Medicine and Health Sciences Commons^™

The Effect Of Different Methods To Identify, And Scenarios Used To Address Energy Intake Misestimation On Dietary Patterns Derived By Cluster Analysis, Geraldine Lo Siou, Alianu K. Akawung, Nathan M. Solbak, Kathryn L. Mcdonald, Ala Al Rajabi, Heather K. Whelan, Sharon I. Kirkpatrick

All Works

Background: All self-reported dietary intake data are characterized by measurement error, and validation studies indicate that the estimation of energy intake (EI) is particularly affected. Methods: Using self-reported food frequency and physical activity data from Alberta’s Tomorrow Project participants (n = 9847 men 16,241 women), we compared the revised-Goldberg and the predicted total energy expenditure methods in their ability to identify misreporters of EI. We also compared dietary patterns derived by k-means clustering under different scenarios where misreporters are included in the cluster analysis (Inclusion); excluded prior to completing the cluster analysis (ExBefore); excluded after completing the cluster analysis (ExAfter); …

Exercise And Nutrition Impact On Osteoporosis And Sarcopenia—The Incidence Of Osteosarcopenia: A Narrative Review, Sousana K. Papadopoulou, Konstantinos Papadimitriou, Gavriela Voulgaridou, Evridiki Georgaki, Eudoxia Tsotidou, Olga Zantidou, Dimitrios Papandreou

All Works

Osteoporosis and sarcopenia are diseases which affect the myoskeletal system and often occur in older adults. They are characterized by low bone density and loss of muscle mass and strength, factors which reduce the quality of life and mobility. Recently, apart from pharmaceutical interventions, many studies have focused on non-pharmaceutical approaches for the prevention of osteoporosis and sarcopenia with exercise and nutrition to being the most important and well studied of those. The purpose of the current narrative review is to describe the role of exercise and nutrition on prevention of osteoporosis and sarcopenia in older adults and to define …

Purkis And Mastermans' "The Awesome Autistic Go-To Guide: A Practical Handbook For Autistic Teens And Tweens" (Book Review), Susanah J. Wilson Hanson

The Christian Librarian

No abstract provided.

Forsyth And Powers' "The Bigger Picture Book Of Amazing Dyslexics And The Jobs They Do" (Book Review), Lillian Purdy

The Christian Librarian

No abstract provided.

Effectiveness Of Simulation-Based Clinical Skills Training For Medical Students In Respiratory Medicine: A Pilot Study, Russell S. Martins, Saniya Sabzwari, Meesha Iqbal

Medical College Documents

Objective: To assess the effectiveness of high-fidelity simulation-based medical education (HF-SBME) in teaching and learning respiratory clinical examination in medical students.
Study design: Quasi-experimental pilot study.
Place and duration of study: The Aga Khan University, Karachi, from November 2018 to January 2020. Methodology: This study was conducted amongst third year medical students at the University. Students were assigned to intervention (IG) or control groups (CG). The IG underwent training for the respiratory clinical examination on a high-fidelity simulator mannequin, while the CG received the conventional practice session on standardised patients. Students were assessed on their respiratory clinical examination skills in …

Effect Of Renin-Angiotensin System Inhibitors On Acute Kidney Injury Among Patients Undergoing Cardiac Surgery: A Review And Meta-Analysis, Han Zhou, Jingui Xie, Zhichao Zheng, Oon Cheong Ooi, Haidong Luo

Research Collection Lee Kong Chian School Of Business

Acute kidney injury (AKI) is a frequent complication of cardiac surgery, which can lead to higher mortality and long-term renal function impairment. The effect of perioperative renin-angiotensin system inhibitors (RASi) therapy on AKI incidence in patients undergoing cardiac surgery remains controversial. We reviewed related studies in PubMed, Scopus, and Cochrane Library from inception to February 2020. Two randomized controlled trials and 21 cohort studies were included in the meta-analysis, involving 76,321 participants. The pooled odds ratio and 95% confidence interval were calculated using the DerSimonian and Laird random-effects model. The results showed no significant association between perioperative RASi therapy and …

News Media Trust And Mistrust During The Covid-19 Pandemic, Kaitlyn Seiter

Graduate Theses and Dissertations

With the uncertainty and growing information surrounding the COVID-19 pandemic, news media consumption has increased drastically compared to pre-pandemic consumption. At the start of the pandemic, 94% of Americans reported closely following COVID-19 news, with more than half of Americans spending more than two hours consuming COVID-19 news everyday (SSRS, 2020). With the news media serving as a critical source of information through this public health crisis, the public’s reactions, behaviors, and attitudes to the pandemic stem from the level of trust they have in the news media to share COVID-19 information. Because of this, this study examines trust in …

