind, cross-over, placebo-controlled design with a wash-out period. Participants wore blue light blocking lenses or placebo lenses whenever they were using a self-luminous device throughout each day for one week. Each morning, participants filled out a survey to report their number of hours slept, time to fall asleep, and amount of time spent on self-luminous devices. Participants took the Pittsburgh Insomnia Rating Scale (PIRS) at the end of the one week trial (See Appendix A). …

Assessing Changes In The Epidemiology Of Cutaneous Leishmaniasis In Southwest Colombia Following The Peace Accord With Fuerzas Armadas Revolucionarias De Colombia (Farc), Matthew Stephen Benczkowski

Public Health Theses

The Colombian Conflict persisted for over 50 years, recently coming to an end in November 2016 after the signing of Colombia’s Peace Agreement between the government and FARC guerrilla group. Internal armed conflict is often entangled with the exacerbation of health outcomes, including promoting the spread of infectious diseases like cutaneous leishmaniasis (CL). CL is a vector-borne parasitic disease localized to the human tegument that decreases quality of life through lesions leading to scars and associated stigmatization. This study assessed changes in demographic and clinical characteristics of patients with CL in Southwest Colombia before and after the signing of the …

The Utility Of A Maximum Entropy Species Distribution Model For Ixodes Scapularis In Predicting The Public Health Risk Of Lyme Disease In Ontario, Canada, Holly Alexandra Burrows

Public Health Theses

Introduction: Lyme disease is an emerging public health threat in Ontario, Canada due to the range expansion of the tick vector, Ixodes scapularis. Tick abundance and density are important predictors of human Lyme disease risk and are typically measured using active tick surveillance (dragging). New cost-effective tools are needed to augment current surveillance activities.Objective: The objective of this study was to evaluate the ability of a Maximum entropy species distribution model to predict I. scapularis density and abundance in three regions of Ontario – Ottawa, Kingston, and southern Ontario – in order to determine its utility in predicting the public …

Exploring Thai Physicians’ Perceptions Of And Willingness To Prescribe Pre-Exposure Prophylaxis (Prep), Brandi E. Moore

Public Health Theses

Background: Oral pre-exposure prophylaxis (PrEP) is a daily medication that can prevent HIV infection. PrEP may further support HIV prevention initiatives in Thailand, particularly as it becomes more accessible in the country’s government clinics and hospitals. While studies have explored perceptions of PrEP for at-risk people in Thailand, there has been limited investigation into Thai physicians’ opinions of and willingness to prescribe PrEP. Methods: Using convenience sampling, this cross-sectional study recruited 132 Thai physicians to complete an anonymous, online survey. The survey assessed physicians’ concerns about PrEP, experience with PrEP, and willingness to prescribe PrEP. Bivariate and multivariable logistic regressions …

Improving Emergency Department Quality Of Care, Carmen Smith

Doctor of Nursing Practice Projects

Emergency department (ED) crowding can cause an extended length of stay (LOS) and high rates of patients who leave without being seen (LWBS). This quality improvement ED project sought to reduce LOS and LWBS by implementing a triage (PIT) team. The design included an outcomes evaluation with available data and a staff pre and posttest. Length of stay and LWBS rates were compared before and after implementation. Results indicated a reduction in the average LOS and LWBS rates for the 30 days of project implementation compared to the 30 days before the project initiation. The overall goal of the PIT …

Developing An End-Of-Life Discussion Protocol In Primary Care Clinics, James L. Hawley

Doctor of Nursing Practice Projects

End-of-life (EOL) issues are far too often addressed reactively in Emergency Departments when patients can no longer express their wishes. This scenario can result in unwanted futile care, increased healthcare costs, and emotional hardships for family and healthcare workers. The purpose of this quality improvement project was to implement a protocol that would shift advanced directive conversations proactively back into primary health care settings. This action would allow patients to make and document informed decisions with their Primary Care Providers (PCPs). A pilot study conducted in November 2020 at a rural clinic provided feedback from PCPs on perceived barriers to …

Student Registered Nurse Anesthetist Perspective On The Impact Of A Clinical Mentoring Program, Sheila M. Mccarley

Doctor of Nursing Practice Projects

There is a competitive push for recruiting and retaining the Student Registered Nurse Anesthetist (SRNA) graduate. Retention efforts begin with their first clinical experience. Mentoring in the clinical setting is a critical factor in influencing the student nurse anesthetist's retention to practice. The purpose of this project was to assess whether mentoring in the local setting noted similar findings. The method involved a survey of student nurse anesthetists queried about perspectives on a clinical-based mentorship program. Certified Registered Nurse Anesthetist (CRNA) faculty members vetted the survey instrument before implementation. The project focused on students presently enrolled in their first-year clinical …

