Medicine and Health Sciences Commons^™

Modeling The Effect Of Lockdown Timing As A Covid‑19 Control Measure In Countries With Differing Social Contacts, Tamer Oraby, Michael G. Tyshenko, Jose Campo Maldonado, Kristina Vatcheva, Susie Elsaadany, Walid Q. Alali, Joseph C. Longenecker, Mustafa Al‑Zoughool

School of Mathematical & Statistical Sciences Faculty Publications

The application, timing, and duration of lockdown strategies during a pandemic remain poorly quantified with regards to expected public health outcomes. Previous projection models have reached conflicting conclusions about the effect of complete lockdowns on COVID-19 outcomes. We developed a stochastic continuous-time Markov chain (CTMC) model with eight states including the environment (SEAMHQRD-V), and derived a formula for the basic reproduction number, R0, for that model. Applying the R 0 formula as a function in previously-published social contact matrices from 152 countries, we produced the distribution and four categories of possible R 0 for the 152 countries and chose one …

Endovascular Thrombectomy Time Metrics In The Era Of Covid-19: Observations From The Society Of Vascular And Interventional Neurology Multicenter Collaboration, Alexandra L. Czap, Alicia M. Zha, Jacob Sebaugh, Ameer E. Hassan

School of Medicine Publications

Background Unprecedented workflow shifts during the coronavirus disease 2019 (COVID-19) pandemic have contributed to delays in acute care delivery, but whether it adversely affected endovascular thrombectomy metrics in acute large vessel occlusion (LVO) is unknown.

Methods We performed a retrospective review of observational data from 14 comprehensive stroke centers in nine US states with acute LVO. EVT metrics were compared between March to July 2019 against March to July 2020 (primary analysis), and between statespecific pre-peak and peak COVID-19 months (secondary analysis), with multivariable adjustment.

Results Of the 1364 patients included in the primary analysis (51% female, median NIHSS 14 …

A Concise Review Of The Multimodality Imaging Features Of Renal Cell Carcinoma, Ali Morshid, Elif S. Duran, Woongsoon J. Choi, Cihan Duran

School of Medicine Publications

The evaluation of renal cell carcinoma (RCC) is routinely performed using the multimodality imaging approach, including ultrasonography, computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET). Ultrasonography is the most frequently used imaging modality for the initial diagnosis of renal masses. The modality of choice for the characterization of the renal mass is multiphasic CT. Recent advances in CT technology have led to its widespread use as a powerful tool for preoperative planning, reducing the need for catheter angiography for the evaluation of vascular invasion. CT is also the standard imaging modality for staging and follow-up. MRI …

Mind-Body Interventions To Reduce Coronavirus Pandemic Stress And Support Long-Term Recovery, Patricia L. Gerbarg, Richard P. Brown

NYMC Faculty Publications

The COVID-19 pandemic is causing global stress, trauma and mental illness that has already outpaced current healthcare resources. Inequalities in the burden of illness, death, and economic loss are exacerbated by inequalities in the provision of mental health care. Minority populations and indigenous peoples bear the brunt of both inequities. Ancient healing systems, such as Yoga, Qigong, and tribal practices, are a rich source of group healing methods that can be studied and optimized for prevention and recovery during current and future disasters. Modern research is shedding light on a myriad of mechanisms that underly the healing properties of voluntarily …

Common Questions And Misconceptions About Creatine Supplementation: What Does The Scientific Evidence Really Show?, Jose Antonio, Darren G Candow, Scott C Forbes, Bruno Gualano, Andrew R Jagim, Richard B Kreider, Eric S Rawson, Abbie E Smith-Ryan, Trisha A Vandusseldorp, Darryn S Willoughby, Tim N Ziegenfuss

Faculty, Staff and Students Publications

Supplementing with creatine is very popular amongst athletes and exercising individuals for improving muscle mass, performance and recovery. Accumulating evidence also suggests that creatine supplementation produces a variety of beneficial effects in older and patient populations. Furthermore, evidence-based research shows that creatine supplementation is relatively well tolerated, especially at recommended dosages (i.e. 3-5 g/day or 0.1 g/kg of body mass/day). Although there are over 500 peer-refereed publications involving creatine supplementation, it is somewhat surprising that questions regarding the efficacy and safety of creatine still remain. These include, but are not limited to: 1. Does creatine lead to water retention? 2. …

