Medicine and Health Sciences Commons^™

Mental Health Issues In First Responders: Their Causes And How To Help Treat Them, Anna M. Hoffnagle

English Department: Research for Change - Wicked Problems in Our World

In recent years mental health issues and how to deal with them has become a widely discussed topic in society. Causes and treatments tend to be major factors in the discussion, but they also tend to be far too general. The broadness of the targeted audience for these discussions often creates more issues than it solves due to treatments not being effective for every population. This paper highlights the causes of mental health issues in first responders while also discussing treatment methods designed specifically for this population that have had promising outcomes. Causes and treatments discussed are given solidity through …

Mental Health Affects Of The Covid-19 Pandemic, Mia Kepler

English Department: Research for Change - Wicked Problems in Our World

Over the past year worldwide everyone has experienced the Covid-19 pandemic in one way or another. As time evolves during the pandemic mental health is getting worse every day. People are experiencing feelings of loneliness and uneasiness. Mental health professionals are trying to find solutions to this major issue in today's society. Change is needed to prevent people's mental health from worsening during these unprecedented times and to help the people who are already suffering.

The Opioid Crisis Meets Covid-19 Pandemic, Hannah M. Westerman

English Department: Research for Change - Wicked Problems in Our World

Abstract: How have the COVID-19 pandemic and the Opioid Crisis have collided to create a negative effect on those who abuse drugs and other substances? These two wicked problems are now collectively making it more difficult for those to recover and overcome substance and drug abuse worsening the Opioid Epidemic. With no clear answer in sight can vaccines and more accessible rehab help to progress these wicked problems?

Corruption In Capsules: How It Is Legal For Companies To Put Harmful Ingredients In Vitamins And Dietary Supplements, Emily Leggiero

English Department: Research for Change - Wicked Problems in Our World

The vitamin and supplement industry has increased exponentially in profits as well as potential products on the market since the turn of the century. However, these products are not regulated, nor do they undergo any premarket clinical research or testing. Public health is compromised by vitamins and supplements that are available for American consumption that is disproportionately unregulated to their chemically similar counterparts. This wicked problem is facilitated through the combination of historical legislative definitions that has since been distorted for corrupt administrative gain through the allotment of corporate expenditures. Company disbursements are made to the same policymakers that create …

Obesity: A Growing Concern In America, Julie T. Garrity

English Department: Research for Change - Wicked Problems in Our World

No abstract provided.

Drug Addiction & Mental Health, Tyler Burkholder

English Department: Research for Change - Wicked Problems in Our World

Drugs have a serious effect on our mental health, and mental health has a major effect on drug abuse and addiction. There is a reason so many drug users usually need to keep going back to rehab. It is because drugs affect mental health to a point where you aren’t the same person during and even after drug addiction. Poor mental health also can be a major cause influencing people to start doing drugs. People with depression, anxiety disorders, mood disorders are more prone to drug use. That is why we need to make it a public policy to screen …

Save The Rich, Connor Harris

English Department: Research for Change - Wicked Problems in Our World

The problem of medication pricing and lobbying in the healthcare industry has caused millions of people within the United States to not be able to afford medications essential to their lives. Pharmaceutical companies are taking advantage of the need people have for certain drugs by setting the sale price far higher than it costs to produce. My suggested solution is to make lobbying illegal in the United States so that pharmaceutical companies would not have control over government officials who pass laws to help or hurt the issue of medication pricing. Illegalizing government lobbying will take away the incentive politicians …

The Struggle Of Mental Health Within College Students, Skyler R. West

English Department: Research for Change - Wicked Problems in Our World

One in five college students have thoughts of committing suicide daily. We often wonder what may lead to thoughts like this. This essay uses a subjective approach to broaden the knowledge of readers regarding mental health problems within college students. In this essay, readers discover the statistical findings of factors like alcohol, nicotine, schoolwork and athletics factoring into a student's psychological destressed mental state. Without having available and anonymous resources accessible to them, students are not able to get the help they need.