Local Impact Of Implementing Multimodal Anesthesia For Total Joint Arthroplasty, Mary Christine Gilliland

Doctor of Nursing Practice Projects

The opioid epidemic is at a critical point in the United States. This quality improvement project aims to determine which anesthesia strategies lessen the use of opioids in the surgical setting to reduce this raging epidemic. The process included total knee replacement record reviews. Reviews used general linear models to compare two multimodal anesthetic plans, including pre-medications in addition to an adductor canal and subarachnoid nerve block. The researcher reviewed the records for these patients comparing those receiving only an adductor canal and those receiving a subarachnoid nerve block. The record reviews identified postoperative pain level documentation and hospital inpatient …

Implementation Of An Evidence-Based Copd Screening Tool In Primary Care, Randi Davis

Doctor of Nursing Practice Projects

Chronic obstructive pulmonary disease (COPD) is one of the most common chronic illnesses encountered in primary health care, with more than 16 million identified cases and many more undiagnosed. The condition is frequently not diagnosed until later stages due to its insidious onset. Once diagnosed, the disease is often inadequately treated. The purpose of this quality improvement project was to implement an evidence-based practice tool. The project team selected the COPD Assessment Tool [CAT], which ensured Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines. The device provided screening for individuals "at-risk" or with a known diagnosis of COPD. The …

The Role Of Vocal Hostility On Mood: Initial Development Of An Alternative Stress Paradigm, Jaquoy Sowell, Jennifer Gray, Christa C. Christ

University of South Carolina Upstate Student Research Journal

Maltreatment, such as physical or emotional abuse, can alter one’s later emotional regularity and responses to stimuli. To be able to study the effect of maltreatment on later stimuli response, appropriate laboratory paradigms need to be available, which is not currently true. The purpose of the study was to investigate the effect of vocal hostility stimuli on mood change as preliminary steps toward the creation of a laboratory paradigm. Participants were recruited from a regional university in southeast United States and asked to react to recorded audio with a hostile tone. Study 1 found that participants’ mood did not differ …

Treatment Of Sars-Cov-2 Pneumonia With Favipiravir: Early Results From The Egeuniversity Cohort, Turkey, Hüseyi̇n Aytaç Erdem, Pervi̇n Korkmaz Ekren, Derya Çağlayan, Meltem Taşbakan, Tansu Yamazhan, Mehmet Sezai̇ Taşbakan, Abdullah Sayiner, Ayşe Deni̇z Gökengi̇n

Turkish Journal of Medical Sciences

Background/aim: The aim of this descriptive article is to share the experience in Ege University, Turkey with favipiravir in the treatment of severe SARS-CoV-2 pneumonia. Materials and methods: This retrospective descriptive study included patients diagnosed with COVID-19 who presented with or developed severe pneumonia. Results: Forty patients who completed a full course (at least 5 days) of favipiravir were included in the study. At baseline, 30 (75%) patients required treatment for respiratory distress. Thirty-three patients (82.5%) were discharged from the hospital with full recovery, 6 patients (15%) died and 1 case (2.5%) was still at the intensive care unit (ICU) …

Comparison Of Greater Occipital Nerve And Greater Occipital Nerve + Supraorbital Nerveblock Effect In Chronic Medication Overuse Headache, Nermi̇n Tepe, Oktay Faysal Tertemi̇z

Turkish Journal of Medical Sciences

Background /aim: In this study, we aimed to compare the efficacy of greater occipital nerve (GON) block alone and GON combined with supraorbital nerve (SON) block in the treatment of medication overuse headache (MOH). Material and methods: 82 patients were divided into two groups: 41 patients were administered bilateral GON block while the other 41 patients GON + SON block. Nerve blocks were administered every 10 days for a total of 5 sessions. After each administration and 20 days after the last injection, information on pre and post treatment numerical rating scale (NRS) score, number of painful days, analgesic intake, …

A Comparison Of Mycophenolate Mofetil And Calcineurin Inhibitor As Maintenanceimmunosuppression For Kidney Transplant Recipients: A Meta-Analysis Of Randomizedcontrolled Trials, Jin Deng, Yi Lu, Lihong He, Jihong Ou, Hongping Xie