Hermansky-Pudlak Syndrome-2 Alters Mitochondrial Homeostasis In The Alveolar Epithelium Of The Lung, Karina Cuevas-Mora, Willy Roque, Hoora Shaghaghi, Bernadette R Gochuico, Ivan O Rosas, Ross Summer, Freddy Romero

Faculty, Staff and Students Publications

BACKGROUND: Mitochondrial dysfunction has emerged as an important player in the pathogenesis of idiopathic pulmonary fibrosis (IPF), a common cause of idiopathic interstitial lung disease in adults. Hermansky-Pudlak syndrome (HPS) is a rare autosomal recessive disorder that causes a similar type of pulmonary fibrosis in younger adults, although the role of mitochondrial dysfunction in this condition is not understood.

METHODS: We performed a detailed characterization of mitochondrial structure and function in lung tissues and alveolar epithelial cells deficient in the adaptor protein complex 3 beta 1 (Ap3b1) subunit, the gene responsible for causing subtype 2 of HPS (HPS-2).

RESULTS: We …

Cited At Nuremberg: The American Eugenics Movement, Its Influence Abroad, The Buck V. Bell Decision, And The Subsequent Bioethical Implications Of The Holocaust, Bessie Blackburn

Bound Away: The Liberty Journal of History

Eugenics was a bioethical movement that captivated many Americans at the turn of the nineteenth century and even into the Progressive era. No event in American history better encapsulates the American eugenics movement than the trial of Carrie Buck and her later forced sterilization. This trial is monumental not only to understanding American eugenic policy, but also international reactions and Nazi Germany’s chilling use of this pseudoscience in the Holocaust. In order to best understand the trial of Carrie Buck, one must look first look at the origins of eugenics, second, the context of the eugenics movement in America and …

2021-02-07_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Taylor University's Isolation Experience: Life In The Dome, Logan Lockhart

Reflections, Poetry, Photos, and other Writings

This is a first-hand account of my experience in the dome during my isolation period, detailing the physical structure, happenings, the atmosphere, and my own reflection. I thought that there were historically significant happenings that needed to be recorded for posterity to better understand this interesting time in Taylor's history.

Super Bowl Precautions, February 7, 2021, University Of Northern Iowa

UNI Response to COVID-19

A reminder that safety precautions should be followed during Super Bowl weekend and that testing is available on campus.

Managing Vibration Training Safety By Using Knee Flexion Angle And Rating Perceived Exertion, Long-Ren Chuang, Wen-Wen Yang, Po-Ling Chang, Vincent Chiun-Fan Chen, Chiang Liu, Tzyy-Yuang Shiang

Engineering Science Faculty Publications

Whole-body vibration (WBV) is commonly applied in exercise and rehabilitation and its safety issues have been a major concern. Vibration measured using accelerometers can be used to further analyze the vibration transmissibility. Optimal bending angles and rating of perceived exertion (RPE) evaluations have not been sufficiently explored to mitigate the adverse effect. Therefore, the aims of this study were to investigate the effect of various knee flexion angles on the transmissibility to the head and knee, the RPE during WBV exposure, and the link between the transmissibility to the head and the RPE. Sixteen participants randomly performed static squats with …

Application Of Standardized Antimicrobial Administration Ratio As A Motivational Tool Within A Multi-Hospital Healthcare System, Stephanie Shealy, Joseph Kohn, Emily Yongue, Casey Troficanto, P Brandon Bookstaver, Julie Ann Justo, Hana R. Winders, Sangita Dash, Majdi N. Al-Hasan

Faculty Publications

The standardized antimicrobial administration ratio (SAAR) is a novel antimicrobial stewardship metric that compares actual to expected antimicrobial use (AU). This prospective cohort study examines the utility of SAAR reporting and inter-facility comparisons as a motivational tool to improve overall and broad-spectrum AU within a three-hospital healthcare system. Transparent inter-facility comparisons were deployed during system-wide antimicrobial stewardship meetings beginning in October 2017. Stakeholders were advised to interpret the results to foster competition and incorporate SAAR data into focused antimicrobial stewardship interventions. Student's -test was used to compare mean SAARs in the pre- (July 2017 through October 2017) and post-intervention periods …

