Medicine and Health Sciences Commons^™

Transient Receptor Potential Melastatin 2 Ion Channel Activity In Ovarianhyperstimulation Syndrome Physiopathology, Cengi̇z Şanli, Remzi̇ Atilgan, Tuncay Kuloğlu, Şehmus Pala, Bi̇lge Aydin Türk, Hasan Burak Keser, Nevi̇n İlhan

Turkish Journal of Medical Sciences

Background/aim: Ovarian hyperstimulation syndrome (OHSS) is a complication of ovarian stimulation with increased vascular endothelial growth factor (VEGF) and vascular permeability in the ovarian tissue. Transient receptor potential melastatin 2 (TRPM2) is known to be associated with angiogenesis and vascular permeability. In this experimental study, we aimed to investigate the activity of TRPM2 in the development of OHSS. Materials and methods: Fourteen immature female rats were divided into two groups. Group 1 was the control group, and Group 2 was the OHSS group that was exposed to 10 IU of subcutaneous application of FSH for four days and 30 IU …

Vitamin D Receptor Polymorphisms And Bone Health After Kidney Transplantation, Berfu Korucu, Fatma Ajlan Tükün, Özant Helvaci, Haci Hasan Yeter, Sevi̇m Gönen, Gali̇p Güz, Seli̇m Turgay Arinsoy

Turkish Journal of Medical Sciences

Background/aim: Bone disease is one of the most prominent complications after kidney transplantation. Bone diseases include osteoporosis, persistent secondary hyperparathyroidism, and avascular necrosis (AVN). We investigated the relationship between the polymorphisms of the vitamin D receptor (VDR) gene and bone diseases occurring after kidney transplantation. Materials and methods: The study consists of 234 kidney allograft recipients with a minimum follow-up of five years after kidney transplantation. Patients with glomerular filtration rates less than 30 mL/min/1.73m2 , a history of parathyroidectomy, bisphosphonate use pre- or post-transplantation, and cinacalcet use posttransplantation excluded. We evaluated associations between the polymorphisms of the VDR gene …

Reliability And Validity Of The Turkish Version Of The Vestibular Rehabilitation Benefitquestionnaire, Bülent Gündüz, Yasemi̇n Apaydin, Arzu Güçlü Gündüz, Burak Kabi̇ş, Hakan Tutar

Turkish Journal of Medical Sciences

Background/aims: Vestibular rehabilitation has an important role in the reduction of symptoms and in the recovery of patients in peripheral vestibular pathologies. Objective and subjective vestibular assessment tools are needed to assess vestibular rehabilitation effectiveness. The aims of the study were to develop the Turkish version of the internationally used Vestibular Rehabilitation Benefit Questionnaire (VRBQ) measure and to demonstrate the reliability and validity properties of the Turkish version in patients with peripheral vestibular hypofunction (PVH). Materials and methods: 110 patients with unilateral PVH were included. For the analysis of test-retest reliability, Turkish version of VRBQ developed by translation-back translation method …

Evaluation Of Serum Cxc Chemokine Ligand 16 (Cxcl16) As A Novel Inflammatory Biomarker Or Familial Mediterranean Fever Disease, Taner Akyol, Tolga Düzenli̇, Alpaslan Tanoğlu

Turkish Journal of Medical Sciences

Background/aim: Familial Mediterranean fever (FMF) is a disease that is mainly diagnosed with clinical features. Several wellknown inflammatory markers increase in FMF. However, there is still a need for diagnostic tests for specifying FMF and monitoring inflammatory activity. CXCL16 is a chemokine produced by inflammatory cells that demonstrate efficacy in the acute phase response. In this study, we aimed to investigate the relationship between CXCL16 levels and FMF disease and to evaluate CXCL16 levels as a novel biomarker for FMF. Materials and methods: Fifty-three male patients diagnosed with FMF and sixty healthy individuals were included in this crosssectional study. Blood …

Metformin Promotes Apoptosis In Primary Breast Cancer Cells By Downregulation Ofcyclin D1 And Upregulation Of P53 Through An Ampk-Alpha Independent Mechanism, Güven Yenmi̇ş, Nai̇l Beşli̇, Eli̇f Yaprak Saraç, Fatma Si̇nem Hocaoğlu Emre, Kazim Şenol, Gönül Kanigür

