Medicine and Health Sciences Commons^™

St6galnac-I Promotes Lung Cancer Metastasis By Altering Muc5ac Sialylation, Imayavaramban Lakshmanan, Sanjib Chaudhary, Raghupathy Vengoji, Parthasarathy Seshacharyulu, Satyanarayana Rachagani, Joseph Carmicheal, Rahat Jahan, Pranita Atri, Ramakanth C. Venkata, Rohitesh Gupta, Saravanakumar Marimuthu, Naveenkumar Perumal, Sanchita Rauth, Sukhwinder Kaur, Kavita Mallya, Lynette M. Smith, Subodh M. Lele, Moorthy P. Ponnusamy, Mohd W. Nasser, Ravi Salgia, Surinder K. Batra, Apar Kishor Ganti

Journal Articles: Biochemistry & Molecular Biology

Lung cancer (LC) is the leading cause of cancer-related mortality. However, the molecular mechanisms associated with the development of metastasis is poorly understood. Understanding the biology of LC metastasis is critical to unveil the molecular mechanisms for designing targeted therapies. We developed two genetically engineered LC mouse models- Kras^G12D ;Trp53^R172H/+ ;Ad-Cre (KPA) and Kras^G12D ; Ad-Cre (KA). Survival analysis showed significantly (P=0.0049) shorter survival in KPA tumor-bearing mice as compared to KA, suggesting the aggressiveness of the model. Our transcriptomic data showed high expression of St6galnac-I in KPA compared to KA tumors. ST6GalNAc-I is an O-glycosyltransferase, which …

Serious Adverse Events And 30-Day Hospital Readmission Rate Following Elective Total Knee Arthroplasty: A Systematic Review And Meta-Analysis., Costas Papakostidis, Peter V Giannoudis, J. Tracy Watson, Robert Zura, R. Grant Steen

School of Medicine Faculty Publications

Background: Elective total knee arthroplasty (TKA) is a common surgery which has evolved rapidly. However, there are no recent large systematic reviews of serious adverse event (SAE) rate and 30-day readmission rate (30-dRR) or an indication of whether surgical methods have improved. Methods: To obtain a pooled estimate of SAE rate and 30-dRR following TKA, we searched Medline, Web of Science, Cochrane Library, and Google Scholar databases. Data were extracted by two authors following PRISMA guidelines. Eligibility criteria were defined prior to a comprehensive search. Studies were eligible if they were published in 2007 or later, described sequelae of TKA …

Commentary On "A Prospective, Single-Blinded, Bicentric Study, And Literature Review To Assess The Need Of C2-Ganglion Preservation - Saviour's Criteria"., James Harrop

Department of Orthopaedic Surgery Faculty Papers

No abstract provided.

A Secondary Analysis Of Peer Support And Family Acceptance Among Homosexual Living With Hiv And Antiretroviral Therapy: Quality Of Life Perspectives, Ina Martiana, Agung Waluyo, Sri Yona, Edianto Edianto

Jurnal Keperawatan Indonesia

Men who have sex with men (MSM) comprise a population at risk for HIV infection. Assessing the Quality of Life (QOL) in MSM might be different than other populations. This study showed a secondary analysis from our previous research. It was needed to understand whether peer support and family acceptance had an impact on QOL of MSM living with HIV and ART (Antiretroviral Therapy). A total of 175 respondents were involved in this cross-sectional study that was carried out with purposive sampling. The questionnaires were translated to Bahasa and tested for validity and reliability. Data questionnaires completed were analyzed. Results …

Improving Caregivers’ Perceived Involvement In Care Through Facilitating Communication With Hospital Providers, Heather Manolas

Student Scholarly Projects

Practice Problem: Involvement of family in care-planning for prevention of delirium in acute care settings is crucial, yet remains underutilized in those who are cognitively impaired. Despite the incidence of delirium in acute care worsening during COVID-19, many factors have led to it being placed on the back burner.

PICOT: In caregivers of cognitively impaired individuals, can implementation of an evidence-based, best practice tool that advocates for evidence-based delirium prevention strategies tailored to their loved-one and facilitates family involvement in care planning for these strategies during a healthcare experience as compared to no other intervention improve confidence in, and …

Pemberian Layanan Keluarga Berencana Berpengaruh Penting Terhadap Kejadian Unmet Need: Analisis Lanjut Data Sdki 2017, Helmi Safitri, Kemal N. Siregar, Tris Eryando, Rahmadewi Rahmadewi, Milla Herdayati, Dian Kristiani Irawaty

