Medicine and Health Sciences Commons^™

Treatments For The Mitigation Of Immunotherapy-Related Neurotoxicities In Patients With Non-Small Cell Lung Cancer, Gautam Chiang

AUCTUS: The Journal of Undergraduate Research and Creative Scholarship

Lung cancer is the most common cancer type worldwide, with one of the highest mortality rates across all cancer types. Cancer immunotherapeutics such as immune checkpoint inhibitors (ICIs) have improved cancer treatment by promoting the body’s natural immune response to tumor development while avoiding toxic effects associated with traditional cytotoxic chemotherapy. However, immunotherapies have been associated with unique toxic effects similar to autoimmune disorders known as immune-related adverse events (irAEs). 4.2% of immunotherapy-treated cancer patients reportedly developed neurological irAEs. In this review, different immunotherapies were studied, including ICIs and mechanism-specific novel therapies, in order to determine a combination therapy to …

Examining Neuroanatomical Effects Of Prenatal Valproic Acid And Postnatal Testosterone In A Mouse Model Of Autism Spectrum Disorder, Bishakha Kumari, Elizabeth Ann Gordon, Cynthia Corbitt

Undergraduate Arts and Research Showcase

Sex differences in Autism Spectrum Disorder (ASD) are well documented; males are diagnosed 4:1 over females. Testosterone (T) is one factor that differs by sex in humans and mice that could increase vulnerability to developing ASD in males. Valproic acid (VPA) is an anticonvulsant that has been found to increase the risk of autism in male offspring of pregnant women who take it to control seizures and is commonly used in mouse models of ASD. After prenatal VPA or vehicle on embryonic day 13, testosterone (T) or vehicle was administered to the mice on postnatal day 2 to investigate whether …

The Inhibition Of Growth Of S. Cerevisiae, U. Maydis, And M. Lychinidis-Dioicae By Apiaecea Plant Extracts, Jackson M Hoffman, Jared Scott, David Schultz Phd

Undergraduate Arts and Research Showcase

The Apiaceae family of plants contains over 3,500 species, many of which are used as food crops: vegetables (carrot, parsnip, celery, etc.), herbs (cilantro, fennel, dill, etc.), and spices (cumin, anise, caraway, etc.). Many spices have been shown to exhibit antimicrobial properties against both bacteria and fungi. We set out to determine if the Apiaceae spice extracts currently used in our lab for anticancer studies exhibit any antimicrobial properties. Ethanolic extracts were made from several Apiaceae seeds: Apium graveolens (celery), Cuminum cyminum (cumin), Anethum graveolens(dill), Foeniculum vulgare (fennel), Coriandrum satvium (coriander), Pimpinella ansium (anise), Trachyspermum ammi (ajwain), Carum carvi …

The Association Between Social Capital And Depression, Abdulrahman Abudawood

CGU Theses & Dissertations

Mental health is an integral component of a healthy and balanced life, and deterioration in mental health has a significant impact on the quality of life. Being an active member of the community can positively impact personal mental health and emotional wellbeing. The World Health Organization (WHO) considers Social Capital (SC) a significant determinant of individual mental health. Despite that, there are limited studies analyzing the association between SC and the prevalence or severity of depressive symptoms experienced by suburban residents of the United States. This study aimed to assess the relationships between the six dimensions of SC introduced by …

Excision Of A Rare Triquetral Body Fracture Nonunion, Michael J. Niemann, William C. Brooks, Priscilla Cavanaugh, Andrea B. Lese, John S. Taras

Faculty & Staff Scholarship

Aside from the more common dorsal avulsion fractures, isolated triquetral body fractures are a rare injury and often missed. When they are identified, conservative treatment via immobilization is often the standard of care for initial treatment. Rarely, triquetral body fractures can develop into symptomatic nonunions, causing considerable pain and disability. Multiple classification schemes have been described to categorize triquetrum fractures; however, distal triquetrum fractures fit into none of the established models. There is scarce literature describing treatment of triquetral body fracture nonunions. The few reports that exist often use a variation of open reduction internal fixation with or without grafting …