Turkish Journal of Medical Sciences

Background/aim: In the present study we aimed to figure out the effect of metformin on the expression of AMPK-alpha, cyclin D1, and Tp53, and apoptosis in primary breast cancer cells (PBCCs). Materials and methods: PBCCs were treated with two doses of metformin (0 mM, 25 mM). Proliferation was determined by BrdU assay. Real-time PCR was used to assess AMPK-alpha, cyclin D1, and Tp53 gene expressions; apoptotic indexes of PBCCs were analyzed using flow-cytometry. Results: Twenty-four-hour incubation with 25 mM metformin reduced the proliferation of PBCCs. AMPK-alpha gene expression in PBCCs was not affected by 25 mM metformin treatment compared with …

Inflammatory Complications Of Vocal Fold Injection With Hyaluronic Acid: Amultiinstitutional Study, Necati̇ Enver, Elad Azi̇zli̇, Sevtap Akbulut, Emel Çadalli Tatar, Muhammed Kürşad Yelken, Kayhan Öztürk, Hakan Coşkun, Ahmet Hakan Bi̇rkent, Zahi̇de Çi̇ler Büyükatalay, Ozan Bağiş Özgürsoy, Haldun Oğuz

Turkish Journal of Medical Sciences

Background/aim: This study aimed to assess the inflammatory adverse reactions of vocal fold injection laryngoplasty with hyaluronic acid. Materials and methods: This study was a retrospective chart review of patients who underwent vocal fold injection augmentation with HA injection from January 2005 to September 2016 in nine different institutions. Demographic data, indication for injection, injection techniques, types of injection material, settings of procedure, and complications were reviewed. The types of complication, onset time, and management of complications were also noted. Results: In all, 467 patients were identified. The majority of patients had been injected under general anesthesia (n = 382, …

Nonsteroidal Antiinflammatory Drugs Alter Antibiotic Susceptibility And Expression Ofvirulence-Related Genes And Protein A Of Staphylococcus Aureus, İsmai̇l Öztürk, Yasemi̇n Eraç, Petek Ballar Kirmizibayrak, Şafak Ermertcan

Turkish Journal of Medical Sciences

Background/aim: Nonsteroidal antiinflammatory drugs (NSAIDs) including diclofenac, naproxen, ibuprofen, acetylsalicylic acid, and acetaminophen have been shown to have antimicrobial effects on various microorganisms. The aim of this study was to investigate the antibacterial effects of NSAIDs on Staphylococcus aureus. Materials and methods: Susceptibilities of S. aureus strains to NSAIDs with or without antimicrobials (moxifloxacin, vancomycin, ciprofloxacin, clindamycin, and gentamicin) were determined using the microdilution method and disk diffusion test. Expression levels of genes in the presence of drugs were investigated by real-time quantitative RT-PCR (qRT-PCR), and immunoblotting analysis was performed for staphylococcal protein A (SpA). Results: Our results showed that …

The Effect Of Caffeic Acid Phenethyl Ester And Ankaferd Blood Stopper On The Diabetic Andnondiabetic Gingival Wound Healing: An Experimental Study, Mehmet Gül, Serkan Dündar, Gökhan Artaş, Akin Yi̇ği̇n, Abdulsamet Tanik, Mehmet Emrah Polat, Erhan Cahi̇t Özcan

Turkish Journal of Medical Sciences

Background/aim: Healthy wound healing is very important for patient comfort. Diabetes is one of the factors that negatively affect wound healing. Ankaferd Blood Stopper (ABS) and caffeic acid phenethyl ester (CAPE) are antiinflammatory and antimicrobial agents and may have positive effects on wound healing. Materials and methods: In this study, 72 male Wistar albino rats were used. Rats; control, CAPE, ABS, diabetes + control, diabetes + ABS and diabetes + CAPE groups were divided into 6 groups. A healthy 36 rats created diabetes using streptozotocin (STZ). A gingival wound was created using a 4-mm punch biopsy in the gingival tissue …

Effects Of Sitagliptin On Ss-Adrenoceptor Mediated Relaxation In Streptozotocin-Diabeticrat Aorta, Ayhanim Eli̇f Müderri̇soğlu, Betül Rabi̇a Erdoğan, Zeynep Eli̇f Yeşi̇lyurt, Ceren Uyar Boztaş, İrem Karaömerli̇oğlu, Vecdi̇ Meli̇h Altan, Ebru Arioğlu İnan