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Penelitian ini dilakukan untuk menilai sejauh mana pengaruh pemberian layanan KB terhadap unmet need pada wanita menikah usia 15-49 tahun. Unmet need merupakan fenomena dalam bidang kependudukan yang memerlukan penanganan serius dan segera karena dapat menghambat peningkatan CPR dan penurunan TFR. Pemberian layanan KB merupakan hal penting dalam memenuhi kebutuhan seseorang untuk memilih dan menggunakan alat KB yang tepat sesuai dengan kebutuhannya (tidak terjadi unmet need). Penelitian ini merupakan analisis lanjut data SDKI 2017, yang merupakan penelitian potong lintang pada wanita menikah usia 15-49 tahun. Jumlah sampel tersedia sebanyak 35.681 wanita. Analisis hubungan antara varaibel dependen dengan independen …

Factors Related To Doctors’ And Nurses’ Perceptions Of Evidence-Based Practice And Healthcare Information Access Through Information And Communications Technology, Melati Fajarini, Sri Rahayu, Ebaa M. Felemban, Agus Setiawan

Jurnal Keperawatan Indonesia

Evidence-based practice (EBP) that is supported by the availability of the best literature can improve the quality of health services. Information and communication technology (ICT) usage may provide the evidence in timely-manner. However, literature on the factors related to EBP and ICT of doctors and nurses in Indonesia is scant. This study aimed to describe the factors related to the doctors’ and nurses’ EBP perception and ICT. This survey was conducted in November 2017– January 2018 at one general hospital, five private hospitals, eleven public health centers, and five private clinics. A total of 85 doctors and 271 nurses selected …

Relationship Between Nurses’ Readiness And Institutional Readiness In Developing Nursing Career Paths In Public Health Centers, Tuti Afriani, Rr. Tutik Sri Hariyati, Dyah Fitri Wulandari

Jurnal Keperawatan Indonesia

Nursing career paths in public health centers have not been well established compared with nurses in hospitals. It is because the nursing career path has a different organizing system, which then becomes an obstacle in implementing the career path for nurses in primary health care. Therefore, this study aimed to identify the relationship between institutional and nurses’ readiness in implementing nursing career paths within public health centers. A cross-sectional study design with questionnaire as instrument was used in this research. A consecutive sampling technique was used to select 93 nurses from 13 public health centers. Furthermore, to identify the objective …

Patient Characteristics Related To Phlebitis In The East Coast Of Peninsular Malaysia Hospital, Azlina Daud, Fatimah Mohamad

Jurnal Keperawatan Indonesia

The insertion of peripheral intravenous catheters (PIVCs) is common for treatment among hospitalized patients. However, this procedure usually fails before the end of therapy because of several complications, including phlebitis. Therefore, this study aimed to determine the incidence and associated factors of phlebitis among patients with PIVC. A prospective cohort study was conducted in one of the hospitals located in East Coast Malaysia. The presence of phlebitis was assessed using the visual infusion phlebitis score checklist. The patients were followed until PIVC removal. A total of 321 data were collected among patients who received a new PIVC in the medical, …

Manfaat Penggunaan Mobile Health (M-Health) Dalam Pencatatan Dan Pelaporan Kesehatan Ibu, Ayu Diah Permatasari, Indang Trihandini, Ryza Jazid Bahar, Rico Kurniawan

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Kesehatan ibu masih menjadi masalah kesehatan prioritas. Salah satu upaya yang sudah dilakukan pemerintah adalah melakukan pencatatan dan pelaporan kesehatan ibu, yang diberi nama Pemantauan Wilayah Setempat Kesehatan Ibu dan Anak (PWS KIA). Namun, PWS KIA tersebut dinilai mengalami banyak kendala. Salah satu penyebabnya yaitu pelaksanaan PWS KIA yang masih menggunakan paper-based. Tujuan dari penelitian ini adalah untuk mengetahui manfaat penggunaan mHealth dalam pencatatan dan pelaporan kesehatan ibu. Metode yang digunakan adalah scoping review dari literatur yang diterbitkan lima tahun terakhir di pubmed dan google scholar yang membahas mengenai mHealth dalam pencatatan dan pelaporan kesehatan ibu. Hasil penelitian menunjukkan …

Systematic Literature Review: Pengaruh Negatif Stunting Terhadap Perkembangan Kognitif Anak, Aprilia Daracantika, Ainin Ainin, Besral Besral

