Medicine and Health Sciences Commons^™

Child Obesity Moderates The Association Between Poverty And Academic Achievement, Ashley W. Kranjac, Dinko Kranjac

Sociology Faculty Articles and Research

Childhood overweight and obesity are major public health problems in the United States. Children who experience poverty are 1.5 times more likely to suffer with overweight and 1.6 times more likely to have obesity. The extent to which overweight or obesity exacerbates the negative influence of socioeconomic inequality on child academic outcomes has not yet been examined. We estimated the effect of poverty on math and reading achievement trajectories using the Early Childhood Longitudinal Study (ECLS) Kindergarten class of 1998−1999 survey data and multilevel growth curve modeling techniques. Our findings indicate that the impact of obesity status is more pronounced …

Aberrant Maturation Of The Uncinate Fasciculus Follows Exposure To Unpredictable Patterns Of Maternal Signals, Steven J. Granger, Laura M. Glynn, Curt A. Sandman, Steven L. Small, Andre Obenaus, David B. Keator, Tallie Z. Baram, Hal S. Stern, Michael A. Yassa, Elyssia Poggi Davis

Psychology Faculty Articles and Research

Across species, unpredictable patterns of maternal behavior are emerging as novel predictors of aberrant cognitive and emotional outcomes later in life. In animal models, exposure to unpredictable patterns of maternal behavior alters brain circuit maturation and cognitive and emotional outcomes. However, whether exposure to such signals in humans alters the development of brain pathways is unknown. In mother–child dyads, we tested the hypothesis that exposure to more unpredictable maternal signals in infancy is associated with aberrant maturation of corticolimbic pathways. We focused on the uncinate fasciculus, the primary fiber bundle connecting the amygdala to the orbitofrontal cortex and a key …

Sequencing Of 53,831 Diverse Genomes From The Nhlbi Topmed Program, Daniel Taliun, Daniel N. Harris, Michael D. Kessler, Jedidiah Carlson, John Blangero, Joanne E. Curran, Michael C. Mahaney, Harald H. H. Goring, Ravindranath Duggirala, Juan M. Peralta

School of Medicine Publications

The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of improving diagnosis, treatment and prevention of these diseases. The initial phases of the programme focused on whole-genome sequencing of individuals with rich phenotypic data and diverse backgrounds. Here we describe the TOPMed goals and design as well as the available resources and early insights obtained from the sequence data. The resources include a variant browser, a genotype imputation server, and genomic and phenotypic data that are available through dbGaP (Database of Genotypes and …

Physician Trading Cards As A Tool To Improve Resident Joy In Medicine While Improving Patient Satisfaction, Lindsay Weiss, Mary Edmond, Sarah Varghese, Anthony Cooley

Journal of Wellness

Introduction: To combat resident physician burnout, wellness programming should include approaches that foster joy to work as a physician. Photograph trading cards have been used to improve patient satisfaction but have not been explored as a way to improve physician work satisfaction. We aimed to use trading cards to improve resident physician identification by patients’ families, as well as measure their effect on the hospital experience for patients and residents.

Methods: For a one-month period in 2019, trading cards were piloted with the nine residents assigned to the inpatient pediatrics service. Employing five-point Likert scales, surveys were administered to residents …

The Potential Of Raman Spectroscopy In The Diagnosis Of Dysplastic And Malignant Oral Lesions, Ola Ibrahim, M. Toner, Steven Flint, Hugh Byrne, Fiona Lyng

Articles

Early diagnosis, treatment and/or surveillance of oral premalignant lesions are important in preventing progression to oral squamous cell carcinoma (OSCC). The current gold standard is through histopathological diagnosis, which is limited by inter and intra observer and sampling errors. The objective of this work was to use Raman spectroscopy to discriminate between benign, mild, moderate and severe dysplasia and OSCC in formalin fixed paraffin preserved (FFPP) tissues. The study included 72 different pathologies from which 17 were benign lesions, 20 mildly dysplastic, 20 moderately dysplastic, 10 severely dysplastic and 5 invasive OSCC. The glass substrate and paraffin wax background were …