Turkish Journal of Medical Sciences

Background/aim: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the comparison and its timing between mycophenolate mofetil (MMF) and calcineurin inhibitor (CNI) as maintenance immunosuppression for kidney transplant recipients. Materials and methods: The RCTs of MMF versus CNI as maintenance immunosuppression for kidney transplant recipients were searched from PubMed, Embase, Cochrane Central Register of Controlled Trials (CCRCT), and ClinicalTrials.gov. After screening relevant RCTs, two authors independently assessed the quality of included studies and performed a meta-analysis using RevMan5.3. Relative risk (RR) was used to report dichotomous data, while mean difference (MD) with 95% confidence …

Clinical And Molecular Findings In 37 Turkish Patients With Isolated Methylmalonic Acidemia, Berna Şeker Yilmaz, Deni̇z Kör, Fatma Derya Bulut, Sebi̇le Kilavuz, Serdar Ceylaner, Hali̇se Nesli̇han Önenli̇ Mungan

Turkish Journal of Medical Sciences

Background/aim: Isolated methylmalonic acidemia (MMA) is caused by complete or partial deficiency of the enzyme methylmalonylCoA mutase (mut0 or mut- enzymatic subtype), a defect of its cofactor adenosyl-cobalamin (cblA, cblB, or cblD-MMA), or deficiency of the enzyme methylmalonyl-CoA epimerase. While onset of the disease ranges from the neonatal period to adulthood, most cases present with lethargy, vomiting and ketoacidosis in the early infancy. Major secondary complications are; growth failure, developmental delay, interstitial nephritis with progressive renal failure, basal ganglia injury and cardiomyopathy. We aimed to demonstrate clinical and molecular findings based on long-term follow up in our patient cohort. Materials …

Lack Of Awareness Of Hepatitis B Screening And Vaccination In High-Risk Groups, Hati̇ce Yasemi̇n Balaban, Abdullah Tarik Aslan, Şefi̇ka Nur Ayar, Osman Dağ, Alpaslan Alp, Cem Şi̇mşek, Cavanşi̇r Vahabov, Tolga Yildirim, Hakan Göker, Yahya Büyükaşik, Hali̇s Şi̇mşek

Turkish Journal of Medical Sciences

Background/aim: Hepatitis B virus (HBV) vaccination rates are insufficient in high-risk patients worldwide. This study aimed to investigate the screening, immunization, and vaccination rates in three high-risk groups for HBV infection: allogeneic hematopoietic stem cell transplantation (AHSCT), renal transplantation (RT), and chronic hepatitis C (CHC) groups. Materials and methods: The serological data of consecutive patients between 2014 and 2019 were reviewed using the hospital database. Results: The HBV screening rates were 100.0%, 90.4%, and 82.4% in the AHSCT, CHC, and RT groups, respectively (p = 0.003). The immunization rates against HBV through either previous exposure or vaccination were 79.5%, 71.7%, …

Pancreas And Kidney Changes In Type 2 Diabetes Patients: The Role Of Diffusion-Weightedimaging, Mehmet Hamdi̇ Şahan, Adnan Özdemi̇r, Neşe Asal, Mi̇race Yasemi̇n Karadeni̇z Bi̇lgi̇li̇, Adi̇l Doğan, Aşkin Güngüneş

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to compare renal and pancreatic apparent diffusion-coefficient (ADC) values of diabetic patients and control subjects and to examine their potential association with several diabetes-related clinical parameters. Materials and methods: A total of 80 sex- and age-matched patients were included in the study. Of them, 40 were patients with type 2 diabetes and 40 were nondiabetic participants. Abdominal diffusion-weighted MRIs of both groups were retrospectively reviewed. Diabetes-related clinical parameters were recorded. Results: The difference between the mean ADC values of the patient group and the control group was significant (p = 0.012). It was …

Does Previous Open Or Percutaneous Renal Stone Surgery Affect Retrograde Intrarenalsurgery Outcomes?, Özer Güzel, İbrahi̇m Can Aykanat, Yilmaz Aslan, Ahmet Asfuroğlu, Meli̇h Balci, Altuğ Tuncel

Turkish Journal of Medical Sciences

Background/aim: Open or percutaneous renal stone surgery can have an adverse effect on the collecting system of the kidney. We evaluated retrograde intrarenal surgery outcomes in patients with 󖼮 mm renal stones who had open or percutaneous renal stone surgery history. Materials and methods: A total of 707 patients who underwent retrograde intrarenal surgery treatment were included in this study. Fifty-six patients had open or percutaneous renal stone surgery history (Group 1) and the remaining did not (Group 2, n = 651). The groups were compared in terms of age, stone size, stone-free rates, and complications. Results: The mean age …