Postdischarge Opioid Use After Total Hip And Total Knee Arthroplasty, Keenan Atwood, Taylor Shackleford, Wesley Lemons, Jennifer L. Eicher, Brock A. Lindsey, Adam E. Klein

Faculty & Staff Scholarship

Background

Methods

Meta-Analysis Comparing Direct Oral Anticoagulants Versus Vitamin K Antagonists In Patients With Left Ventricular Thrombus, Kazuhiko Kido, Yasir Abdul Ghaffar, James C. Lee, Christopher Bianco, Mikiko Shimizu, Tsuyoshi Shiga, Masayuki Hashiguchi

Faculty & Staff Scholarship

Current American College of Cardiology/American Heart Association guidelines for stroke or ST-elevation myocardial infarction recommend the use of oral vitamin K antagonists (VKAs) as a first-line anticoagulant. Although several studies have compared the use of direct oral anticoagulants (DOACs) to VKAs for left ventricular thrombus (LVT) anticoagula- tion therapy, they are small scale and have produced conflicting results. Thus, this meta- analysis was performed to aggregate these studies to better compare the efficacy and safety of DOACs with VKAs in patients with LVT. Cochrane Library, Google Scholar, MED- LINE, and Web of Science database searches through January 10, 2021 were …

Mir-212-3p Functions As A Tumor Suppressor Gene In Group 3 Medulloblastoma Via Targeting Nuclear Factor I/B (Nfib), Naveenkumar Perumal, Ranjana K. Kanchan, David Doss, Noah Bastola, Pranita Atri, Ramakanth C. Venkata, Ishwor Thapa, Raghupathy Vengoji, Shailendra K. Maurya, David Klinkebiel, Geoffrey A. Talmon, Mohd W. Nasser, Surinder K. Batra, Sidharth Mahapatra

Journal Articles: Biochemistry & Molecular Biology

Haploinsufficiency of chromosome 17p and c-Myc amplification distinguish group 3 medulloblastomas which are associated with early metastasis, rapid recurrence, and swift mortality. Tumor suppressor genes on this locus have not been adequately characterized. We elucidated the role of miR-212-3p in the pathophysiology of group 3 tumors. First, we learned that miR-212-3p undergoes epigenetic silencing by histone modifications in group 3 tumors. Restoring its expression reduced cancer cell proliferation, migration, colony formation, and wound healing in vitro and attenuated tumor burden and improved survival in vivo. MiR-212-3p also triggered c-Myc destabilization and degradation, leading to elevated apoptosis. We then isolated an …

Assessment Of Palliative Care Needs In A Kenyan Intensive Care Unit Based On A Trigger-Based Model., Linda Atero Barasa

Master of Medicine in Internal Medicine

Background: Palliative care triggers have been used in the Intensive Care Unit (ICU) setting, usually in high-income countries, to identify patients who may benefit from palliative care consults. The utility and benefits of palliative care triggers in the ICU have not been previously studied in sub-Saharan Africa. Objectives: The primary objective of this study was to estimate the prevalence of ICU admissions who meet the criteria for one or more palliative care triggers. The secondary objectives were to determine an association between palliative care consults and length of ICU stay, mortality, and time to formal change of goals of care …

Macomb Dental Society Journal Winter 2021

Journal of the Macomb Dental Society

In the Winter 2021 issue, the reader will find the following feature articles:

• Equity Incentive Plans in Dental Practice
• Dental Collaborations Helps Macomb County
• Renewing Your Lease: 5 Important Things to Know
• Life Threatening Emergencies in the Dental Office

Also included are regular columns from the President, Executive Director and Editor, as well as news shorts and information on upcoming events.

Identifying Participants With Knee Osteoarthritis Likely To Benefit From Physical Therapy Education And Exercise: A Hypothesis-Generating Study, So Tanaka, Tomohiko Nishigami, Benedict Martin Wand, Tasha R. Stanton, Akira Mibu, Masami Tokunaga, Takaaki Yoshimoto, Takahiro Ushida

Physiotherapy Papers and Journal Articles

Background: The purpose of this investigation was to undertake a hypothesis generating study to identify candidate variables that characterize people with knee osteoarthritis who are most likely to experience a positive response to exercise.