The Rac-Gef Tiam1 Promotes Dendrite And Synapse Stabilization Of Dentate Granule Cells And Restricts Hippocampal-Dependent Memory Functions, Jinxuan Cheng, Federico Scala, Francisco A Blanco, Sanyong Niu, Karen Firozi, Laura Keehan, Shalaka Mulherkar, Emmanouil Froudarakis, Lingyong Li, Joseph G Duman, Xiaolong Jiang, Kimberley F Tolias

Faculty, Staff and Students Publications

The dentate gyrus (DG) controls information flow into the hippocampus and is critical for learning, memory, pattern separation, and spatial coding, while DG dysfunction is associated with neuropsychiatric disorders. Despite its importance, the molecular mechanisms regulating DG neural circuit assembly and function remain unclear. Here, we identify the Rac-GEF Tiam1 as an important regulator of DG development and associated memory processes. In the hippocampus, Tiam1 is predominantly expressed in the DG throughout life. Global deletion of Tiam1 in male mice results in DG granule cells with simplified dendritic arbors, reduced dendritic spine density, and diminished excitatory synaptic transmission. Notably, DG …

Is The Acsm And Friend Metabolic Equations Valid For Assessing Cardiorespiratory Fitness Among 18-34 Aged Men? : Preliminary Results, Marc-Olivier Dugas, Laurie Simard, Tommy Chevrette, Martin Lavalliere

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 2: Issue 1, Article 2, 2021. Metabolic equations, such as ACSM and FRIEND, are used worldwide to indirectly measure the VO₂max in adults, but lack of accuracy seems to occur. 30 men of 18-34 years old performed a maximal incremental test on a treadmill during which direct VO₂max measurements was taken and then have been compared to ACSM and FRIEND metabolic equations. Point of application #1: Better evaluation and exercise prescription among athletic populations. Point of application #2: Act in prevention among sedentary and symptomatic populations. Point of application …

2021-02-09_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

The webpage was obtained from Michigan's Coronavirus Cumulative Data page, under the link Hospitals. Data is self-reported by hospitals daily to the EM Resource System per MDHHS Director Robert Gordon's Emergency Order.

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2021-02-09_Michiganoverview_Covidvaccinestats, Michigan Department Of Health & Human Services

Michigan COVID-19 Vaccine Data

The COVID Vaccine Dashboard page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/0,9753,7-406-98178_103214-547150--,00.html.

Data is updated Monday through Saturday. Previously reported numbers of administered vaccine doses may change as new data are received. A possible lag in reporting vaccine doses will result in increases in numbers previously reported.

This report is created by the Michigan Department of Health and Human Services Division of Immunization from data reported to the Michigan Care Improvement Registry (MCIR).

The dashboard contained the tabs Vaccines Shipped, Distribution Trend, Doses Administered, Doses by Vaccine, Doses Metrics, Coverage, Enrolled Providers …

Ua12/2/1 College Heights Herald, Vol. 96, No. 17, Wku Student Affairs

WKU Administration Documents

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news. This issue contains articles:

• Tolbert, Ellie. Student Teaching Transforms to Allow Virtual Instruction
• Murray, Debra. Provost Reflects on Time at WKU, As an Educator as She Prepares for Retirement – Cheryl Stevens
• Gaskin, Loren. Up for Debate: Potter College Name Change
• Meyer-Thornton, Zane & Jack Dobbs. The Sixth Annual Puppy Bowl
• Snyder, Sean. Local Doctor Finds Life-long Passion in Race-walking – Doug Johnson
• Toennies, Drew. Lady Toppers Travel to Face Top Conference Foe Rice – Basketball
• Snyder, Sean. Lady Toppers to Host Bellarmine for Home Opener – Soccer
• Moore, …

2021-02-09_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-526911--,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The data below represents a cumulative total of confirmed COVID-19 resident cases, cumulative total of suspected and confirmed resident deaths, cumulative total of confirmed COVID-19 staff cases, and cumulative total of suspected and confirmed staff deaths reported by SNFs in Michigan since January 1, 2020. Case numbers are provisional and may change …