Effects Of Intraoperative Blood Loss During Liver Resection On Patients? Outcome: A Singlecenter Experience, Muhammed Seli̇m Bodur, Kadi̇r Tomas, Serdar Topaloğlu, Şükrü Oğuz, Hakan Küçükaslan, Davut Dohman, Erdem Karabulut, Adnan Çalik

Turkish Journal of Medical Sciences

Background/aim: Operative bleeding is one of the major determinants of outcome in liver surgery. This study aimed to describe the impact of intraoperative blood loss on the postoperative course of liver resection (LR). Materials and methods: The data of 257 patients who were treated with LR between January 2007 and October 2018 were retrospectively analyzed. LRs were performed via intermittent portal triad clamping (PTC) under low central venous pressure. Results: LRs were performed for 67.7% of patients with a malignant disease and 32.3% of patients with a benign disease. Major LR was performed in 89 patients (34.6%). The mean PTC …

The Effects Of Water Immersion And Epidural Analgesia On Cellular Immune Response,Neuroendocrine, And Oxidative Markers, Özlem Uzunlar, Ümi̇t Yasemi̇n Sert Di̇nç, Nezaket Kadioğlu, Tuba Çandar, Yaprak Üstün

Turkish Journal of Medical Sciences

Background/aim: Water immersion and epidural analgesia are the most preferred pain relief methods during the labor process. Adverse effects related to these methods, impact on the labor, and perception of pain is well studied in the literature. We aimed to investigate the cord blood level of copeptin, total serum oxidant (TOS), antioxidant (TAS), interleukin (IL)-1, IL-6, and oxytocin after the labor with water immersion, epidural analgesia, and vaginal birth without pain relief. Materials and methods: The study was conducted with 102 healthy pregnant women admitted to the obstetric delivery unit for noncomplicated term birth. Copeptin, oxytocin, TAS, TOS, IL-1, and …

Points To Consider When Evaluating Three-Dimensional Digital Subtraction Angiography Ofintracranial Aneurysms And Their Effects On Treatment, İsmai̇l Yardimcioğlu, Yilmaz Önal, Murat Veli̇oğlu, Hakki Muammer Karakaş

Turkish Journal of Medical Sciences

Background/aim: In this study, we aimed to investigate what should be regarded as potential determinants of treatment strategies when evaluating 3D digital subtraction angiography (DSA) images. Material and methods: Our inclusion criteria were as follows: (1) presence of at least one intracranial aneurysm demonstrated by conventional angiography, (2) having both 2D and 3D images, and (3) being over 18 years old. First, two-dimensional (2D) and then 3D angiography images of 226 aneurysms of 150 patients were scanned. Morphological characteristics such as size, configurations, relationship with parent artery, baby counts, and other incidental findings were determined. Results: Of the 226 aneurysms, …

Genistein Suppresses The Inflammation And Gsk-3 Pathway In An Animal Model Ofspontaneous Ovarian Cancer, Füsun Erten, Engi̇n Yeni̇ce, Cemal Orhan, Beşi̇r Er, Pinar Demi̇rel Öner, Patrick Brice Defo Deeh, Kazi̇m Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: Numerous studies show that cancer risk is reduced by consumption of soy-based foods containing genistein, but its effects on the glycogen synthase kinase-3 pathway (GSK-3) in ovarian cancer is unknown. Therefore, we tested the properties of genistein on inflammatory biomarkers and GSK-3 signaling pathways in the ovaries of old laying hens with ovarian cancer. Materials and methods: A total of 300 laying hens were distributed into three groups as follows: group 1, animals fed a standard diet (comprising 22.39 mg of genistein/kg of diet); groups 2 and 3, animals fed a standard diet reconstituted with supplementation of 400 mg …

Effect Of Betulinic Acid Administration On Tlr-9/Nf-Κb /Il-18 Levels In Experimentalliver Injury, Eda Dokumacioğlu, Hati̇ce İskender, Kübra Asena Teri̇m Kapaki̇n, Güler Yeni̇ce, Behzat Mokthare, İsmai̇l Bolat, Armağan Hayirli

Turkish Journal of Medical Sciences

Background/aim: Acetaminophen (APAP), used in the composition of thousands of preparations, is the most commonly used analgesic and antipyretic drug. The present study aimed to investigate the potential protective effects of the betulinic acid (BA) treatment through an APAP-induced hepatotoxicity rat model, using inflammatory, biochemical, and histopathological parameters. Materials and methods: The study consisted of four groups: control group, APAP group, BA group, and APAP+BA group. Experimental studies continued for fifteen days. Serum samples were analysed for glucose, total cholesterol (TChol), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), aspartate amino transferase (AST), malondialdehyde (MDA), toll-like receptor-9 (TLR-9), …