Impact Of Fish Oil On Intestinal Permeability, Inflammation, And Performance In Swine, Anthony Fernando Alberto

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Our research examined the effects of fish oil supplementation on intestinal permeability, systemic inflammation and performance in piglets. An lipopolysaccharide (LPS) challenge was done to stimulate the synthesis and release of the cytokines, in an effort to mimic the immune response that piglets would have when facing stress or pathogen challenge. Fish oil increased feed intake but did not affect growth when compared to control. Total fatty acid digestibility increased by 6% when fish oil was included in the diet. Also, we observed a 16% increase on 16-carbon fatty acids digestibility. Fish oil did not affect the plasma …

Occurrence, Diversity And Distribution Of Trypanosoma Infections In Cattle Around The Akagera National Park, Rwanda, S. Richard Gashururu, Ndichu Maingi, Samuel M. Githigia, Methode N. Gasana, Peter O. Odhiambo, Dennis O. Getange, Richard Habimana, Giuliano Cecchi, Weining Zhao, James Gashumba, Joel L. Bargul, Daniel K. Masiga

All Peer-Reviewed Publications

Background African Trypanosomiases threaten the life of both humans and animals. Trypanosomes are transmitted by tsetse and other biting flies. In Rwanda, the African Animal Trypanosomiasis (AAT) endemic area is mainly around the tsetse-infested Akagera National Park (NP). The study aimed to identify Trypanosoma species circulating in cattle, their genetic diversity and distribution around the Akagera NP. Methodology A cross-sectional study was carried out in four districts, where 1,037 cattle blood samples were collected. The presence of trypanosomes was determined by microscopy, immunolog-ical rapid test VerY Diag and PCR coupled with High-Resolution Melt (HRM) analysis. A parametric test (ANOVA) was …

Satellite-Based Modelling Of Potential Tsetse (Glossina Pallidipes) Breeding And Foraging Sites Using Teneral And Non-Teneral Fly Occurrence Data, Stella Gachoki, Thomas Groen, Anton Vrieling, Michael Okal, Andrew Skidmore, Daniel Masiga

All Peer-Reviewed Publications

Background: African trypanosomiasis, which is mainly transmitted by tsetse flies (Glossina spp.), is a threat to public health and a significant hindrance to animal production. Tools that can reduce tsetse densities and interrupt disease transmission exist, but their large-scale deployment is limited by high implementation costs. This is in part limited by the absence of knowledge of breeding sites and dispersal data, and tools that can predict these in the absence of ground-truthing. Methods: In Kenya, tsetse collections were carried out in 261 randomized points within Shimba Hills National Reserve (SHNR) and villages up to 5 km from the reserve …

Root Exudate Chemical Cues Of An Invasive Plant Modulate Oviposition Behavior And Survivorship Of A Malaria Mosquito Vector, Trizah K. Milugo, David P. Tchouassi, Reginald A. Kavishe, Rhoel R. Dinglasan, Baldwyn Torto

All Peer-Reviewed Publications

Gravid female Anopheles gambiae mosquitoes identify suitable oviposition sites through a repertoire of cues, but the influence of allelochemicals, especially root phytochemicals in modulating this behavior and impacting subsequent progeny bionomics remains unexplored. We addressed these questions in the malaria vector Anopheles gambiae and its invasive host plant Parthenium hysterophorus. Using chemical analysis combined with laboratory behavioral assays, we demonstrate that a blend of terpenes, namely α-pinene, α-phellandrene, β-phellandrene, 3-carene and (E)-caryophyllene emitted from P. hysterophorus root exudate treated-water attracted gravid females. However, fewer eggs (55%) hatched in this treatment than in control water (66%). The sesquiterpene lactone parthenin, identified …

Feasibility Of Implementing Recommendations To Improve Neglected Tropical Diseases Surveillance And Response In Kenya: A Modified Delphi Study, Arthur K.S. Ng’Etich, Kuku Voyi, Clifford M. Mutero