2021-02-09_Michiganoverview_Covidlongtermcare_Update2, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-526911--,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The data below represents a cumulative total of confirmed COVID-19 resident cases, cumulative total of suspected and confirmed resident deaths, cumulative total of confirmed COVID-19 staff cases, and cumulative total of suspected and confirmed staff deaths reported by SNFs in Michigan since January 1, 2020. Case numbers are provisional and may change …

2021-02-09_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Monday - Saturday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …

Coronavirus Update 2-9-21, The Coronavirus Planning Team

University Briefings & Virtual Events

Student Activities has lined up a number of fun and informational activities for you this week --Updated Frequently Asked Questions --Campus Clear --Contact Tracing Update --Importance of Avoiding Gatherings --Vaccines for Those 65 and Older --Spring Sports.

Effects Of Auditory Cueing On Cadence And Gait Pattern, Andrew Carballo, Matthew Chang, Brian Hirmiz, Nicolette Lambright, Vivian Lee, Marla Lewis, Martin Nguyen, Matthew Gothong, Rahul Soangra

Physical Therapy Faculty Articles and Research

A large portion of the population participate in gait rehabilitation, especially those with conditions such as increased fall risk such as stroke, or Parkinson’s Disease. Some studies have shown that auditory cues help improve gait and reduce fall risk, but relationship with gait patterns is missing. In this study, eight participants walked at their preferred cadence and at increased and reduced cadence by 20%. We found that step length and step width were not significantly different in all walking conditions. Decreased cadence resulted in an increase of swing time, stance time, stride time, and stance to swing ratio, and a …

Health And Kinesiology News, Georgia Southern University

Health Sciences & Kinesiology: News & Publications (2015-2023)

• Faculty and Students Conduct Fitness Assessments on Local Firefighters

5Th Generation Vs 4Th Generation Troponin T In Predicting Major Adverse Cardiovascular Events And All-Cause Mortality In Patients Hospitalized For Non-Cardiac Indications: A Cohort Study, Vedant Gupta, Marc Paranzino, Talal Alnabelsi, Karam Ayoub, Joshua Eason, Andin Mullis, John R. Kotter, Andrew Parks, Levi May, Sethabhisha Nerusu, Chen Dai, Daniel Cleland, Steve W. Leung, Vincent L. Sorrell

Gill Heart & Vascular Institute Faculty Publications

OBJECTIVE: The frequency and implications of an elevated cardiac troponin (4^th or 5^th generation TnT) in patients outside of the emergency department or presenting with non-cardiac conditions is unclear.

METHODS: Consecutive patients aged 18 years or older admitted for a primary non-cardiac condition who had the 4^th generation TnT drawn had the 5^th generation TnT run on the residual blood sample. Primary and secondary outcomes were all-cause mortality (ACM) and major adverse cardiovascular events (MACE) respectively at 1 year.

RESULTS: 918 patients were included (mean age 59.8 years, 55% male) in the cohort. 69% had elevated …

Smoking Cessation Interventions In South Asian Countries: Protocol For Scoping Review, Sajid Iqbal, Rubina Barolia, Laila Ladak, Pammla Petrucka

School of Nursing & Midwifery

Introduction: Unfortunately, like many other health risks, smoking rate has been on the rise in developing countries. Half of current smokers in the world reside in only three countries of Asia that include India. Many smoking cessation interventions that were developed and successfully implemented in the context of developed countries have not been equally successful in South Asia. Hence, there is a dire need of culturally relevant smoking cessation interventions. We propose a scoping review with objectives to explore the extent and nature of interventions for smoking cessation and its associated factors in South Asian Region by systematically reviewing the …

2021-02-09_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

2021-02-09_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

Return To Play Rates After Ulnar Nerve Transposition And Decompression Surgery: A Retrospective Analysis., Christopher J Hadley, Anant Dixit, John Kunkel, Alex E White, Michael G. Ciccotti, Steven B. Cohen, Christopher C Dodson

Rothman Institute Papers

Background: Medial elbow pain is a common complaint in overhead throwing athletes. The throwing motion places repetitive tensile and compressive forces on the elbow resulting in significant stress across the ulnohumeral joint. This stress can result in soft-tissue, ligamentous, and ulnar nerve injury. The purpose of this study was to retrospectively investigate the clinical findings and outcomes, including return to play rates, of patients who underwent ulnar nerve transposition surgery for isolated ulnar neuritis.