Utilization Of A Statin Therapy Initiation Clinical Decision Aid In A Rural Health Clinic: Analysis And Implementation, Debra Schulte

Doctor of Nursing Practice Projects

Low-density lipoprotein (LDL) elevation is a primary risk factor for atherosclerotic cardiovascular problems such as heart disease and stroke. Heart disease is the leading cause of death in the United States and stroke is the fifth leading. Earlier LDL reduction improves morbidity and mortality. Literature indicates fewer women start statin medications compared to men. The purpose of this quality improvement project was to implement a policy change that integrated evidence-based clinical practice guidelines translated into a clinical decision tool. Our aim is to determine whether it would improve statin initiation for the local female population between the ages of 25 …

Intermittent Catheter Reimbursement In The United States: The Experience Of Nine Stakeholders Through The Lens Of Actor-Network Theory, Manon M. Schladen, Amanda K. Rounds, Terrence Mcmanus, Alexandra Bennewith, Henry Claypool, Suzanne L. Groah

The Qualitative Report

A narrow interpretation of “medical necessity” can result in poorer health as well as a more restricted life for people with disabilities. We examined the impact of US policy on reimbursement of intermittent catheters (ICs) on the lives of people with neurogenic bladder (NB) who require catheters to urinate. We conducted in-depth, longitudinal interviews with nine stakeholders. Actor-Network Theory was used to describe interactions among human agents, IC products, and policies in the reimbursement arena. Restrictions on the type and quantities of ICs reimbursed emerged as the most potent inhibitor to health and wellbeing among consumers with NB. IC suppliers, …

Sickle Haemoglobin: How Critical Are Laboratory Quality Measures For Accurate Identification?, Nazish Sana, Muhammad Shariq Shaikh

Department of Pathology and Laboratory Medicine

No abstract provided.

Use Of Ecomaps In Qualitative Health Research, Veena Manja, Ananya Nrusimha, Harriet Macmillan, Lisa Schwartz Dr, Susan Jack

The Qualitative Report

Qualitative health research plays a central role in exploring individuals’ experiences and perceptions of wellness, illness, and healthcare services. Visual tools are increasingly used for data elicitation. An ecomap is a visual tool that applies ecosystems theory to human communities and relationships to provide an illustration of the quality of relationships. We describe the use of ecomaps in qualitative health research. Searches across eight databases identified 407 citations. We screened them in duplicate to identify 129 publications that underwent full text review and included 73 in the final synthesis. We classified and summarized data based on iterative comparisons across sources. …

2021-02-06_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2021-02-06_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Monday - Saturday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …

2021-02-06_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Docosanoid Signaling Modulates Corneal Nerve Regeneration: Effect On Tear Secretion, Wound Healing, And Neuropathic Pain, Thang L. Pham, Haydee E P Bazan

School of Medicine Faculty Publications

The cornea is densely innervated, mainly by sensory nerves of the ophthalmic branch of the trigeminal ganglia (TG). These nerves are important to maintain corneal homeostasis, and nerve damage can lead to a decrease in wound healing, an increase in corneal ulceration and dry eye disease (DED), and neuropathic pain. Pathologies, such as diabetes, aging, viral and bacterial infection, as well as prolonged use of contact lenses and surgeries to correct vision can produce nerve damage. There are no effective therapies to alleviate DED (a multifunctional disease) and several clinical trials using ω-3 supplementation show unclear and sometimes negative results. …

The Aryl Hydrocarbon Receptor Undergoes Chaperone-Mediated Autophagy In Triple-Negative Breast Cancer Cells, Jinyun Chen, Yujie Yang, Wade A. Russu, William K. Chan