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Satu dari tiga anak di Indonesia mengalami stunting. Stunting dapat berdampak terhadap perkembangan motorik dan verbal, peningkatan penyakit degeneratif, kejadian kesakitan dan kematian. Selain itu, keadaan stunting akan mengakibatkan pertumbuhan dan perkembangan sel-sel neuron terhambat sehingga mempengaruhi perkembangan kognitif pada anak. Dampak yang ditimbulkan oleh stunting terhadap perkembangan kognitif pada anak bervariasi, oleh karenanya penelitian ini bertujuan untuk mengetahui apa saja dampak stunting terhadap kemampuan kognitif pada anak. Metode yang digunakan adalah systematic literature review yang diambil dari jurnal nasional dan jurnal internasional. Penelusuran sumber pustaka dalam artikel ini melalui database Pubmed dan Google Scholar tahun 2010-2020.Berdasarkan hasil telaah didapatkan …

Cloning Of Pe11 (Lipx, Rv1169c) Gene Of Mycobacterium Tuberculosis Beijing Strain To Pcdna3.1 Plasmid Vector, Lulut Azmi Supardi, Andriansjah Rukmana, Fithriyah Sjatha

Makara Journal of Science

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. It is a persistent global health problem with a high mortality rate. Currently, TB is controlled by administering the Bacillus Calmette-Guerin (BCG) vaccine, but the effectiveness of its protection varies among individuals in a population. The pe/ppe gene family comprises a typical group of genes that play a role in avoiding the host immune response and inducing persistent TB infection. Based on in silico analysis, the pe11 gene has estimated immunogenicity and potential as a TB seed vaccine candidate. The pe11 gene from an Indonesian isolate of an M. …

Ion Channel Candidates Mediating Orexin Neuropeptide Actions On Brainstem Serotonergic Neurons, Saqlain Javed

NYMC Student Theses and Dissertations

A loss of neurons that synthesize the neuropeptide orexin produces the sleep disorder narcolepsy with cataplexy in humans and other animals. How symptoms of this disorder arise is not well understood, but selectively restoring orexin actions at 5-HT DR neurons rescues key symptoms (cataplexy), suggesting normal orexin signaling is important at these neurons. To better understand how orexin acts on these neurons, our lab identified a set of novel orexin actions that appear mediated by unidentified cation- permeable ion channels. To narrow down the list of possible channels, we used a bioinformatics approach to compare published gene expression profiles of …

Aspiring To “Make It Work”: Defining Resilience And Agency Amongst Hispanic Youth Living In Low-Income Neighborhoods, Sara Arias-Steele

USF Tampa Graduate Theses and Dissertations

This study explored how Hispanic youth (ages 13-21 years) living in low-income neighborhoods of Florida defined resiliency and expressed agency navigating personal challenges and neighborhood adversity in pursuit of success. From the standpoint of the participants, this study focused on how youths: 1) judge the quality of life in their neighborhoods and the opportunities available for them, 2) identify personal aspirations for themselves and 3) identify what resilient factors allowed them to face the challenges and barriers of their daily lives to pursue this aspiration. This study takes into account the structural barriers that create inequities to examine how personal …

Of Body And Mind: Bioarchaeological Analysis Of Nineteenth And Early Twentieth Century Anatomization And Institutionalization In Siena, Italy, Jacqueline M. Berger

USF Tampa Graduate Theses and Dissertations

Institutional bioarchaeology is a growing sub-field within bioarchaeology, particularly social bioarchaeology as informed by the biocultural approach. However, the majority of studies in this vein have primarily addressed English-speaking contexts, to include analyses of institutional assemblages preserved archaeologically, and anatomical collections. The present study examines of the Siena Craniological Collection (SCC) - located in Siena, Italy. The collection was assembled between 1862-1931, and originally contained remains of 1,122 patients from both the general and mental hospitals in operation in Siena during this period (Brasili-Gualandi & Gualdi-Russo, 1989a). In addition to demographic analysis of the Siena Craniological Collection as a whole, …

High Variation In Immune Responses And Parasite Phenotypes In Naturally Acquired Trypanosoma Cruzi Infection In A Captive Nonhuman Primate Breeding Colony In Texas, Usa, Angel M. Padilla, Phil Y. Yao, Tre J. Landry, Gretchen M. Cooley, Susan M. Mahaney, Isabela Ribeiro, John L. Vandeberg, Rick L. Tarleton

School of Medicine Publications

Trypanosoma cruzi, the causative agent of human Chagas disease, is endemic to the southern region of the United States where it routinely infects many host species. The indoor/outdoor housing configuration used in many non-human primate research and breeding facilities in the southern of the USA provides the opportunity for infection by T. cruzi and thus provides source material for in-depth investigation of host and parasite dynamics in a natural host species under highly controlled and restricted conditions. For cynomolgus macaques housed at such a facility, we used a combination of serial blood quantitative PCR (qPCR) and hemoculture to confirm infection …

Genetic Influences On Externalizing Psychopathology Overlap With Cognitive Functioning And Show Developmental Variation, Josephine Mollon, Emma E. M. Knowles, Samuel R. Mathias, Amanda Rodrigue, Tyler M. Moore, Monica E. Calkins, Ruben C. Gur, Juan M. Peralta, Daniel J. Weiner, John Blangero, Laura Almasy

School of Medicine Publications

Background: Questions remain regarding whether genetic influences on early life psychopathology overlap with cognition and show developmental variation.