Methods: Throwing athletes who underwent isolated, primary ulnar nerve transposition surgery over an eight-year period, 2009 to 2017, were identified and included in our analysis. Nonthrowing …

Machine Intelligence Identifies Soluble Tnfa As A Therapeutic Target For Spinal Cord Injury, J. R. Huie, A. R. Ferguson, N. Kyritsis, J. Z. Pan, K.-A. Irvine, J. L. Nielson, P. G. Schupp, M. C. Oldham, John C. Gensel, A. Lin, M. R. Segal, R. R. Ratan, J. C. Bresnahan, M. S. Beattie

Spinal Cord and Brain Injury Research Center Faculty Publications

Traumatic spinal cord injury (SCI) produces a complex syndrome that is expressed across multiple endpoints ranging from molecular and cellular changes to functional behavioral deficits. Effective therapeutic strategies for CNS injury are therefore likely to manifest multi-factorial effects across a broad range of biological and functional outcome measures. Thus, multivariate analytic approaches are needed to capture the linkage between biological and neurobehavioral outcomes. Injury-induced neuroinflammation (NI) presents a particularly challenging therapeutic target, since NI is involved in both degeneration and repair. Here, we used big-data integration and large-scale analytics to examine a large dataset of preclinical efficacy tests combining five …

Methylation Of The D2 Dopamine Receptor Affects Binding With The Human Regulatory Proteins Par-4 And Calmodulin, Alexander Bowitch, Ansuman Sahoo, Andrea M. Clark, Christiana Ntangka, Krishna K. Raut, Paul Gollnick, Michael C. Yu, Steven M. Pascal, Sarah E. Walker, Denise M. Ferkey

Chemistry & Biochemistry Faculty Publications

No abstract provided.

Natural Genetic Variation Determines Microglia Heterogeneity In Wild-Derived Mouse Models Of Alzheimer's Disease., Hongtian Stanley Yang, Kristen D. Onos, Kwangbom Choi, Kelly J Keezer, Daniel A Skelly, Gregory W. Carter, Gareth R Howell

Faculty Research 2021

Genetic and genome-wide association studies suggest a central role for microglia in Alzheimer's disease (AD). However, single-cell RNA sequencing (scRNA-seq) of microglia in mice, a key preclinical model, has shown mixed results regarding translatability to human studies. To address this, scRNA-seq of microglia from C57BL/6J (B6) and wild-derived strains (WSB/EiJ, CAST/EiJ, and PWK/PhJ) with and without APP/PS1 demonstrates that genetic diversity significantly alters features and dynamics of microglia in baseline neuroimmune functions and in response to amyloidosis. Results show significant variation in the abundance of microglial subtypes or states, including numbers of previously identified disease-associated and interferon-responding microglia, across the …

Asymmetric Load Carriage At Shoulder Height Affects Temporal Gait Characteristics Among Food Service Workers, Christopher Espino, Robin Faustino, Tiffany Franco, Angel Reign Galvan, Matthew Gothong, Ennis Khaleq, Cody Occhino, Rahul Soangra

Physical Therapy Faculty Articles and Research

Slips and falls are common injuries among restaurant and food service workers. It is estimated that food service workers have 60% higher rate of occupational injury or illness than workers in other industry. This study investigates effects of asymmetric load carriage at shoulder level on gait characteristics. Each participant walked with a service tray held at shoulder height. Each participant’s gait was analyzed under 3 different load walking conditions, no load walking (NLW), intermediate load walking (ILW) (2.5% BW), and maximum load walking (MLW) (5% BW). We found that participants walked significantly slower with gait cycle time 1.125s versus 1.150 …

Load Carriage Affects Kinematics During Ingress And Egress On Simulated Travelators, Alex Charbonneau, Ben Garson, Fiona Bisoffi, Stephanie Esparza, Miral Bhakta, Luke Bailey, Rahul Soangra