Pacific Faculty Work

The aryl hydrocarbon receptor (AHR) is a ligand-activated signaling molecule expressed in many cell types, including triple-negative and non-triple-negative breast cancer cells. It affects breast cancer growth and crosstalk with estrogen receptor signaling. Normally, this receptor is degraded shortly after ligand activation via the 26S proteasome. Here, we report that AHR undergoes chaperone-mediated autophagy in MDA-MB-468 triple-negative breast cancer cells. This lysosomal degradation of AHR exhibits the following characteristics: (1) it is triggered by 6 amino-nicotina-mide, starvation, and piperazinylpyrimidine compound Q18; (2) it is not observed in non-triple-negative breast cancer cells (MCF-7, T47D, and MDA-MB-361); (3) it can be inhibited …

Cryo-Electron Tomography Of Candida Glabrata Plasma Membrane Proteins, Cristina Jiménez-Ortigosa, Jennifer Jiang, Muyuan Chen, Xuyuan Kuang, Kelley R Healey, Paul Castellano, Nikpreet Boparai, Steven J Ludtke, David S Perlin, Wei Dai

Faculty, Staff and Students Publications

Fungal plasma membrane proteins have long been recognized as targets for the development of antifungal agents. Despite recent progress in experimental approaches and computational structural predictions, our knowledge of the structural dynamics and spatial distribution of these membrane proteins in the context of their native lipid environment remains limited. By applying cryo-electron tomography (cryoET) and subtomogram analysis, we aim to characterize the structural characteristics and spatial distribution of membrane proteins present in Candida glabrata plasma membranes. This study has resulted in the identification of the membrane-embedded structure of the fungal H+-ATPase, Pma1. Tomograms of the plasma membrane revealed that Pma1 …

Nephrology Publications Of Bibliographic Coupling And Co-Authorship Network Using Vos Viewer: A Scientometric Profile, Chandran Velmurugan Dr, Ramasamy G Dr

Library Philosophy and Practice (e-journal)

The study has made an attempt to explore the co-authorship network and bibliographic coupling with institutions, authors, and countries based on the research output of Nephrology. Using the Web of Science core collection citation database from the Clarivate Analytics, a total number of 2626 literature found by the researcher and the total citations in global level was 11, 993 and the total cited references were 84, 129 and the total authors was 10, 846, a total number of core journals was 595 and institutions (3494), Institution with subdivision (6630), and 108 total countries have participated in the study. The scientometric …

The Association Between Cardiovascular Disease Knowledge And Risk Factors Among African American Breast Cancer Survivors In The Deep South, Michelle S. Williams, Chizoba Anyimukwu

Journal of Health Disparities Research and Practice

Purpose: African American breast cancer survivors in the Deep South have a disproportionately high burden of cardiovascular disease (CVD) mortality. Multiple potentially modifiable CVD risk factors are highly prevalent in this population, such as high blood pressure, obesity, and poor dietary habits. The purpose of this study was to assess the association between CVD health metrics and heart disease knowledge among the target population.

Methods: The Heart Disease Knowledge Questionnaire was used to assess the participants’ knowledge of heart disease and heart disease risk factors. Questions from My Life Check were used to assess the participants cardiovascular health metrics. Multivariate …

Environmentally Marginalized Populations: The "Perfect Storm" For Infectious Disease Pandemics, Including Covid-19, Gabriella Y. Meltzer, Oyemwenosa Avenbuan, Christina Awada, Oluwakemi B. Oyetade, Tricia Blackman, Simona Kwon Drph, Mph, Esther Erdei Phd, Judith T. Zelikoff Phd

Journal of Health Disparities Research and Practice

COVID-19 has exacted a severe toll on the United States population’s physical and mental health and its effects have been felt most severely among people of color and low socioeconomic status. Using illustrative case studies, this commentary argues that in addition to COVID-19 health disparities created by psychosocial stressors such as the inability to socially distance and access quality healthcare, environmental justice communities have the additional burden of disproportionate exposure to toxic contaminants that contribute to their higher risk of COVID-19. Environmental contaminants including heavy metals and persistent organic pollutants found contaminating their nearby environments can alter the immune response, …

Are Binge Drinking Disparities By Sexual Identity Lower In U.S. States With Nondiscrimination Statutes That Include Sexual Orientation?, Naomi Greene, Renee M. Johnson, Joanne Rosen, Danielle German, Joanna E. Cohen