Methods: Using data from 9,421 individuals aged 8-21 from the Philadelphia Neurodevelopmental Cohort, factors of psychopathology were generated using a bifactor model of item-level data from a psychiatric interview. Five orthogonal factors were generated: anxious-misery (mood and anxiety), externalizing (attention deficit hyperactivity and conduct disorder), fear (phobias), psychosis-spectrum, and a general factor. Genetic analyses were conducted on a subsample of 4,662 individuals of European American ancestry. A genetic relatedness matrix was used to estimate heritability of these factors, and genetic correlations with …

Relationships Between Internal Training Load In A Taper With Elite Weightlifting Performance Calculated Using Different Moving Average Methods, Joseph O. C. Coyne, Robert U. Newton, G. Gregory Haff

Research outputs 2014 to 2021

Purpose: A simple and 2 different exponentially weighted moving average methods were used to investigate the relationships between internal training load and elite weightlifting performance.

Methods: Training impulse data (sessional ratings of perceived exertion × training duration) were collected from 21 elite weightlifters (age = 26.0 [3.2] y, height = 162.2 [11.3] cm, body mass = 72.2 [23.8] kg, previous 12-mo personal best total 96.3% [2.7%] of world record total) during the 8 weeks prior to the 2016 Olympic Games qualifying competition. The amount of training modified or cancelled due to injury/illness was also collected. The training stress balance (TSB) …

Mothers’ Breastfeeding Practices And Self-Efficacy, Agrina Agrina, Febriana Sabrian, Oswati Hasanah, Erika Erika, Yesi Hasneli

Jurnal Keperawatan Indonesia

This study examined breastfeeding practices and self-efficacy among mothers residing in rural areas. A cross-sectional study was conducted for 104 mothers via purposeful sampling in a Posyandu (maternal and child health service) in Kampar district, one of the rural areas in Riau, Indonesia. The Breastfeeding Self-Efficacy Scale Short Form (BSES-SF) was used in the questionnaires to collect data. Chi-square test was used for bivariate analysis. Majority of the respondents (71.2%) were 20–35 years old; 69.3% of the respondents’ level of education were low (such as junior and senior high school levels). Approximately 91.3% of them were housewives. Exclusive breastfeeding prevalence …

Phenomenological Study On The Experience Of Male Nurses In Caring For Female Patients, Anik Maryunani, Rr. Tutik Sri Hariyati, Enie Novieastari

Jurnal Keperawatan Indonesia

Nurses provide care equally and do not discriminate between men and women. However, male nurses face challenges and obstacles, especially when they take care of female patients. This study aimed to explore the experiences of male nurses who look after female patients by using a descriptive qualitative design with a phenomenological approach. Ten male nurse participants aged 26–43 years and having an experience of caring for female patients for at least 2 years were included in this study. Seven themes were identified: the discomfort of female patients and male nurses; patient’s trust and privacy; the identification of factors affected by …

Effect Of Ketamine On Cardiovascular Function During Procedural Sedation Of Adults, Kara Goddard, Christopher Sampson, Starr-Mar'ee Bedy, Rugheed Ghadban, Julie Stilley

2020-Current year OA Pubs

INTRODUCTION: Ketamine is commonly used in emergency department procedural sedation. Mild to moderate transient increases in blood pressure, heart rate, and cardiac output are common due to ketamine causing an increase in sympathetic activity. There is a concern that these physiological changes could result in an increased myocardial oxygen demand that may exacerbate underlying cardiac disease.

METHODS: Convenience sample of patients older than 50 years receiving ketamine for procedural sedation in the emergency department was used (n = 31). Patients were selected to receive ketamine based on provider discretion. Primary outcome was incidence of new myocardial ischemia apparent on an …

Determining The Effects Of Exogenous Human Chorionic Gonadotropin And Pregnant Mare Serum Gonadotropin On Plasma Testosterone, Testicular Volume, And Semen Production In Leopard Geckos (Eublepharis Macularius), Alexandra Mason

LSU Master's Theses

Planet earth has now entered into its sixth mass extinction as a result of expanding human populations, posing an unprecedented threat to biologic diversity. Climate change, habitat fragmentation, wildlife trade, pollution, and biological invasions are just a few consequences of human activities that have directly contributed to unprecedented species extinctions. While widespread amphibian declines have gained more recent attention, it has been proposed that reptiles may be in even greater danger of extinction worldwide. Unfortunately, many reptiles are destined to go extinct before many of their basic biologic traits, including reproductive methods, have even been determined.