Methods: One hundred and fifty participants with knee osteoarthritis participated in this observational, longitudinal study. All participants received a standard exercise intervention that consisted of 20-min sessions two to three times a week for three months. The classification and regression tree methodology (CART) was used to develop prediction of positive clinical outcome. Positive pain and disability outcomes (dependent variables) were defined as an improvement in pain …

Implicit Motor Imagery Of The Foot And Hand In People With Achilles Tendinopathy: A Left Right Judgement Study, Ebonie K. Rio, Tasha Stanton, Benedict Wand, James Debenham, Jill Cook, Mark J. Catley, Lorimer Moseley, Prudence Butler, Kylie Cheng, Adrian Mallows, Monique V B Wilson, Michael Girdwood

Physiotherapy Papers and Journal Articles

Objective

To determine if impairment in motor imagery processes is present in Achilles tendinopathy (AT), as demonstrated by a reduced ability to quickly and accurately identify the laterality (left-right judgement) of a pictured limb. Additionally, this study aimed to use a novel data pooling approach to combine data collected at 3 different sites via meta-analytical techniques that allow exploration of heterogeneity.

Design

Multi-site case-control study.

Methods

Three independent studies with similar protocols were conducted by separate research groups. Each study-site evaluated left/right judgement performance for images of feet and hands using Recognise© software and compared performance between people with AT …

Implementing Skill Acquisition Research In High Performance Sport: Reflecting On The Importance Of Autonomy-Support For Successful Collaboration, Khaya Morris-Binelli, Sean Müller, Fleur E.C.A. Van Rens, Dave Staniforth, Brendyn Appleby, Simon M. Rosalie

Physiotherapy Papers and Journal Articles

Perceptual-cognitive-motor skills, such as visual anticipation, are pivotal for superior performance in sport. However, there are only a limited number of skill acquisition specialists working with coaches to develop these skills in athletes. The purpose of this paper is to present a brief reflection on the use of psychological strategies to create an autonomy-supportive environment to embed a skill acquisition research project in high-performance sport. The research project was conducted with the Australian national field hockey high-performance unit and investigated individual differences in expert goalkeepers’ visual anticipation. The paper first discusses the role of a skill acquisition specialist, how they …

Transitioning From Foster Care To Adulthood: Supporting Adolescents And Young Adults, The Rees-Jones Center For Foster Care Excellence

White Papers and Policy Briefs

Children involved in foster care have significant trauma histories and have often experienced substantial neglect and/or abuse. Such adverse childhood experiences can lead to cumulative toxic stress, which if not buffered by support and a consistent adult caregiver, can negatively impact physical, mental and socio-emotional development. Such experiences can also result in a lack of trust in adults and systems of care, which can further reduce sources of support for children in foster care.

For questions about this publication or others, please email [email protected]

childrens.com/fostercare

Sex Differences In Stress-Induced Sleep Deficits, Andrew T. Gargiulo, Varuna Jasodanand, Sandra Luz, Lauren O'Mara, Leszek Kubin, Richard J. Ross, Seema Bhatnagar, Laura A. Grafe

Psychology Faculty Research and Scholarship

Sleep disruptions are hallmarks in the pathophysiology of several stress-related disorders, including Major Depressive Disorder (MDD) and Post-Traumatic Stress Disorder (PTSD), both known to disproportionately affect female populations. Although previous studies have attempted to investigate disordered sleep in women, few studies have explored and compared how repeated stress affects sleep in both sexes in either human or animal models. We have previously shown that male rats exhibit behavioral and neuroendocrine habituation to 5 days of repeated restraint, whereas females do not; additional days of stress exposure are required to observe habituation in females. This study examined sex differences in sleep …

What Can We Learn From More Than 140,000 Moments Of Ecological Momentary Assessment-Assessed Negative Emotion And Ambulatory Blood Pressure? A Systematic Review And Meta-Analysis, Nataria T. Joseph, Elvina C. Chow, Laurel M. Peterson, Thomas W. Kamarck, Morgan Clinton, Madison Debruin

Psychology Faculty Research and Scholarship

Objective

Two decades of research has examined within-person associations between negative emotion states and ambulatory blood pressure (ABP) using ecological momentary assessment (EMA), but no meta-analysis has been conducted. We conducted this systematic review and meta-analysis to quantify the magnitude of this association and identify moderators, review strengths and weaknesses in conceptual and measurement approaches, and provide recommendations.