Journal of Health Disparities Research and Practice

Purpose Studies examining binge drinking disparities by sexual identity focus on intra- and inter-personal minority stressors experienced by lesbian, gay, and bisexual (LGB) populations. State-level statutes are powerful tools that can reduce health disparities. We examined how state-level nondiscrimination statutes that include sexual orientation as a protected ground (i.e., inclusive statutes) are associated with binge drinking disparities between LGB and straight adults. Methods We combined data from the 2015-2018 Behavioral Risk Factor Surveillance System (BRFSS), the Movement Advancement Project (MAP), and administrative data sources for information on binge drinking, sexual identity, nondiscrimination statutes, and individual and state-level factors. We included …

The Impact Of Food Insecurity Screenings And Community Food Resource Referrals For Patients With Type 2 Diabetes, Miriam Ngozi Ofili, Robin M. Lawson

Journal of Health Disparities Research and Practice

ABSTRACT

Approximately 50 million people in the United States are food insecure, which makes food insecurity (FI) one of the country’s most prevalent health issues. Food insecurity has been shown to be a contributing factor to uncontrolled Type 2 Diabetes (T2D), which affects about 34.1 million adults in the United States. The purpose of this study was to evaluate the effectiveness of integration of an electronic social determinants of health screening and community referral process for adult patients with T2D and FI. The aim was to determine if Hemoglobin A1c (HbA1c) levels are reduced in adult patients with T2D by …

Risk Factors Associated With Opioid Use Among African American Faith-Based Populations, Kelsey Christensen Ma, Jannette Berkley-Patton Phd, Alexandria Bauer Phd, Carole Bowe Thompson, Tacia Burgin

Journal of Health Disparities Research and Practice

African Americans (AAs) in the Midwest are more likely to die from an opioid overdose compared to Whites, despite lower rates of use. Little is known about factors related to opioid use among AAs residing in the Midwest, particularly church-affiliated AAs. AAs have the highest rate of church attendance among all racial/ethnic groups, and the Black Church may be an appropriate setting for prevention efforts. The present study sought to better understand factors related to opioid use among Midwestern church-affiliated AAs to inform future faith-based interventions. This study examined predictors of opioid use (ever) using survey data from Taking It …

Gender Disparity In Composition And Compensation Among Maryland Hospital Executives, Gilberto O. Lobaton, Majd Marrache Md, Varun Puvanesarajah Md, Dawn M. Laporte Md, Amit Jain Md, Shruti Aggarwal Md

Journal of Health Disparities Research and Practice

Introduction: Senior executive positions in hospitals have traditionally been held by men, and do not reflect the gender, racial, ethnic, and cultural diversities of the communities they serve. Despite sex parity in medical school graduates, women remain underrepresented in hospital executive leadership positions. In this study, the authors examined differences in gender composition and compensation of Maryland hospital executives.

Methods: The authors examined 47 Maryland hospitals’ publicly available tax forms from 2013-2018. Data collected included hospital revenue and executive positions’ count, salary, and gender. Executive positions included President and/or Chief Executive Officer (P/CEO), Chief Financial Officer (CFO), Chief Medical Officer …

Propelling Adolescents Toward Careers In Healthcare (Patch): A Medical Student Led Pipeline Program For High School Students Underrepresented In Medicine, Maggie Brownrigg, Sagar Patel Md, Kyle Roedersheimer Md, Melissa Wooten Md, Radhika Ghodasara Md, Banks Kooken Md, Iris Cheng Md

Journal of Health Disparities Research and Practice

Despite the growing diversity of the United States population, individuals from many racial and ethnic minority groups and low-income families continue to be underrepresented in the health professions. A diverse healthcare workforce would improve cultural competency and create a system better suited to address the vast health disparities in many disadvantaged communities, yet the current educational pipeline needs to expand opportunities to provide students traditionally underrepresented in medicine (UIM) a path to become a part of the healthcare field. The Propelling Adolescents Towards Careers in Healthcare (PATCH) program was founded to address this gap in the current health professions pipeline …