In order to mitigate …

Covid-19 And Campus Life: Student Perspectives, Ryan Shah

Osmosis Magazine

The COVID-19 pandemic has caused unprecedented changes to campus life as students have adjusted to the hybrid class model and physical distancing framework. Simply residing on campus this semester has been a privilege; many Spiders, especially international students and students with pre-existing health conditions, could not come at all. Among students on campus, there are varying attitudes about how this semester of “Protecting Our Web” has gone. To document this historic semester, I interviewed three students in mid- October:

• Colin Sparkevicius, a senior from Pennsylvania majoring in business administration
• Tereza Hernandez, a sophomore from Virginia majoring in global studies
• Karthik …

“A Fitbit For Your Brain”-Elon Musk, Sci-Fi Or Attainable?, Ryan Cvelbar

Osmosis Magazine

Just a couple months ago, Elon Musk, the CEO of Tesla, SpaceX, and now Neuralink, debuted his enhanced design of the Neuralink, a wireless brain implant the size of a coin, which he plans to use to ultimately facilitate the achievement of a state of symbiosis between humans and artificial intelligence. Specifically, Musk envisions a world where we can control technology with our minds by connecting the neurons of our brains to the Neuralink and hence, digitally to computers.

We’Ve Got Your Back: New Studies In Spinal Cord Regeneration, Joshua Pandian

Osmosis Magazine

Every day, the spinal cord transmits messages between the brain and body at speeds of 270 miles per hour. The spinal cord allows us to walk, run, or swim. However, for 200,000 Americans who suffer from spinal cord injury (SCI), simply standing up is often not a possibility. This number rises by approximately 17,000 cases a year as a result of sports injuries, car accidents, motorcycle collisions, or falls. Unlike many cells in the body, the neurons in the spinal cord cannot regenerate after an injury, which means spinal cord injuries tend to last for the remainder of one’s lifetime.

Salmonella: Clever Bacteria, Najnin Rimi

Osmosis Magazine

A recent outbreak of salmonella caused many grocery stores to recall their onions and many unknowing consumers to become ill. A major produce supplier from California, Thompson International Inc., had announced a recall on August 1st for all onion types distributed by the company starting May 1st of 2020. This caused a recall from over hundreds of grocery stores, even our familiar Kroger and Walmart grocery stores.

Passive Antibody Therapy: Potentially The First Covid-19 Treatment, Caterina Erdas

Osmosis Magazine

While the world anxiously waits for a COVID-19 vaccine, thousands of people are in critical condition, in need of help today. Scientists are wondering what tools they have now to prevent the spread of COVID-19 and help save the lives of patients in critical condition. Passive antibody therapy may be the solution.

Illuminating Health Disparities: The Untold Story Of Black Women’S Pregnancies, Kacy Workman

Osmosis Magazine

Recent studies have found that Black women are 3-4 times more likely to die from pregnancy-related complications than White women. Researchers in the 1990s examined data surrounding specific pregnancy complications such as postpartum hemorrhage, finding that although prevalence rates were similar between White and Black women, Black women with these conditions were 2-3 times more likely to die than their White counterparts. Despite medical advances, these rates have not improved over time. Data analyses examining maternal mortality from 2005 – 2014 reveal that mortality rates for Black women have actually increased from 39 to 49 deaths for every 100,000 live …

Ai And Art: An Increasingly Inextricable Affair, Rebecca Hedlund

Osmosis Magazine

Siri, Waze, Google Translate, Instagram -- we experience Artificial Narrow Intelligence (ANI) every day of our lives when we use apps that are trained for a specific task, such as when Spotify recommends new songs based on the music you already like. These apps compute the data users give (whether knowingly or not) and adjust their own algorithms to provide the best possible experience. This is an application of Artificial Intelligence called machine learning. While some see it as a subset of AI, many argue that the ability to learn and improve through experience is critical to the very definition …

The Benefits Of Reading On Longevity, Olivia Lomax

Osmosis Magazine

What if I told you there is a scientifically proven way of adding time to your life that is as simple as reading a few chapters of your favorite book? A study performed at Yale University School of Public Health compared the longevity of people who read books to those who only read periodicals. Those conducting the study predicted that the book-readers would have increased levels of survival, as reading books has been shown to promote two distinct cognitive properties tied to longevity.