Mental Health In Music: Why Are We Not Talking About It?, Christian Pence

English Department: Research for Change - Wicked Problems in Our World

The music business has taken many hits over the past 20 years, and we are seeing musicians slowly going extinct. There are so many factors that are hurting musicians, and workers in the music business. Back in the 80’s and 90’s, we were investing in music like no tomorrow. So many concerts were happening, and so many Broadway shows were going on. We were really supporting our musicians, and we were helping them in any way we could. But society, has not been investing in musicians, causing certain problems, like financial stability, mental health problems, and making music more of …

Physician Burnout: Stress Within The Health Care System, Aidan Hauser

English Department: Research for Change - Wicked Problems in Our World

As our nation’s healthcare system expands, more stress and responsibility are placed on our physicians and frontline healthcare workers. The pressures of the daily job often prove extremely damaging to the employee’s mental and physical health. Physician and worker burnout is a growing epidemic that is damaging our care providers more and more every day. Burnout effects not only workers, but all of those surrounding them as well. This plague is not going to be repaired by one single change, but it is clear that many adjustments must be made to reform our healthcare system.

Mental Health And Covid-19, Haley Thiel

English Department: Research for Change - Wicked Problems in Our World

The recent pandemic has taken a toll on everyone’s mental health. Transitioning to full freedom and opportunity to lockdown with no human interaction was a huge adjustment. The global pandemic especially hit home to college students and had a significant impact on universities. In this paper we discuss and analyze how the pandemic has shifted college students mental health and the negative toll it had. We will examine how anxiety, depression, and other general mental health disorders have skyrocketed in college students during the pandemic. The need for reform and attention on college campuses to preserve students mental health is …

Effect Of Arm Eccentric Exercise On Muscle Damage Of The Knee Flexors After High-Intensity Eccentric Exercise, Xin Ye, William M. Miller, Sunggun Jeon, Jun Seob Song, Tyler J. West

Faculty and Student Publications

Repeated bout effect (RBE) describes a phenomenon that an initial unaccustomed eccentric exercise (ECC) bout can confer a protective effect against muscle damage from the subsequent same exercise. This protection has been observed in the same muscle, as well as the contralateral homologous (CL-RBE) muscle. But it is unknown whether the RBE is evident for non-local unrelated heterogonous muscles. The purpose of this study was to examine whether an initial elbow flexion (EF) muscle-damaging ECC could confer RBE against muscle damage from the subsequent ECC performed in the remote lower limb knee flexor (KF) muscle group. Twenty-seven young individuals were …

2021-04-08_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Monday - Saturday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …

Closing The Gap: A Course Design To Prevent Social Media Mishaps In The Clinical Setting, Stacy Gabbard

Morehead State Theses and Dissertations

A capstone submitted in partial fulfillment of the requirements for the degree of Doctor of Education in the Ernst and Sara Lane Volgenau College of Education at Morehead State University by Stacy Gabbard on April 8, 2021

2021-04-08_Michiganoverview_Covidoutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_102057---,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

COVID-19 outbreaks are generally defined as two or more cases with a link by place and time indicating a shared exposure outside of a household. Local health departments report the number of new and ongoing outbreaks they are investigating by the setting of the outbreak. New outbreaks are those outbreaks that were first identified during the current reporting week. Ongoing outbreaks are …

Keratinocyte-Derived Microvesicle Particles Mediate Ultraviolet B Radiation-Induced Systemic Immunosuppression, Langni Liu, Azeezat A. Awoyemi, Katherine E. Fahy, Pariksha Thapa, Christina E. Borchers, Benita Y. Wu, Cameron L. Mcglone, Benjamin Schmeusser, Zafer Sattouf, Craig A. Rohan, Amy R. Williams, Elizabeth E. Cates, Christina Kinsely, Lisa E. Kelly, Ji C. Bihl, David R. Cool, Ravi P. Sahu, Jinju Wang, Yanfang Chen, Christine M. Rapp, Michael G. Kemp, Ron Michael Johnson, Jeffrey B. Travers