Methods

We searched databases (PsycINFO, PubMed), identified 15 studies, and obtained data from 13 studies (n = 2511; 142,307 observations).

Results

Random-effects meta-analyses demonstrated small effect r values between momentary negative emotions and systolic ABP (r = 0.06) and diastolic …

Stress, Coping, Resilience, And Sleep During The Covid-19 Pandemic: A Representative Survey Study Of Us Adults, Andrew T. Gargiulo, Laurel M. Peterson, Laura A. Grafe

Psychology Faculty Research and Scholarship

Introduction: The COVID-19 pandemic is a global health emergency resulting in widespread death and substantial disruption to daily life. Previous research has shown that novel disease outbreaks are associated with high stress levels and sleep impairments that lead to neuropsychiatric consequences. Therefore, it is vital to study both stress and protective factors such as coping and resilience that may hinder or help sleep quality during the COVID-19 pandemic. Further, as gender disparities exist in sleep quality, it is important to understand the relationship between pandemic-related stress, coping strategies, resilience, and sleep in bothgenders during the COVID-19 pandemic.

Methods: Our study …

Descriptive Norms And Prototypes Predict Covid-19 Prevention Cognitions And Behaviors In The United States: Applying The Prototype Willingness Model To Pandemic Mitigation, Laurel M. Peterson, Marie Helweg-Larsen, Sarah Dimuccio

Psychology Faculty Research and Scholarship

Background

Early in the COVID-19 pandemic, prevention behavior adoption occurred in a rapidly changing context. In contrast to expectancy-value theories, the Prototype Willingness Model (PWM) is well-suited for investigating novel and socially informed behaviors. Purpose

We explored whether PWM social cognitions predicted coronavirus prevention behaviors. Method

A representative sample of United States adults (N = 738; M_age = 46.8; 51.8% women; 78% white; April 2020) who had not had COVID-19 reported PWM predictor variables (perceived vulnerability, prevention descriptive norms, prototypes engaging in prevention behavior, and prevention behavioral intentions). Two weeks later, participants reported their prevention behaviors (handwashing, mask-wearing, social …

Effect Of Blood Flow Restriction Training On Functional And Self-Reported Outcomes In Female Runners With Patellofemoral Pain, Lauren Nicole Erickson

Theses and Dissertations--Rehabilitation Sciences

Background: Patellofemoral pain (PFP) is the leading cause of lower extremity injury in female runners, significantly limiting running ability and becoming chronic in nearly 50% of the cases. This condition, which presents as pain around (peripatellar) or behind (retropatellar) the patella, is associated with significant weakness of the quadriceps and gluteal musculature, as well as altered movements mechanics. The challenge for clinicians is designing an effective treatment program to reduce pain and improve function without causing symptoms to flare. Blood flow restriction training (BFRT) is a relatively new training method within rehabilitation that involves placing a pressurized cuff to the …

Impulsiveness, Depression, Sexual Behavior, And Sexually Transmitted Infections And Hiv-Related Outcomes Among Out-Of-School Adolescent Girls And Young Women In Rural Southern Malawi, Project Soar

HIV and AIDS

Under Project SOAR, the Population Council in collaboration with the University of Malawi College of Medicine monitored key HIV prevention, care, and treatment outcomes among populations who are targeted by the One-C program. Under that study, the Population Council investigated associations between impulsiveness, depression, sexual behavior, sexually transmitted infections, and HIV among out-of-school adolescent girls and young women. Impulsivity is a personality trait that has been associated with risky sexual behavior among young people in different settings in the developed world.