All Peer-Reviewed Publications

Background: Effective health information systems (HIS) are critical towards achieving timely response to preventive chemotherapy neglected tropical diseases (PC-NTDs) and their eventual elimination. Strengthened HIS enable prompt case detection and effective response to halt disease transmission and prevent probable outbreaks. This study aimed to assess the importance and feasibility of implementing recommendations for improving surveillance core functions, support functions and surveillance attributes concerning PC-NTDs in Kenya. Methods: A descriptive web-based Delphi process comprising of two survey rounds was used to achieve group consensus on the importance of recommended actions and feasibility of their implementation. In the first round, participants were …

An Update On The Distribution Of Glossina (Tsetse Flies) At The Wildlife-Human-Livestock Interface Of Akagera National Park, Rwanda, Richard S. Gashururu, Samuel M. Githigia, Methode N. Gasana, Richard Habimana, Ndichu Maingi, Giuliano Cecchi, Massimo Paone, Weining Zhao, Daniel K. Masiga, James Gashumba

All Peer-Reviewed Publications

Background: Glossina (tsetse flies) biologically transmit trypanosomes that infect both humans and animals. Knowledge of their distribution patterns is a key element to better understand the transmission dynamics of trypanosomosis. Tsetse distribution in Rwanda has not been well enough documented, and little is known on their current distribution. This study determined the current spatial distribution, abundance, diversity, and seasonal variations of tsetse flies in and around the Akagera National Park. Methods: A longitudinal stratified sampling following the seasons was used. Biconical traps were deployed in 55 sites for 6 consecutive days of each study month from May 2018 to June …

Genomic Analysis Reveals Independent Evolution Of Plasmodium Falciparum Populations In Ethiopia, Deriba Abera, Caleb K. Kibet, Teshome Degefa, Lucas Amenga-Etego, Joel L. Bargul, Lemu Golassa

All Peer-Reviewed Publications

Background: Plasmodium falciparum parasite populations in Ethiopia have been experiencing local selective pressures from drugs and immunity, leading to evolutionary adaptation. However, there was a paucity of data on genomic characterization and evolutionary adaptations of P. falciparum isolates from the central area of Ethiopia. Methods: Whole-genome analysis of 25 P. falciparum isolates from central Ethiopia, specifically from West Arsi, were studied to determine their genetic diversity, population structures, and signatures of selection in known drug resistance alleles against global isolates from Cambodia, Thailand, DR Congo, and Malawi. Results: A total of 18,517 high-quality single-nucleotide polymorphisms (SNPs) were identified in Ethiopian …

Evaluation Of Health Surveillance System Attributes: The Case Of Neglected Tropical Diseases In Kenya, Arthur K.S. Ng’Etich, Kuku Voyi, Clifford M. Mutero

All Peer-Reviewed Publications

Background: Control of preventive chemotherapy-targeted neglected tropical diseases (PC-NTDs) relies on strengthened health systems. Efficient health information systems provide an impetus to achieving the sustainable development goal aimed at ending PC-NTD epidemics. However, there is limited assessment of surveillance system functions linked to PC-NTDs and hinged on optimum performance of surveillance system attributes. The study aimed to evaluate surveillance system attributes based on healthcare workers’ perceptions in relation to PC-NTDs endemic in Kenya. Methods: A cross-sectional health facility survey was used to purposively sample respondents involved in disease surveillance activities. Consenting respondents completed a self-administered questionnaire that assessed their perceptions …

Ehrlichia Spp. Close To Ehrlichia Ruminantium, Ehrlichia Canis, And “Candidatus Ehrlichia Regneryi” Linked To Heartwater-Like Disease In Kenyan Camels (Camelus Dromedarius), Mario Younan, Daniel O. Ouso, Boku Bodha, Edward K. Keitany, Hezron O. Wesonga, Rinah Sitawa, Joshua Kimutai, Wilson Kuria, Wario Sori Sake, Nicholas Svitek, Tobias Landmann, Diba Dida Wako, Jandouwe Villinger

All Peer-Reviewed Publications

We present findings from an outbreak of a heartwater-like disease in camels that killed at least 2000 adult animals in Kenya in 2016. Clinical signs included excitability, head pressing, aimless wandering, recumbency, and fast breathing followed by death after about 4 days. The observed morbidity in one herd was 40% with an average mortality of 7.5% in animals that received early antibiotic treatments. In untreated adults, the case fatality rate reached 100%. Gross pathology showed pulmonary edema, pleural exudate, hydrothorax, hydropericardium, ascites, enlarged “cooked” liver, nephrosis, and blood in the abomasum and intestine. Using established PCR-based protocols for tick-borne pathogens, …