Dermatology Faculty Publications

A complete carcinogen, ultraviolet B (UVB) radiation (290–320 nm), is the major cause of skin cancer. UVB-induced systemic immunosuppression that contributes to photocarcinogenesis is due to the glycerophosphocholine-derived lipid mediator platelet-activating factor (PAF). A major question in photobiology is how UVB radiation, which only absorbs appreciably in the epidermal layers of skin, can generate systemic effects. UVB exposure and PAF receptor (PAFR) activation in keratinocytes induce the release of large numbers of microvesicle particles (MVPs; extracellular vesicles ranging from 100 to 1000 nm in size). MVPs released from skin keratinocytes in vitro in response to UVB (UVB-MVPs) are dependent on …

Pld3 Is A Neuronal Lysosomal Phospholipase D Associated With Β-Amyloid Plaques And Cognitive Function In Alzheimer's Disease., Alex G Nackenoff, Timothy J Hohman, Sarah M Neuner, Carolyn S Akers, Nicole C Weitzel, Alena Shostak, Shawn M Ferguson, Bret Mobley, David A Bennett, Julie A Schneider, Angela L Jefferson, Catherine C Kaczorowski, Matthew S Schrag

Faculty Research 2021

Phospholipase D3 (PLD3) is a protein of unclear function that structurally resembles other members of the phospholipase D superfamily. A coding variant in this gene confers increased risk for the development of Alzheimer's disease (AD), although the magnitude of this effect has been controversial. Because of the potential significance of this obscure protein, we undertook a study to observe its distribution in normal human brain and AD-affected brain, determine whether PLD3 is relevant to memory and cognition in sporadic AD, and to evaluate its molecular function. In human neuropathological samples, PLD3 was primarily found within neurons and colocalized with lysosome …

Exploring Animal Assisted Therapy As A Therapeutic Tool For Use In Occupational Therapy, Malia Proveaux

MOT Student Capstones

Occupational therapy (OT) is an evidence-based and effective therapeutic approach; however, patient compliance and participation are the most significant factors determining outcome measures. Animal Assisted Therapy (AA T) is a therapeutic approach used for various disorders and medical diagnoses and has been showing strong growth in recent years. Animal-assisted therapy is the interaction of a patient and a trained animal to aid the patients' progress toward their functional goals and is a valuable complement to OT. The purpose of this study is to examine the evidence-based research supporting the inclusion of AAT during skilled OT interventions to improve clinical impact. …

Establishing Ot Programming Within A Local Correctional Facility, Kayla Kennedy

OTD Capstone Projects

This OTD capstone project was completed in collaboration with Davidson County Sheriff's Office in Nashville, TN. The criminal justice system is an emerging practice area for occupational therapy with limited established OT programs in jails and prisons. Individuals who are incarcerated have limited social interaction promoting positive behaviors, limited access to quality rehabilitative services, are separated from family/friends, may be placed in isolation and overall experience occupational deprivation. This capstone project aimed to establish OT programming in a local correctional facility using the Recovery Model and MOHO to address needs of residents of the Behavioral Care Center in a long-term …

2021-04-08_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Effects Of News And Threat Perceptions On Americans’ Covid-19 Precautionary Behaviors, Riva Tukachinsky Forster, Megan A. Vendemia

Communication Faculty Articles and Research

Our study examines the relationship between news exposure at the onset of the COVID-19 pandemic, personal threat beliefs, beliefs about others’ threat perceptions, and participation in precautionary actions. A survey of 377 U.S . adults revealed a significant main effect of news exposure on various precautionary behaviors (e.g., facial mask wear, physical distancing). Personal threat beliefs and beliefs about others’ threat perceptions serve as unique mechanisms mediating the effect of news on specific CDC-recommended and less socially desirable actions. These findings can guide news sources covering health crises in a socially responsible manner.