Physical Therapy Faculty Articles and Research

Technology advancements has impacted the quality of life in the modern world. Nowadays travelators found popularly as conveyers in airports have been widely used but it is not known how load carriage affects Ingress/egress on travelators. Ten healthy young adults stepped off a metal platform onto a forward moving treadmill belt at a given speed and then stepped on to a second platform. Data was collected to understand how load carriage could influence ingress and egress in participants. Participants were tested for four conditions (load, No load, speed of 0.3 m/s and 0.6 m/s). Load carriage at speed 0.6 m/s …

Copper Oxide Nanoparticle Diameter Mediates Serum-Sensitive Toxicity In Beas-2b Cells, Angie S. Morris, Brittany E. Givens, Aaron Silva, Aliasger K. Salem

Chemical and Materials Engineering Faculty Publications

Copper oxide (CuO) nanoparticles (NPs) are abundant in manufacturing processes, but they are an airway irritant. In vitro pulmonary toxicity of CuO NPs has been modeled using cell lines such as human bronchial epithelial cell line BEAS-2B. In 2D in vitro culture, BEAS-2B undergoes squamous differentiation due to the presence of serum. Differentiation is part of the repair process of lung cells in vivo that helps to preserve the epithelial lining of the respiratory tract. Herein, the effects of serum on the hydrodynamic diameter, cellular viability, cellular differentiation, and cellular uptake of 5 and 35 nm CuO NPs are investigated, …

Surface Inclination Influences Fall Risk And Lower Extremity Joint Moments During Walking, Rachel Kling, Alex Chung, Courtney Cox, Emily Kimbro, Jim Grodzielanek, Stephen Ayres, Shireen Hosseini, Michael Shiraishi, Rahul Soangra

Physical Therapy Faculty Articles and Research

Falls present a large danger to the geriatric population, with one in three individuals over the age of 65 experiencing at least one fall annually. With most falls occurring while walking, the relationship between inclined walking and fall risk has not been fully explored. In this study, 16 healthy young participants (age: 26.8 ±5.4 years, height: 175.0±11.0 cm, weight: 68.2 ±19.9 kg) walked on a treadmill with level surface and 10 degrees incline/decline in a virtual environment laboratory. We found that gait parameters and lower extremity joint moments were affected by surface inclination. These observed changes in joint moments and …

Virucidal Activity Of Chlorine Dioxide Gas For Reduction Of Coronavirus On Surfaces And Ppe, Jeffrey Driver, George Lukasik, Marie Bourgeois, Patricia Tam, Raymond Harbison

School of Pharmacy Faculty Articles

A coronavirus (SARS-CoV-2) has caused a global pandemic and associated morbidity and mortality resultant from COVID-19. As a result of efforts to control direct (person to person) and indirect (contaminated objects, surfaces, indoor air) transmission of the virus, various interventions have been evaluated. Studies were conducted to evaluate the efficacy of commercially available chlorine dioxide (CD) products to reduce viral loads on PPE (face masks) and surfaces using a novel dry gas release intervention. The efficacy of CD slow release 30-day sachets was tested on N95 face masks inoculated with human coronavirus OC43 in suspension. One sachet was placed with …

The Utility Of Genetic Risk Score To Improve Performance Of Frax For Fracture Prediction In Us Postmenopausal Women, Xiangxue Xiao, Qing Wu

School of Public Health Faculty Research

The ability of the fracture risk assessment tool (FRAX) in discriminating fracture and non-fracture in postmenopausal women remains suboptimal. Adding a genetic profile may improve the performance of FRAX. Three genetic risk scores (GRSs) (GRS_fracture, GRS_BMD, GRS_eBMD) were calculated for each participant in the Women’s Health Initiative Study (n = 23,981), based on the summary statistics of three comprehensive osteoporosis-related genome-wide association studies (GWAS). The primary outcomes were incident major osteoporotic fracture (MOF) and hip fracture (HF). The association between each GRS and fracture risk were evaluated in separate Cox Proportional Hazard models, with FRAX clinical risk factors adjusted for. …