Turkish Journal of Medical Sciences

Background/aim: Dipeptidyl peptidase-4 (DPP4) inhibitors, a class of oral antidiabetic drugs, have been shown to be protective on the vascular system because of their antiinflammatory, antiatherosclerotic, and vasodilatory effects. ß2 -adrenoceptors (ß2 -ARs) mediate the vasorelaxation in the aorta. However, ß3 -adrenoceptor-mediated relaxation has not been studied in diabetic aorta yet. Thus, we aimed to study the effect of sitagliptin treatment on ß2 - and ß3 -adrenoceptor-mediated relaxations in the diabetic rat aorta. Materials and methods: Eight-week old Sprague Dawley rats were divided into three groups: control, diabetic, sitagliptin treated diabetic. Diabetes was induced by injection of streptozotocin (35 or …

Cutaneous Adnexal Tumors: The Diagnostic Role Of Dermatoscopic Examination, Ömer Faruk Elmas, Abdullah Demi̇rbaş, Ülker Gül, Mustafa Atasoy

Turkish Journal of Medical Sciences

No abstract provided.

Covid-19 Transmission Sources, Management, And Scientific Research In Turkey, Fati̇h Kahraman, Adem Özkara

Turkish Journal of Medical Sciences

No abstract provided.

Using Dialogic Reading To Facilitate Intergenerational Interactions In Persons With Aphasia: A Feasibility Study, Gillian I. Anderson

Honors Undergraduate Theses

The purpose of this study was to evaluate the effectiveness of teaching dialogic reading (DR) strategies to patients with aphasia (PWA) as measured by DR strategy use during virtual training sessions. The secondary purpose was to improve psychosocial factors, including communicative participation, perceived stress, and confidence. A single subject multiple baseline across behaviors research design was employed via a telehealth model to examine a training program in DR strategies on expressive linguistic abilities and aspects of quality of life (QoL) in a PWA. Treatment was given four to five times a week and the session length varied based on the …

Association Of Physical Activity On Memory Interference: Boston Puerto Rican Health Study, Paul D. Loprinzi, Lindsay K. Crawford, Tammy Scott, Katherine L. Tucker

Faculty and Student Publications

Background: The objective of this study was to evaluate the association between habitual physical activity engagement on memory interference. The present analysis used cross-sectional data from the Boston Puerto Rican Health Study (n=1,241; mean age= 57.2; 72.1% female). Methods: Physical activity was evaluated via self-report. Memory interference was evaluated using a word-list paradigm. The memory task included learning a list of 16 words (List A; 5 trials), followed by a distractor list (List B), and then an immediate recall of List A. Proactive interference occurs when preceding stimuli (e.g., Trial 1 and Trial 5 of List A) interferes with performance …

Evaluation Of Benefits Associated With Chemotherapy Dose-Banding Practices, Alexis Mann Pharmd, Mba, Kyle Becker Pharmd, Mba, Bcop, Jesse Christman Pharmd, Bcop

Parkview Pharmacy Department

2021 ASHP Midyear Clinical Meeting / Virtual Meeting / Poster # 1130014

The objective of this study was to evaluate the benefit of applying a 10% rounding strategy with predetermined dose-bands to the current chemotherapy dosing policy at Parkview Health.

College Of Optometry 2021, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Occupation-Based Intervention With Evaluation Of The Home Environment For Older Adults In A Long-Term Care Facility, Teo Faulkner, Autumn Hopkin, Anna Logan

Critically Appraised Topics

The purpose of this critically appraised topic (CAT) is to recommend education of longterm care staff on the residents and the residents’ previous experiences and preferred occupations and how home evaluation within the long-term care facility with recommendations for the environment could indicate where there is occupational deprivation, and lack of occupational based/client-centered interventions for adults 65 and older in long-term care facilities.