Role Of Ampk And Akt In Triple Negative Breast Cancer Lung Colonization, Jeremy Johnson, Zeta Chow, Eun Young Lee, Heidi L. Weiss, B. Mark Evers, Piotr G. Rychahou

Pathology and Laboratory Medicine Faculty Publications

Triple negative breast cancer (TNBC) is an aggressive disease with a 5-y relative survival rate of 11% after distant metastasis. To survive the metastatic cascade, tumor cells remodel their signaling pathways by regulating energy production and upregulating survival pathways. AMP-activated protein kinase (AMPK) and Akt regulate energy homeostasis and survival, however, the individual or synergistic role of AMPK and Akt isoforms during lung colonization by TNBC cells is unknown. The purpose of this study was to establish whether targeting Akt, AMPKα or both Akt and AMPKα isoforms in circulating cancer cells can suppress TNBC lung colonization. Transient silencing of Akt1 …

Associations Among Stress, Anxiety, Depression, And Emotional Intelligence Among Veterinary Medicine Students, Julia Wells, Kylie Watson, Robert E. Davis, Syed Siraj A. Quadri, Joshua R. Mann, Ashutosh Verma, Manoj Sharma, Vinayak K. Nahar

Environmental & Global Health Faculty Research

Background: Veterinary students are faced with immense pressures and rigors during school. These pressures have contributed to elevated levels of stress, anxiety, and depression (SAD) among veterinary students relative to the general population. One proposed concept to help students combat SAD is that of emotional intelligence (EI). We explored the relationship between EI and SAD among veterinary students at a college in the Southeast United States. Methods: A crosssectional study design was implemented among a convenience sample of 182 veterinary medical students. The survey instrument contained 56 items that elicited information about students’ demographics, perceived stress, anxiety, and depression, and …

Influence Of Previous Covid-19 And Mastitis Infections On The Secretion Of Brain-Derived Neurotrophic Factor And Nerve Growth Factor In Human Milk, Veronique Demers-Mathieu, Dustin J. Hines, Rochelle M. Hines, Sirima Lavangnananda, Shawn Fels, Elena Medo

Psychology Faculty Research

Background: Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) play a critical role in neurodevelopment, where breast milk is a significant dietary source. The impact of previous COVID-19 infection and mastitis on the concentration of BDNF and NGF in human milk was investigated. Methods: Concentrations of BDNF and NGF were measured via ELISA in human milk samples collected from 12 mothers with a confirmed COVID-19 PCR, 13 mothers with viral symptoms suggestive of COVID-19, and 22 unexposed mothers (pre-pandemic Ctl-2018). These neurotrophins were also determined in 12 mothers with previous mastitis and 18 mothers without mastitis. Results: The NGF …

Covid-19 And Preparing Planetary Health For Future Ecological Crises: Hopes From Glycomics For Vaccine Innovation, Xueqing Wang, Zhaohua Zhong, Wei Wang

Research outputs 2014 to 2021

A key lesson emerging from COVID-19 is that pandemic proofing planetary health against future ecological crises calls for systems science and preventive medicine innovations. With greater proximity of the human and animal natural habitats in the 21st century, it is also noteworthy that zoonotic infections such as COVID-19 that jump from animals to humans are increasingly plausible in the coming decades. In this context, glycomics technologies and the third alphabet of life, the sugar code, offer veritable prospects to move omics systems science from discovery to diverse applications of relevance to global public health and preventive medicine. In this expert …

A Rapidly Aging World In The 21st Century: Hopes From Glycomics And Unraveling The Biomarkers Of Aging With The Sugar Code, Xinwei Yu, Wei Wang