Molecular Detection Of Leishmania Donovani, Leishmania Major, And Trypanosoma Species In Sergentomyia Squamipleuris Sand Flies From A Visceral Leishmaniasis Focus In Merti Sub-County, Eastern Kenya, Barrack O. Owino, Jackline Milkah Mwangi, Steve Kiplagat, Hannah Njiriku Mwangi, Johnstone M. Ingonga, Alphine Chebet, Philip M. Ngumbi, Jandouwe Villinger, Daniel K. Masiga, Damaris Matoke-Muhia

All Peer-Reviewed Publications

Background: Visceral leishmaniasis (VL) and zoonotic cutaneous leishmaniasis (ZCL) are of public health concern in Merti sub-County, Kenya, but epidemiological data on transmission, vector abundance, distribution, and reservoir hosts remain limited. To better understand the disease and inform control measures to reduce transmission, we investigated the abundance and distribution of sand fly species responsible for Leishmania transmission in the sub-County and their blood-meal hosts. Methods: We conducted an entomological survey in five villages with reported cases of VL in Merti sub-County, Kenya, using CDC miniature light traps and castor oil sticky papers. Sand flies were dissected and identified to the …

Assessment Of Surveillance Core And Support Functions Regarding Neglected Tropical Diseases In Kenya, Arthur K.S. Ng’Etich, Kuku Voyi, Clifford M. Mutero

All Peer-Reviewed Publications

Background: Effective surveillance and response systems are vital to achievement of disease control and elimination goals. Kenya adopted the revised guidelines of the integrated disease surveillance and response system in 2012. Previous assessments of surveillance system core and support functions in Africa are limited to notifiable diseases with minimal attention given to neglected tropical diseases amenable to preventive chemotherapy (PC-NTDs). The study aimed to assess surveillance system core and support functions relating to PC-NTDs in Kenya. Methods: A mixed method cross-sectional survey was adapted involving 192 health facility workers, 50 community-level health workers and 44 sub-national level health personnel. Data …

Gene Co-Expression Network Analysis Of Trypanosoma Brucei In Tsetse Fly Vector, Kennedy W. Mwangi, Rosaline W. Macharia, Joel L. Bargul

All Peer-Reviewed Publications

Background: Trypanosoma brucei species are motile protozoan parasites that are cyclically transmitted by tsetse fly (genus Glossina) causing human sleeping sickness and nagana in livestock in sub-Saharan Africa. African trypanosomes display digenetic life cycle stages in the tsetse fly vector and in their mammalian host. Experimental work on insect-stage trypanosomes is challenging because of the difficulty in setting up successful in vitro cultures. Therefore, there is limited knowledge on the trypanosome biology during its development in the tsetse fly. Consequently, this limits the development of new strategies for blocking parasite transmission in the tsetse fly. Methods: In this study, RNA-Seq …

Widening Spinal Injury Research To Consider All Supraspinal Cell Types: Why We Must And How We Can, Murray G. Blackmore, Eliazbeth Batsel, Pantelis Tsoulfas

Biomedical Sciences Faculty Research and Publications

The supraspinal connectome consists of dozens of neuronal populations that project axons from the brain to the spinal cord to influence a wide range of motor, autonomic, and sensory functions. The complexity and wide distribution of supraspinal neurons present significant technical challenges, leading most spinal cord injury research to focus on a handful of major pathways such as the corticospinal, rubrospinal, and raphespinal. Much less is known about many additional populations that carry information to modulate or compensate for these main pathways, or which carry pre-autonomic and other information of high value to individuals with spinal injury. A confluence of …

The Disrupt: A Measure Of Parent Distraction With Phones And Mobile Devices And Associations With Depression, Stress, And Parenting Quality., Brandon T. Mcdaniel Phd

Health Services and Informatics Research

Abstract

The landscape of modern parenting has shifted as an increasing number of parents have and utilize smartphones and other mobile devices throughout the day. A validated measure of parent distraction with these devices is needed in the field. It is important to have a validated measure of parent distraction with mobile devices (e.g., phubbing, technoference), as this distraction can be common at times and could negatively impact the quality of parenting that children receive. In the current study, I developed a brief, parent-reported survey measure of parent distraction (DISRUPT), examined its reliability and validity (convergent, divergent) in two survey …