Post-Breast Cancer Related Lymphedema Interventions And Their Relationship To Social Involvement And Quality Of Life For Middle-Aged Women, Abby Bauman, Jenna Holm, Sarah Zuelzke

Critically Appraised Topics

In the United States, statistics have shown that there is a one in eight percent chance that a woman will develop breast cancer sometime throughout their life, and it is estimated that there will be 281,550 new cases of invasive breast cancer diagnosed in women in the year 2021 (American Cancer Society, 2021). One in five of the women who survive breast cancer will develop lymphedema within the initial three years following their breast cancer treatment (American College of Surgeons, 2013; DiSipio et al., 2013). Lymphedema is a chronic and progressive condition that is defined by the abnormal swelling caused …

Comparison Of Maxillary Expansion Between Clear Aligners And Removable Expansion Appliance In The Mixed Dentition, Micaela Zaverdinos, Paul Kasrovi, James Chen, Heesoo Oh

Orthodontics and Endodontics Theses

Introduction: Orthodontic and orthopedic expansion is necessary to create space to resolve crowding due to arch deficiency or tooth size discrepancy. The Invisalign First clear aligner appliance as a modality for early interceptive orthodontic treatment has become incorporated into orthodontic practices in very recent years. The present study aims to investigate the magnitude of expansion of the Invisalign First clear aligner appliance compared to a Schwartz removable expander in patients with mixed dentition. Additionally, the study aims to compare the efficacy and predictability of Invisalign First clear aligners in this population. Materials & Methods: In this retrospective study, a sample …

Predictors And Risk-Adjusted Outcomes Of New-Onset Postoperative Atrial Fibrillation In Surgical And Transcatheter Aortic Valve Replacement [Post-Af Ravr Protcol], Julia Dokko, Samantha Novotny, Xiaoyue Zhang, Sohaib Agha, Ashutosh Yaligar, Natalie Kolba, Vineet Tummala, Puja Parikh, Aurora Pryor, Henry Tannous, A. Laurie Shroyer, Thomas Bilfinger

Department of Surgery Faculty Publications

No abstract provided.

Language Abilities Of Children Who Qualify For Both Speech Therapy And Play Therapy, Rylee Atkins

2021 Honors Symposium

• Interprofessional collaboration in the educational setting is vital to a holistic approach to addressing a child’s individual needs. Despite the benefits of interprofessional practices (IPP), collaboration in the educational setting can be challenging. Some challenges that impede IPP from occurring in the school setting include time constraints and awareness of roles; however, interprofessional practice can be an effective way to set a child up for success (Kerins, 2018). There is substantial evidence that supports the idea of collaboration within services for the well-being of the child (Choi & Pak, 2006; Ellis et al., 2005; Johnson, 2016). Counselors and speech-language …

Bimodal And Bilingual: Language Characteristics Of Asl And English Users In Deaf Education, Caitlin Bumpass

2021 Honors Symposium

Background:
• Understanding how language develops in children who are learning two languages can provide a better understanding of language development in general.
• There is an abundant amount of research regarding language skills of children who are deaf or hard of hearing (d/hh); however, it is unclear if researchers are using a similar definition when describing the characteristics of bimodal/bilingualism.
• Bimodal bilingualism is the use of both an oral language and a sign language, which in the U.S. often includes the ability to perceive and produce both American Sign Language (ASL) and spoken and/or written English.

Purpose:
• …

The Diffusion Of Augmentative And Alternative Communication: A Qualitative Application Of Everett Rogers’S Theory Of Diffusion To Aac Refusal And Abandonment Literature, Foster Ellis

2021 Honors Symposium

INTRODUCTION
• Empirical evidence demonstrates benefits of AAC communication for individuals with intellectual and developmental disabilities
• However, trends of refusal and abandonment of AAC systems by these populations have been documented
• Diffusion of Innovations by Everett Rogers introduces a framework conceptualizing why some innovations encounter uptake while others suffer abandonment or refusal
• The framework includes four factors that are cited as contributing to uptake: the innovation, communication channels, time, and the social system
• This study examines the characteristics important to the innovation factor in order to provide data specific to the innovation of AAC systems
• …

Analysis Of Social Skills In Children With Autism And Asperger’S Through Child And Parent Responses To Ssis And Brief-Sr T Testing, Kailey Fender

2021 Honors Symposium

This study provides an in-depth analysis of the results from the Social Skills Improvement System (SSIS) and Behavior Rating Inventory of Executive Function - Self Report Version (BRIEF-SR T) tests taken by twenty-eight children and their parents through self-reporting the children's social behaviors.