Overview: Literature Review Of Linkage, Adherence, And Retention Interventions For Seropositive Children And Young People In Africa, Project Soar

HIV and AIDS

Various strategies have been implemented in countries around the world to reduce barriers to engagement in care and adherence to antiretroviral therapy among children and young people living with HIV. Despite these diverse programmatic strategies, a comprehensive understanding of what works best for children and adolescents in sub-Saharan Africa is lacking. To address this gap, Project SOAR conducted a systematic review of the peer-reviewed literature to: 1) document interventions that support engagement in care and ART adherence for infants, children, adolescents, and youth living with HIV in sub-Saharan Africa (SSA), including orphans and other vulnerable children; and 2) inform future …

Factors Influencing Hiv Care Outcomes Among Adolescents Living With Hiv In Rural South Africa, Lindsey M. Filiatreau, Audrey Pettifor, Jess Edwards, Nkosinathi Masilela, Rhian Twine, F. Xavier Gómez-Olivé, Nicole Haberland, Chodziwadziwa Whiteson Kabudula, Sheri A. Lippman, Kathleen Kahn

HIV and AIDS

In the Agincourt Health and Socio-Demographic Surveillance System (HDSS) site in rural Mpumalanga Province, South Africa the Project SOAR team hypothesized that HIV status disclosure, individuals’ prior healthcare seeking experiences, history of depression and overall emotional well-being, experiences with domestic and intimate partner violence, and substance use could contribute to poor levels of treatment adherence among adolescents living with HIV. The overall objective of this study was to better understand HIV care outcomes among HIV-positive adolescents in the Agincourt HDSS in the era of universal test and treat so we can better inform HIV care programs targeting this vulnerable population.

The Power And Process Of Shifting Gender Norms: Insights From A Randomized Controlled Trial In South Africa, Nicole Haberland, Julie Pulerwitz, Ann Gottert, Audrey Pettifor, Sheri A. Lippman, Dean Peacock, Lumbwe Chola, Ryan Wagner, Anna M. Leddy, Rebecca West, Mi-Suk Kang Dufour, Jennifer Hove, Rhian Twine, Rhandzekile Mathebula, Dumisani Rebombo, Angelica Pino, F. Xavier Gómez-Olivé, Chodziwadziwa Whiteson Kabudula, Nkosinathi Masilela, Aimée Julien, Kathryn Spielman, Kathleen Kahn

HIV and AIDS

This Project SOAR report summarizes findings from a randomized controlled trial of Tsima ra rihanyu (“working together for health”), a three-year community mobilization program for treatment as prevention that aimed to address the social barriers to HIV testing and treatment in Mpumalanga Province, South Africa. In this report, the authors explore the types of gender norms that are salient for women and men, how these relate to HIV testing and treatment, and the pathways through which gender norms operate to affect women’s and men’s HIV service use and experience and perpetration of intimate partner violence.

Improving Pmtct Outcomes For Mother-Infant Pairs Through Community-Facility Linkage: Results From A Mixed Methods Study In Malawi, Michael Herce, Jess Edwards, Stephanie M. Topp, Michael Eliya, Nicole Carbone, Lauren Zalla, Jennifer Tseka, Maga Chagomerana, Mina C. Hosseinipour, Innocent Mofolo

HIV and AIDS

To improve MIP care retention in Malawi, several prevention of mother-to-child transmission of HIV (PMTCT) care delivery models have emerged to strengthen community-facility linkage (CFL), a concept defined as any “formalized connection between a health facility and the communities it serves to support improved health outcomes.” Similar to other settings in sub-Saharan Africa, three models have been widely implemented to complement Malawi’s National PMTCT Programme: 1) mentor mothers; 2) expert clients; and 3) community health workers. While the rationale underpinning these models has been substantiated by evidence generated from general antiretroviral therapy and PMTCT programs across SSA, a clear and …

Making Training Memorable: Assessing The Impact Of Animated Video On Learner Satisfaction, Engagement And Knowledge Retention, Leigh Highsmith

Doctor of Nursing Practice Projects

Media rich video provides attributes such as animation, narration, and music that can be incorporated into learning modules which have high potential to promote learning. This project evaluated the impact of transitioning a learning module from static PowerPoint slides to animated (media rich) video on employee satisfaction, engagement, and knowledge retention. Learner satisfaction and engagement was measured using a validated survey instrument designed to evaluate the effectiveness, appeal, and efficiency of the animated video about Hospice and Palliative Care. Knowledge retention was measured by comparing post-test scores between the initial and subsequent second post-test. A retrospective design was used to …

Addressing Hidden Barriers To Follow Up Healthcare: A Community Referral Pilot Project, Amber Williams

Doctor of Nursing Practice Projects

Objective: The project was aimed to reduce the number of participants lost to primary care follow-up following a mobile health unit screening event.