Genetic Characterization Of Banteng (Bos Javanicus) Populations In Thailand For Conservation, Sirinart Chaichanathong, Worata Klinsawat, Manakorn Sukmak, Apichaya Sakulthai, Worawidh Wajjwalku, Supaphen Sripiboon, Nongnid Kaolim, Seree Nakbhun, Burachat Tunpradit, Tarasak Nipanunt, Wanlaya Tipkantha, Marnoch Yindee, Nikorn Thongtip

The Thai Journal of Veterinary Medicine

Banteng (Bos javanicus), an endangered, wild ungulate, plays a major role in seed dispersal and as a prey animal in Thailand. The population of wild banteng is threatened by poaching and habitat losses. Captive breeding management of banteng has been established and reintroduction of banteng has been successful in some areas. This study investigated the genetic variation of wild and captive banteng, based on mitochondrial DNA (mtDNA) and the Y-chromosome. The mtDNA analysis revealed three novel maternal haplotypes. The Y-chromosome analysis showed two Y-chromosome haplotypes based on the SRY region in the Thai population. This region may be useful as …

Evaluating The Effects Of Prunus Laurocerasus Seed, Fruit And Leaf Extracts On Hyperglycaemia, Insulin Sensitivity And Anti-Oxidative Activities In Experimental Diabetes In Rat, Hamit Uslu, Gözde Atila Uslu

The Thai Journal of Veterinary Medicine

Although insulin resistance is widely accepted as one of the main characteristics of type 2 diabetes, there are studies suggesting that there is a link between the development of type 1 diabetes and insulin resistance in recent years. Therefore, in this study, it was aimed to investigate the effects of Prunus laurocerasus (PL) seeds, fruit and leaf extracts on hyperglycemia, adiponectin and irisin levels which are known to be effective in the mechanisms of insulin sensitivity, and oxidative stress in rats with type 1 diabetes. The study groups were as follows: normoglycaemic (NC), diabetic control (DC), diabetic + seed extract …

Prevalence Of Shiga Toxin-Producing Escherichia Coli In Buffaloes On Smallholdings In Coastal Area In Bangladesh, Md Shahriar Mannan, Farzana Rabbi, Md Gholam Kibria, Sirazul Islam, Md. Bayzid, Zamila Bueaza Bupasha, Md Zohorul Islam, Md Samun Sarker, Paritosh Kumar Biswas

The Thai Journal of Veterinary Medicine

Shiga toxin-producing Escherichia coli (STEC) is an important causal agent of food borne diseases. Although the presence of STEC has been reported in cattle, goat, and sheep in previous studies in Bangladesh, there is seemingly no information on sorbitol non-fermenting STEC (SN-F STEC) carriage in buffalo. We aimed to assess the prevalence of SN-F STEC and to identify common virulence genes in SN-F STEC strains from apparently healthy buffaloes on smallholdings in coastal area in Bangladesh. Total 308 buffaloes on smallholdings in Patenga and Anwara Upazila, Chattogram division, Bangladesh were randomly sampled by collecting a swab from the recto-anal junction …

Antifungal Activity Of Green Sulfur Nanoparticles Synthesized Using Catharanthus Roseus Extract Against Microsporum Canis, Akarapon Chantongsri, Patchara Phuektes, Glenn N. Borlace, Jareerat Aiemsaard

The Thai Journal of Veterinary Medicine

Elemental sulfur has been used for a long time to treat superficial mycoses in both medical and veterinary practices, but effective treatment requires high concentrations of sulfur. Encapsulation of sulfur in nanoparticles can potentially allow the delivery of high concentrations of sulfur to infections. Sulfur nanoparticles were synthesized from Catharanthus roseus extract and sodium sulfide at various pH conditions (4, 6, and 7). Particle identification and characterizations were performed by X-ray diffraction analysis (XRD), scanning electron microscopy (SEM), and dynamic light scattering analysis. Broth microdilution and time-kill assays were used to determine the antifungal effect against Microsporum canis DMST29297. The …

Potential Risk Factors For Brachyspira Hyodysenteriae, Lawsonia Intracellularis And Salmonella Spp. Infection And Their Prevalence In Commercial Swine Farms In Thailand, Morakot Nuntapaitoon, Sawang Katedangsakulwut, Rachod Tantilertcharoen, Napawan Bunpapong, Nanthiya Iampraphat, Suphadtra Therarachatamongkol, Jeremy Gatine