A Replication Study Of Occupational Therapists’ Use And Opinions Of Apps In Therapy For The State Of Arkansas, Paige Francis

2021 Honors Symposium

BACKGROUND
• mHealth applications are increasingly utilized within healthcare practice (Baig et al., 2015).
• It is imperative that app development targets needs within occupational therapy

PURPOSE
• To recognize what aspects of apps Arkansan occupational therapists use and what they hope to see improve, to inform future app development.

Aac Intervention In Low- And Middle-Income Countries: The Experts’ Perspective, Elizabeth Fulton

2021 Honors Symposium

INTRODUCTION
• There is a lack of research on augmentative and alternative communication in low- and middle income (LAMI) countries. Without research, people in LAMI countries with intellectual and developmental disabilities (IDD) are left without effective services.
• Currently, there are high levels of disparities in speech intervention for individuals with IDD in LAMI countries.

RESEARCH QUESTIONS
• What do you see as the most pressing disparities limiting communication outcomes for individuals with IDD who require AAC in LAMI countries?
• What do you see as the largest barriers precluding LAMI countries from addressing those disparities?
• What do you …

The Effect Of Screen Time/Technology On Children With Hearing Loss, Alexa Goodwin

2021 Honors Symposium

Introduction
The use of technology is often promoted as an impactful educational tool, but research often fails to link to these positive outcomes. Negative impacts of “screen addiction” on children whose brains are still developing is an oftenexpressed concern. This is due to excessive screen exposure correlating with increases in disorders such as depression, ADHD, anxiety, and aggression. However, some consider technology use to be valuable for social skills and connection. This study explores the correlation of screen exposure on the executive functioning and social skills of children with hearing loss between the ages 8-12. Executive functioning includes mental skills …

Prevailing Theories Of Over-Imitation, Christa Griffith

2021 Honors Symposium

Imitation is a naturally occurring process of human development where individuals can learn different skills and behaviors by mimicking those around them. Imitation plays a vital role in the development of cognitive and social communication behaviors such as language and joint attention. Although imitation appears to have a clear positive utilization there are instances where its utility is reduced. Over-imitation is the process of an individual imitating actions even when those actions are not causally relevant to the objective to the task. Whiten et al. (2016) said that “the occurrence of overimitation in the real world, maximizes the power of …

How Music Shapes Our Identities And Why It Matters: Case Studies Of Professional Musicians, Annabelle Linker

2021 Honors Symposium

Brain research has demonstrated that music uniquely contributes to neural functioning, but little is known about how losing the ability to produce music, which may be inherent to personal identity for professional singers,impacts quality of life. The results of this study may provide insight for enhancing the use of music as a therapeutic tool that bridges identity and quality of life. Findings are discussed in relation to claims that awareness of personal identity in speech-language interventions can contribute to patient centered discussions about quality of life. Thisstudy explored identity and music in the lives of five well-known vocal music professionals …

The Effects Of Chemotherapeutic Agents On Cognitive Function: A Literature Review, Corinne Menz

2021 Honors Symposium

Chemotherapy is commonly the first-line treatment for various types of cancers. However, adverse effects resulting from treatment can negatively impact the patient’s quality of life while receiving chemotherapy as well as once the therapy course has been completed. The most commonly experienced effect is chemotherapy related cognitive impairment (CRCI) and is often referred to as “chemobrain”. This review attempts to explore the potential causes of cognitive decline, effects of chemotherapy treatment, and subjective patient reports. Relevant research was compiled in order to understand CRCI and its implications for the care of cancer patients.

Noise Exposure And Hearing Protection In Marching Band Students, Emily Myers

2021 Honors Symposium

Musicians, marching band students in particular, are at risk for Noise Induced Hearing Loss (NlHL) as they are frequently exposed to sound levels ranging from 85-114dB (Dinakaran, & Rejoythadathil, 20 I 8; Jansen et al., 2008; Libbin, 2008). It is recolillilended that those exposed to loud sounds wear ear protection regularly (Audiological Services for Musicians and Music Industry Personell, 2019.; Loud Noise Dangers, n.d.). Musicians are often reluctant to wear hearing protection for various reasons (Jin et al., 2013). Standard earplugs are typically offered to marching band members.

The purpose of this study was to determine how many band members …