Design: A pilot study program screening tool implementation was utilized to address the hidden barriers of the Social Determinants of Health (SDoH) during a Winter 2021 event.

Sample: A group of 12 participants were screened during a mobile health unit event. Eight of the participants opted to be a part of the pilot study.

Measurements: A comparison ratio of Primary Care follow up was compared from the Winter of 2020 with Winter of 2021, where the screening …

Aerosol Spacers With Asthma Inhalers: Best Practice For School Health Nurses, Casey Page

Doctor of Nursing Practice Projects

Healthcare providers do not have adequate knowledge regarding the use of aerosol spacers and asthma inhalers. Inappropriate use of asthma inhalers may lead to poor medication distribution in the lungs and poor asthma control. The utilization of aerosol spacers with asthma inhalers is shown to increase medication distribution to the lungs. Asthma is the number one chronic condition seen by school health nurses. An online learning module was created for school health nurses to reiterate the best practice use of aerosol spacers with asthma inhalers. After completion of the online learning module, school health nurses answered nine questions on an …

Readiness To Change In Rural Adults At High Risk For Diabetes, Katherine A. Wagner

Dissertations and Theses

Type II diabetes is one of the most devastating chronic diseases in the United States and is associated with decreased lifespan and serious comorbidities. While evidence-based prevention strategies of nutrition and physical activity exist, behavior change is an essential component. Researchers use readiness to change to predict clinical outcomes of chronic disease prevention programs, however, this has not been well studied in rural populations. The purpose of this research was to study the relationship between readiness to change and attrition rates and clinical outcomes among rural dwellers enrolled in a nutrition and physical activity intervention. Article one of this three-article …

Cytopenias After Cd19 Chimeric Antigen Receptor T-Cells (Car-T) Therapy For Diffuse Large B-Cell Lymphomas Or Transformed Follicular Lymphoma: A Single Institution Experience., Andrew Schaefer, Ying Huang, Adam Kittai, Joseph E Maakaron, Caner Saygin, Jonathan Brammer, Sam Penza, Ayman Saad, Samantha M Jaglowski, Basem M William

Oncology Articles

INTRODUCTION: Patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) have poor outcomes. Treatment with CD19 chimeric antigen receptor (CAR-T) cells, tisagenlecleucel and axicabtagene ciloleucel, has been associated with improved outcomes. Cytopenias were observed in clinical trials with both products; however, little is known regarding the patterns and outcomes of these cytopenias.

SUBJECTS AND METHODS: We reviewed DLBCL patients (

RESULTS: Median duration of leukopenia, neutropenia, lymphopenia, anemia, and thrombocytopenia was 49, 9, 117.5, 125, and 95.5 days after CAR-T infusion, respectively. Filgrastim was used in 63% of patients, and 50% of patients received red cell or platelet transfusions. With the …

Psychological Distress And Affective, Behavioral And Cognitive Experiences Of Stuttering, Randy W. Panzarino

Electronic Theses and Dissertations, 2020-2023

Adults who stutter (AWS) are vulnerable to the development of various psychopathological symptoms, although prevalence data are mixed, and even less clarity exists as it relates to the factors that potentially influence their occurrence. The current study sought to shed light on the prevalence of self-reported psychopathology in AWS and aimed to identify relationships between affective, behavioral and cognitive (ABC) experiences of stuttering and psychological distress. This was based on AWS' reports of speech situation-specific anxiety and speech disruption, the use of behaviors to avoid or escape stuttering, and one's communication attitude. The self-reports administered to 40 AWS via Qualtrics, …