Research outputs 2014 to 2021

A global rise in life expectancy comes with an increased burden of serious life-long health issues and the need for useful real-time measures of the aging processes. Studies have shown the value of biochemical signatures of immunoglobulin G (IgG) N-glycosylation as clinically relevant biomarkers to differentiate healthy from accelerated aging. Most human biological processes rely on glycosylation of proteins to regulate their function, but these events appear sensitive to environmental changes, age, and the presence of disease. Specifically, variations in N-glycosylation of IgG can adversely affect inflammatory pathways underpinning unhealthy aging and chronic disease pathogenesis. This expert review highlights the …

Suicide Assessment, Angelo Rannazzisi, Psyd

Department of Family & Community Medicine Presentations and Grand Rounds

Agenda

● Risk & Protective Factors of Suicide

• Demographic, Diagnostic, Psychological Variables

● Suicide Risk Assessment

• C-SSRS (Columbia-Suicide Severity Rating Scale)
• BDI-II (Beck Depression Inventory 2nd Edition)
• Reasons for Living Inventory (RFL)

● Creating a Safety Plan

Sirt3 Is Required For Liver Regeneration But Not For The Beneficial Effect Of Nicotinamide Riboside, Sarmistha Mukherjee, James Mo, Lauren M Paolella, Caroline E Perry, Jade Toth, Mindy M Hugo, Qingwei Chu, Qiang Tong, Karthikeyani Chellappa, Joseph A Baur

Children’s Nutrition Research Center Staff Publications

Liver regeneration is critical to survival after traumatic injuries, exposure to hepatotoxins, or surgical interventions, yet the underlying signaling and metabolic pathways remain unclear. In this study, we show that hepatocyte-specific loss of the mitochondrial deacetylase SIRT3 drastically impairs regeneration and worsens mitochondrial function after partial hepatectomy. Sirtuins, including SIRT3, require NAD as a cosubstrate. We previously showed that the NAD precursor nicotinamide riboside (NR) promotes liver regeneration, but whether this involves sirtuins has not been tested. Here, we show that despite their NAD dependence and critical roles in regeneration, neither SIRT3 nor its nuclear counterpart SIRT1 is required for …

Propranolol For Treatment Of Infantile Hemangioma: Efficacy And Effect On Pediatric Growth And Development, Rachel A. Giese, Merit Turner, Mario Cleves, J. Reed Gardner, Gresham T. Richter

School of Medicine Publications

Purpose. Propranolol has been successful in treating problematic infantile hemangiomas (IH) but concerns regarding its effect on normal growth and development have been raised. This study examines physical growth, developmental milestones, and human growth hormone (hGH) levels in infants receiving propranolol for problematic IH.

Method. Monthly heights and weights of children undergoing propranolol therapy for IH were prospectively collected and tabulated. Data analysis and comparison to World Health Organization (WHO) weight-for-age and weight-to-length z-scores was performed. Questionnaires regarding milestones, efficacy, and guardian satisfaction were performed, and a combination of both chart results and phone conducted surveys was tabulated. Serum …

Analysis Of An Obstetrics Point-Of-Care Ultrasound Training Program For Healthcare Practitioners In Zanzibar, Tanzania., Elizabeth A Hall, Danielle Matilsky, Rachel Zang, Naomasa Hase, Ali Habibu Ali, Patricia C Henwood, Anthony J Dean

Department of Emergency Medicine Faculty Papers

BACKGROUND: A point-of-care ultrasound education program in obstetrics was developed to train antenatal healthcare practitioners in rural Zanzibar. The study group consisted of 13 practitioners with different training backgrounds: physicians, clinical officers, and nurse/midwives. Trainees received an intensive 2-week antenatal ultrasound course consisting of lectures and hands-on practice followed by 6 months of direct supervision of hands-on scanning and bedside education in their clinical practice environments. Trainees were given a pre-course written exam, a final exam at course completion, and practical exams at 19 and 27 weeks. Trainees were expected to complete written documentation and record ultrasound images of at …