The Thai Journal of Veterinary Medicine

The aims of the present study were to evaluate the prevalence for Brachyspira hyodysenteriae, Lawsonia intracellularis and Salmonella spp. in pig feces and to identify their risk factors in 20 commercial swine farms in Thailand. The cross-sectional study was carried out from 20 farrow-to-finishing commercial swine farms in part of Thailand including the north (n=5), northeast (n=4), east (n=5), west (n=4) and south (n=1). A total of 589 fecal samples were randomly collected from 12 (n=200), 16 (n=196) and 20 (n=193) aged a week-old in each farm. All samples were analyzed for the detection of B. hyodysenteriae, L. intracellularis and …

Activation-Induced Cell Death Of Nk Cells In Canine Atopic Dermatitis Revealed By Droplet-Sequencing Data Of Peripheral Blood Mononuclear Cells, Natthaporn Kuendee, Denis Puthier, Catherine Nguyen, Kaj Chokeshaiusaha

The Thai Journal of Veterinary Medicine

Atopic dermatitis (AD) is a mutual allergic skin disease between humans and dogs manifesting varieties of similarities in their immune responses to the disease. Recently, activation-induced cell death (AICD) of NK cells was acknowledged as a novel disrupted immunoregulation in human AD. To gain insight into its plausible commotion in canine AD, NK cell expression profiles extracted from PBMC Drop-Sequencing (Drop-Seq) data of normal and AD dogs were analyzed along with human NK cell profiles of healthy and AD patients previously reported. According to the results, a total of 2,689 differentially expressed genes (DEG) between healthy and AD conditions (P≤0.0001) …

Subtyping Of Blastocystis Infection In Common Quails (Coturnix Coturnix) In Xinxiang City Of China, Xuehan Liu, Xuefeng Yang, Zhixing An, Yaming Ge, Rongjun Wang, Haiju Dong, Huili Zhu

The Thai Journal of Veterinary Medicine

Blastocystis is a unicellular anaerobic intestinal protist primarily of various animal species worldwide, and has been reported to inhabit humans as well. Blastocystis infections and subtype identification have been documented in China, although infections by the protist in quail remain unknown. Herein, a total of 128 fecal samples were collected from captive quails (Coturnix coturnix) in Xinxiang city, central China, and tested for the prevalence and genetic characteristics of Blastocystis. Ten (7.8%) samples were positive by PCR amplification and sequencing the barcode regeion of the SSU rRNA gene. Sequence analysis showed that ST7 was the predominant subtype with max identity …

Successful Management Of Feline Gastrointestinal Eosinophilic Sclerosing Fibroplasia With Mycophenolate Mofetil And Prednisolone Following Surgical Resection In A Cat, Min-Soo Kim, Keon Kim, Gwang-Hyun Lee, Cheol-Hyun Kim, Seo-Lin Jang, Guk-Hyun Suh, Chang-Min Lee

The Thai Journal of Veterinary Medicine

A 1-year-old castrated male Ragdoll who showed a series of vomiting and had reduced appetite presented to a local animal hospital. Hyperthermia and tachypnea were observed in physical examination, and leukocytosis was detected in hematological examination. Abdominal ultrasonography revealed an intramural mass with irregular echogenicity extending from the pylorus to the duodenum and loss of intestinal wall layer with regional lymph node enlargement. After exploratory laparotomy for biopsy and symptomatic alleviation, histopathological evaluation revealed densely infiltrated eosinophils within the branching and anastomosing trabecular pattern of collagen by several spindle-shaped cells. Finally, the patient was diagnosed with feline gastrointestinal eosinophilic sclerosing …

A Case Of Acquired Idiopathic Megaoesophagus In A Dog: The Use Of Sildenafil As Treatment, Yeremia Yobelanno Sitompul, Willy Moris Nainggolan, Bradley O’Hagan

The Thai Journal of Veterinary Medicine

Acquired idiopathic megaoesophagus in dogs is rarely found in Indonesia. In this case report, a dachshund dog was presented with a history of vomiting after eating. Clinical examination, complete blood count, kidney, and liver tests identified only minor dehydration. On observation of the dog after eating, the sign reported as vomiting was confirmed as regurgitation. Radiography and contrast studies identified a significantly dilated oesophagus. With an absence of other clinical abnormalities, the dog was diagnosed with idiopathic megaoesophagus and prescribed treatment with sildenafil twice daily at 0.75mg/kg for five days, along with postural management of feeding. Treatment resulted in cessation …